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with a good response to antibiotic treatment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This case involves a 63-year-old female patient&#44; with hypertension&#44; type 2 diabetes and a kidney transplant from a cadaver donor 3 years earlier&#59; she attended the emergency room for a two day history of generalised skin lesions&#44; fever and sore throat&#46; Relevant history included a post-transplant intestinal ischaemia resolved with intestinal resection&#46; She is currently being treated with mycophenolate mofetil &#40;MMF&#41; and tacrolimus&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On arrival she had a temperature of 38<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; blood pressure of 126&#47;75<span class="elsevierStyleHsp" style=""></span>mmHg and heart rate of 81<span class="elsevierStyleHsp" style=""></span>bpm&#46; On physical examination there were painful vesicular-bullous skin lesions of haemorrhagic content on the right leg&#44; abdomen and left arm&#44; about 3&#8211;25<span class="elsevierStyleHsp" style=""></span>mm in diameter&#44; and punctate erythematous lesions on the nasolabial folds and tongue blisters&#44; and on the oral mucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The laboratory tests showed haemoglobin 11&#46;3<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; platelets 210&#44;000&#44; leukocytes 1780 &#40;neutrophils 11&#46;2&#37;&#44; lymphocytes 23&#37; and monocytes 60&#46;7&#37;&#41;&#44; glucose 140<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; creatinine 1&#46;95<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;baseline 1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; urea 93<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; potassium 3&#46;31<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#44; procalcitonin 1&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; CRP 6&#46;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; pH in venous blood gases 7&#46;39&#44; <span class="elsevierStyleSmallCaps">l</span>-lactate 2<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#46; In the preceding days she had received empirical antibiotic therapy with amoxicillin-clavulanic acid for a sore throat&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Suspecting ecthyma gangrenosum&#44; the patient was admitted and placed on broad-spectrum antibiotics &#40;daptomycin&#44; ceftazidime and Meropenem<span class="elsevierStyleSup">&#174;</span>&#41; after obtaining blood cultures&#44; a wound culture and a biopsy of the lesion in Dermatology&#46; Also&#44; immunosuppression was reduced with a temporary suspension of MMF&#46; During admission&#44; the patient progressed favourably&#44; and the skin lesion cultures were positive for <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#59; the daptomycin was stopped after determining sensitivity by an antibiogram &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; In addition to antibiotic therapy&#44; one of the bullous lesions was drained&#44; and copper sulfate and silver sulfadiazine were applied topically&#46; After 7 days of treatment&#44; the lesions improved and the lab test results normalised &#40;Cr 0&#46;79<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and leukocytes 3&#44;000<span class="elsevierStyleHsp" style=""></span>&#956;&#47;l&#41;&#44; and so the patient was discharged&#46; In follow-up&#44; and after completing 3 weeks of antibiotic therapy&#44; the patient&#39;s symptoms resolved completely&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">We therefore report here an exceptional case of ecthyma gangrenosum in a patient with a renal graft that functioned for 3 years&#44; with a positive outcome after treatment&#44; despite the initial condition of neutropenia and immunosuppression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">There are few data on ecthyma gangrenosum published to date&#44; with the majority of them concerning patients with haematological diseases in paediatric or immunosuppressed patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a> As for kidney transplant patients&#44; 3 cases have been reported so far&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#8211;6</span></a> In all 3 cases the outcome has been favourable&#44; after targeted antibiotic treatment&#44; whether or not combined with debridement of the lesions&#44;&#46; In one of these cases the initial evolution was torpid&#44; with septic shock&#44; and required admission to the intensive care unit and repeated surgical debridement&#46; The patient improved thereafter&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Therefore it seems that starting treatment early with broad-spectrum antibiotics &#40;which especially covers <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#41; when these lesions are suspected&#44; as well as granulocyte-colony stimulating factor and surgery if necessary&#44; affects how the condition&#44; which is potentially fatal&#44; develops&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">An association between neutropenia and increased mortality has been documented in patients with ecthyma gangrenosum&#44; with neutropenia being one of the main factors for poor prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> In a series of 43 cases of immunocompetent paediatric patients who developed sepsis due to <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; 9 out of 10 patients who died had presented with leukopenia at the onset of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> It is noteworthy that in reviewing cases in the immunocompetent general population&#44; the evolution of the disease is more torpid&#44; with increased mortality in patients with a renal transplant on immunosuppressive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; the clinical suspicion of ecthyma gangrenosum in patients with a renal transplant and suggestive lesions requires an initial aggressive approach with broad-spectrum antibiotics&#44; granulocyte-colony stimulating factor and surgical debridement&#44; if necessary&#44; in order to avoid major life-threatening complications&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have not received any funding to complete this study&#46;</p></span></span>"
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Letter to the Editor
Ecthyma gangrenosum in a renal transplant recipient
Ectima gangrenoso en paciente portadora de trasplante renal
Begoña Santos, Marta Sanz, Almudena Nuñez, Lech Onofre Mayor, Borja Quiroga
Corresponding author
borjaqg@gmail.com

Corresponding author.
