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thrombocytopenia and acute kidney injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#8211;3</span></a> On rare occasions&#44; the thrombocytopenia may be transient and therefore undetected by laboratory tests&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> Because there is scarce information on the clinical characteristics of children with D&#43; HUS with no thrombocytopenia&#44; the aim of this study is to describe the clinical course of a series of patients with this particularity&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">We reviewed the medical records of all hospitalised children diagnosed with D&#43; HUS at the Pedro de Elizalde General Children&#39;s Hospital between 2000 and 2016 to identify those without thrombocytopenia&#46; Then&#44; the following variables were extracted from the medical records selected&#58; age&#44; gender&#44; time elapsed between the first symptom and diagnosis of D&#43; HUS&#44; signs and symptoms of the prodromal phase&#44; blood count on admission &#40;white blood cell and platelet counts&#44; haematocrit and haemoglobin&#41;&#44; minimum platelet count and the percentage of decrease in relation to the initial value&#44; maximum serum creatinine and severity of acute kidney injury&#44; number of red blood cell transfusions received&#44; need for and days of dialysis&#44; presence of severe extrarenal manifestations and&#47;or hypertension&#44; and isolation of the aetiological agent&#46; In addition&#44; follow-up time after the acute stage and renal status at the time of the last check-up was recorded&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The study was approved by our institution&#39;s research and ethics committees&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Definitions</span><p id="par0020" class="elsevierStylePara elsevierViewall">D&#43; HUS is defined as the presence of diarrhoea associated with thrombocytopenia &#40;&#60;150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#44; acute microangiopathic haemolytic anaemia &#40;haemoglobin &#60;3rd percentile for age and gender with the presence of schistocytes in a peripheral blood smear&#44; a negative Coombs&#8217; test and an increase in lactate dehydrogenase&#41; and kidney failure expressed by haematuria and proteinuria with or without elevated creatinine relative to ages&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#8211;3</span></a> Cases with no thrombocytopenia were considered to be when no test during hospitalisation showed a platelet count<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; but which met the rest of the criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> Platelet counts in all cases were determined by automated methods and later confirmed by paediatric haematologists at our hospital who directly viewed the peripheral blood smears&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The aetiological diagnosis was based on the identification of STEC or Shiga toxin in faeces and&#47;or positive antibodies to polysaccharides of the most common STEC serotypes&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> Given that Argentina not only has the highest global incidence of D&#43; HUS but also that the aetiological identification in our setting varies between 32&#37; and 54&#37;&#44; cases that showed a prodrome of diarrhoea&#44; even with no pathogen detected&#44; were also considered STEC-mediated&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">6&#44;7</span></a> Patients with familial or recurrent HUS and cases associated with specific causes&#44; such as deregulation of the complement system&#44; AIDS&#44; drugs and pneumococcal infection&#44; were excluded&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The presence of neurological manifestations&#44; such as decreased alertness&#44; seizures or coma&#44; and intestinal manifestations&#44; such as intussusception&#44; perforation or ischaemic colitis&#44; were considered to be serious extrarenal involvement&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Readings on the blood pressure monitor of systolic and&#47;or diastolic blood pressure greater than the 95th percentile for age&#44; height and gender according to the reference values were considered to be cases of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The indications for dialysis were anuria &#62;24<span class="elsevierStyleHsp" style=""></span>h&#44; untreatable electrolyte disturbances and hypervolaemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Creatinine was measured with the Jaffe reaction&#44; and glomerular filtration rate &#40;eGFR&#41; was estimated by the Schwartz formula&#44; using the maximum creatinine value&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a> The severity of the acute kidney injury was stratified according to paediatric RIFLE criteria <span class="elsevierStyleItalic">&#40;risk</span> decrease in eGFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>25&#37;&#59; <span class="elsevierStyleItalic">injury</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#59; and <span class="elsevierStyleItalic">failure</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>75&#37;&#41;&#44; assuming a baseline eGFR of 100<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> because&#44; as is usually the case with children with acute kidney injury&#44; the renal function before admission was not known&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Diuresis<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">17</span></a> was considered to be a normal urine output&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Haematuria was considered if there were more than 5 RBCs per field &#40;with &#215;400 magnification&#41; in centrifuged fresh urine&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Proteinuria was determined by means of a test strip&#59; the presence of 1&#43; or more on the colourimetric scale was considered a positive result&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">A descriptive analysis of the variables collected was performed&#59; continuous variables were expressed&#44; according to the distribution type &#40;Shapiro&#8211;Wilk test&#41;&#44; as the median &#40;interval&#41; or mean &#40;standard deviation&#41;&#44; and categorical variables were expressed as the frequency of distribution&#46; The statistical analysis was performed using Statistix&#44; ver&#46; 7 &#40;IBM