array:25 [
  "pii" => "S2013251417301943"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2017.11.010"
  "estado" => "S300"
  "fechaPublicacion" => "2017-11-01"
  "aid" => "382"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2017"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2017;37:622-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2180
    "formatos" => array:3 [
      "EPUB" => 260
      "HTML" => 1416
      "PDF" => 504
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699517301029"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2017.03.028"
      "estado" => "S300"
      "fechaPublicacion" => "2017-11-01"
      "aid" => "382"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2017;37:622-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5625
        "formatos" => array:3 [
          "EPUB" => 336
          "HTML" => 4542
          "PDF" => 747
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "622"
            "paginaFinal" => "629"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Anti-inflammatory profile of paricalcitol in kidney transplant recipients"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 983
                "Ancho" => 1472
                "Tamanyo" => 51785
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n de los cocientes de los niveles de expresi&#243;n g&#233;nica de citocinas pro- &#40;TNF-&#945; e IL-6&#41; y antiinflamatorias &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; en el grupo de pacientes tratados con paricalcitol con respecto a los niveles basales&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">U&#46;A&#46;&#58; unidades arbitrarias&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Javier Donate-Correa, Fernando Henr&#237;quez-Palop, Ernesto Mart&#237;n-N&#250;&#241;ez, Carolina Hern&#225;ndez-Carballo, Carla Ferri, Nayra P&#233;rez-Delgado, Mercedes Muros-de-Fuentes, Carmen Mora-Fern&#225;ndez, Juan F&#46; Navarro-Gonz&#225;lez"
            "autores" => array:9 [
              0 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "Donate-Correa"
              ]
              1 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Henr&#237;quez-Palop"
              ]
              2 => array:2 [
                "nombre" => "Ernesto"
                "apellidos" => "Mart&#237;n-N&#250;&#241;ez"
              ]
              3 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Hern&#225;ndez-Carballo"
              ]
              4 => array:2 [
                "nombre" => "Carla"
                "apellidos" => "Ferri"
              ]
              5 => array:2 [
                "nombre" => "Nayra"
                "apellidos" => "P&#233;rez-Delgado"
              ]
              6 => array:2 [
                "nombre" => "Mercedes"
                "apellidos" => "Muros-de-Fuentes"
              ]
              7 => array:2 [
                "nombre" => "Carmen"
                "apellidos" => "Mora-Fern&#225;ndez"
              ]
              8 => array:2 [
                "nombre" => "Juan F&#46;"
                "apellidos" => "Navarro-Gonz&#225;lez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251417301943"
          "doi" => "10.1016/j.nefroe.2017.11.010"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301943?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517301029?idApp=UINPBA000064"
      "url" => "/02116995/0000003700000006/v2_201712010640/S0211699517301029/v2_201712010640/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251417301918"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.11.007"
    "estado" => "S300"
    "fechaPublicacion" => "2017-11-01"
    "aid" => "377"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:630-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2698
      "formatos" => array:3 [
        "EPUB" => 291
        "HTML" => 1785
        "PDF" => 622
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Citrate dialysate does not induce oxidative stress or inflammation in vitro as compared to acetate dialysate"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "630"
          "paginaFinal" => "637"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El l&#237;quido de di&#225;lisis con citrato no induce in vitro estr&#233;s oxidativo ni inflamaci&#243;n en comparaci&#243;n con el acetato"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Fig&#46; 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 1397
              "Ancho" => 1647
              "Tamanyo" => 69702
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ICAM-1 expression and ROS activity in immunocompetent peripheral blood cells from hemodialysis patients&#46; Incubation in the different dialysis fluids did not produce significant differences in the expression of ICAM-1&#46; However ROS activity was increased in cells cultured with acetate containing dialysis fluids as compared with control and citrate fluids&#46; &#40;&#42; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael P&#233;rez-Garc&#237;a, Rafael Ram&#237;rez Chamond, Patricia de Sequera Ortiz, Marta Albalate, Marta Puerta Carretero, Mayra Ortega, M&#46; Caridad Ruiz Caro, Roberto Alcazar Arroyo"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "P&#233;rez-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Ram&#237;rez Chamond"
            ]
            2 => array:2 [
              "nombre" => "Patricia"
              "apellidos" => "de Sequera Ortiz"
            ]
            3 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Albalate"
            ]
            4 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Puerta Carretero"
            ]
            5 => array:2 [
              "nombre" => "Mayra"
              "apellidos" => "Ortega"
            ]
            6 => array:2 [
              "nombre" => "M&#46; Caridad"
              "apellidos" => "Ruiz Caro"
            ]
            7 => array:2 [
              "nombre" => "Roberto"
              "apellidos" => "Alcazar Arroyo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699517300978"
        "doi" => "10.1016/j.nefro.2017.03.024"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517300978?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301918?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301918/v1_201712030528/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251417301955"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.11.011"
    "estado" => "S300"
    "fechaPublicacion" => "2017-11-01"
    "aid" => "390"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:608-21"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3314
      "formatos" => array:3 [
        "EPUB" => 266
        "HTML" => 2358
        "PDF" => 690
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Strategies to increase patient safety in haemodialysis&#58; Application of the modal analysis system of errors and effects &#40;FEMA system&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "608"
          "paginaFinal" => "621"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estrategias para aumentar la seguridad del paciente en hemodi&#225;lisis&#58; Aplicaci&#243;n del sistema de an&#225;lisis modal de fallos y efectos &#40;sistema AMFE&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Dolores Arenas Jim&#233;nez, Gabriel Ferre, Fernando &#193;lvarez-Ude"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Mar&#237;a Dolores"
              "apellidos" => "Arenas Jim&#233;nez"
            ]
            1 => array:2 [
              "nombre" => "Gabriel"
              "apellidos" => "Ferre"
            ]
            2 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "&#193;lvarez-Ude"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699517301108"
        "doi" => "10.1016/j.nefro.2017.04.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517301108?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301955?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301955/v1_201712030528/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Anti-inflammatory profile of paricalcitol in kidney transplant recipients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "622"
        "paginaFinal" => "629"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Javier Donate-Correa, Fernando Henr&#237;quez-Palop, Ernesto Mart&#237;n-N&#250;&#241;ez, Carolina Hern&#225;ndez-Carballo, Carla Ferri, Nayra P&#233;rez-Delgado, Mercedes Muros-de-Fuentes, Carmen Mora-Fern&#225;ndez, Juan F&#46; Navarro-Gonz&#225;lez"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "Javier"
            "apellidos" => "Donate-Correa"
            "email" => array:1 [
              0 => "jdonate&#64;ull&#46;es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Henr&#237;quez-Palop"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ernesto"
            "apellidos" => "Mart&#237;n-N&#250;&#241;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Carolina"
            "apellidos" => "Hern&#225;ndez-Carballo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Carla"
            "apellidos" => "Ferri"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Nayra"
            "apellidos" => "P&#233;rez-Delgado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Mercedes"
            "apellidos" => "Muros-de-Fuentes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Carmen"
            "apellidos" => "Mora-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          8 => array:4 [
            "nombre" => "Juan F&#46;"
            "apellidos" => "Navarro-Gonz&#225;lez"
            "email" => array:1 [
              0 => "jnavgon&#64;gobiernodecanarias&#46;org"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#44; Hospital Universitario de Canarias&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Doctor Negr&#237;n&#44; Las Palmas de Gran Canaria&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de An&#225;lisis Cl&#237;nicos&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding authors</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 983
            "Ancho" => 1472
            "Tamanyo" => 52059
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evolution of the gene expression level ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; in the patient group treated with paricalcitol compared to the baseline levels&#46; A&#46;U&#46;&#58; arbitrary units&#46; &#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Although kidney transplants manage to correct many of the metabolic imbalances derived from uraemia&#44; secondary hyperparathyroidism &#40;SHPT&#41; continues to be present in a high percentage of these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Paricalcitol is a selective vitamin D receptor &#40;VDR&#41; activator used for the prevention and treatment of SHPT&#46; Two recently conducted prospective&#44; randomised clinical trials show a sharp decline in concentrations of intact parathyroid hormone &#40;iPTH&#41; in kidney transplant recipients&#44; in those patients who received paricalcitol&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3</span></a> together with a reduction in frequency of post-transplant SHPT in more than half after one year of follow-up<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">2</span></a> and an attenuation of bone remodelling processes and mineral loss&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> In addition&#44; it causes a reduction in the urinary excretion of proteins which&#44; together with all the above&#44; signals the existence of pleiotropic effects of paricalcitol in this population&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In chronic kidney disease &#40;CKD&#41;&#44; the inflammatory status is associated with several complications&#44; including anaemia&#44; left ventricular hypertrophy&#44; vascular calcification and atherosclerosis&#44; and is an independent predictor of mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">1&#8211;3</span></a> In this scenario&#44; alterations in the regulatory cytokines of the inflammatory process are a key factor in the development of complications and in the increase of morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#8211;8</span></a> In the case of kidney transplant recipients&#44; inflammation has been associated with harmful consequences&#44; such as acute rejection&#44; long-term complications&#44; development of coronary calcification&#44; hypertension&#44; as well as an increase in cardiovascular events and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">9&#8211;13</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Both <span class="elsevierStyleItalic">in vitro</span> and <span class="elsevierStyleItalic">in vivo</span> experimental studies have shown anti-inflammatory effects of paricalcitol&#44; including the attenuation of the expression of inflammatory cytokines&#44; inhibition of kidney inflammation by the sequestration of NF-kB&#44; inhibition of the Wnt pathway&#44; and the blocking of &#946;-catenin mediated gene transcription&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">14&#8211;18</span></a> However&#44; studies that indicate the existence of anti-inflammatory effects of paricalcitol in clinical settings are limited&#44; and none of them were conducted on kidney transplant recipients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This preliminary study was conducted on kidney transplant recipients to determine the effect of administration of oral paricalcitol on serum concentrations and the gene expression profile in peripheral blood mononuclear cells &#40;PBMCs&#41; of inflammatory cytokines&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0030" class="elsevierStylePara elsevierViewall">Prospective&#44; open-label&#44; non-randomised study&#44; which included patients who have had a kidney transplant&#44; conducted under routine clinical practice conditions&#46; The inclusion criteria were&#58; patients over 18 years&#59; stable renal function during the three months prior to the start of the study &#40;stability defined as a variability of the serum creatinine values less than 20&#37; with respect to the last check-up&#41;&#59; serum calcium and phosphorus levels within the normal range&#59; estimated glomerular filtration rate of more than 30<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#59; with no changes to immunosuppressive therapy in the three months beforehand and ability to provide informed consent&#46; The exclusion criteria were&#58; concentration of iPTH less than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#59; existence of previous episodes of acute rejection&#59; known immunological disease&#59; acute inflammatory episodes in the previous three months&#59; positive for hepatitis B&#44; C or HIV&#59; previous treatment with calcimimetics&#44; with vitamin D or with active vitamin D compounds and smoking&#44; alcohol or drug abuse habits&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patients finally included in the study and who had a serum concentration of iPTH greater than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml were treated with paricalcitol orally at a dose of 1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day for three months&#46; Once the three months of treatment were completed&#44; the variation in serum levels of inflammatory cytokines interleukin &#40;IL&#41;-6&#44; IL-10 and tumour necrosis factor &#40;TNF&#41;-&#945; was determined&#44; as well as the variation in the expression of their encoding genes in PBMCs&#46; The study was approved by the centre&#39;s Independent Ethics Committee and conducted in accordance with the Declaration of Helsinki&#44; with the Directive for Clinical Trials in the European Union &#40;2001&#47;20&#47;EC&#41; and following the <span class="elsevierStyleItalic">good clinical practice</span> guidelines&#46; All participants signed an informed consent form prior to inclusion&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Biochemical determinations</span><p id="par0040" class="elsevierStylePara elsevierViewall">All determinations were performed by personnel blinded to the characteristics of the patients and the group to which they were assigned&#46; Blood draws were performed after fasting for 8<span class="elsevierStyleHsp" style=""></span>h&#46; Serum aliquots were frozen at &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C until they were analysed&#46; Routine biochemical parameters were determined using standard methods&#46; Creatinine was measured using a standardised enzymatic method &#40;CREA Plus&#44; Roche Diagnostic&#44; Mannheim&#44; Germany&#41;&#46; The coefficients of variation &#40;intra- and inter-assay&#41; were less than 1&#46;5&#37;&#46; The concentration of serum iPTH was determined by the Roche modular intact PTH assay &#40;Roche Diagnostics Corp&#46;&#44; Indianapolis&#44; IN&#44; USA&#41; &#40;normal reference range&#44; 15&#8211;65<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Serum levels of high-sensitivity C-reactive protein &#40;hs-CRP&#41; were measured using immunoturbidimetric assay &#40;Roche Diagnostics GmbH&#44; Mannheim&#44; Germany&#41; in an automated manner&#59; the sensitivity was 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;l and the coefficients of intra- and inter-assay variability were 1&#46;6 and 8&#46;4&#37;&#44; respectively&#46; TNF-&#945;&#44; IL-6 and IL-10 concentrations were determined using high-sensitivity ELISA &#40;Quantikine Human&#44; R&#38;D Systems&#44; Minneapolis&#44; USA&#41; using a DSXTM-4 plate ELISA processor &#40;Vitro SA&#44; Spain&#41;&#46; Minimum detectable concentrations were 0&#46;10&#59; 0&#46;70 and 0&#46;50<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; respectively&#46; The intra- and inter-assay coefficients of variation were less than 10&#46;8&#37;&#46; All participants were required to provide one 24-hour urine sample for the determination of the creatinine clearance value and the urinary excretion of albumin value&#46; Patients were instructed beforehand on how to collect these urine samples and were given written instructions&#46; The container with the urine was taken to the laboratory the same day as the collection period was completed&#46; Urinary excretion of albumin was measured by immunoturbidimetry &#40;Tina-quant Albumin Assay&#44; Roche Diagnostic&#44; Mannheim&#44; Germany&#41;&#46; Regarding the analytical sensitivity and specificity&#44; the limit of blank was 2<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and the limit of detection was 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; The intra- and inter-assay coefficients of variation were less than 4&#37;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Gene expression in peripheral blood mononuclear cells</span><p id="par0050" class="elsevierStylePara elsevierViewall">All patients had a sample of whole blood taken &#40;2&#46;5<span class="elsevierStyleHsp" style=""></span>ml&#41; at baseline and at the end of the study using PAXgene Blood RNA tubes &#40;BD&#44; Franklin