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a focal and segmental glomerulofritis and a IgA nephropathy&#46; We present the case of a 65-year-old patient with multiple comorbidity&#44; nephrotic syndrome secondary to focal and segmental glomerulofritis and an IgA nephropathy treated with tacrolimus and drifting into in a Guillain-Barre syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This is a 65-year-old patient who was referred to a nephrology department from primary care in 2014 because of proteinuria and uncontrolled blood pressure&#46; Among the personal history&#44; it can be highlighted in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; He was firstly seen in October 2014 at nephrology consultation&#46; He was in a good general condition&#46; Analysis revealed GFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60 &#40;MDRD&#41; Cr 1&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl Hb 11<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; Na 136<span class="elsevierStyleHsp" style=""></span>mmol&#47;l K 4&#46;3<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; proteinogram with inflammatory profile&#44; good diuresis&#44; unchanged immunological profile&#44; ACRO 3600<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#44; proteinuria of 4<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; no hypoprhoeaemia&#44; Alb 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and TP 6<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; There was no anemia&#46; Immunoglobulins were not altered&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">With a normal abdominal ultrasound&#44; a renal biopsy was performed with a diagnosis of focal and segmental glomerulonegritis&#46; Treatment with corticosteroids was started with a 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day on September 2015&#46; The following month the patient had to be hospitalized in internal medicine presenting an adison crisis in relation to the suppression of the steroids by the patient&#46; The patient remained hospitalized for a few days&#44; the corticotherapy was reintroduced and he was discharged&#46; At January 2016 corticoresistance was verified&#44; a proteinuria of 5&#46;5<span class="elsevierStyleHsp" style=""></span>g in 24<span class="elsevierStyleHsp" style=""></span>h was observed&#46; Treatment with cyclosporine was initiated with a poor response and multiple side effects&#46; Therefore&#44; it was suspended after three months of use and a change to mycophenolate mofetil 1000<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h was made&#46; From October to November the patient was hospitalized do to anasarca and nephrotic syndrome&#46; A second renal biopsy was performed and tacrolimus was initiated adjusted to the levels of &#40;range 8&#8211;12<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; The subsequent biopsy reveals IgA M1 E1 S1 T1 nephropathy in the Oxford classification&#46; The patient appears once again at the emergency room in January 2017&#44; presenting general deterioration with important loss of tone and mobility at the lower limbs&#44; that has been progressive&#46; Subsequently the patient manifested that it started to occur mildly several weeks after the onset of tacrolimus&#46; Given the suspicion&#44; of a possible Demyelinating neuropathy by tacrolimus or a GBS&#44; the consultation to neurology was made and the drug was progressively withdrawal&#46; An MRI of the skull was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Image 1</a>&#41;&#44; a lumbar puncture reflected proteins 76<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and glucose of 68<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Secondary causes of GBS were also discarded&#46; The neurophysiological study was done with the following result&#58; signs of symmetrical generalized peripheral neuropathy &#40;sensory polyneuropathy&#41; of probable axonal origin and moderate-severe intensity&#44; with greater involvement of the lower extremities&#46; However&#44; the symmetrical progression of the affection makes more suspicion a GBS&#46; The patient was seen by psychiatry and rehabilitation&#44; with current monitoring of the two specialties&#46; He continued his treatment with a lower dose prednisone&#46; At discharge his Glomerular Filtration was over 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; a Cr of 1&#46;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and a proteinuria of 6<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Overall condition improved considerably from admission&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">GBS is an uncommon disease with a worldwide incidence of 1&#8211;2 cases per 100&#44;000&#47;year&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> while the incidence of GBS in patients receiving tacrolimus secondary to the nephrotic syndrome is not known&#46; This syndrome&#44; often described as an immunological disorder&#44; has been thought to be rare among immunosuppressed patients&#44; since immunosuppression acts as a protection&#46; The pathophysiology of tacrolimus toxicity is not well studied&#44; although most cases are described in association with high systemic levels of the drug&#46; Although nerve conduction studies in patients with tacrolimus polyneuropathy may also show evidence of demyelinating changes&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> the symmetrical ascending presentation and the absence of a history of elevated tacrolimus levels goes toward the diagnosis of GBS over tacrolimus polyneuropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> The treatment of GBS secondary to tacrolimus in patients with nephrotic syndrome is not known&#44; except the withdraw of the medication&#46; Even this case is exceptionally rare&#44; it is necessary to take into account the presence of this pathology when the medication is used&#44; an early and timely diagnosis&#44; would avoid greater sequelae in all the patients that might be affected&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Jakovler IR&#44; Nieto CP&#44; Antonio MR&#44; Blanco FS&#44; Javier RM&#46; S&#237;ndrome Guillain-Barr&#233; secundario a tacrolimus en paciente con s&#237;ndrome nefr&#243;tico corticorresistente secundario a glomerulonefritis focal y segmentaria y nefropat&#237;a IgA&#46; Nefrologia&#46; 2018&#59;38&#58;665&#8211;666&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No detected allergy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right leg cellulitis in 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ex-smoker&#44; with 1 package per day until 1987&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alcoholic habits until 1987&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Miner from 1977 until retirement in 2003&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Acute renal failure in 2010 in relation to right extremity cellulitis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left cryptorchidia studied by urology with a negative extension study&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Eczema 1999 in probable relation with non-affiliated psoriasis&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right varicose veins&#59; Saphenectomy with ligation in 2000&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                    0 => array:2 [
