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        "titulo" => "Enfermedad renal cr&#243;nica en individuos hipertensos &#8805;60 a&#241;os atendidos en Atenci&#243;n Primaria"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estimation&#44; based on the logistic regression model&#44; of the probability of subjects included in the sample of hypertensive individuals aged &#8805;60 years&#44; taken from the <span class="elsevierStyleItalic">SIDIAP plus</span> database as of 1st January 2011&#44; being in the glomerular filtration rate &#60;60 group&#44; according to age and gender &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&#41;&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estimates for non-smokers with albumin&#47;creatinine ratio &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; without dyslipidaemia&#44; obesity&#44; atrial fibrillation&#44; heart failure or diabetes&#44; living in an urban environment and in the central quintile of the MEDEA socioeconomic level&#46; For any other individual profile&#44; the expected probabilities according to the logistic regression model differ from those shown&#46; However&#44; the effect of the age-gender correlation shown is maintained&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic kidney disease &#40;CKD&#41;&#44; defined as a reduction of the estimated glomerular filtration rate &#40;eGFR&#41; below 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> or the presence of kidney damage&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> is associated with an increased risk of cardiovascular morbidity and mortality and progression to end-stage renal disease &#40;ESRD&#41; in both the general population and in hypertensive patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">2&#8211;5</span></a> Deaths from CKD increased by 82&#37; worldwide between 1990 and 2010&#59; this is the third uppermost increase out of the 25 leading causes of death after HIV&#47;AIDS &#40;396&#37;&#41; and diabetes &#40;93&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Hypertension &#40;HTN&#41; is the second most common cause of ESRD&#46; The number of cases of ESRD with a primary diagnosis of HTN is increasing&#44; especially in the individulas &#62;45 years&#44; this is a consequence of greater survival rates in kidney failure patients and longer life expectancy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In hypertensive patients with CKD&#44; blood pressure &#40;BP&#41; control is essential to minimise progression of CKD&#44; reduce complications inherent to kidney failure and reduce the associated risk of cardiovascular disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">1&#44;7&#44;8</span></a> However&#44; there is some debate about optimal values of BP&#46; In the latest guidelines&#44; the target BP of &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg has been limited to individuals with albuminuria of 30&#8211;300<span class="elsevierStyleHsp" style=""></span>mg&#47;dL<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> or overt albuminuria&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">7</span></a> while the target value of &#8804;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg has been maintained for the rest and&#44; in some cases<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">8</span></a> for all hypertensive patients&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Current recommendations for the diagnosis of CKD include standardised determination of creatinine and eGFR using the CKD-EPI formula&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> The CKD-EPI formula is more accurate at higher values of eGFR than previous formulas&#44; and many studies have shown that it provides a lower estimate of the prevalence of CKD and a better prognostic classification&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">9&#8211;11</span></a> In Spain there are no studies in hypertensive patients using the above criteria&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The objective of this study is to describe the prevalence and factors associated with a moderate decrease in eGFR &#40;30&#8211;59 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; estimated by CKD-EPI and to assess the degree of BP control in relation to wheter there is a reduction in eGFR&#44; following the most recent recommendations for hypertensive patients aged &#8805;60 years&#44; with no history of cardiovascular disease&#44; treated in Primary Care Facilitites&#46; This study is part of a cohort study primarily aiming to quantify the risk of cardiovascular events associated with a moderate decrease in eGFR and the progression of eGFR deterioration in relation to the degree of BP control in hypertensive individuals&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">This is a cross-sectional descriptive study&#46; The data were obtained from the Information System for the Development of Research in Primary Care &#40;SIDIAP&#41;&#44; which contains clinical information about patients treated at the 274 primary healthcare centres of the Catalan Institute of Health &#40;ICS&#41; in Catalonia&#44; which provides services to 5&#44;835&#44;000 patients &#40;80&#37; of the population&#41;&#46; To ensure the quality of the data&#44; a selected database&#44; <span class="elsevierStyleItalic">SIDIAP plus</span><a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">12</span></a> was used which has shown to be valid and representative of the population for cardiovascular epidemiology studies&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We selected individuals aged &#8805;60 years included in the <span class="elsevierStyleItalic">SIDIAP plus</span> database since January 1st 2011&#44; with a coded diagnosis of HTN &#40;CIE10 codes&#58; I10&#46; I15 and subcategories&#41; in the electronic primary care records&#44; with a minimum follow up of 2 years&#44; with measurement of standardised serum creatinine determination and BP at least once in the preceding 2 years&#44; and with a maximum interval of 6 months&#46; Exclusion criteria were&#58; a&#41; CKD stages 4 and 5 &#40;eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#44; dialysis or renal transplant&#41;&#59; b&#41; previous cardiovascular disease &#40;myocardial infarction&#44; angina&#44; established or transient cerebrovascular accident&#44; peripheral artery disease&#41;&#59; and c&#41; individuals included in a home care programme&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Renal function was assessed using CKD-EPI&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> without adjusting for race &#40;not available&#41;&#44; and KDIGO &#40;Kidney Disease Improving Global Outcomes&#41; classification&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> The last creatinine level and albumin&#47;creatinine ratio &#40;ACR&#41;&#44; determined prior to 01&#47;01&#47;2011&#44; were considered in each study subject&#46; Covariables were&#58; gender&#44; age&#44; rurality index &#40;according to municipality of residence&#58; urban if more than 10&#44;000 inhabitants and population density &#62;150<span class="elsevierStyleHsp" style=""></span>inhabitants&#47;km<span class="elsevierStyleSup">2</span>&#44; or rural if otherwise&#41;&#44; socioeconomic deprivation index &#40;MEDEA&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">14</span></a> smoking habit&#44; systolic &#40;SBP&#41; and diastolic &#40;DBP&#41; blood pressure&#44; weight and height&#44; glucose&#44; total cholesterol&#44; triglycerides&#44; HDL cholesterol&#44; LDL cholesterol&#44; and coded diagnoses of heart failure &#40;HF&#41; and atrial fibrillation&#46; As a criterion of contemporaneity&#44; we considered the median of all determinations with a maximum interval of 6 months between them&#44; as well as the median between the determinations and the relevant date of creatinine determination&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The presence of cardiovascular risk factors was defined as&#58; a&#41; <span class="elsevierStyleItalic">diabetes mellitus</span> &#40;DM&#41;&#58; codes E11&#44; E12&#44; E14 and subcategories &#40;2 determinations of fasting blood glucose &#62;126<span class="elsevierStyleHsp" style=""></span>mg&#47;dL or typical symptoms with random blood glucose &#62;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#59; b&#41; <span class="elsevierStyleItalic">hypercholesterolaemia</span>&#58; total cholesterol &#62;250<span class="elsevierStyleHsp" style=""></span>mg&#47;dL or lipid-lowering drugs&#59; c&#41; <span class="elsevierStyleItalic">smoking habit</span>&#58; smoker &#40;daily consumption of one or more cigarettes during the last month&#44; code F17&#41;&#44; ex-smoker &#40;more that 1 year with the diagnosis of smoker removed code Z72&#46;0&#41;&#59; and d&#41; <span class="elsevierStyleItalic">obesity</span>&#58; body mass index &#40;BMI&#41; &#8805;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">BP levels &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg were considered adequate BP control in individuals with albuminuria &#40;ACR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; BP levels &#8804;140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg were satisfactory for the remaining hypertensive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Information on pharmacological treatment was obtained from the pharmacy billing database&#44; based on the ATC code of each active ingredient&#46; The number of daily doses for each active ingredient taken from the pharmacy within &#177;6 months from the date of the baseline creatinine determination&#44; with respect to the time interval between the first and last withdrawn was recorded&#46; To estimate the level of exposure to each active ingredient&#44; therapeutic compliance was defined as purchase of more than 60&#37; of the total daily dose defined for the period&#46; Administration of antihypertensive drugs affecting renal function &#40;angiotensin-converting enzyme inhibitors&#44; angiotensin receptor blockers&#44; direct renin inhibitors&#44; aldosterone antagonists and other diuretics&#41; and other treatments that can modify cardiovascular risk &#40;antiplatelet agents&#44; lipid-lowering agents&#41; was monitored&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Continuous variables were described as median and interquartile range&#44; while qualitative variables were expressed as frequency and percentage&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test was used to compare quantitative variables and the chi-squared test for categorical variables between groups according to eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Multivariate logistic regression models adjusted for variables with <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;10 in the bivariate analysis was used to determine the variables associated with eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 and the correlation of these with gender&#44; age and DM&#46; Any effects that detracted from the quality of the model were progressively eliminated according to the <span class="elsevierStyleItalic">Akaike Information Criteria</span>&#46; The missing data were imputed according to the <span class="elsevierStyleItalic">Markov Chain Monte Carlo Multiple Imputation</span> method &#40;5 imputations&#44; 10 iterations&#59; correlations included in the process&#41;&#46; The resulting model was replicated without these data to observe the effect of data imputation&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Statistics were calculated using R&#44; version 2&#46;14&#46;2 &#40;R Foundation for Statistical Computing&#44; Vienna&#44; Austria&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The study was approved by the Independent Ethics Committee of the Jordi Gol Foundation for Primary Care Research &#40;IDIAP&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the selection process flow chart for the 263&#44;034 individuals aged &#8805;60 years with a diagnosis of HTN of 2 or more years of follow up included in the <span class="elsevierStyleItalic">SIDIAP plus</span> database as of 01&#47;01&#47;2011&#46; The final study population included 73&#44;730 individuals with a median age of 74 years&#44; of whom 62&#46;1&#37; were women &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Prevalence of chronic kidney disease and associated factors</span><p id="par0090" class="elsevierStylePara elsevierViewall">In total&#44; 18&#46;8&#37; of the study subjects presented with moderate CKD&#59; in 72&#46;2&#37; of these&#44; eGFR was between 45 and 59<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#46; Prevalence was higher in women &#40;19&#46;9&#37; in women versus 17&#46;0&#37; in men&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; and increased with age&#44; from 5&#46;88&#37; at 60&#8211;69 years to 39&#46;4&#37; in subjects &#62;80 years&#46; Individuals with decreased eGFR were older&#44; with a higher percentage of women&#44; from rural areas&#44; diabetes mellitus&#44; dyslipidaemia&#44; HF and atrial fibrillation&#44; a lower percentage of smokers&#47;ex-smokers and obesity&#44; and a lower socioeconomic level &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; which increased significantly with the low eGFR level &#40;global <span class="elsevierStyleItalic">p</span> and linear trend &#60;0&#46;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Urinary ACR was available in 51&#46;6&#37; of the individuals &#40;50&#46;9&#37; in the eGFR<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 group and 54&#46;4&#37; in the eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 group&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; it was pathological in 13&#46;1&#37;&#46; Supplementary Table 1 shows the descriptive data with imputations&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">A multivariate analysis to assess the variables associated with eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 showed that gender&#44; age&#44; HF&#44; ACR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; atrial fibrillation&#44; smoking&#44; dyslipidaemia&#44; DM and obesity were significant factors &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Significant interactions were detected&#59; the older the age of the patient&#44; the weaker the correlation between male gender and eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; This correlation was inverted from the age of 80&#44; when the risk of CKD was greater in women than in men&#46; Correlation with age was similar for ACR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and diagnosis of HF and DM&#46; In men&#44; the correlation between decreased eGFR and pathological ACR increased&#44; whereas the correlation between decreased eGFR and DM&#44; obesity and smoking habit decreased&#46; In the case of DM&#44; the risk was greater in the presence of obesity and lower in smokers and ex-smokers&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">To observe the effect of imputations&#44; the final multivariate model was replicated without them &#40;Supplementary Table 2&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Blood pressure and exposure to drugs</span><p id="par0110" class="elsevierStylePara elsevierViewall">The median SBP and DBP were 136 and 76<span class="elsevierStyleHsp" style=""></span>mmHg&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; SBP did not differ significantly among individuals with and without decreased eGFR&#44; but DBP was lower in the group with kidney disease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The level of BP control was 65&#46;6&#37; &#40;66&#46;5&#37; in SBP and 94&#46;6&#37; in DBP&#41;&#46; In individuals with decreased eGFR&#44; BP control was lower overall and for SBP&#44; and higher for DBP &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Exposure to antiplatelet&#44; lipid-lowering and antihypertensive drugs was higher in hypertensive patients with CKD&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0125" class="elsevierStylePara elsevierViewall">The prevalence of moderate CKD &#40;eGFR 30&#8211;59<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; in &#8805;60 years individuals&#44; with HTN of more than 2 years and without cardiovascular disease&#44; was 18&#46;8&#37;&#46; It was associated with older age&#44; male gender&#44; HF&#44; pathological ACR&#44; atrial fibrillation&#44; smoking&#44; dyslipidaemia&#44; DM and obesity&#46; Percent of BP control &#40;overall 65&#46;6&#37;&#41; was slightly less in individuals with decreased eGFR&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The prevalence of moderate CKD is comparable to that previously reported in hypertensive patients &#40;17&#46;2&#37; in &#8805;55 years<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">15</span></a> and 21&#46;8&#37; in primary care in Italy<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">16</span></a>&#41; and lower than that reported in Spain &#40;from 24&#46;4&#37; to 27&#46;4&#37;&#44;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">17&#8211;19</span></a> and as high as 50&#37; in hypertensive women aged &#8805;65 years<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">20</span></a>&#41;&#46; These differences may be due to the use of non-standardised creatinine determinations and to the calculating eGFR using the MDRD study equation&#44; which underestimates eGFR at higher values&#44; especially in young individuals and women&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> as well as to the inclusion of individuals with previous cardiovascular disease associated with CKD&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">This study shows a strong positive correlation between older age and increased risk of decreased eGFR&#46; This association has been widely described both in the general population<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">21</span></a> and in hypertensive individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;19&#44;22&#44;23</span></a> In our study&#44; age also affected other risk factors&#58; the older the individual&#44; the lesser the impact of male gender&#44; pathological ACR&#44; DM&#44; atrial fibrillation and HF on CKD&#46; This suggests that age predominates over the other risk factors in older individuals&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The correlation observed between gender and CKD is similar to that described in the literature&#46; The prevalence of CKD is generally higher in women&#44;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">15&#8211;18&#44;22</span></a> but when adjusted for other risk factors&#44; male gender is associated with the presence of CKD<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">11&#44;24</span></a> and a greater risk of progression to ESRD&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">25</span></a> The possibility that the eGFR equation is not correctly adjusted for age and gender cannot be ruled out&#46; The CKD-EPI formula improves these aspects overall&#44; compared with the MDRD study equation&#44; but in the Three-city Prospective Cohort Study<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> in older individuals&#44; CKD-EPI did not show superiority in identifying individuals with poor prognosis&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In our analysis&#44; pathological ACR was a risk factor for CKD&#44; with more impact in men&#46; Albuminuria is a known risk factor for CKD<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">23&#44;27</span></a> and progression to ESRD in hypertensive patients&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> In this respect&#44; it is important to emphasise that ACR determination was available in only half of all study cases&#44; and showed a minimum increase in eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#44; despite the recommendations of clinical guidelines for the management of HTN<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">7</span></a> and CKD&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In this study&#44; decreased eGFR was also significantly correlated with HF and&#44; to a lesser degree&#44; with atrial fibrillation&#46; The correlation with HF&#44;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">24</span></a> left ventricular hypertrophy<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">15&#44;16&#44;18</span></a> and cardiovascular disease<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">15&#44;16&#44;18&#44;20&#44;22&#44;28</span></a> has been described in other studies&#46; HF is also a risk factor for CKD progression&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">29</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The presence of other cardiovascular risk factors in hypertensive patients is known to increase the risk of CKD&#44;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">19&#44;20&#44;27</span></a> and it is therefore considered a further manifestation of the atherosclerotic process&#46; Smoking has been described as a predictor of albuminuria&#44; especially in men&#44; but not of eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">23&#44;30</span></a> In our analysis&#44; the increased risk of CKD associated with DM&#44; obesity and smoking was lower in males&#46; Interestingly&#44; in the case of DM&#44; the risk was greater in the presence of obesity and lower in smokers&#46; All these effects may be assessed in greater detail in the follow-up of this cohort of hypertensive individuals aged &#8805;60 years&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">There is some debate about ideal BP levels&#44; which have varied in recent years and making comparisons