was read the article
array:25 [ "pii" => "S2013251416301328" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2016.05.008" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "227" "copyright" => "Sociedad Española de Nefrología" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2016;36:719-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3561 "formatos" => array:3 [ "EPUB" => 324 "HTML" => 2716 "PDF" => 521 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S0211699516300789" "issn" => "02116995" "doi" => "10.1016/j.nefro.2016.05.014" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "227" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia. 2016;36:719-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5121 "formatos" => array:3 [ "EPUB" => 402 "HTML" => 3836 "PDF" => 883 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Gaucher disease and Lupus: A rare association?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "719" "paginaFinal" => "721" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Gaucher y lupus: ¿una rara asociación?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Teresa Jerónimo, Ana Cabrita, Ana Pimentel, Joana Vidinha, André Fragoso, Viriato Santos, Idalécio Bernardo, Helena Viana, Fernanda Carvalho, Helena Brito, Mário Lázaro, Pedro Leão Neves" "autores" => array:12 [ 0 => array:2 [ "nombre" => "Teresa" "apellidos" => "Jerónimo" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Cabrita" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Pimentel" ] 3 => array:2 [ "nombre" => "Joana" "apellidos" => "Vidinha" ] 4 => array:2 [ "nombre" => "André" "apellidos" => "Fragoso" ] 5 => array:2 [ "nombre" => "Viriato" "apellidos" => "Santos" ] 6 => array:2 [ "nombre" => "Idalécio" "apellidos" => "Bernardo" ] 7 => array:2 [ "nombre" => "Helena" "apellidos" => "Viana" ] 8 => array:2 [ "nombre" => "Fernanda" "apellidos" => "Carvalho" ] 9 => array:2 [ "nombre" => "Helena" "apellidos" => "Brito" ] 10 => array:2 [ "nombre" => "Mário" "apellidos" => "Lázaro" ] 11 => array:2 [ "nombre" => "Pedro" "apellidos" => "Leão Neves" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2013251416301328" "doi" => "10.1016/j.nefroe.2016.05.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416301328?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300789?idApp=UINPBA000064" "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516300789/v1_201611240148/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2013251417300123" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2017.01.009" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "255" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2016;36:721-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3639 "formatos" => array:3 [ "EPUB" => 330 "HTML" => 2652 "PDF" => 657 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Severe Parkinsonism with respiratory failure in peritoneal dialysis patient" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "721" "paginaFinal" => "722" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Parkinsonismo severo con insuficiencia respiratoria en paciente de diálisis peritoneal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Angel Gallegos-Villalobos, Jorge Ruiz-Criado, Adrián Rodríguez, Franz Fernandez-Rodríguez, Antonio Gascón" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Angel" "apellidos" => "Gallegos-Villalobos" ] 1 => array:2 [ "nombre" => "Jorge" "apellidos" => "Ruiz-Criado" ] 2 => array:2 [ "nombre" => "Adrián" "apellidos" => "Rodríguez" ] 3 => array:2 [ "nombre" => "Franz" "apellidos" => "Fernandez-Rodríguez" ] 4 => array:2 [ "nombre" => "Antonio" "apellidos" => "Gascón" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699516301205" "doi" => "10.1016/j.nefro.2016.09.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516301205?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300123?idApp=UINPBA000064" "url" => "/20132514/0000003600000006/v1_201702210030/S2013251417300123/v1_201702210030/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2013251417300044" "issn" => "20132514" "doi" => "10.1016/j.nefroe.2017.01.004" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "215" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Nefrologia (English Version). 2016;36:718-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3377 "formatos" => array:3 [ "EPUB" => 328 "HTML" => 2130 "PDF" => 919 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "<span class="elsevierStyleItalic">Blanket orders</span>, an unadvisable practise, yet more and more frequent" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "718" "paginaFinal" => "719" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Blanket orders</span>, práctica desaconsejada pero cada vez más frecuente" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Anunciación González López, Álvaro Nava Rebollo, Beatriz Andrés Martín, Ángel Chocarro Martínez, Francisco Herrera Gómez, Henar Santana Zapatero, Julia Diego Martín, Cipriano Escaja Muga, Hugo Díaz Molina, Jesús Grande Villoria" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Anunciación" "apellidos" => "González