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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sickle cell nephropathy is one of the complications of sickle cell disease &#40;SCD&#41;&#59; this is due to the polymerization of deoxygenated hemoglobin S in the renal medulla&#44; a place of special physiological conditions &#40;hyperosmolarity&#44; hypoxia and acidosis&#41;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> which contributes to the typical obstruction of vessels&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Chronic renal failure and proteinuria are the risk factors associated with increased mortality in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Albuminuria is the initial marker of SCD associated glomerulopathy&#44; the most frequent expression of which is focal and segmental glomerulosclerosis &#40;FSG&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a> Renal biopsy is indicated if glomerulopathy is suspected&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a 30-year-old white male&#44; with a history of homozygous sickle cell disease that was treated with hydroxyurea and deferasirox&#44; he develops 1&#8211;2 annual crises&#44; with no renal repercussions until present&#46; Smoker of 3 cigarettes per day&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was sent for consultation in relation of proteinuria of 2&#46;75<span class="elsevierStyleHsp" style=""></span>g in 24<span class="elsevierStyleHsp" style=""></span>h &#40;albuminuria&#58; 1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; The urine density was 1006&#44; pH&#58; 5&#46;5&#44; proteinuria 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and a normal sediment&#46; Renal function was normal &#40;Cr&#58; 0&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and MDRD<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#59; Hb&#58; 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#59; Hto&#58; 30&#37; &#40;TSI&#58; 80&#37;&#44; folic acid&#58; 8&#46;2<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#59; VitB&#58; 570<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41; and CRP&#58; 6&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46; The expanded study with autoimmunity and hepatitis C and B viruses as well as HIV is negative&#46; In abdominal ultrasound&#44; the kidneys do not have morphological abnormality and the spleen was small with diffuse increase of echogenicity suggesting fibrosis after repeated infarctions&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Once proteinuria was confirmed&#44; a renal biopsy was performed that showed glomerular hypertrophy without sclerosis&#44; enlargement of the glomerular capillaries and the presence of sickle cells within the capillaries &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The tubules have cells with haemosiderin by Perls staining and occasional areas of atrophy associated with fibrosis seen with trichrome staining &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41;&#46; Interstitial vessels do not reveal abnormalities and direct immunofluorescence shows absence of deposits&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The patient is diagnosed of sickle cell glomerulopathy&#46; After one year with valsartan&#44; 80<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; proteinuria decreased to 1&#46;6<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;albuminuria&#58; 1&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; and the mean blood pressure was 111&#47;63<span class="elsevierStyleHsp" style=""></span>mmHg by ABPM&#44; values did not allow an increase in doses of ARA-II or double blockage of the renin&#8211;angiotensin system due to risk of symptomatic hypotension&#46; At present&#44; renal function is maintained normal with Cr&#58; 0&#46;64<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;MDRD<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; CKD-EPI&#58; 130<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#44; serum phosphorus 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;tubular resorption phosphate&#58; 0&#46;9&#59; tubular reabsorption of urate&#58; 0&#46;9&#41; and urinary sediment continues to be normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Sickle cell disease is one of the most frequent hereditary hematological diseases&#44; and it is classified as one of the hemoglobinopathies&#46; This disease is caused by a point mutation that changes glutamine by valine in the globin gene on chromosome 11&#44; it generates hemoglobin S &#40;HbS&#41;&#44; which polymerizes in long fibers when deoxygenated&#44; this causes a decrease in erythrocyte deformability and produces cell membrane damage&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> It includes the homozygous state &#40;HbSS&#41;&#44; which is the most severe form and it is most frequently in African&#44; Mediterranean and Indian populations and the heterozygous forms HbSC and HbS-beta-thalassemia&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Renal involvement of sickle cell disease has a great variability&#46; Sickle cell nephropathy can range from difficulty of concentrating urine or hyposthenuria &#40;in our case the urine density was 1006&#41;&#44; to renal medullary carcinoma as the most extreme expression of severity&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A supranormal proximal tubular function may be present &#40;the patient has hyperphosphoremia and increased tubular phosphate