difficult&#46; The 65&#46;6&#37; BP control obtained in our population is comparable to the 61&#46;1&#37; with &#60;140&#47;90 described in hypertensive patients seen in Primary Care&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">31</span></a> while in individuals with CKD&#44; 63&#46;24&#37; is comparable to the 60&#46;2&#37; described with the same criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">32</span></a> These percentages are much higher than those published in previous studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">22&#44;23</span></a> and are in line with the improvement observed in the control of HTN in recent years<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">31</span></a> or in severe cases of HTN&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">20</span></a> However&#44; this improvement should be interpreted with caution&#44; since individuals with no BP data over the study period were not included in our analysis&#46; It should be emphasised that individuals with CKD have worse BP control&#44; despite greater exposure to drugs&#46; This situation&#44; which has also been described in other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">16&#44;22&#44;24</span></a> shows the difficulty involved in controlling BP in these individuals&#46; Nevertheless&#44; some degree of therapeutic inertia or failure to prioritise BP control in these at-risk individuals cannot be ruled out&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The strength of this study is the large size of the population-based sample&#44; which was taken from a validated and representative database used in cardiovascular epidemiology studies&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a> Creatinine determination&#44; which was carried out in several laboratories&#44; was performed according to standardised methods aligned with IDMS&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Limitations of the study are its cross-sectional design&#44; which prevents us from inferring causal associations&#46; The results are representative of the hypertensive population without cardiovascular disease&#44; treated and monitored in Primary Care&#46; This population could possibly have a lower prevalence of decreased eGFR and better control of BP&#46; The main objective of the project&#44; of which this study is part&#44; is to quantify the risk of cardiovascular events associated with a moderate decrease in eGFR&#46; For this reason&#44; individuals with previous cardiovascular disease were excluded&#44; due to a higher incidence of new episodes and difficulties in distinguishing between new episodes and follow-up of previous ones using the data available in electronic medical records&#46; BP records reflect standard clinical practice&#46; As the specific circumstances of BP measurements are not recorded &#40;single determination or the average of a series&#44; rest conditions&#44; etc&#46;&#41;&#44; the existence of heterogeneity among centres or professionals cannot be ruled out&#46; The degree of BP control was not included in the multivariate analysis&#44; because&#44; in a cross-sectional study&#44; it does not reflect the previous effect of BP on the presence of CKD&#46; The analysis was performed using a single creatinine determination&#44; which is common in epidemiological studies and also for ACR&#46; Furthermore&#44; data were not adjusted for race&#44; because given the population characteristics in our setting&#44; i&#46;e&#46;&#44; a clear predominance of Caucasians particularly in this age group&#44; we believe this variable to be of little relevance&#46; Finally&#44; data for some variables were unavailable in many cases&#58; regarding ACR&#44; for example&#44; as much as 48&#46;8&#37; of the data was missing&#46; In these cases&#44; the analysis of data without imputation could cause significant bias&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Despite its obvious advantages&#44; multiple imputation of missing data using the Markov Chain Monte Carlo methods is not without its limitations&#46; First&#44; such method assumes that the missing data are random&#44; that is&#44; that they can be explained without bias by the remaining variables collected&#46; Second&#44; the imputation method incorporates a variability associated with the unavailability of the observed data&#44; so it is less likely to detect associations with imputed data than if all data were observed&#46; However&#44; the final multivariate model replicated without imputations yielded very similar results&#44; the main differences being a greater association between decreased eGFR and the rest of the risk factors when excluding ACR and the non-attenuation of the DM risk in men&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; 1 out of 5 hypertensive individuals without cardiovascular disease&#44; aged 60 or over and treated and monitored by Primary Care has a moderatedecreased eGFR&#44; with albuminuria and HF as the main associated factors&#46; Despite increased drug exposure&#44; the control of BP control was poor in individuals with decreased eGFR&#46; The follow-up of this cohort with and without moderately decreased eGFR will allow us to identify the factors associated with greater progression of kidney failure and incidence of cardiovascular events in our setting&#46; Given the relevance of albuminuria in both the progression of CKD and cardiovascular risk&#44; we believe that strategies to increase this determination in Primary Care should be explored&#44; particularly in patients with kidney disease&#44; and BP control should be prioritised and optimised in these individuals&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Comments</span><p id="par0185" class="elsevierStylePara elsevierViewall">This study was carried out with anonymised data from Primary Care electronic medical records provided by SIDIAP &#40;Information System for the Development of Research in Primary Care&#41;&#46; To use these data&#44; the project was evaluated by the Scientific Committee of SIDIAP and approved by the Independent Ethics Committee of the Jordi Gol Foundation for Primary Care Research &#40;IDIAP&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">This study was supported by a grant from <span class="elsevierStyleGrantSponsor" id="gs1">SIDIAP</span> &#40;Information System for the Development of Research in Primary Care&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hypertension &#40;HT&#41; is the second leading cause of kidney failure&#46; In hypertensive patients with chronic kidney disease &#40;CKD&#41;&#44; blood pressure &#40;BP&#41; control is the most important intervention to minimise progression&#46; For CKD diagnosis&#44; standardised creatinine and estimated glomerular filtration rate &#40;eGFR&#41; testing by CKD-EPI is recommended&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To describe the prevalence and factors associated with a moderate decrease in eGFR &#40;by CKD-EPI&#41; and BP control in subjects with HT&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional descriptive study in subjects &#8805;60 years included in the <span class="elsevierStyleItalic">SIDIAP plus</span> database with hypertension and standardised serum creatinine and BP tests in the last 2 years&#46; Exclusion criteria&#58; eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; dialysis or kidney transplantation&#44; prior cardiovascular disease&#44; home care&#46; Primary endpoint&#58; eGFR by CKD-EPI formula&#46; Covariates&#58; demographic data&#44; examination&#44; cardiovascular risk factors&#44; heart failure and auricular fibrillation diagnosis&#44; and drugs &#40;antihypertensive agents acting on renal function&#44; antiplatelet and lipid lowering agents&#41;&#46; BP control criteria&#58; &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg in individuals with albuminuria&#44; &#8804;140&#47;90 in all other subjects&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Prevalence of eGFR &#60;60<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#46;8&#37;&#46; Associated factors&#58; age&#44; gender&#44; heart failure&#44; albumin&#47;creatinine ratio&#44; auricular fibrillation&#44; smoking&#44; dyslipidaemia&#44; diabetes and obesity&#46; BP control&#58; 66&#46;14 and 63&#46;24&#37; in eGFR<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 and eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#44; respectively &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Exposure to drugs was higher in eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">One in 5 hypertensive patients without cardiovascular disease &#8805;60 years in primary care presented with a moderate decrease in eGFR&#46; In addition to age and sex&#44; albuminuria and heart failure were the main associated factors&#46; Despite the increased exposure to drugs&#44; BP control was lower in CKD&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La hipertensi&#243;n arterial &#40;HTA&#41; es la segunda causa de insuficiencia renal&#46; En hipertensos con enfermedad renal cr&#243;nica &#40;ERC&#41; el control de la presi&#243;n arterial &#40;PA&#41; es la intervenci&#243;n m&#225;s importante para minimizar la progresi&#243;n&#46; Para el diagn&#243;stico de ERC se recomienda la determinaci&#243;n estandarizada de creatinina y filtrado glomerular estimado &#40;FGe&#41; seg&#250;n CKD-EPI&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Describir la prevalencia y los factores asociados a la disminuci&#243;n moderada del FGe &#40;seg&#250;n CKD-EPI&#41; y el control de PA en individuos con HTA&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo transversal en individuos &#8805;60 a&#241;os incluidos en la base de datos SIDIAP plus con HTA y registro de creatinina s&#233;rica estandarizada y PA en &#250;ltimos 2<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; Criterios de exclusi&#243;n&#58; FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&#44; di&#225;lisis o trasplante renal&#44; enfermedad cardiovascular previa&#44; atenci&#243;n domiciliaria&#46; Variable principal&#58; FGe seg&#250;n CKD-EPI&#46; Covariables&#58; datos demogr&#225;ficos&#44; exploraci&#243;n&#44; factores de riesgo cardiovascular&#44; diagn&#243;sticos de insuficiencia cardiaca y fibrilaci&#243;n auricular y f&#225;rmacos &#40;antihipertensivos con acci&#243;n sobre funci&#243;n renal&#44; antiagregantes&#44; hipolipidemiantes&#41;&#46; Criterio de control de la PA&#58; &#8804;130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg en individuos con albuminuria&#44; &#8804;140&#47;90 en el resto&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Prevalencia FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#58; 18&#44;8&#37;&#46; Factores asociados&#58; edad&#44; sexo&#44; insuficiencia cardiaca&#44; cociente alb&#250;mina&#47;creatinina&#44; fibrilaci&#243;n auricular&#44; h&#225;bito tab&#225;quico&#44; dislipidemia&#44; diabetes y obesidad&#46; Control de la PA&#58; 66&#44;14 y 63&#44;24&#37; en FGe<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 y FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 respectivamente &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La exposici&#243;n a f&#225;rmacos fue superior en FGe<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Uno de cada 5<span class="elsevierStyleHsp" style=""></span>hipertensos sin enfermedad cardiovascular &#8805;60 a&#241;os en atenci&#243;n primaria present&#243; disminuci&#243;n moderada del FGe&#46; Adem&#225;s de la edad y el sexo&#44; la albuminuria y la insuficiencia cardiaca fueron los principales factores asociados&#46; A pesar de la mayor exposici&#243;n a f&#225;rmacos&#44; el control de la PA fue inferior en ERC&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Salvador-Gonz&#225;lez B&#44; Mestre-Ferrer J&#44; Soler-Vila M&#44; Pascual-Benito L&#44; Alonso-Bes E&#44; Cunillera-Pu&#233;rtolas O&#44; et al&#46; Enfermedad renal cr&#243;nica en individuos hipertensos &#8805;60 a&#241;os atendidos en Atenci&#243;n Primaria&#46; Nefrologia&#46; 2017&#59;37&#58;406&#8211;414&#46;</p>"
