array:25 [
  "pii" => "S201325141630089X"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2016.10.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-07-01"
  "aid" => "180"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2016;36:376-80"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3898
    "formatos" => array:3 [
      "EPUB" => 316
      "HTML" => 2964
      "PDF" => 618
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699516300121"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2016.03.009"
      "estado" => "S300"
      "fechaPublicacion" => "2016-07-01"
      "aid" => "180"
      "copyright" => "Sociedad Española de Nefrología"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2016;36:376-80"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7656
        "formatos" => array:3 [
          "EPUB" => 363
          "HTML" => 6131
          "PDF" => 1162
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo especial</span>"
        "titulo" => "Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "376"
            "paginaFinal" => "380"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "PrEFiNe Plan&#58; Strategic plan for Fabry diseases in Nephrology"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2638
                "Ancho" => 3167
                "Tamanyo" => 411469
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Acciones&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46;D&#46; del Pino, A&#46; Ortiz, R&#46; Torra, D&#46; Hernandez"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;D&#46;"
                "apellidos" => "del Pino"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Ortiz"
              ]
              2 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Torra"
              ]
              3 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Hernandez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S201325141630089X"
          "doi" => "10.1016/j.nefroe.2016.10.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630089X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300121?idApp=UINPBA000064"
      "url" => "/02116995/0000003600000004/v2_201611160150/S0211699516300121/v2_201611160150/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251416300888"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "505"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:381-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4475
      "formatos" => array:3 [
        "EPUB" => 315
        "HTML" => 3002
        "PDF" => 1158
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "COSMOS Project&#58; Haemodialysis scenario in Europe"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "381"
          "paginaFinal" => "388"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Proyecto COSMOS&#58; escenario de la hemodi&#225;lisis en Europa"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jorge B&#46; Cannata-And&#237;a, Jos&#233; Luis Fern&#225;ndez-Mart&#237;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Jorge B&#46;"
              "apellidos" => "Cannata-And&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Fern&#225;ndez-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021169951630011X"
        "doi" => "10.1016/j.nefro.2016.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951630011X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300888?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000004/v1_201612030031/S2013251416300888/v1_201612030031/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251416300700"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.08.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "175"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "ssu"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:368-75"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7564
      "formatos" => array:3 [
        "EPUB" => 371
        "HTML" => 6254
        "PDF" => 939
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Bone mineral disorder in chronic kidney disease&#58; Klotho and FGF23&#59; cardiovascular implications"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "368"
          "paginaFinal" => "375"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad &#243;seo mineral relacionada con la enfermedad renal cr&#243;nica&#58; Klotho y FGF23&#59; implicaciones cardiovasculares"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1764
              "Ancho" => 2332
              "Tamanyo" => 295812
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Diagram of BMD-CKD abnormalities and involvement in vascular calcification&#46; CVD&#58; cardiovascular disease&#59; uP&#58; urine phosphorus&#59; pP&#58; plasma phosphorus&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Laura Salanova Villanueva, Carmen S&#225;nchez Gonz&#225;lez, Jos&#233; Antonio S&#225;nchez Tomero, Abelardo Aguilera, Esther Ortega Junco"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Salanova Villanueva"
            ]
            1 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "S&#225;nchez Gonz&#225;lez"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Antonio"
              "apellidos" => "S&#225;nchez Tomero"
            ]
            3 => array:2 [
              "nombre" => "Abelardo"
              "apellidos" => "Aguilera"
            ]
            4 => array:2 [
              "nombre" => "Esther"
              "apellidos" => "Ortega Junco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699516300078"
        "doi" => "10.1016/j.nefro.2016.01.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300078?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300700?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000004/v1_201612030031/S2013251416300700/v1_201612030031/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
    "titulo" => "PrEFiNe Plan&#58; Strategic plan for Fabry&#39;s diseases in Nephrology"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "376"
        "paginaFinal" => "380"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;D&#46; del Pino, A&#46; Ortiz, R&#46; Torra, D&#46; Hernandez"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;D&#46;"
            "apellidos" => "del Pino"
            "email" => array:2 [
              0 => "mdpinoypino&#64;gmail&#46;com"
              1 => "http&#58;&#47;&#47;www&#46;prefine&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Ortiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Torra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Hernandez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Torrec&#225;rdenas&#44; Almer&#237;a&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Fundaci&#243;n Jimenez D&#237;az&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servici&#243; de Nefrolog&#237;a&#44; Fundaci&#243;n Puigvert&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Regional&#44; M&#225;laga&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2638
            "Ancho" => 3167
            "Tamanyo" => 386114
