Statistics

 array:25 [
  "pii" => "S2013251417300834"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2017.04.011"
  "estado" => "S300"
  "fechaPublicacion" => "2017-03-01"
  "aid" => "311"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2017;37:172-80"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5543
    "formatos" => array:3 [
      "EPUB" => 356
      "HTML" => 4466
      "PDF" => 721
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699516302053"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2016.10.026"
      "estado" => "S300"
      "fechaPublicacion" => "2017-03-01"
      "aid" => "311"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2017;37:172-80"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 16274
        "formatos" => array:3 [
          "EPUB" => 360
          "HTML" => 14558
          "PDF" => 1356
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Estimaci&#243;n del filtrado glomerular en personas mayores de 85 a&#241;os&#58; comparaci&#243;n de las ecuaciones CKD-EPI&#44; MDRD-IDMS y BIS1"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "172"
            "paginaFinal" => "180"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Glomerular filtration rate estimation in people older than 85&#58; Comparison between CKD-EPI&#44; MDRD-IDMS and BIS1 equations"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 3417
                "Ancho" => 1484
                "Tamanyo" => 341179
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Diagramas de Bland-Altman BIS1-MDRD4-IDMS&#46;</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos Bland-Altman en los que se muestra las diferencias en FGe mediante las f&#243;rmulas A&#41; MDRD4-IDMS y CKDEPI&#59; B&#41; MDRD4-IDMS y BIS1 y C&#41; CKDEPI y BIS1&#46; Todos los datos se expresan en mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span>&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Fernando Bustos-Guada&#241;o, Jos&#233; Luis Mart&#237;n-Calder&#243;n, Juan Jos&#233; Criado-&#193;lvarez, Raquel Mu&#241;oz-Jara, Adolfo Cantalejo-Guti&#233;rrez, Mar&#237;a Concepci&#243;n Mena-Moreno"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Fernando"
                "apellidos" => "Bustos-Guada&#241;o"
              ]
              1 => array:2 [
                "nombre" => "Jos&#233; Luis"
                "apellidos" => "Mart&#237;n-Calder&#243;n"
              ]
              2 => array:2 [
                "nombre" => "Juan Jos&#233;"
                "apellidos" => "Criado-&#193;lvarez"
              ]
              3 => array:2 [
                "nombre" => "Raquel"
                "apellidos" => "Mu&#241;oz-Jara"
              ]
              4 => array:2 [
                "nombre" => "Adolfo"
                "apellidos" => "Cantalejo-Guti&#233;rrez"
              ]
              5 => array:2 [
                "nombre" => "Mar&#237;a Concepci&#243;n"
                "apellidos" => "Mena-Moreno"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2013251417300834"
          "doi" => "10.1016/j.nefroe.2017.04.011"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300834?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516302053?idApp=UINPBA000064"
      "url" => "/02116995/0000003700000002/v1_201704211146/S0211699516302053/v1_201704211146/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2013251417300500"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.02.008"
    "estado" => "S300"
    "fechaPublicacion" => "2017-03-01"
    "aid" => "323"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:181-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3603
      "formatos" => array:3 [
        "EPUB" => 310
        "HTML" => 2588
        "PDF" => 705
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "The incidence of new onset diabetes after transplantation and related factors&#58; Single center experience"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "181"
          "paginaFinal" => "188"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Incidencia de diabetes postrasplante de nueva aparici&#243;n y factores relacionados&#58; experiencia de un &#250;nico centro"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ayse Sinangil, Vedat Celik, Soykan Barlas, Yener Koc, Taner Basturk, Tamer Sakaci, Emin Baris Akin, Tevfik Ecder"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Ayse"
              "apellidos" => "Sinangil"
            ]
            1 => array:2 [
              "nombre" => "Vedat"
              "apellidos" => "Celik"
            ]
            2 => array:2 [
              "nombre" => "Soykan"
              "apellidos" => "Barlas"
            ]
            3 => array:2 [
              "nombre" => "Yener"
              "apellidos" => "Koc"
            ]
            4 => array:2 [
              "nombre" => "Taner"
              "apellidos" => "Basturk"
            ]
            5 => array:2 [
              "nombre" => "Tamer"
              "apellidos" => "Sakaci"
            ]
            6 => array:2 [
              "nombre" => "Emin Baris"
              "apellidos" => "Akin"
            ]
            7 => array:2 [
              "nombre" => "Tevfik"
              "apellidos" => "Ecder"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300500?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000002/v1_201705250045/S2013251417300500/v1_201705250045/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251417300743"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2017.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2017-03-01"
    "aid" => "252"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2017;37:164-71"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4076
      "formatos" => array:3 [
        "EPUB" => 381
        "HTML" => 3079
        "PDF" => 616
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Atlas of systematic variation in renal replacement therapy in Catalonia &#40;2002&#8211;2012&#41;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "164"
          "paginaFinal" => "171"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Atlas de variaciones sistem&#225;ticas en el tratamiento sustitutivo renal en Catalu&#241;a &#40;2002&#8211;2012&#41;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Fig&#46; 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1156
              "Ancho" => 1653
              "Tamanyo" => 63307
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Crude cumulative incidence rates of renal replacement therapy with peritoneal dialysis by age group and gender &#40;2002&#8211;2012&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Cristian Teb&#233; Condom&#237;, Emma Arcos, Jordi Comas, Mireia Espallargues, Joan M&#46;V&#46; Pons, Joan M&#46; D&#237;az, Jaume Tort, Alberto Martinez-Castelao"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Cristian"
              "apellidos" => "Teb&#233; Condom&#237;"
            ]
            1 => array:2 [
              "nombre" => "Emma"
              "apellidos" => "Arcos"
            ]
            2 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Comas"
            ]
            3 => array:2 [
              "nombre" => "Mireia"
              "apellidos" => "Espallargues"
            ]
            4 => array:2 [
              "nombre" => "Joan M&#46;V&#46;"
              "apellidos" => "Pons"
            ]
            5 => array:2 [
              "nombre" => "Joan M&#46;"
              "apellidos" => "D&#237;az"
            ]
            6 => array:2 [
              "nombre" => "Jaume"
              "apellidos" => "Tort"
            ]
            7 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Martinez-Castelao"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699516301175"
        "doi" => "10.1016/j.nefro.2016.08.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516301175?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300743?idApp=UINPBA000064"
    "url" => "/20132514/0000003700000002/v1_201705250045/S2013251417300743/v1_201705250045/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Estimation of the glomerular filtration rate in people older than 85&#58; Comparisons between CKD-EPI&#44; MDRD-IDMS and BIS1 equations"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "172"
        "paginaFinal" => "180"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Fernando Bustos-Guada&#241;o, Jos&#233; Luis Mart&#237;n-Calder&#243;n, Juan Jos&#233; Criado-&#193;lvarez, Raquel Mu&#241;oz-Jara, Adolfo Cantalejo-Guti&#233;rrez, Mar&#237;a Concepci&#243;n Mena-Moreno"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Fernando"
            "apellidos" => "Bustos-Guada&#241;o"
            "email" => array:1 [
              0 => "fjbustox&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233; Luis"
            "apellidos" => "Mart&#237;n-Calder&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan Jos&#233;"
            "apellidos" => "Criado-&#193;lvarez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Raquel"
            "apellidos" => "Mu&#241;oz-Jara"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Adolfo"
            "apellidos" => "Cantalejo-Guti&#233;rrez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Mar&#237;a Concepci&#243;n"