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        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">MACAP Renal&#46; Research group recognised by the Generalitat of Catalonia &#40;i&#46;e&#46;&#44; the local government of Catalonia&#41; &#40;SGR 2014-2016&#41;&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">MACAP Costa de Ponent&#46; Jordi Gol Foundation for Primary Care Research &#40;IDIAP&#41;&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">For members in MARREC-HTA project research group see <a class="elsevierStyleCrossRef" href="#sec0055">Appendix A</a>&#46;</p>"
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            "apendice" => "<p id="par0200" class="elsevierStylePara elsevierViewall">M&#46; Jes&#250;s Cerain Herrero&#44; Esther Freixes Villar&#243;&#44; Neus Gil Terr&#243;n&#44; Mercedes Rodr&#237;guez Pascual&#44; Laura Ruip&#233;rez Guijarro&#44; Llu&#239;sa Rodr&#237;guez Latre&#44; Isabel Rosich Mart&#237;&#44; Gemma Rodr&#237;guez Palomar&#44; Jes&#250;s Almeda Ortega&#44; Francisco Javier Tovillas Mor&#225;n and Alberto Mart&#237;nez Castelao&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "MARREC-HTA project research group"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estimation&#44; based on the logistic regression model&#44; of the probability of subjects included in the sample of hypertensive individuals aged &#8805;60 years&#44; taken from the <span class="elsevierStyleItalic">SIDIAP plus</span> database as of 1st January 2011&#44; being in the glomerular filtration rate &#60;60 group&#44; according to age and gender &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&#41;&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estimates for non-smokers with albumin&#47;creatinine ratio &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; without dyslipidaemia&#44; obesity&#44; atrial fibrillation&#44; heart failure or diabetes&#44; living in an urban environment and in the central quintile of the MEDEA socioeconomic level&#46; For any other individual profile&#44; the expected probabilities according to the logistic regression model differ from those shown&#46; However&#44; the effect of the age-gender correlation shown is maintained&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">ACR&#58; urinary albumin&#47;creatinine ratio&#59; BMI&#58; body mass index&#59; DBP&#58; diastolic blood pressure&#59; SBP&#58; systolic blood pressure&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Numerical variables are shown with the overall median &#91;1st quartile&#59; 3rdquartile&#93; according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#44; the <span class="elsevierStyleItalic">p</span>-value of the Kruskal&#8211;Wallis test of equal distribution of the variable according to the eGFRCKD-EPI group&#44; and the p-value of the Spearman&#39;s rank correlation coefficient&#46; Categorical variables are shown with the overall absolute frequency &#40;relative frequency&#41; according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#44; the p-value of the chi-squared test of equal distribution of the variable according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#44; and the <span class="elsevierStyleItalic">p</span>-value of the chi-squared linear trend test&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Overall <span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR &#8805; 60<br><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>59&#44;863 &#40;81&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR 45&#8211;60<br><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#44;017 &#40;13&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR 30&#8211;44<br><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3850 &#40;5&#46;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Overall <span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Trend <span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Age</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#46;0 &#40;67&#46;0&#59; 80&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#46;0 &#40;66&#46;0&#59; 78&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#46;0 &#40;74&#46;0&#59; 84&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#46;0 &#40;77&#46;0&#59; 86&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Gender &#40;female&#41; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#44;778 &#40;62&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;670 &#40;61&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6443 &#40;64&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2665 &#40;69&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Rurality n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7826 &#40;10&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6284 &#40;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1042 &#40;10&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">500 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;706&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">MEDEA index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;75 &#40;0&#46;15&#59; 1&#46;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;75 &#40;0&#46;16&#59; 1&#46;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;75 &#40;0&#46;13&#59; 1&#46;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;67 &#40;0&#46;07&#59; 1&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Smoking history n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#44;742&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Non-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#44;375 &#40;75&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#44;630 &#40;74&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7713 &#40;79&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3032 &#40;81&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4943 &#40;6&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4343 &#40;7&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">436 &#40;4&#46;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">164 &#40;4&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ex-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;424 &#40;17&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;294 &#40;17&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1615 &#40;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">515 &#40;13&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">BMI &#40;kg&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;4 &#40;26&#46;7&#59; 32&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;5 &#40;26&#46;8&#59; 32&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;3 &#40;26&#46;6&#59; 32&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;0 &#40;26&#46;2&#59; 32&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#44;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Blood glucose &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#40;91&#46;0&#59; 120&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101 &#40;91&#46;0&#59; 120&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100 &#40;90&#46;5&#59; 118&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100 &#40;90&#46;0&#59; 119&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;232&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Total cholesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">205 &#40;181&#59; 229&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">206 &#40;182&#59; 230&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">201 &#40;177&#59; 226&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">199 &#40;174&#59; 224&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&#44;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Triglycerides &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">114 &#40;86&#46;5&#59; 153&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">112 &#40;85&#46;0&#59; 151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">120 &#40;91&#46;0&#59; 160&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#40;95&#46;0&#59; 166&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#44;455&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HDL cholesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#46;0 &#40;45&#46;0&#59; 63&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#46;0 &#40;45&#46;0&#59; 63&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;0 &#40;44&#46;0&#59; 62&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;0 &#40;43&#46;0&#59; 61&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#44;649&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">LDL cholesterol &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#40;104&#59; 146&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125 &#40;104&#59; 147&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">120 &#40;100&#59; 143&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118 &#40;97&#46;0&#59; 140&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#44;332&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Creatinine &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;83 &#40;0&#46;70&#59; 1&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;79 &#40;0&#46;69&#59; 0&#46;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;07 &#40;0&#46;98&#59; 1&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;36 &#40;1&#46;21&#59; 1&#46;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">eGFR &#40;mL&#47;min&#47;1&#46;73</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#46;3 &#40;64&#46;3&#59; 88&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&#46;5 &#40;72&#46;6&#59; 89&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#46;9 &#40;50&#46;0&#59; 