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the validation of DXA as a reference diagnostic technique in the renal population has not been fully established&#44; so it is not performed as a routine in clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We have reviewed the various diagnostic strategies to evaluate bone health in renal patients&#44; with special interest in the kidney transplant &#40;KT&#41; recipient&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Justification&#58; bone disease and fractures after kidney transplantation</span><p id="par0015" class="elsevierStylePara elsevierViewall">The bone mineral disease in CKD patients is characterized by abnormalities in bone turnover&#44; mineralization and bone density&#44; which cause bone fragility and an increased risk of fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the transplant patient&#44; bone disease has its own peculiarities that are associated to the recovery of renal function&#44; persistent hyperparathyroidism<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and immunosuppressive treatment which is inherent in the transplant process&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The main alteration in bone remodeling after renal transplantation is the reduction in bone formation and mineralization&#44; with a persistent predominance of resorption&#46; In fact&#44; during the first 6 months after transplantation&#44; there is a rapid decrease in BMD&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which is subsequently attenuated&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> most likely related to the decrease in the dose of steroids&#46; As a result&#44; a high risk of fracture has been described in patients after KT &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;23</span></a> which&#44; initially&#44; is even higher than that in dialysis patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In addition&#44; it has been proven that this increase in risk persists in the late post-transplant period&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">State of the art&#58; diagnosis of bone disease in the kidney transplant patient</span><p id="par0025" class="elsevierStylePara elsevierViewall">Evaluation of bone health in the renal patient is key to estimate the risk of fracture&#46; Laboratory measurements such as bone remodeling markers&#44; or invasive procedures such as bone biopsy are available for assessment of bone health&#44; but it is not clear which diagnostic tests best predict the risk of fracture&#46; Unlike in the general population&#44; risk scales or DXA have a much more limited predictive power&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To establish the accurate diagnosis of bone disease&#44; it is necessary to understand the different properties contributing bone resistance&#46; Bone quantity is determined by BMD and expressed as grams of mineral per bone area &#40;or volume if measured by computed tomography&#41;&#46; In a given individual&#44; it is determined by the maximum bone mass achieved and the rate of bone loss&#46; Other aspects of bone quality also contribute to the bone mechanical strength&#58; the spatial distribution of bone at the macroscopic &#40;geometry&#41; and microscopic &#40;microarchitecture&#41; level&#44; and the composition of the bone tissue itself&#46; The spatial distribution of bone can be determined by different imaging techniques&#44; from simple radiography to high-resolution tomography or magnetic resonance&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> The higher the image resolution&#44; the better the estimation of microscopic bone structure&#46; In addition&#44; the physical&#44; chemical and biological components of the bone tissue are equally relevant for bone strength and mechanical performance of the bone&#44; including characteristics of collagen&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> degree and homogenization of mineralization<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> and non-collagenous proteins&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">There are different techniques that provide information on the different bone properties that help to make the diagnosis of bone disease after kidney transplantation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Bone X-ray can identify lesions that are characteristic of renal osteodystrophy&#44; but these changes occur very late&#46; Its main diagnostic value is the ability to detect asymptomatic vertebral fractures&#44; a fact that predisposes to suffer a osteoporotic fracture of greater magnitude&#46; This helps to select a population with a higher risk of fracture&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Among CKD patients it is not common to use the Fracture Risk Assessment Tool &#40;FRAX&#41;&#44; which estimates the probability at 10 years of major osteoporotic fracture &#40;clinical vertebral&#44; hip&#44; forearm and humerus&#41; applying an algorithm based on age&#44; gender and clinical factors &#40;with or without BMD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Therefore the predictive capacity of FRAX in this population is unknown&#46; In a recent study&#44; the FRAX score was applied to KT patients with a mean of 1&#46;1 years after transplantation&#46; Most of them were categorized as having a &#8220;low risk&#8221; of fracture at 10 years&#44; showing a modest predictive power of the score since 4&#46;6&#37; of patients had a fracture at 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">DXA is currently the standard method to determine BMD in the general population and is used for screening for osteoporosis in CKD patients&#46; It provides information about the total amount of mineral in the scanned bone area &#8211; usually the neck of the femur and the vertebrae &#8211; although it does not distinguish changes in bone turnover or characteristics of the bone matrix&#46; In patients with CKD&#44; tissue or vascular calcifications may interfere with bone measurements and give falsely elevated values&#46; Likewise&#44; post-transplant calcium mobilization could lower BMD values&#44; without actually changing the bone mineral content&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In patients with CKD stages 3&#8211;5D&#44; it is not recommended the routine performance of DXA for determination of BMD&#44; due to its low predictive power of fractures and its inability to diagnose the type of renal osteodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In CKD patients&#44; lumbar or hip BMD can be misleading and may lead to inadequate administration of antiresorptive drugs&#46; The best location for BMD measurement is the distal radius&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Even with these limitations&#44; renal patients with lower BMD at the lumbar and femoral neck have the highest incidence of fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">However&#44; DXA cannot detect other bone properties of bone strength that are relevant to predict the risk of fracture&#44; such as bone trabecular microarchitecture<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> or other mechanical properties such as elasticity&#44; trabecular spatial arrangement or the quality of the collagen matrix that are&#44; also determinants of bone resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The bone biopsy the gold-standard diagnostic test to establish the patients bone health&#44; but it is invasive&#44; laborious and expensive&#44; consequently it is used very infrequently in clinical practice&#46; Thus given that DXA is not able to fully detect bone resistance to fractures&#44; additional diagnostic tests are needed to establish the risk of fracture&#46; Three diagnostic tests have emerged in recent years&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall">High resolution peripheral quantitative computer tomography&#44; used in patients with CKD&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> or KT<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> measures the volumetric density of the cortical and trabecular region separately&#44; and has a resolution that allows analyzing the bone microarchitecture&#46; However&#44; it is expensive and so far not very accessible in usual practice&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">The trabecular bone score &#40;TBS&#41;&#44; analyzes the trabecular bone microarchitecture in the lumbar spine using specific software in images obtained with DXA&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Abnormal trabecular microarchitecture at the vertebral level has been associated with an increased risk of fracture&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Lower TBS values have been described in the hemodialysis population<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> and in Kidney transplant patients &#8211; in the early post-transplant &#8211; with respect to the general population&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> with the risk of fracture that this entails&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">Bone microindentation is a technique capable of directly measuring mechanical properties of bone at the tissue level&#46; This was first described in a clinical series in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> It is based on microscopic indentation&#44; which measures the resistance of the cortical bone to the opening of microscopic fractures or micro-fractures&#44; a phenomenon intimately linked to the beginning of the solution of continuity in the bone that gives rise to the fracture&#46; To date&#44; 2 main techniques have been developed&#58; cyclical microindentation and impact microindentation&#46; Both are included in the generic term of reference point indentation and are based on the principle that the deeper a needle penetrates the anterior face of the tibia&#44; the less resistant the bone tissue will be to a mechanic impact&#46; The cyclic microindentation was used in the first studies including patients<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#59; the study by impact microindentation&#44; simplifies the method of measurement<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#8211;39</span></a> and makes it preferable for clinical use&#46; The procedure is simple&#46; It is performed on the anterior face of the tibia with an indenting handheld device&#44; Osteoprobe<span class="elsevierStyleSup">&#174;</span> &#40;Active Life Scientific&#44; Santa Barbara&#44; CA&#44; USA&#41;&#46; After administering local anesthesia at the puncture site&#44; a preload of 10<span class="elsevierStyleHsp" style=""></span>N of force followed by an indentation of 30<span class="elsevierStyleHsp" style=""></span>N using a conical needle of 4<span class="elsevierStyleHsp" style=""></span>&#956;m is applied&#46; The mean of 8 indentation values is transformed by a computerized algorithm&#46; Then&#44; 5 calibration indentations are made in a block of polymethyl methacrylate&#46; The ratio between the value provided by the bone and by the block provides the final parameter&#44; the bone mineral resistance index&#44; which is expressed in absolute units&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">The propensity to bone fractures is the result of the deterioration of BMD&#44; microarchitecture and bone tissue properties&#44; which can occur individually or in combination and in different proportions depending on each pathophysiological situation&#46; Therefore&#44; for a complete calculation we must contemplate the 3 components&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Impact microindentation has been applied in the study of other patient populations in which the risk of fracture can only be partially established with DXA&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#8211;39</span></a> There are situations&#44; such as in elderly women&#44; where microindentation does not seem to add value to the prediction of risk of fracture&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> perhaps because it is a population in which BMD and microarchitecture&#44; are already very deteriorated playing a predominant role in the loss of bone strength&#46; By contrast&#44; in women with type 2 diabetes&#44; where both BMD and trabecular microarchitecture are preserved while the risk of fracture is clearly high&#44; the bone mineral resistance index was the most abnormal component of bone strength&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Therefore&#44; microindentation can be a complement to the existing bone analysis methods&#44; particularly in populations where BMD does not satisfactorily explain the propensity to fracture&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The best method to estimate the risk of fracture in a patient with CKD is unknown&#46; An improvement of the diagnostic methods to determine the risk of fracture is crucial as a first step for the indication of any preventive treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Bone health in the long-term kidney transplant patient</span><p id="par0100" class="elsevierStylePara elsevierViewall">In our group&#44; we aimed to analyze the bone health of a cohort of long term kidney transplant patients&#44; taking into account different bone properties that contribute to bone strength&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> So we performed a case&#8211;control study&#44; in KT patients of more than 10 years of follow up and healthy controls without kidney disease or any relevant factor that may affect bone health&#46; The transplant patients had a lower BMD than healthy controls&#46; However&#44; the trabecular microarchitecture estimated by TBS and the bone tissue quality measured by microindentation were comparable in both groups&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In renal transplant patients&#44; the TBS is lower than in the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> However&#44; this study analyzed TBS in the early post-transplant&#44; this is in contrast with our KT patients of more than 10 years of evolution that showed values of TBS similar to controls suggesting a recuperation of bone health after