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uric acid 7&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; cholesterol 257<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; systematic urine with minimal microhematuria&#59; MAu&#47;Cru 3371&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;g and proteinuria of 6&#46;21<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h of mixed type&#46; Negative viral serology&#46; Negative immunology tests including complement&#44; ANA&#44; ANCA&#44; anti-DN&#44; anti-phospholipase and anti-PLA2R antibodies&#46; Immunoglobulins and proteinogram were normal&#46; Abdominal ultrasound with kidneys of conserved size and bilateral diffuse hyper echogenicity as the only finding that that was noteworthy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since 1960&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> it has been known that between 30 and 50&#37; of cyanotic heart diseases can be the cause of a secondary glomerulopathy known as cyanosis nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a> It is a correlate of cardiorenal syndrome type 2&#46; It is produced trough to different mechanisms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">3&#8211;5</span></a> initiated by hyperviscosity syndrome secondary to extreme polycythemia and cyanosis&#44; which cause an increase in shear stress by passing a high number of red blood cells through the capillary unit in the glomerulus&#46; The subsequent decrease in renal blood flow and filtration fraction induce hypoxia&#44; with an angiogenic response mediated by the release of nitric oxide&#44; selective vasodilatation of the afferent arteriole and increased capillary pressure&#44; which determines glomerular hyperfiltration&#46; The decrease in peritubular capillary blood flow also contributes to increase in capillary pressure&#46; In parallel&#44; cyanosis triggers an angiogenic stimulus with an increase in the number of capillaries per glomerulus&#44; glomerulomegaly due to endothelial proliferation and an increase in the surface area of the glomerular capillary&#44; the podocyte stretches and it is hypertrophied due to stress and there is a damage that mimics glomerulonephritis due to minimal changes and subsequently to segmental glomerulosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">It is accepted that the initial damage is in the tubule&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7&#8211;9</span></a> especially in the proximal tubule&#44; as reflected by an increase in urinary N-acetyl glucosamine and &#945;1-microglobulin that usually occurs in the first decade of life and continue in the next decade with a glomerular damage &#40;albuminuria&#44; proteinuria and decrease in glomerular filtration&#41;&#46; As the mechanism of compensating glomerular hyperfiltration is exhausted&#44; a glomerular hyalinosis develops with glomerulosclerosis and interstitial fibrosis that will condition the midterm prognosis&#46; A different injury is distinguished in small vessels resulting from capillary dilation&#44; thickening or endothelial destruction&#44; glomerulosclerosis and periglomerular fibrosis mediated by a non-vascular proliferative mechanism&#44; resulting from the shunt in the pulmonary circulation&#46; Under normal conditions&#44; after being released from the spleen and bone marrow&#44; a population of megakaryocytes are retained in the interstitium and in the pulmonary vasculature<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;10&#44;11</span></a> where they disaggregate forming active platelets at a rate of 10<span class="elsevierStyleSup">6</span>&#47;h&#46; However in conditions of right&#47;left shunt this step is avoided and the megakaryocytes pass intact to the systemic circulation making possible that their alpha granules&#44; rich in PDGF and in TGF&#946;&#44; reach the renal glomerulus and be released&#44; producing 2 effects&#46; A peripheral thrombocytopenia that indirectly quantifies the degree of shunt &#40;the greater thrombocytopenia&#44; the greater shunt&#41; and an increase of proliferative platelet factors that will cause an increase in mesangial juxtaglomerular cells&#44; mesangial matrix and focal interstitial fibrosis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The hematocrit level&#44; the delay until shunt surgery and a platelet level of less than 250&#44;000&#47;ml are risk factors for the appearance of nephropathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">3&#44;12&#44;13</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The treatment consists of reducing surgical waiting times&#44; periodic phlebotomies and inhibition of the renin&#8211;angiotensin&#8211;aldosterone axis with ACE inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Renal prognosis is unfavorable if the cause is not resolved&#46; In our case&#44; we began treatment with statins and ACEIs&#44; and periodic phlebotomies were again recommended without sufficient follow-up to evaluate the response at the present time&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ortega-D&#237;az M&#44; Puerta Carretero M&#44; Corchete E&#44; Mart&#237;n Navarro JA&#44; Jaldo MT&#44; Albalate M&#44; et al&#46; Nefropat&#237;a por cianosis&#46; A prop&#243;sito de un caso&#46; Nefrologia&#46; 2019&#59;39&#58;96&#8211;98&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pathophysiology of cyanotic nephropathy&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">FF&#58; filtration fraction&#59; RBF&#58; renal blood flow&#59; FSGE&#58; focal and segmental glomerulosclerosis&#59; GLM&#58; glomerulus&#59; MCGN&#58; minimal change glomerulonephritis&#59; GHF&#58; glomerular hyperfiltration&#59; HT&#58; hypertrophy&#59; PDGF&#58; platelet derived growth factor&#59; PCT&#58; proximal convoluted tubule&#59; TGF&#946;&#58; tumor growth factor &#946;&#59; AA VSD&#58; arteriolar afferent vasodilation&#46;</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Continuous line&#58; pathway of vascular damage&#59; broken line&#58; path of proliferative damage&#59; double grid&#58; path of final damage&#46;</p>"
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Letter to the Editor
A case report of cyanotic nephropathy
Nefropatía por cianosis. A propósito de un caso
Mayra Ortega-Díaz, Marta Puerta Carretero, Elena Corchete, Juan A. Martín Navarro
Corresponding author
juanmartinnav@hotmail.com

Corresponding author.