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Actions&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Fabry&#39;s disease &#40;FD&#41; is a lysosomal disease that is characterised by a deficiency in &#945;-galactosidase A&#44; an enzyme that causes glycosphingolipids&#44; mainly globotriaosylceramide &#40;Gb3&#41;&#44; to be deposited in the vascular endothelium and other tissues&#46; It is a progressive disease that causes manifestations in the kidneys&#44; heart&#44; nervous system&#44; skin&#44; eyes and other systems&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is considered to be a rare disease&#44; as it affects 1 in 40&#44;000&#8211;238&#44;000 males&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; studies conducted using neonatal screening have observed a greater incidence&#44; of 1&#47;3100 to 1&#47;4100 live births for late-onset forms and 1&#47;37&#44;000 for classic phenotypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;6</span></a> Obviously&#44; its frequency is greater in high-risk populations such as the population affected by chronic kidney disease &#40;CKD&#41; that requires dialysis or the population suffering from by left ventricular hypertrophy or stroke&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a> Life expectancy is normally shortened by 20 years in men<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a> and 15 years in women&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a> One of the main causes of death in patients with FD is renal failure and it occurs very early&#44; in the fourth or fifth decade of life&#44; particularly in males&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">One analysis of patients with FD determined that more than 25&#37; had been diagnosed incorrectly initially<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> and that their diagnosis took an average of 12 years to confirm&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> Diagnosis tends to be delayed by at least 3 years&#44; but it often takes 20 years after the onset of signs and symptoms&#46; Some patients have even experienced delays of more than 50 years&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> Patients with FD and already impaired renal function have a more unfavourable prognosis than those without it&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In clinical practice there is no unanimous agreement for including FD as part of the differential diagnosis of patients with CKD in any stage&#46; This makes it difficult to diagnose the disease early&#44; identify at-risk family relatives and prevent other secondary and potentially deadly complications of the disease&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As generally occurs with rare diseases&#44; part of the problem may lie in limited awareness of the disease such that a diagnosis of FD may not be considered as part of the diagnostic algorithm for patients with CKD&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The PrEFiNE plan was created with the aim of improving knowledge and recognition of FD among all nephrologists&#44; which would allow an early diagnosis of the disease and an early approach to patients who have it&#46; The aims of this plan are many and range from evaluating current knowledge of FD and establishing its prevalence in patients with CKD &#40;dialysis&#44; transplant and stage 3&#8211;5 CKD predialysis&#41;&#59; evaluating the impact of FD from a healthcare-related&#44; sociological and economic point of view&#59; improving knowledge of FD through specific training in the disease&#59; detecting potential unmet needs in the approach to FD&#59; and&#44; finally&#44; developing a prioritised action plan to improve the needs detected and reduce the repercussions of the disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Therefore&#44; this multi-centre project&#44; encompassing all of Spain&#44; is being proposed through a broad training and information campaign&#44; with continuing education and enhancement of different research studies&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The intention of this article is to spread information on the design of this project and some of its activities to offer it as a platform that facilitates and stimulates research on and knowledge of FD among Spanish nephrologists&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methodology</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">General design</span><p id="par0045" class="elsevierStylePara elsevierViewall">The project will have an advisory committee headed by the chairperson of the Spanish Society of Nephrology &#40;SEN&#41; who will be in charge of driving&#44; promoting and reviewing the project&#59; advising on the proposed aims&#59; and involving all participants effectively&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A scientific committee will validate the general approach of the project and the actions and studies to be carried out&#59; advise on the mode in which each action will be performed&#44; thereby ensuring maximum scientific rigour&#59; select and produce required training materials &#40;in person and online&#41;&#44; review the results obtained&#59; and propose and reach an agreement on future lines of research&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Regional committees will coordinate and execute the training activities required to improve knowledge of FD in their region&#59; advise on the mode in which each action will be performed in the regions&#44; thereby ensuring maximum scientific rigour&#59; review the results obtained in the area&#59; and propose and reach an agreement on future lines of research&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The following actions are proposed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Three multi-centre prevalence studies&#44; which will be carried out in accordance with the ethics requirements of the declarations of Helsinki for research with human beings&#44; the good epidemiological practice guidelines of the International Conference on Harmonisation and the existing standards in Spain&#44; and which will be approved by the relevant ethics committees&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8728;</span><p id="par0070" class="elsevierStylePara elsevierViewall">In patients in dialysis&#44; both haemodialysis and peritoneal dialysis&#44; with non-restrictive inclusion criteria&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8728;</span><p id="par0075" class="elsevierStylePara elsevierViewall">In renal transplant patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8728;</span><p id="par0080" class="elsevierStylePara elsevierViewall">In patients with stages 3&#8211;5 CKD predialysis&#59; in this case the study is proposed as a pilot&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0085" class="elsevierStylePara elsevierViewall">The protocols for the studies will be available on the website enabled for the project&#46; Access by and participation of any SEN member will require prior approval of the project by the scientific committee&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Study of the family tree among patients diagnosed with FD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">The degree of knowledge of FD among nephrologists will be quantified before and after the development of the plan through a brief survey&#59; in this way the training needs of all of them with respect to the disease will be detected&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">University courses focused on FD and clinical genetics&#44; and regional on-site training sessions&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">An evidence-based review with analysis of all available information on FD in the field of Nephrology&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">&#8226;</span><p id="par0110" class="elsevierStylePara elsevierViewall">A pharmacoeconomic study of the economic burden of FD for society&#44; the individual and the healthcare system&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Finally&#44; the