years post transplantation&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Additionally&#44; we performed bone microindentation tests for the first time in subjects with kidney disease and our patients presented bone strength values similar to those of healthy controls&#46; This indicates that the bone affectation in this transplanted population of long evolution is no longer very relevant since values of bone quality of these receptors are similar to the general population&#46; In addition&#44; these results are in agreement with studies showing that bone changes in the post-transplant period are temporary and revert with a fast reduction or suspension of glucocorticoids&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;42</span></a> In this regard&#44; it is noteworthy that 80&#37; of our cohort did not have glucocorticoids as a base immunosuppressive treatment at the time of the study&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Therefore&#44; in general terms&#44; the results obtained showed bone normalization in the late post-transplant&#44; despite the fact that the BMD values were lower than those of the healthy controls&#46; As far as we know&#44; this is the first study that assesses bone health in KT&#44; taking into account all its different components&#58; bone quantity&#44; trabecular microstructure and bone tissue quality&#46; Therefore this is the first study performed in renal patients which includes measurement of bone quality by means of microindentation which evaluates mechanical properties of the bone providing additional information about bone resistance using a method that is simple and clinically viable&#46; However&#44; longitudinal studies with an appropriate number of patients will be necessary to determine the value of bone microindentation to predict the risk of fracture in this population&#44; and to define the value of microindentation to monitor bone mineral resistance index in response to different therapeutic strategies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="par0120" class="elsevierStylePara elsevierViewall">The predisposition to fracture is determined by bone resistance which results from several bone properties that complement each other and can be evaluated separately with different diagnostic tests&#46; To estimate risk fracture adequately&#44; both bone quantity and quality must be evaluated&#46; Among renal patients&#44; those with kidney transplant require complete evaluation of bone characteristics so optimal preventive intervention is applied&#46; Results from TBS and bone microindentation have been associated with an increased risk of fractures in other populations&#44; although additional prospective studies including large number of patients and longer follow-up will confirm the clinical usefulness of these techniques and their ability to predict bone fractures&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">The DPA institution has received funds for research scholarships from AMGEN and BIOIBERICA&#46; ADP is a shareholder of Active Life Scientific&#46; The rest of the authors declare no conflict of interests&#46;</p></span></span>"
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          "titulo" => "Justification&#58; bone disease and fractures after kidney transplantation"
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          "titulo" => "State of the art&#58; diagnosis of bone disease in the kidney transplant patient"
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          "titulo" => "Bone health in the long-term kidney transplant patient"
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          "titulo" => "Conclusions"
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          "titulo" => "Conflict of interests"
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            0 => "Bone mineral disease"
            1 => "Kidney transplant"
            2 => "Fractures"
            3 => "Bone strength"
            4 => "Trabecular bone score"
            5 => "Bone microindentation"
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            0 => "Enfermedad mineral &#243;sea"
            1 => "Trasplante renal"
            2 => "Fracturas"
            3 => "Resistencia &#243;sea"
            4 => "Score trabecular &#243;seo"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bone disease related to chronic kidney disease and&#44; particularly&#44; to kidney transplant patients is a common cause or morbidity and mortality&#44; especially due to a higher risk of osteoporotic fractures&#46; Despite the fact that this has been known for decades&#44; to date&#44; an appropriate diagnostic strategy has yet to be established&#46; Apart from bone biopsy&#44; which is invasive and scarcely used&#44; no other technique is available to accurately establish the risk of fracture in kidney patients&#46; Techniques applied to the general population&#44; such as bone densitometry&#44; have not been subjected to sufficient external validation and their use is not systematic&#46; This means that the identification of patients at risk of fracture and therefore those who are candidates for preventive strategies is an unmet need&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bone strength&#44; defined as the ability of the bone to resist fracture&#44; is determined by bone mineral density &#40;measured by bone densitometry&#41;&#44; trabecular architecture and bone tissue quality&#46; The trabecular bone score estimates bone microarchitecture&#44; and low values have been described as an independent predictor of increased fracture risk&#46; Bone microindentation is a minimally invasive technique that measures resistance of the bone to micro-cracks &#40;microscopic separation of mineralized collagen fibers&#41;&#44; and therefore bone tissue biomechanical properties&#46; The superiority over bone densitometry of the correlation between the parameters measured by trabecular bone score and microindentation with the risk of fracture in diverse populations led us to test its feasibility in chronic kidney disease and kidney transplant patients&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La enfermedad &#243;sea asociada a la enfermedad renal cr&#243;nica&#44; y en particular en el paciente trasplantado renal&#44; representa una causa de frecuente morbimortalidad&#44; sobre todo porque predispone a un mayor riesgo de fractura osteopor&#243;tica&#46; Este hecho&#44; bien conocido desde hace d&#233;cadas&#44; no ha estimulado lo suficiente hasta la fecha el desarrollo de una adecuada estrategia diagn&#243;stica&#46; Si dejamos aparte la biopsia &#243;sea&#44; t&#233;cnica invasiva y escasamente utilizada&#44; no disponemos de herramientas capaces de estimar de manera precisa el riesgo de fractura en el paciente renal&#46; La escasa validaci&#243;n externa de t&#233;cnicas aplicadas en la poblaci&#243;n general como la densitometr&#237;a &#243;sea hace que su uso tampoco sea sistem&#225;tico&#46; Por tanto&#44; la identificaci&#243;n de qu&#233; pacientes tienen mayor riesgo de fractura y son susceptibles de intervenci&#243;n preventiva es una necesidad no cubierta&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La resistencia &#243;sea&#44; definida como la capacidad del hueso para resistir la fractura&#44; viene determinada por la cantidad de material mineral &#40;medida como densidad mineral &#243;sea por densitometr&#237;a &#243;sea&#41;&#44; la arquitectura trabecular y la calidad del tejido &#243;seo&#46; El score trabecular &#243;seo estima la microarquitectura &#243;sea y valores bajos se han demostrado como predictores independientes de mayor riesgo de fractura&#46; La microindentaci&#243;n &#243;sea es una t&#233;cnica m&#237;nimamente invasiva capaz de medir la resistencia &#243;sea que el hueso opone a la apertura de <span class="elsevierStyleItalic">micro-cracks</span> &#40;separaci&#243;n microsc&#243;pica de fibras de col&#225;gena mineralizada&#41;&#44; y con ello&#44; las propiedades biomec&#225;nicas del tejido &#243;seo&#46; La buena correlaci&#243;n con el riesgo de fractura de los par&#225;metros medidos con el score trabecular &#243;seo o la microindentaci&#243;n en diversas poblaciones&#44; superior a la propia densitometr&#237;a &#243;sea&#44; nos ha estimulado a desarrollar su potencial aplicaci&#243;n en los pacientes con enfermedad renal cr&#243;nica y trasplantados renales&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez-S&#225;ez MJ&#44; Prieto-Alhambra D&#44; D&#237;ez-P&#233;rez A&#44; Pascual J&#46; Avances en la valoraci&#243;n de la salud &#243;sea en el trasplantado renal&#46; Nefrologia&#46; 2018&#59;38&#58;27&#8211;33&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">BF&#58; bisphosphonates&#59; DD&#58; deceased donor&#59; LD&#58; living donor&#59; EE UU&#58; United States&#59; GC&#58; glucocorticoids&#59; M&#58; male&#59; F&#58; female&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Type of study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Kalker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Accumulated incidence of fracture &#40;100&#37; foot&#41;&#58;<br>10&#37; to 2 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ramsey-Goldman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fractures &#40;foot 42&#46;4&#37;&#41;&#58; 39&#47;1000 people&#47;year<br>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Abbott et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;479&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture &#40;femur 34&#46;8&#37;&#41;&#58;<br>6&#46;90&#47;1000 people&#47;year &#40;M&#41;&#59; 9&#46;93&#47;1000 people&#47;year &#40;F&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ball et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;944&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence hip fracture&#58;<br>3&#46;3&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Conley et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fracture incidence &#40;not vertebral or hip&#41;&#58;<br>No BF 36&#46;7&#47;1000 people&#47;year vs&#46; BF 99&#46;6&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nikkel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;430&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of fractures &#40;foot&#47;ankle 28&#46;2&#37;&#41;&#58;<br>22&#46;5&#37; at 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Rizzari et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">791 &#40;LD&#41;<br>450 &#40;DD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of fractures &#40;early discontinuation of GC&#41;&#58;<br>1&#8211;4&#37; &#40;one year&#41;&#59; 9&#8211;33&#37; &#40;10 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nikkel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&#44;814&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fractures &#40;femur 29&#37;&#41;&#58; 5&#46;8&#47;1&#46;000 people&#47;year &#40;early discontinuation of GC&#41; vs&#46; 8&#47;1&#46;000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naylor et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4821&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of non-vertebral fracture &#40;forearm&#44; humerus&#44; hip&#41;&#58; 5&#46;6&#47;1000 people&#47;year<br>11&#46;1&#47;1000 people&#47;year &#40;F<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>age 50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naylor et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of major fracture&#58;<br>8&#46;1&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Main studies describing the risk of fracture in kidney transplant patients in the EE UU and Canada&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Type of study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De S&#233;vaux et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture &#40;a 50&#37; hip fracture&#41;&#58;<br>34&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Opelz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;509&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of hip fractures&#58;<br>0&#46;85&#37; at 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ferro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;769&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture hospital&#58;<br>9&#46;9&#47;1000 people&#47;year<br>1&#46;54&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hansen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1504&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Any type of fracture&#58;<br>Hazard ratio 1&#46;94 &#91;1&#46;72&#8211;2&#46;18&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dey et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1081&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of symptomatic fracture<br>37&#46;6&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main studies describing the risk of fracture in kidney transplant patients in European population&#46;</p>"
        ]
      ]
      3 => array:6 [
        "identificador" => "tb0005"
        "tipo" => "MULTIMEDIATEXTO"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "texto" => array:1 [
          "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0125" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">Kidney transplant patients have a higher risk of fractures than the general population&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Bone resistance involves various bone properties such as the amount of mineral&#44; architecture and bone tissue quality&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">It is unknown whether techniques used to detect risk of fracture&#44; such as bone densitometry&#44; have the same validity in the transplant population&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Other techniques&#44; such as the bone trabecular score or bone microindentation&#44; are proposed to complement a comprehensive bone evaluation of our patients&#46;</p></li></ul></p></span>"
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Key concepts</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:42 [
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              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "K&#47;DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Kidney Foundation"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14520607"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