version&#59; Analytical Software&#44; Tallahassee&#44; FL&#44; United States&#41;&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">From 2000 to 2016&#44; 161 children with D&#43; HUS were admitted to our hospital&#44; 9 of whom were identified with no thrombocytopenia &#40;prevalence of 5&#46;6&#37;&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The median age at diagnosis was 17 months &#40;7&#8211;32&#41;&#44; and the duration of the prodrome period was 15 days &#40;7&#8211;21&#41;&#46; Four patients showed no decrease in platelet count compared with the value on admission&#44; and the remaining 5 had a mean decrease of 30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#37;&#59; but all had values greater than 150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> throughout hospitalisation&#46; The median number of red blood cell transfusions was 1 &#40;0&#8211;2&#41;&#44; and no patient had severe extrarenal involvement and&#47;or hypertension&#46; Regarding the severity of kidney failure based on the paediatric RIFLE criteria&#44; in 3 cases there was no acute kidney injury &#40;although haematuria and proteinuria were present as a sign of kidney disease&#41;&#44; 2 cases fell under the <span class="elsevierStyleItalic">risk</span> category&#44; 2 under <span class="elsevierStyleItalic">injury</span> and 2 under <span class="elsevierStyleItalic">failure</span>&#46; Eight patients had normal diuresis and one young girl had anuria and severe kidney failure &#40;creatinine 8&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl on admission&#41; and required peritoneal dialysis&#46; She had no history of kidney disease nor had she received drugs during the prodromal phase&#59; her C3 &#40;89<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and C4 &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; levels were normal&#44; and no bacterial or viral agents were detected in her blood&#46; Likewise&#44; the test for Shiga toxin and the faecal culture were negative&#46; An ultrasound revealed normal-sized hyperechogenic kidneys&#46; Given the absence of thrombocytopenia&#44; together with the severity of the kidney failure and the lack of aetiological identification&#44; a kidney biopsy was performed that confirmed the diagnosis of thrombotic microangiopathy&#46; The main findings from the biopsy were as follows&#58; thickening and disruption of the glomerular capillary walls&#59; focal mesangiolysis and aneurysmal dilatation of the glomerular capillaries&#59; patchy acute tubular necrosis&#59; and interstitial oedema involving less than 5&#37; of the sample&#46; The arteries and arterioles showed no changes&#46; Fibrin thrombi were identified by immunofluorescence &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; She needed 7 days of dialysis and 2 red blood cell transfusions during hospitalisation&#44; and was discharged in good clinical condition and with her kidney function improving progressively &#40;creatinine 1&#46;19<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; During the outpatient follow-up&#44; she had a positive result for polysaccharide antibodies to <span class="elsevierStyleItalic">Escherichia coli</span> O145&#44; and her kidney function was stabilised &#40;creatinine 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the patients&#8217; demographic and clinical characteristics&#44; and <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the laboratory findings during the acute phase&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">After discharge&#44; the patients were followed for 2 years &#40;1&#46;5&#8211;4&#41;&#44; and all had a normal eGFR&#44; no proteinuria or haematuria and normal blood pressure&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">The presence of thrombocytopenia is a distinctive sign of D&#43; HUS&#59; however&#44; it may be transient and therefore go undetected&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> There is limited information on the prevalence of D&#43; HUS with no thrombocytopenia&#44; and the course of the disease in these patients has not been described in detail&#46; In a cohort of 102 patients with D&#43; HUS&#44; Schifferli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">19</span></a> found that 7 &#40;6&#46;8&#37;&#41; had no thrombocytopenia&#44; a prevalence similar to that seen by Siegler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> &#40;6&#37;&#41; in 157 cases &#40;89&#37; with prodrome of diarrhoea&#41;&#46; Similarly&#44; in our series of 161 children&#44; the prevalence of lack of thrombocytopenia was 5&#46;6&#37;&#46; These results differed from those seen by Gim&#233;nez Llort et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a> who noted a lower prevalence &#40;one case in 51 children&#44; or 2&#37;&#41;&#44; and from that reported by Ardissino et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">22</span></a> who found this condition in 11&#37; of their cases&#59; although it should be clarified here that in the latter study&#44; this percentage corresponds to patients with platelet counts<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> on admission&#44; but this does not specify whether they later declined during the course of the disease&#46; Finally&#44; in Argentina&#44; in 254 children with bloody diarrhoea&#44; L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> found that 6 developed HUS and 14 had &#8220;incomplete forms&#8221; &#40;they did not meet 3 diagnostic criteria&#41;&#44; with 3 showing no thrombocytopenia&#44; i&#46;e&#46; the missing criterion&#46; The case reported by Meier et al&#46; is interesting&#59; it concerns a child with diarrhoea due to STEC&#44; who developed microangiopathic anaemia with no kidney impairment or thrombocytopenia&#46; The authors speculated that Shiga toxin may cause direct damage to the erythrocyte membrane as a possible explanation for such a case&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">23</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this is the first case-series to specifically describe the disease&#39;s course in patients with D&#43; HUS with no thrombocytopenia&#46; The median age of the group studied &#40;17 months&#41; is consistent with that of children who meet all the diagnostic criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> It should be noted that the median time between the first symptom and the diagnosis &#40;15 days&#41; was longer than usual &#40;the median is