                      "titulo" => "Guillain-Barre syndrome&#58; modern theories of etiology"
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                          "etal" => false
                          "autores" => array:4 [
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                        "fecha" => "2011"
                        "volumen" => "11"
                        "paginaInicial" => "197"
                        "paginaFinal" => "204"
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                          0 => array:2 [
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunosuppression and the Guillain-Barr&#233; syndrome"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Drachman"
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                            3 => "J&#46; Roguska"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1970"
                        "volumen" => "200"
                        "paginaInicial" => "390"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guillain-Barre syndrome following allogeneic bone marrow transplantation"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;Y&#46; Wen"
                            1 => "E&#46;P&#46; Alyea"
                            2 => "D&#46; Simon"
                            3 => "R&#46;S&#46; Herbst"
                            4 => "R&#46;J&#46; Soiffer"
                            5 => "J&#46;H&#46; Antin"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "paginaFinal" => "1714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9409375"
                            "web" => "Medline"
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                    ]
                  ]
                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurological complications in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Ponticelli"
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                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "521"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and electrophysiological parameters distinguishing acute-onset chronic inflammatory demyelinating polyneuropathy from acute inflammatory demyelinating polyneuropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                        ]
                      ]
                    ]
                  ]
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                      "doi" => "10.1002/mus.21480"
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                        "tituloSerie" => "Muscle Nerve"
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                        "paginaInicial" => "202"
                        "paginaFinal" => "207"
                        "link" => array:1 [
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                0 => array:2 [
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                        "paginaInicial" => "161"
                        "paginaFinal" => "162"
                        "link" => array:1 [
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Letter to the Editor
Guillian-Barre syndrome secondary to tacrolimus in a patient with corticoresistant nephrotic syndrome secondary to focal and segmental glomerulonephritis and a coexisting IgA nephropathy
Síndrome Guillain-Barré secundario a tacrolimus en paciente con síndrome nefrótico corticorresistente secundario a glomerulonefritis focal y segmentaria y nefropatía IgA
Igor Romaniouk Jakovler
Corresponding author
Igor9843@gmail.com

Corresponding author.
, Carmen Perez Nieto, Marco Romero Antonio, Fernando Simal Blanco, Ricardo Mouzo Javier
Nephrology department, El Bierzo Hospital, Ponferrada, Spain
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    "titulo" => "Guillian-Barre syndrome secondary to tacrolimus in a patient with corticoresistant nephrotic syndrome secondary to focal and segmental glomerulonephritis and a coexisting IgA nephropathy"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Guillain-Barre syndrome &#40;GBS&#41; manifests itself as a progressive and symmetrical muscular weakness in lower limbs and arreflexia&#46; Occasionally&#44; patients require invasive ventilation and with a 15&#8211;30&#37; mortality rate&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> The association between respiratory and gastrointestinal infections is well known and occurs in two-thirds of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a> In a solid organ transplant it is a rare complication&#44; however it is slightly more frequent in bone marrow transplantation&#46; However&#44; Guillain-Barre syndrome is an exceptionally rare complication in a nephrotic syndrome patient&#44; treated with tacrolimus and whose renal biopsies reveal the separate entities&#44; a focal and segmental glomerulofritis and a IgA nephropathy&#46; We present the case of a 65-year-old patient with multiple comorbidity&#44; nephrotic syndrome secondary to focal and segmental glomerulofritis and an IgA nephropathy treated with tacrolimus and drifting into in a Guillain-Barre syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This is a 65-year-old patient who was referred to a nephrology department from primary care in 2014 because of proteinuria and uncontrolled blood pressure&#46; Among the personal history&#44; it can be highlighted in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; He was firstly seen in October 2014 at nephrology consultation&#46; He was in a good general condition&#46; Analysis revealed GFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60 &#40;MDRD&#41; Cr 1&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl Hb 11<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; Na 136<span class="elsevierStyleHsp" style=""></span>mmol&#47;l K 4&#46;3<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; proteinogram with inflammatory profile&#44; good diuresis&#44; unchanged immunological profile&#44; ACRO 3600<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#44; proteinuria of 4<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; no hypoprhoeaemia&#44; Alb 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and TP 6<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; There was no anemia&#46; Immunoglobulins were not altered&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">With a normal abdominal ultrasound&#44; a renal biopsy was performed with a diagnosis of focal and segmental glomerulonegritis&#46; Treatment with corticosteroids was started with a 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day on September 2015&#46; The following month the patient had to be hospitalized in internal medicine presenting an adison crisis in relation to the suppression of the steroids by the patient&#46; The patient remained hospitalized for a few days&#44; the corticotherapy was reintroduced and he was discharged&#46; At January 2016 corticoresistance was verified&#44; a proteinuria of 5&#46;5<span class="elsevierStyleHsp" style=""></span>g in 24<span class="elsevierStyleHsp" style=""></span>h was observed&#46; Treatment with cyclosporine was initiated with a poor response and multiple side effects&#46; Therefore&#44; it was suspended after three months of use and a change to mycophenolate mofetil 1000<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h