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Pre-emptive deceased-donor kidney transplant: A matched cohort study
Una aproximación al trasplante renal anticipado de donantecadáver. Estudio de cohortes emparejadas
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Estudio de cohortes emparejadas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "32" "paginaFinal" => "37" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pre-emptive deceased-donor kidney transplant: A matched cohort study" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 797 "Ancho" => 1461 "Tamanyo" => 70153 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Supervivencia del receptor de trasplante renal en los grupos prediálisis y control (<span class="elsevierStyleItalic">log-rank</span>; p = 0,730).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Franco, Patricio Más-Serrano, Yussel González, Noelia Balibrea, David Rodríguez, María Isabel López, Francisco Javier Pérez Contreras" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Franco" ] 1 => array:2 [ "nombre" => "Patricio" "apellidos" => "Más-Serrano" ] 2 => array:2 [ "nombre" => "Yussel" "apellidos" => "González" ] 3 => array:2 [ "nombre" => "Noelia" "apellidos" => "Balibrea" ] 4 => array:2 [ "nombre" => "David" "apellidos" => "Rodríguez" ] 5 => array:2 [ "nombre" => "María Isabel" "apellidos" => "López" ] 6 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Pérez Contreras" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2013251420300122" "doi" => "10.1016/j.nefroe.2019.04.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420300122?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301201?idApp=UINPBA000064" "url" => "/02116995/0000004000000001/v1_202001221359/S0211699519301201/v1_202001221359/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2013251420300092" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2019.02.009" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "624" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2020;40:38-45" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Detrimental effect of renin-angiotensin blockade on progression of chronic kidney disease at later stages: A matter of dosage adjustment?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "38" "paginaFinal" => "45" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto negativo del bloqueo del sistema renina-angiotensina sobre la progresión de la enfermedad renal crónica avanzada: ¿una cuestión de ajuste de dosis?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1336 "Ancho" => 1667 "Tamanyo" => 152825 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Linear regression between the slope of the glomerular filtration rate (GFR)/time and proteinuria. The regression lines shown in the figure correspond to each subgroup, with double blockade and monotherapy, respectively. The Y axis is represented with an exponential scale 0.5.</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The combined linear regression equation is: Slope GFR/time (ml/min/1.73 m<span class="elsevierStyleSup">2</span>/year) = −1.720 – (0.739 × proteinuria in g/g creatinine); R = 0.332; p < 0.0001.</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">For monotherapy patients: Slope FG/time = −1532 – (0.727 × proteinuria in g/g creatinine); R = 0.315; p < 0.0001.</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">For patients with double blockade: Slope FG/time = −4409 – (0.495 × proteinuria in g/g creatinine); R = 0.275; p < 0.011.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Caravaca-Fontán, Julián Valladares, Rosa Díaz-Campillejo, Sergio Barroso, Enrique Luna, Francisco Caravaca" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Caravaca-Fontán" ] 1 => array:2 [ "nombre" => "Julián" "apellidos" => "Valladares" ] 2 => array:2 [ "nombre" => "Rosa" "apellidos" => "Díaz-Campillejo" ] 3 => array:2 [ "nombre" => "Sergio" "apellidos" => "Barroso" ] 4 => array:2 [ "nombre" => "Enrique" "apellidos" => "Luna" ] 5 => array:2 [ "nombre" => "Francisco" "apellidos" => "Caravaca" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699519300943" "doi" => "10.1016/j.nefro.2019.02.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519300943?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420300092?idApp=UINPBA000064" "url" => "/20132514/0000004000000001/v1_202003180708/S2013251420300092/v1_202003180708/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2013251420300237" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2019.06.005" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "642" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Nefrologia (English Version). 2020;40:26-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware!" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "26" "paginaFinal" => "31" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad renal asociada con esteroides anabólicos androgénicos y abuso de suplementos vitamínicos: ¡tenga cuidado!" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1353 "Ancho" => 2495 "Tamanyo" => 331463 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pathophysiology of kidney injury due to AAS use. AAS, anabolic androgenic steroids. Question marks indicate mechanisms that are not understood. AQP, aquaporin. PCT, proximal convoluted tubule. CD, collecting duct. MAP, mean arterial pressure. FSGS, focal segmental glomerulosclerosis. TNF-α, tumor necrosis factor α. ATN, acute tubular necrosis. AIN, acute interstitial nephritis. CIN, chronic interstitial nephritis. GN, glomerulonephropathy. uKIM-1, urinary kidney injury molecule 1. uMCP-1, urinary monocyte chemoattractant protein 1. uNGAL, urinary neutrophil gelatinase-associated lipocalin. uALP, urinary alkaline phosphatase. uγ-GT, urinary γ-glutamil transpeptidase. CKD, chronic kidney disease. AKI, acute kidney injury.