approximately 7 days&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Late diagnosis may explain the absence of thrombocytopenia&#59; it is possible that the children studied here presented with transient thrombocytopenia&#44; but that at the time of the laboratory tests the rebound of the platelet count was detected&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Moreover&#44; no patients showed a decrease of less than 150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; nor were there sudden reductions in platelet counts compared with the baseline values &#40;the mean decrease was 30&#37;&#41;&#46; Late diagnosis may also have been responsible for the low rate of isolation of STEC in stools in our patients&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> which was only possible in 3 of 9 cases&#44; although the isolation rate is within the norm in our setting&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In D&#43; HUS&#44; platelet counts are commonly normalised before kidney function is recovered&#59; in fact&#44; the time to reaching a count<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> was proposed as an indirect marker that the microangiopathic process has resolved&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a> Accordingly&#44; it has been postulated that these late cases with no thrombocytopenia are usually mild&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Our results confirm this assumption&#58; no patient presented with serious extrarenal involvement&#44; and&#44; although the severity of acute kidney injury varied&#44; 8 of 9 cases maintained adequate diuresis with no need for dialysis&#44; i&#46;e&#46; a lower rate than previously reported in children with D&#43; HUS&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">13&#44;14&#44;25</span></a> In addition&#44; no patient had any signs of renal sequelae at the last check-up&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In conclusion&#44; the prevalence of D&#43; HUS with no thrombocytopenia was 5&#46;6&#37; and most cases were mild&#59; however&#44; since one patient required dialysis&#44; it is worth noting that the normalisation of platelet counts is not always an accurate marker that the disease has resolved&#46; Additionally&#44; our results show that the time when D&#43; HUS cases present with normal platelet counts is usually long after the first intestinal symptoms&#44; and a high rate of diagnostic suspicion is therefore necessary&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have no potential conflicts of interest related to the contents of this article&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Thrombocytopenia is a hallmark of postdiarrhoeal haemolytic uraemic syndrome &#40;D&#43; HUS&#41;&#44; although it can be transient and therefore undetected&#46; There is scarce information regarding the prevalence and the course of the disease in children with D&#43; HUS without thrombocytopenia&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of D&#43; HUS without thrombocytopenia and to describe the clinical characteristics of a series of children with this condition&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The medical records of patients with D&#43; HUS hospitalised between 2000 and 2016 were reviewed to identify those without thrombocytopenia &#40;&#62;150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#46; Demographic&#44; clinical and laboratory parameters of the selected cases were collected and descriptively analysed&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nine cases &#40;5&#46;6&#37;&#41; without thrombocytopenia were identified among 161 patients hospitalised during the study period&#46; Median age at diagnosis was 17 months &#40;7&#8211;32&#41; and median prodromal symptom duration was 15 days &#40;7&#8211;21&#41;&#46; Eight patients maintained normal urine output while the remaining one required dialysis&#46; No patient presented with severe extrarenal compromise and&#47;or hypertension&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The prevalence of non-thrombocytopenic D&#43; HUS was 5&#46;6&#37; and most cases occurred with mild forms of the disease&#59; however&#44; the need for dialysis in one of them indicated that normalisation of platelet count is not always an accurate marker for disease remittance&#46; Our results also confirm that the time of onset of D&#43; HUS in patients without thrombocytopenia is usually delayed with respect to the initial intestinal symptoms&#59; thus&#44; heightened diagnostic suspicion is necessary&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La presencia de trombocitopenia es una marca distintiva del s&#237;ndrome ur&#233;mico hemol&#237;tico asociado a diarrea &#40;SUH D&#43;&#41;&#59; sin embargo&#44; puede ser transitoria y&#44; por lo tanto&#44; no ser detectada&#46; Existe limitada informaci&#243;n sobre la prevalencia y el curso de la enfermedad en ni&#241;os con SUH D&#43; sin trombocitopenia&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de SUH D&#43; sin trombocitopenia y describir las caracter&#237;sticas cl&#237;nicas de una serie de ni&#241;os con esta particularidad&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pacientes y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Fueron revisadas las historias cl&#237;nicas de los pacientes con SUH D&#43; internados entre 2000 y 2016 para identificar a aquellos sin trombocitopenia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>150&#46;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#46; De los casos seleccionados se recolectaron las variables demogr&#225;ficas&#44; cl&#237;nicas y de laboratorio&#44; las cuales fueron analizadas descriptivamente&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">De 161 pacientes internados durante el periodo de estudio se identificaron 9 sin trombocitopenia &#40;5&#44;6&#37;&#41;&#46; La mediana de la edad al diagn&#243;stico fue de 17 meses &#40;7-32&#41; y la de la duraci&#243;n del periodo prodr&#243;mico&#44; de 15 d&#237;as &#40;7-21&#41;&#46; Ocho pacientes mantuvieron diuresis normal y uno requiri&#243; di&#225;lisis&#46; Ning&#250;n paciente present&#243; compromiso extrarrenal severo y&#47;o hipertensi&#243;n arterial&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de SUH D&#43; sin trombocitopenia fue del 5&#44;6&#37; y la mayor&#237;a de los casos fueron leves&#59; sin embargo&#44; el requerimiento de di&#225;lisis en uno de ellos se&#241;ala que la normalizaci&#243;n del recuento de plaquetas no siempre es un marcador preciso de resoluci&#243;n de la enfermedad&#46; Nuestros resultados tambi&#233;n confirman que el momento de presentaci&#243;n de los pacientes con SUH D&#43; sin trombocitopenia est&#225; usualmente alejado de los primeros s&#237;ntomas intestinales&#44; por lo que es necesario un alto &#237;ndice de sospecha diagn&#243;stica&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Antecedentes"