López" ] 1 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Nava Rebollo" ] 2 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Andrés Martín" ] 3 => array:2 [ "nombre" => "Ángel" "apellidos" => "Chocarro Martínez" ] 4 => array:2 [ "nombre" => "Francisco" "apellidos" => "Herrera Gómez" ] 5 => array:2 [ "nombre" => "Henar" "apellidos" => "Santana Zapatero" ] 6 => array:2 [ "nombre" => "Julia" "apellidos" => "Diego Martín" ] 7 => array:2 [ "nombre" => "Cipriano" "apellidos" => "Escaja Muga" ] 8 => array:2 [ "nombre" => "Hugo" "apellidos" => "Díaz Molina" ] 9 => array:2 [ "nombre" => "Jesús" "apellidos" => "Grande Villoria" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0211699516300662" "doi" => "10.1016/j.nefro.2016.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300662?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300044?idApp=UINPBA000064" "url" => "/20132514/0000003600000006/v1_201702210030/S2013251417300044/v1_201702210030/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Gaucher disease and Lupus: A rare association?" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "719" "paginaFinal" => "721" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Teresa Jerónimo, Ana Cabrita, Ana Pimentel, Joana Vidinha, André Fragoso, Viriato Santos, Idalécio Bernardo, Helena Viana, Fernanda Carvalho, Helena Brito, Mário Lázaro, Pedro Leão Neves" "autores" => array:12 [ 0 => array:4 [ "nombre" => "Teresa" "apellidos" => "Jerónimo" "email" => array:1 [ 0 => "teresa_jeronimo@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ana" "apellidos" => "Cabrita" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Ana" "apellidos" => "Pimentel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Joana" "apellidos" => "Vidinha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "André" "apellidos" => "Fragoso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Viriato" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Idalécio" "apellidos" => "Bernardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "Helena" "apellidos" => "Viana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "Fernanda" "apellidos" => "Carvalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "Helena" "apellidos" => "Brito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 10 => array:3 [ "nombre" => "Mário" "apellidos" => "Lázaro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 11 => array:3 [ "nombre" => "Pedro" "apellidos" => "Leão Neves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Nephrology Department, Centro Hospitalar do Algarve – Faro Unit, Rua Leão Penedo, 8000-386 Faro, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Renal Pathology Laboratory, Nephrology Department, Hospital Curry Cabral, Rua da Beneficência, n.° 8, 1069-166 Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Internal Medicine Department, Centro Hospitalar do Algarve – Faro Unit, Rua Leão Penedo, 8000-386 Faro, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Gaucher y lupus: ¿una rara asociación?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gaucher disease (GD), is an autosomal recessive lysosomal storage disease that is due to mutations in the glucocerebrosidase (GC) gene, with a prevalence of 1/57,000 to 1/75,000 births worldwide<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and significantly more common among the Ashkenazi Jewish heritage.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> GD is categorized into three clinical types<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and the clinical manifestations result from the accumulation of the lipid-laden macrophages in the spleen, liver, bone, bone marrow,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> leading to impairment of central nervous system in the most severe cases.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although several reports are available related to the risk of GD patients developing other diseases like Parkinson's disease<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and increased rates of malignancies, particularly hematologic,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> systemic lupus erythematous (SLE) has not been described in association with GD.</p><p id="par0015" class="elsevierStylePara elsevierViewall">We report a case of a 32-year-old Caucasian woman diagnosed with GD type 1 at 17 years-old. She had a grandmother with GD, an uncle with SLE and a cousin with rheumatoid arthritis. There is no known Jewish heritage in her family. She was medicated with velaglucerase.