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sérgio Luiz Arruda Parente Filho, Pedro Eduardo Andrade de Carvalho Gomes, Guilherme Aguiar Forte, Laio Ladislau Lopes Lima, Geraldo Bezerra da Silva Júnior, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins, Elizabeth De Francesco Daher" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Sérgio Luiz Arruda" "apellidos" => "Parente Filho" ] 1 => array:2 [ "nombre" => "Pedro Eduardo Andrade de Carvalho" "apellidos" => "Gomes" ] 2 => array:2 [ "nombre" => "Guilherme Aguiar" "apellidos" => "Forte" ] 3 => array:2 [ "nombre" => "Laio Ladislau Lopes" "apellidos" => "Lima" ] 4 => array:2 [ "nombre" => "Geraldo Bezerra da" "apellidos" => "Silva Júnior" ] 5 => array:2 [ "nombre" => "Gdayllon Cavalcante" "apellidos" => "Meneses" ] 6 => array:2 [ "nombre" => "Alice Maria Costa" "apellidos" => "Martins" ] 7 => array:2 [ "nombre" => "Elizabeth De Francesco" "apellidos" => "Daher" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0211699519301419" "doi" => "10.1016/j.nefro.2019.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699519301419?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251420300237?idApp=UINPBA000064" "url" => "/20132514/0000004000000001/v1_202003180708/S2013251420300237/v1_202003180708/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Pre-emptive deceased-donor kidney transplant: A matched cohort study" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "32" "paginaFinal" => "37" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antonio Franco, Patricio Más-Serrano, Yussel González, Noelia Balibrea, David Rodríguez, María Isabel López, Francisco Javier Pérez Contreras" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Antonio" "apellidos" => "Franco" "email" => array:1 [ 0 => "franco_ant@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Patricio" "apellidos" => "Más-Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Yussel" "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Noelia" "apellidos" => "Balibrea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "David" "apellidos" => "Rodríguez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "María Isabel" "apellidos" => "López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Francisco Javier Pérez" "apellidos" => "Contreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital General Universitario de Alicante, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Farmacia Hospitalaria, Hospital General Universitario de Alicante, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Una aproximación al trasplante renal anticipado de donantecadáver. Estudio de cohortes emparejadas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 743 "Ancho" => 1443 "Tamanyo" => 68072 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Kidney transplant graft survival in the pre-dialysis and control groups (<span class="elsevierStyleItalic">log-rank</span>; p = 0.693).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic kidney disease (CKD) causes significant morbidity and mortality, especially cardiovascular.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its severity is divided into stages from least to most severe<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>; stage 5 is the situation in which it becomes necessary to adopt a series of strategies of treatment including the initiating of renal replacement therapy which will not only keep the patients alive, but also, at least in part, will maintain quality of life.</p><p id="par0010" class="elsevierStylePara elsevierViewall">As a general rule, patients are initially included in a dialysis program, either haemodialysis or peritoneal dialysis.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Both treatments are effective to maintain the patient alive; it requires prior surgical procedures, either the placement of an arteriovenous fistula or insertion of a central venous or peritoneal catheter.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> Moreover, these replacement treatments are far from effectively compensating for all of the lost kidney functions, therefore we only achieve partial treated hoping, if there are no contraindications, to apply definitive complete treatment.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">At this time, we have one effective and complete treatment for CKD. Kidney transplant is the treatment of choice in most patients with end-stage CKD.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> Achieving adequate graft survival requires administering chronic pharmacological immunosuppression, but this also promotes the occurrence of opportunistic infections<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and the incidence of cancer increases.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a> Nevertheless, it manages to restore the patient's previous health condition, since the transplanted kidney fully replaces the functions lost by the native kidney, therefore the benefit/risk ratio is positive.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Generally, deceased-donor kidney transplantation is considered when the patient is already on renal replacement therapy. Dialysis is generally a necessary, but not obligatory, step before kidney transplantation in patients who are candidates for this procedure. It is possible to have a kidney transplant without prior dialysis, this is known as a pre-emptive, or pre-dialysis kidney transplant: a reality in recipients from living donors,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> although it remains conditional in the case of deceased donors due to the scarcity of organs.