            "apellidos" => "Mena-Moreno"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de An&#225;lisis Cl&#237;nicos&#44; Hospital Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Centro de Salud de San Bartolom&#233; de las Abiertas&#44; Toledo&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Centro de Salud la Solana&#44; Talavera de la Reina&#44; Toledo&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Estimaci&#243;n del filtrado glomerular en personas mayores de 85 a&#241;os&#58; comparaci&#243;n de las ecuaciones CKD-EPI&#44; MDRD-IDMS y BIS1"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2513
            "Ancho" => 3306
            "Tamanyo" => 295793
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Rectas de regresi&#243;n de Passing-Bablock de las ecuaciones de filtrado glomerular&#46; Rectas de regresi&#243;n de Passing-Bablok entre las distintas ecuaciones para la estimaci&#243;n del filtrado glomerular&#46; &#40;A&#41; Recta de regresi&#243;n MDRD4-IDMS-CKDEPI&#46; &#40;B&#41; Recta de regresi&#243;n BIS1-CKDEPI&#46; &#40;C&#41; Recta de regresi&#243;n&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic renal failure is health problem worldwide and the prevalence increases with the aging of the population&#46; According to a epidemiological study in Spain &#8220;Epidemiology of chronic renal failure in Spain &#40;EPIRCE&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">1</span></a> a 6&#46;8&#37; of the adult population has CKD with a GFR &#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#59; if the population selected is &#62;64 year the prevalence of CKD increases to 21&#46;4&#37;&#46; The estimation of the GFR &#40;eGFR&#41; using formulas based on the values of serum creatinine concentration are the widely used to detect CKD in the entire population&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Screening for CKD is made by estimation of GFR&#44; based in several equations that use values of serum creatinine &#40;Cr&#41; concentration&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">2</span></a> and the measurement the albumin&#47;Cr ratio in urine&#46; This method is being recommended by the Spanish Society of Clinical Chemistry and Molecular Pathology&#44; the Spanish Society Of Nephrology and The Spanish Society of Primary Care Medicine&#46; The most common equations utilized for estimation of GFR are&#58; MDRD-IDMS &#40;<span class="elsevierStyleItalic">Modification of Diet in Renal Disease</span> which includes 4 variables&#41;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">3</span></a> and the CKD-EPI &#40;<span class="elsevierStyleItalic">Chronic Kidney Disease Epidemiology Collaboration</span> which depends on the serum values of Cr&#41;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">4</span></a> Also it is recommended to use the criteria of National Kidney Foundation Kidney Disease Outcomes Quality Initiative &#40;NKF-KDOQI&#41;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">5</span></a> to detect CKD in the entire population including young and aged individuals&#46; Values of estimated GFR &#40;eGFR&#41; &#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> are contemplated CKD but it should be contemplated that the GFR decreases with age in a physiological manner&#46; From age 30 to 70 the GFR decreases 0&#46;8<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#47;year and from age 70 the decline is 1&#46;05<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#47;year&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> Thus it is important to take into consideration other parameters such as albuminuria&#44; anemia&#44; hyperphosphatemia&#44; abnormalities of the urine sediment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">There reports on CKD screening in population of individuals 60&#8211;80 y&#46;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">7&#8211;9</span></a> using equations to calculate eGFR based on serum Cr&#46; Information about the use of these equations in individuals &#62;85 years of age is limited&#59; the diet&#44; weight and body surface<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">10</span></a> are different in elderly and younger people&#46; The study by G&#243;mez-Pav&#243;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">9</span></a> in 70 patents &#62;75 y&#46;o&#46; concludes that the values of eGFR obtained by the MDRD-IDMS are not the same as eGFR corrected by body surface or the estimated by the Cockcroft&#8211;Gault equation&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">9</span></a> The MDRD-IDMS<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">3</span></a> equation is not valid for people &#62;72 y&#46;o&#46; and it was generated using only individuals with CKD&#46; The formula CKD-EPI&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">4</span></a> developed in 2009&#44; it is more precise and was generated based in a population with GFR &#62;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; it is better than MDRD-IDMS to separate patients in the different stages of CKD&#46; Furthermore&#44; as compared with MDRD-IDMS&#44; the CKD-EPI correlates better with direct measurements of GFR such as creatinine clearance and iothalamate clearance&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">4</span></a> and this is true also in elderly people<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">11</span></a>&#59; a limitation of the CKD-EPI is that the evaluation was done only in 28 patients older that 80 in a total population of 5504 individuals&#46; In the year 2012 the Berlin <span class="elsevierStyleItalic">Initiative Study</span> generated two new equations &#40;BIS1 and BIS2&#41; based in a sample of 570 patients &#62;70 y&#46;o&#46; The BIS1 equation includes serum Cr&#44; age and gender and the BIS2 includes also cystatin C&#46; As compared with BIS1&#44; BIS2 correlates with the measurement of GFR &#40;plasma clearance of iohexol&#41;&#44; but in people &#62;70 y&#46;o&#46; it is recommended to use BIS1 if the measurement of cystatin C is not available&#44; although results from external validation of this equation are not homogeneous&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">13&#44;14</span></a> As far as the measurement of GFR by calculating the Cr clearance it should be pointed out that there is tubular secretion of Cr leading to overestimation of the GFR and this tubular secretion of Cr is increased as the GFR declines&#59; furthermore and elderly individual had more difficulties to collect urine during 24<span class="elsevierStyleHsp" style=""></span>h&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of the present study is to compare the results obtained using the 3 different equations to estimate GFR&#58; CKD-EPI&#44; BIS1 and MDRD-IDMS&#44; in patients &#62;85 y&#46;o&#46; attending out patient primary care or specialized clinics&#46; Will also analyze if the method to estimate GFR has an impact in the classification of patients in the different stages of CKD&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and method</span><p id="par0025" class="elsevierStylePara elsevierViewall">This is a retrospective transversal study including patient&#39;s data from January 2009 to May 2015&#46; There were 600 patients &#62;80 y&#46;o&#46; with a determination of serum Cr that were seen in outpatient clinics of the Nuestra Se&#241;ora del Prado de Talavera de la Reina Hospital or primary care centers of the area&#46; Data was collected with the help of the information system Omega 3000 &#40;Roche Diagnostic<span class="elsevierStyleSup">&#174;</span>&#41;&#46; The following variables were collected&#58; age&#44; gender&#44; serum Cr biochemistry was measured by autoanalyzer Cobas 711 &#40;Roche Diagnostic<span class="elsevierStyleSup">&#174;</span>&#41;&#46; The serum Cr was quantified by compensated kinetic Jaff&#233; method which offers direct traceability and calibration against the reference method <span class="elsevierStyleItalic">isotope dilution mass spectrometry</span> &#40;ID&#47;MS&#41;&#46; Reference values of serum Cr with this method are &#60;0&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL for females and &#60;1&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL for males&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The eGFR was calculated using the equations MDRD-IDMS&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">3</span></a> CKD-EPI<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">4</span></a> and BIS1&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">12</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Equations used to calculate the eGFR &#40;mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="eq0005"></elsevierMultimedia></p><p id="par0040" class="elsevierStylePara elsevierViewall">eGFR units&#58; mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#59; serum Cr units&#58; mg&#47;dL&#59; and age in years&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The CKD stages were established according to the criteria of the Kidney Disease Improving Global Outcomes &#40;KDIGO&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of the Hospital &#8220;Nuestra Se&#241;ora del Prado de Talavera de la Reina &#40;Toledo&#41;&#8221;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Variables were recorded in Excel 2007 to be subsequently analyzed with SPSS v15&#44; Epidat 4&#46;1 and Med-Calc v 11&#46;3&#46; Age&#44; Cr and eGFR did not follow a normal distribution &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; test de Shapiro&#8211;Wilk&#41;&#44; so means were compared by the non-parametric Wilcoxon test&#46; Qualitative variables are expressed as frequency and percentage&#59; quantitative variables are expressed as median&#44; mean and interval&#46; The degree agreement between equations was evaluated by non-parametric regression test of Passing and Bablok<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">15</span></a> and the Pearson correlation&#46; The prevalence of the different CKD stages for the 3 methods of eGFR was determined&#59; and the agreement between the different methods was evaluated by the weighted &#8220;<span class="elsevierStyleItalic">&#954;</span>&#8221; index the gross agreement&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Bland&#8211;Altman<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">16</span></a> graphs were obtained to estimate deviation among the 3 eGFRs&#46; Significance was accepted if <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">Sample size is 600&#44; 272 males &#40;45&#46;3&#37;&#41;&#44; median age 87 &#40;interval&#58; 85&#8211;98&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the medians of Cr and of the eGFR by the 3 equations separated by gender and serum Cr&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the medians of Cr and of the eGFR by CKD-EPI and MDRD-IDMS and the comparison with BIS1&#46; The values obtained with BIS1 are significantly reduced as compared with MDRD-IDMS and CKD-EPI&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Classifications of CKD stages using BIS1 relative to MDRD-IDMS and CKD-EPI are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The estimation of GFR by BIS1 equation modifies the CKD classification in 248 &#40;41&#46;3&#37;&#41; and 188 &#40;31&#46;3&#37;&#41; with respect to the equations MDRD-IDMS and CKD-EPI respectively&#59; this difference mainly concerns to stage 3b as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Using the equation BIS1&#44; 568&#47;600 &#40;94&#46;6&#37;&#41; of the individuals present a eGFR &#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#59; this number changes to 494&#47;600 &#40;82&#46;3&#37;&#41; if GFR is calculated using the formula MDRD-IDMS and it changes to 505&#47;600 &#40;84&#46;2&#37;&#41; if calculation is made with the CKD-EPI equation&#46; If&#44; as other author suggest&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">17</span></a> the cutting value for CKD is set at eGFR 38<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> the prevalence of CKD is 44&#46;4&#37; according to CKD-EPI&#44; 54&#46;3 using BIS1 and 38&#46;3&#37; if the calculation are made using MDRD-IDMS formula&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The analysis of agreement between MDRD-IDMS and CKD-EPI reveals a value of weighted kappa of 0&#46;958 &#40;95&#37; CI&#58; 0&#46;948&#8211;0&#46;968&#41;&#44; while with the BIS1 equation the value of weighted kappa is 0&#46;812 &#40;95&#37; CI&#58; 0&#46;789&#8211;0&#46;936&#41; and 0&#46;846 &#40;95&#37; CI&#58; 0&#46;824&#8211;0&#46;866&#41;&#44; as compared with MDRD-IDMS and CKD-EPI&#44; respectively&#46; The degree of agreement between MDRD-IDMS and CKD-EPI was 89&#46;2&#37;&#44; between BIS1 and MDRD-IDMS 59&#46;1&#37; and between BIS1 and CKD-EPI 68&#46;5&#37;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Among the subjects that were changed of CKD stage after estimation by BIS1 with respect to MDRD-IDMS&#44; 232 &#40;38&#46;6&#37;&#41; were change to one stage superior and 2 &#40;03&#37;&#41; were changed to 2 stages above the initial&#59; 14 individuals &#40;2&#46;3&#37;&#41; were reclassified to a lower stage of CKD&#46; The most numerous changes were observed in stage 3a with 120 individuals &#40;74&#46;5&#37;&#41; being changed to stage 3b after application of the BIS1&#46; With the use of CKD-EPI equation&#44; 172 &#40;28&#46;6&#37;&#41; subjects were changed to a superior stage and 16 &#40;2&#46;6&#37;&#41; to a inferior stage&#46; Most changes concerned to stage 3a&#44; in which 106 &#40;68&#46;3&#37;&#41; were changed to stage 3b&#46; In relation to MDRD-IDMS&#44; the equation CKD-EPI change 66 &#40;11&#37;&#41; subjects to a superior stage and none to an inferior stage&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The Passing&#8211;Bablok regression &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; including the different GFR equations produced the following results&#58; MDRD-IDMS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;025<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI &#40;95&#37; CI&#58; 1&#46;019&#8211;1&#46;030&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1&#46;36 &#40;95&#37; CI&#58; 1&#46;152&#8211;1&#46;568&#41; with a correlation coefficient <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;990 &#40;95&#37; CI&#58; 0&#46;989&#8211;0&#46;992&#41;&#59; BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;688<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI &#40;95&#37; CI&#58; 0&#46;682&#8211;0&#46;694&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>9&#46;074 &#40;95&#37; CI&#58; 8&#46;843&#8211;9&#46;318&#41; with <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;993 &#40;95&#37; CI&#58; 0&#46;992&#8211;0&#46;994&#41; and BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;666<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>MDRD-IDMS &#40;95&#37; CI&#58; 0&#46;659&#8211;0&#46;673&#41;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>8&#46;401 &#40;95&#37; CI&#58; 8&#46;100&#8211;8&#46;659&#41; with <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;992 &#40;95&#37; CI&#58; 0&#46;991&#8211;0&#46;994&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The results of Bland&#8211;Altman test are shown in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> and <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#46; Comparison of MDRD-IDMS and CKD-EPI is shown in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>a&#59; from values above eGFR of 75&#8211;80<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> there an increased dispersion but there differences were homogenous up to that value&#46; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>b shows that a difference between the two estimations of GFR increases with the value of GFR throughout the entire range of values&#44; while in <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>c this increase is observed until eGFR values of 75&#8211;80<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">The GFR is the best method to assess renal function and it is necessary for a correct use of the dose of medication&#46; In clinical practice there are several formulas available for the calculation of GFR<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">18</span></a> so the 24<span class="elsevierStyleHsp" style=""></span>h urine collection is avoided&#44; such a procedure is not easy in this population&#46; Recently&#44; Schaeffner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">12</span></a> had developed 2 new equations&#44; BIS1 and BIS2&#44; to obtain better estimation of GFR in people older that 70 years&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Lopes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">19</span></a> shows that the equation BIS1 is more exact than the MDRD-IDMS and CKD-EPI in patients older that 80 years with a GFR &#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In our study we have compared BIS with MDRD-IDMS and CKD-EPI in patients older than 85 years&#46; The equation BIS1 and the BIS2 were obtained from a population &#62;70 years with a mean of 78&#46;5 years of age&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In our study we have found that GFR calculated by BIS1 is lower than with MDRD-IDMS and CKD-EPI&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows that the values of eGFR obtained using the BIS1 equation in people with serum Cr below the reference values are similar independent of gender and the values are lower than those obtained with the equations MDRD-IDMS and CKD-EPI&#46; Besides&#44; there is less dispersion of eGFR calculated with BIS1 since the sample used to develop BIS1 is similar to that presented in this study&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As compared with MDRD-IDMS&#44; la difference of the means is 7&#46;7<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> &#40;18&#37;&#41; and with CKD-EPI the difference is 4&#46;23<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> &#40;10&#37;&#41;&#46; As compared with the results reported by Schaeffner et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">12</span></a> the differences