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Rectas de regresión de Passing-Bablok entre las distintas ecuaciones para la estimación del filtrado glomerular. (A) Recta de regresión MDRD4-IDMS-CKDEPI. (B) Recta de regresión BIS1-CKDEPI. 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In 2002, data from the Spanish Registry of Renal Patients (SRRP – <span class="elsevierStyleItalic">Registro Español de Enfermos Renales</span>), the Spanish Society of Nephrology (SSN – <span class="elsevierStyleItalic">Sociedad Española de Nefrología</span>) and the Spanish National Transplant Organisation (NTO – <span class="elsevierStyleItalic">Organización Nacional de Trasplantes</span>) showed an incidence of CKD stage 5 of 132 patients per million population (PMP), 94.4% of whom started renal replacement therapy (RRT), with haemodialysis (HD) as the first RRT; 4.6% started RRT with peritoneal dialysis (PD); and only 1% received an early renal transplantation (RT). The prevalence of CKD stage 5 in that year was 895 patients PMP.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Incidence decreased to 120.4 patients PMP in 2012, but prevalence increased steadily, mainly due to the accumulation of patients who maintained a functioning RT.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a> Data of year 2014 from the same registry, presented at the 45th SSN Conference in Valencia in October 2015, which included for the first time 100% of the population, showed that incidence was 133.6 patients PMP and the prevalence was 1179.3 patients PMP,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> for a Spanish population that at that time was 46,771,341 inhabitants.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In Catalonia the incidence of stage 5 CKD in 2002 was 146.8 PMP and the prevalence, 1017.8.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> Data from the Catalan Registry of Renal Patients (CRRP – <span class="elsevierStyleItalic">Registre de Malalts Renals de Catalunya</span>) for 2013 showed an incidence of 145.0 PMP and a prevalence of 1262.2.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In Spain the annual cost of RRT for CKD stage 5 is more than 800 million euros. Although there are several estimates, this cost may represent up to 2.5% of the government's total annual health budget.<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">6–9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Health care providers dealing with this disease, as well as patients themselves, face complex decisions such as, in most cases, making a decision of how the level of functional autonomy conditions the election the modality of RRT. Regarding RT, a risk–benefit analysis for patients has to be evaluated. And, of course, they must help to decide whether a patient should elect a conservative therapy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">All these decisions should be made by the patients themselves, with the help of health professionals, based on the best available evidence, and obviously, with the relevant family support, so that CKD patients are made aware of the risks and benefits of the different options used to treat their disease.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In the 1970s, Wennberg et al.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> studied the variations in health care service delivery. Since then, numerous studies have shown that place of residence may condition the number of hospitalisations, diagnostic tests or treatments, regardless of age, sex and the usual adjustment factors. Variations in health care delivery are matter of concern, because they indicate that some citizens receive less attention than they need, while others receive more and others receive care that they do not need,<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> with a subsequent impact on both outcome indicators and health budgets that are limited. In Spain, as part of the “Atlas of Variations in Health Care Delivery in the National Health Service” project,<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> and the one recently launched in Catalonia as part of this work,<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a> numerous studies have been conducted to analyse these variations for different diseases and procedures, although none have been dedicated to RRT. The study of RRT variations is of significant interest for patients and health care providers in terms of assessing whether the indications regarding the different RRT options—HD, PD or RT—are different according to geographic variability.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In a study of 31,778 patients at 56 sites in 13 regions of Canada, Sood et al.,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> adjusting the model by patient, site and region, it was found a variability in PD indication as the first RRT, with substantial differences in low indication (odds ratio 1.51; CI 95%: 1.33–1.73) versus high indication rates (odds ratio 0.69; CI 95%: 0.60–0.79), that were attributable to geographic region.</p><p id="par0040" class="elsevierStylePara elsevierViewall">A few months later, these authors<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> reported the findings on the study, extended to 33,263 patients and carried out between January 2001 and December 2010 at 63 sites in 14 different regions, also in Canada. Adjusting the model to type of patient and the dialysis centre, they found a variability in the indication of PD for RRT that was attributable in 96.9% of cases to the patient—case mix index—and in 3.1% of cases to the dialysis centre, with no variability in this study in relation to the region where the patients were included.