Lakes&#44; NJ&#44; USA&#41;&#46; This blood draw was performed at the same time as that used to restore the serum&#46; The PAXgene Blood RNA Kit &#40;Qiagen&#44; Valencia&#44; CA&#44; USA&#41; was used to extract the total RNA following the manufacturer&#39;s instructions&#44; and it was then stored at &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; The cDNA was synthesised using the High Capacity RNA-to-cDNA kit &#40;Applied Biosystems&#44; Foster City&#44; CA&#44; USA&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">By using the TaqMan probe and quantitative real-time PCR &#40;qRT-PCR&#41; the expression of encoding transcripts for <span class="elsevierStyleItalic">TNF</span>-&#945;&#44; <span class="elsevierStyleItalic">IL-6</span>&#44; <span class="elsevierStyleItalic">IL-10</span> and for <span class="elsevierStyleItalic">glyceraldehyde 3-phosphate dehydrogenase</span> &#40;<span class="elsevierStyleItalic">GApDH</span>&#41; was determined&#46; The commercial reaction mixture used was TaqMan Fast Universal PCR Master Mix &#40;Applied Biosystems&#41; and the TaqMan probes selected for each transcript were&#58; Hs00174128&#95;ml &#91;<span class="elsevierStyleItalic">TNF</span>&#945;&#93;&#44; Hs00985639&#95;ml &#91;<span class="elsevierStyleItalic">IL-6</span>&#93;&#44; Hs0961622&#95;m1 &#91;<span class="elsevierStyleItalic">IL-10</span>&#93; y Hs99999905&#95;m1 &#91;<span class="elsevierStyleItalic">GApDH</span>&#93;&#41;&#46; Amplification was conducted in a thermocycler 7500 Fast Real-Time PCR System &#40;Applied Biosystems&#41;&#46; mRNA levels for each of the genes studied were calculated using relative quantification&#44; using the comparative 2<span class="elsevierStyleSup">&#8722;&#916;&#916;Ct</span> method by normalisation with respect to the expression of <span class="elsevierStyleItalic">GApDH</span>&#46; The determinations of each transcript were made in triplicate and samples without reverse transcription were used as negative controls <span class="elsevierStyleItalic">versus</span> possible DNA contamination&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Given the exploratory nature of the study&#44; no calculation of sample size was performed&#46; Categorical data are presented as absolute values and percentages&#46; Continuous variables are highlighted with mean values<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; The Shapiro&#8211;Wilk <span class="elsevierStyleItalic">W</span>-test was used to determine normality&#46; The baseline comparisons were performed using the Student&#39;s <span class="elsevierStyleItalic">t</span>-test for independent samples if data followed a normal distribution&#44; or using a Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test when data appeared to be highly biased&#46; To compare baseline and final values&#44; the Mann&#8211;Whitney and Wilcoxon tests were used for paired data&#44; as appropriate&#46; Both the serum and gene expression values that did not have a normal distribution were converted to log-values for the calculations&#46; Expression levels of the genes under study were calculated using the Data AssistTM v3&#46;0 Software &#40;Applied Biosystems&#41;&#46; The rest of the calculations were performed in GraphPad InStat &#40;GraphPad Software&#44; San Diego&#44; CA&#44; USA&#41;&#46; All tests were two-tailed&#44; and a <span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Demographic and biochemical parameters</span><p id="par0065" class="elsevierStylePara elsevierViewall">At the start of the study&#44; a total of 74 patients were considered&#44; of whom 43 were not included for the following reasons&#58; eight had an iPTH concentration of less than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; 12 had an acute infectious episode&#44; five had a history of acute rejection&#44; five patients received treatment with nutritional vitamin D and four with active analogues&#44; four patients had a variation in serum creatinine concentration &#62;20&#37; compared to the previous control and the immunosuppressive therapy was modified in five patients&#46; Finally&#44; 31 patients were included in accordance with the inclusion criteria &#40;19 men&#59; mean age 54&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;7 years&#41; who were treated with paricalcitol &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day for three months&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment with paricalcitol was well-tolerated&#44; meaning that all patients completed the study&#44; and it was not necessary to withdraw&#44; even temporarily&#44; the treatment in any case&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding immunosuppressive therapy&#44; all patients received therapy with steroids and with mycophenolate mofetil&#46; Twenty-six patients received tacrolimus and five received an inhibitor of the mTOR &#40;mammalian target of rapamycin&#41; pathway&#46; Finally&#44; 15 patients &#40;48&#37;&#41; were treated with renin-angiotensin system blockers&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the baseline clinical characteristics of the participants&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">After three months of paricalcitol administration&#44; there were no significant changes in renal function &#40;serum creatinine values and creatinine clearance values&#41; or in mineral metabolism parameters &#40;serum phosphorus and calcium and calcium-phosphorus product&#41; except for iPTH &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Thus&#44; iPTH serum concentrations decreased significantly from 216&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml at baseline to 147<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>89<span class="elsevierStyleHsp" style=""></span>pg&#47;ml at the end of the study &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; representing a mean percentage decrease of 31&#46;9&#37; in relation to the baseline values&#46; Similarly&#44; the serum alkaline phosphatase levels also decreased in subjects who received paricalcitol&#46; There were no episodes of hypercalcaemia or hyperphosphataemia during the study&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding the urinary excretion of albumin&#44; there were no significant changes in this parameter&#44; although a decrease of 9&#46;3&#37; was observed from the baseline values &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;057&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Inflammatory profile</span><p id="par0090" class="elsevierStylePara elsevierViewall">The concentration of hs-CRP experienced a significant decrease after treatment with paricalcitol &#40;2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9 <span class="elsevierStyleItalic">vs&#46;</span> 2&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Serum levels of IL-10 following treatment with paricalcitol showed an upward trend &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#41;&#44; while both the IL-6 and TNF-&#945; values decreased significantly &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Thus&#44; in relation to the baseline values&#44; the mean percentage decreases of IL-6 and TNF-&#945; were respectively&#58; 29&#46;08 and 9&#46;58&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; in both cases&#41;&#46; These changes were unrelated to the variations in serum iPTH levels or to the change in the urinary excretion of albumin&#46; The change in the balance between pro- and anti-inflammatory strengths was also evaluated by the evolution of the TNF-&#945; and IL-6 ratios relative to the anti-inflammatory cytokine IL-10&#46; Thus&#44; and compared to the baseline values&#44; significant reductions were observed for both the TNF-&#945;&#47;IL-10 ratio and IL-6&#47;IL-10 ratio&#44; with percentage decrease values of 33 and 36&#46;9&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">In the resulting PBMCs&#44; the evolution of the gene expression levels of pro-inflammatory cytokines <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; were analysed&#46; After three months of oral paricalcitol administration&#44; mRNA levels in these cytokines showed a significant decrease&#44; with a mean percentage value of 14&#46;13 and 34&#46;17&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Meanwhile&#44; the expression level of <span class="elsevierStyleItalic">IL-10</span> showed no significant variations&#46; No correlation was found either between the change in expression levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; and the variations observed in serum concentrations of these cytokines&#46; Finally&#44; the ratios of the expression levels of <span class="elsevierStyleItalic">TNF</span>-&#945; and <span class="elsevierStyleItalic">IL-6</span> with respect to those of <span class="elsevierStyleItalic">IL-10</span> experienced a significant reduction of 45&#46;6&#37; and 13&#46;4&#37;&#44; respectively&#44; after treatment &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; respectively&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">In this study&#44; we evaluated the effects of paricalcitol on the inflammatory profile of kidney transplant patients with persistent SHPT&#46; Recent studies in this field show that treatment with this compound has a positive impact that leads to a greater decrease in iPTH concentrations and a reduction in the frequency of post-transplant SHPT&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3</span></a> In addition&#44; it causes an attenuation in the processes of bone remodelling and mineral loss&#44; as well as a reduction in the urinary excretion of protein&#44; which indicates the existence of beneficial pleiotropic effects derived from the activation of the VDR&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> Our results provide new data in this regard&#44; and point to a modulating effect of the inflammatory profile of kidney transplant patients by paricalcitol&#46; Specifically&#44; the administration of this selective VDR activator causes a significant decrease in serum levels of pro-inflammatory cytokines IL-6 and TNF-&#945;&#44; as well as a reduction in the expression levels of genes <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; in PBMCs&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">According to previous observational studies and several clinical trials&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3&#44;19</span></a> serum iPTH levels showed a rapid decrease after three months of paricalcitol treatment&#44; with a significant mean percentage decrease of 31&#46;9&#37; compared to the baseline values&#44; with no changes in calcium and phosphorous values&#46; In addition&#44; there was a significant reduction in the serum concentration of alkaline phosphatase&#44; which has been observed previously&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">20&#44;21</span></a> This decrease has been associated with a concomitant decrease in iPTH&#44; as well as a suppressing effect of paricalcitol on osteoblasts&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">21</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The increase in urinary albumin excretion is common in kidney transplant recipients&#44; with more than 45&#37; of subjects presenting with proteinuria one year after the transplant&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">22</span></a> In most cases&#44; the degree of proteinuria is below 500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; but even at low levels&#8212;ranging from 150 to 500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#8212;it is a powerful predictor of reduced long-term kidney graft survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">23&#44;24</span></a> In our study&#44; we analysed the evolution of albuminuria and found that it tends to decrease at the end of treatment&#44; which does not become statistically significant&#46; A previous retrospective study also shows a slight&#44; although significant&#44; decrease of proteinuria in 58 kidney transplant patients&#44; after three months of paricalcitol administration&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">19</span></a> Similarly&#44; our results concur with those of a recent clinical trial conducted by Trillini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> where&#44; again&#44; there is a tendency to reduce proteinuria after three months of therapy with paricalcitol&#46; This decrease reached statistical significance at six months of follow-up&#46; Some experimental studies also highlight this association between the use of paricalcitol and the antiproteinuric effects&#44; and point to multiple mechanisms&#44; including the downregulation of the renin&#8211;angiotensin system&#44; the attenuation of renal fibrosis&#44; the stimulation of nephrin synthesis and the anti-inflammatory effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">15&#44;16&#44;25&#44;26</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Activation of the VDR&#44; beyond its classic effects on mineral metabolism&#44; is associated with important pleiotropic capacities&#44; including the regulation of immune functions and the modulation of oxidative stress and inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">27&#44;28</span></a> Although experimental studies have provided solid evidence of the anti-inflammatory effects of paricalcitol as a selective VDR&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">15&#44;29&#44;30</span></a> clinical studies are limited and those which do exist have been conducted with patients with CKD or patients on dialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">31&#8211;34</span></a> This study&#44; approached as proof of concept&#44; is the first one specifically designed to evaluate the potential effects of considering the selective activation of the VDR as a target when modulating the inflammatory profile of kidney transplant patients&#46; Our results show that treatment with paricalcitol is associated with a significant reduction in serum concentrations of the pro-inflammatory cytokines TNF-&#945; and IL-6&#44; as well as a decrease in the TNF-&#945;&#47;IL-10 and IL-6&#47;IL-10 ratios&#46; To our knowledge&#44; only one previous study has analysed these effects in kidney transplant patients&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">19</span></a> In this study&#44; the progression of 58 patients was evaluated retrospectively&#44; and the inflammatory status of the patients was determined only by measuring serum levels of C-reactive protein&#46; This value was considered a tertiary outcome&#46; The results at the end of the study showed a drop in the levels of C-reactive protein after three months of treatment with paricalcitol&#46; This reduction continued to be significant after 24 months of treatment&#46; However&#44; the serum levels of inflammatory cytokines or their gene expression levels were not considered&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study demonstrates that&#44; in addition to its effect on serum concentrations&#44; paricalcitol is able to act on PBMCs by modulating the transcription of genes encoding inflammatory cytokines&#46; In a previous <span class="elsevierStyleItalic">in vitro</span> study&#44; it was observed that paricalcitol was able to reduce the production of baseline TNF-&#945; and IL-8 and lipopolysaccharide-induced production in PBMCs of healthy subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">35</span></a> More recently&#44; it has been confirmed that&#44; by culturing PBMCs isolated from patients with CKD and stimulating them with phytohaemagglutinin A&#44; there is a resulting increase in the production of inflammatory cytokines &#40;IL-17&#44; IL-6&#44; IL-1&#946; and TNF-&#945;&#41;&#46; However&#44; if the cells are obtained from patients with CKD who received paricalcitol&#44; there is a significant decrease in the production of these cytokines compared to patients who did not receive the treatment and who recovered baseline values similar to those of the cells of healthy subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">35</span></a> In our study&#44; we determined that mRNA levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; in PBMCs show significant reductions of 14 and 34&#37; compared to baseline values &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; after treatment with paricalcitol&#46; A similar effect of paricalcitol on gene expression of inflammatory cytokines in PBMCs has been observed in patients with CKD and on haemodialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">33&#44;34</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Nowadays&#44; atherosclerosis is considered to be an inflammatory disease&#46; In turn&#44; inflammation is characterised by activation in peripheral blood of immunocompetent cells&#44; leading to the production of inflammatory cytokines&#46; In addition&#44; the activation and ingress of PBMCs from the blood circulation into the vascular wall is a critical step in the pathogenesis of atherosclerosis<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">36&#44;37</span></a> and&#44; from a clinical perspective&#44; the increase in the expression of inflammatory cytokines in PBMCs is related to cardiovascular disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">38&#8211;40</span></a> It is therefore possible to speculate that the anti-inflammatory capacity of paricalcitol&#44; a pleiotropic and extraskeletal effect&#44; may be associated with a positive clinical impact&#44; similar to that seen in patients undergoing haemodialysis&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">41</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Although this study presents new information&#44; we have to recognise certain limitations&#46; As a result of the exploratory nature of this study&#44; it was not conducted following a randomised design&#46; The sample size was small&#44; and the follow-up period of the patients was short&#44; which may have determined that some of the results have not reached statistical significance and&#44; therefore&#44; we have not been able to draw definitive conclusions&#46; In addition&#44; the effects of paricalcitol therapy were not compared with those produced by vitamin D or with another of its active metabolites&#46; However&#44; based on the homogeneity of the study in terms of the general care&#44; follow-up and the therapeutic approach of the patients&#44; that did not vary during the study&#44; it can be assumed that the results obtained are due to the treatment with paricalcitol&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In conclusion&#44; the results of this study show that the selective activation of the VDR by paricalcitol in kidney transplant patients is associated with a modulating and beneficial effect on the serum inflammatory profile and on the cytokine gene expression in PBMCs&#44; resulting in a favourable impact on the balance between pro-inflammatory cytokines &#40;IL-6 and TNF-&#945;&#41; and anti-inflammatory cytokine IL-10&#46; These findings indicate that the benefits of paricalcitol therapy observed previously in patients with CKD and dialysis may be extended to kidney transplant recipients&#46; Long-term prospective trials&#44; which are properly conducted&#44; are needed in order to achieve a better assessment of the potential impact of this treatment and of the translation of these pleiotropic beneficial effects on the clinical results in kidney transplant recipients&#44; including graft survival and the morbidity and mortality of the patient&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">JDC&#44; MMF&#44; CMF and JFNG are members of RETIC &#40;Thematic Networks of Corporate Research&#41;&#47;REDinREN &#40;Kidney Disease Research Network&#41;&#47;RD16&#47;0009&#47;0022&#44; &#40;ISCIII &#8211; Carlos III Health Institute&#41; and GEENDIAB &#40;Diabetic Nephropathy Working Group of the Spanish Society of Nephrology&#41;&#46; The research activity of JDC&#44; EMN and JFNG is funded by the <span class="elsevierStyleGrantSponsor" id="gs1">ISCIII</span> &#40;CD16&#47;00165&#44; FI14&#47;00033 and INT15&#47;00004&#44; respectively&#41;&#46; This study has been partly funded by research grants from the <span class="elsevierStyleGrantSponsor" id="gs2">Spanish Society of Nephrology</span> &#40;SEN&#41; and the <span class="elsevierStyleGrantSponsor" id="gs3">Scientific Association for Nephrology Research &#40;ACINEF&#41;</span>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Authorship&#47;collaborations</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors JDN&#44; EHP and EMN have contributed equally to the preparation of this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres950373"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background and objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec922223"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres950374"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes y objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec922222"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Biochemical determinations"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Gene expression in peripheral blood mononuclear cells"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Demographic and biochemical parameters"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Inflammatory profile"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Authorship&#47;collaborations"