are similar for MDRD-IDMS &#40;19&#46;6&#37;&#41; but are less for CKD-EPI &#40;19&#46;6&#37;&#41;&#46; In the study by Koppe et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> with 224 patients and a mean age of 75&#46;3 years the difference between values obtained with BIS1 and both MDRD-IDMS and CKD-EPI were similar &#40;7 and 5&#37;&#44; respectively&#41;&#46; These results are not the same as ours&#44; and the explanation could be that the sample is size different and our population is older&#46; Considering these differences&#44; estimations with BIS1 results in a greater proportion of patients with severe CKD since there will be more patients allocated to stages 3b and 4&#46; This change in the classification of the CKD stage is supported by the fact that in people with eGFR &#60;30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> there is a better correlation between BIS1equation and the gold standard GFR<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> measurement than between the CKD-EPI and MDRD-IDMS and the gold standard GFR&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Our study shows that the use of BIS1 produces some differences in the population older than 85 years&#46; With this age&#44; the values of eGFR using BIS1 are reduced as compared with CKD-EPI if the GFR is less than 29<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; Therefore using BIS1 the prevalence of CKD in this population increases independently of whether the limit for CKD is set at 60 or 38<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">17&#44;21</span></a> With the use of the formula BIS1the prevalence of CKD &#40;GFR &#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#41; would be increased a 11 and a 12&#46;6&#37; as compared with the CKD-EPI and MDRD-IDMS methods respectively&#46; If CKD is considered with a GFR &#60;38<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> the respective increase in prevalence would be 8&#46;5&#37; and 15&#46;4&#37;&#46; Using the formula BIS1 the percent of patients with eGFR less than 30<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> being sent to nephrologists from primary health care doctors will be 26&#46;5&#37; which is not different with respect to CKD-EPI but it is greater than MDRD-IDMS &#40;22&#46;8&#37;&#41;&#59; this difference of 4&#37; is less than the values obtained &#40;12&#37;&#41; in another study performed in Spain<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">22</span></a> although the patients in this study were &#62;70 years&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">There is an acceptable agreement between values obtained with CKD-EPI and MDRD-IDMS and patients are classified within the same CKD stage which confirms previous results&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">23&#44;24</span></a> In general the values obtained with CKD-EPI are lower than with MDRD-IDMS so patients are reclassified to a superior stage of CKD&#44; this is similar to other reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">25&#44;26</span></a> Although the percent of patients reclassified is only 11&#37; it is greater than the 2&#46;6&#37; obtained in another study<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> that included 20&#46;000 subjects with a mean age of 73&#46;5&#46; The values of weighted <span class="elsevierStyleItalic">&#954;</span> index from BIS1 equation vs MDRD-IDMS and CKD-EPI are not very low &#40;<span class="elsevierStyleItalic">&#954;</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;8&#41;&#44; but the values obtained after analysis of gross agreement are clinically unacceptable since a large number of patients are reclassified&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The Passing&#8211;Bablok linear correlation analysis shows a constant and proportional with respect to MDRD-IDMS and CKD-EPI&#59; thus&#44; the results obtained with these two equation is not exchangeable results obtained BIS1&#46; The BIS1 derived values are inferior to the obtained with CKD-EPI and MDRD-IDMS in patients with a GFR lower than 25<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; This is also illustrated in the Bland&#8211;Altman graphs which reveal that the greater the GFR&#44; the larger the difference between values of BIS1 vs CKD-EPI and MDRD-IDMS&#46; These results are in agreement with other reports showing that MDRD-IDMS and CKD-EPI overestimate the GFR with respect to as direct gold standard GFR measurements mainly if GFR is above 60<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and patients are &#62;70 y&#46;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">12&#44;13&#44;20</span></a> In addition dispersion of values analyzed by Bland&#8211;Altman test are&#44; in both cases&#44; too large from a clinical point of view&#46; The observed differences in the regression lines and in the Bland&#8211;Altman graph indicate that it is necessary to modify the reference values if calculation of GFR are made with BIS1 in a elderly population without a renal disease&#46; In this group of patients there is also a moderate overestimation of GFR by MDRD-IDMS as compared with CKD-EPI&#46; This slight difference seen in people &#62;85 y&#46;o&#46; is in contrast with other reports in younger patients in which the difference is greater<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">27</span></a> and it is not no longer evident in people older that 70 years&#46; We believe that similarities between our values and MDRD-IDM are due to the fact that the MDRD-IDMS equation was developed in a population with reduced GFR&#58; mean 40<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> which is similar to the population evaluated in he present study&#46; The CKD-EPI equation was developed from a population with higher GFR and even with normal GFR&#46; In fact the Bland&#8211;Altman graph shows greater dispersion if GFR is greater than 80<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Limitations of this study include the fact that it does not represent the general population because the subjects included in the study came from primary care and specialized out patients clinics from a single health care area&#46; In some patients&#44; established renal disease was suspected&#46; Estimation of the number of consultations to nephrologists was based on eGFR&#59; albuminuria&#44; anemia&#44; hematuria&#44; abnormal sediment or changes in parameters of mineral metabolism were not taken into consideration for this calculation&#46; The equation developed in the work of Schaeffner et al&#46; was based in a population with a high percentage of hypertension &#40;76&#46;1&#37;&#41; and diabetes mellitus &#40;24&#37;&#41;&#59; we do not have information on the prevalence of diabetes mellitus and hypertension or the treatment received which is important in elderly people&#46; The serum level of cystatin was not available therefore it was not possible to estimate GFR by the BIS2 formula&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">As a conclusion&#44; in people older than 85 years the calculation of GFR using different equations are not interchangeable from one method to another&#46; The regular use of the BIS1 formula in people more that 85 y&#46;o&#46; result in values of eGFR lower that those obtained with MDRD-IDMS or CKD-EPI&#44; consequently the prevalence of CKD will appear to be increased&#46; The MDRD-IDMS or CKD-EPI methods overestimate the eGFR with respect to BIS1 due to the reduction of lean body mass that occurs in senescence&#46; These values of eGFR may cause changes in the dose adjustment in some medication to avoid overdose that could occur if the other two equations are applied&#46; It is observed that with the use of BIS1 patients are classified with more severe CKD stage&#44; particularly from patients stage 2 are changed to 3a and from 3a to 3b&#46; Since results from BIS1&#44; MDRD-IDMS and CKD-EPI are not interchangeable it is necessary to establish new reference values of GFR for elderly people more than 70 years old if eGFR is calculated with the BIS1 equation&#59; it is also needed to establish limits of GFR to define CKD in the elderly&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare not to have any potential conflict of interest in relation to the content of the present article&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres842784"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Patients and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec837992"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres842783"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Pacientes y m&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec837993"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Patients and method"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Equations used to calculate the eGFR &#40;mL&#47;min&#47;1&#46;73 m&#41;"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflict of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-11-12"
    "fechaAceptado" => "2016-10-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec837992"
          "palabras" => array:6 [