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Couchaud et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> published data from the REIN registry. It was analysed the variability in PD indication in 10,815 incident cases from 59 districts in France and they compare, by using logistic regression models, factors such as age, gender, presence of diabetes, congestive heart failure, behavioural disorders, mobility and employment. PD was indicated in 14% of the incident cases, but with a large variability, from 0% to 45%, depending on the districts. The authors concluded that PD may be indicated in a wide array of different clinical conditions and that patients’ preferences play an important role in the choice of RRT method and therefore in this variability.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The aim of our study was to assess whether any variability in RRT indication might be due to inequity to the access or to other factors in different areas of health care in Catalonia.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0055" class="elsevierStylePara elsevierViewall">Ecological study of variability in RRT by areas of health care. An ecological study is a type of epidemiological study, in which the unit of analysis is a set of individuals from a community that is well-defined geographically. Ecological studies allows to analyse the frequency of a disease.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The study's main source of data was the Catalan Transplant Organisation's (CTO) CRRP. From January 1, 2002 to December 31, 2012, incident cases on HD and PD per year were selected according to age (<45, 45–64 and ≥65 years) and gender. Given the low incidence of RT as the first RRT it was more appropriate to work with prevalent cases in the years 2005, 2009 and 2012. The denominator to calculate activity rate (the number of inhabitants of each area) was obtained from the Central Registry of Insured Persons of the Catalan Health Service (CatSalut), the public insurance.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a> We also obtained from this source the structure by age group and gender group to calculate indirect standardisation.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The unit of analysis—i.e. the geographic areas—are the 45 areas of Heath Care Management from the 7 Health Care Regions of Catalonia. The areas of health care management are clusters of basic health care areas, which define regions formed by one or more hospitals and closely related basic health care areas. It is an intermediate level of organisation where primary and specialised care activities are coordinated.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The outcome measures used in this study were the crude incidence rates of HD and PD by area (per 100,000 inhabitants). The standardised ratio of HD and PD incidence compare the interventions performed by the residents in an (observed) area with those that would have been performed (expected) if each of their age/gender groups had an utilisation to equal the whole set. Last, we analysed the prevalence of RT in 2005, 2009 and 2012 by area and by group of age and gender.</p><p id="par0075" class="elsevierStylePara elsevierViewall">First the crude and standardised HD and PD rates were calculated by area and by groups of age and gender. Next, the usual statistics parameters of variability were estimated in an analysis of small areas<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a>: the rate of variation between the 75th and 25th percentiles (RV 25–75), the systematic coefficient of variation (SCV) and the empirical Bayes (EB) approach. The SCV and EB are statistics parameters of variation that take into account the part of the variation that is expected for the type of phenomenon and population analysed. Both identify a source of variation between areas (which is expected to be systematic) and another source of variation within the area (which is expected to be at random). Although they usually use similar values, the EB is a better estimator than the SCV when the events in the areas are uncommon, as the EB corrects the effect of over-dispersion or extra-variation that tends to produce estimates of extreme systematic variation. For both statistics, the higher the value, the greater the systematic variation. By using a procedure with no systematic variation as a reference, such as a hip fracture, it has traditionally been agreed that values up to 0.05 involve no systematic variation; up to 0.10–20, moderate variation; and from 0.20, high variation. However, it is essential to put the value in a given context for each study.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Then, the standardised HD and PD ratios were constructed, which were described by using dot charts—in which each area is represented by a dot—and one map for each health area. All the analyses were performed using STATA, v13.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Maps of RRT variations: haemodialysis</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Activity</span><p id="par0085" class="elsevierStylePara elsevierViewall">Between January 1, 2002 and December 31, 2012, 9238 patients started RRT using HD. Of these, 64% were men and 62% were >65 years. During this period, the cumulative incidence rates of HD decreased from 61 treatments per 100,000 inhabitants in the period 2002–2005 to 50 treatments per 100,000 inhabitants in the period 2010–2012 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The decrease in HD indication as the first RRT is related to the increase of PD and to the early RT. From 2010 to 2012, HD represented 80% of the indication in incident cases, while from 2002 to 2005, it was 90%.