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the anti-DNA&#44; positive &#40;33<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41;&#59; and the ENA&#44; SSA&#44; SSB&#44; U1RNP&#44; Sm and SCL70&#44; negative&#46; The lupus anticoagulant &#40;2&#46;3&#41; and the IgG anticardiolipin antibodies &#40;253<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41; were positive&#44; with decreased C3 levels &#40;70<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; The kidney biopsy showed a type <span class="elsevierStyleSmallCaps">III</span> lupus nephritis&#46; There were only 3 glomeruli &#40;2 with an increased mesangial matrix and one with focal and segmental sclerosis&#47;hyalinosis&#41; with no &#8220;wire loop&#8221; lesions or glomerular crescent formations&#46; Immunofluorescence showed deposits in the mesangium and the glomerular basement membrane of high intensity for IgG&#44; C3 and C1Q&#44; and mild&#47;moderate intensity for IgA&#44; IgM and C4&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient had cardiac murmur in the auscultation and the fever persisted&#44; so an echocardiogram was performed that showed a bicuspid aortic valve with a vegetation s on the free edge of its 2 leaflets causing a severe insufficiency&#46; Although it was unlikely that this lesion was caused by an infection&#44; owing to the negative result on the blood cultures&#44; a cardiac MRI with contrast dye was performed to clarify the diagnosis&#46; In this examination&#44; in addition to the vegetation there was subepicardial enhancement inferolateral&#44; suggestive of a vasculitic process &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with no evidence of abscess&#44; pericardial effusion or other complications&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">With a diagnosis of Libman-Sacks endocarditis &#40;LSE&#41;&#44; anticoagulant therapy was started&#44; combined with steroids &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41; and mycophenolate &#40;MMF&#41; up to a dose of 1<span class="elsevierStyleHsp" style=""></span>g&#47;12<span class="elsevierStyleHsp" style=""></span>h&#46; After one&#44; she has normal kidney function&#44; the aortic insufficiency has improved to a more moderate gradient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although the use of steroids in the treatment of systemic lupus erythematosus &#40;SLE&#41; has caused a significant reduction in the incidence of LSE&#44; its current frequency could be up to 10&#8211;35&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; its clinical manifestations tend to be mild&#44; and so it often happens unnoticed&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> LSE is usually associated with a long duration of the disease and with the existence of anticardiolipin antibodies &#40;aCL&#41; and antiphospholipid syndrome &#40;APS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;3</span></a> The &#8220;two-hit hypothesis&#8221;&#44; described by Bordin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> suggests that the pro-thrombotic state generated by aCL &#40;first event&#41; would promote &#40;after a second event such as heart surgery&#44; pregnancy&#44; etc&#46;&#41; the formation of a blood clot on a previously inflamed valvular endothelium&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#8211;5</span></a> In the present case&#44; at least from a renal point of view&#44; the disease was not of long duration&#44; but&#44; based on the two-hit hypothesis&#44; one might speculate that&#44; the presence of an aCL-positive during lupus flare-up&#44; plus the damage caused by the haematoma and subsequent embolization&#44; could trigger endocarditis on a valve that is&#44; susceptible because a bicuspid morphology&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This case also illustrates the difficulty of a differential diagnosis vs other valvular malformations or infective endocarditis itself&#44; which may be colonizing on a previous LSE lesion&#46; Although LSE is usually located on the mitral valve&#44; it can also occur on the aortic &#40;as in our case&#41;&#44; the tricuspid &#40;less than 10&#37; of cases&#41; and the pulmonary valve&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;3</span></a> Because there was no characteristic location or echocardiographic image&#44; the MRI was very useful in clearing up the diagnosis&#44; a finding also documented by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Regarding treatment&#44; surgery is reserved for cases of severe valvular dysfunction or with large mobile masses with high risk of embolization&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Although steroid treatment may reduce lesions&#44; it is generally not sufficient for eradicating the embolic risk&#44; so patients should be anticoagulated&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In our case&#44; and also given the presence of APS and lupus nephritis&#44; treatment with MMF was proposed&#44; with a good renal response and a striking heart response as well&#44; and with a significant improvement of the lesions&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; LSE should be included in the differential diagnosis of a patient with SLE and fever&#44; especially if the test is positive for anticardiolipin antibodies and there is a previous triggering factor&#46; In the absence of specific markers&#44; MRI is an important tool for elucidate the diagnosis&#46; Although valvular dysfunction is rare&#44; when it occurs&#44; treatment with steroids and MMF may reduce the lesions and postpone the need for valve replacement&#46; However&#44; given the embolic risk involved&#44; maintaining anticoagulation with close clinical and imaging observation is essential&#46;</p></span>"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Libman-Sacks endocarditis in systemic lupus erythematosus&#58; prevalence&#44; associations&#44; and evolution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Moyssakis"
                            1 => "M&#46;G&#46; Tektonidou"
                            2 => "V&#46;A&#46; Vassilliou"
                            3 => "M&#46; Samarkos"