</p><p id="par0020" class="elsevierStylePara elsevierViewall">With 30 years old, the patient developed malar-rash and chest eczema, associated with sun exposure. One year after she noticed worsening asthenia, anorexia, nausea, hair loss, myalgias, bilateral gonalgia, oral ulcers, Raynaud syndrome and arterial hypertension (TA 140/90<span class="elsevierStyleHsp" style=""></span>mmHg). The patient was referred to the nephrology unit with peripheral edema and the laboratory investigation showed parameters of ferropenic anemia (without signs of hemolysis), leukopenia, thrombocytopenia, elevated seric creatinine, hypoalbuminemia, active urinary sediment and nephrotic-range proteinuria observed in the 24<span class="elsevierStyleHsp" style=""></span>h urine sample (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The immune assays revealed positive antinuclear antibodies (ANA) and anti-Sjögren's-syndrome-related antigen A, elevated immunoglobulin (Ig) G (20.7<span class="elsevierStyleHsp" style=""></span>g/L) and IgA (4.64<span class="elsevierStyleHsp" style=""></span>g/L), circulating immunocomplexes (>100<span class="elsevierStyleHsp" style=""></span>μg<span class="elsevierStyleHsp" style=""></span>Eq/mL) and low serum complement (C3 0.16<span class="elsevierStyleHsp" style=""></span>g/L, C4 0.021<span class="elsevierStyleHsp" style=""></span>g/L, C1q 0.208<span class="elsevierStyleHsp" style=""></span>g/L). The complementary immunologic and serologic study was negative. Renal and abdominal ultrasounds showed normal sized kidneys, increased cortical echogenicity with maintained differentiation and mild/moderate homogeneous hepatosplenomegaly. Echocardiogram revealed thickened pericardium and nuclear magnetic resonance of the inferior members showed bone alterations and moderate intra-articular left knee and mild right knee effusion.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Kidney biopsy established the diagnosis of class IV-G lupus nephritis (LN) and the treatment according to KDIGO (Kidney Disease: Improving Global Outcomes) guideline<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> was started. Hydroxychloroquine was redrawn due to gastric intolerance. She was discharged 1 month after admission with serum creatinine 1.5<span class="elsevierStyleHsp" style=""></span>mg/dL, proteinuria 4500<span class="elsevierStyleHsp" style=""></span>mg observed in the 24<span class="elsevierStyleHsp" style=""></span>h urine sample (mg/24<span class="elsevierStyleHsp" style=""></span>h), complement levels arose and albuminemia was at the normal range (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Six months after discharge the patient is clinically stable, with normal renal function, proteinuria of 341<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h and an amelioration of complement. Anti-double stranded DNA was positive for the first time 6 months after discharge (182<span class="elsevierStyleHsp" style=""></span>U/mL) and decreased to 83<span class="elsevierStyleHsp" style=""></span>U/mL in the following 6 months (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0030" class="elsevierStylePara elsevierViewall">We describe this case of a patient with GD and SLE simultaneously with the purpose of highlighting a possible immunologic proximity between these two diseases. Although the presence of renal pathology in GD is rather rare, it consists of varying degrees of proteinuria with or without renal insufficiency and it has been described in some patients associated with the accumulation of GC in form of Gaucher bodies in glomerular, mesangial, endothelial and interstitial cells of the kidney.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> It has been suggested that progressive accumulation of GC may trigger macrophage activation leading to chronic stimulation of the immune system.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Increasing clinical evidence suggests that the pathophysiology of classic GD is more complex and involves system-wide dysfunction of cell types other than macrophages.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Therefore, the immunological disturbances that occur in GD may function as a trigger to the development of SLE, bringing up the already existing doubt that the defects in lipid metabolism could contribute to the development of autoimmunity. In this particular case, clinical and laboratory results could led to a diagnosis of SLE: presence of 4 or more criteria, at least one clinical and one laboratorial Systemic Lupus International Collaborating Clinic (SLICC) criteria. However, and besides the clinical manifestations of malar rash associated with sun exposure, other like arthralgia, pancytopenia and hepatosplenomegaly were easily confounded with GD manifestations and the SLE diagnosis was not achieved until the renal manifestations occurred. The kidney biopsy revealing LN with positive ANA was preponderant to the diagnosis of SLE, according to SLICC criteria. Determining the class of LN was also important to guide the treatment by the histologic subtype, as the clinical presentation may not accurately reflect the severity of the histologic findings, and there was a positive clinical and laboratorial response.</p><p id="par0035" class="elsevierStylePara elsevierViewall">However, the relationship between GD and SLE is not yet established. The involvement of immune cells has been implicated, but the underlying molecular defect is poorly understood. Further studies are necessary to highlight the possible immunologic proximity between these two rare conditions.