            0 => "Renal glomerular filtration"
            1 => "Aged"
            2 => "Aged 85 and over"
            3 => "MDRD-IDMS"
            4 => "CKD-EPI"
            5 => "BIS1"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec837993"
          "palabras" => array:6 [
            0 => "Filtrado glomerular renal"
            1 => "Ancianos"
            2 => "Mayores de 85 a&#241;os"
            3 => "MDRD-IDMS"
            4 => "CKD-EPI"
            5 => "BIS1"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The evidence of glomerular filtration rate &#40;GFR&#41; estimating with serum creatinine based formulae in the elderly population is scarce&#46; The purpose of this study is to compare CKD-EPI&#44; MRD4-IDMS and BIS1 equations to analyze correlation and concordance in a population older than 85 years old&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We designed a retrospective cross-sectional study&#44; which included data from 600 patients older than 85 years&#46; GFR was estimated by the following equations&#58; CKD-EPI&#44; MDR4-IDMS and BIS1&#44; using as variables sex&#44; age and serum creatinine concentration&#46; Statistics analysis included Wilcoxon test&#44; Bland&#8211;Altman plot&#44; non-parametric Passing&#8211;Bablok method and kappa statistic &#40;simple and weighted&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients&#8217; median &#40;range&#41; age was 87 &#40;interval 85&#8211;98&#41;&#46; The median GFR &#40;range&#41; was 42&#46;4 &#40;5&#46;2&#8211;127&#46;4&#41;<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; when it was estimated with MDRD-IDMS&#44; 40&#46;0 &#40;4&#46;5&#8211;93&#46;1&#41; for CKD-EPI and 36&#46;9 &#40;7&#46;6&#8211;83&#46;7&#41; for BIS1&#46; The comparison of BIS1 and CKD-EPI and MDRD-IDMS using the Wilcoxon test was significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; The regression analysis yielded the following equations&#58; MDRD-IDMS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;025<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1&#46;360&#59; BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;688<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>9&#46;074 and BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;666<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>MDRD-IDMS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>8&#46;401&#46; The weighted coefficient was 0&#46;958 for the concordance between MDRD-IDMS and CKD-EPI&#44; 0&#46;812 for the concordance between MDRD-IDMS and BIS1 and 0&#46;846 for CKD-EPI and BIS1&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The GFR estimations obtained with BS1 equation are not interchangeable with MDRD-IDMS or CKD-EPI equations&#46; BIS1 estimates lower GFR values than MDRD-IDMS and CKD-EPI and tends to classify the patients in a more advanced chronic kidney disease stage&#44; especially for estimated GFR higher than 29<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Patients and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La estimaci&#243;n del filtrado glomerular &#40;FG&#41; en el anciano con las f&#243;rmulas basadas en la creatinina es limitada&#46; El objetivo del estudio es comparar las ecuaciones CKD-EPI&#44; MDRD-IDMS y BIS1 y analizar la correlaci&#243;n y la concordancia en una poblaci&#243;n mayor de 85 a&#241;os&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio transversal retrospectivo y se recogieron datos de 600 pacientes mayores de 85 a&#241;os&#46; Se estim&#243; el FG por las ecuaciones CKD-EPI&#44; MDRD-IDMS y BIS1 a partir de datos de sexo&#44; edad y creatinina&#46; El estudio estad&#237;stico incluy&#243; el test de Wilcoxon&#44; an&#225;lisis de Bland-Altman&#44; rectas de regresi&#243;n de Passing-Bablok&#44; concordancia bruta e &#237;ndice ponderado&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La mediana &#40;intervalo&#41; de edad de los pacientes fue 87 &#40;85-98&#41;&#46; Las medianas del filtrado glomerular estimado por MDRD-IDMS fueron 42&#44;4 &#40;5&#44;2-127&#44;4&#41; mL&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; seg&#250;n CKD-EPI 40&#44;0 &#40;4&#44;5-93&#44;1&#41; mL&#47;min&#47;1&#44;73 m<span class="elsevierStyleSup">2</span> y por BIS1 36&#44;9 &#40;7&#44;6-83&#44;7&#41; mL&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; La comparaci&#243;n mediante test de Wilcoxon de BIS1 con CKD-EPI y MDRD-IDMS fue significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; El an&#225;lisis de regresi&#243;n dio lugar a las siguientes ecuaciones&#58; MDRD-IDMS<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;025<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1&#44;36&#59; BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;688<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CKD-EPI<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>9&#44;074 y BIS1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;666<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>MDRD-IDMS<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>8&#44;401&#46; La concordancia ponderada entre MDRD-IDMS y CKD-EPI fue &#954;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;598&#59; entre MDRD-IDMS y BIS1&#58; &#954;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;812 y entre CKD-EPI y BIS1&#58; &#954;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#44;846&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las estimaciones de FG obtenidas con la ecuaci&#243;n BIS1 no son intercambiables ni con MDRD-IDMS ni con CKD-EPI&#46; La ecuaci&#243;n BIS1 presenta valores m&#225;s bajos que MDRD-IDMS y CKD-EPI&#44; y tiende a clasificar en un estadio mayor de ERC a los pacientes&#44; sobre todo a partir de un FG estimado de 29<span class="elsevierStyleHsp" style=""></span>mL&#47;min&#47;1&#44;73&#160;m<span class="elsevierStyleSup">2</span>&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Pacientes y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Bustos-Guada&#241;o F&#44; Mart&#237;n-Calder&#243;n JL&#44; Criado-&#193;lvarez JJ&#44; Mu&#241;oz-Jara R&#44; Cantalejo-Guti&#233;rrez A&#44; Mena-Moreno MC&#46; Estimaci&#243;n del filtrado glomerular en personas mayores de 85 a&#241;os&#58; comparaci&#243;n de las ecuaciones CKD-EPI&#44; MDRD-IDMS y BIS1&#46; Nefrologia&#46; 2017&#59;37&#58;172&#8211;180&#46;</p>"
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1346
            "Ancho" => 2396
            "Tamanyo" => 119420
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n del estadio de enfermedad renal cr&#243;nica seg&#250;n la f&#243;rmula de c&#225;lculo de FGe&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2513
            "Ancho" => 3306
            "Tamanyo" => 295793
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Rectas de regresi&#243;n de Passing-Bablock de las ecuaciones de filtrado glomerular&#46; Rectas de regresi&#243;n de Passing-Bablok entre las distintas ecuaciones para la estimaci&#243;n del filtrado glomerular&#46; &#40;A&#41; Recta de regresi&#243;n MDRD4-IDMS-CKDEPI&#46; &#40;B&#41; Recta de regresi&#243;n BIS1-CKDEPI&#46; &#40;C&#41; Recta de regresi&#243;n&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 3417
            "Ancho" => 1485
            "Tamanyo" => 340974
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagramas de Bland-Altman BIS1-MDRD4-IDMS&#46; Gr&#225;ficos Bland-Altman en los que se muestra las diferencias en FGe mediante las f&#243;rmulas &#40;A&#41; MDRD4-IDMS y CKDEPI&#59; &#40;B&#41; MDRD4-IDMS y BIS1 y &#40;C&#41; CKDEPI y BIS1&#46; Todos los datos se expresan en mL&#47;min&#47;1&#44;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Results are expressed as median and the interval &#40;minimum and maximum&#41;&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Creatinine &#40;Cr&#41; units&#58; mg&#47;dL and eGFR units&#58; mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Creatinine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BIS1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">CKD-EPI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MDRD-IDMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Females&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">328&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2 &#40;0&#46;5&#8211;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;9 &#40;7&#46;6&#8211;76&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;8 &#40;4&#46;5&#8211;85&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;7 &#40;5&#46;2&#8211;108&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Females Cr<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;76 &#40;0&#46;5&#8211;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;6 &#40;47&#46;1&#8211;76&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;8 &#40;57&#46;6&#8211;85&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;3 &#40;59&#46;2&#8211;108&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Females Cr<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">269&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3 &#40;0&#46;9&#8211;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;1 &#40;7&#46;6&#8211;48&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;3 &#40;4&#46;51&#8211;57&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;4 &#40;5&#46;25&#8211;75&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Males&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">272&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5 &#40;0&#46;6&#8211;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;0 &#40;9&#46;7&#8211;93&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;0 &#40;6&#46;2&#8211;90&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;8 &#40;7&#46;2&#8211;127&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Males Cr<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;9 &#40;0&#46;6&#8211;1&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;2 &#40;48&#46;9&#8211;93&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;0 &#40;59&#46;6&#8211;90&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;1 &#40;63&#46;2&#8211;127&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Males Cr<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;6 &#40;1&#46;1&#8211;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#46;1 &#40;9&#46;7&#8211;50&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;3 &#40;6&#46;2&#8211;60&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;3 &#40;7&#46;2&#8211;63&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423351.