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                ]
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "KDIGO clinical practice guideline for the diagnosis&#44; evaluation&#44; prevention&#44; and treatment of Chronic Kidney Disease-Mineral and Bone Disorder &#40;CKD-MBD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Kidney Disease Improving Global Outcomes &#40;KDIGO&#41; CKD-MBD Work Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2009"
                        "volumen" => "76"
                        "numero" => "Suppl&#46; 113"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S130"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recomendaciones de la Sociedad Espa&#241;ola de Nefrolog&#237;a para el manejo de las alteraciones del metabolismo &#243;seo-mineral en los pacientes con enfermedad renal cr&#243;nica &#40;S&#46;E&#46;N&#46;-M&#46;M&#46;&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;V&#46; Torregrosa"
                            1 => "J&#46; Bover"
                            2 => "J&#46; Cannata-And&#237;a"
                            3 => "V&#46; Lorenzo"
                            4 => "A&#46;L&#46;M&#46; de Francisco"
                            5 => "I&#46; Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nefro.2017.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2011"
                        "volumen" => "Suppl&#46; 1"
                        "paginaInicial" => "3"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29248052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone strength&#58; more than just bone density"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;M&#46; Ott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.kint.2015.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2016"
                        "volumen" => "89"
                        "paginaInicial" => "16"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26759040"
                            "web" => "Medline"
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                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
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                      "titulo" => "Persistent hyperparathyroidism is a major risk factor for fractures in the five years after kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Perrin"
                            1 => "S&#46; Cailard"
                            2 => "R&#46;M&#46; Javier"
                            3 => "L&#46; Braun"
                            4 => "F&#46; Heibel"
                            5 => "C&#46; Borni-Duval"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12425"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "2653"
                        "paginaFinal" => "2663"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24034142"
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              "identificador" => "bib0030"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic management of post-kidney transplant hyperparathyroidism"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;B&#46; Copley"
                            1 => "R&#46;P&#46; W&#252;thrich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0012.2010.01287.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2011"
                        "volumen" => "25"
                        "paginaInicial" => "24"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20572835"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone mineral density changes within six months of renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;R&#46; Mikuls"
                            1 => "B&#46;A&#46; Julian"
                            2 => "A&#46; Bartolucci"
                            3 => "K&#46;G&#46; Saag"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000040600.14084.3B"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2003"
                        "volumen" => "75"
                        "paginaInicial" => "49"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12544870"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early rapid loss followed by long-term consolidation characterizes the development of lumbar bone mineral density after kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;M&#46; Brandenburg"
                            1 => "D&#46; Politt"
                            2 => "M&#46; Ketteler"
                            3 => "W&#46;J&#46; Fassbender"
                            4 => "N&#46; Heussen"
                            5 => "R&#46; Westenfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2004"
                        "volumen" => "77"
                        "paginaInicial" => "1566"
                        "paginaFinal" => "1571"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15239623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Foot problems in the diabetic transplant recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Kalker"
                            1 => "J&#46;D&#46; Pirsch"
                            2 => "D&#46; Heisey"
                            3 => "H&#46;W&#46; Sollinger"
                            4 => "F&#46;O&#46; Belzer"
                            5 => "S&#46;J&#46; Knechtle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "1996"
                        "volumen" => "10"
                        "paginaInicial" => "503"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8996770"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of fracture in patients receiving solid organ transplants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Ramsey-Goldman"
                            1 => "J&#46;E&#46; Dunn"
                            2 => "D&#46;D&#46; Dunlop"
                            3 => "F&#46;P&#46; Stuart"
                            4 => "M&#46;M&#46; Abecassis"
                            5 => "D&#46;B&#46; Kaufman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.1999.14.3.456"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "456"
                        "paginaFinal" => "463"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10027911"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hospitalizations for fractures after renal transplantation in the United States"
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                          "autores" => array:6 [
                            0 => "K&#46;C&#46; Abbott"
                            1 => "R&#46;J&#46; Oglesby"
                            2 => "I&#46;O&#46; Hypolite"
                            3 => "A&#46;D&#46; Kirk"
                            4 => "C&#46;W&#46; Ko"
                            5 => "P&#46;G&#46; Welch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Epidemiol"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "450"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11557176"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0060"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of hip fracture among dialysis and renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Ball"
                            1 => "D&#46;L&#46; Gillen"
                            2 => "D&#46; Sherrard"
                            3 => "N&#46;S&#46; Weiss"
                            4 => "S&#46;S&#46; Emerson"
                            5 => "S&#46;L&#46; Seliger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2002"
                        "volumen" => "288"
                        "paginaInicial" => "3014"
                        "paginaFinal" => "3018"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12479766"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022346814006988"
                          "estado" => "S300"
                          "issn" => "00223468"
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                  ]
                ]
              ]
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              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bisphosphonates and bone fractures in long-term kidney transplant recipients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Conley"
                            1 => "B&#46; Muth"
                            2 => "M&#46; Samaniego"
                            3 => "M&#46; Lotfi"
                            4 => "B&#46; Voss"
                            5 => "M&#46; Ambrust"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e318176b40f"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2008"
                        "volumen" => "86"
                        "paginaInicial" => "231"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18645484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0070"
              "etiqueta" => "14"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of fractures after renal transplantation in the United States"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;E&#46; Nikkel"
                            1 => "C&#46;S&#46; Hollenbeak"
                            2 => "E&#46;J&#46; Fox"
                            3 => "T&#46; Uemura"
                            4 => "N&#46; Ghahramani"
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                        ]
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e3181a6bbda"
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                        "tituloSerie" => "Transplantation"
                        "fecha" => "2009"
                        "volumen" => "87"
                        "paginaInicial" => "1846"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19543063"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Rizzari"
                            1 => "T&#46;M&#46; Suszynski"
                            2 => "K&#46;J&#46; Gillingham"
                            3 => "T&#46;B&#46; Dunn"
                            4 => "H&#46;N&#46; Ibrahim"
                            5 => "W&#46;D&#46; Payne"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.2215/CJN.08630811"
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                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "494"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22282482"
                            "web" => "Medline"
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                ]
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              "identificador" => "bib0080"
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                    0 => array:2 [
                      "titulo" => "Reduced fracture risk with early corticosteroid withdrawal after kidney transplant"
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                    0 => array:2 [
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                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2012"
                        "volumen" => "12"
                        "paginaInicial" => "649"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22151430"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0085"
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                    0 => array:2 [
                      "titulo" => "Fracture incidence in adult kidney transplant recipients"
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                            1 => "S&#46;A&#46; Jamal"
                            2 => "G&#46; Zou"
                            3 => "F&#46; McArthur"
                            4 => "N&#46;N&#46; Lam"
                            5 => "W&#46;D&#46; Leslie"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
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                        "volumen" => "100"
                        "paginaInicial" => "167"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26154389"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0090"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Risk factors for fracture in adult kidney transplant recipients"
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                            4 => "N&#46;N&#46; Lam"
                            5 => "E&#46; McArthur"
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                    0 => array:2 [
                      "doi" => "10.5500/wjt.v6.i2.370"
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                        "tituloSerie" => "World J Transplant"
                        "fecha" => "2016"
                        "volumen" => "6"
                        "paginaInicial" => "370"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27358782"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0095"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal vitamin D metabolism and loss of bone mass after renal transplantation"
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                          "autores" => array:5 [
                            0 => "R&#46;G&#46; De S&#233;vaux"
                            1 => "A&#46;J&#46; Hoitsma"
                            2 => "H&#46;J&#46; van Hoof"
                            3 => "F&#46;J&#46; Corstens"
                            4 => "J&#46;F&#46; Wetzels"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000066640"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephron Clin Pract"
                        "fecha" => "2003"
                        "volumen" => "93"
                        "paginaInicial" => "C21"
                        "paginaFinal" => "C28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12411755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of mismatches for HLA-DR with incidence of posttransplant hip fracture in kidney transplant recipients"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Opelz"
                            1 => "B&#46; Dohler"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2011"
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                        "paginaInicial" => "65"
                        "paginaFinal" => "69"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21452411"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fracture risk and mortality post-kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Ferro"
                            1 => "J&#46; Arnold"