results obtained from the projects and activities performed will be collected and a white paper on FD will be prepared that may serve as a basis for preparing recommendations for early diagnosis of the disease in Nephrology&#46;</p></li></ul></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Follow-up</span><p id="par0120" class="elsevierStylePara elsevierViewall">In the course of the project the different committees will analyse the progress of the activities and studies&#44; and propose actions to improve those activities that require it&#46; At least 3 annual meetings are planned for each committee&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methodology of the epidemiological studies</span><p id="par0125" class="elsevierStylePara elsevierViewall">In the prevalence studies and the analysis of the relatives of patients diagnosed with FD&#44; after obtaining informed consent from all participants&#44; a specific electronic case report form &#40;e-CRF&#41; will be filled in for each study&#59; all will be available for restricted use by the investigators on the project website &#40;<a id="intr0020" class="elsevierStyleInterRef" href="http://www.prefine.es/">www&#46;prefine&#46;es</a>&#41;&#46; The e-CRF will include sociodemographic variables&#44; clinical disease events&#44; any complications or impairment of organs or systems that the patient may have and the dates on which the patient started to have symptoms suggestive of FD&#46; As these are epidemiological projects of prevalence in an at-risk population&#44; the aim is to screen as many patients as possible&#46; It is estimated that up to 10&#44;000 dialysis patients and 3000 transplant patients will be reached&#46; The number of CKD patients in the study has not been estimated as this is a pilot study&#46; Patient selection will be performed by means of consecutive sampling of patients who visit Nephrology outpatient clinics or are cared for at dialysis centres&#46; Patients of both sexes who meet the inclusion criteria for each study will be accepted&#44; without any age limit&#46; The dialysis study protocol has been approved by the Hospital Cl&#237;nic de Barcelona Ethics Committee&#44; and the transplant study protocol has been approved by Hospital de Bellvitge in L&#8217;Hospitalet de Llobregat &#40;Barcelona&#41;&#46; The CKD protocol is pending evaluation by the Basque Country IEC&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">All patients selected to participate will undergo a dried blood spot analysis&#59; male patients will undergo determination of their &#945;-galactosidase A enzyme activity&#44; and when this is below normal limits&#44; they will undergo a genetic study of the <span class="elsevierStyleItalic">GLA</span> gene&#59; women will undergo a genetic study regardless of their enzyme activity result&#46; All patients will undergo determination of their lyso-Gb3 value&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">A blood sample will be drawn from consenting patients and stored in the RedinRen biobank&#46; The sample will allow future research to be conducted in these populations&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Patients with a positive result for FD will be evaluated according to routine clinical practice at each site or will be referred to specialised sites with experience in management of the disease&#44; at the discretion of each investigator&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The SPSS statistical programme will be used for data analysis&#46; Descriptive statistical analysis of the variables will be performed&#46; A statistical significance level of 0&#46;05 will be used&#46; Preliminary statistical techniques will be used when performing hypothesis-verifying tests to ensure that statistical assumptions are met&#46; In the event that the established assumptions are not met&#44; equivalence tests without these limitations&#44; such as non-parametric tests&#44; will be used&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0150" class="elsevierStylePara elsevierViewall">The PrEFiNE project is the first comprehensive plan to improve knowledge of a rare disease in the field of a medical speciality&#46; It may serve as a pilot project to improve knowledge of rare diseases in target specialities&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Our hypothesis is that the range of activities aimed at all nephrologists will allow knowledge and recognition of FD to be improved and recommendations that facilitate management of these patients to be established&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Therefore&#44; it is hoped that this project will lead to a shift in the current paradigm in diagnosis of the disease such that time to diagnosis decreases and the long-term complications that these patients have may be reduced&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The results obtained will be very useful as they will allow comparison between the results for the different stages of CKD and subsequently comparison between these results and results obtained in future studies&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">However&#44; to achieve the proposed objectives&#44; this project requires the participation of the majority of Nephrology Departments&#44; which will be involved in both the training activities and the proposed lines of research&#46; The data generated during the project will follow the data use standards of the SEN and will be transferred to the SEN once all proposed objectives have been met&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Authorship standards will be established by the scientific committee of the project&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">We would like this study to be considered to be a common enterprise of the nephrologists of the SEN&#46; It is also our intention that this article which lays out the activities to be performed stimulates collaboration to achieve the desired objective&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres767384"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Discussion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec768534"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres767383"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Justificaci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Discusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec768535"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methodology"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "General design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Follow-up"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Methodology of the epidemiological studies"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-03-29"
    "fechaAceptado" => "2016-03-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec768534"
          "palabras" => array:5 [
            0 => "PrEFiNE Project"
            1 => "Fabry disease"
            2 => "Chronic kidney disease"
            3 => "Dialysis"
            4 => "Kidney transplant"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec768535"
          "palabras" => array:5 [
            0 => "Proyecto PrEFiNE"
            1 => "Enfermedad de Fabry"
            2 => "Enfermedad renal cr&#243;nica"
            3 => "Di&#225;lisis"