                            4 => "V&#46; Votteas"
                            5 => "H&#46;M&#46; Moutsopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjmed.2007.01.024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2007"
                        "volumen" => "120"
                        "paginaInicial" => "636"
                        "paginaFinal" => "642"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17602939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Libman-Sacks endocarditis as the first manifestation of systemic lupus erythematosus in an adolescent&#44; with a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Sharma"
                            1 => "Z&#46; Lasic"
                            2 => "A&#46; Bornstein"
                            3 => "R&#46; Cooper"
                            4 => "J&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/S1047951112001023"
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                        "tituloSerie" => "Cardiol Young"
                        "fecha" => "2013"
                        "volumen" => "23"
                        "paginaInicial" => "1"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22805592"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk for heart valve disease associated with antiphospholipid antibodies in patients with systemic lupus erythematosus&#58; meta-analysis of echocardiographic studies"
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                        0 => array:2 [
                          "etal" => true
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                            1 => "V&#46; Regnault"
                            2 => "C&#46; Selton-Suty"
                            3 => "V&#46; Eschw&#233;ge"
                            4 => "J&#46;F&#46; Bruntz"
                            5 => "E&#46; Bode-Dotto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.111.028522"
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                        "tituloSerie" => "Circulation"
                        "fecha" => "2011"
                        "volumen" => "124"
                        "paginaInicial" => "215"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21690492"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The two hit hypothesis in the antiphospholipid syndrome&#58; acute ischaemic heart involvement after valvular replacement despite anticoagulation in a patient with secondary APS"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "P&#46;L&#46; Meroni"
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                        "link" => array:1 [
                          0 => array:2 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-thromboembolic risk in systemic lupus erythematosus associated with antiphospholipid syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "M&#46; Bocskai"
                            2 => "S&#46; Burcs&#225;r"
                            3 => "O&#46; D&#225;nyi"
                            4 => "Z&#46; Fekete"
                            5 => "L&#46; Kov&#225;cs"
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                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1177/0961203314531839"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24729279"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severe mitral stenosis as the first manifestation of systemic lupus erythematosus in a 20-year-old woman&#58; the value of magnetic resonance imaging in the diagnosis of Libman-Sacks endocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Gouya"
                            1 => "L&#46; Cabanes"
                            2 => "L&#46; Mouthon"
                            3 => "A&#46; Pavie"
                            4 => "P&#46; Legmann"
                            5 => "O&#46; Vignaux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10554-014-0418-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cardiovasc Imaging"
                        "fecha" => "2014"
                        "volumen" => "30"
                        "paginaInicial" => "959"
                        "paginaFinal" => "960"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24715438"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
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              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unusual case of nonbacterial thrombotic endocarditis attributable to primary antiphospholipid syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "L&#46;A&#46; Lanza"
                            3 => "S&#46;J&#46; Lester"
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                    ]
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                        "volumen" => "122"
                        "paginaInicial" => "e459"
                        "paginaFinal" => "e460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20855665"
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                  ]
                ]
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                      "titulo" => "Left ventricular vegetations&#58; a rare manifestation of Libman-Sacks endocarditis"
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                          "etal" => false
                          "autores" => array:4 [
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                        ]
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                        "fecha" => "2013"
                        "volumen" => "145"
                        "paginaInicial" => "e26"
                        "paginaFinal" => "e28"
                        "link" => array:1 [
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Letter to the Editor
Libman-Sacks’ endocarditis: A frequently unnoticed complication
Endocarditis de Libman-Sacks: una manifestación frecuentemente inadvertida
Nerea Gómez-Larrambea, Lourdes González-Tabarésa, Beatriz Millána, Carmen Cobeloa, Victor Armestob, Montserrat Pousac, Secundino Cigarránc, Jesus Calviñoa,
Corresponding author
jesus.calvino.varela@sergas.es

Corresponding author.