57&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#46;6 &#40;35&#46;7&#59; 42&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ACR &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;40 &#40;3&#46;70&#59; 14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;00 &#40;3&#46;60&#59; 12&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;80 &#40;4&#46;00&#59; 21&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;0 &#40;5&#46;30&#59; 39&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ACR &#62; 30</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mg&#47;dL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4970 &#40;13&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3272 &#40;10&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1053 &#40;19&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">645 &#40;29&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#44;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes mellitus n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44;633 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;306 &#40;28&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3028 &#40;30&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1299 &#40;33&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Obesity n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44;616 &#40;45&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44;089 &#40;45&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3336 &#40;43&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1191 &#40;41&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#44;658&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Hypercholesterolaemia n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;704 &#40;51&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#44;353 &#40;50&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5257 &#40;52&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2094 &#40;54&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Heart failure n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3111 &#40;4&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1844 &#40;3&#46;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">779 &#40;7&#46;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">488 &#40;12&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Atrial fibrillation n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5127 &#40;6&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3489 &#40;5&#46;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1120 &#40;11&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">518 &#40;13&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#44;730&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the sample of hypertensive individuals aged &#8805;60 years&#44; in the total sample selected&#44; according to eGFR<span class="elsevierStyleInf">CKD-EPI</span> &#8805;60&#44; 45&#8211;59 or &#60;30&#8211;44 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&#41;&#44; taken from the <span class="elsevierStyleItalic">SIDIAP plus</span> database as of 1 January 2011&#46;</p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Model based on gender&#44; age of 60 years&#44; ACR&#44; DM&#44; dyslipidaemia&#44; obesity&#44; smoking habit&#44; HF&#44; AF&#44; rurality&#40;from rural areas&#41;&#44; MEDEA and the correlation between these variables and gender&#44; age and DM &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&#41;&#59; final model presented as a result of the selection of variables using the Akaike Information Criteria&#59; imputation of missing data&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">95&#37; CI&#58; 95&#37; confidence interval of OR&#59; ACR&#58; urinary albumin&#8211;creatinine ratio&#59; AF&#58; atrial fibrillation&#59; DM&#58; diabetes mellitus&#59; HF&#58; heart failure&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio</span> calculated as the exponential of the coefficients of the model&#59; <span class="elsevierStyleItalic">p</span>&#58; <span class="elsevierStyleItalic">p</span>-value of the coefficient of the logistic regression model&#46;</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">The correlations presented in the table start with a &#8220;-&#8221; sign and a &#8220;&#58;&#8221; between the 2 correlated effects&#46;</p><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Model adjusted for rurality and age&#58;obesity&#44; age&#58;AF&#44; age&#58;rurality and DM&#58;AF correlations&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Model with ACR</th><th class="td" title="table-head  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Coef&#46; &#40;Std Err&#46;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">&#40;Intercept&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;3&#46;691 &#40;0&#46;183&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gender &#40;male&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;421 &#40;0&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;524 &#40;1&#46;186&#59; 1&#46;956&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;123 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;130 &#40;1&#46;111&#59; 1&#46;151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ACR &#62;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;022 &#40;0&#46;117&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;780 &#40;2&#46;205&#59; 3&#46;492&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;030 &#40;0&#46;105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;031 &#40;0&#46;839&#59; 1&#46;264&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;773&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Dyslipidaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;217 &#40;0&#46;033&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;242 &#40;1&#46;165&#59; 1&#46;325&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;080 &#40;0&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;083 &#40;0&#46;896&#59; 1&#46;310&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;409&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;354 &#40;0&#46;168&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;425 &#40;1&#46;017&#59; 1&#46;964&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;035&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ex-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;278 &#40;0&#46;107&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;320 &#40;1&#46;067&#59; 1&#46;626&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">AF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;072 &#40;0&#46;195&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;074 &#40;0&#46;729&#59; 1&#46;568&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;714&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;362 &#40;0&#46;191&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;906 &#40;2&#46;672&#59; 5&#46;656&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Rurality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;145 &#40;0&#46;167&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;865 &#40;0&#46;628&#59; 1&#46;207&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MEDEA quintile 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;076 &#40;0&#46;065&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;079 &#40;0&#46;949&#59; 1&#46;226&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MEDEA quintile 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;027 &#40;0&#46;065&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;973 &#40;0&#46;857&#59; 1&#46;105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;677&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MEDEA quintile 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;089 &#40;0&#46;063&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;093 &#40;0&#46;966&#59; 1&#46;237&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;158&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">MEDEA quintile 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;089 &#40;0&#46;062&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;093 &#40;0&#46;968&#59; 1&#46;234&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;018 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;983 &#40;0&#46;973&#59; 0&#46;992&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; ACR<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;403 &#40;0&#46;084&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;496 &#40;1&#46;269&#59; 1&#46;765&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;091 &#40;0&#46;080&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;913 &#40;0&#46;781&#59; 1&#46;068&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;225 &#40;0&#46;069&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;799 &#40;0&#46;697&#59; 0&#46;915&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;431 &#40;0&#46;183&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;650 &#40;0&#46;456&#59; 0&#46;937&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; ex-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;270 &#40;0&#46;112&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;764 &#40;0&#46;614&#59; 0&#46;953&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;087 &#40;0&#46;115&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;917 &#40;0&#46;732&#59; 1&#46;147&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;448&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; MEDEA q 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;080 &#40;0&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;923 &#40;0&#46;751&#59; 1&#46;136&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;450&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; MEDEA q 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;003 &#40;0&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;997 &#40;0&#46;810&#59; 1&#46;227&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; MEDEA q 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;158 &#40;0&#46;105&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;854 &#40;0&#46;695&#59; 1&#46;049&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Gender &#40;M&#41;&#58; MEDEA q 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;056 &#40;0&#46;104&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;946 &#40;0&#46;772&#59; 1&#46;159&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;592&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; pathological ACR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;028 &#40;0&#46;006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;972 &#40;0&#46;962&#59; 0&#46;983&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; DM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;007 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;993 &#40;0&#46;984&#59; 