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8,13</span></a> In France, pre-emptive deceased-donor kidney transplants have been incentivized in recent years, with an increase from 5.6% to 15.5% between 2007 and 2014, with good outcomes.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In 2007, our centre started a pre-emptive deceased-donor kidney transplant programme. It should be noted that patients in a pre-dialysis situation only receive a transplant if there is no candidate for transplant in patient on renal replacement therapy.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The objective of this study is to evaluate the results of our experience in pre-emptive, deceased-donor kidney transplantation via a retrospective observational study with matched cohorts.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">The design of the study was retrospective, observational study with matched cohorts.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Recipients who received a kidney transplant from a brain dead donor at the Hospital General Universitario de Alicante [Alicante General University Hospital] between 2007 and 2016 were included. Two groups were defined: a pre-dialysis group (pre-dialysis patients who received a pre-emptive, deceased-donor transplant) and a control group (patients in renal replacement therapy who received a first transplant from a deceased donor).</p><p id="par0045" class="elsevierStylePara elsevierViewall">Inclusion criteria: All patients in a pre-dialysis situation (pre-dialysis group) who received a kidney transplant between 2007 and 2016 were included and compared with a control group of transplant patients who were already on renal replacement therapy. In the pre-dialysis group, patients selected had a glomerular filtration rate under 15 ml/min (measured by CKD-EPI), an estimated time to onset of dialysis under 6 months, and a post-transplant time greater than one year. Each case in the pre-dialysis group was matched by age and sex of donor and recipient, as well as by transplant date (to select the case for the control group, the time between the two transplants must be less than 7 days).</p><p id="par0050" class="elsevierStylePara elsevierViewall">The immunological status of the recipients was evaluated via donor-recipient compatibility and the preformed antibody level.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The general immunosuppressant regime at the time of the kidney transplant consisted of tacrolimus (initial dose: Prograf® 0.1 mg/kg every 12 h or Advagraf® 0.2 mg/kg per day; subsequent doses were adjusted to maintain a trough concentration of tacrolimus between 8 and 10 ng/mL during the first month and afterwards between 6 and 8 ng/mL), mycophenolate mofetil (500 mg/12 h orally) or mycophenolic acid (360 mg/12 h orally), basiliximab or timoglobulin in high-risk patients and tapered corticosteroids.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The variables evaluated were incidence of early graft loss (before 48 h), acute rejection (sudden alteration in graft function or presence of delayed graft function, with specific histological changes), delayed graft function (need for dialysis in the first week post-transplant), kidney function at 12 and 36 months (serum creatinine level), and graft and patient survival during the same period.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The period of time in the transplant waiting list in each patient group was evaluated.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Adherence to treatment was evaluated in both groups by determination of the variation in the trough tacrolimus concentration (calculated as the mean of the coefficients of variation [CV] of the trough tacrolimus concentration for the individual patients obtained from month 3 through month 24 post-transplant, expressed as a percentage) along with a personal interview conducted at every visit.<elsevierMultimedia ident="eq0005"></elsevierMultimedia></p><p id="par0075" class="elsevierStylePara elsevierViewall">The theoretical cost resulting from the care of the patients on dialysis of the control group patients was quantified using as the data source.the study conducted by Arrieta et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> The cost per patient according to the corresponding time on dialysis was calculated (months on dialysis multiplied by monthly cost depending on the technique).</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical study</span><p id="par0080" class="elsevierStylePara elsevierViewall">The continuous variables are expressed as the mean and 95% confidence interval, or median and interquartile range (p25–p75), depending on the distribution type. The categorical variables are described as the number of percentage of patients by response category.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The continuous variables were compared between groups with Student's T-test or Mann-Whitney's U test depending on the type of variable distribution. Categorical variables were analysed using Fischer's test.</p><p id="par0090" class="elsevierStylePara elsevierViewall">A survival analysis (Kaplan–Meier) was performed to analyse the percentage of patients and grafts lost during the follow-up period. Both groups were compared using the statistical test (<span class="elsevierStyleItalic">log-rank</span>). The level of significance was set at 0.05. The statistical analysis was performed with the SPSS software, version 24.