was made&#46; From October to November the patient was hospitalized do to anasarca and nephrotic syndrome&#46; A second renal biopsy was performed and tacrolimus was initiated adjusted to the levels of &#40;range 8&#8211;12<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; The subsequent biopsy reveals IgA M1 E1 S1 T1 nephropathy in the Oxford classification&#46; The patient appears once again at the emergency room in January 2017&#44; presenting general deterioration with important loss of tone and mobility at the lower limbs&#44; that has been progressive&#46; Subsequently the patient manifested that it started to occur mildly several weeks after the onset of tacrolimus&#46; Given the suspicion&#44; of a possible Demyelinating neuropathy by tacrolimus or a GBS&#44; the consultation to neurology was made and the drug was progressively withdrawal&#46; An MRI of the skull was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Image 1</a>&#41;&#44; a lumbar puncture reflected proteins 76<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and glucose of 68<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Secondary causes of GBS were also discarded&#46; The neurophysiological study was done with the following result&#58; signs of symmetrical generalized peripheral neuropathy &#40;sensory polyneuropathy&#41; of probable axonal origin and moderate-severe intensity&#44; with greater involvement of the lower extremities&#46; However&#44; the symmetrical progression of the affection makes more suspicion a GBS&#46; The patient was seen by psychiatry and rehabilitation&#44; with current monitoring of the two specialties&#46; He continued his treatment with a lower dose prednisone&#46; At discharge his Glomerular Filtration was over 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; a Cr of 1&#46;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and a proteinuria of 6<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Overall condition improved considerably from admission&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">GBS is an uncommon disease with a worldwide incidence of 1&#8211;2 cases per 100&#44;000&#47;year&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> while the incidence of GBS in patients receiving tacrolimus secondary to the nephrotic syndrome is not known&#46; This syndrome&#44; often described as an immunological disorder&#44; has been thought to be rare among immunosuppressed patients&#44; since immunosuppression acts as a protection&#46; The pathophysiology of tacrolimus toxicity is not well studied&#44; although most cases are described in association with high systemic levels of the drug&#46; Although nerve conduction studies in patients with tacrolimus polyneuropathy may also show evidence of demyelinating changes&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> the symmetrical ascending presentation and the absence of a history of elevated tacrolimus levels goes toward the diagnosis of GBS over tacrolimus polyneuropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> The treatment of GBS secondary to tacrolimus in patients with nephrotic syndrome is not known&#44; except the withdraw of the medication&#46; Even this case is exceptionally rare&#44; it is necessary to take into account the presence of this pathology when the medication is used&#44; an early and timely diagnosis&#44; would avoid greater sequelae in all the patients that might be affected&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Jakovler IR&#44; Nieto CP&#44; Antonio MR&#44; Blanco FS&#44; Javier RM&#46; S&#237;ndrome Guillain-Barr&#233; secundario a tacrolimus en paciente con s&#237;ndrome nefr&#243;tico corticorresistente secundario a glomerulonefritis focal y segmentaria y nefropat&#237;a IgA&#46; Nefrologia&#46; 2018&#59;38&#58;665&#8211;666&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Right leg cellulitis in 2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ex-smoker&#44; with 1 package per day until 1987&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left cryptorchidia studied by urology with a negative extension study&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right varicose veins&#59; Saphenectomy with ligation in 2000&#46;&nbsp;\t\t\t\t\t\t\n
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                      "titulo" => "Guillain-Barre syndrome&#58; modern theories of etiology"
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                          "etal" => false
                          "autores" => array:4 [
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                          ]
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                        "tituloSerie" => "Curr Allergy Asthma Rep"
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                        "paginaInicial" => "197"
                        "paginaFinal" => "204"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21451970"
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              ]
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                        ]
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                    ]
                  ]
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                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0045"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Guillain-Barre syndrome following allogeneic bone marrow transplantation"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            3 => "R&#46;S&#46; Herbst"
                            4 => "R&#46;J&#46; Soiffer"
                            5 => "J&#46;H&#46; Antin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
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                        "paginaInicial" => "1711"
                        "paginaFinal" => "1714"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9409375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
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                0 => array:2 [
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                      "titulo" => "Neurological complications in kidney transplant recipients"
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                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "521"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
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                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Clinical and electrophysiological parameters distinguishing acute-onset chronic inflammatory demyelinating polyneuropathy from acute inflammatory demyelinating polyneuropathy"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Muscle Nerve"
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                        "paginaInicial" => "202"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
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                    ]
                  ]
                ]
              ]
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                      "titulo" => "Tacrolimus-induced polyneuropathy after heart transplantation"
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                            4 => "A&#46; Quattrone"
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