1&#46;002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; dyslipidaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;002 &#40;0&#46;005&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;002 &#40;0&#46;993&#59; 1&#46;011&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;716&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;006 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;006 &#40;0&#46;989&#59; 1&#46;023&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;040 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;961 &#40;0&#46;944&#59; 0&#46;979&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-Age&#58; rurality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;011 &#40;0&#46;009&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;011 &#40;0&#46;994&#59; 1&#46;028&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;219&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-DM&#58; obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;111 &#40;0&#46;066&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;117 &#40;0&#46;983&#59; 1&#46;270&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;091&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-DM&#58; smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;432 &#40;0&#46;159&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;649 &#40;0&#46;475&#59; 0&#46;885&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-DM&#58; ex-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;101 &#40;0&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;904 &#40;0&#46;748&#59; 1&#46;092&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;293&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">-DM&#58; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;034 &#40;0&#46;109&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;035 &#40;0&#46;836&#59; 1&#46;281&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;754&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Multivariate logistic regression model for eGFRCKD-EPI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">ACE inhibitors&#58; angiotensin-converting enzyme inhibitors&#59; ARBs&#58; angiotensin receptor blockers&#59; BP&#58; blood pressure&#59; DBP&#58; diastolic blood pressure&#59; DRIs&#58; dopamine reuptake inhibitors&#59; SBP&#58; systolic blood pressure&#46;</p><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Numerical variables are shown with the overall median &#91;1st quartile&#59; 3rdquartile&#93; and according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#44; and the <span class="elsevierStyleItalic">p</span>-value of the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span>-test of equal distribution of the variable according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#46; Categorical variables are shown with the overall absolute frequency &#40;relative frequency&#41;&#44; according to the eGFR<span class="elsevierStyleInf">CKD-EPI</span> group&#44; and the <span class="elsevierStyleItalic">p</span>-value of the chi-squared test of equal distribution of the variable according to the eGFRCKD-EPI group&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Overall <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">eGFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60 <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">59&#44;863 &#40;81&#46;2&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">13&#44;867 &#40;18&#46;8&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SBP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#46;00 &#40;129&#46;00&#59; 143&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#46;00 &#40;129&#46;50&#59; 143&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">136&#46;00 &#40;128&#46;00&#59; 144&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;165&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">DBP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;00 &#40;70&#46;00&#59; 81&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;00 &#40;70&#46;50&#59; 82&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;50 &#40;68&#46;00&#59; 80&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ACE inhibitors&#47;ARBs&#47;DRIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#44;187 &#40;68&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44;718 &#40;66&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;469 &#40;75&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">BP control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#44;365 &#40;65&#46;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44;596 &#40;66&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8769 &#40;63&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SBP control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#44;992 &#40;66&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#44;118 &#40;67&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8874 &#40;63&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">DBP control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#44;758 &#40;94&#46;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#44;549 &#40;94&#46;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;209 &#40;95&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Antiplatelets&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;099 &#40;17&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9807 &#40;16&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3292 &#40;23&#46;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lipid-lowering drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;464 &#40;23&#46;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;874 &#40;23&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3590 &#40;25&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;631 &#40;57&#46;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;352 &#40;55&#46;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9279 &#40;66&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Aldosterone antagonists&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">238 &#40;0&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">150 &#40;0&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88 &#40;0&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ACE inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#44;523 &#40;44&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;074 &#40;43&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6449 &#40;46&#46;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ARA II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;872 &#40;26&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;312 &#40;25&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4560 &#40;32&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">DRIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">272 &#40;0&#46;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">192 &#40;0&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;0&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ACE inhibitors&#47;ARBs&#47;DRIs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#44;187 &#40;68&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#44;718 &#40;66&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;469 &#40;75&#46;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">SBP<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>140 and DBP<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>90 &#40;SBP<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>130 and DBP<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>80 if albumin&#47;creatinine ratio &#62;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Blood pressure and exposure to drugs in the sample of hypertensive individuals aged &#8805;60 years&#44; in the total sample selected&#44; and according to eGFR<span class="elsevierStyleInf">CKD-EPI</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60 or &#8805;60 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>73&#44;730&#41;&#44; taken from the <span class="elsevierStyleItalic">SIDIAP plus</span> database as of 1st January 2011&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Kidney Disease&#58; Improving Global Outcomes &#40;KDIGO&#41; CKD Work GroupKDIGO clinical practice guideline for the evaluation and management of chronic kidney disease"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Kidney Int Suppl"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "1"
                        "paginaFinal" => "150"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic kidney disease and the risks of death&#44; cardiovascular events&#44; and hospitalization"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;S&#46; Go"
                            1 => "G&#46;M&#46; Chertow"
                            2 => "D&#46; Fan"
                            3 => "CE HC McCulloch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa041031"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15385656"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0175"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts&#58; a collaborative meta-analysis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Matsushita"
                            1 => "M&#46; van der Velde"
                            2 => "B&#46; Astor"
                            3 => "M&#46; Woodward"
                            4 => "A&#46; Levey"
                            5 => "P&#46; de Jong"
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                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(10)60674-5"
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                        "tituloSerie" => "Lancet"
                        "fecha" => "2010"
                        "volumen" => "375"
                        "paginaInicial" => "2073"
                        "paginaFinal" => "2081"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20483451"
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                          ]
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              ]
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              "identificador" => "bib0180"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes&#46; A collaborative meta-analysis of general and high-risk population cohorts"
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                        0 => array:2 [
                          "etal" => true
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                            0 => "R&#46;T&#46; Gansevoort"
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                            2 => "M&#46; van der Velde"
                            3 => "B&#46;C&#46; Astor"
                            4 => "M&#46; Woodward"
                            5 => "A&#46;S&#46; Levey"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1038/ki.2010.531"