Servicio de Nefrología, Hospital Universitario de La Princesa, Madrid, Spain
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with a good response to antibiotic treatment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This case involves a 63-year-old female patient&#44; with hypertension&#44; type 2 diabetes and a kidney transplant from a cadaver donor 3 years earlier&#59; she attended the emergency room for a two day history of generalised skin lesions&#44; fever and sore throat&#46; Relevant history included a post-transplant intestinal ischaemia resolved with intestinal resection&#46; She is currently being treated with mycophenolate mofetil &#40;MMF&#41; and tacrolimus&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On arrival she had a temperature of 38<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; blood pressure of 126&#47;75<span class="elsevierStyleHsp" style=""></span>mmHg and heart rate of 81<span class="elsevierStyleHsp" style=""></span>bpm&#46; On physical examination there were painful vesicular-bullous skin lesions of haemorrhagic content on the right leg&#44; abdomen and left arm&#44; about 3&#8211;25<span class="elsevierStyleHsp" style=""></span>mm in diameter&#44; and punctate erythematous lesions on the nasolabial folds and tongue blisters&#44; and on the oral mucosa &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The laboratory tests showed haemoglobin 11&#46;3<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; platelets 210&#44;000&#44; leukocytes 1780 &#40;neutrophils 11&#46;2&#37;&#44; lymphocytes 23&#37; and monocytes 60&#46;7&#37;&#41;&#44; glucose 140<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; creatinine 1&#46;95<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;baseline 1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; urea 93<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; potassium 3&#46;31<span class="elsevierStyleHsp" style=""></span>mEq&#47;L&#44; procalcitonin 1&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; CRP 6&#46;30<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; pH in venous blood gases 7&#46;39&#44; <span class="elsevierStyleSmallCaps">l</span>-lactate 2<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#46; In the preceding days she had received empirical antibiotic therapy with amoxicillin-clavulanic acid for a sore throat&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Suspecting ecthyma gangrenosum&#44; the patient was admitted and placed on broad-spectrum antibiotics &#40;daptomycin&#44; ceftazidime and Meropenem<span class="elsevierStyleSup">&#174;</span>&#41; after obtaining blood cultures&#44; a wound culture and a biopsy of the lesion in Dermatology&#46; Also&#44; immunosuppression was reduced with a temporary suspension of MMF&#46; During admission&#44; the patient progressed favourably&#44; and the skin lesion cultures were positive for <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#59; the daptomycin was stopped after determining sensitivity by an antibiogram &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; In addition to antibiotic therapy&#44; one of the bullous lesions was drained&#44; and copper sulfate and silver sulfadiazine were applied topically&#46; After 7 days of treatment&#44; the lesions improved and the lab test results normalised &#40;Cr 0&#46;79<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and leukocytes 3&#44;000<span class="elsevierStyleHsp" style=""></span>&#956;&#47;l&#41;&#44; and so the patient was discharged&#46; In follow-up&#44; and after completing 3 weeks of antibiotic therapy&#44; the patient&#39;s symptoms resolved completely&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">We therefore report here an exceptional case of ecthyma gangrenosum in a patient with a renal graft that functioned for 3 years&#44; with a positive outcome after treatment&#44; despite the initial condition of neutropenia and immunosuppression&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">There are few data on ecthyma gangrenosum published to date&#44; with the majority of them concerning patients with haematological diseases in paediatric or immunosuppressed patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a> As for kidney transplant patients&#44; 3 cases have been reported so far&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#8211;6</span></a> In all 3 cases the outcome has been favourable&#44; after targeted antibiotic treatment&#44; whether or not combined with debridement of the lesions&#44;&#46; In one of these cases the initial evolution was torpid&#44; with septic shock&#44; and required admission to the intensive care unit and repeated surgical debridement&#46; The patient improved thereafter&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Therefore it seems that starting treatment early with broad-spectrum antibiotics &#40;which especially covers <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#41; when these lesions are suspected&#44; as well as granulocyte-colony stimulating factor and surgery if necessary&#44; affects how the condition&#44; which is potentially fatal&#44; develops&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">An association between neutropenia and increased mortality has been documented in patients with ecthyma gangrenosum&#44; with neutropenia being one of the main factors for poor prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> In a series of 43 cases of immunocompetent paediatric patients who developed sepsis due to <span class="elsevierStyleItalic">P&#46; aeruginosa</span>&#44; 9 out of 10 patients who died had presented with leukopenia at the onset of symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> It is noteworthy that in reviewing cases in the immunocompetent general population&#44; the evolution of the disease is more torpid&#44; with increased mortality in patients with a renal transplant on immunosuppressive therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; the clinical suspicion of ecthyma gangrenosum in patients with a renal transplant and suggestive lesions requires an initial aggressive approach with broad-spectrum antibiotics&#44; granulocyte-colony stimulating factor and surgical debridement&#44; if necessary&#44; in order to avoid major life-threatening complications&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have not received any funding to complete this study&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous lesions on the arm &#40;A&#41; and on the back of the leg &#40;B&#41;&#44; corresponding to ecthyma gangrenosum&#46;</p>"
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Article information
ISSN: 20132514
Original language: English
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Idiomas
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