, M. Teresa Jaldo, Marta Albalate, Patricia de Sequera, Roberto Alcázar Arroyo
Servicio de Nefrología, Hospital Universitario Infanta Leonor, Madrid, Spain
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Moderate thrombocytopenia and transient ischemic attack 10 years earlier&#44; after which antiaggregation with ASA was replaced by clopidogrel&#46; Regular treatment included clopidogrel&#44; allopurinol and bosentan&#46; In addition&#44; he had periodic phlebotomies until 2 years ago when they were suspended at the discretion of their cardiologists&#46; The patient consulted for a proteinuria of unknown time of evolution&#46; Normal blood pressure with a BMI of 23<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; In the analytic&#44; Cr 0&#46;78<span class="elsevierStyleHsp" style=""></span>mg&#47;dl with estimated glomerular filtration rate by CKD-EPI greater than 90<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; Hb 23&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#59; Hct of 80&#46;8&#37;&#59; platelets 89&#44;000&#47;ml&#59; uric acid 7&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; cholesterol 257<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#59; systematic urine with minimal microhematuria&#59; MAu&#47;Cru 3371&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;g and proteinuria of 6&#46;21<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h of mixed type&#46; Negative viral serology&#46; Negative immunology tests including complement&#44; ANA&#44; ANCA&#44; anti-DN&#44; anti-phospholipase and anti-PLA2R antibodies&#46; Immunoglobulins and proteinogram were normal&#46; Abdominal ultrasound with kidneys of conserved size and bilateral diffuse hyper echogenicity as the only finding that that was noteworthy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since 1960&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a> it has been known that between 30 and 50&#37; of cyanotic heart diseases can be the cause of a secondary glomerulopathy known as cyanosis nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a> It is a correlate of cardiorenal syndrome type 2&#46; It is produced trough to different mechanisms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">3&#8211;5</span></a> initiated by hyperviscosity syndrome secondary to extreme polycythemia and cyanosis&#44; which cause an increase in shear stress by passing a high number of red blood cells through the capillary unit in the glomerulus&#46; The subsequent decrease in renal blood flow and filtration fraction induce hypoxia&#44; with an angiogenic response mediated by the release of nitric oxide&#44; selective vasodilatation of the afferent arteriole and increased capillary pressure&#44; which determines glomerular hyperfiltration&#46; The decrease in peritubular capillary blood flow also contributes to increase in capillary pressure&#46; In parallel&#44; cyanosis triggers an angiogenic stimulus with an increase in the number of capillaries per glomerulus&#44; glomerulomegaly due to endothelial proliferation and an increase in the surface area of the glomerular capillary&#44; the podocyte stretches and it is hypertrophied due to stress and there is a damage that mimics glomerulonephritis due to minimal changes and subsequently to segmental glomerulosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">It is accepted that the initial damage is in the tubule&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7&#8211;9</span></a> especially in the proximal tubule&#44; as reflected by an increase in urinary N-acetyl glucosamine and &#945;1-microglobulin that usually occurs in the first decade of life and continue in the next decade with a glomerular damage &#40;albuminuria&#44; proteinuria and decrease in glomerular filtration&#41;&#46; As the mechanism of compensating glomerular hyperfiltration is exhausted&#44; a glomerular hyalinosis develops with glomerulosclerosis and interstitial fibrosis that will condition the midterm prognosis&#46; A different injury is distinguished in small vessels resulting from capillary dilation&#44; thickening or endothelial destruction&#44; glomerulosclerosis and periglomerular fibrosis mediated by a non-vascular proliferative mechanism&#44; resulting from the shunt in the pulmonary circulation&#46; Under normal conditions&#44; after being released