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">Sixty-six (66) recipients were included in the pre-dialysis group, matched with 66 patients in the control group, 51 of them on haemodialysis and 15 on continuous outpatient peritoneal dialysis. The median follow-up (months) in the pre-dialysis and control groups was 54.0 (p25–p75: 24.0–102.0) and 56 (p25–p75: 28.8–108.3), respectively. The time on the waiting list was similar in both groups (median in months: p25–p75; 4 [2–7] vs. 6 [2–11] months; p = 0.100).</p><p id="par0100" class="elsevierStylePara elsevierViewall">No significant differences were observed between the groups in the age and sex of the donor and recipient, percentage of donors over 60 years, cold ischaemia time, and patients who received induction with thymoglobulin or basiliximab. No significant differences were also observed in the blood group of the recipients or their immunization status. The variability in the trough tacrolimus concentration was similar in both groups, with no lack of adherence detected during the interviews. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the similarity of the variables in both groups.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">In the pre-dialysis group, the incidence of delayed graft function was similar to the control group (13.6 vs. 15.2%, respectively; p = 0.804). Similarly, no statistically significant differences were found between the two groups for the presence of acute rejection (pre-dialysis group: 12.1% vs. control group: 12.1%; p = 1.000) and early graft loss (pre-dialysis group: 4.5% vs. control group 6%; p = 0.890). Kidney function, evaluated by median serum creatinine, was similar in the pre-dialysis and control groups at one year (1.5 vs. 1.5 mg/dL, respectively; p = 0.568) and 3 years (1.5 vs. 1.4 mg/dL; p = 0.808) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Recipient survival at one and 5 years was 98.5% and 88.3% in the pre-dialysis group and 95.5% and 83.0% in the control group, respectively (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Similarly, graft survival in the pre-dialysis group was 87.8% at one year and 78.2% at 5 years, and in the control group it was 89.4% at one year and 72.5% at 5 years (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The mean recipient survival time was not different in the pre-dialysis and control groups (126.8 [95% CI: 113.8–139.8] vs. 123.1 [95% CI: 109.7–135.5]) months, respectively; p = 0.730) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Nor were significant differences in the graft survival time observed between the two groups (pre-dialysis group: 114.6 months [95% CI: 99.1–130.2] vs. control group: 109.3 months [95% CI: 93.7–124.8]; p = 0.693) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><p id="par0120" class="elsevierStylePara elsevierViewall">Taking into account the total time on peritoneal dialysis (334 months) and haemodialysis (1834 months), the total cost of renal replacement therapy in our patients was 8,033,893.16 Euros.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">The worldwide experience with pre-emptive, deceased-donor kidney transplant is scarce and under debate.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Some authors have reported that the time on dialysis before kidney transplantation has a negative impact on its outcome, therefore performing it pre-emptively would be associated with greater graft and recipient survival as compared to patients who remained on dialysis for some time.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6,8,16–18</span></a> Studies by Roake et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and Papalois et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> have demonstrated superior survival in pre-dialysis recipients. These results were recently supported by a French multi-centre studied by Prezelin–Reydit in which it was concluded that pre-emptive transplant is associated with a lower risk of graft failure. Nevertheless, this conclusion may be conditional, by having an older dialysis patient group with greater cardiovascular comorbidity and a higher percentage of diabetes mellitus patients than the pre-emptive transplant group, and the fact that the grafts come from older donors.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Other authors such as Luo et al. recommend this type of transplant, since they improve the patient's quality of life and reduce the economic cost, despite not observing significant differences in terms of recipient or graft survival. However, these authors did show evidence of a decreased rate of acute rejection.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In our study, like in that by Luo et al.,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> we did not find significant differences in recipient and graft survival rate. Foucher et al. reached the same conclusion in a recent study designed with a control group of more than 500 patients included in the waiting list for at least 6 months before their first dialysis session; in addition, they used an inverse probability score to make the groups mor homogeneous. Nevertheless, the dialysis group had a significantly higher percentage of hyperimmunised patients that were treated with more immunosuppression, which could alter the results.