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration</span><p id="par0040" class="elsevierStylePara elsevierViewall">Informed consent to publish individual data was obtained from the patient.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Declaration" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ANA, antinuclear antibodies; anti-SSA, anti-Sjögren's-syndrome-related antigen A; anti-dsDNA, anti-double stranded DNA; C3, complement 3; C4, complement 4.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Admission \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Discharge \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">6 months \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">12 months \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hb (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leukcocytes (×10<span class="elsevierStyleSup">9</span>/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2900 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7400 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5900 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4500 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelets (×10<span class="elsevierStyleSup">9</span>/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">87,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">168,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">237,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">367,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.38<span class="elsevierStyleHsp" style=""></span>→<span class="elsevierStyleHsp" style=""></span>2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Albumin (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary sediment – erythrocyts (μL<span class="elsevierStyleSup">−1</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">225 (15% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (8% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 (4% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary proteins (mg/24<span class="elsevierStyleHsp" style=""></span>h) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7600 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4500 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">283 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ANA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-SSA (UA/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">786 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-dsDNA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">182 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">83 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C3 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C4 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.021 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.052 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.085 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1349489.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Laboratory parameters.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of lysosomal storage disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.J. Meikle" 1 => "J.J. Hopwood" 2 => "A.E. Clague" 3 => "W.F. Carey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JAMA" "fecha" => "1999" "volumen" => "281" "paginaInicial" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9918480" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucosylceramide lipidosis – Gaucher disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Beutler" 1 => "G.A. Grabowski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "The metabolic and molecular bases of inherited diseases" "paginaInicial" => "3635" "paginaFinal" => "3668" "edicion" => "8th ed." "serieFecha" => "2001" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gaucher disease: understanding the molecular pathogenesis of sphingolipidoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.M. Cox" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Inherit Metab Dis" "fecha" => "2001" "volumen" => "24" "numero" => "Suppl. 2" "paginaInicial" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11758671" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gaucher disease, enzymology, genetics, and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.A. Grabowski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Adv Hum Genet" "fecha" => "1993" "volumen" => "21" "paginaInicial" => "377" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8317294" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Aharon-Peretz" 1 => "H. Rosenbaum" 2 => "R. Gershoni-Baruch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa033277" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "351" "paginaInicial" => "1972" "paginaFinal" => "1977" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15525722" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expanding spectrum of the association between type 1 Gaucher disease and cancers: a series of patients with up to 3 sequential cancers of multiple