            4 => "Trasplante renal"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Renal failure is one of the main causes of death in patients with Fabry disease &#40;FD&#41;&#46; Due to the low prevalence of FD&#44; delayed diagnosis and misdiagnosis&#44; often the correct diagnosis is made when organ damage is already present&#46; Early recognition of the disease would allow the prevention of severe complications and the premature death of patients with FD&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present here the PrEFiNE project&#44; which includes a wide spectrum of activities with the aim of improve knowledge and diagnosis of FD&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The project is sponsored by Shire Iberia &#40;<a class="elsevierStyleInterRef" id="intr0010" href="http://shireiberica.com/">http&#58;&#47;&#47;shireiberica&#46;com&#47;</a>&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">From January 2016 to the end of 2017 several activities will be carried out&#44; starting with a survey to evaluate current FD knowledge among nephrologists&#59; in addition some studies to assess prevalence of this disease will be performed&#46; One study will include patients receiving dialysis&#44; another study will cover kidney transplant patients&#44; and a pilot study in chronic kidney disease in stage 3&#8211;5 predialysis&#46; Also planned is a pharmacoeconomic study to focus on burden of FD&#46; At the same time medical education activities will be conducted both on line and on site&#46; Plan for dissemination will include medical publications and diffusion to media&#46; PrEFiNE Project will finish with the publication of a compilation book on FD in Nephrology including all planned activities and proposing recommendations based on results and detected unmet needs&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PrEfiNE Plan will be coordinated by severa scientific committees&#44; one at national level and 10 other regionals committees&#44; that will be responsible to ensure the maximum scientific quality of proposed activities&#46; An advisory board will supervise the project&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">PrEfiNE project will evaluate an action plan focused on improving FD knowledge to make necessary recommendations for an early recognition of the disease&#46; In addition will generate a plan to improve previously undetected needs&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Discussion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Justificaci&#243;n</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La enfermedad renal es una de las principales causas de muerte entre los pacientes con enfermedad de Fabry &#40;EF&#41;&#46; Al tratarse de una enfermedad de baja prevalencia&#44; se realizan con frecuencia diagn&#243;sticos err&#243;neos y retrasados&#44; que a menudo se dan cuando ya se ha producido da&#241;o org&#225;nico&#46; El reconocimiento temprano de la enfermedad permitir&#237;a evitar las complicaciones graves y la muerte prematura en estos pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Presentamos en este art&#237;culo un resumen del plan PrEFiNE&#44; que incluye un abanico amplio de actividades con el objetivo de mejorar el conocimiento y reconocimiento de la EF entre los nefr&#243;logos&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Este proyecto est&#225; patrocinado por Shire Ib&#233;rica &#40;<a class="elsevierStyleInterRef" id="intr0015" href="http://shireiberica.com/">http&#58;&#47;&#47;shireiberica&#46;com&#47;</a>&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">M&#233;todos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Desde enero de 2016 y hasta finales del 2017 se iniciar&#225;n distintas actividades&#44; comenzando por una evaluaci&#243;n del grado de conocimiento que existe actualmente sobre la EF&#46; Se incluyen 3 estudios de prevalencia de la EF&#44; que abarcan el espectro de los pacientes con enfermedad renal cr&#243;nica &#40;pacientes en di&#225;lisis&#44; pacientes trasplantados renales y un estudio piloto en pacientes con enfermedad renal cr&#243;nica en estadio 3&#8211;5 predi&#225;lisis&#41; y un estudio farmacoecon&#243;mico&#44; centrado en el impacto de la carga de la enfermedad&#46; Paralelamente&#44; se realizar&#225;n actividades formativas tanto presenciales como <span class="elsevierStyleItalic">on line</span>&#44; y un amplio plan de comunicaci&#243;n mediante publicaciones y difusi&#243;n a medios&#46; El proyecto culminar&#225; con la publicaci&#243;n de un libro blanco de la EF en Nefrolog&#237;a&#44; que recoja el resultado de todas las actividades y que proponga recomendaciones en respuesta a los resultados y a las necesidades detectadas&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">El plan PrEFiNE estar&#225; coordinado por distintos comit&#233;s cient&#237;ficos&#44; uno nacional y 10 regionales que garantizar&#225;n el desarrollo de las acciones con el m&#225;ximo rigor cient&#237;fico y ser&#225; supervisado por un comit&#233; asesor&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discusi&#243;n</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El plan PrEFiNE nos permitir&#225; evaluar la utilidad de un proyecto dirigido a mejorar el conocimiento de una enfermedad minoritaria como la EF a nivel nacional&#44; y a partir del cual se podr&#225;n establecer las recomendaciones necesarias para mejorar su reconocimiento&#44; adem&#225;s de planes enfocados a mejorar las necesidades no cubiertas detectadas durante su desarrollo&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Justificaci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Discusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; del Pino MD&#44; Ortiz A&#44; Torra R&#44; Hernandez D&#46; Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a&#46; Nefrolog&#237;a&#46; 2016&#59;36&#58;376&#8211;380&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2638
            "Ancho" => 3167
            "Tamanyo" => 386114
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Actions&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of lysosomal storage disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;J&#46; Meikle"
                            1 => "J&#46;J&#46; Hopwood"
                            2 => "A&#46;E&#46; Clague"
                            3 => "W&#46;F&#46; Carey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1999"
                        "volumen" => "281"
                        "paginaInicial" => "249"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9918480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease&#44; an under-recognized multisystemic disorder&#58; expert recommendations for diagnosis&#46; management&#44; and enzyme replacement therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Desnick"
                            1 => "R&#46; Brady"
                            2 => "J&#46; Barranger"
                            3 => "A&#46;J&#46; Collins"
                            4 => "D&#46;P&#46; Germain"
                            5 => "M&#46; Goldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2003"
                        "volumen" => "138"
                        "paginaInicial" => "338"
                        "paginaFinal" => "346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12585833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The frequency of lysosomal storage diseases in The Netherlands"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;J&#46; Poorthuis"
                            1 => "R&#46;A&#46; Wevers"
                            2 => "W&#46;J&#46; Kleijer"
                            3 => "J&#46;E&#46; Groener"
                            4 => "J&#46;G&#46; de Jong"