from the spleen and bone marrow&#44; a population of megakaryocytes are retained in the interstitium and in the pulmonary vasculature<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;10&#44;11</span></a> where they disaggregate forming active platelets at a rate of 10<span class="elsevierStyleSup">6</span>&#47;h&#46; However in conditions of right&#47;left shunt this step is avoided and the megakaryocytes pass intact to the systemic circulation making possible that their alpha granules&#44; rich in PDGF and in TGF&#946;&#44; reach the renal glomerulus and be released&#44; producing 2 effects&#46; A peripheral thrombocytopenia that indirectly quantifies the degree of shunt &#40;the greater thrombocytopenia&#44; the greater shunt&#41; and an increase of proliferative platelet factors that will cause an increase in mesangial juxtaglomerular cells&#44; mesangial matrix and focal interstitial fibrosis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The hematocrit level&#44; the delay until shunt surgery and a platelet level of less than 250&#44;000&#47;ml are risk factors for the appearance of nephropathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">3&#44;12&#44;13</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The treatment consists of reducing surgical waiting times&#44; periodic phlebotomies and inhibition of the renin&#8211;angiotensin&#8211;aldosterone axis with ACE inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Renal prognosis is unfavorable if the cause is not resolved&#46; In our case&#44; we began treatment with statins and ACEIs&#44; and periodic phlebotomies were again recommended without sufficient follow-up to evaluate the response at the present time&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ortega-D&#237;az M&#44; Puerta Carretero M&#44; Corchete E&#44; Mart&#237;n Navarro JA&#44; Jaldo MT&#44; Albalate M&#44; et al&#46; Nefropat&#237;a por cianosis&#46; A prop&#243;sito de un caso&#46; Nefrologia&#46; 2019&#59;39&#58;96&#8211;98&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Pathophysiology of cyanotic nephropathy&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">FF&#58; filtration fraction&#59; RBF&#58; renal blood flow&#59; FSGE&#58; focal and segmental glomerulosclerosis&#59; GLM&#58; glomerulus&#59; MCGN&#58; minimal change glomerulonephritis&#59; GHF&#58; glomerular hyperfiltration&#59; HT&#58; hypertrophy&#59; PDGF&#58; platelet derived growth factor&#59; PCT&#58; proximal convoluted tubule&#59; TGF&#946;&#58; tumor growth factor &#946;&#59; AA VSD&#58; arteriolar afferent vasodilation&#46;</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Continuous line&#58; pathway of vascular damage&#59; broken line&#58; path of proliferative damage&#59; double grid&#58; path of final damage&#46;</p>"
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Article information
ISSN: 20132514
Original language: English
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2024 February 89 43 132
2024 January 84 31 115
2023 December 75 40 115
2023 November 112 57 169
2023 October 84 87 171
2023 September 100 75 175
2023 August 91 31 122
2023 July 111 63 174
2023 June 109 33 142
2023 May 205 55 260
2023 April 144 55 199
2023 March 139 44 183
2023 February 105 42 147
2023 January 102 44 146
2022 December 153 73 226
2022 November 140 45 185
2022 October 130 54 184
2022 September 86 58 144
2022 August 87 41 128
2022 July 100 69 169
2022 June 105 58 163
2022 May 108 34 142
2022 April 111 55 166
2022 March 89 65 154
2022 February 95 55 150
2022 January 127 49 176
2021 December 91 66 157
2021 November 113 52 165
2021 October 117 69 186
2021 September 94 58 152
2021 August 71 66 137
2021 July 93 43 136
2021 June 78 44 122
2021 May 67 45 112
2021 April 291 163 454
2021 March 134 54 188
2021 February 109 46 155
2021 January 63 32 95
2020 December 61 28 89
2020 November 78 27 105
2020 October 73 25 98
2020 September 81 30 111
2020 August 43 26 69
2020 July 52 16 68
2020 June 67 38 105
2020 May 59 48 107
2020 April 130 27 157
2020 March 51 20 71
2020 February 88 33 121
2020 January 111 44 155
2019 December 70 38 108
2019 November 61 39 100
2019 October 69 26 95
2019 September 55 25 80
2019 August 42 14 56
2019 July 48 33 81
2019 June 57 27 84
2019 May 51 29 80
2019 April 60 45 105
2019 March 36 37 73
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?