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          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
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          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Pacientes y m&#233;todos"
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          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
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    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Balestracci A&#44; Toledo I&#44; Meni Battaglia L&#44; de Lillo L&#44; More N&#44; Cao G&#44; et al&#46; S&#237;ndrome ur&#233;mico hemol&#237;tico asociado a diarrea sin trombocitopenia&#46; Nefrologia&#46; 2017&#59;37&#58;508&#8211;514&#46;</p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Findings from the renal histology of one child with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46; &#40;A&#41; Renal glomeruli with capillary dilatation and mesangiolysis &#40;white arrow&#41;&#46; Haematoxylin and eosin&#44; 400&#215;&#46; &#40;B&#41; Immunofluorescence showed fibrin thrombi in some glomeruli &#40;white arrow&#41;&#44; 400&#215;&#46;</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">F&#58; female&#59; M&#58; male&#59; BP&#58; blood pressure&#59; RBCT&#58; red blood cell transfusion&#59; Stx&#58; Shiga toxin&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Gender &#40;F&#47;M&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Duration of prodromal phase &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms of prodromal phase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RBCT &#40;number&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Dialysis &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Serious extrarenal involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Maximum BP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Aetiology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span> O157&#58;H7 and Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Vomiting&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span> O157&#58;H7 and Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdominal pain<br>Diarrhoea with no blood<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Polysaccharide antibodies to <span class="elsevierStyleItalic">Escherichia coli</span> O145&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Demographic and clinical characteristics of children with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46;</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">eGFR&#58; estimated glomerular filtration rate&#59; WBC&#58; white blood cells&#59; Hb&#58; haemoglobin&#59; Ht&#58; haematocrit&#59; LDH&#58; lactate dehydrogenase&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Ht &#40;&#37;&#41; on admission&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">374&#44;000&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1180&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">153&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1845&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Laboratory parameters during the acute period in children with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46;</p>"
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      ]
    ]
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
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            0 => array:3 [
              "identificador" => "bib0130"
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                    0 => array:2 [
                      "titulo" => "Clinical practice&#46; Today&#39;s understanding of the haemolytic uraemic syndrome"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Scheiring"
                            1 => "A&#46; Rosales"
                            2 => "L&#46;B&#46; Zimmerhackl"
                          ]
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1007/s00431-009-1039-4"
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                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "2010"
                        "volumen" => "169"
                        "paginaInicial" => "7"
                        "paginaFinal" => "13"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19707787"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome &#40;HUS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "S&#46;P&#46; Andreoli"
                            2 => "L&#46;B&#46; Zimmerhackl"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1007/s00467-008-0935-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Nephrol"
                        "fecha" => "2008"
                        "volumen" => "23"
                        "paginaInicial" => "1749"
                        "paginaFinal" => "1760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18704506"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0140"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "EHEC-0025-2014"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shiga toxin&#47;verocytotoxin-producing <span class="elsevierStyleItalic">Escherichia coli</span> infections&#58; practical clinical perspectives"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "T&#46;K&#46; Davis"
                            1 => "N&#46;C&#46; van de Kar"
                            2 => "P&#46;I&#46; Tarr"
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                        ]
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Microbiol Spectr"
                        "fecha" => "2014"
                        "volumen" => "2"
                      ]
                    ]
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            3 => array:3 [
              "identificador" => "bib0145"
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Original article
Postdiarrhoeal haemolytic uraemic syndrome without thrombocytopenia
Síndrome urémico hemolítico asociado a diarrea sin trombocitopenia
Alejandro Balestraccia,
Corresponding author
abalestracci@yahoo.com.ar

Corresponding author.