                            5 => "S&#46; van Weely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genet"
                        "fecha" => "1999"
                        "volumen" => "105"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10480370"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The birth prevalence of lysosomal storage disorders in the Czech Republic&#58; comparison with data in different populations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Poupetov&#225;"
                            1 => "J&#46; Ledvinov&#225;"
                            2 => "L&#46; Bern&#225;"
                            3 => "L&#46; Dvor&#225;kov&#225;"
                            4 => "V&#46; Kozich"
                            5 => "M&#46; Elleder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10545-010-9093-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Inherit Metab Dis"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "387"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20490927"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatal screening f or lysosomal storage disorders&#58; feasibility and incidence from a nationwide study in Austria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;P&#46; Mechtler"
                            1 => "S&#46; Stary"
                            2 => "T&#46;F&#46; Metz"
                            3 => "V&#46;R&#46; de Jes&#250;s"
                            4 => "S&#46; Greber-Platzer"
                            5 => "A&#46; Pollak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(11)61266-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2012"
                        "volumen" => "379"
                        "paginaInicial" => "335"
                        "paginaFinal" => "341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22133539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;Epub 2006 April 28&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High incidence of later-onset Fabry disease revealed by newborn screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Spada"
                            1 => "S&#46; Pagliardini"
                            2 => "M&#46; Yasuda"
                            3 => "T&#46; Tukel"
                            4 => "G&#46; Thiagarajan"
                            5 => "H&#46; Sakuraba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/504601"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2006"
                        "volumen" => "79"
                        "paginaInicial" => "31"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16773563"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for Fabry disease in high-risk populations&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;E&#46; Linthorst"
                            1 => "M&#46;G&#46; Bouwman"
                            2 => "F&#46;A&#46; Wijburg"
                            3 => "J&#46;M&#46; Aerts"
                            4 => "B&#46;J&#46; Poorthuis"
                            5 => "C&#46;E&#46; Hollak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jmg.2009.072116"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2010"
                        "volumen" => "47"
                        "paginaInicial" => "217"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797197"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anderson-Fabry disease&#58; clinical manifestations and impact of disease in a cohort of 98 hemizygous males"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;D&#46; MacDermot"
                            1 => "A&#46; Holmes"
                            2 => "A&#46;H&#46; Miners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "750"
                        "paginaFinal" => "760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11694547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anderson-Fabry disease&#58; clinical manifestations and impact of disease in a cohort of 60 obligate carrier females"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;D&#46; MacDermot"
                            1 => "A&#46; Holmes"
                            2 => "A&#46;H&#46; Miners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "769"
                        "paginaFinal" => "775"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11732485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease&#58; guidelines for the evaluation and management of multi-organ system involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Eng"
                            1 => "D&#46;P&#46; Germain"
                            2 => "M&#46; Banikazemi"
                            3 => "D&#46;G&#46; Warnock"
                            4 => "C&#46; Wanner"
                            5 => "R&#46;J&#46; Hopkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.109701.gim.0000237866.70357.c6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Med"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "539"
                        "paginaFinal" => "548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16980809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal pathological changes in Fabry disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Sessa"
                            1 => "M&#46; Meroni"
                            2 => "G&#46; Battini"
                            3 => "A&#46; Maglio"
                            4 => "P&#46;L&#46; Brambilla"
                            5 => "M&#46; Bertella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Inherit Metab Dis"
                        "fecha" => "2001"
                        "volumen" => "24"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "66"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11758681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease defined&#58; baseline clinical manifestations of 366 patients in the Fabry Outcome Survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mehta"
                            1 => "R&#46; Ricci"
                            2 => "U&#46; Widmer"
                            3 => "F&#46; Dehout"
                            4 => "A&#46; Garcia de Lorenzo"
                            5 => "C&#46; Kampmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2362.2004.01309.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Invest"
                        "fecha" => "2004"
                        "volumen" => "34"
                        "paginaInicial" => "236"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15025684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "Mehta&#46; Hosp Med&#46; 2002&#59;63&#58;347&#8211;350"
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Beck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Fabry disease&#58; perspectives from 5 years of FOS"
                        "paginaInicial" => "4"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry nephropathy&#58; a review &#8211; how can we optimize the management of Fabry nephropathy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Waldek"
                            1 => "S&#46; Feriozzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-15-72"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24886109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003600000004/v1_201612030031/S201325141630089X/v1_201612030031/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "60960"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Special articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003600000004/v1_201612030031/S201325141630089X/v1_201612030031/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630089X?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Special article