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                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2011"
                        "volumen" => "80"
                        "paginaInicial" => "93"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21289597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0185"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension&#58; a meta-analysis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;K&#46; Mahmoodi"
                            1 => "K&#46; Matsushita"
                            2 => "M&#46; Woodward"
                            3 => "P&#46;J&#46; Blankestijn"
                            4 => "M&#46; Cirillo"
                            5 => "T&#46; Ohkubo"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Lancet"
                        "fecha" => "2012"
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                        "paginaInicial" => "1649"
                        "paginaFinal" => "1661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23013600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0190"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010&#58; a systematic analysis for the Global Burden of Disease Study 2010"
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                        0 => array:2 [
                          "etal" => true
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                            0 => "R&#46; Lozano"
                            1 => "M&#46; Naghavi"
                            2 => "K&#46; Foreman"
                            3 => "S&#46; Lim"
                            4 => "K&#46; Shibuya"
                            5 => "V&#46; Aboyans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(12)61728-0"
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                        "tituloSerie" => "Lancet"
                        "fecha" => "2012"
                        "volumen" => "380"
                        "paginaInicial" => "2095"
                        "paginaFinal" => "20128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23245604"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0195"
              "etiqueta" => "7"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "ESH&#47;ESC guidelines for the management of arterial hypertension&#58; the Task Force for the management of arterial hypertension of the European Society of Hypertension &#40;ESH&#41; and of the European Society of Cardiology &#40;ESC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Mancia"
                            1 => "R&#46; Fagard"
                            2 => "K&#46; Narkiewicz"
                            3 => "J&#46; Redon"
                            4 => "A&#46; Zanchetti"
                            5 => "M&#46; B&#246;hm"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/eht151"
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                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2013"
                        "volumen" => "34"
                        "paginaInicial" => "2159"
                        "paginaFinal" => "2219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23771844"
                            "web" => "Medline"
                          ]
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                      ]
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                  ]
                ]
              ]
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              "identificador" => "bib0200"
              "etiqueta" => "8"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2014 USRDS annual data report&#58; epidemiology of kidney disease in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "United States Renal Data System"
                          ]
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                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2014"
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                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0205"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new equation to estimate glomerular filtration rate"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Levey"
                            1 => "L&#46;A&#46; Stevens"
                            2 => "C&#46;H&#46; Schmid"
                            3 => "Y&#46;L&#46; Zhang"
                            4 => "A&#46;F&#46; Castro"
                            5 => "H&#46;I&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-150-9-200905050-60000"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2009"
                        "volumen" => "150"
                        "paginaInicial" => "604"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19414839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0210"
              "etiqueta" => "10"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical risk implications of the CKD epidemiology collaboration &#40;CKD-EPI&#41; equation compared with the Modification of Diet in Renal Disease &#40;MDRD&#41; study equation for estimated GFR"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46; Matsushita"
                            1 => "M&#46; Tonelli"
                            2 => "A&#46; Lloyd"
                            3 => "A&#46;S&#46; Levey"
                            4 => "J&#46; Coresh"
                            5 => "B&#46;R&#46; Hemmelgarn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.03.0162012"
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                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2012"
                        "volumen" => "60"
                        "paginaInicial" => "241"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22560843"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0215"
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                    0 => array:2 [
                      "titulo" => "Enfermedad renal cr&#243;nica en Atenci&#243;n Primaria&#58; prevalencia y factores de riesgo asociados"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Salvador Gonz&#225;lez"
                            1 => "M&#46; Rodr&#237;guez Pascual"
                            2 => "L&#46; Ruip&#233;rez Guijarro"
                            3 => "A&#46; Ferr&#233; Gonz&#225;lez"
                            4 => "O&#46; Cunillera Puertolas"
                            5 => "L&#46;M&#46; Rodr&#237;guez Latre"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.aprim.06.0032014"
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                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "2015"
                        "volumen" => "47"
                        "paginaInicial" => "236"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25212720"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Construction and validation of a scoring system for the selection of high-quality data in a Spanish population primary care database &#40;SIDIAP&#41;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "E&#46; Hermosilla"
                            2 => "D&#46; Prieto-Alhambra"
                            3 => "F&#46; Fina"
                            4 => "M&#46; Rosell"
                            5 => "T&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Inform Prim Care"
                        "fecha" => "2011"
                        "volumen" => "19"
                        "paginaInicial" => "135"
                        "paginaFinal" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22688222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity for use in research on vascular diseases of the SIDIAP &#40;Information System for the Development of Research in Primary Care&#41;&#58; the EMMA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Ramos"
                            1 => "E&#46; Ballo"
                            2 => "J&#46; Marrugat"
                            3 => "R&#46; Elosua"
                            4 => "J&#46; Sala"
                            5 => "M&#46; Grau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.recesp.2011.07.017"
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                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2012"
                        "volumen" => "65"
                        "paginaInicial" => "29"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22921172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Construcci&#243;n de un &#237;ndice de privaci&#243;n a partir de datos censales en grandes ciudades espa&#241;olas &#40;Proyecto MEDEA&#41;"
                      "autores" => array:1 [
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                            1 => "C&#46; Borrell"
                            2 => "G&#46; Cano-Serral"
                            3 => "S&#46; Esnaola"
                            4 => "A&#46; Nolasco"
                            5 => "M&#46;I&#46; Pasar&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Sanit"
                        "fecha" => "2008"
                        "volumen" => "22"
                        "paginaInicial" => "179"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18405568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0235"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prevalence of reduced glomerular filtration rate in older hypertensive patients and its association with cardiovascular disease&#58; a report from the <span class="elsevierStyleItalic">Antihypertensive and lipid-lowering treatment to prevent heart attack trial</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rahman"
                            1 => "C&#46;D&#46; Brown"
                            2 => "J&#46; Coresh"
                            3 => "B&#46;R&#46; Davis"
                            4 => "J&#46;H&#46; Eckfeldt"
                            5 => "N&#46; Kopyt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.164.9.969"
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                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2004"
                        "volumen" => "164"
                        "paginaInicial" => "969"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15136305"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CKD awareness and blood pressure control in the primary care hypertensive population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ravera"
                            1 => "G&#46; Noberasco"
                            2 => "U&#46; Weiss"
                            3 => "M&#46; Re"
                            4 => "A&#46;M&#46; Gallina"
                            5 => "A&#46; Filippi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.08.0222010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2011"
                        "volumen" => "57"