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">The percentage of recipients who experienced acute rejection was similar in both groups, which contrasts with the previously mentioned study by Luo et al. and other studies cited in the literature, which show that a longer time on dialysis increases the risk of rejection.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> The study by Cacciarelli, with 325 kidney transplants, concluded that the incidence of acute rejection was lower in patients who remained on dialysis for a period less than 6 months.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> In contrast, it has been proposed that patients who have not experienced the symptoms of CKD or the morbidity associated with dialysis may be less compliant with the immunosuppressant treatment<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>, which would lead to a higher incidence of rejection. It is worth to mention that in our group of recipients with pre-emptive transplant, there was no evidence of no compliance in any patient, a similar result was obtained by Papalois, who did not find a higher rate of non-adherence to treatment in patients who received pre-emptive kidney transplant.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Kidney function 12 and 36 months after the transplant was similar in both groups. However, in other studies, it is made clear that the rate of delayed kidney function is higher in transplant patients who were already on dialysis<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>; the hypothesis proposed is a higher inflammatory status, as well as an inadequate clearance of certain metabolites in these patients.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Foucher et al. exhaustively reviewed the ethical justification for transplanting patients in a pre-dialysis situation, which could lead to a longer time on the waiting list for patients on dialysis. In this study, the recipients from the dialysis group were on the waiting list for a mean time of 38 months, significantly longer (p < 0.0001) than the pre-dialysis group, with a mean time of 14 months.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Our experience is different, since the time on the waiting list in our patients is much shorter and it was not significantly different between the pre-dialysis and dialysis group: 4 and 6 months, respectively; therefore it was consider that, in our case, performing a pre-emptive, deceased-donor transplant does not constitute an ethical dilemma.</p><p id="par0150" class="elsevierStylePara elsevierViewall">The peculiarity of our work is based in the fact that in the analysis of the variables studied, matching were made between pairs of recipients (pre-dialysis situation vs. recipients already on dialysis) who were transplanted with a narrow time margin (under 7 days); whereas in the other referenced series,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,16–18</span></a> the group of recipients in a pre-dialysis situation constituted a sub-group of their transplant populations, without matching in terms of transplant time.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Regarding the economicl cost, it is worth to mention that renal replacement therapy (haemodialysis, peritoneal dialysis, and kidney transplant) consume 2.5% of the National Health System's budget and more the 4% of that for Specialised Care. The mean cost of haemodialysis, peritoneal dialysis, and kidney transplant first year is 46,660, 32,432, and 47,136 Euros per patient per year, respectively. However, in subsequent years, the cost of the kidney transplant decreases considerably: 6477 Euros per patient per year; transplant is the technique with the best cost-effectiveness ratio<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>; therefore we can affirm that it not only prolongs life, but that as far as the economical cost it is also an more advantageous option as compared with long-term dialysis.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Thus, the time on dialysis for the recipients in the control group entailed a cost which could have been reduced in the case of pre-emptive transplant; this is an objective data point which should be added to the subjective benefit for the patient by avoiding dialysis and, prior to this, inserting the access points.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> However, it is necessary to call attention to the limited availability of deceased-donor kidneys,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8,16</span></a> a fact which would significantly limit the implementation of the proposed strategy.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Deceased-donor kidney transplant offers patients in a pre-dialysis situation outcomes which are at least comparable to those of recipients on dialysis and prevents the morbidity, mortality and psychological impact derived from dialysis, in additional to being economically advantageous.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1318546" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1216583" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1318547" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Materiales y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1216582" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical study" ] ] ] 6 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-10-17" "fechaAceptado" => "2019-04-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1216583" "palabras" => array:5 [ 0 => "Pre-emptive renal transplant" 1 => "Deceased donor" 2 => "Patient and graft survival" 3 => "Dialysis" 4 => "Psychological aspects" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1216582" "palabras" => array:5 [ 0 => "Trasplante renal anticipado" 1 => "Donante cadáver" 2 => "Supervivencia injerto y receptor" 3 => "Diálisis" 4 => "Impacto psicológico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Currently, kidney transplantation is the treatment of choice for patients with kidney disease who require replacement therapy. Dialysis is a necessary step, but not mandatory prior to transplantation. There is the possibility of pre-emptive transplantation or transplantation in pre-dialysis, that is, without previous dialysis. The aim of the present study is to evaluate the result of our experience with a pre-emptive kidney transplant from a deceased donor.