PrEFiNe Plan: Strategic plan for Fabry's diseases in Nephrology
Plan PrEFiNE: Plan estratégico para la enfermedad de Fabry en Nefrología
M.D. del Pinoa,
Corresponding author
, A. Ortizb, R. Torrac, D. Hernandezd
a Servicio de Nefrología, Hospital Torrecárdenas, Almería, Spain
b Servicio de Nefrología, Fundación Jimenez Díaz, Madrid, Spain
c Servició de Nefrología, Fundación Puigvert, Barcelona, Spain
d Servicio de Nefrología, Hospital Regional, Málaga, Spain
Read
8002
Times
was read the article
2234
Total PDF
5768
Total HTML
Share statistics
 array:25 [
  "pii" => "S201325141630089X"
  "issn" => "20132514"
  "doi" => "10.1016/j.nefroe.2016.10.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-07-01"
  "aid" => "180"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:376-80"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3898
    "formatos" => array:3 [
      "EPUB" => 316
      "HTML" => 2964
      "PDF" => 618
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0211699516300121"
      "issn" => "02116995"
      "doi" => "10.1016/j.nefro.2016.03.009"
      "estado" => "S300"
      "fechaPublicacion" => "2016-07-01"
      "aid" => "180"
      "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
      "documento" => "article"
      "crossmark" => 0
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2016;36:376-80"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7656
        "formatos" => array:3 [
          "EPUB" => 363
          "HTML" => 6131
          "PDF" => 1162
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo especial</span>"
        "titulo" => "Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "376"
            "paginaFinal" => "380"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "PrEFiNe Plan&#58; Strategic plan for Fabry diseases in Nephrology"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2638
                "Ancho" => 3167
                "Tamanyo" => 411469
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Acciones&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "M&#46;D&#46; del Pino, A&#46; Ortiz, R&#46; Torra, D&#46; Hernandez"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "M&#46;D&#46;"
                "apellidos" => "del Pino"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Ortiz"
              ]
              2 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Torra"
              ]
              3 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Hernandez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S201325141630089X"
          "doi" => "10.1016/j.nefroe.2016.10.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630089X?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300121?idApp=UINPBA000064"
      "url" => "/02116995/0000003600000004/v2_201611160150/S0211699516300121/v2_201611160150/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2013251416300888"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.10.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "505"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:381-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4475
      "formatos" => array:3 [
        "EPUB" => 315
        "HTML" => 3002
        "PDF" => 1158
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "COSMOS Project&#58; Haemodialysis scenario in Europe"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "381"
          "paginaFinal" => "388"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Proyecto COSMOS&#58; escenario de la hemodi&#225;lisis en Europa"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jorge B&#46; Cannata-And&#237;a, Jos&#233; Luis Fern&#225;ndez-Mart&#237;n"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Jorge B&#46;"
              "apellidos" => "Cannata-And&#237;a"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Fern&#225;ndez-Mart&#237;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021169951630011X"
        "doi" => "10.1016/j.nefro.2016.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169951630011X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300888?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000004/v1_201612030031/S2013251416300888/v1_201612030031/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2013251416300700"
    "issn" => "20132514"
    "doi" => "10.1016/j.nefroe.2016.08.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-07-01"
    "aid" => "175"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "ssu"
    "cita" => "Nefrologia &#40;English Version&#41;. 2016;36:368-75"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7564
      "formatos" => array:3 [
        "EPUB" => 371
        "HTML" => 6254
        "PDF" => 939
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Bone mineral disorder in chronic kidney disease&#58; Klotho and FGF23&#59; cardiovascular implications"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "368"
          "paginaFinal" => "375"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Enfermedad &#243;seo mineral relacionada con la enfermedad renal cr&#243;nica&#58; Klotho y FGF23&#59; implicaciones cardiovasculares"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1764
              "Ancho" => 2332
              "Tamanyo" => 295812
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Diagram of BMD-CKD abnormalities and involvement in vascular calcification&#46; CVD&#58; cardiovascular disease&#59; uP&#58; urine phosphorus&#59; pP&#58; plasma phosphorus&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Laura Salanova Villanueva, Carmen S&#225;nchez Gonz&#225;lez, Jos&#233; Antonio S&#225;nchez Tomero, Abelardo Aguilera, Esther Ortega Junco"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Salanova Villanueva"
            ]
            1 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "S&#225;nchez Gonz&#225;lez"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Antonio"
              "apellidos" => "S&#225;nchez Tomero"
            ]
            3 => array:2 [
              "nombre" => "Abelardo"
              "apellidos" => "Aguilera"
            ]
            4 => array:2 [
              "nombre" => "Esther"
              "apellidos" => "Ortega Junco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0211699516300078"
        "doi" => "10.1016/j.nefro.2016.01.011"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300078?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416300700?idApp=UINPBA000064"
    "url" => "/20132514/0000003600000004/v1_201612030031/S2013251416300700/v1_201612030031/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
    "titulo" => "PrEFiNe Plan&#58; Strategic plan for Fabry&#39;s diseases in Nephrology"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "376"
        "paginaFinal" => "380"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;D&#46; del Pino, A&#46; Ortiz, R&#46; Torra, D&#46; Hernandez"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "M&#46;D&#46;"
            "apellidos" => "del Pino"
            "email" => array:2 [
              0 => "mdpinoypino&#64;gmail&#46;com"