, Ismael Toledoa, Luciana Meni Battagliaa, Leonardo de Lillob, Natalia Moreb, Gabriel Caoc, Caupolican Alvaradoa
a Unidad de Nefrología, Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina
b Departamento de Pediatría, Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina
c División de Patología, Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina
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        "titulo" => "S&#237;ndrome ur&#233;mico hemol&#237;tico asociado a diarrea sin trombocitopenia"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Findings from the renal histology of one child with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46; &#40;A&#41; Renal glomeruli with capillary dilatation and mesangiolysis &#40;white arrow&#41;&#46; Haematoxylin and eosin&#44; 400&#215;&#46; &#40;B&#41; Immunofluorescence showed fibrin thrombi in some glomeruli &#40;white arrow&#41;&#44; 400&#215;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Diarrhoea-positive haemolytic uraemic syndrome &#40;D&#43; HUS&#41; is one of the main causes of acute kidney injury in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#44;2</span></a> It is mediated by Shiga toxin-producing <span class="elsevierStyleItalic">Escherichia coli</span> &#40;STEC&#41;&#44; which causes direct endothelial damage inducing platelet aggregation and thrombus formation that occlude the microvasculature of vital organs such as the kidneys&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#44;2</span></a> The diagnosis of D&#43; HUS is based on the presence of a prodrome of diarrhoea associated with microangiopathic haemolytic anaemia&#44; thrombocytopenia and acute kidney injury&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#8211;3</span></a> On rare occasions&#44; the thrombocytopenia may be transient and therefore undetected by laboratory tests&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> Because there is scarce information on the clinical characteristics of children with D&#43; HUS with no thrombocytopenia&#44; the aim of this study is to describe the clinical course of a series of patients with this particularity&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">We reviewed the medical records of all hospitalised children diagnosed with D&#43; HUS at the Pedro de Elizalde General Children&#39;s Hospital between 2000 and 2016 to identify those without thrombocytopenia&#46; Then&#44; the following variables were extracted from the medical records selected&#58; age&#44; gender&#44; time elapsed between the first symptom and diagnosis of D&#43; HUS&#44; signs and symptoms of the prodromal phase&#44; blood count on admission &#40;white blood cell and platelet counts&#44; haematocrit and haemoglobin&#41;&#44; minimum platelet count and the percentage of decrease in relation to the initial value&#44; maximum serum creatinine and severity of acute kidney injury&#44; number of red blood cell transfusions received&#44; need for and days of dialysis&#44; presence of severe extrarenal manifestations and&#47;or hypertension&#44; and isolation of the aetiological agent&#46; In addition&#44; follow-up time after the acute stage and renal status at the time of the last check-up was recorded&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The study was approved by our institution&#39;s research and ethics committees&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Definitions</span><p id="par0020" class="elsevierStylePara elsevierViewall">D&#43; HUS is defined as the presence of diarrhoea associated with thrombocytopenia &#40;&#60;150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#44; acute microangiopathic haemolytic anaemia &#40;haemoglobin &#60;3rd percentile for age and gender with the presence of schistocytes in a peripheral blood smear&#44; a negative Coombs&#8217; test and an increase in lactate dehydrogenase&#41; and kidney failure expressed by haematuria and proteinuria with or without elevated creatinine relative to ages&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">1&#8211;3</span></a> Cases with no thrombocytopenia were considered to be when no test during hospitalisation showed a platelet count<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; but which met the rest of the criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> Platelet counts in all cases were determined by automated methods and later confirmed by paediatric haematologists at our hospital who directly viewed the peripheral blood smears&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The aetiological diagnosis was based on the identification of STEC or Shiga toxin in faeces and&#47;or positive antibodies to polysaccharides of the most common STEC serotypes&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> Given that Argentina not only has the highest global incidence of D&#43; HUS but also that the aetiological identification in our setting varies between 32&#37; and 54&#37;&#44; cases that showed a prodrome of diarrhoea&#44; even with no pathogen detected&#44; were also considered STEC-mediated&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">6&#44;7</span></a> Patients with familial or recurrent HUS and cases associated with specific causes&#44; such as deregulation of the complement system&#44; AIDS&#44; drugs and pneumococcal infection&#44; were excluded&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The presence of neurological manifestations&#44; such as decreased alertness&#44; seizures or coma&#44; and intestinal manifestations&#44; such as intussusception&#44; perforation or ischaemic colitis&#44; were considered to be serious extrarenal involvement&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Readings on the blood pressure monitor of systolic and&#47;or diastolic blood pressure greater than the 95th percentile for age&#44; height and gender according to the reference values were considered to be cases of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The indications for dialysis were anuria &#62;24<span class="elsevierStyleHsp" style=""></span>h&#44; untreatable electrolyte disturbances and hypervolaemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Creatinine was measured with the Jaffe reaction&#44; and glomerular filtration rate &#40;eGFR&#41; was estimated by the Schwartz formula&#44; using the maximum creatinine value&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a> The severity of the acute kidney injury was stratified according to paediatric RIFLE criteria <span class="elsevierStyleItalic">&#40;risk</span> decrease in eGFR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>25&#37;&#59; <span class="elsevierStyleItalic">injury</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50&#37;&#59; and <span class="elsevierStyleItalic">failure</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>75&#37;&#41;&#44; assuming