types – correlation with genotype and phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Lo" 1 => "P. Stein" 2 => "S. Mullaly" 3 => "M. Bar" 4 => "D. Jain" 5 => "G.M. Pastores" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajh.21684" "Revista" => array:5 [ "tituloSerie" => "Am J Hematol" "fecha" => "2010" "volumen" => "85" "paginaInicial" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20425796" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "KDIGO clinical practice guideline for glomerulonephritis" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kidney Int Suppl" "fecha" => "2012" "volumen" => "2" "paginaInicial" => "221" "paginaFinal" => "232" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glomerular involvement in storage diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Rosenmann" 1 => "A. Aviram" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/path.1711110111" "Revista" => array:6 [ "tituloSerie" => "J Pathol" "fecha" => "1973" "volumen" => "111" "paginaInicial" => "61" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4271275" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gaucher's disease: a disease with chronic stimulation of the immune system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Shoenfield" 1 => "L.A. Gallant" 2 => "M. Shaklai" 3 => "E. Livni" 4 => "M. Djaldetti" 5 => "J. Pinkhas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "1982" "volumen" => "106" "paginaInicial" => "388" "paginaFinal" => "391" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7049116" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.K. Mistry" 1 => "J. Liu" 2 => "M. Yang" 3 => "T. Nottoli" 4 => "J. McGrath" 5 => "D. Jain" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.1003308107" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2010" "volumen" => "107" "paginaInicial" => "19473" "paginaFinal" => "19478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20962279" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003600000006/v1_201702210030/S2013251416301328/v1_201702210030/en/main.assets" "Apartado" => array:4 [ "identificador" => "35436" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003600000006/v1_201702210030/S2013251416301328/v1_201702210030/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416301328?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 2 | 5 |
2024 October | 58 | 67 | 125 |
2024 September | 56 | 36 | 92 |
2024 August | 70 | 66 | 136 |
2024 July | 65 | 29 | 94 |
2024 June | 87 | 43 | 130 |
2024 May | 83 | 41 | 124 |
2024 April | 75 | 26 | 101 |
2024 March | 54 | 24 | 78 |
2024 February | 40 | 40 | 80 |
2024 January | 91 | 27 | 118 |
2023 December | 28 | 18 | 46 |
2023 November | 46 | 25 | 71 |
2023 October | 44 | 28 | 72 |
2023 September | 47 | 29 | 76 |
2023 August | 60 | 20 | 80 |
2023 July | 34 | 18 | 52 |
2023 June | 47 | 18 | 65 |
2023 May | 59 | 35 | 94 |
2023 April | 24 | 17 | 41 |
2023 March | 40 | 18 | 58 |
2023 February | 50 | 19 | 69 |
2023 January | 48 | 30 | 78 |
2022 December | 63 | 33 | 96 |
2022 November | 76 | 30 | 106 |
2022 October | 54 | 46 | 100 |
2022 September | 56 | 31 | 87 |
2022 August | 54 | 44 | 98 |
2022 July | 75 | 41 | 116 |
2022 June | 93 | 23 | 116 |
2022 May | 72 | 37 | 109 |
2022 April | 90 | 44 | 134 |
2022 March | 97 | 40 | 137 |
2022 February | 107 | 33 | 140 |
2022 January | 61 | 32 | 93 |
2021 December | 67 | 55 | 122 |
2021 November | 54 | 33 | 87 |
2021 October | 68 | 61 | 129 |
2021 September | 59 | 47 | 106 |
2021 August | 58 | 35 | 93 |
2021 July | 74 | 39 | 113 |
2021 June | 38 | 48 | 86 |
2021 May | 47 | 44 | 91 |
2021 April | 123 | 47 | 170 |
2021 March | 59 | 38 | 97 |
2021 February | 51 | 28 | 79 |
2021 January | 63 | 22 | 85 |
2020 December | 41 | 14 | 55 |
2020 November | 42 | 14 | 56 |
2020 October | 30 | 23 | 53 |
2020 September | 28 | 14 | 42 |
2020 August | 47 | 20 | 67 |
2020 July | 40 | 16 | 56 |
2020 June | 45 | 23 | 68 |
2020 May | 43 | 16 | 59 |
2020 April | 37 | 20 | 57 |
2020 March | 39 | 20 | 59 |
2020 February | 46 | 31 | 77 |
2020 January | 42 | 18 | 60 |
2019 December | 48 | 26 | 74 |
2019 November | 43 | 25 | 68 |
2019 October | 49 | 13 | 62 |
2019 September | 35 | 17 | 52 |
2019 August | 28 | 12 | 40 |
2019 July | 28 | 22 | 50 |
2019 June | 31 | 14 | 45 |
2019 May | 29 | 10 | 39 |
2019 April | 65 | 26 | 91 |
2019 March | 38 | 24 | 62 |
2019 February | 45 | 18 | 63 |
2019 January | 43 | 19 | 62 |
2018 December | 182 | 42 | 224 |
2018 November | 299 | 17 | 316 |
2018 October | 281 | 23 | 304 |
2018 September | 129 | 9 | 138 |
2018 August | 99 | 21 | 120 |
2018 July | 70 | 17 | 87 |
2018 June | 62 | 15 | 77 |
2018 May | 76 | 23 | 99 |
2018 April | 78 | 6 | 84 |
2018 March | 54 | 5 | 59 |
2018 February | 97 | 7 | 104 |
2018 January | 132 | 5 | 137 |
2017 December | 184 | 8 | 192 |
2017 November | 55 | 8 | 63 |
2017 October | 39 | 4 | 43 |
2017 September | 47 | 10 | 57 |
2017 August | 50 | 6 | 56 |
2017 July | 48 | 4 | 52 |
2017 June | 51 | 7 | 58 |
2017 May | 51 | 10 | 61 |
2017 April | 33 | 6 | 39 |
2017 March | 28 | 3 | 31 |
2017 February | 23 | 7 | 30 |