              1 => "http&#58;&#47;&#47;www&#46;prefine&#46;es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Ortiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Torra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Hernandez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Torrec&#225;rdenas&#44; Almer&#237;a&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Fundaci&#243;n Jimenez D&#237;az&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servici&#243; de Nefrolog&#237;a&#44; Fundaci&#243;n Puigvert&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital Regional&#44; M&#225;laga&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2638
            "Ancho" => 3167
            "Tamanyo" => 386114
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Actions&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Fabry&#39;s disease &#40;FD&#41; is a lysosomal disease that is characterised by a deficiency in &#945;-galactosidase A&#44; an enzyme that causes glycosphingolipids&#44; mainly globotriaosylceramide &#40;Gb3&#41;&#44; to be deposited in the vascular endothelium and other tissues&#46; It is a progressive disease that causes manifestations in the kidneys&#44; heart&#44; nervous system&#44; skin&#44; eyes and other systems&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is considered to be a rare disease&#44; as it affects 1 in 40&#44;000&#8211;238&#44;000 males&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; studies conducted using neonatal screening have observed a greater incidence&#44; of 1&#47;3100 to 1&#47;4100 live births for late-onset forms and 1&#47;37&#44;000 for classic phenotypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">5&#44;6</span></a> Obviously&#44; its frequency is greater in high-risk populations such as the population affected by chronic kidney disease &#40;CKD&#41; that requires dialysis or the population suffering from by left ventricular hypertrophy or stroke&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">7</span></a> Life expectancy is normally shortened by 20 years in men<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a> and 15 years in women&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a> One of the main causes of death in patients with FD is renal failure and it occurs very early&#44; in the fourth or fifth decade of life&#44; particularly in males&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">One analysis of patients with FD determined that more than 25&#37; had been diagnosed incorrectly initially<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> and that their diagnosis took an average of 12 years to confirm&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> Diagnosis tends to be delayed by at least 3 years&#44; but it often takes 20 years after the onset of signs and symptoms&#46; Some patients have even experienced delays of more than 50 years&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> Patients with FD and already impaired renal function have a more unfavourable prognosis than those without it&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In clinical practice there is no unanimous agreement for including FD as part of the differential diagnosis of patients with CKD in any stage&#46; This makes it difficult to diagnose the disease early&#44; identify at-risk family relatives and prevent other secondary and potentially deadly complications of the disease&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As generally occurs with rare diseases&#44; part of the problem may lie in limited awareness of the disease such that a diagnosis of FD may not be considered as part of the diagnostic algorithm for patients with CKD&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The PrEFiNE plan was created with the aim of improving knowledge and recognition of FD among all nephrologists&#44; which would allow an early diagnosis of the disease and an early approach to patients who have it&#46; The aims of this plan are many and range from evaluating current knowledge of FD and establishing its prevalence in patients with CKD &#40;dialysis&#44; transplant and stage 3&#8211;5 CKD predialysis&#41;&#59; evaluating the impact of FD from a healthcare-related&#44; sociological and economic point of view&#59; improving knowledge of FD through specific training in the disease&#59; detecting potential unmet needs in the approach to FD&#59; and&#44; finally&#44; developing a prioritised action plan to improve the needs detected and reduce the repercussions of the disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Therefore&#44; this multi-centre project&#44; encompassing all of Spain&#44; is being proposed through a broad training and information campaign&#44; with continuing education and enhancement of different research studies&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The intention of this article is to spread information on the design of this project and some of its activities to offer it as a platform that facilitates and stimulates research on and knowledge of FD among Spanish nephrologists&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methodology</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">General design</span><p id="par0045" class="elsevierStylePara elsevierViewall">The project will have an advisory committee headed by the chairperson of the Spanish Society of Nephrology &#40;SEN&#41; who will be in charge of driving&#44; promoting and reviewing the project&#59; advising on the proposed aims&#59; and involving all participants effectively&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A scientific committee will validate the general approach of the project and the actions and studies to be carried out&#59; advise on the mode in which each action will be performed&#44; thereby ensuring maximum scientific rigour&#59; select and produce required training materials &#40;in person and online&#41;&#44; review the results obtained&#59; and propose and reach an agreement on future lines of research&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Regional committees will coordinate and execute the training activities required to improve knowledge of FD in their region&#59; advise on the mode in which each action will be performed in the regions&#44; thereby ensuring maximum scientific rigour&#59; review the results obtained in the area&#59; and propose and reach an agreement on future lines of research&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The following actions are proposed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Three multi-centre prevalence studies&#44; which will be carried out in accordance with the ethics requirements of the declarations of Helsinki for research with human beings&#44; the good epidemiological practice guidelines of the International Conference on Harmonisation and the existing standards in Spain&#44; and which will be approved by the relevant ethics committees&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8728;</span><p id="par0070" class="elsevierStylePara elsevierViewall">In patients in dialysis&#44; both haemodialysis and peritoneal dialysis&#44; with non-restrictive inclusion criteria&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8728;</span><p id="par0075" class="elsevierStylePara elsevierViewall">In renal transplant patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8728;</span><p id="par0080" class="elsevierStylePara elsevierViewall">In patients with stages 3&#8211;5 CKD predialysis&#59; in this case the study is proposed as a pilot&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0085" class="elsevierStylePara elsevierViewall">The protocols for the studies will be available on the website enabled for the project&#46; Access by and participation of any SEN member will require prior approval of the project by the scientific