                            2 => "D&#46; Bagnall"
                            3 => "D&#46; Ray"
                            4 => "A&#46; Sharif"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ctr.12621"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "1004"
                        "paginaFinal" => "1012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26313646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of fracture in adults on renal replacement therapy&#58; a Danish national cohort study"
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                          "etal" => false
                          "autores" => array:5 [
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                            1 => "J&#46;B&#46; Olesen"
                            2 => "G&#46;H&#46; Gislason"
                            3 => "B&#46; Abrahamsen"
                            4 => "K&#46; Hommel"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfw073"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2016"
                        "volumen" => "31"
                        "paginaInicial" => "1654"
                        "paginaFinal" => "1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27190324"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0115"
              "etiqueta" => "23"
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                0 => array:3 [
                  "comentario" => "&#91;epub ahead of print&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symptomatic fracture risk in the renal replacement therapy population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Dey"
                            1 => "T&#46;E&#46; Farrah"
                            2 => "J&#46;P&#46; Traynor"
                            3 => "E&#46;M&#46; Spalding"
                            4 => "S&#46;E&#46; Robertson"
                            5 => "C&#46;C&#46; Geddes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs152"
                      "Revista" => array:3 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2016"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22773240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High resolution quantitative computed tomography-based assessment of trabecular microstructure and strength estimates by finite-element analysis of the spine&#44; but not DXA&#44; reflects vertebral fracture status in men with glucocorticoid-induced osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Graeff"
                            1 => "F&#46; Marin"
                            2 => "O&#46; Petto"
                            3 => "O&#46; Kayser"
                            4 => "A&#46; Reisinger"
                            5 => "J&#46; Pe&#241;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2012.10.036"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2013"
                        "volumen" => "52"
                        "paginaInicial" => "568"
                        "paginaFinal" => "577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23149277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of collagen organization on the properties of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Garnero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00223-015-9996-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Calcif Tissue Int"
                        "fecha" => "2015"
                        "volumen" => "97"
                        "paginaInicial" => "229"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25894071"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone mineralization density distribution in health and disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Roschger"
                            1 => "E&#46;P&#46; Paschalis"
                            2 => "P&#46; Fratzl"
                            3 => "K&#46; Klaushofer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2007.10.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2008"
                        "volumen" => "42"
                        "paginaInicial" => "456"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18096457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone&#39;s material constituents and their contribution to bone strength in health&#44; disease&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Bala"
                            1 => "E&#46; Seeman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00223-015-9971-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Calcif Tissue Int"
                        "fecha" => "2015"
                        "volumen" => "97"
                        "paginaInicial" => "308"
                        "paginaFinal" => "326"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25712256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "FRAX World Health Organization Fracture Risk Assessment Tool&#46; World Health Organization&#59; 2011&#46; Available from&#58; <a href="http://www.shef.ac.uk/FRAX/index.aspx">http&#58;&#47;&#47;www&#46;shef&#46;ac&#46;uk&#47;FRAX&#47;index&#46;aspx</a> &#91;accessed 10&#46;01&#46;17&#93;&#46;"
                ]
              ]
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            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "FRAX predicts fracture risk in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;L&#46; Naylor"
                            1 => "W&#46;D&#46; Leslie"
                            2 => "A&#46;B&#46; Hodsman"
                            3 => "D&#46;N&#46; Rush"
                            4 => "A&#46;X&#46; Garg"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000438200.84154.1a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2014"
                        "volumen" => "97"
                        "paginaInicial" => "940"
                        "paginaFinal" => "945"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24503761"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low bone mineral density and fractures in stages 3-5 CKD&#58; an updated systematic review and meta-analysis"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Bucur"
                            1 => "D&#46;D&#46; Panjwani"
                            2 => "L&#46; Turner"
                            3 => "T&#46; Rader"
                            4 => "S&#46;L&#46; Wes"
                            5 => "S&#46;A&#46; Jamal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Osteopor Int"
                        "fecha" => "2015"
                        "volumen" => "26"
                        "paginaInicial" => "449"
                        "paginaFinal" => "458"
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trabecular bone score&#58; a noninvasive analytical method based upon the DXA image"
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                          "etal" => true
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                            4 => "O&#46; Lesnyak"
                            5 => "N&#46; Binkley"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.2176"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "518"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24443324"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone mass and microarchitecture in CKD patients with fracture"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;L&#46; Nickolas"
                            1 => "E&#46; Stein"
                            2 => "A&#46; Cohen"
                            3 => "V&#46; Thomas"
                            4 => "R&#46;B&#46; Staron"
                            5 => "D&#46;J&#46; McMahon"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2009121208"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2010"
                        "volumen" => "21"
                        "paginaInicial" => "1371"
                        "paginaFinal" => "1380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20395370"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0165"
              "etiqueta" => "33"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Kidney transplantation with early corticosteroid withdrawal&#58; paradoxical effects at the central and peripheral skeleton"
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                            1 => "L&#46;E&#46; Nikkel"
                            2 => "K&#46;K&#46; Nishiyama"
                            3 => "E&#46; Dworakowski"
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                            5 => "C&#46; Zhang"
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                        "tituloSerie" => "J Am Soc Nephrol"
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                        "paginaFinal" => "1341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24511131"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0170"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Osteoporosis and impaired trabecular bone score in hemodialysis patients"
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                    0 => array:2 [
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                        "tituloSerie" => "Kidney Blood Press Res"
                        "fecha" => "2016"
                        "volumen" => "41"
                        "paginaInicial" => "345"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27333273"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trabecular bone score in kidney transplant recipients"
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                            4 => "D&#46;N&#46; Rush"
                            5 => "A&#46;B&#46; Hodsman"
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                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2016"
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                        "paginaInicial" => "1115"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microindentation for in vivo measurement of bone tissue mechanical properties in humans"
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                          "etal" => true
                          "autores" => array:6 [
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                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "1877"
                        "paginaFinal" => "1885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20200991"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
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              "identificador" => "bib0185"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "In vivo assessment of bone quality in postmenopausal women with type 2 diabetes"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;N&#46; Farr"
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                            2 => "S&#46; Amin"
                            3 => "L&#46;J&#46; Melton 3r"
                            4 => "L&#46;K&#46; McCready"
                            5 => "S&#46; Khosla"
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "787"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24123088"
                            "web" => "Medline"
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              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone material strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of bone mineral density"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "N&#46;A&#46; Hamdy"
                            2 => "S&#46;E&#46; Papapoulos"
                            3 => "N&#46;M&#46; Appelman-Dijkstra"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2014-4346"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2015"
                        "volumen" => "100"
                        "paginaInicial" => "2039"
                        "paginaFinal" => "2045"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25768670"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone tissue properties measurement by reference point indentation in glucocorticoid-induced osteoporosis"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mellibovsky"
                            1 => "D&#46; Prieto-Alhambra"
                            2 => "F&#46; Mellibovsky"
                            3 => "R&#46; G&#252;erri-Fern&#225;ndez"
                            4 => "X&#46; Nogu&#233;s"
                            5 => "C&#46; Randall"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.2497"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2015"
                        "volumen" => "30"
                        "paginaInicial" => "1651"
                        "paginaFinal" => "1656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25736591"
                            "web" => "Medline"
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                ]
              ]
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              "identificador" => "bib0200"
              "etiqueta" => "40"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone material strength is associated with areal BMD but not with prevalent fractures in older women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Rud&#228;ng"
                            1 => "M&#46; Zoulakis"
                            2 => "D&#46; Sundh"
                            3 => "H&#46; Brisby"
                            4 => "A&#46; D&#237;ez-P&#233;rez"
                            5 => "L&#46; Johansson"
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                    ]
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                  "host" => array:1 [
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                      "doi" => "10.1007/s00198-015-3419-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "1585"
                        "paginaFinal" => "1592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26630975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Brief review
Advances in the evaluation of bone health in kidney transplant patients
Avances en la valoración de la salud ósea en el trasplantado renal
María José Pérez-Sáeza,b,c, Daniel Prieto-Alhambrab,d,e, Adolfo Díez-Pérezb,e,f, Julio Pascuala,b,c,
Corresponding author
julpascual@gmail.com

Corresponding author.