a Servicio de Nefrología Hospital Universitario Lucus Augusti, Lugo, Spain
b Servicio de Radiología Hospital Universitario Lucus Augusti, Lugo, Spain
c Servicio de Nefrología Hospital da Costa Burela, Lugo, Spain
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the anti-DNA&#44; positive &#40;33<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41;&#59; and the ENA&#44; SSA&#44; SSB&#44; U1RNP&#44; Sm and SCL70&#44; negative&#46; The lupus anticoagulant &#40;2&#46;3&#41; and the IgG anticardiolipin antibodies &#40;253<span class="elsevierStyleHsp" style=""></span>U&#47;ml&#41; were positive&#44; with decreased C3 levels &#40;70<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; The kidney biopsy showed a type <span class="elsevierStyleSmallCaps">III</span> lupus nephritis&#46; There were only 3 glomeruli &#40;2 with an increased mesangial matrix and one with focal and segmental sclerosis&#47;hyalinosis&#41; with no &#8220;wire loop&#8221; lesions or glomerular crescent formations&#46; Immunofluorescence showed deposits in the mesangium and the glomerular basement membrane of high intensity for IgG&#44; C3 and C1Q&#44; and mild&#47;moderate intensity for IgA&#44; IgM and C4&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient had cardiac murmur in the auscultation and the fever persisted&#44; so an echocardiogram was performed that showed a bicuspid aortic valve with a vegetation s on the free edge of its 2 leaflets causing a severe insufficiency&#46; Although it was unlikely that this lesion was caused by an infection&#44; owing to the negative result on the blood cultures&#44; a cardiac MRI with contrast dye was performed to clarify the diagnosis&#46; In this examination&#44; in addition to the vegetation there was subepicardial enhancement inferolateral&#44; suggestive of a vasculitic process &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; with no evidence of abscess&#44; pericardial effusion or other complications&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">With a diagnosis of Libman-Sacks endocarditis &#40;LSE&#41;&#44; anticoagulant therapy was started&#44; combined with steroids &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41; and mycophenolate &#40;MMF&#41; up to a dose of 1<span class="elsevierStyleHsp" style=""></span>g&#47;12<span class="elsevierStyleHsp" style=""></span>h&#46; After one&#44; she has normal kidney function&#44; the aortic insufficiency has improved to a more moderate gradient&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although the use of steroids in the treatment of systemic lupus erythematosus &#40;SLE&#41; has caused a significant reduction in the incidence of LSE&#44; its current frequency could be up to 10&#8211;35&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a> However&#44; its clinical manifestations tend to be mild&#44; and so it often happens unnoticed&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> LSE is usually associated with a long duration of the disease and with the existence of anticardiolipin antibodies &#40;aCL&#41; and antiphospholipid syndrome &#40;APS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;3</span></a> The &#8220;two-hit hypothesis&#8221;&#44; described by Bordin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> suggests that the pro-thrombotic state generated by aCL &#40;first event&#41; would promote &#40;after a second event such as heart surgery&#44; pregnancy&#44; etc&#46;&#41; the formation of a blood clot on a previously inflamed valvular endothelium&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#8211;5</span></a> In the present case&#44; at least from a renal point of view&#44; the disease was not of long duration&#44; but&#44; based on the two-hit hypothesis&#44; one might speculate that&#44; the presence of an aCL-positive during lupus flare-up&#44; plus the damage caused by the haematoma and subsequent embolization&#44; could trigger endocarditis on a valve that is&#44; susceptible because a bicuspid morphology&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This case also illustrates the difficulty of a differential diagnosis vs other valvular malformations or infective endocarditis itself&#44; which may be colonizing on a previous LSE lesion&#46; Although LSE is usually located on the mitral valve&#44; it can also occur on the aortic &#40;as in our case&#41;&#44; the tricuspid &#40;less than 10&#37; of cases&#41; and the pulmonary valve&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;3</span></a> Because there was no characteristic location or echocardiographic image&#44; the MRI was very useful in clearing up the diagnosis&#44; a finding also documented by other authors&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Regarding treatment&#44; surgery is reserved for cases of severe valvular dysfunction or with large mobile masses with high risk of embolization&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Although steroid treatment may reduce lesions&#44; it is generally not sufficient for eradicating the embolic risk&#44; so patients should be anticoagulated&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In our case&#44; and also given the presence of APS and lupus nephritis&#44; treatment with MMF was proposed&#44; with a good renal response and a striking heart response as well&#44; and with a significant improvement of the lesions&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; LSE should be included in the differential diagnosis of a patient with SLE and fever&#44; especially if the test is positive for anticardiolipin antibodies and there is a previous triggering factor&#46; In the absence of specific markers&#44; MRI is an important tool for elucidate the diagnosis&#46; Although valvular dysfunction is rare&#44; when it occurs&#44; treatment with steroids and MMF may reduce the lesions and postpone the need for valve replacement&#46; However&#44; given the embolic risk involved&#44; maintaining anticoagulation with close clinical and imaging observation is essential&#46;</p></span>"
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ISSN: 20132514
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