        ]
        10 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflicts of interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-12-05"
    "fechaAceptado" => "2017-03-27"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec922223"
          "palabras" => array:3 [
            0 => "Kidney transplantation"
            1 => "Paricalcitol"
            2 => "Inflammatory cytokines"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec922222"
          "palabras" => array:3 [
            0 => "Trasplante renal"
            1 => "Paricalcitol"
            2 => "Citocinas inflamatorias"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol&#44; a selective vitamin D receptor activator&#44; is used to treat secondary hyperparathyroidism in kidney transplant patients&#46; Experimental and clinical studies in non-transplant kidney disease patients have found this molecule to have anti-inflammatory properties&#46; In this exploratory study&#44; we evaluated the anti-inflammatory profile of paricalcitol in kidney-transplant recipients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thirty one kidney transplant recipients with secondary hyperparathyroidism completed 3 months of treatment with oral paricalcitol &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#46; Serum concentrations and gene expression levels of inflammatory cytokines in peripheral blood mononuclear cells were analysed at the beginning and end of the study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol significantly decreased parathyroid hormone levels with no changes in calcium and phosphorous&#46; It also reduced serum concentrations of interleukin &#40;IL&#41;-6 and tumour necrosis factor-alpha &#40;TNF-&#945;&#41; by 29&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and 9&#46;5&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; compared to baseline&#44; respectively&#46; Furthermore&#44; gene expression levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF-&#945;</span> in peripheral blood mononuclear cells decreased by 14&#46;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and 34&#46;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; respectively&#46; The ratios between pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;IL-10&#41;&#44; both regarding serum concentrations and gene expression&#44; also experienced a significant reduction&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol administration to kidney transplant recipients has been found to have beneficial effects on inflammation&#44; which may be associated with potential clinical benefits&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El paricalcitol&#44; un activador selectivo del receptor de la vitamina D&#44; se utiliza en el tratamiento del hiperparatiroidismo secundario en el receptor de trasplante renal&#46; Estudios tanto cl&#237;nicos como experimentales realizados en pacientes renales no trasplantados muestran propiedades antiinflamatorias para esta mol&#233;cula&#46; En este estudio exploratorio&#44; hemos evaluado el perfil antiinflamatorio del paricalcitol en receptores de trasplante renal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Treinta y un pacientes trasplantados con hiperparatiroidismo secundario completaron 3 meses de terapia con paricalcitol oral &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#237;a&#41;&#46; Se determinaron las concentraciones s&#233;ricas y los niveles de expresi&#243;n g&#233;nica de citocinas inflamatorias en c&#233;lulas mononucleares de sangre perif&#233;rica al inicio y al final del estudio&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El paricalcitol provoc&#243; una disminuci&#243;n significativa en los niveles de hormona paratiroidea&#44; sin cambios en los de calcio y f&#243;sforo&#46; Adem&#225;s&#44; indujo una reducci&#243;n en las concentraciones s&#233;ricas de la interleucina &#40;IL&#41;-6 y del factor de necrosis tumoral alfa &#40;TNF-&#945;&#41;&#44; con reducciones porcentuales respecto al estado basal de un 29&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; y de un 9&#44;5&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; respectivamente&#46; Los niveles de expresi&#243;n g&#233;nica de la IL-6 y del TNF-&#945; en c&#233;lulas mononucleares de sangre perif&#233;rica experimentaron un descenso de un 14&#44;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y de un 34&#44;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; respectivamente&#46; La proporci&#243;n entre las citocinas proinflamatorias &#40;TNF-&#945; e IL-6&#41; y la antiinflamatoria IL-10&#44; tanto para los niveles s&#233;ricos como para los de expresi&#243;n g&#233;nica&#44; tambi&#233;n disminuy&#243; significativamente&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n del paricalcitol a receptores de trasplante renal se asocia con efectos beneficiosos sobre su estado inflamatorio&#44; lo que podr&#237;a asociarse a un potencial beneficio cl&#237;nico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Donate-Correa J&#44; Henr&#237;quez-Palop F&#44; Mart&#237;n-N&#250;&#241;ez E&#44; Hern&#225;ndez-Carballo C&#44; Ferri C&#44; P&#233;rez-Delgado N&#44; et al&#46; Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal&#46; Nefrologia&#46; 2017&#59;37&#58;622&#8211;629&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 972
            "Ancho" => 1449
            "Tamanyo" => 50936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evolution of the serum concentration ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;IL-10&#41; in the patient group treated with paricalcitol compared to the baseline levels &#40;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 983
            "Ancho" => 1472
            "Tamanyo" => 52059
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evolution of the gene expression level ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; in the patient group treated with paricalcitol compared to the baseline levels&#46; A&#46;U&#46;&#58; arbitrary units&#46; &#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#59; Cr&#58; creatinine&#59; IL&#58; interleukin&#59; iPTH&#58; intact parathyroid hormone&#59; IU&#58; international units&#59; NS&#58; not significant&#59; TNF-&#945;&#58; tumour necrosis factor alpha&#59; UAE&#58; urinary excretion of albumin&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Paricalcitol &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Men &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;61&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes mellitus &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;48&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Time after transplant &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum Cr &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cr clearance &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum calcium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum phosphate &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum magnesium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alkaline phosphatase &#40;IU&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum iPTH &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">216&#46;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum 25-OH Vitamin D &#40;ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum albumin &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">UAE &#40;mg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">158&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>151&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum TNF-&#945; &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-6 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-10 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1609178.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Baseline clinical characteristics of the patients included in the study&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cr&#58; creatinine&#59; hs-CRP&#58; high-sensitivity C-reactive protein&#59; IL&#58; interleukin&#59; iPTH&#58; intact parathyroid hormone&#59; IU&#58; international units&#59; NS&#58; not significant&#59; TNF-&#945;&#58; tumour necrosis factor alpha&#59; UAE&#58; urinary excretion of albumin&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Paricalcitol &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;</th><th class="td" title="table-head  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">3 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum Cr &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cr clearance &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum iPTH &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">216<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">147<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alkaline phosphatase &#40;IU&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum calcium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum phosphate &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;23<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">UAE &#40;mg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>151&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">144&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>121&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hs-CRP &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum TNF-&#945; &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-6 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-10 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1609179.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Biochemical characteristics of the patients at the start and end of the study&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:41 [
            0 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone disease after renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;G&#46; Heaf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000043926.74349.6D"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2003"
                        "volumen" => "75"
                        "paginaInicial" => "315"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism&#58; results of an open label randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Amer"
                            1 => "M&#46;D&#46; Griffin"
                            2 => "M&#46;D&#46; Stegall"
                            3 => "F&#46;G&#46; Cosio"
                            4 => "W&#46;D&#46; Park"
                            5 => "W&#46;K&#46; Kremers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12227"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "1576"
                        "paginaFinal" => "1585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23601186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol for secondary hyperparathyroidism in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Trillini"
                            1 => "M&#46; Cortinovis"
                            2 => "P&#46; Ruggenenti"
                            3 => "J&#46; Reyes Loaeza"
                            4 => "K&#46; Courville"
                            5 => "C&#46; Ferrer-Siles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2013111185"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2015"
                        "volumen" => "26"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25194004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation enhances cardiovascular risk and mortality in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Zimmermann"
                            1 => "S&#46; Herrlinger"
                            2 => "A&#46; Pruy"
                            3 => "T&#46; Metzger"
                            4 => "C&#46; Wanner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.1999.00273.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1999"
                        "volumen" => "55"
                        "paginaInicial" => "648"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9987089"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in end-stage renal disease&#58; the hidden enemy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Stenvinkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nephrology &#40;Carlton&#41;"
                        "fecha" => "2006"
                        "volumen" => "11"
                        "paginaInicial" => "36"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory syndrome in patients on hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Jofr&#233;"
                            1 => "P&#46; Rodr&#237;guez-Ben&#237;tez"
                            2 => "J&#46;M&#46; L&#243;pez-G&#243;mez"
                            3 => "R&#46; P&#233;rez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2006080926"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "S274"
                        "paginaFinal" => "S280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17130274"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2215036614703293"
                          "estado" => "S300"
                          "issn" => "22150366"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations of the cytokine network in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Tetta"
                            1 => "S&#46; David"
                            2 => "F&#46; Mariano"
                            3 => "C&#46; De Nitti"
                            4 => "V&#46; Panichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "paginaInicial" => "S22"
                        "paginaFinal" => "S29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11798142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-10&#44; IL-6&#44; and TNF-a central factors in the altered cytokine network of uremia&#8212;the good&#44; the bad&#44; and the ugly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Stenvinkel"
                            1 => "M&#46; Ketteler"
                            2 => "R&#46;J&#46; Johnson"
                            3 => "B&#46; Lindholm"
                            4 => "R&#46; Pecoits-Filho"
                            5 => "M&#46; Riella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2005.00200.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2005"
                        "volumen" => "67"
                        "paginaInicial" => "1216"
                        "paginaFinal" => "1233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15780075"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CRP and acute renal rejection&#58; a marker to the point"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Roshdy"
                            1 => "M&#46;M&#46; El-Khatib"
                            2 => "M&#46;N&#46; Rizk"
                            3 => "A&#46;M&#46; El-Shehaby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11255-011-0098-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Urol Nephrol"
                        "fecha" => "2012"
                        "volumen" => "44"
                        "paginaInicial" => "1251"
                        "paginaFinal" => "1255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22213063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation-associated graft loss in renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;O&#46; Dahle"
                            1 => "G&#46; Mj&#248;en"
                            2 => "B&#46; Oqvist"
                            3 => "H&#46; Scharnagl"
                            4 => "G&#46; Weihrauch"
                            5 => "T&#46; Grammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr163"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "3756"
                        "paginaFinal" => "3761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21511816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and atherosclerosis are associated with hypertension in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Azancot"
                            1 => "N&#46; Ramos"
                            2 => "I&#46;B&#46; Torres"
                            3 => "C&#46; Garc&#237;a-Carro"
                            4 => "K&#46; Romero"
                            5 => "E&#46; Espinel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Hypertens &#40;Greenwich&#41;"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "963"