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Magnitude of variation</span><p id="par0095" class="elsevierStylePara elsevierViewall">The ratio of variation (RV<span class="elsevierStyleInf">25–75</span>) of the rate of HD relative to that of PD and RT was 1.3 times higher in women and 1.2 times higher in men respectively. By age group, the RC<span class="elsevierStyleInf">25–75</span> was similar among those >45 and higher in <45. The statistic value that quantifies the non-random variation by area showed, as a whole and over time, a value associated with virtually no variation (EB<span class="elsevierStyleHsp" style=""></span>≈<span class="elsevierStyleHsp" style=""></span>0) <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). When studying the standardised ratio by age group, there was a pattern of zero variation, in which no area was significantly different from the mean in Catalonia.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Map of RRT variations: peritoneal dialysis</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Activity</span><p id="par0100" class="elsevierStylePara elsevierViewall">Between January 1, 2002 and December 31, 2012, 1076 patients started RRT using PD. 68% were men and 42% were between the ages of 45 and 65. In the period studied, the cumulative incidence rates of PD increased from 5.1 new patients per 100,000 inhabitants in the period 2002–2005 to 8.2 per 100,000 inhabitants in the period 2010–2012. In this period, PD represented 13% of incident cases of RRTs, whereas in the period 2002–2005, it was 8% of incident cases of RRTs. <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a> shows the cumulative incidence rates by age and gender g.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Magnitude of variation</span><p id="par0105" class="elsevierStylePara elsevierViewall">The difference between the areas with a highest and lowest standardised incidence rate of PD was 8 times in women and 3 times in men. By age group, the ratio was 8 times between those <45 and those >65. The statistic that quantifies the non-random variation by area showed, as a whole and over time, a value associated with a moderate variation (EB<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.08) (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a> shows the geographic distribution of the ratios of standardised incidence of PD by age group. The maps show a pattern of zero variation among patients <45 years, none of the areas was significantly different from the expected values in relation to the standardised rate in Catalonia. However for patients >45 years, the areas of Segrià, Garrigues, Pla d’Urgell, Segarra, Noguera and Garrotxa, in the province of Girona, have a number of observed cases 20% greater than the expected values calculated from the standardised average rate in Catalonia.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The effect of existence of a dialysis centre or nephrology care unit in the area was also analysed. The results showed that there was no significant association with the number of PD cases in these areas.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Atlas of RRT variations: kidney transplant</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Activity</span><p id="par0120" class="elsevierStylePara elsevierViewall">Between January 1, 2002 and December 31, 2012, 4750 patients received RT; a 76% had been treated with HD previously; 62% were men and 49% were 45–65 years old. The percent of patients that were on PD as prior to RT doubled, from 6.2% in 2002 to 14.4% in 2012. Likewise, the percentage of patients who received an early RT rose from 6% in 2002 to 13.8% in 2012. The percentage of living donors RT also increased from 2.1% in 2002 to 16.7% in 2012.</p><p id="par0125" class="elsevierStylePara elsevierViewall">The percentage of patients receiving a RT compared with the total number of patients on RRT increased from 43% in 2005 to 54% in 2012.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Magnitude of variation</span><p id="par0130" class="elsevierStylePara elsevierViewall">The difference between the areas with a highest and lowest standardised prevalence rate of RT was 40% (RC<span class="elsevierStyleInf">25–75</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.4). The statistic parameter that quantifies the non-random variation by area showed, over time, a null value associated with a significant variation (EB<span class="elsevierStyleHsp" style=""></span>≈<span class="elsevierStyleHsp" style=""></span>0).</p><p id="par0135" class="elsevierStylePara elsevierViewall">Given the low incidence of RT as the first RRT, it was considered more appropriate to work with the prevalent cases in 3 years. Therefore, 3 cut-offs were used in the study to explain the percentage of RT in relation to the total RRT prevalent in 2005, 2009 and 2012. In the maps the pattern was homogeneous, with minimal differences between regions (<a class="elsevierStyleCrossRef" href="#fig0030">Fig. 6</a>).</p><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">Despite the increase in the incidence of PD as the first choice for RRT, there is an relatively low use of PD as compared with the most recent data from the Spanish registry<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> and from the European Renal Association-European Dialysis & Transplant Association (ERA-EDTA).