a baseline eGFR of 100<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> because&#44; as is usually the case with children with acute kidney injury&#44; the renal function before admission was not known&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Diuresis<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>ml&#47;kg&#47;h<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">17</span></a> was considered to be a normal urine output&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Haematuria was considered if there were more than 5 RBCs per field &#40;with &#215;400 magnification&#41; in centrifuged fresh urine&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Proteinuria was determined by means of a test strip&#59; the presence of 1&#43; or more on the colourimetric scale was considered a positive result&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">A descriptive analysis of the variables collected was performed&#59; continuous variables were expressed&#44; according to the distribution type &#40;Shapiro&#8211;Wilk test&#41;&#44; as the median &#40;interval&#41; or mean &#40;standard deviation&#41;&#44; and categorical variables were expressed as the frequency of distribution&#46; The statistical analysis was performed using Statistix&#44; ver&#46; 7 &#40;IBM version&#59; Analytical Software&#44; Tallahassee&#44; FL&#44; United States&#41;&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">From 2000 to 2016&#44; 161 children with D&#43; HUS were admitted to our hospital&#44; 9 of whom were identified with no thrombocytopenia &#40;prevalence of 5&#46;6&#37;&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The median age at diagnosis was 17 months &#40;7&#8211;32&#41;&#44; and the duration of the prodrome period was 15 days &#40;7&#8211;21&#41;&#46; Four patients showed no decrease in platelet count compared with the value on admission&#44; and the remaining 5 had a mean decrease of 30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#37;&#59; but all had values greater than 150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> throughout hospitalisation&#46; The median number of red blood cell transfusions was 1 &#40;0&#8211;2&#41;&#44; and no patient had severe extrarenal involvement and&#47;or hypertension&#46; Regarding the severity of kidney failure based on the paediatric RIFLE criteria&#44; in 3 cases there was no acute kidney injury &#40;although haematuria and proteinuria were present as a sign of kidney disease&#41;&#44; 2 cases fell under the <span class="elsevierStyleItalic">risk</span> category&#44; 2 under <span class="elsevierStyleItalic">injury</span> and 2 under <span class="elsevierStyleItalic">failure</span>&#46; Eight patients had normal diuresis and one young girl had anuria and severe kidney failure &#40;creatinine 8&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dl on admission&#41; and required peritoneal dialysis&#46; She had no history of kidney disease nor had she received drugs during the prodromal phase&#59; her C3 &#40;89<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and C4 &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; levels were normal&#44; and no bacterial or viral agents were detected in her blood&#46; Likewise&#44; the test for Shiga toxin and the faecal culture were negative&#46; An ultrasound revealed normal-sized hyperechogenic kidneys&#46; Given the absence of thrombocytopenia&#44; together with the severity of the kidney failure and the lack of aetiological identification&#44; a kidney biopsy was performed that confirmed the diagnosis of thrombotic microangiopathy&#46; The main findings from the biopsy were as follows&#58; thickening and disruption of the glomerular capillary walls&#59; focal mesangiolysis and aneurysmal dilatation of the glomerular capillaries&#59; patchy acute tubular necrosis&#59; and interstitial oedema involving less than 5&#37; of the sample&#46; The arteries and arterioles showed no changes&#46; Fibrin thrombi were identified by immunofluorescence &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; She needed 7 days of dialysis and 2 red blood cell transfusions during hospitalisation&#44; and was discharged in good clinical condition and with her kidney function improving progressively &#40;creatinine 1&#46;19<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; During the outpatient follow-up&#44; she had a positive result for polysaccharide antibodies to <span class="elsevierStyleItalic">Escherichia coli</span> O145&#44; and her kidney function was stabilised &#40;creatinine 0&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the patients&#8217; demographic and clinical characteristics&#44; and <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the laboratory findings during the acute phase&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">After discharge&#44; the patients were followed for 2 years &#40;1&#46;5&#8211;4&#41;&#44; and all had a normal eGFR&#44; no proteinuria or haematuria and normal blood pressure&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">The presence of thrombocytopenia is a distinctive sign of D&#43; HUS&#59; however&#44; it may be transient and therefore go undetected&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">4</span></a> There is limited information on the prevalence of D&#43; HUS with no thrombocytopenia&#44; and the course of the disease in these patients has not been described in detail&#46; In a cohort of 102 patients with D&#43; HUS&#44; Schifferli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">19</span></a> found that 7 &#40;6&#46;8&#37;&#41; had no thrombocytopenia&#44; a prevalence similar to that seen by Siegler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a> &#40;6&#37;&#41; in 157 cases &#40;89&#37; with prodrome of diarrhoea&#41;&#46; Similarly&#44; in our series of 161 children&#44; the prevalence of lack of thrombocytopenia was 5&#46;6&#37;&#46; These results differed from those seen by Gim&#233;nez Llort et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a> who noted a lower prevalence &#40;one case in 51 children&#44; or 2&#37;&#41;&#44; and from that reported by Ardissino et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">22</span></a> who found this condition in 11&#37; of their cases&#59; although it should be clarified here that in the latter study&#44; this percentage corresponds to patients with platelet counts<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> on admission&#44; but this does not specify whether they later declined during the course of the disease&#46; Finally&#44; in Argentina&#44; in 254 children with bloody diarrhoea&#44; L&#243;pez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">5</span></a> found that 6 developed HUS and 14 had &#8220;incomplete forms&#8221; &#40;they did not meet 3 diagnostic