                        "paginaFinal" => "969"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation&#44; coronary artery calcification and cardiovascular events in incident renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Roe"
                            1 => "M&#46; Wolfe"
                            2 => "M&#46; Joffe"
                            3 => "S&#46;E&#46; Rosas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2010.05.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2010"
                        "volumen" => "212"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20934074"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Abedini"
                            1 => "I&#46; Holme"
                            2 => "W&#46; M&#228;rz"
                            3 => "G&#46; Weihrauch"
                            4 => "B&#46; Fellstr&#246;m"
                            5 => "A&#46; Jardine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.00930209"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "1246"
                        "paginaFinal" => "1254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19541816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt&#47;beta-catenin activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Mart&#237;nez-Moreno"
                            1 => "J&#46;R&#46; Mu&#241;oz-Casta&#241;eda"
                            2 => "C&#46; Herencia"
                            3 => "A&#46;M&#46; Oca"
                            4 => "J&#46;C&#46; Estepa"
                            5 => "R&#46; Canalejo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajprenal.00684.2011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Renal Physiol"
                        "fecha" => "2012"
                        "volumen" => "303"
                        "paginaInicial" => "F1136"
                        "paginaFinal" => "F1144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22874762"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kB signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Tan"
                            1 => "X&#46; Wen"
                            2 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2007060666"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "1741"
                        "paginaFinal" => "1752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18525004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Tan"
                            1 => "W&#46; He"
                            2 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2009.346"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2009"
                        "volumen" => "76"
                        "paginaInicial" => "1248"
                        "paginaFinal" => "1257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19759524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blockade of Wnt&#47;&#946;-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; He"
                            1 => "Y&#46;S&#46; Kang"
                            2 => "C&#46; Dai"
                            3 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2009121236"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2011"
                        "volumen" => "22"
                        "paginaInicial" => "90"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21030600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of vitamin D derivates on vascular calcification associated to inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Guerrero"
                            1 => "A&#46; Montes de Oca"
                            2 => "E&#46; Aguilera-Tejero"
                            3 => "R&#46; Zafra"
                            4 => "M&#46; Rodr&#237;guez"
                            5 => "I&#46; L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr555"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "2206"
                        "paginaFinal" => "2212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22025118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of oral paricalcitol on secondary hyperparathyroidism and proteinuria of kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Gonz&#225;lez"
                            1 => "J&#46; Rojas-Rivera"
                            2 => "N&#46; Polanco"
                            3 => "E&#46; Morales"
                            4 => "J&#46;M&#46; Morales"
                            5 => "J&#46; Egido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e3182855565"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2013"
                        "volumen" => "95"
                        "paginaInicial" => "e49"
                        "paginaFinal" => "e52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23545517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of paricalcitol on mineral bone metabolism in kidney transplant recipients with secondary hyperparathyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Borrego Utiel"
                            1 => "J&#46;A&#46; Bravo Soto"
                            2 => "M&#46;J&#46; Merino P&#233;rez"
                            3 => "I&#46; Gonz&#225;lez Carmelo"
                            4 => "V&#46; L&#243;pez Jim&#233;nez"
                            5 => "T&#46; Garc&#237;a &#193;lvarez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nefro.2015.06.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2015"
                        "volumen" => "35"
                        "paginaInicial" => "363"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26306956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy&#58; results of the VITAL study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;W&#46; Coyne"
                            1 => "D&#46;L&#46; Andress"
                            2 => "M&#46;J&#46; Amdahl"
                            3 => "E&#46; Ritz"
                            4 => "E&#46; de Zeeuw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft227"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "2260"
                        "paginaFinal" => "2268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23787544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteinuria&#58; a new marker of long-term graft and patient survival in kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Fern&#225;ndez-Fresnedo"
                            1 => "J&#46;J&#46; Plaza"
                            2 => "J&#46; S&#225;nchez-Plumed"
                            3 => "A&#46; Sanz-Guajardo"
                            4 => "R&#46; Palomar-Fontanet"
                            5 => "M&#46; Arias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "47"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14671038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteinuria after kidney transplantation&#44; relationship to allograft histology and survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Amer"
                            1 => "M&#46;E&#46; Fidler"
                            2 => "M&#46; Myslak"
                            3 => "P&#46; Morales"
                            4 => "W&#46;K&#46; Kremers"
                            5 => "T&#46;S&#46; Larson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-6143.2007.02006.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2007"
                        "volumen" => "7"
                        "paginaInicial" => "2748"
                        "paginaFinal" => "2756"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17941956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-grade proteinuria and oligoalbuminuria in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Halimi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e31828719fb"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2013"
                        "volumen" => "96"
                        "paginaInicial" => "121"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23435457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of renin&#8211;angiotensin gene expression in the kidney by paricalcitol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Freundlich"
                            1 => "Y&#46; Quiroz"
                            2 => "Z&#46; Zhang"
                            3 => "Y&#46; Zhang"
                            4 => "Y&#46; Bravo"
                            5 => "J&#46;R&#46; Weisinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2008.408"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2008"
                        "volumen" => "74"
                        "paginaInicial" => "1394"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18813285"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin D and proteinuria&#58; a critical review of molecular bases and clinical experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;V&#46; P&#233;rez-G&#243;mez"
                            1 => "A&#46; Ortiz-Ardu&#225;n"
                            2 => "V&#46; Lorenzo-Sellar&#233;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Apr.12025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "716"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24089164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonclassical aspects of differential vitamin D receptor activation&#58; implications for survival in patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Andress"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drugs"
                        "fecha" => "2007"
                        "volumen" => "67"
                        "paginaInicial" => "1999"
                        "paginaFinal" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17883284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pleiotropic actions of vitamin D"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Lin"
                            1 => "J&#46;H&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/bies.10368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioessays"
                        "fecha" => "2004"
                        "volumen" => "26"
                        "paginaInicial" => "21"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14696037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beyond proteinuria&#58; VDR activation reduces renal inflammation in experimental diabetic nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Sanchez-Ni&#241;o"
                            1 => "M&#46; Bozic"
                            2 => "E&#46; C&#243;rdoba-Lanus"
                            3 => "P&#46; Valcheva"
                            4 => "O&#46; Gracia"
                            5 => "M&#46; Ibarz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol Renal Physiol"
                        "fecha" => "2011"
                        "volumen" => "302"
                        "paginaInicial" => "647"
                        "paginaFinal" => "657"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;S&#46; Kim"
                            1 => "S&#46;Y&#46; Joo"
                            2 => "K&#46;E&#46; Lee"
                            3 => "J&#46;S&#46; Choi"
                            4 => "E&#46;H&#46; Bae"
                            5 => "S&#46;K&#46; Ma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "e63186"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces albuminuria and inflammation in chronic kidney disease&#58; a randomized double-blind pilot trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Alborzi"
                            1 => "N&#46;A&#46; Patel"
                            2 => "C&#46; Peterson"
                            3 => "J&#46;E&#46; Bills"
                            4 => "D&#46;M&#46; Bekele"
                            5 => "Z&#46; Bunaye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.108.113159"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2008"
                        "volumen" => "52"
                        "paginaInicial" => "249"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18606901"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Izquierdo"
                            1 => "M&#46; Cavia"
                            2 => "P&#46; Mu&#241;iz"
                            3 => "A&#46;L&#46; de Francisco"
                            4 => "M&#46; Arias"
                            5 => "J&#46; Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-13-159"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2012"
                        "volumen" => "13"
                        "paginaInicial" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23186077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Selective vitamin D receptor activation as an anti-inflammatory target in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Donate-Correa"
                            1 => "V&#46; Dom&#237;nguez-Pimentel"
                            2 => "M&#46;L&#46; M&#233;ndez-P&#233;rez"
                            3 => "M&#46; Muros-de-Fuentes"
                            4 => "C&#46; Mora-Fern&#225;ndez"
                            5 => "E&#46; Mart&#237;n-N&#250;&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/670475"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mediators Inflamm"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "670475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24511210"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-inflammatory profile of paricalcitol in hemodialysis patients&#58; a prospective&#44; open-label&#44; pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;F&#46; Navarro-Gonz&#225;lez"
                            1 => "J&#46; Donate-Correa"
                            2 => "M&#46;L&#46; M&#233;ndez"
                            3 => "M&#46; Muros de Fuentes"
                            4 => "J&#46; Garc&#237;a-P&#233;rez"
                            5 => "C&#46; Mora-Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcph.19"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "2013"
                        "volumen" => "53"
                        "paginaInicial" => "421"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23426718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces basal and lipopolysaccharide-induced &#40;LPS&#41; TNF-alpha and IL-8 production by human peripheral blood mononuclear cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Eleftheriadis"
                            1 => "G&#46; Antoniadi"
                            2 => "V&#46; Liakopoulos"
                            3 => "C&#46; Kartsios"
                            4 => "I&#46; Stefanidis"
                            5 => "G&#46; Galaktidou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11255-009-9541-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Urol Nephrol"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "181"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19259778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of paricalcitol in modulating the immune response in patients with renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lucisano"
                            1 => "A&#46; Arena"
                            2 => "G&#46; Stassi"
                            3 => "D&#46; Iannello"
                            4 => "G&#46; Montalto"
                            5 => "A&#46; Romeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2015/765364"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Endocrinol"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "765364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26451144"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Points to control in inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Nathan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature01320"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2002"
                        "volumen" => "420"
                        "paginaInicial" => "846"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12490957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune and inflammatory mechanisms of atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Galkina"
                            1 => "K&#46; Ley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev.immunol.021908.132620"
                      "Revista" => array:6 [
                        "tituloSerie" => "Annu Rev Immunol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "165"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19302038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased IL-1beta IL-8&#44; and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Kostulas"
                            1 => "S&#46; Pelidou"
                            2 => "P&#46; Kivis&#228;kk"
                            3 => "V&#46; Kostulas"
                            4 => "H&#46; Link"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1999"
                        "volumen" => "30"
                        "paginaInicial" => "2174"
                        "paginaFinal" => "2179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10512924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased mRNA expression of tumour necrosis factor-alpha and its converting enzyme in circulating leucocytes of patients with acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Akatsu"
                            1 => "M&#46; Nakamura"
                            2 => "M&#46; Satoh"
                            3 => "K&#46; Hiramori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/CS20020367"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "2003"
                        "volumen" => "105"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12605594"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Teng"
                            1 => "M&#46; Wolf"
                            2 => "E&#46; Lowrie"
                            3 => "N&#46; Ofsthun"
                            4 => "J&#46;M&#46; Lazarus"
                            5 => "R&#46; Thadhani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa022536"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "446"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12890843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301943/v1_201712030528/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42660"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003700000006/v1_201712030528/S2013251417301943/v1_201712030528/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301943?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original article
Anti-inflammatory profile of paricalcitol in kidney transplant recipients
Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal
Javier Donate-Correaa,b,
Corresponding author
jdonate@ull.es

Corresponding authors.
, Fernando Henríquez-Palopc, Ernesto Martín-Núñeza, Carolina Hernández-Carballoa, Carla Ferria, Nayra Pérez-Delgadod, Mercedes Muros-de-Fuentesd, Carmen Mora-Fernándeza, Juan F. Navarro-Gonzáleza,e,
Corresponding author
jnavgon@gobiernodecanarias.org

Corresponding authors.
a Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
b Unidad de Investigación, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
c Servicio de Nefrología, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain
d Servicio de Análisis Clínicos, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
e Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
Read
6888
Times
was read the article
2359
Total PDF
4529
Total HTML
Share statistics
 array:25 [
  "pii" => "S2013251417301943"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2017.11.010"
  "estado" => "S300"
  "fechaPublicacion" => "2017-11-01"
  "aid" => "382"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2017"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:622-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2180
    "formatos" => array:3 [
      "EPUB" => 260
      "HTML" => 1416
      "PDF" => 504
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699517301029"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2017.03.028"
      "estado" => "S300"
      "fechaPublicacion" => "2017-11-01"
      "aid" => "382"
      "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2017;37:622-9"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5625
        "formatos" => array:3 [
          "EPUB" => 336
          "HTML" => 4542
          "PDF" => 747
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "622"
            "paginaFinal" => "629"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Anti-inflammatory profile of paricalcitol in kidney transplant recipients"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 983
                "Ancho" => 1472
                "Tamanyo" => 51785
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n de los cocientes de los niveles de expresi&#243;n g&#233;nica de citocinas pro- &#40;TNF-&#945; e IL-6&#41; y antiinflamatorias &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; en el grupo de pacientes tratados con paricalcitol con respecto a los niveles basales&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">U&#46;A&#46;&#58; unidades arbitrarias&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Javier Donate-Correa, Fernando Henr&#237;quez-Palop, Ernesto Mart&#237;n-N&#250;&#241;ez, Carolina Hern&#225;ndez-Carballo, Carla Ferri, Nayra P&#233;rez-Delgado, Mercedes Muros-de-Fuentes, Carmen Mora-Fern&#225;ndez, Juan F&#46; Navarro-Gonz&#225;lez"
            "autores" => array:9 [
              0 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "Donate-Correa"
              ]
              1 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Henr&#237;quez-Palop"
              ]
              2 => array:2 [
                "nombre" => "Ernesto"
                "apellidos" => "Mart&#237;n-N&#250;&#241;ez"
              ]
              3 => array:2 [
                "nombre" => "Carolina"
                "apellidos" => "Hern&#225;ndez-Carballo"
              ]
              4 => array:2 [
                "nombre" => "Carla"
                "apellidos" => "Ferri"
              ]
              5 => array:2 [
                "nombre" => "Nayra"
                "apellidos" => "P&#233;rez-Delgado"
              ]
              6 => array:2 [
                "nombre" => "Mercedes"
                "apellidos" => "Muros-de-Fuentes"
              ]
              7 => array:2 [
                "nombre" => "Carmen"
                "apellidos" => "Mora-Fern&#225;ndez"
              ]
              8 => array:2 [
                "nombre" => "Juan F&#46;"
                "apellidos" => "Navarro-Gonz&#225;lez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251417301943"
          "doi" => "10.1016/j.nefroe.2017.11.010"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301943?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517301029?idApp=UINPBA000064"
      "url" => "/02116995/0000003700000006/v2_201712010640/S0211699517301029/v2_201712010640/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251417301918"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.11.007"
    "estado" => "S300"
    "fechaPublicacion" => "2017-11-01"
    "aid" => "377"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:630-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2698
      "formatos" => array:3 [
        "EPUB" => 291
        "HTML" => 1785
        "PDF" => 622
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Citrate dialysate does not induce oxidative stress or inflammation in vitro as compared to acetate dialysate"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "630"
          "paginaFinal" => "637"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El l&#237;quido de di&#225;lisis con citrato no induce in vitro estr&#233;s oxidativo ni inflamaci&#243;n en comparaci&#243;n con el acetato"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Fig&#46; 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 1397
              "Ancho" => 1647
              "Tamanyo" => 69702
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ICAM-1 expression and ROS activity in immunocompetent peripheral blood cells from hemodialysis patients&#46; Incubation in the different dialysis fluids did not produce significant differences in the expression of ICAM-1&#46; However ROS activity was increased in cells cultured with acetate containing dialysis fluids as compared with control and citrate fluids&#46; &#40;&#42; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael P&#233;rez-Garc&#237;a, Rafael Ram&#237;rez Chamond, Patricia de Sequera Ortiz, Marta Albalate, Marta Puerta Carretero, Mayra Ortega, M&#46; Caridad Ruiz Caro, Roberto Alcazar Arroyo"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "P&#233;rez-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "Ram&#237;rez Chamond"
            ]
            2 => array:2 [
              "nombre" => "Patricia"
              "apellidos" => "de Sequera Ortiz"
            ]
            3 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Albalate"
            ]
            4 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Puerta Carretero"
            ]
            5 => array:2 [
              "nombre" => "Mayra"
              "apellidos" => "Ortega"
            ]
            6 => array:2 [
              "nombre" => "M&#46; Caridad"
              "apellidos" => "Ruiz Caro"
            ]
            7 => array:2 [
              "nombre" => "Roberto"
              "apellidos" => "Alcazar Arroyo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699517300978"
        "doi" => "10.1016/j.nefro.2017.03.024"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517300978?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301918?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301918/v1_201712030528/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251417301955"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.11.011"
    "estado" => "S300"
    "fechaPublicacion" => "2017-11-01"
    "aid" => "390"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:608-21"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3314
      "formatos" => array:3 [
        "EPUB" => 266
        "HTML" => 2358
        "PDF" => 690
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Strategies to increase patient safety in haemodialysis&#58; Application of the modal analysis system of errors and effects &#40;FEMA system&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "608"
          "paginaFinal" => "621"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Estrategias para aumentar la seguridad del paciente en hemodi&#225;lisis&#58; Aplicaci&#243;n del sistema de an&#225;lisis modal de fallos y efectos &#40;sistema AMFE&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Dolores Arenas Jim&#233;nez, Gabriel Ferre, Fernando &#193;lvarez-Ude"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Mar&#237;a Dolores"
              "apellidos" => "Arenas Jim&#233;nez"
            ]
            1 => array:2 [
              "nombre" => "Gabriel"
              "apellidos" => "Ferre"
            ]
            2 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "&#193;lvarez-Ude"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699517301108"
        "doi" => "10.1016/j.nefro.2017.04.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699517301108?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301955?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301955/v1_201712030528/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Anti-inflammatory profile of paricalcitol in kidney transplant recipients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "622"
        "paginaFinal" => "629"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Javier Donate-Correa, Fernando Henr&#237;quez-Palop, Ernesto Mart&#237;n-N&#250;&#241;ez, Carolina Hern&#225;ndez-Carballo, Carla Ferri, Nayra P&#233;rez-Delgado, Mercedes Muros-de-Fuentes, Carmen Mora-Fern&#225;ndez, Juan F&#46; Navarro-Gonz&#225;lez"
        "autores" => array:9 [
          0 => array:4 [
            "nombre" => "Javier"
            "apellidos" => "Donate-Correa"
            "email" => array:1 [
              0 => "jdonate&#64;ull&#46;es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Fernando"
            "apellidos" => "Henr&#237;quez-Palop"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Ernesto"
            "apellidos" => "Mart&#237;n-N&#250;&#241;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Carolina"
            "apellidos" => "Hern&#225;ndez-Carballo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Carla"
            "apellidos" => "Ferri"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Nayra"
            "apellidos" => "P&#233;rez-Delgado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Mercedes"
            "apellidos" => "Muros-de-Fuentes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Carmen"
            "apellidos" => "Mora-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          8 => array:4 [
            "nombre" => "Juan F&#46;"
            "apellidos" => "Navarro-Gonz&#225;lez"
            "email" => array:1 [
              0 => "jnavgon&#64;gobiernodecanarias&#46;org"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n&#44; Hospital Universitario de Canarias&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Doctor Negr&#237;n&#44; Las Palmas de Gran Canaria&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de An&#225;lisis Cl&#237;nicos&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Universitario Nuestra Se&#241;ora de Candelaria&#44; Santa Cruz de Tenerife&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding authors</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 983
            "Ancho" => 1472
            "Tamanyo" => 52059
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evolution of the gene expression level ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; in the patient group treated with paricalcitol compared to the baseline levels&#46; A&#46;U&#46;&#58; arbitrary units&#46; &#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Although kidney transplants manage to correct many of the metabolic imbalances derived from uraemia&#44; secondary hyperparathyroidism &#40;SHPT&#41; continues to be present in a high percentage of these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Paricalcitol is a selective vitamin D receptor &#40;VDR&#41; activator used for the prevention and treatment of SHPT&#46; Two recently conducted prospective&#44; randomised clinical trials show a sharp decline in concentrations of intact parathyroid hormone &#40;iPTH&#41; in kidney transplant recipients&#44; in those patients who received paricalcitol&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3</span></a> together with a reduction in frequency of post-transplant SHPT in more than half after one year of follow-up<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">2</span></a> and an attenuation of bone remodelling processes and mineral loss&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> In addition&#44; it causes a reduction in the urinary excretion of proteins which&#44; together with all the above&#44; signals the existence of pleiotropic effects of paricalcitol in this population&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In chronic kidney disease &#40;CKD&#41;&#44; the inflammatory status is associated with several complications&#44; including anaemia&#44; left ventricular hypertrophy&#44; vascular calcification and atherosclerosis&#44; and is an independent predictor of mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">1&#8211;3</span></a> In this scenario&#44; alterations in the regulatory cytokines of the inflammatory process are a key factor in the development of complications and in the increase of morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#8211;8</span></a> In the case of kidney transplant recipients&#44; inflammation has been associated with harmful consequences&#44; such as acute rejection&#44; long-term complications&#44; development of coronary calcification&#44; hypertension&#44; as well as an increase in cardiovascular events and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">9&#8211;13</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Both <span class="elsevierStyleItalic">in vitro</span> and <span class="elsevierStyleItalic">in vivo</span> experimental studies have shown anti-inflammatory effects of paricalcitol&#44; including the attenuation of the expression of inflammatory cytokines&#44; inhibition of kidney inflammation by the sequestration of NF-kB&#44; inhibition of the Wnt pathway&#44; and the blocking of &#946;-catenin mediated gene transcription&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">14&#8211;18</span></a> However&#44; studies that indicate the existence of anti-inflammatory effects of paricalcitol in clinical settings are limited&#44; and none of them were conducted on kidney transplant recipients&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This preliminary study was conducted on kidney transplant recipients to determine the effect of administration of oral paricalcitol on serum concentrations and the gene expression profile in peripheral blood mononuclear cells &#40;PBMCs&#41; of inflammatory cytokines&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0030" class="elsevierStylePara elsevierViewall">Prospective&#44; open-label&#44; non-randomised study&#44; which included patients who have had a kidney transplant&#44; conducted under routine clinical practice conditions&#46; The inclusion criteria were&#58; patients over 18 years&#59; stable renal function during the three months prior to the start of the study &#40;stability defined as a variability of the serum creatinine values less than 20&#37; with respect to the last check-up&#41;&#59; serum calcium and phosphorus levels within the normal range&#59; estimated glomerular filtration rate of more than 30<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#59; with no changes to immunosuppressive therapy in the three months beforehand and ability to provide informed consent&#46; The exclusion criteria were&#58; concentration of iPTH less than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#59; existence of previous episodes of acute rejection&#59; known immunological disease&#59; acute inflammatory episodes in the previous three months&#59; positive for hepatitis B&#44; C or HIV&#59; previous treatment with calcimimetics&#44; with vitamin D or with active vitamin D compounds and smoking&#44; alcohol or drug abuse habits&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patients finally included in the study and who had a serum concentration of iPTH greater than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml were treated with paricalcitol orally at a dose of 1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day for three months&#46; Once the three months of treatment were completed&#44; the variation in serum levels of inflammatory cytokines interleukin &#40;IL&#41;-6&#44; IL-10 and tumour necrosis factor &#40;TNF&#41;-&#945; was determined&#44; as well as the variation in the expression of their encoding genes in PBMCs&#46; The study was approved by the centre&#39;s Independent Ethics Committee and conducted in accordance with the Declaration of Helsinki&#44; with the Directive for Clinical Trials in the European Union &#40;2001&#47;20&#47;EC&#41; and following the <span class="elsevierStyleItalic">good clinical practice</span> guidelines&#46; All participants signed an informed consent form prior to inclusion&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Biochemical determinations</span><p id="par0040" class="elsevierStylePara elsevierViewall">All determinations were performed by personnel blinded to the characteristics of the patients and the group to which they were assigned&#46; Blood draws were performed after fasting for 8<span class="elsevierStyleHsp" style=""></span>h&#46; Serum aliquots were frozen at &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C until they were analysed&#46; Routine biochemical parameters were determined using standard methods&#46; Creatinine was measured using a standardised enzymatic method &#40;CREA Plus&#44; Roche Diagnostic&#44; Mannheim&#44; Germany&#41;&#46; The coefficients of variation &#40;intra- and inter-assay&#41; were less than 1&#46;5&#37;&#46; The concentration of serum iPTH was determined by the Roche modular intact PTH assay &#40;Roche Diagnostics Corp&#46;&#44; Indianapolis&#44; IN&#44; USA&#41; &#40;normal reference range&#44; 15&#8211;65<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Serum levels of high-sensitivity C-reactive protein &#40;hs-CRP&#41; were measured using immunoturbidimetric assay &#40;Roche Diagnostics GmbH&#44; Mannheim&#44; Germany&#41; in an automated manner&#59; the sensitivity was 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;l and the coefficients of intra- and inter-assay variability were 1&#46;6 and 8&#46;4&#37;&#44; respectively&#46; TNF-&#945;&#44; IL-6 and IL-10 concentrations were determined using high-sensitivity ELISA &#40;Quantikine Human&#44; R&#38;D Systems&#44; Minneapolis&#44; USA&#41; using a DSXTM-4 plate ELISA processor &#40;Vitro SA&#44; Spain&#41;&#46; Minimum detectable concentrations were 0&#46;10&#59; 0&#46;70 and 0&#46;50<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; respectively&#46; The intra- and inter-assay coefficients of variation were less than 10&#46;8&#37;&#46; All participants were required to provide one 24-hour urine sample for the determination of the creatinine clearance value and the urinary excretion of albumin value&#46; Patients were instructed beforehand on how to collect these urine samples and were given written instructions&#46; The container with the urine was taken to the laboratory the same day as the collection period was completed&#46; Urinary excretion of albumin was measured by immunoturbidimetry &#40;Tina-quant Albumin Assay&#44; Roche Diagnostic&#44; Mannheim&#44; Germany&#41;&#46; Regarding the analytical sensitivity and specificity&#44; the limit of blank was 2<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and the limit of detection was 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; The intra- and inter-assay coefficients of variation were less than 4&#37;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Gene expression in peripheral blood mononuclear cells</span><p id="par0050" class="elsevierStylePara elsevierViewall">All patients had a sample of whole blood taken &#40;2&#46;5<span class="elsevierStyleHsp" style=""></span>ml&#41; at baseline and at the end of the study using PAXgene Blood RNA tubes &#40;BD&#44; Franklin Lakes&#44; NJ&#44; USA&#41;&#46; This blood draw was performed at the same time as that used to restore the serum&#46; The PAXgene Blood RNA Kit &#40;Qiagen&#44; Valencia&#44; CA&#44; USA&#41; was used to extract the total