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Retrospective, observational, matched cohort study. We compared 66 pre-emptive with 66 non pre-emptive recipients, who received a first renal graft performed at our centre, matched by age and gender of donors and recipients, time of transplant, immunological risk, immunosuppression and cold ischaemia time.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Early graft loss, incidence of acute rejection, delayed graft function, renal function at 12 and 36 months and graft and recipient survival were assessed in this period.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The percentage of recipients who presented early graft loss, delayed graft function and acute rejection was similar in both groups. No differences were observed in their renal function at 12 and 36 months after transplantation, as well as the actuarial survival of patients (p = 0.801) and grafts (p = 0.693) in the studied period. The total calculated cost of the period on dialysis for the control group was 8,033,893.16 euros.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Pre-emptive transplantation can yield comparable outcomes to those for post-dialysis kidney transplantation, and results in better quality of life for patients with end-stage kidney disease, as well as a reduced cost.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Actualmente, el trasplante renal es el tratamiento de elección para pacientes con enfermedad renal que requieren terapia de sustitución. La diálisis es un paso necesario, pero no obligatorio, previo al trasplante. Existe la posibilidad del trasplante renal anticipado o en pre-diálisis, es decir, sin diálisis previa. El objetivo del presente estudio es evaluar el resultado de nuestra experiencia en el trasplante renal anticipado con donante cadáver.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y métodos</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional retrospectivo de tipo cohortes emparejadas. Seincluyó a 66 receptores de trasplante renal en situación pre-diálisis, frente a un grupo control de 66 pacientes ya en diálisis que recibieron un primer injerto renal, emparejados por edad y sexo de donante y receptor, momento del trasplante, riesgo inmunológico, inmunosupresión y tiempo de isquemia fría. Se evaluó la pérdida precoz del injerto, incidencia de rechazo agudo, función retrasada del injerto, función renal a los 12 y 36 meses y supervivencia de injerto y receptor en ese periodo.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de receptores que presentaron pérdida precoz del injerto, función retrasada del injerto y rechazo agudo fue similar en ambos grupos. Tampoco se observaron diferencias en la función renal a los 12 ni a los 36 meses después del trasplante, ni en lasupervivencia actuarial de pacientes (p = 0,801) e injertos (p = 0,693).</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">El coste total del tratamiento renal sustitutivo en el grupo control fue: 8033893.16 euros.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">El trasplante renal de donante cadáver ofrece a los pacientes en situación de prediálisis resultados superponibles a los de receptores en diálisis, además de ser económicamente rentable.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Materiales y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Franco A, et al. Una aproximación al trasplante renal anticipado de donante cadáver. Estudio de cohortes emparejadas. Nefrologia. 2020;40:32–37.</p>" ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 785 "Ancho" => 1449 "Tamanyo" => 68448 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Kidney transplant recipient survival in the pre-dialysis and control groups (<span class="elsevierStyleItalic">log-rank</span>; p = 0.730).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 743 "Ancho" => 1443 "Tamanyo" => 68072 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Kidney transplant graft survival in the pre-dialysis and control groups (<span class="elsevierStyleItalic">log-rank</span>; p = 0.693).</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cp TAC: trough tacrolimus concentration; CV: coefficient of variation; HLA: histocompatibility antigens; 95% CI: 95% confidence interval; PRA: panel-reactive antibody; M/F: male/female.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pre-dialysis group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Donor age (years), mean (</span>95% <span class="elsevierStyleItalic">CI)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.1 (49.1–55.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.9 (48.4–55.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.907 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Recipient age (years), mean (</span>95% <span class="elsevierStyleItalic">CI)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.8 (49.0–54.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.2 (48.0–54.