a Servicio de Nefrología, Hospital del Mar, Barcelona, Spain
b Institut Mar d’Investigacions Mediques, Barcelona, Spain
c REDinREN, Instituto Carlos III, Madrid, Spain
d Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom
e CIBERFES, Instituto Carlos III, Madrid, Spain
f Servicio de Medicina Interna, Hospital del Mar, Universidad Autonóma de Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Achieving bone health in the population with chronic kidney disease &#40;CKD&#41; is a unresolved issue&#46; The guidelines suggest that bone health should be evaluated using spine Z-ray for screening of asymptomatic vertebral fractures or bone densitometry &#40;dual X-ray absorptiometry&#44; DXA&#41; to determine of bone mineral density &#40;BMD&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> However&#44; BMD is not the only feature that makes the bone able to absorb the energy of an impact and prevent a bone fracture&#46; Other properties such as bone microarchitecture or the quality of bone tissue are determinants of bone resistance to fracture&#46; Furthermore&#44; although there is a good correlation between BMD and the risk of fracture in the general population&#44; the validation of DXA as a reference diagnostic technique in the renal population has not been fully established&#44; so it is not performed as a routine in clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We have reviewed the various diagnostic strategies to evaluate bone health in renal patients&#44; with special interest in the kidney transplant &#40;KT&#41; recipient&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Justification&#58; bone disease and fractures after kidney transplantation</span><p id="par0015" class="elsevierStylePara elsevierViewall">The bone mineral disease in CKD patients is characterized by abnormalities in bone turnover&#44; mineralization and bone density&#44; which cause bone fragility and an increased risk of fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the transplant patient&#44; bone disease has its own peculiarities that are associated to the recovery of renal function&#44; persistent hyperparathyroidism<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and immunosuppressive treatment which is inherent in the transplant process&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The main alteration in bone remodeling after renal transplantation is the reduction in bone formation and mineralization&#44; with a persistent predominance of resorption&#46; In fact&#44; during the first 6 months after transplantation&#44; there is a rapid decrease in BMD&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> which is subsequently attenuated&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> most likely related to the decrease in the dose of steroids&#46; As a result&#44; a high risk of fracture has been described in patients after KT &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;23</span></a> which&#44; initially&#44; is even higher than that in dialysis patients&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In addition&#44; it has been proven that this increase in risk persists in the late post-transplant period&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">State of the art&#58; diagnosis of bone disease in the kidney transplant patient</span><p id="par0025" class="elsevierStylePara elsevierViewall">Evaluation of bone health in the renal patient is key to estimate the risk of fracture&#46; Laboratory measurements such as bone remodeling markers&#44; or invasive procedures such as bone biopsy are available for assessment of bone health&#44; but it is not clear which diagnostic tests best predict the risk of fracture&#46; Unlike in the general population&#44; risk scales or DXA have a much more limited predictive power&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To establish the accurate diagnosis of bone disease&#44; it is necessary to understand the different properties contributing bone resistance&#46; Bone quantity is determined by BMD and expressed as grams of mineral per bone area &#40;or volume if measured by computed tomography&#41;&#46; In a given individual&#44; it is determined by the maximum bone mass achieved and the rate of bone loss&#46; Other aspects of bone quality also contribute to the bone mechanical strength&#58; the spatial distribution of bone at the macroscopic &#40;geometry&#41; and microscopic &#40;microarchitecture&#41; level&#44; and the composition of the bone tissue itself&#46; The spatial distribution of bone can be determined by different imaging techniques&#44; from simple radiography to high-resolution tomography or magnetic resonance&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> The higher the image resolution&#44; the better the estimation of microscopic bone structure&#46; In addition&#44; the physical&#44; chemical and biological components of the bone tissue are equally relevant for bone strength and mechanical performance of the bone&#44; including characteristics of collagen&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> degree and homogenization of mineralization<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> and non-collagenous proteins&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">There are different techniques that provide information on the different bone properties that help to make the diagnosis of bone disease after kidney transplantation&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Bone X-ray can identify lesions that are characteristic of renal osteodystrophy&#44; but these changes occur very late&#46; Its main diagnostic value is the ability to detect asymptomatic vertebral fractures&#44; a fact that predisposes to suffer a osteoporotic fracture of greater magnitude&#46; This helps to select a population with a higher risk of fracture&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Among CKD patients it is not common to use the Fracture Risk Assessment Tool &#40;FRAX&#41;&#44; which estimates the probability at 10 years of major osteoporotic fracture &#40;clinical vertebral&#44; hip&#44; forearm and humerus&#41; applying an algorithm based on age&#44; gender and clinical factors &#40;with or without BMD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Therefore the predictive capacity of FRAX in this population is unknown&#46; In a recent study&#44; the FRAX score was applied to KT patients with a mean of 1&#46;1 years after transplantation&#46; Most of them were categorized as having a &#8220;low risk&#8221; of fracture at 10 years&#44; showing a modest predictive power of the score since 4&#46;6&#37; of patients had a fracture at 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">DXA is currently the standard method to determine BMD in the general population and is used for screening for osteoporosis in CKD patients&#46; It provides information about the total amount of mineral in the scanned bone area &#8211; usually the neck of the femur and the vertebrae &#8211; although it does not distinguish changes in bone turnover or characteristics of the bone matrix&#46; In patients with CKD&#44; tissue or vascular calcifications may interfere with bone measurements and give falsely elevated values&#46; Likewise&#44; post-transplant calcium mobilization could lower BMD values&#44; without actually changing the bone mineral content&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In patients with CKD stages 3&#8211;5D&#44; it is not recommended the routine performance of DXA for determination of BMD&#44; due to its low predictive power of fractures and its inability to diagnose the type of renal osteodystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In CKD patients&#44; lumbar or hip BMD can be misleading and may lead to inadequate administration of antiresorptive drugs&#46; The best location for BMD measurement is the distal radius&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Even with these limitations&#44; renal patients with lower BMD at the lumbar and femoral neck have the highest incidence of fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">However&#44; DXA cannot detect other bone properties of bone strength that are relevant to predict the risk of fracture&#44; such as bone trabecular microarchitecture<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> or other mechanical properties such as elasticity&#44; trabecular spatial arrangement or the quality of the collagen matrix that are&#44; also determinants of bone resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The bone biopsy the gold-standard diagnostic test to establish the patients bone health&#44; but it is invasive&#44; laborious and expensive&#44; consequently it is used very infrequently in clinical practice&#46; Thus given that DXA is not able to fully detect bone resistance to fractures&#44; additional diagnostic tests are needed to establish the risk of fracture&#46; Three diagnostic tests have emerged in recent years&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall">High resolution peripheral quantitative computer tomography&#44; used in patients with CKD&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> or KT<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> measures the volumetric density of the cortical and trabecular region separately&#44; and has a resolution that allows analyzing the bone microarchitecture&#46; However&#44; it is expensive and so far not very accessible in usual practice&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">The trabecular bone score &#40;TBS&#41;&#44; analyzes the trabecular bone microarchitecture in the lumbar spine using specific software in images obtained with DXA&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Abnormal trabecular microarchitecture at the vertebral level has been associated with an increased risk of fracture&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Lower TBS values have been described in the hemodialysis population<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> and in Kidney transplant patients &#8211; in the early post-transplant &#8211; with respect to the general population&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> with the risk of fracture that this entails&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">Bone microindentation is a technique capable of directly measuring mechanical properties of bone at the tissue level&#46; This was first described in a clinical series in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> It is based on microscopic indentation&#44; which measures the resistance of the cortical bone to the opening of microscopic fractures or micro-fractures&#44; a phenomenon intimately linked to the beginning of the solution of continuity in the bone that gives rise to the fracture&#46; To date&#44; 2 main techniques have been developed&#58; cyclical microindentation and impact microindentation&#46; Both are included in the generic term of reference point indentation and are based on the principle that the deeper a needle penetrates the anterior face of the tibia&#44; the less resistant the bone tissue will be to a mechanic impact&#46; The cyclic microindentation was used in the first studies including patients<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#59; the study by impact microindentation&#44; simplifies the method of measurement<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#8211;39</span></a> and makes it preferable for clinical use&#46; The procedure is simple&#46; It is performed on the anterior face of the tibia with an indenting handheld device&#44; Osteoprobe<span class="elsevierStyleSup">&#174;</span> &#40;Active Life Scientific&#44; Santa Barbara&#44; CA&#44; USA&#41;&#46; After administering local anesthesia at the puncture site&#44; a preload of 10<span class="elsevierStyleHsp" style=""></span>N of force followed by an indentation of 30<span class="elsevierStyleHsp" style=""></span>N using a conical needle of 4<span class="elsevierStyleHsp" style=""></span>&#956;m is applied&#46; The mean of 8 indentation values is transformed by a computerized algorithm&#46; Then&#44; 5 calibration indentations are made in a block of polymethyl methacrylate&#46; The ratio between the value provided by the bone and by the block provides the final parameter&#44; the bone mineral resistance index&#44; which is expressed in absolute units&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">The propensity to bone fractures is the result of the deterioration of BMD&#44; microarchitecture and bone tissue properties&#44; which can occur individually or in combination and in different proportions depending on each pathophysiological situation&#46; Therefore&#44; for a complete calculation we must contemplate the 3 components&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Impact microindentation has been applied in the study of other patient populations in which the risk of fracture can only be partially established with DXA&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#8211;39</span></a> There are situations&#44; such as in elderly women&#44; where microindentation does not seem to add value to the prediction of risk of fracture&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> perhaps because it is a population in which BMD and microarchitecture&#44; are already very deteriorated playing a predominant role in the loss of bone strength&#46; By contrast&#44; in women with type 2 diabetes&#44; where both BMD and trabecular microarchitecture are preserved while the risk of fracture is clearly high&#44; the bone mineral resistance index was the most abnormal component of bone strength&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Therefore&#44; microindentation can be a complement to the existing bone analysis methods&#44; particularly in populations where BMD does not satisfactorily explain the propensity to fracture&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The best method to estimate the risk of fracture in a patient with CKD is unknown&#46; An improvement of the diagnostic methods to determine the risk of fracture is crucial as a first step for the indication of any preventive treatment &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Bone health in the long-term kidney transplant patient</span><p id="par0100" class="elsevierStylePara elsevierViewall">In our group&#44; we aimed to analyze the bone health of a cohort of long term kidney transplant patients&#44; taking into account different bone properties that contribute to bone strength&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> So we performed a case&#8211;control study&#44; in KT patients of more than 10 years of follow up and healthy controls without kidney disease or any relevant factor that may affect bone health&#46; The transplant patients had a lower BMD than healthy controls&#46; However&#44; the trabecular microarchitecture estimated by TBS and the bone tissue quality measured by microindentation were comparable in both groups&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In renal transplant patients&#44; the TBS is lower than in the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> However&#44; this study analyzed TBS in the early post-transplant&#44; this is in contrast with our KT patients of more than 10 years of evolution that showed values of TBS similar to controls suggesting a recuperation of bone health after years post transplantation&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Additionally&#44; we performed bone microindentation tests for the first time in subjects with kidney disease and our patients presented bone strength values similar to those of healthy controls&#46; This indicates that the bone affectation in this transplanted population of long evolution is no longer very relevant since values of bone quality of these receptors are similar to the general population&#46; In addition&#44; these results are in agreement with studies showing that bone changes in the post-transplant period are temporary and revert with a fast reduction or suspension of glucocorticoids&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;42</span></a> In this regard&#44; it is noteworthy that 80&#37; of our cohort did not have glucocorticoids as a base immunosuppressive treatment at the time of the study&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Therefore&#44; in general terms&#44; the results obtained showed bone normalization in the late post-transplant&#44; despite the fact that the BMD values were lower than those of the healthy controls&#46; As far as we know&#44; this is the first study that assesses bone health in KT&#44; taking into account all its different components&#58; bone quantity&#44; trabecular microstructure and bone tissue quality&#46; Therefore this is the first study performed in renal patients which includes measurement of bone quality by means of microindentation which evaluates mechanical properties of the bone providing additional information about bone resistance using a method that is simple and clinically viable&#46; However&#44; longitudinal studies with an appropriate number of patients will be necessary to determine the value of bone microindentation to predict the risk of fracture in this population&#44; and to define the value of microindentation to monitor bone mineral resistance index in response to different therapeutic strategies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="par0120" class="elsevierStylePara elsevierViewall">The predisposition to fracture is determined by bone resistance which results from several bone properties that complement each other and can be evaluated separately with different diagnostic tests&#46; To estimate risk fracture adequately&#44; both bone quantity and quality must be evaluated&#46; Among renal patients&#44; those with kidney transplant require complete evaluation of bone characteristics so optimal preventive intervention is applied&#46; Results from TBS and bone microindentation have been associated with an increased risk of fractures in other populations&#44; although additional prospective studies including large number of patients and longer follow-up will confirm the clinical usefulness of these techniques and their ability to predict bone fractures&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">The DPA institution has received funds for research scholarships from AMGEN and BIOIBERICA&#46; ADP is a shareholder of Active Life Scientific&#46; The rest of the authors declare no conflict of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bone disease related to chronic kidney disease and&#44; particularly&#44; to kidney transplant patients is a common cause or morbidity and mortality&#44; especially due to a higher risk of osteoporotic fractures&#46; Despite the fact that this has been known for decades&#44; to date&#44; an appropriate diagnostic strategy has yet to be established&#46; Apart from bone biopsy&#44; which is invasive and scarcely used&#44; no other technique is available to accurately establish the risk of fracture in kidney patients&#46; Techniques applied to the general population&#44; such as bone densitometry&#44; have not been subjected to sufficient external validation and their use is not systematic&#46; This means that the identification of patients at risk of fracture and therefore those who are candidates for preventive strategies is an unmet need&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bone strength&#44; defined as the ability of the bone to resist fracture&#44; is determined by bone mineral density &#40;measured by bone densitometry&#41;&#44; trabecular architecture and bone tissue quality&#46; The trabecular bone score estimates bone microarchitecture&#44; and low values have been described as an independent predictor of increased fracture risk&#46; Bone microindentation is a minimally invasive technique that measures resistance of the bone to micro-cracks &#40;microscopic separation of mineralized collagen fibers&#41;&#44; and therefore bone tissue biomechanical properties&#46; The superiority over bone densitometry of the correlation between the parameters measured by trabecular bone score and microindentation with the risk of fracture in diverse populations led us to test its feasibility in chronic kidney disease and kidney transplant patients&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La enfermedad &#243;sea asociada a la enfermedad renal cr&#243;nica&#44; y en particular en el paciente trasplantado renal&#44; representa una causa de frecuente morbimortalidad&#44; sobre todo porque predispone a un mayor riesgo de fractura osteopor&#243;tica&#46; Este hecho&#44; bien conocido desde hace d&#233;cadas&#44; no ha estimulado lo suficiente hasta la fecha el desarrollo de una adecuada estrategia diagn&#243;stica&#46; Si dejamos aparte la biopsia &#243;sea&#44; t&#233;cnica invasiva y escasamente utilizada&#44; no disponemos de herramientas capaces de estimar de manera precisa el riesgo de fractura en el paciente renal&#46; La escasa validaci&#243;n externa de t&#233;cnicas aplicadas en la poblaci&#243;n general como la densitometr&#237;a &#243;sea hace que su uso tampoco sea sistem&#225;tico&#46; Por tanto&#44; la identificaci&#243;n de qu&#233; pacientes tienen mayor riesgo de fractura y son susceptibles de intervenci&#243;n preventiva es una necesidad no cubierta&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La resistencia &#243;sea&#44; definida como la capacidad del hueso para resistir la fractura&#44; viene determinada por la cantidad de material mineral &#40;medida como densidad mineral &#243;sea por densitometr&#237;a &#243;sea&#41;&#44; la arquitectura trabecular y la calidad del tejido &#243;seo&#46; El score trabecular &#243;seo estima la microarquitectura &#243;sea y valores bajos se han demostrado como predictores independientes de mayor riesgo de fractura&#46; La microindentaci&#243;n &#243;sea es una t&#233;cnica m&#237;nimamente invasiva capaz de medir la resistencia &#243;sea que el hueso opone a la apertura de <span class="elsevierStyleItalic">micro-cracks</span> &#40;separaci&#243;n microsc&#243;pica de fibras de col&#225;gena mineralizada&#41;&#44; y con ello&#44; las propiedades biomec&#225;nicas del tejido &#243;seo&#46; La buena correlaci&#243;n con el riesgo de fractura de los par&#225;metros medidos con el score trabecular &#243;seo o la microindentaci&#243;n en diversas poblaciones&#44; superior a la propia densitometr&#237;a &#243;sea&#44; nos ha estimulado a desarrollar su potencial aplicaci&#243;n en los pacientes con enfermedad renal cr&#243;nica y trasplantados renales&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; P&#233;rez-S&#225;ez MJ&#44; Prieto-Alhambra D&#44; D&#237;ez-P&#233;rez A&#44; Pascual J&#46; Avances en la valoraci&#243;n de la salud &#243;sea en el trasplantado renal&#46; Nefrologia&#46; 2018&#59;38&#58;27&#8211;33&#46;</p>"
      ]
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Comparison between the different diagnostic tests to estimate bone health&#46;</p>"
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">BF&#58; bisphosphonates&#59; DD&#58; deceased donor&#59; LD&#58; living donor&#59; EE UU&#58; United States&#59; GC&#58; glucocorticoids&#59; M&#58; male&#59; F&#58; female&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Type of study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Kalker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">214&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Accumulated incidence of fracture &#40;100&#37; foot&#41;&#58;<br>10&#37; to 2 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ramsey-Goldman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fractures &#40;foot 42&#46;4&#37;&#41;&#58; 39&#47;1000 people&#47;year<br>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Abbott et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;479&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture &#40;femur 34&#46;8&#37;&#41;&#58;<br>6&#46;90&#47;1000 people&#47;year &#40;M&#41;&#59; 9&#46;93&#47;1000 people&#47;year &#40;F&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ball et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#46;944&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence hip fracture&#58;<br>3&#46;3&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Conley et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fracture incidence &#40;not vertebral or hip&#41;&#58;<br>No BF 36&#46;7&#47;1000 people&#47;year vs&#46; BF 99&#46;6&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nikkel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;430&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of fractures &#40;foot&#47;ankle 28&#46;2&#37;&#41;&#58;<br>22&#46;5&#37; at 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Rizzari et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">791 &#40;LD&#41;<br>450 &#40;DD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of fractures &#40;early discontinuation of GC&#41;&#58;<br>1&#8211;4&#37; &#40;one year&#41;&#59; 9&#8211;33&#37; &#40;10 years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nikkel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&#44;814&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fractures &#40;femur 29&#37;&#41;&#58; 5&#46;8&#47;1&#46;000 people&#47;year &#40;early discontinuation of GC&#41; vs&#46; 8&#47;1&#46;000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naylor et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4821&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of non-vertebral fracture &#40;forearm&#44; humerus&#44; hip&#41;&#58; 5&#46;6&#47;1000 people&#47;year<br>11&#46;1&#47;1000 people&#47;year &#40;F<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>age 50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Naylor et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2723&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of major fracture&#58;<br>8&#46;1&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Main studies describing the risk of fracture in kidney transplant patients in the EE UU and Canada&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Type of study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De S&#233;vaux et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture &#40;a 50&#37; hip fracture&#41;&#58;<br>34&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Opelz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;509&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cumulative incidence of hip fractures&#58;<br>0&#46;85&#37; at 5 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ferro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;769&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of fracture hospital&#58;<br>9&#46;9&#47;1000 people&#47;year<br>1&#46;54&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hansen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1504&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Any type of fracture&#58;<br>Hazard ratio 1&#46;94 &#91;1&#46;72&#8211;2&#46;18&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dey et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Registry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1081&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Incidence of symptomatic fracture<br>37&#46;6&#47;1000 people&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Main studies describing the risk of fracture in kidney transplant patients in European population&#46;</p>"
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      3 => array:6 [
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        "tipo" => "MULTIMEDIATEXTO"
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          "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0125" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0130" class="elsevierStylePara elsevierViewall">Kidney transplant patients have a higher risk of fractures than the general population&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">Bone resistance involves various bone properties such as the amount of mineral&#44; architecture and bone tissue quality&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">It is unknown whether techniques used to detect risk of fracture&#44; such as bone densitometry&#44; have the same validity in the transplant population&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Other techniques&#44; such as the bone trabecular score or bone microindentation&#44; are proposed to complement a comprehensive bone evaluation of our patients&#46;</p></li></ul></p></span>"