RNA following the manufacturer&#39;s instructions&#44; and it was then stored at &#8722;80<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; The cDNA was synthesised using the High Capacity RNA-to-cDNA kit &#40;Applied Biosystems&#44; Foster City&#44; CA&#44; USA&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">By using the TaqMan probe and quantitative real-time PCR &#40;qRT-PCR&#41; the expression of encoding transcripts for <span class="elsevierStyleItalic">TNF</span>-&#945;&#44; <span class="elsevierStyleItalic">IL-6</span>&#44; <span class="elsevierStyleItalic">IL-10</span> and for <span class="elsevierStyleItalic">glyceraldehyde 3-phosphate dehydrogenase</span> &#40;<span class="elsevierStyleItalic">GApDH</span>&#41; was determined&#46; The commercial reaction mixture used was TaqMan Fast Universal PCR Master Mix &#40;Applied Biosystems&#41; and the TaqMan probes selected for each transcript were&#58; Hs00174128&#95;ml &#91;<span class="elsevierStyleItalic">TNF</span>&#945;&#93;&#44; Hs00985639&#95;ml &#91;<span class="elsevierStyleItalic">IL-6</span>&#93;&#44; Hs0961622&#95;m1 &#91;<span class="elsevierStyleItalic">IL-10</span>&#93; y Hs99999905&#95;m1 &#91;<span class="elsevierStyleItalic">GApDH</span>&#93;&#41;&#46; Amplification was conducted in a thermocycler 7500 Fast Real-Time PCR System &#40;Applied Biosystems&#41;&#46; mRNA levels for each of the genes studied were calculated using relative quantification&#44; using the comparative 2<span class="elsevierStyleSup">&#8722;&#916;&#916;Ct</span> method by normalisation with respect to the expression of <span class="elsevierStyleItalic">GApDH</span>&#46; The determinations of each transcript were made in triplicate and samples without reverse transcription were used as negative controls <span class="elsevierStyleItalic">versus</span> possible DNA contamination&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Given the exploratory nature of the study&#44; no calculation of sample size was performed&#46; Categorical data are presented as absolute values and percentages&#46; Continuous variables are highlighted with mean values<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#46; The Shapiro&#8211;Wilk <span class="elsevierStyleItalic">W</span>-test was used to determine normality&#46; The baseline comparisons were performed using the Student&#39;s <span class="elsevierStyleItalic">t</span>-test for independent samples if data followed a normal distribution&#44; or using a Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test when data appeared to be highly biased&#46; To compare baseline and final values&#44; the Mann&#8211;Whitney and Wilcoxon tests were used for paired data&#44; as appropriate&#46; Both the serum and gene expression values that did not have a normal distribution were converted to log-values for the calculations&#46; Expression levels of the genes under study were calculated using the Data AssistTM v3&#46;0 Software &#40;Applied Biosystems&#41;&#46; The rest of the calculations were performed in GraphPad InStat &#40;GraphPad Software&#44; San Diego&#44; CA&#44; USA&#41;&#46; All tests were two-tailed&#44; and a <span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Demographic and biochemical parameters</span><p id="par0065" class="elsevierStylePara elsevierViewall">At the start of the study&#44; a total of 74 patients were considered&#44; of whom 43 were not included for the following reasons&#58; eight had an iPTH concentration of less than 100<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; 12 had an acute infectious episode&#44; five had a history of acute rejection&#44; five patients received treatment with nutritional vitamin D and four with active analogues&#44; four patients had a variation in serum creatinine concentration &#62;20&#37; compared to the previous control and the immunosuppressive therapy was modified in five patients&#46; Finally&#44; 31 patients were included in accordance with the inclusion criteria &#40;19 men&#59; mean age 54&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;7 years&#41; who were treated with paricalcitol &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day for three months&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Treatment with paricalcitol was well-tolerated&#44; meaning that all patients completed the study&#44; and it was not necessary to withdraw&#44; even temporarily&#44; the treatment in any case&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding immunosuppressive therapy&#44; all patients received therapy with steroids and with mycophenolate mofetil&#46; Twenty-six patients received tacrolimus and five received an inhibitor of the mTOR &#40;mammalian target of rapamycin&#41; pathway&#46; Finally&#44; 15 patients &#40;48&#37;&#41; were treated with renin-angiotensin system blockers&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the baseline clinical characteristics of the participants&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">After three months of paricalcitol administration&#44; there were no significant changes in renal function &#40;serum creatinine values and creatinine clearance values&#41; or in mineral metabolism parameters &#40;serum phosphorus and calcium and calcium-phosphorus product&#41; except for iPTH &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Thus&#44; iPTH serum concentrations decreased significantly from 216&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml at baseline to 147<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>89<span class="elsevierStyleHsp" style=""></span>pg&#47;ml at the end of the study &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; representing a mean percentage decrease of 31&#46;9&#37; in relation to the baseline values&#46; Similarly&#44; the serum alkaline phosphatase levels also decreased in subjects who received paricalcitol&#46; There were no episodes of hypercalcaemia or hyperphosphataemia during the study&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding the urinary excretion of albumin&#44; there were no significant changes in this parameter&#44; although a decrease of 9&#46;3&#37; was observed from the baseline values &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;057&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Inflammatory profile</span><p id="par0090" class="elsevierStylePara elsevierViewall">The concentration of hs-CRP experienced a significant decrease after treatment with paricalcitol &#40;2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9 <span class="elsevierStyleItalic">vs&#46;</span> 2&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;4&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Serum levels of IL-10 following treatment with paricalcitol showed an upward trend &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#41;&#44; while both the IL-6 and TNF-&#945; values decreased significantly &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Thus&#44; in relation to the baseline values&#44; the mean percentage decreases of IL-6 and TNF-&#945; were respectively&#58; 29&#46;08 and 9&#46;58&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; in both cases&#41;&#46; These changes were unrelated to the variations in serum iPTH levels or to the change in the urinary excretion of albumin&#46; The change in the balance between pro- and anti-inflammatory strengths was also evaluated by the evolution of the TNF-&#945; and IL-6 ratios relative to the anti-inflammatory cytokine IL-10&#46; Thus&#44; and compared to the baseline values&#44; significant reductions were observed for both the TNF-&#945;&#47;IL-10 ratio and IL-6&#47;IL-10 ratio&#44; with percentage decrease values of 33 and 36&#46;9&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">In the resulting PBMCs&#44; the evolution of the gene expression levels of pro-inflammatory cytokines <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; were analysed&#46; After three months of oral paricalcitol administration&#44; mRNA levels in these cytokines showed a significant decrease&#44; with a mean percentage value of 14&#46;13 and 34&#46;17&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Meanwhile&#44; the expression level of <span class="elsevierStyleItalic">IL-10</span> showed no significant variations&#46; No correlation was found either between the change in expression levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; and the variations observed in serum concentrations of these cytokines&#46; Finally&#44; the ratios of the expression levels of <span class="elsevierStyleItalic">TNF</span>-&#945; and <span class="elsevierStyleItalic">IL-6</span> with respect to those of <span class="elsevierStyleItalic">IL-10</span> experienced a significant reduction of 45&#46;6&#37; and 13&#46;4&#37;&#44; respectively&#44; after treatment &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01 and <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; respectively&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">In this study&#44; we evaluated the effects of paricalcitol on the inflammatory profile of kidney transplant patients with persistent SHPT&#46; Recent studies in this field show that treatment with this compound has a positive impact that leads to a greater decrease in iPTH concentrations and a reduction in the frequency of post-transplant SHPT&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3</span></a> In addition&#44; it causes an attenuation in the processes of bone remodelling and mineral loss&#44; as well as a reduction in the urinary excretion of protein&#44; which indicates the existence of beneficial pleiotropic effects derived from the activation of the VDR&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> Our results provide new data in this regard&#44; and point to a modulating effect of the inflammatory profile of kidney transplant patients by paricalcitol&#46; Specifically&#44; the administration of this selective VDR activator causes a significant decrease in serum levels of pro-inflammatory cytokines IL-6 and TNF-&#945;&#44; as well as a reduction in the expression levels of genes <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; in PBMCs&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">According to previous observational studies and several clinical trials&#44;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">2&#44;3&#44;19</span></a> serum iPTH levels showed a rapid decrease after three months of paricalcitol treatment&#44; with a significant mean percentage decrease of 31&#46;9&#37; compared to the baseline values&#44; with no changes in calcium and phosphorous values&#46; In addition&#44; there was a significant reduction in the serum concentration of alkaline phosphatase&#44; which has been observed previously&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">20&#44;21</span></a> This decrease has been associated with a concomitant decrease in iPTH&#44; as well as a suppressing effect of paricalcitol on osteoblasts&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">21</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The increase in urinary albumin excretion is common in kidney transplant recipients&#44; with more than 45&#37; of subjects presenting with proteinuria one year after the transplant&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">22</span></a> In most cases&#44; the degree of proteinuria is below 500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; but even at low levels&#8212;ranging from 150 to 500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#8212;it is a powerful predictor of reduced long-term kidney graft survival&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">23&#44;24</span></a> In our study&#44; we analysed the evolution of albuminuria and found that it tends to decrease at the end of treatment&#44; which does not become statistically significant&#46; A previous retrospective study also shows a slight&#44; although significant&#44; decrease of proteinuria in 58 kidney transplant patients&#44; after three months of paricalcitol administration&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">19</span></a> Similarly&#44; our results concur with those of a recent clinical trial conducted by Trillini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a> where&#44; again&#44; there is a tendency to reduce proteinuria after three months of therapy with paricalcitol&#46; This decrease reached statistical significance at six months of follow-up&#46; Some experimental studies also highlight this association between the use of paricalcitol and the antiproteinuric effects&#44; and point to multiple mechanisms&#44; including the downregulation of the renin&#8211;angiotensin system&#44; the attenuation of renal fibrosis&#44; the stimulation of nephrin synthesis and the anti-inflammatory effect&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">15&#44;16&#44;25&#44;26</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Activation of the VDR&#44; beyond its classic effects on mineral metabolism&#44; is associated with important pleiotropic capacities&#44; including the regulation of immune functions and the modulation of oxidative stress and inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">27&#44;28</span></a> Although experimental studies have provided solid evidence of the anti-inflammatory effects of paricalcitol as a selective VDR&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">15&#44;29&#44;30</span></a> clinical studies are limited and those which do exist have been conducted with patients with CKD or patients on dialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">31&#8211;34</span></a> This study&#44; approached as proof of concept&#44; is the first one specifically designed to evaluate the potential effects of considering the selective activation of the VDR as a target when modulating the inflammatory profile of kidney transplant patients&#46; Our results show that treatment with paricalcitol is associated with a significant reduction in serum concentrations of the pro-inflammatory cytokines TNF-&#945; and IL-6&#44; as well as a decrease in the TNF-&#945;&#47;IL-10 and IL-6&#47;IL-10 ratios&#46; To our knowledge&#44; only one previous study has analysed these effects in kidney transplant patients&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">19</span></a> In this study&#44; the progression of 58 patients was evaluated retrospectively&#44; and the inflammatory status of the patients was determined only by measuring serum levels of C-reactive protein&#46; This value was considered a tertiary outcome&#46; The results at the end of the study showed a drop in the levels of C-reactive protein after three months of treatment with paricalcitol&#46; This reduction continued to be significant after 24 months of treatment&#46; However&#44; the serum levels of inflammatory cytokines or their gene expression levels were not considered&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study demonstrates that&#44; in addition to its effect on serum concentrations&#44; paricalcitol is able to act on PBMCs by modulating the transcription of genes encoding inflammatory cytokines&#46; In a previous <span class="elsevierStyleItalic">in vitro</span> study&#44; it was observed that paricalcitol was able to reduce the production of baseline TNF-&#945; and IL-8 and lipopolysaccharide-induced production in PBMCs of healthy subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">35</span></a> More recently&#44; it has been confirmed that&#44; by culturing PBMCs isolated from patients with CKD and stimulating them with phytohaemagglutinin A&#44; there is a resulting increase in the production of inflammatory cytokines &#40;IL-17&#44; IL-6&#44; IL-1&#946; and TNF-&#945;&#41;&#46; However&#44; if the cells are obtained from patients with CKD who received paricalcitol&#44; there is a significant decrease in the production of these cytokines compared to patients who did not receive the treatment and who recovered baseline values similar to those of the cells of healthy subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">35</span></a> In our study&#44; we determined that mRNA levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF</span>-&#945; in PBMCs show significant reductions of 14 and 34&#37; compared to baseline values &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; after treatment with paricalcitol&#46; A similar effect of paricalcitol on gene expression of inflammatory cytokines in PBMCs has been observed in patients with CKD and on haemodialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">33&#44;34</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Nowadays&#44; atherosclerosis is considered to be an inflammatory disease&#46; In turn&#44; inflammation is characterised by activation in peripheral blood of immunocompetent cells&#44; leading to the production of inflammatory cytokines&#46; In addition&#44; the activation and ingress of PBMCs from the blood circulation into the vascular wall is a critical step in the pathogenesis of atherosclerosis<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">36&#44;37</span></a> and&#44; from a clinical perspective&#44; the increase in the expression of inflammatory cytokines in PBMCs is related to cardiovascular disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">38&#8211;40</span></a> It is therefore possible to speculate that the anti-inflammatory capacity of paricalcitol&#44; a pleiotropic and extraskeletal effect&#44; may be associated with a positive clinical impact&#44; similar to that seen in patients undergoing haemodialysis&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">41</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Although this study presents new information&#44; we have to recognise certain limitations&#46; As a result of the exploratory nature of this study&#44; it was not conducted following a randomised design&#46; The sample size was small&#44; and the follow-up period of the patients was short&#44; which may have determined that some of the results have not reached statistical significance and&#44; therefore&#44; we have not been able to draw definitive conclusions&#46; In addition&#44; the effects of paricalcitol therapy were not compared with those produced by vitamin D or with another of its active metabolites&#46; However&#44; based on the homogeneity of the study in terms of the general care&#44; follow-up and the therapeutic approach of the patients&#44; that did not vary during the study&#44; it can be assumed that the results obtained are due to the treatment with paricalcitol&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In conclusion&#44; the results of this study show that the selective activation of the VDR by paricalcitol in kidney transplant patients is associated with a modulating and beneficial effect on the serum inflammatory profile and on the cytokine gene expression in PBMCs&#44; resulting in a favourable impact on the balance between pro-inflammatory cytokines &#40;IL-6 and TNF-&#945;&#41; and anti-inflammatory cytokine IL-10&#46; These findings indicate that the benefits of paricalcitol therapy observed previously in patients with CKD and dialysis may be extended to kidney transplant recipients&#46; Long-term prospective trials&#44; which are properly conducted&#44; are needed in order to achieve a better assessment of the potential impact of this treatment and of the translation of these pleiotropic beneficial effects on the clinical results in kidney transplant recipients&#44; including graft survival and the morbidity and mortality of the patient&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">JDC&#44; MMF&#44; CMF and JFNG are members of RETIC &#40;Thematic Networks of Corporate Research&#41;&#47;REDinREN &#40;Kidney Disease Research Network&#41;&#47;RD16&#47;0009&#47;0022&#44; &#40;ISCIII &#8211; Carlos III Health Institute&#41; and GEENDIAB &#40;Diabetic Nephropathy Working Group of the Spanish Society of Nephrology&#41;&#46; The research activity of JDC&#44; EMN and JFNG is funded by the <span class="elsevierStyleGrantSponsor" id="gs1">ISCIII</span> &#40;CD16&#47;00165&#44; FI14&#47;00033 and INT15&#47;00004&#44; respectively&#41;&#46; This study has been partly funded by research grants from the <span class="elsevierStyleGrantSponsor" id="gs2">Spanish Society of Nephrology</span> &#40;SEN&#41; and the <span class="elsevierStyleGrantSponsor" id="gs3">Scientific Association for Nephrology Research &#40;ACINEF&#41;</span>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Authorship&#47;collaborations</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors JDN&#44; EHP and EMN have contributed equally to the preparation of this article&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres950373"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background and objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec922223"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres950374"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes y objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec922222"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Biochemical determinations"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Gene expression in peripheral blood mononuclear cells"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Demographic and biochemical parameters"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Inflammatory profile"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Authorship&#47;collaborations"