criteria&#41;&#44; with 3 showing no thrombocytopenia&#44; i&#46;e&#46; the missing criterion&#46; The case reported by Meier et al&#46; is interesting&#59; it concerns a child with diarrhoea due to STEC&#44; who developed microangiopathic anaemia with no kidney impairment or thrombocytopenia&#46; The authors speculated that Shiga toxin may cause direct damage to the erythrocyte membrane as a possible explanation for such a case&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">23</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this is the first case-series to specifically describe the disease&#39;s course in patients with D&#43; HUS with no thrombocytopenia&#46; The median age of the group studied &#40;17 months&#41; is consistent with that of children who meet all the diagnostic criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">6</span></a> It should be noted that the median time between the first symptom and the diagnosis &#40;15 days&#41; was longer than usual &#40;the median is approximately 7 days&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Late diagnosis may explain the absence of thrombocytopenia&#59; it is possible that the children studied here presented with transient thrombocytopenia&#44; but that at the time of the laboratory tests the rebound of the platelet count was detected&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Moreover&#44; no patients showed a decrease of less than 150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#44; nor were there sudden reductions in platelet counts compared with the baseline values &#40;the mean decrease was 30&#37;&#41;&#46; Late diagnosis may also have been responsible for the low rate of isolation of STEC in stools in our patients&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">3</span></a> which was only possible in 3 of 9 cases&#44; although the isolation rate is within the norm in our setting&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In D&#43; HUS&#44; platelet counts are commonly normalised before kidney function is recovered&#59; in fact&#44; the time to reaching a count<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span> was proposed as an indirect marker that the microangiopathic process has resolved&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">8</span></a> Accordingly&#44; it has been postulated that these late cases with no thrombocytopenia are usually mild&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> Our results confirm this assumption&#58; no patient presented with serious extrarenal involvement&#44; and&#44; although the severity of acute kidney injury varied&#44; 8 of 9 cases maintained adequate diuresis with no need for dialysis&#44; i&#46;e&#46; a lower rate than previously reported in children with D&#43; HUS&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">13&#44;14&#44;25</span></a> In addition&#44; no patient had any signs of renal sequelae at the last check-up&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In conclusion&#44; the prevalence of D&#43; HUS with no thrombocytopenia was 5&#46;6&#37; and most cases were mild&#59; however&#44; since one patient required dialysis&#44; it is worth noting that the normalisation of platelet counts is not always an accurate marker that the disease has resolved&#46; Additionally&#44; our results show that the time when D&#43; HUS cases present with normal platelet counts is usually long after the first intestinal symptoms&#44; and a high rate of diagnostic suspicion is therefore necessary&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that they have no potential conflicts of interest related to the contents of this article&#46;</p></span></span>"
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            0 => "S&#237;ndrome ur&#233;mico hemol&#237;tico"
            1 => "Atrombocitopenia"
            2 => "<span class="elsevierStyleItalic">Escherichia coli</span>"
            3 => "Ni&#241;os"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Thrombocytopenia is a hallmark of postdiarrhoeal haemolytic uraemic syndrome &#40;D&#43; HUS&#41;&#44; although it can be transient and therefore undetected&#46; There is scarce information regarding the prevalence and the course of the disease in children with D&#43; HUS without thrombocytopenia&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of D&#43; HUS without thrombocytopenia and to describe the clinical characteristics of a series of children with this condition&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The medical records of patients with D&#43; HUS hospitalised between 2000 and 2016 were reviewed to identify those without thrombocytopenia &#40;&#62;150&#44;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#46; Demographic&#44; clinical and laboratory parameters of the selected cases were collected and descriptively analysed&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nine cases &#40;5&#46;6&#37;&#41; without thrombocytopenia were identified among 161 patients hospitalised during the study period&#46; Median age at diagnosis was 17 months &#40;7&#8211;32&#41; and median prodromal symptom duration was 15 days &#40;7&#8211;21&#41;&#46; Eight patients maintained normal urine output while the remaining one required dialysis&#46; No patient presented with severe extrarenal compromise and&#47;or hypertension&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The prevalence of non-thrombocytopenic D&#43; HUS was 5&#46;6&#37; and most cases occurred with mild forms of the disease&#59; however&#44; the need for dialysis in one of them indicated that normalisation of platelet count is not always an accurate marker for disease remittance&#46; Our results also confirm that the time of onset of D&#43; HUS in patients without thrombocytopenia is usually delayed with respect to the initial intestinal symptoms&#59; thus&#44; heightened diagnostic suspicion is necessary&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Patients and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La presencia de trombocitopenia es una marca distintiva del s&#237;ndrome ur&#233;mico hemol&#237;tico asociado a diarrea &#40;SUH D&#43;&#41;&#59; sin embargo&#44; puede ser transitoria y&#44; por lo tanto&#44; no ser detectada&#46; Existe limitada informaci&#243;n sobre la prevalencia y el curso de la enfermedad en ni&#241;os con SUH D&#43; sin trombocitopenia&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de SUH D&#43; sin trombocitopenia y describir las caracter&#237;sticas cl&#237;nicas de una serie de ni&#241;os con esta particularidad&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pacientes y m&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Fueron revisadas las historias cl&#237;nicas de los pacientes con SUH D&#43; internados entre 2000 y 2016 para identificar a aquellos sin trombocitopenia &#40;&#62;<span class="elsevierStyleHsp" style=""></span>150&#46;000<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#41;&#46; De los casos seleccionados se recolectaron las variables demogr&#225;ficas&#44; cl&#237;nicas y de laboratorio&#44; las cuales fueron analizadas descriptivamente&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">De 161 pacientes internados durante el periodo de estudio se identificaron 9 sin trombocitopenia &#40;5&#44;6&#37;&#41;&#46; La mediana de la edad al diagn&#243;stico fue de 17 meses &#40;7-32&#41; y la de la duraci&#243;n del periodo prodr&#243;mico&#44; de 15 d&#237;as &#40;7-21&#41;&#46; Ocho pacientes mantuvieron diuresis normal y uno requiri&#243; di&#225;lisis&#46; Ning&#250;n paciente present&#243; compromiso extrarrenal severo y&#47;o hipertensi&#243;n arterial&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de SUH D&#43; sin trombocitopenia fue del 5&#44;6&#37; y la mayor&#237;a de los casos fueron leves&#59; sin embargo&#44; el requerimiento de di&#225;lisis en uno de ellos se&#241;ala que la normalizaci&#243;n del recuento de plaquetas no siempre es un marcador preciso de resoluci&#243;n de la enfermedad&#46; Nuestros resultados tambi&#233;n confirman que el momento de presentaci&#243;n de los pacientes con SUH D&#43; sin trombocitopenia est&#225; usualmente alejado de los primeros s&#237;ntomas intestinales&#44; por lo que es necesario un alto &#237;ndice de sospecha diagn&#243;stica&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Pacientes y m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Balestracci A&#44; Toledo I&#44; Meni Battaglia L&#44; de Lillo L&#44; More N&#44; Cao G&#44; et al&#46; S&#237;ndrome ur&#233;mico hemol&#237;tico asociado a diarrea sin trombocitopenia&#46; Nefrologia&#46; 2017&#59;37&#58;508&#8211;514&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1634
            "Ancho" => 1155
            "Tamanyo" => 319872
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Findings from the renal histology of one child with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46; &#40;A&#41; Renal glomeruli with capillary dilatation and mesangiolysis &#40;white arrow&#41;&#46; Haematoxylin and eosin&#44; 400&#215;&#46; &#40;B&#41; Immunofluorescence showed fibrin thrombi in some glomeruli &#40;white arrow&#41;&#44; 400&#215;&#46;</p>"
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      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">F&#58; female&#59; M&#58; male&#59; BP&#58; blood pressure&#59; RBCT&#58; red blood cell transfusion&#59; Stx&#58; Shiga toxin&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Gender &#40;F&#47;M&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Duration of prodromal phase &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms of prodromal phase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">RBCT &#40;number&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Dialysis &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Serious extrarenal involvement&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Maximum BP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Aetiology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span> O157&#58;H7 and Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Vomiting&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">95&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span> O157&#58;H7 and Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Abdominal pain<br>Diarrhoea with no blood<br>Fever<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Stx2 in stools&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diarrhoea with no blood<br>Pallor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Polysaccharide antibodies to <span class="elsevierStyleItalic">Escherichia coli</span> O145&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bloody diarrhoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#47;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Demographic and clinical characteristics of children with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46;</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">eGFR&#58; estimated glomerular filtration rate&#59; WBC&#58; white blood cells&#59; Hb&#58; haemoglobin&#59; Ht&#58; haematocrit&#59; LDH&#58; lactate dehydrogenase&#46;</p>"
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Proteinuria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Red blood cells in urine&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Ht &#40;&#37;&#41; on admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hb &#40;g&#47;dl&#41; on admission&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Minimum platelet count &#40;m<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Maximum LDH &#40;IU&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Maximum creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6900&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#8211;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">374&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">374&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#44;800&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">199&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">153&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1845&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">435&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">388&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#44;200&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">374&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">278&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1460&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#8211;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;300&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">570&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">360&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1494&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Laboratory parameters during the acute period in children with diarrhoea-positive haemolytic uraemic syndrome with no thrombocytopenia&#46;</p>"
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    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice&#46; Today&#39;s understanding of the haemolytic uraemic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Scheiring"
                            1 => "A&#46; Rosales"
                            2 => "L&#46;B&#46; Zimmerhackl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00431-009-1039-4"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "2010"
                        "volumen" => "169"
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Article information
ISSN: 20132514
Original language: English
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