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the population&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Non-parametric comparison by Wilcoxon test of eGFR calculated with BIS1 and with MDRD-IDMS and CKD-EPI&#46; Creatinine units&#58; mg&#47;dL&#59; eGFR units&#58; mL&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and the interval &#40;minimum and maximum&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Median&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Interval&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;0&#46;5&#8211;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BIS1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;7&#46;6&#8211;93&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDRD-IDMS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;5&#46;2&#8211;127&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CKD-EPI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#40;4&#46;5&#8211;93&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423353.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Comparison of GFR calculated with BIS1 and with MDRD-IDMS and CKD-EPI&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Numbers in bold are those subjects that did not change the stage&#46;</p><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Numbers in italic are those subjects that changed the stage&#46;</p>"
          "tablatextoimagen" => array:3 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="8" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#40;A&#41; Calculated with MDRD-IDMS and BIS1</th></tr><tr title="table-row"><th class="td" title="table-head  " colspan="8" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MDRD-IDMS</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">BIS1</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">17</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">15</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">72</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">41</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">120</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">173</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">295&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">23</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">111</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">14</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">11</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423352.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="8" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#40;B&#41; Calculated with CKD-EPI and BIS1</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="7" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">CKD-EPI</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">BIS1</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">32</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">64</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">49</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">113&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">106</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">187</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">295&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">132</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">14</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">148&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">11</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">189&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423350.png"
              ]
            ]
            2 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="8" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#40;C&#41; Calculated with CKD-EPI and MDRD-IDMS</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="7" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">CKD-EPI</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">MDRD-IDMS</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">17</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">0</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">79</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">10</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">145</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">16</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3b&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">173</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">23</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">111</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">25</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">189&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423348.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Number of subjects in CKD stages according to calculations with BIS1 vs MDRD-IDMS and CKD-EPI&#44; and MDRD-IDMS vs CKD-EPI&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">SD&#58; standard deviation of the mean differences&#59; 95&#37; CI&#58; 95&#37; confidence interval&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mean differences&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDRD-IDMS-CKD-EPI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDRD-IDMS-BIS1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CKD-EPI-BIS1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1423349.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Bland&#8211;Altman analysis for the 3 equations used to calculate GFR&#46;</p>"
        ]
      ]
      7 => array:5 [
        "identificador" => "eq0005"
        "tipo" => "MULTIMEDIAFORMULA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Formula" => array:5 [
          "Matematica" => "eGFR MDRD-IDMS&#61;175&#215;&#40;Cr&#41;&#8722;1&#46;154&#215;age&#8722;0&#46;203&#215;0&#46;742&#8201;&#8202;&#8202;if female&#41;&#215;1&#46;210&#8201;&#40;if black&#41;eGFR KKD-EPI&#8201;&#40;females and C&#61;0&#46;7&#41;&#61;144&#215;&#40;Cr&#47;0&#46;7&#41;&#8722;0&#46;329&#215;0&#46;993ageeGFR KKD-EPI&#8201;&#40;females and C&#62;0&#46;7&#41;&#61;144&#215;&#40;Cr&#47;0&#46;7&#41;&#8722;1&#46;209&#215;0&#46;993ageeGFR KKD-EPI&#8201;&#40;males and C&#61;0&#46;9&#41;&#61;141&#215;&#40;Cr&#47;0&#46;9&#41;&#8722;0&#46;411&#215;0&#46;993ageeGFR KKD-EPI&#8201;&#40;males and C&#61;0&#46;9&#41;&#61;141&#215;&#40;Cr&#47;0&#46;9&#41;&#8722;1&#46;209&#215;0&#46;993ageeGFR BIS1&#61;3&#46;736&#215;Cr&#8722;0&#46;7&#215;age&#8722;0&#46;95&#215;0&#46;87&#8201;&#40;if female&#41;"
          "Fichero" => "STRIPIN_si1.jpeg"
          "Tamanyo" => 17476
          "Alto" => 157
          "Ancho" => 370
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:27 [
            0 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalencia de la insuficiencia renal cr&#243;nica en Espa&#241;a&#58; resultados del estudio EPIRCE"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Otero"
                            1 => "A&#46;L&#46; de Francisco"
                            2 => "P&#46; Gayoso"
                            3 => "F&#46; Garc&#237;a"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2009.Dic.5732"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "78"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20038967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Documento de consenso para la detecci&#243;n y manejo de la enfermedad renal cr&#243;nica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mart&#237;nez-Castelao"
                            1 => "J&#46;L&#46; G&#243;rriz-Teruel"
                            2 => "J&#46; Bover-Sanju&#225;n"
                            3 => "J&#46; Segura de la Morena"
                            4 => "J&#46; Cebollada"
                            5 => "J&#46; Escalada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2014.Feb.12455"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2014"