<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">19</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">The indication of PD and early RT as the first RRT is more frequent in patients <45 years of age. In this age group, the incidence of PD is three times greater than in >65 years and it is 50% higher than in patients 45–65 years of age.</p><p id="par0150" class="elsevierStylePara elsevierViewall">No significant region-related variability was observed in incident cases receiving HD as the first RRT option; the same can be said about RT. All this leads us to believe that in our entire community there is a balanced equity to access RRT.</p><p id="par0155" class="elsevierStylePara elsevierViewall">However, it was observed region-related variability in the indication of PD. The areas of Lérida and Garrotxa (in Girona) show a higher incidence of PD as compared with the median incidence in Catalonia.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Similar results have been observed in other countries where the use of HD and PD may show region-related variations, which seem to be related to the development of specific programmes by Nephrology Services.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> We believe that similarly to what has been observed in other countries the variability in the use of the different modalities of RRT, specific programmes generated by the nephrologist are making a difference. Other factors such as associated comorbidities or patients’ age, or even the organisational model of care or the ownership of the centres do not explain the region-related variations. All centres that offer HD are either publicly or private. The centres that perform RT are public. The centres that offer PD are public, but agreements are made with suppliers that provide the materials needed to perform PD, either continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD).</p><p id="par0165" class="elsevierStylePara elsevierViewall">To reduce the region-related variability in PD, it would be advisable to increase its indication in the rest of the areas so the PD reach levels similar to Lérida and Garrotxa in Girona.</p><p id="par0170" class="elsevierStylePara elsevierViewall">To reach such objective, several aspects should be improved. First, it is necessary to develop or refine existing support tools that help to make shared decision about the most suitable choice of RRT. This decision has to be shared by the various actors—doctors, nurses, health officials—and the patients themselves and their families. It is important to consider the patients’ preferences, and to maintain and improve their quality of life as much as possible. The patients must have access to objective, regulated, understandable and detailed information on the different methods of RRT; this is essential when deciding on the RRT method. An informed and reasoned choice made by patients must be a fundamental element in the decision.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Second, further training of resident and fellows doctors should be enhanced, as well as maintaining and improving the ongoing training of health professionals working with CKD and PD, either in a centre itself or at centres with a PD programme. Third, the adoption of PD as the first RRT method should be promoted, with incentive-based reimbursement in contracts with different suppliers.</p><p id="par0180" class="elsevierStylePara elsevierViewall">Finally, it would be desirable to analyse other potential types of region-related variability, such as the time needed to access the RT waiting list, or to analyse whether there are differences in access to RT depending on areas of residence. In Catalonia, the CTO is working in a comprehensive way to organise the proper management, uniformity and dissemination of all sources of information. This task will help to obtain data to evaluate and propose different actions and road maps.</p><p id="par0185" class="elsevierStylePara elsevierViewall">In addition, the rates of patients >80 years in RRT have increased significantly in recent years.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2,3,19</span></a> The current volume of cases is still insufficient to conduct a variability study in this population which will undoubtedly be of interest in future studies due to the fragility and complexity of this subgroup of patients.</p><p id="par0190" class="elsevierStylePara elsevierViewall">Lastly, the results of this study may be affected by some limitations related to the quality of the data sources and by the usual limitations of the ecological design, limitations which affect the causality of the relationships observed and their transference to the individual level.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">In conclusion, there has been a notable increase in PD and early RT indications, but the rates for PD are still below the average for Spain and Europe. The variability is similar to that observed in other countries; it is worth to mention the regional variations in PD in Catalonia.