                        "paginaInicial" => "71"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21087817"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia de enfermedad renal cr&#243;nica en los hipertensos seguidos en los centros de salud de Espa&#241;a y grado de control de su presi&#243;n arterial &#40;estudio DISEHTAE&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Vara-Gonz&#225;lez"
                            1 => "E&#46; Mart&#237;n Riobo&#243;"
                            2 => "T&#46; Ure&#241;a Fern&#225;ndez"
                            3 => "A&#46; Dalf&#243; Baqu&#233;"
                            4 => "I&#46; Flor Becerra"
                            5 => "V&#46; L&#243;pez Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1157/13120016"
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                        "tituloSerie" => "Atenci&#243;n Primaria"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "241"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18482543"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Kidney function and cardiovascular disease in the hypertensive population&#58; the ERIC-HTA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Red&#243;n"
                            1 => "L&#46; Cea-Calvo"
                            2 => "J&#46;V&#46; Lozano"
                            3 => "C&#46; Fern&#225;ndez-P&#233;rez"
                            4 => "J&#46; Navarro"
                            5 => "A&#46; Bonet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.hjh.0000217848.10831.5f"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2006"
                        "volumen" => "24"
                        "paginaInicial" => "663"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16531794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences between office and 24-hour blood pressure control in hypertensive patients with CKD&#58; a 5693-patient cross-sectional analysis from Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Gorostidi"
                            1 => "P&#46; Sarafidis"
                            2 => "A&#46; de la Sierra"
                            3 => "J&#46; Segura"
                            4 => "J&#46;J&#46; de la Cruz"
                            5 => "J&#46;R&#46; Banegas"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "doi" => "10.1053/j.ajkd.2013.03.025"
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                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Prevalencia de enfermedad renal cr&#243;nica en mujeres hipertensas de edad avanzada atendidas en atenci&#243;n primaria&#46; Estudio MERICAP"
                      "autores" => array:1 [
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                            1 => "V&#46; Barrios Alonso"
                            2 => "A&#46; de la Sierra Iserte"
                            3 => "C&#46; Escobar Cervantes"
                            4 => "D&#46; Gonz&#225;lez-Segura Alsina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medcli.2011.03.038"
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                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2012"
                        "volumen" => "138"
                        "paginaInicial" => "512"
                        "paginaFinal" => "518"
                      ]
                    ]
                  ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of chronic kidney disease in population-based studies&#58; systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Q-L&#46; Zhang"
                            1 => "D&#46; Rothenbacher"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2458-8-117"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Public Health"
                        "fecha" => "2008"
                        "volumen" => "8"
                        "paginaInicial" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18405348"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                  ]
                ]
              ]
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              "identificador" => "bib0270"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Funci&#243;n renal y riesgo cardiovascular en pacientes con hipertensi&#243;n arterial esencial&#46; Estudio FRESHA"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Herrero"
                            1 => "R&#46; Mar&#237;n"
                            2 => "F&#46; Fern&#225;ndez Vega"
                            3 => "M&#46; Gorostidi"
                            4 => "A&#46; Riesgo"
                            5 => "J&#46; V&#225;zquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2006"
                        "volumen" => "26"
                        "paginaInicial" => "330"
                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16892821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic kidney disease in hypertension under specialist care&#58; the I-DEMAND study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "F&#46; Viazzi"
                            2 => "E&#46;A&#46; Rosei"
                            3 => "E&#46; Ambrosioni"
                            4 => "F&#46;V&#46; Costa"
                            5 => "G&#46; Leonetti"
                          ]
                        ]
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                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1097/HJH.0b013e328332038"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hypertens"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "paginaInicial" => "156"
                        "paginaFinal" => "162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19915481"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "24"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of kidney insufficiency in primary care population in Spain&#58; EROCAP study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;M&#46; De Francisco a"
                            1 => "J&#46;J&#46; de la Cruz"
                            2 => "A&#46; Cases"
                            3 => "M&#46; de la Figuera"
                            4 => "M&#46;I&#46; Egocheaga"
                            5 => "J&#46;I&#46; G&#243;rriz"
                          ]
                        ]
                      ]
                    ]
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                      "Revista" => array:6 [
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                        "paginaInicial" => "300"
                        "paginaFinal" => "312"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17725449"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left-ventricular hypertrophy and renal outcome in hypertensive patients in primary-care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ravera"
                            1 => "G&#46; Noberasco"
                            2 => "A&#46; Signori"
                            3 => "M&#46; Re"
                            4 => "A&#46; Filippi"
                            5 => "R&#46; Cannav&#242;"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ajh/hps100"
                      "Revista" => array:4 [
                        "tituloSerie" => "Am J Hypertens"
                        "fecha" => "2013"
                        "paginaInicial" => "700"
                        "paginaFinal" => "777"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0290"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and prognostic significance of chronic kidney disease in the elderly&#58; the three-city prospective cohort study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46; Metzger"
                            2 => "M&#46; Froissart"
                            3 => "M&#46; Rainfray"
                            4 => "C&#46; Berr"
                            5 => "C&#46; Tzourio"
                          ]
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                      ]
                    ]
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                        "tituloSerie" => "Nephrol Dial Transpl"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "3286"
                        "paginaFinal" => "3295"
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                    ]
                  ]
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                      "titulo" => "Urinary albumin excretion and glomerular filtration rate across the spectrum of glucose abnormalities in essential hypertension"
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                          "etal" => true
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                            3 => "M&#46; Brito"
                            4 => "J&#46; Mediavilla"
                            5 => "R&#46; Marin"
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                      "doi" => "10.1681/ASN.2006080920"
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                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "S236"
                        "paginaFinal" => "S245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17130268"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Relation between abdominal obesity&#44; insulin resistance and left ventricular hypertrophy diagnosed by electrocardiogram and magnetic resonance imaging in hypertensive patients"
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                          "etal" => true
                          "autores" => array:6 [
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                            3 => "M&#46;J&#46; Korndewal"
                            4 => "M&#46;L&#46; Bots"
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                      ]
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                        "paginaInicial" => "227"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22483385"
                            "web" => "Medline"
                          ]
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                        "tituloSerie" => "Am J Nephrol"
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                        "paginaInicial" => "399"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25401485"
                            "web" => "Medline"
                          ]
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                        "paginaFinal" => "2386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23137952"
                            "web" => "Medline"
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                          0 => array:2 [
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                            3 => "S&#46; Harris"
                            4 => "C&#46;W&#46; Mcintyre"
                            5 => "R&#46;J&#46; Fluck"
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                        "link" => array:1 [
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