                        "volumen" => "34"
                        "paginaInicial" => "243"
                        "paginaFinal" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24658201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simplified equation to predict glomerular filtration rate from serum creatinine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;S&#46; Levey"
                            1 => "T&#46; Greene"
                            2 => "J&#46;W&#46; Kusek"
                            3 => "G&#46;J&#46; Beck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2000"
                        "volumen" => "1"
                        "numero" => "Suppl&#46;"
                        "paginaInicial" => "155A"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674913014887"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new equation to estimate glomerullar filtration rate"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "CKD-EPI &#40;Chronic Kidney Disease Epidemiology Collaboration&#41;"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Levey"
                            1 => "L&#46;A&#46; Stevens"
                            2 => "C&#46;H&#46; Schmid"
                            3 => "Y&#46;L&#46; Zhang"
                            4 => "A&#46;T&#46; Castro 3rd"
                            5 => "H&#46;I&#46; Feldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2009"
                        "volumen" => "150"
                        "paginaInicial" => "604"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19414839"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Kidney Disease Improving Global Outcomes &#40;KDIGO&#41; Work Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Kidney Int Suppl"
                        "fecha" => "2013"
                        "volumen" => "3"
                        "paginaInicial" => "1"
                        "paginaFinal" => "150"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal function in the elderly &#40;&#62;70 years old&#41; measured by means of iohexol clearance&#44; serum creatinine&#44; serum urea and estimated clearance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Fehrman-Ekholm"
                            1 => "L&#46; Skeppholm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00365590310015750"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Urol Nephrol"
                        "fecha" => "2004"
                        "volumen" => "38"
                        "paginaInicial" => "73"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15204431"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimaci&#243;n del filtrado glomerular seg&#250;n MDRD-4 IDMS y CKD-EPI en individuos de edad igual o superior a 60 a&#241;os en Atenci&#243;n Primaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Salvador-Gonz&#225;lez"
                            1 => "L&#46;M&#46; Rodriguez-Latre"
                            2 => "R&#46; G&#252;ell-Mir&#243;"
                            3 => "V&#46; Alvarez-Funes"
                            4 => "H&#46; Sanz-R&#243;denas"
                            5 => "F&#46;J&#46; Tovillas-Mor&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Apr.11929"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "552"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23897188"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of glomerular filtration rate in elderly patients with chronic kidney disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Liu"
                            1 => "J&#46; Chen"
                            2 => "C&#46; Wang"
                            3 => "C&#46; Shi"
                            4 => "C&#46; Cheng"
                            5 => "H&#46; Tang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11255-013-0498-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int Urol Nephrol"
                        "fecha" => "2013"
                        "volumen" => "45"
                        "paginaInicial" => "1475"
                        "paginaFinal" => "1482"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23884726"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0954611114002820"
                          "estado" => "S300"
                          "issn" => "09546111"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparaci&#243;n del uso de las ecuaciones de estimaci&#243;n del filtrado glomerular en personas de 75 a&#241;os o m&#225;s sin enfermedad renal conocida"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; G&#243;mez-Pav&#243;n"
                            1 => "C&#46; G&#225;lvez"
                            2 => "J&#46;J&#46; Bazt&#225;n"
                            3 => "I&#46; Ruip&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2010"
                        "volumen" => "134"
                        "paginaInicial" => "346"
                        "paginaFinal" => "349"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;J&#46; Spruill"
                            1 => "W&#46;E&#46; Wade"
                            2 => "H&#46;H&#46; Cobb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjopharm.2008.07.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Geriatr Pharmacother"
                        "fecha" => "2008"
                        "volumen" => "6"
                        "paginaInicial" => "153"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18775390"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Concordancia entre el aclaramiento de creatinina con las f&#243;rmulas MDRD y CKD-EPI para estimar el filtrado glomerular en personas de 69 a&#241;os o m&#225;s"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Heras"
                            1 => "M&#46;T&#46; Guerrero"
                            2 => "M&#46;J&#46; Fern&#225;ndez-Reyes"
                            3 => "R&#46; S&#225;nchez"
                            4 => "F&#46; Prado"
                            5 => "F&#46; &#193;lvarez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dial Traspl"
                        "fecha" => "2011"
                        "volumen" => "32"
                        "paginaInicial" => "13"
                        "paginaFinal" => "16"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674911018215"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two novel equations to estimate kidney function in persons aged 70 years or older"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;S&#46; Schaeffner"
                            1 => "N&#46; Ebert"
                            2 => "P&#46; Delanaye"
                            3 => "U&#46; Frei"
                            4 => "J&#46; Gardeke"
                            5 => "O&#46; Jacob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-157-7-201210020-00003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2012"
                        "volumen" => "157"
                        "paginaInicial" => "471"
                        "paginaFinal" => "481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23027318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "External validation of the Berlin equations for estimation of GFR in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Alshaer"
                            1 => "H&#46; Killbride"
                            2 => "P&#46; Stevens"
                            3 => "G&#46; Eaglestone"
                            4 => "S&#46; Knight"
                            5 => "J&#46;L&#46; Carter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2014.01.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "862"
                        "paginaFinal" => "865"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24529537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "External validation of the BIS &#40;Berlin Initiative Study&#41;-1 GFR estimating equation in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Vidal-Petiot"
                            1 => "J&#46;P&#46; Haymann"
                            2 => "E&#46; Letavernier"
                            3 => "F&#46; Serrano"
                            4 => "C&#46; Clerici"
                            5 => "J&#46;J&#46; Boffa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "855"
                        "paginaFinal" => "866"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new biometrical procedure for testing the equality of measurements from two different analytical methods&#46; Application of lineal regression procedures for method comparison studies in clinical chemistry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; Passing"
                            1 => "W&#46; Bablok"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Chem Clin Biochem"
                        "fecha" => "1983"
                        "volumen" => "21"
                        "paginaInicial" => "709"
                        "paginaFinal" => "720"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6655447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical method for assessing agreement between two methods of clinical measurement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Bland"