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicts of interest</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare that there are no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres842781" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec837990" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres842782" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec837991" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0020" "titulo" => "Maps of RRT variations: haemodialysis" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Activity" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Magnitude of variation" ] ] ] 1 => array:3 [ "identificador" => "sec0035" "titulo" => "Map of RRT variations: peritoneal dialysis" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Activity" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Magnitude of variation" ] ] ] 2 => array:3 [ "identificador" => "sec0050" "titulo" => "Atlas of RRT variations: kidney transplant" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Activity" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Magnitude of variation" ] ] ] ] ] 7 => array:2 [ "identificador" => "sec0065" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflicts of interest" ] 9 => array:2 [ "identificador" => "xack283124" "titulo" => "Acknowledgements" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-02-04" "fechaAceptado" => "2016-08-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec837990" "palabras" => array:9 [ 0 => "Atlas" 1 => "Variations" 2 => "Small areas" 3 => "Standardisation" 4 => "Renal replacement therapy" 5 => "Haemodialysis" 6 => "Peritoneal dialysis" 7 => "Kidney transplant" 8 => "Registry" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec837991" "palabras" => array:9 [ 0 => "Atlas" 1 => "Variaciones" 2 => "Áreas pequeñas" 3 => "Estandarización" 4 => "Tratamiento sustitutivo renal" 5 => "Hemodiálisis" 6 => "Diálisis peritoneal" 7 => "Trasplante renal" 8 => "Registro" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Variations in the use of healthcare services can be defined as systematic variations of adjusted rates for certain aggregation levels of the population. The study analyses how renal replacement therapy (RRT) is used, identifying RRT variability in Catalonia from 2002 to 2012.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ecological study by health area using data from the Catalan renal registry. We present incident rates, standardised incidence ratios and prevalence, while variability was calculated through direct and indirect standardisation methods.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">From 2002 until 31/12/2012, 10,784 patients initiated RRT in Catalonia: 9238 on haemodialysis (HD) (50 treatments per 100,000 people 2010/2012), 1076 on peritoneal dialysis (PD) (8.2 treatments per 100,000 people 2010/2012) and 470 received an early kidney transplant (KT) (4.4 treatments per 100,000 people 2010/2012). Over the 10 years, the HD cumulative incidence rate fell (7%), while the PD and KT incidence rates increased (63% and 177%, respectively); both are higher in young patients (<45 years). 4750 patients received a kidney transplant in this period, 49% of which were aged between 45 and 65 years. There were no significant differences in variability in HD (RV<span class="elsevierStyleInf">5–95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.3; Empirical Bayes [EB]<span class="elsevierStyleHsp" style=""></span>∼<span class="elsevierStyleHsp" style=""></span>0), or in the prevalence of KT (RV<span class="elsevierStyleInf">5–95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.4; EB<span class="elsevierStyleHsp" style=""></span>∼<span class="elsevierStyleHsp" style=""></span>0). Nevertheless, we found significant geographical variability in PD; notably in the districts of the province of Lérida, where the number of cases observed was greater than expected (RV<span class="elsevierStyleInf">5–95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4.01; EB<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.08).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Although there was a notable rise in PD and early KT incidence rates, PD is still underused when compared to international recommendations. No territorial variability was found for HD or KT, but the use of PD was found to be higher in Lérida than in other areas. To reduce PD territorial variability and increase the uptake of this technique in the other regions, we propose 3 initiatives: the development of RRT support tools for shared decision-making, the encouragement of specific PD professional training and the promotion of PD through complementary reimbursement systems.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Las variaciones en la utilización de servicios de salud pueden definirse como variaciones sistemáticas de las tasas ajustadas para ciertos niveles de agregación de la población. Analizamos el tratamiento sustitutivo renal (TSR) e identificamos la posible variabilidad en Cataluña entre 2002 y 2012.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio ecológico por áreas de salud con datos del registro de enfermos renales de Cataluña. Presentamos tasas de incidencia, incidencia estandarizada y prevalencia. Variabilidad calculada mediante estadarización directa e indirecta.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Desde 2002 hasta el 31/12/2012, 10.784 pacientes iniciaron TSR en Cataluña: 9.238 mediante hemodiálisis (HD) (50 tratamientos/100.000 habitantes 2010/2012), 1.076 diálisis peritoneal (DP) (8,2 tratamientos/100.000 hab. 2010/2012) y 470 recibieron un trasplante renal (TR) anticipado (4,4 tratamientos/100.000 hab. 2010/2012). Durante 10 años, la tasa de incidencia acumulada de HD ha descendido (7%) y las tasas de incidencia de DP y TR han aumentado (63 y 177%); ambas son más elevadas en pacientes jóvenes (<45 años). Un total de 4.750 pacientes recibieron en ese periodo un TR; el 49% con edad de 45 a 65 años. No detectamos variabilidad entre áreas en HD (RV<span class="elsevierStyleInf">5-95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,3; empírico de Bayes [EB] ∼ 0), ni tampoco en la tasa de prevalencia en TR (RV<span class="elsevierStyleInf">5-95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,4; EB ∼ 0). Detectamos variabilidad significativa entre áreas geográficas en la indicación de DP, en las comarcas de la provincia de Lérida, donde el número de casos observados era superior a los esperados (RV<span class="elsevierStyleInf">5-95</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4,01; EB<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,08).