reabsorption&#41;&#44; microhematuria&#44; microalbuminuria&#44; proteinuria of glomerular origin &#40;detected by Dipstick or more reliably by 24<span class="elsevierStyleHsp" style=""></span>h urine albuminuria&#41;&#44; hypertension&#44; acute renal failure and chronic renal failure&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Renal failure and glomerular proteinuria are risk factors associated with an increase in mortality in patients with sickle cell disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;10</span></a> It is estimated an overall mortality of 16&#8211;18&#37; attributed to renal disease&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In addition to the more frequent form of glomerulopathy &#40;FSG&#41;&#44; it may be manifested as membranoproliferative glomerulonephritis&#44; thrombotic microangiopathy and sickle cell-specific glomerulopathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;8</span></a> Biopsy is rarely used to establish the diagnosis&#59; in early sickle cell nephropathy&#44; glomerular hypertrophy is observed and is part of sickle cell disease description in 1960&#59; the most frequent location of glomerular hypertrophy is at the juxtaglomerular level&#44; in addition there is tubular hemosiderin deposits that play a relevant role in the progression of the nephropathy&#46; Other microscopy findings include red blood cell sickling in vasa recta&#44; capillary congestion&#44; mesangial expansion and endothelial lesion expressed as expansion of the lamina rara interna&#46; Renal biopsy is necessary in cases of significant proteinuria &#40;&#62;1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#41; or rapid deterioration of renal function that suggests glomerulonephritis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We conclude that the appearance of proteinuria in a patient with sickle cell disease should guide the existence of a sickle cell glomerulopathy where the glomerular hypertrophy is the consequence of an increased perfusion&#46; Nephrotic range proteinuria is associated with progression of CKD&#59; it is important to know the type of renal involvement given the high prevalence of glomerulopathy in adults with SCD&#44; for which the renal biopsy can help to mark the evolution and prognosis&#46;</p></span>"
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Letter to the Editor
Glomerular involvement in patient with sickle cell disease
Afectación glomerular en paciente con enfermedad falciforme
Roman Hernández-Gallegoa,
Corresponding author
romanhg78@hotmail.com

Corresponding author.
, Isis Cerezoa, Sergio Barrosoa, Lilia Azevedoa, María Lópezb, Nicolás Roberto Roblesa, Juan José Cuberoa
a Servicio de Nefrología, Hospital Universitario Infanta Cristina, Badajoz, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Infanta Cristina, Badajoz, Spain
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  "fechaPublicacion" => "2017-07-01"
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with a history of homozygous sickle cell disease that was treated with hydroxyurea and deferasirox&#44; he develops 1&#8211;2 annual crises&#44; with no renal repercussions until present&#46; Smoker of 3 cigarettes per day&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was sent for consultation in relation of proteinuria of 2&#46;75<span class="elsevierStyleHsp" style=""></span>g in 24<span class="elsevierStyleHsp" style=""></span>h &#40;albuminuria&#58; 1&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; The urine density was 1006&#44; pH&#58; 5&#46;5&#44; proteinuria 100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and a normal sediment&#46; Renal function was normal &#40;Cr&#58; 0&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and MDRD<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#59; Hb&#58; 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#59; Hto&#58; 30&#37; &#40;TSI&#58; 80&#37;&#44; folic acid&#58; 8&#46;2<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#59; VitB&#58; 570<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41; and CRP&#58; 6&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46; The expanded study with autoimmunity and hepatitis C and B viruses as well as HIV is negative&#46; In abdominal ultrasound&#44; the kidneys do not have morphological abnormality and the spleen was small with diffuse increase of echogenicity suggesting fibrosis after repeated infarctions&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Once proteinuria was confirmed&#44; a renal biopsy was performed that showed glomerular hypertrophy without sclerosis&#44; enlargement of the glomerular capillaries and the presence of sickle cells within the capillaries &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The tubules have cells with haemosiderin by Perls staining and occasional areas of atrophy associated with fibrosis seen with trichrome staining &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41;&#46; Interstitial vessels do not reveal abnormalities and direct immunofluorescence shows absence of deposits&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The patient is diagnosed of sickle cell glomerulopathy&#46; After one year with valsartan&#44; 80<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; proteinuria decreased to 1&#46;6<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;albuminuria&#58; 1&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; and the mean blood pressure was 111&#47;63<span class="elsevierStyleHsp" style=""></span>mmHg