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.766 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Donor sex (%M/F)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.6/36.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.1/43.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.375 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Recipient sex (%M/F)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.1/37.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.1/37.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.359 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Donor >60 years (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Cold ischaemia time (hours), mean (95% CI)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.7 (15.4–18.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.9 (15.9–17.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.826 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Thymoglobulin (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.285 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Basiliximab (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.394 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Cp TAC Variability; CV (%), median (p25-p75)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.1 (19.5–33.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.1 (19.1–44.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.602 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Blood group</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.520 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>O \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">HLA incompatibility</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.862 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4–6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0–3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">PRA ></span>50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.244 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2260072.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Demographic data of the patients included in the pre-dialysis group and control group.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pre-dialysis group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Delayed graft function (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.804 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Acute rejection (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Early graft loss (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.890 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Serum creatinine at 12 months, median (p25–p75) mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5 (1.3–1.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5 (1.1–1.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.568 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Serum creatinine at 36 months, median (p25–p75) mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5 (1.15–1.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4 (1.1–2.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.808 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2260071.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Efficacy and safety variables in the pre-dialysis group and control group (p25–p75: 25th and 75th percentile of the median).</p>" ] ] 4 => array:5 [ "identificador" => "eq0005" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:5 [ "Matematica" => "CV%=Standard deviationMean×100" "Fichero" => "STRIPIN_si1.jpeg" "Tamanyo" => 3355 "Alto" => 33 "Ancho" => 260 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular complications of chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. 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"fecha" => "2008" "volumen" => "28" "paginaInicial" => "123" "paginaFinal" => "128" "itemHostRev" => array:3 [ "pii" => "S0015028208041332" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pre-emptive kidney transplantation: the attractive alternative" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 8 | 18 |
| 2024 October | 38 | 43 | 81 |
| 2024 September | 73 | 33 | 106 |
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| 2024 January | 22 | 33 | 55 |
| 2023 December | 33 | 29 | 62 |
| 2023 November | 66 | 35 | 101 |
| 2023 October | 63 | 39 | 102 |
| 2023 September | 26 | 31 | 57 |
| 2023 August | 32 | 26 | 58 |
| 2023 July | 28 | 27 | 55 |
| 2023 June | 36 | 33 | 69 |
| 2023 May | 53 | 33 | 86 |
| 2023 April | 31 | 19 | 50 |
| 2023 March | 51 | 24 | 75 |
| 2023 February | 40 | 25 | 65 |
| 2023 January | 39 | 28 | 67 |
| 2022 December | 54 | 36 | 90 |
| 2022 November | 60 | 46 | 106 |
| 2022 October | 70 | 48 | 118 |
| 2022 September | 42 | 40 | 82 |
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| 2022 June | 38 | 34 | 72 |
| 2022 May | 49 | 37 | 86 |
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| 2021 December | 53 | 48 | 101 |
| 2021 November | 41 | 31 | 72 |
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| 2021 April | 159 | 68 | 227 |
| 2021 March | 59 | 33 | 92 |
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| 2021 January | 51 | 24 | 75 |
| 2020 December | 39 | 18 | 57 |
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| 2020 October | 26 | 24 | 50 |
| 2020 September | 34 | 20 | 54 |
| 2020 August | 20 | 15 | 35 |
| 2020 July | 28 | 11 | 39 |
| 2020 June | 22 | 11 | 33 |
| 2020 May | 45 | 16 | 61 |
| 2020 April | 51 | 22 | 73 |
| 2020 March | 29 | 13 | 42 |
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