        ]
        10 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflicts of interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-12-05"
    "fechaAceptado" => "2017-03-27"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec922223"
          "palabras" => array:3 [
            0 => "Kidney transplantation"
            1 => "Paricalcitol"
            2 => "Inflammatory cytokines"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec922222"
          "palabras" => array:3 [
            0 => "Trasplante renal"
            1 => "Paricalcitol"
            2 => "Citocinas inflamatorias"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol&#44; a selective vitamin D receptor activator&#44; is used to treat secondary hyperparathyroidism in kidney transplant patients&#46; Experimental and clinical studies in non-transplant kidney disease patients have found this molecule to have anti-inflammatory properties&#46; In this exploratory study&#44; we evaluated the anti-inflammatory profile of paricalcitol in kidney-transplant recipients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Thirty one kidney transplant recipients with secondary hyperparathyroidism completed 3 months of treatment with oral paricalcitol &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#46; Serum concentrations and gene expression levels of inflammatory cytokines in peripheral blood mononuclear cells were analysed at the beginning and end of the study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol significantly decreased parathyroid hormone levels with no changes in calcium and phosphorous&#46; It also reduced serum concentrations of interleukin &#40;IL&#41;-6 and tumour necrosis factor-alpha &#40;TNF-&#945;&#41; by 29&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and 9&#46;5&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; compared to baseline&#44; respectively&#46; Furthermore&#44; gene expression levels of <span class="elsevierStyleItalic">IL-6</span> and <span class="elsevierStyleItalic">TNF-&#945;</span> in peripheral blood mononuclear cells decreased by 14&#46;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and 34&#46;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; respectively&#46; The ratios between pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;IL-10&#41;&#44; both regarding serum concentrations and gene expression&#44; also experienced a significant reduction&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Paricalcitol administration to kidney transplant recipients has been found to have beneficial effects on inflammation&#44; which may be associated with potential clinical benefits&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El paricalcitol&#44; un activador selectivo del receptor de la vitamina D&#44; se utiliza en el tratamiento del hiperparatiroidismo secundario en el receptor de trasplante renal&#46; Estudios tanto cl&#237;nicos como experimentales realizados en pacientes renales no trasplantados muestran propiedades antiinflamatorias para esta mol&#233;cula&#46; En este estudio exploratorio&#44; hemos evaluado el perfil antiinflamatorio del paricalcitol en receptores de trasplante renal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Treinta y un pacientes trasplantados con hiperparatiroidismo secundario completaron 3 meses de terapia con paricalcitol oral &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;d&#237;a&#41;&#46; Se determinaron las concentraciones s&#233;ricas y los niveles de expresi&#243;n g&#233;nica de citocinas inflamatorias en c&#233;lulas mononucleares de sangre perif&#233;rica al inicio y al final del estudio&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El paricalcitol provoc&#243; una disminuci&#243;n significativa en los niveles de hormona paratiroidea&#44; sin cambios en los de calcio y f&#243;sforo&#46; Adem&#225;s&#44; indujo una reducci&#243;n en las concentraciones s&#233;ricas de la interleucina &#40;IL&#41;-6 y del factor de necrosis tumoral alfa &#40;TNF-&#945;&#41;&#44; con reducciones porcentuales respecto al estado basal de un 29&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; y de un 9&#44;5&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; respectivamente&#46; Los niveles de expresi&#243;n g&#233;nica de la IL-6 y del TNF-&#945; en c&#233;lulas mononucleares de sangre perif&#233;rica experimentaron un descenso de un 14&#44;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y de un 34&#44;1&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; respectivamente&#46; La proporci&#243;n entre las citocinas proinflamatorias &#40;TNF-&#945; e IL-6&#41; y la antiinflamatoria IL-10&#44; tanto para los niveles s&#233;ricos como para los de expresi&#243;n g&#233;nica&#44; tambi&#233;n disminuy&#243; significativamente&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n del paricalcitol a receptores de trasplante renal se asocia con efectos beneficiosos sobre su estado inflamatorio&#44; lo que podr&#237;a asociarse a un potencial beneficio cl&#237;nico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Donate-Correa J&#44; Henr&#237;quez-Palop F&#44; Mart&#237;n-N&#250;&#241;ez E&#44; Hern&#225;ndez-Carballo C&#44; Ferri C&#44; P&#233;rez-Delgado N&#44; et al&#46; Perfil antiinflamatorio del paricalcitol en el receptor de trasplante renal&#46; Nefrologia&#46; 2017&#59;37&#58;622&#8211;629&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 972
            "Ancho" => 1449
            "Tamanyo" => 50936
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evolution of the serum concentration ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;IL-10&#41; in the patient group treated with paricalcitol compared to the baseline levels &#40;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 983
            "Ancho" => 1472
            "Tamanyo" => 52059
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evolution of the gene expression level ratios of pro-inflammatory cytokines &#40;TNF-&#945; and IL-6&#41; and anti-inflammatory cytokines &#40;<span class="elsevierStyleItalic">IL-10</span>&#41; in the patient group treated with paricalcitol compared to the baseline levels&#46; A&#46;U&#46;&#58; arbitrary units&#46; &#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#42;&#42;&#42;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#59; Cr&#58; creatinine&#59; IL&#58; interleukin&#59; iPTH&#58; intact parathyroid hormone&#59; IU&#58; international units&#59; NS&#58; not significant&#59; TNF-&#945;&#58; tumour necrosis factor alpha&#59; UAE&#58; urinary excretion of albumin&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Paricalcitol &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Men &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;61&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes mellitus &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;48&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Time after transplant &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum Cr &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cr clearance &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum calcium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum phosphate &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum magnesium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alkaline phosphatase &#40;IU&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum iPTH &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">216&#46;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum 25-OH Vitamin D &#40;ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum albumin &#40;g&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">UAE &#40;mg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">158&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>151&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum TNF-&#945; &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-6 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-10 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1609178.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Baseline clinical characteristics of the patients included in the study&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cr&#58; creatinine&#59; hs-CRP&#58; high-sensitivity C-reactive protein&#59; IL&#58; interleukin&#59; iPTH&#58; intact parathyroid hormone&#59; IU&#58; international units&#59; NS&#58; not significant&#59; TNF-&#945;&#58; tumour necrosis factor alpha&#59; UAE&#58; urinary excretion of albumin&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Paricalcitol &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;</th><th class="td" title="table-head  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">3 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum Cr &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cr clearance &#40;ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum iPTH &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">216<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">147<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alkaline phosphatase &#40;IU&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum calcium &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum phosphate &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;23<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">UAE &#40;mg&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>151&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">144&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>121&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hs-CRP &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum TNF-&#945; &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-6 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serum IL-10 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1609179.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Biochemical characteristics of the patients at the start and end of the study&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:41 [
            0 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone disease after renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;G&#46; Heaf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.TP.0000043926.74349.6D"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2003"
                        "volumen" => "75"
                        "paginaInicial" => "315"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589151"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism&#58; results of an open label randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Amer"
                            1 => "M&#46;D&#46; Griffin"
                            2 => "M&#46;D&#46; Stegall"
                            3 => "F&#46;G&#46; Cosio"
                            4 => "W&#46;D&#46; Park"
                            5 => "W&#46;K&#46; Kremers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/ajt.12227"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "1576"
                        "paginaFinal" => "1585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23601186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol for secondary hyperparathyroidism in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Trillini"
                            1 => "M&#46; Cortinovis"
                            2 => "P&#46; Ruggenenti"
                            3 => "J&#46; Reyes Loaeza"
                            4 => "K&#46; Courville"
                            5 => "C&#46; Ferrer-Siles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2013111185"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2015"
                        "volumen" => "26"
                        "paginaInicial" => "1205"
                        "paginaFinal" => "1214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25194004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation enhances cardiovascular risk and mortality in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Zimmermann"
                            1 => "S&#46; Herrlinger"
                            2 => "A&#46; Pruy"
                            3 => "T&#46; Metzger"
                            4 => "C&#46; Wanner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.1999.00273.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1999"
                        "volumen" => "55"
                        "paginaInicial" => "648"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9987089"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in end-stage renal disease&#58; the hidden enemy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Stenvinkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nephrology &#40;Carlton&#41;"
                        "fecha" => "2006"
                        "volumen" => "11"
                        "paginaInicial" => "36"
                        "paginaFinal" => "41"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory syndrome in patients on hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Jofr&#233;"
                            1 => "P&#46; Rodr&#237;guez-Ben&#237;tez"
                            2 => "J&#46;M&#46; L&#243;pez-G&#243;mez"
                            3 => "R&#46; P&#233;rez-Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2006080926"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "S274"
                        "paginaFinal" => "S280"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17130274"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S2215036614703293"
                          "estado" => "S300"
                          "issn" => "22150366"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations of the cytokine network in hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Tetta"
                            1 => "S&#46; David"
                            2 => "F&#46; Mariano"
                            3 => "C&#46; De Nitti"
                            4 => "V&#46; Panichi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "paginaInicial" => "S22"
                        "paginaFinal" => "S29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11798142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-10&#44; IL-6&#44; and TNF-a central factors in the altered cytokine network of uremia&#8212;the good&#44; the bad&#44; and the ugly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Stenvinkel"
                            1 => "M&#46; Ketteler"
                            2 => "R&#46;J&#46; Johnson"
                            3 => "B&#46; Lindholm"
                            4 => "R&#46; Pecoits-Filho"
                            5 => "M&#46; Riella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2005.00200.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2005"
                        "volumen" => "67"
                        "paginaInicial" => "1216"
                        "paginaFinal" => "1233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15780075"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CRP and acute renal rejection&#58; a marker to the point"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Roshdy"
                            1 => "M&#46;M&#46; El-Khatib"
                            2 => "M&#46;N&#46; Rizk"
                            3 => "A&#46;M&#46; El-Shehaby"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11255-011-0098-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Urol Nephrol"
                        "fecha" => "2012"
                        "volumen" => "44"
                        "paginaInicial" => "1251"
                        "paginaFinal" => "1255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22213063"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation-associated graft loss in renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;O&#46; Dahle"
                            1 => "G&#46; Mj&#248;en"
                            2 => "B&#46; Oqvist"
                            3 => "H&#46; Scharnagl"
                            4 => "G&#46; Weihrauch"
                            5 => "T&#46; Grammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr163"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "3756"
                        "paginaFinal" => "3761"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21511816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and atherosclerosis are associated with hypertension in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Azancot"
                            1 => "N&#46; Ramos"
                            2 => "I&#46;B&#46; Torres"
                            3 => "C&#46; Garc&#237;a-Carro"
                            4 => "K&#46; Romero"
                            5 => "E&#46; Espinel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Hypertens &#40;Greenwich&#41;"
                        "fecha" => "2015"
                        "volumen" => "17"
                        "paginaInicial" => "963"
                        "paginaFinal" => "969"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation&#44; coronary artery calcification and cardiovascular events in incident renal transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Roe"
                            1 => "M&#46; Wolfe"
                            2 => "M&#46; Joffe"
                            3 => "S&#46;E&#46; Rosas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2010.05.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2010"
                        "volumen" => "212"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20934074"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Abedini"
                            1 => "I&#46; Holme"
                            2 => "W&#46; M&#228;rz"
                            3 => "G&#46; Weihrauch"
                            4 => "B&#46; Fellstr&#246;m"
                            5 => "A&#46; Jardine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2215/CJN.00930209"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin J Am Soc Nephrol"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "1246"
                        "paginaFinal" => "1254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19541816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt&#47;beta-catenin activation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Mart&#237;nez-Moreno"