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Hay un notable incremento en la indicación de DP y TR anticipado, aunque la DP sigue infrautilizada considerando las recomendaciones internacionales. No hemos encontrado variación territorial en la indicación de HD y los casos con TR, pero sí en la indicación de DP: el área de Lérida es la que presenta unas tasas por encima del resto de las áreas. Para reducir la variabilidad territorial en DP incrementando la indicación de esta técnica en el resto de las comarcas, proponemos 3 actuaciones: desarrollo de herramientas de decisión en TSR compartidas, potenciación de formación específica en DP de los profesionales y promoción de la DP a través de sistemas de reembolso suplementarios.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Tebé Condomí C, Arcos E, Comas J, Espallargues M, Pons JMV, Díaz JM, et al. Atlas de variaciones sistemáticas en el tratamiento sustitutivo renal en Cataluña (2002–2012). Nefrologia. 2017;37:164–171.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1775 "Ancho" => 2639 "Tamanyo" => 299674 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Geographic location of haemodialysis (HD), peritoneal dialysis (PD) and renal transplantation (RT) centres in Catalonia.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2392 "Ancho" => 1613 "Tamanyo" => 135176 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Variation statistics of standardised incidence rates of renal replacement therapy with haemodialysis by sex (top) and age groups (bottom). SCV: systematic component of variation; EB: empirical Bayes; RC: rate of change.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1156 "Ancho" => 1653 "Tamanyo" => 63307 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Crude cumulative incidence rates of renal replacement therapy with peritoneal dialysis by age group and gender (2002–2012).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 2392 "Ancho" => 1612 "Tamanyo" => 161887 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Variation statistics of standardised incidence rates of renal replacement therapy with peritoneal dialysis by sex (top) and age groups (bottom). SCV: systematic component of variation; EB: empirical Bayes; RC: rate of change.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 4378 "Ancho" => 2337 "Tamanyo" => 688767 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Map of standardised ratios for the incidence of renal replacement therapy with peritoneal dialysis (from top to bottom) in people under age of 45, between 45 and 65 years and over 65 years (2002–2012). Blank areas indicate that there are no patients treated.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1144 "Ancho" => 1579 "Tamanyo" => 63445 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Variation statistics of the standardised prevalence rates of renal transplantation for 2005, 2009 and 2012. 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Year/Month | Html | Total | |
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2024 July | 121 | 49 | 170 |
2024 June | 66 | 33 | 99 |
2024 May | 80 | 23 | 103 |
2024 April | 65 | 38 | 103 |
2024 March | 44 | 23 | 67 |
2024 February | 65 | 32 | 97 |
2024 January | 42 | 28 | 70 |
2023 December | 32 | 28 | 60 |
2023 November | 71 | 30 | 101 |
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2023 September | 62 | 30 | 92 |
2023 August | 72 | 33 | 105 |
2023 July | 44 | 25 | 69 |
2023 June | 51 | 23 | 74 |
2023 May | 56 | 155 | 211 |
2023 April | 37 | 15 | 52 |
2023 March | 68 | 19 | 87 |
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2022 November | 38 | 26 | 64 |
2022 October | 68 | 39 | 107 |
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2022 August | 82 | 50 | 132 |
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2022 June | 37 | 41 | 78 |
2022 May | 34 | 30 | 64 |
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2021 December | 60 | 52 | 112 |
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2021 January | 60 | 21 | 81 |
2020 December | 51 | 17 | 68 |
2020 November | 45 | 21 | 66 |
2020 October | 36 | 25 | 61 |
2020 September | 36 | 20 | 56 |
2020 August | 50 | 19 | 69 |
2020 July | 43 | 13 | 56 |
2020 June | 31 | 37 | 68 |
2020 May | 48 | 14 | 62 |
2020 April | 34 | 26 | 60 |
2020 March | 34 | 17 | 51 |
2020 February | 38 | 24 | 62 |
2020 January | 58 | 27 | 85 |
2019 December | 43 | 26 | 69 |
2019 November | 35 | 17 | 52 |
2019 October | 27 | 19 | 46 |
2019 September | 34 | 13 | 47 |
2019 August | 24 | 16 | 40 |
2019 July | 22 | 25 | 47 |
2019 June | 31 | 17 | 48 |
2019 May | 30 | 25 | 55 |
2019 April | 56 | 37 | 93 |
2019 March | 43 | 23 | 66 |
2019 February | 36 | 18 | 54 |
2019 January | 40 | 30 | 70 |
2018 December | 189 | 47 | 236 |
2018 November | 337 | 24 | 361 |
2018 October | 301 | 33 | 334 |
2018 September | 124 | 24 | 148 |
2018 August | 63 | 15 | 78 |
2018 July | 65 | 12 | 77 |
2018 June | 74 | 18 | 92 |
2018 May | 102 | 10 | 112 |
2018 April | 154 | 8 | 162 |
2018 March | 141 | 12 | 153 |
2018 February | 155 | 3 | 158 |
2018 January | 167 | 9 | 176 |
2017 December | 182 | 4 | 186 |
2017 November | 128 | 14 | 142 |
2017 October | 42 | 12 | 54 |
2017 September | 51 | 9 | 60 |
2017 August | 97 | 14 | 111 |
2017 July | 71 | 13 | 84 |
2017 June | 61 | 13 | 74 |
2017 May | 75 | 15 | 90 |