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Key concepts</p>"
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                      "titulo" => "K&#47;DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease"
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                          "colaboracion" => "National Kidney Foundation"
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                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
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                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S11"
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                    0 => array:2 [
                      "titulo" => "KDIGO clinical practice guideline for the diagnosis&#44; evaluation&#44; prevention&#44; and treatment of Chronic Kidney Disease-Mineral and Bone Disorder &#40;CKD-MBD&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Kidney Disease Improving Global Outcomes &#40;KDIGO&#41; CKD-MBD Work Group"
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                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2009"
                        "volumen" => "76"
                        "numero" => "Suppl&#46; 113"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S130"
                      ]
                    ]
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                    0 => array:2 [
                      "titulo" => "Recomendaciones de la Sociedad Espa&#241;ola de Nefrolog&#237;a para el manejo de las alteraciones del metabolismo &#243;seo-mineral en los pacientes con enfermedad renal cr&#243;nica &#40;S&#46;E&#46;N&#46;-M&#46;M&#46;&#41;"
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                          "autores" => array:6 [
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                            2 => "J&#46; Cannata-And&#237;a"
                            3 => "V&#46; Lorenzo"
                            4 => "A&#46;L&#46;M&#46; de Francisco"
                            5 => "I&#46; Mart&#237;nez"
                          ]
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                      "titulo" => "Bone strength&#58; more than just bone density"
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                          "autores" => array:1 [
                            0 => "S&#46;M&#46; Ott"
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                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2016"
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                        "paginaFinal" => "19"
                        "link" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Persistent hyperparathyroidism is a major risk factor for fractures in the five years after kidney transplantation"
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                            3 => "L&#46; Braun"
                            4 => "F&#46; Heibel"
                            5 => "C&#46; Borni-Duval"
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                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "2653"
                        "paginaFinal" => "2663"
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                      "titulo" => "Therapeutic management of post-kidney transplant hyperparathyroidism"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;B&#46; Copley"
                            1 => "R&#46;P&#46; W&#252;thrich"
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                      ]
                    ]
                  ]
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                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2011"
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                        "paginaFinal" => "39"
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                      "titulo" => "Bone mineral density changes within six months of renal transplantation"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;R&#46; Mikuls"
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                            3 => "K&#46;G&#46; Saag"
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                        "tituloSerie" => "Transplantation"
                        "fecha" => "2003"
                        "volumen" => "75"
                        "paginaInicial" => "49"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12544870"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0040"
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                    0 => array:2 [
                      "titulo" => "Early rapid loss followed by long-term consolidation characterizes the development of lumbar bone mineral density after kidney transplantation"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "M&#46; Ketteler"
                            3 => "W&#46;J&#46; Fassbender"
                            4 => "N&#46; Heussen"
                            5 => "R&#46; Westenfeld"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "1566"
                        "paginaFinal" => "1571"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15239623"
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                      "titulo" => "Foot problems in the diabetic transplant recipient"
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                            0 => "A&#46;J&#46; Kalker"
                            1 => "J&#46;D&#46; Pirsch"
                            2 => "D&#46; Heisey"
                            3 => "H&#46;W&#46; Sollinger"
                            4 => "F&#46;O&#46; Belzer"
                            5 => "S&#46;J&#46; Knechtle"
                          ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "1996"
                        "volumen" => "10"
                        "paginaInicial" => "503"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8996770"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0050"
              "etiqueta" => "10"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of fracture in patients receiving solid organ transplants"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Ramsey-Goldman"
                            1 => "J&#46;E&#46; Dunn"
                            2 => "D&#46;D&#46; Dunlop"
                            3 => "F&#46;P&#46; Stuart"
                            4 => "M&#46;M&#46; Abecassis"
                            5 => "D&#46;B&#46; Kaufman"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.1999.14.3.456"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "456"
                        "paginaFinal" => "463"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10027911"
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                ]
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              "identificador" => "bib0055"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hospitalizations for fractures after renal transplantation in the United States"
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                          ]
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                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Epidemiol"
                        "fecha" => "2001"
                        "volumen" => "11"
                        "paginaInicial" => "450"
                        "paginaFinal" => "457"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11557176"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Risk of hip fracture among dialysis and renal transplant recipients"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Ball"
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                            3 => "N&#46;S&#46; Weiss"
                            4 => "S&#46;S&#46; Emerson"
                            5 => "S&#46;L&#46; Seliger"
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                        "paginaFinal" => "3018"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12479766"
                            "web" => "Medline"
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                          "issn" => "00223468"
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              "identificador" => "bib0065"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bisphosphonates and bone fractures in long-term kidney transplant recipients"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "B&#46; Muth"
                            2 => "M&#46; Samaniego"
                            3 => "M&#46; Lotfi"
                            4 => "B&#46; Voss"
                            5 => "M&#46; Ambrust"
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                        "paginaInicial" => "231"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18645484"
                            "web" => "Medline"
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                      "titulo" => "Risk of fractures after renal transplantation in the United States"
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                          "autores" => array:5 [
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                            "web" => "Medline"
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                      "titulo" => "Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation"
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                        "tituloSerie" => "Clin J Am Soc Nephrol"
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                        "paginaFinal" => "503"
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                        "paginaInicial" => "649"
                        "paginaFinal" => "659"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Fracture incidence in adult kidney transplant recipients"
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                            4 => "N&#46;N&#46; Lam"
                            5 => "W&#46;D&#46; Leslie"
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                        "paginaInicial" => "167"
                        "paginaFinal" => "175"
                        "link" => array:1 [
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                ]
              ]
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                      "titulo" => "Risk factors for fracture in adult kidney transplant recipients"
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                      "doi" => "10.5500/wjt.v6.i2.370"
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                        "tituloSerie" => "World J Transplant"
                        "fecha" => "2016"
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                        "paginaInicial" => "370"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27358782"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0095"
              "etiqueta" => "19"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal vitamin D metabolism and loss of bone mass after renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;G&#46; De S&#233;vaux"
                            1 => "A&#46;J&#46; Hoitsma"
                            2 => "H&#46;J&#46; van Hoof"
                            3 => "F&#46;J&#46; Corstens"
                            4 => "J&#46;F&#46; Wetzels"
                          ]
                        ]
                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000066640"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephron Clin Pract"
                        "fecha" => "2003"
                        "volumen" => "93"
                        "paginaInicial" => "C21"
                        "paginaFinal" => "C28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12411755"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0100"
              "etiqueta" => "20"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of mismatches for HLA-DR with incidence of posttransplant hip fracture in kidney transplant recipients"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Opelz"
                            1 => "B&#46; Dohler"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2011"
                        "volumen" => "91"
                        "paginaInicial" => "65"
                        "paginaFinal" => "69"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21452411"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fracture risk and mortality post-kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Ferro"
                            1 => "J&#46; Arnold"
                            2 => "D&#46; Bagnall"
                            3 => "D&#46; Ray"
                            4 => "A&#46; Sharif"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ctr.12621"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Transplant"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "1004"
                        "paginaFinal" => "1012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26313646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of fracture in adults on renal replacement therapy&#58; a Danish national cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Hansen"
                            1 => "J&#46;B&#46; Olesen"
                            2 => "G&#46;H&#46; Gislason"
                            3 => "B&#46; Abrahamsen"
                            4 => "K&#46; Hommel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfw073"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2016"
                        "volumen" => "31"
                        "paginaInicial" => "1654"
                        "paginaFinal" => "1662"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27190324"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;epub ahead of print&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symptomatic fracture risk in the renal replacement therapy population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Dey"