                            1 => "J&#46;R&#46; Mu&#241;oz-Casta&#241;eda"
                            2 => "C&#46; Herencia"
                            3 => "A&#46;M&#46; Oca"
                            4 => "J&#46;C&#46; Estepa"
                            5 => "R&#46; Canalejo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajprenal.00684.2011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Renal Physiol"
                        "fecha" => "2012"
                        "volumen" => "303"
                        "paginaInicial" => "F1136"
                        "paginaFinal" => "F1144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22874762"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kB signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Tan"
                            1 => "X&#46; Wen"
                            2 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2007060666"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "1741"
                        "paginaFinal" => "1752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18525004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "X&#46; Tan"
                            1 => "W&#46; He"
                            2 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2009.346"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2009"
                        "volumen" => "76"
                        "paginaInicial" => "1248"
                        "paginaFinal" => "1257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19759524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blockade of Wnt&#47;&#946;-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; He"
                            1 => "Y&#46;S&#46; Kang"
                            2 => "C&#46; Dai"
                            3 => "Y&#46; Liu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2009121236"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2011"
                        "volumen" => "22"
                        "paginaInicial" => "90"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21030600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of vitamin D derivates on vascular calcification associated to inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Guerrero"
                            1 => "A&#46; Montes de Oca"
                            2 => "E&#46; Aguilera-Tejero"
                            3 => "R&#46; Zafra"
                            4 => "M&#46; Rodr&#237;guez"
                            5 => "I&#46; L&#243;pez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfr555"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "2206"
                        "paginaFinal" => "2212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22025118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of oral paricalcitol on secondary hyperparathyroidism and proteinuria of kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Gonz&#225;lez"
                            1 => "J&#46; Rojas-Rivera"
                            2 => "N&#46; Polanco"
                            3 => "E&#46; Morales"
                            4 => "J&#46;M&#46; Morales"
                            5 => "J&#46; Egido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e3182855565"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2013"
                        "volumen" => "95"
                        "paginaInicial" => "e49"
                        "paginaFinal" => "e52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23545517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of paricalcitol on mineral bone metabolism in kidney transplant recipients with secondary hyperparathyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Borrego Utiel"
                            1 => "J&#46;A&#46; Bravo Soto"
                            2 => "M&#46;J&#46; Merino P&#233;rez"
                            3 => "I&#46; Gonz&#225;lez Carmelo"
                            4 => "V&#46; L&#243;pez Jim&#233;nez"
                            5 => "T&#46; Garc&#237;a &#193;lvarez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.nefro.2015.06.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2015"
                        "volumen" => "35"
                        "paginaInicial" => "363"
                        "paginaFinal" => "373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26306956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy&#58; results of the VITAL study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;W&#46; Coyne"
                            1 => "D&#46;L&#46; Andress"
                            2 => "M&#46;J&#46; Amdahl"
                            3 => "E&#46; Ritz"
                            4 => "E&#46; de Zeeuw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft227"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "2260"
                        "paginaFinal" => "2268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23787544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteinuria&#58; a new marker of long-term graft and patient survival in kidney transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Fern&#225;ndez-Fresnedo"
                            1 => "J&#46;J&#46; Plaza"
                            2 => "J&#46; S&#225;nchez-Plumed"
                            3 => "A&#46; Sanz-Guajardo"
                            4 => "R&#46; Palomar-Fontanet"
                            5 => "M&#46; Arias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "volumen" => "19"
                        "paginaInicial" => "47"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14671038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proteinuria after kidney transplantation&#44; relationship to allograft histology and survival"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Amer"
                            1 => "M&#46;E&#46; Fidler"
                            2 => "M&#46; Myslak"
                            3 => "P&#46; Morales"
                            4 => "W&#46;K&#46; Kremers"
                            5 => "T&#46;S&#46; Larson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-6143.2007.02006.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Transplant"
                        "fecha" => "2007"
                        "volumen" => "7"
                        "paginaInicial" => "2748"
                        "paginaFinal" => "2756"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17941956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-grade proteinuria and oligoalbuminuria in renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Halimi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e31828719fb"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2013"
                        "volumen" => "96"
                        "paginaInicial" => "121"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23435457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of renin&#8211;angiotensin gene expression in the kidney by paricalcitol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Freundlich"
                            1 => "Y&#46; Quiroz"
                            2 => "Z&#46; Zhang"
                            3 => "Y&#46; Zhang"
                            4 => "Y&#46; Bravo"
                            5 => "J&#46;R&#46; Weisinger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2008.408"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2008"
                        "volumen" => "74"
                        "paginaInicial" => "1394"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18813285"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vitamin D and proteinuria&#58; a critical review of molecular bases and clinical experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;V&#46; P&#233;rez-G&#243;mez"
                            1 => "A&#46; Ortiz-Ardu&#225;n"
                            2 => "V&#46; Lorenzo-Sellar&#233;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Apr.12025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "716"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24089164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonclassical aspects of differential vitamin D receptor activation&#58; implications for survival in patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Andress"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drugs"
                        "fecha" => "2007"
                        "volumen" => "67"
                        "paginaInicial" => "1999"
                        "paginaFinal" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17883284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pleiotropic actions of vitamin D"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Lin"
                            1 => "J&#46;H&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/bies.10368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioessays"
                        "fecha" => "2004"
                        "volumen" => "26"
                        "paginaInicial" => "21"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14696037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Beyond proteinuria&#58; VDR activation reduces renal inflammation in experimental diabetic nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;D&#46; Sanchez-Ni&#241;o"
                            1 => "M&#46; Bozic"
                            2 => "E&#46; C&#243;rdoba-Lanus"
                            3 => "P&#46; Valcheva"
                            4 => "O&#46; Gracia"
                            5 => "M&#46; Ibarz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol Renal Physiol"
                        "fecha" => "2011"
                        "volumen" => "302"
                        "paginaInicial" => "647"
                        "paginaFinal" => "657"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol attenuates 4-hydroxy-2-hexenal-induced inflammation and epithelial-mesenchymal transition in human renal proximal tubular epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;S&#46; Kim"
                            1 => "S&#46;Y&#46; Joo"
                            2 => "K&#46;E&#46; Lee"
                            3 => "J&#46;S&#46; Choi"
                            4 => "E&#46;H&#46; Bae"
                            5 => "S&#46;K&#46; Ma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "e63186"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces albuminuria and inflammation in chronic kidney disease&#58; a randomized double-blind pilot trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Alborzi"
                            1 => "N&#46;A&#46; Patel"
                            2 => "C&#46; Peterson"
                            3 => "J&#46;E&#46; Bills"
                            4 => "D&#46;M&#46; Bekele"
                            5 => "Z&#46; Bunaye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.108.113159"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2008"
                        "volumen" => "52"
                        "paginaInicial" => "249"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18606901"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Izquierdo"
                            1 => "M&#46; Cavia"
                            2 => "P&#46; Mu&#241;iz"
                            3 => "A&#46;L&#46; de Francisco"
                            4 => "M&#46; Arias"
                            5 => "J&#46; Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-13-159"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2012"
                        "volumen" => "13"
                        "paginaInicial" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23186077"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Selective vitamin D receptor activation as an anti-inflammatory target in chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Donate-Correa"
                            1 => "V&#46; Dom&#237;nguez-Pimentel"
                            2 => "M&#46;L&#46; M&#233;ndez-P&#233;rez"
                            3 => "M&#46; Muros-de-Fuentes"
                            4 => "C&#46; Mora-Fern&#225;ndez"
                            5 => "E&#46; Mart&#237;n-N&#250;&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/670475"
                      "Revista" => array:5 [
                        "tituloSerie" => "Mediators Inflamm"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "670475"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24511210"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anti-inflammatory profile of paricalcitol in hemodialysis patients&#58; a prospective&#44; open-label&#44; pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;F&#46; Navarro-Gonz&#225;lez"
                            1 => "J&#46; Donate-Correa"
                            2 => "M&#46;L&#46; M&#233;ndez"
                            3 => "M&#46; Muros de Fuentes"
                            4 => "J&#46; Garc&#237;a-P&#233;rez"
                            5 => "C&#46; Mora-Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jcph.19"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "2013"
                        "volumen" => "53"
                        "paginaInicial" => "421"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23426718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Paricalcitol reduces basal and lipopolysaccharide-induced &#40;LPS&#41; TNF-alpha and IL-8 production by human peripheral blood mononuclear cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Eleftheriadis"
                            1 => "G&#46; Antoniadi"
                            2 => "V&#46; Liakopoulos"
                            3 => "C&#46; Kartsios"
                            4 => "I&#46; Stefanidis"
                            5 => "G&#46; Galaktidou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11255-009-9541-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Urol Nephrol"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "181"
                        "paginaFinal" => "185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19259778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of paricalcitol in modulating the immune response in patients with renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Lucisano"
                            1 => "A&#46; Arena"
                            2 => "G&#46; Stassi"
                            3 => "D&#46; Iannello"
                            4 => "G&#46; Montalto"
                            5 => "A&#46; Romeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2015/765364"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Endocrinol"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "765364"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26451144"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Points to control in inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Nathan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature01320"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2002"
                        "volumen" => "420"
                        "paginaInicial" => "846"
                        "paginaFinal" => "852"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12490957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune and inflammatory mechanisms of atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Galkina"
                            1 => "K&#46; Ley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev.immunol.021908.132620"
                      "Revista" => array:6 [
                        "tituloSerie" => "Annu Rev Immunol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "165"
                        "paginaFinal" => "197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19302038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased IL-1beta IL-8&#44; and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Kostulas"
                            1 => "S&#46; Pelidou"
                            2 => "P&#46; Kivis&#228;kk"
                            3 => "V&#46; Kostulas"
                            4 => "H&#46; Link"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1999"
                        "volumen" => "30"
                        "paginaInicial" => "2174"
                        "paginaFinal" => "2179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10512924"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased mRNA expression of tumour necrosis factor-alpha and its converting enzyme in circulating leucocytes of patients with acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Akatsu"
                            1 => "M&#46; Nakamura"
                            2 => "M&#46; Satoh"
                            3 => "K&#46; Hiramori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/CS20020367"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "2003"
                        "volumen" => "105"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12605594"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Teng"
                            1 => "M&#46; Wolf"
                            2 => "E&#46; Lowrie"
                            3 => "N&#46; Ofsthun"
                            4 => "J&#46;M&#46; Lazarus"
                            5 => "R&#46; Thadhani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa022536"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "349"
                        "paginaInicial" => "446"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12890843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003700000006/v1_201712030528/S2013251417301943/v1_201712030528/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42660"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003700000006/v1_201712030528/S2013251417301943/v1_201712030528/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417301943?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 6 12
2024 October 40 39 79
2024 September 46 32 78
2024 August 82 74 156
2024 July 50 17 67
2024 June 65 33 98
2024 May 78 39 117
2024 April 55 35 90
2024 March 70 23 93
2024 February 66 39 105
2024 January 39 55 94
2023 December 39 40 79
2023 November 53 31 84
2023 October 59 54 113
2023 September 42 36 78
2023 August 47 30 77
2023 July 69 26 95
2023 June 52 24 76
2023 May 67 35 102
2023 April 25 11 36
2023 March 82 19 101
2023 February 37 24 61
2023 January 47 24 71
2022 December 70 24 94
2022 November 70 35 105
2022 October 81 44 125
2022 September 55 31 86
2022 August 53 49 102
2022 July 51 46 97
2022 June 42 38 80
2022 May 51 22 73
2022 April 52 43 95
2022 March 48 47 95
2022 February 81 35 116
2022 January 53 32 85
2021 December 46 38 84
2021 November 60 54 114
2021 October 55 40 95
2021 September 34 27 61
2021 August 56 42 98
2021 July 41 33 74
2021 June 45 25 70
2021 May 36 44 80
2021 April 113 65 178
2021 March 89 40 129
2021 February 90 31 121
2021 January 54 23 77
2020 December 39 18 57
2020 November 32 21 53
2020 October 28 18 46
2020 September 40 20 60
2020 August 47 13 60
2020 July 63 18 81
2020 June 36 24 60
2020 May 56 32 88
2020 April 36 13 49
2020 March 35 18 53
2020 February 122 19 141
2020 January 86 23 109
2019 December 96 26 122
2019 November 59 21 80
2019 October 29 14 43
2019 September 43 14 57
2019 August 21 11 32
2019 July 38 21 59
2019 June 36 27 63
2019 May 41 14 55
2019 April 69 23 92
2019 March 65 31 96
2019 February 40 28 68
2019 January 37 46 83
2018 December 72 34 106
2018 November 80 20 100
2018 October 52 18 70
2018 September 70 12 82
2018 August 46 17 63
2018 July 45 13 58
2018 June 51 9 60
2018 May 49 19 68
2018 April 52 8 60
2018 March 50 11 61
2018 February 34 5 39
2018 January 32 11 43
2017 December 53 14 67
2017 November 7 1 8
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?