by ABPM&#44; values did not allow an increase in doses of ARA-II or double blockage of the renin&#8211;angiotensin system due to risk of symptomatic hypotension&#46; At present&#44; renal function is maintained normal with Cr&#58; 0&#46;64<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;MDRD<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; CKD-EPI&#58; 130<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#44; serum phosphorus 5<span class="elsevierStyleHsp" style=""></span>mg&#47;dl &#40;tubular resorption phosphate&#58; 0&#46;9&#59; tubular reabsorption of urate&#58; 0&#46;9&#41; and urinary sediment continues to be normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Sickle cell disease is one of the most frequent hereditary hematological diseases&#44; and it is classified as one of the hemoglobinopathies&#46; This disease is caused by a point mutation that changes glutamine by valine in the globin gene on chromosome 11&#44; it generates hemoglobin S &#40;HbS&#41;&#44; which polymerizes in long fibers when deoxygenated&#44; this causes a decrease in erythrocyte deformability and produces cell membrane damage&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> It includes the homozygous state &#40;HbSS&#41;&#44; which is the most severe form and it is most frequently in African&#44; Mediterranean and Indian populations and the heterozygous forms HbSC and HbS-beta-thalassemia&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Renal involvement of sickle cell disease has a great variability&#46; Sickle cell nephropathy can range from difficulty of concentrating urine or hyposthenuria &#40;in our case the urine density was 1006&#41;&#44; to renal medullary carcinoma as the most extreme expression of severity&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A supranormal proximal tubular function may be present &#40;the patient has hyperphosphoremia and increased tubular phosphate reabsorption&#41;&#44; microhematuria&#44; microalbuminuria&#44; proteinuria of glomerular origin &#40;detected by Dipstick or more reliably by 24<span class="elsevierStyleHsp" style=""></span>h urine albuminuria&#41;&#44; hypertension&#44; acute renal failure and chronic renal failure&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Renal failure and glomerular proteinuria are risk factors associated with an increase in mortality in patients with sickle cell disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;10</span></a> It is estimated an overall mortality of 16&#8211;18&#37; attributed to renal disease&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In addition to the more frequent form of glomerulopathy &#40;FSG&#41;&#44; it may be manifested as membranoproliferative glomerulonephritis&#44; thrombotic microangiopathy and sickle cell-specific glomerulopathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;8</span></a> Biopsy is rarely used to establish the diagnosis&#59; in early sickle cell nephropathy&#44; glomerular hypertrophy is observed and is part of sickle cell disease description in 1960&#59; the most frequent location of glomerular hypertrophy is at the juxtaglomerular level&#44; in addition there is tubular hemosiderin deposits that play a relevant role in the progression of the nephropathy&#46; Other microscopy findings include red blood cell sickling in vasa recta&#44; capillary congestion&#44; mesangial expansion and endothelial lesion expressed as expansion of the lamina rara interna&#46; Renal biopsy is necessary in cases of significant proteinuria &#40;&#62;1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#41; or rapid deterioration of renal function that suggests glomerulonephritis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We conclude that the appearance of proteinuria in a patient with sickle cell disease should guide the existence of a sickle cell glomerulopathy where the glomerular hypertrophy is the consequence of an increased perfusion&#46; Nephrotic range proteinuria is associated with progression of CKD&#59; it is important to know the type of renal involvement given the high prevalence of glomerulopathy in adults with SCD&#44; for which the renal biopsy can help to mark the evolution and prognosis&#46;</p></span>"
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Article information
ISSN: 20132514
Original language: English
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2021 August 33 39 72
2021 July 39 33 72
2021 June 29 34 63
2021 May 46 40 86
2021 April 104 64 168
2021 March 65 37 102
2021 February 34 28 62
2021 January 44 24 68
2020 December 28 17 45
2020 November 33 16 49
2020 October 27 21 48
2020 September 28 11 39
2020 August 37 10 47
2020 July 34 12 46
2020 June 28 18 46
2020 May 39 13 52
2020 April 30 16 46
2020 March 34 18 52
2020 February 42 18 60
2020 January 33 21 54
2019 December 57 23 80
2019 November 35 19 54
2019 October 35 12 47
2019 September 36 16 52
2019 August 38 14 52
2019 July 25 17 42
2019 June 37 17 54
2019 May 30 10 40
2019 April 90 29 119
2019 March 44 26 70
2019 February 37 16 53
2019 January 39 29 68
2018 December 164 38 202
2018 November 285 20 305
2018 October 183 25 208
2018 September 102 16 118
2018 August 64 10 74
2018 July 54 10 64
2018 June 72 8 80
2018 May 67 16 83
2018 April 197 11 208
2018 March 100 14 114
2018 February 65 6 71
2018 January 84 13 97
2017 December 80 4 84
2017 November 62 8 70
2017 October 51 8 59
2017 September 53 19 72
2017 August 57 15 72
2017 July 34 6 40
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?