                            1 => "D&#46;G&#46; Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2468-1253(16)30077-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1986"
                        "volumen" => "1"
                        "paginaInicial" => "307"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28404201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diferencias entre filtrado glomerular disminuido e insuficiencia renal&#58; riesgos de asociar estos 2 conceptos en el anciano sano"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; &#193;lvarez-Gregori"
                            1 => "J&#46;F&#46; Mac&#237;as-N&#250;&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Geriatr Gerontol"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "184"
                        "paginaFinal" => "187"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimating glomerular filtration rate in older people"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Garasto"
                            1 => "S&#46; Fusco"
                            2 => "F&#46; Corica"
                            3 => "M&#46; Rosignoulo"
                            4 => "A&#46; Marino"
                            5 => "A&#46; Montesanto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2014/916542"
                      "Revista" => array:5 [
                        "tituloSerie" => "BioMed Res Int"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "916542"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24772439"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;accessed 18&#46;09&#46;15&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Lopes"
                            1 => "L&#46; Ara&#250;jo"
                            2 => "M&#46; Passos"
                            3 => "S&#46; Nishida"
                            4 => "G&#46; Kirstajn"
                            5 => "Cendoroglo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-14-265"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24295505"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1186/1471-2369-14-265"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;www&#46;biomedcentral&#46;com&#47;1747-2369&#47;14&#47;265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of creatinine equations compared in older patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Koppe"
                            1 => "A&#46; Klich"
                            2 => "L&#46; Dubourg"
                            3 => "R&#46; Ecochard"
                            4 => "A&#46; Hadj-Aissa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5301/jn.5000297"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nephrol"
                        "fecha" => "2013"
                        "volumen" => "26"
                        "paginaInicial" => "716"
                        "paginaFinal" => "723"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23843047"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;Es v&#225;lido el valor cr&#237;tico de filtrado glomerular estimado de 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min para etiquetar de insuficiencia renal a personas mayores de 70 a&#241;os&#63; Consecuencias de su aplicaci&#243;n indiscriminada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; &#193;lvarez-Gregori"
                            1 => "C&#46;G&#46; Musso"
                            2 => "N&#46;R&#46; Robles"
                            3 => "J&#46; Herrera"
                            4 => "J&#46;F&#46; Mac&#237;as-N&#250;&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "NefroPlus"
                        "fecha" => "2011"
                        "volumen" => "4"
                        "paginaInicial" => "7"
                        "paginaFinal" => "17"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparaci&#243;n de la ecuaci&#243;n CKD-EPI respecto a MDRD-IDMS en la derivaci&#243;n de pacientes a Nefrolog&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Gui&#241;on-Mu&#241;oz"
                            1 => "C&#46; Gutierrez-Forn&#233;s"
                            2 => "A&#46; Molina-Borr&#225;s"
                            3 => "A&#46; Martinez-Bea"
                            4 => "N&#46; Serrat-Or&#250;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Lab Clin"
                        "fecha" => "2014"
                        "volumen" => "7"
                        "paginaInicial" => "60"
                        "paginaFinal" => "67"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy of the MDRD &#40;Modification of Diet in Renal Disease&#41; Study and CKD-EPI &#40;CKD Epidemiology Collaboration&#41; equations for estimation of GFR in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;S&#46; Kilbride"
                            1 => "P&#46; Stevens"
                            2 => "G&#46; Eaglestone"
                            3 => "S&#46; Knight"
                            4 => "J&#46;L&#46; Carter"
                            5 => "M&#46;P&#46; Delaney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.ajkd.2012.06.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2013"
                        "volumen" => "61"
                        "paginaInicial" => "57"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22889713"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimaci&#243;n del filtrado glomerular seg&#250;n MDRD-4 IDMS y CKD-EPI en individuos de edad igual o superior a 60 a&#241;os en Atenci&#243;n Primaria"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "MACAP RENAL"
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Salvador-Gonz&#225;lez"
                            1 => "L&#46;M&#46; Rodriguez-Latre"
                            2 => "R&#46; G&#252;ell-Mir&#243;"
                            3 => "V&#46; &#193;lvarez-Funes"
                            4 => "H&#46; Sanz-R&#243;denas"
                            5 => "F&#46;J&#46; Tovillas-Mor&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2013.Apr.11929"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrolog&#237;a"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "552"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23897188"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;accessed 18&#46;09&#46;15&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of Cockroft-Gault&#44; MDRD&#44; and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Willems"
                            1 => "T&#46; Vlasveld"
                            2 => "W&#46;P&#46; den Elzen"
                            3 => "R&#46;G&#46; Westendorp"
                            4 => "T&#46;J&#46; Rabelink"
                            5 => "A&#46;J&#46; de Craen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2318-13-113"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Geriatr"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24160772"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1186/1471-2318-13-113"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;www&#46;biomedcentral&#46;com&#47;1471-2318&#47;13&#47;113"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Capacidad diagn&#243;stica de las ecuaciones Chronic Kidney Disease Epidemiology Collaboration y Modification of Diet in Renal Disease-4 en la estimaci&#243;n del filtrado glomerular en pacientes pluripatol&#243;gicos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Cabrerizo-Garc&#237;a"
                            1 => "J&#46; Diez-Manglano"
                            2 => "E&#46; Garc&#237;a-Arilla"
                            3 => "P&#46; Revillo-Pinilla"
                            4 => "J&#46; Ram&#243;n-Puertas"
                            5 => "M&#46; Sebasti&#225;n-Royo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2015"
                        "volumen" => "144"
                        "paginaInicial" => "14"
                        "paginaFinal" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimating glomerular filtration rate&#58; comparison of the CKD-EPI and MDRD equations in a large UK cohort with particular emphasis on the effect of age"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;L&#46; Carter"
                            1 => "P&#46;E&#46; Stevens"
                            2 => "J&#46;E&#46; Irving"
                            3 => "E&#46;J&#46; Lamb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/qjmed/hcr077"
                      "Revista" => array:6 [
                        "tituloSerie" => "QJM"
                        "fecha" => "2011"
                        "volumen" => "104"
                        "paginaInicial" => "839"
                        "paginaFinal" => "847"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21652537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003700000002/v1_201705250045/S2013251417300834/v1_201705250045/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42660"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003700000002/v1_201705250045/S2013251417300834/v1_201705250045/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300834?idApp=UINPBA000064"
]