                            1 => "T&#46;E&#46; Farrah"
                            2 => "J&#46;P&#46; Traynor"
                            3 => "E&#46;M&#46; Spalding"
                            4 => "S&#46;E&#46; Robertson"
                            5 => "C&#46;C&#46; Geddes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs152"
                      "Revista" => array:3 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2016"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22773240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High resolution quantitative computed tomography-based assessment of trabecular microstructure and strength estimates by finite-element analysis of the spine&#44; but not DXA&#44; reflects vertebral fracture status in men with glucocorticoid-induced osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Graeff"
                            1 => "F&#46; Marin"
                            2 => "O&#46; Petto"
                            3 => "O&#46; Kayser"
                            4 => "A&#46; Reisinger"
                            5 => "J&#46; Pe&#241;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2012.10.036"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2013"
                        "volumen" => "52"
                        "paginaInicial" => "568"
                        "paginaFinal" => "577"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23149277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of collagen organization on the properties of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Garnero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00223-015-9996-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Calcif Tissue Int"
                        "fecha" => "2015"
                        "volumen" => "97"
                        "paginaInicial" => "229"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25894071"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone mineralization density distribution in health and disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Roschger"
                            1 => "E&#46;P&#46; Paschalis"
                            2 => "P&#46; Fratzl"
                            3 => "K&#46; Klaushofer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2007.10.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2008"
                        "volumen" => "42"
                        "paginaInicial" => "456"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18096457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone&#39;s material constituents and their contribution to bone strength in health&#44; disease&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Y&#46; Bala"
                            1 => "E&#46; Seeman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00223-015-9971-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Calcif Tissue Int"
                        "fecha" => "2015"
                        "volumen" => "97"
                        "paginaInicial" => "308"
                        "paginaFinal" => "326"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25712256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "FRAX World Health Organization Fracture Risk Assessment Tool&#46; World Health Organization&#59; 2011&#46; Available from&#58; <a href="http://www.shef.ac.uk/FRAX/index.aspx">http&#58;&#47;&#47;www&#46;shef&#46;ac&#46;uk&#47;FRAX&#47;index&#46;aspx</a> &#91;accessed 10&#46;01&#46;17&#93;&#46;"
                ]
              ]
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            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "FRAX predicts fracture risk in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;L&#46; Naylor"
                            1 => "W&#46;D&#46; Leslie"
                            2 => "A&#46;B&#46; Hodsman"
                            3 => "D&#46;N&#46; Rush"
                            4 => "A&#46;X&#46; Garg"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000438200.84154.1a"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2014"
                        "volumen" => "97"
                        "paginaInicial" => "940"
                        "paginaFinal" => "945"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24503761"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low bone mineral density and fractures in stages 3-5 CKD&#58; an updated systematic review and meta-analysis"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Bucur"
                            1 => "D&#46;D&#46; Panjwani"
                            2 => "L&#46; Turner"
                            3 => "T&#46; Rader"
                            4 => "S&#46;L&#46; Wes"
                            5 => "S&#46;A&#46; Jamal"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Osteopor Int"
                        "fecha" => "2015"
                        "volumen" => "26"
                        "paginaInicial" => "449"
                        "paginaFinal" => "458"
                      ]
                    ]
                  ]
                ]
              ]
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            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Trabecular bone score&#58; a noninvasive analytical method based upon the DXA image"
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                          "etal" => true
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                            4 => "O&#46; Lesnyak"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.2176"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "518"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24443324"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone mass and microarchitecture in CKD patients with fracture"
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                            4 => "R&#46;B&#46; Staron"
                            5 => "D&#46;J&#46; McMahon"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2009121208"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2010"
                        "volumen" => "21"
                        "paginaInicial" => "1371"
                        "paginaFinal" => "1380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20395370"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Kidney transplantation with early corticosteroid withdrawal&#58; paradoxical effects at the central and peripheral skeleton"
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                        "tituloSerie" => "J Am Soc Nephrol"
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                        "paginaInicial" => "1331"
                        "paginaFinal" => "1341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24511131"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteoporosis and impaired trabecular bone score in hemodialysis patients"
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                          "etal" => true
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                            0 => "L&#46; Burnerov&#225;"
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                            4 => "J&#46; Poto&#232;kov&#225;"
                            5 => "P&#46; Kasalick&#253;"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1159/000443439"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Blood Press Res"
                        "fecha" => "2016"
                        "volumen" => "41"
                        "paginaInicial" => "345"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27333273"
                            "web" => "Medline"
                          ]
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                  ]
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              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trabecular bone score in kidney transplant recipients"
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                          "autores" => array:6 [
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                            1 => "L&#46;M&#46; Lix"
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                            3 => "A&#46;X&#46; Garg"
                            4 => "D&#46;N&#46; Rush"
                            5 => "A&#46;B&#46; Hodsman"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "1115"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26608055"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microindentation for in vivo measurement of bone tissue mechanical properties in humans"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
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                            3 => "E&#46; C&#225;ceres"
                            4 => "M&#46;J&#46; Pe&#241;a"
                            5 => "L&#46; Mellibovsky"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.73"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "1877"
                        "paginaFinal" => "1885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20200991"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vivo assessment of bone quality in postmenopausal women with type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "J&#46;N&#46; Farr"
                            1 => "M&#46;T&#46; Drake"
                            2 => "S&#46; Amin"
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                            4 => "L&#46;K&#46; McCready"
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                    0 => array:2 [
                      "titulo" => "Bone material strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of bone mineral density"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Malgo"
                            1 => "N&#46;A&#46; Hamdy"
                            2 => "S&#46;E&#46; Papapoulos"
                            3 => "N&#46;M&#46; Appelman-Dijkstra"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1210/jc.2014-4346"
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                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2015"
                        "volumen" => "100"
                        "paginaInicial" => "2039"
                        "paginaFinal" => "2045"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25768670"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Bone tissue properties measurement by reference point indentation in glucocorticoid-induced osteoporosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Mellibovsky"
                            1 => "D&#46; Prieto-Alhambra"
                            2 => "F&#46; Mellibovsky"
                            3 => "R&#46; G&#252;erri-Fern&#225;ndez"
                            4 => "X&#46; Nogu&#233;s"
                            5 => "C&#46; Randall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.2497"
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                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2015"
                        "volumen" => "30"
                        "paginaInicial" => "1651"
                        "paginaFinal" => "1656"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25736591"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "40"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Bone material strength is associated with areal BMD but not with prevalent fractures in older women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Rud&#228;ng"
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                            2 => "D&#46; Sundh"
                            3 => "H&#46; Brisby"
                            4 => "A&#46; D&#237;ez-P&#233;rez"
                            5 => "L&#46; Johansson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00198-015-3419-0"
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                        "tituloSerie" => "Osteoporos Int"
                        "fecha" => "2016"
                        "volumen" => "27"
                        "paginaInicial" => "1585"
                        "paginaFinal" => "1592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26630975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0205"
              "etiqueta" => "41"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone density&#44; microarquitecture and tissue quality long-term after kidney transplant"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; P&#233;rez-S&#225;ez"
                            1 => "S&#46; Herrera"
                            2 => "D&#46; Prieto-Alhambra"
                            3 => "X&#46; Nogu&#233;s"
                            4 => "M&#46; Vera"
                            5 => "D&#46; Redondo-Pach&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0000000000001328"
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                        "tituloSerie" => "Transplantation"
                        "fecha" => "2017"
                        "volumen" => "101"
                        "paginaInicial" => "1290"
                        "paginaFinal" => "1294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27467533"
                            "web" => "Medline"
                          ]
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                          "pii" => "S1569199314001568"
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                  ]
                ]
              ]
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              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid avoidance or withdrawal for kidney transplant recipients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Pascual"
                            1 => "J&#46; Zamora"
                            2 => "C&#46; Galeano"
                            3 => "A&#46; Royuela"
                            4 => "C&#46; Quereda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2009"
                        "volumen" => "21"
                        "paginaInicial" => "CD005632"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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ISSN: 20132514
Original language: English
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