committee&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0090" class="elsevierStylePara elsevierViewall">Study of the family tree among patients diagnosed with FD&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">&#8226;</span><p id="par0095" class="elsevierStylePara elsevierViewall">The degree of knowledge of FD among nephrologists will be quantified before and after the development of the plan through a brief survey&#59; in this way the training needs of all of them with respect to the disease will be detected&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">&#8226;</span><p id="par0100" class="elsevierStylePara elsevierViewall">University courses focused on FD and clinical genetics&#44; and regional on-site training sessions&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">&#8226;</span><p id="par0105" class="elsevierStylePara elsevierViewall">An evidence-based review with analysis of all available information on FD in the field of Nephrology&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">&#8226;</span><p id="par0110" class="elsevierStylePara elsevierViewall">A pharmacoeconomic study of the economic burden of FD for society&#44; the individual and the healthcare system&#46;</p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">&#8226;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Finally&#44; the results obtained from the projects and activities performed will be collected and a white paper on FD will be prepared that may serve as a basis for preparing recommendations for early diagnosis of the disease in Nephrology&#46;</p></li></ul></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Follow-up</span><p id="par0120" class="elsevierStylePara elsevierViewall">In the course of the project the different committees will analyse the progress of the activities and studies&#44; and propose actions to improve those activities that require it&#46; At least 3 annual meetings are planned for each committee&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methodology of the epidemiological studies</span><p id="par0125" class="elsevierStylePara elsevierViewall">In the prevalence studies and the analysis of the relatives of patients diagnosed with FD&#44; after obtaining informed consent from all participants&#44; a specific electronic case report form &#40;e-CRF&#41; will be filled in for each study&#59; all will be available for restricted use by the investigators on the project website &#40;<a id="intr0020" class="elsevierStyleInterRef" href="http://www.prefine.es/">www&#46;prefine&#46;es</a>&#41;&#46; The e-CRF will include sociodemographic variables&#44; clinical disease events&#44; any complications or impairment of organs or systems that the patient may have and the dates on which the patient started to have symptoms suggestive of FD&#46; As these are epidemiological projects of prevalence in an at-risk population&#44; the aim is to screen as many patients as possible&#46; It is estimated that up to 10&#44;000 dialysis patients and 3000 transplant patients will be reached&#46; The number of CKD patients in the study has not been estimated as this is a pilot study&#46; Patient selection will be performed by means of consecutive sampling of patients who visit Nephrology outpatient clinics or are cared for at dialysis centres&#46; Patients of both sexes who meet the inclusion criteria for each study will be accepted&#44; without any age limit&#46; The dialysis study protocol has been approved by the Hospital Cl&#237;nic de Barcelona Ethics Committee&#44; and the transplant study protocol has been approved by Hospital de Bellvitge in L&#8217;Hospitalet de Llobregat &#40;Barcelona&#41;&#46; The CKD protocol is pending evaluation by the Basque Country IEC&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">All patients selected to participate will undergo a dried blood spot analysis&#59; male patients will undergo determination of their &#945;-galactosidase A enzyme activity&#44; and when this is below normal limits&#44; they will undergo a genetic study of the <span class="elsevierStyleItalic">GLA</span> gene&#59; women will undergo a genetic study regardless of their enzyme activity result&#46; All patients will undergo determination of their lyso-Gb3 value&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">A blood sample will be drawn from consenting patients and stored in the RedinRen biobank&#46; The sample will allow future research to be conducted in these populations&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Patients with a positive result for FD will be evaluated according to routine clinical practice at each site or will be referred to specialised sites with experience in management of the disease&#44; at the discretion of each investigator&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The SPSS statistical programme will be used for data analysis&#46; Descriptive statistical analysis of the variables will be performed&#46; A statistical significance level of 0&#46;05 will be used&#46; Preliminary statistical techniques will be used when performing hypothesis-verifying tests to ensure that statistical assumptions are met&#46; In the event that the established assumptions are not met&#44; equivalence tests without these limitations&#44; such as non-parametric tests&#44; will be used&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0150" class="elsevierStylePara elsevierViewall">The PrEFiNE project is the first comprehensive plan to improve knowledge of a rare disease in the field of a medical speciality&#46; It may serve as a pilot project to improve knowledge of rare diseases in target specialities&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Our hypothesis is that the range of activities aimed at all nephrologists will allow knowledge and recognition of FD to be improved and recommendations that facilitate management of these patients to be established&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Therefore&#44; it is hoped that this project will lead to a shift in the current paradigm in diagnosis of the disease such that time to diagnosis decreases and the long-term complications that these patients have may be reduced&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The results obtained will be very useful as they will allow comparison between the results for the different stages of CKD and subsequently comparison between these results and results obtained in future studies&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">However&#44; to achieve the proposed objectives&#44; this project requires the participation of the majority of Nephrology Departments&#44; which will be involved in both the training activities and the proposed lines of research&#46; The data generated during the project will follow the data use standards of the SEN and will be transferred to the SEN once all proposed objectives have been met&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Authorship standards will be established by the scientific committee of the project&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">We would like this study to be considered to be a common enterprise of the nephrologists of the SEN&#46; It is also our intention that this article which lays out the activities to be performed stimulates collaboration to achieve the desired objective&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres767384"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Methods"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Discussion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec768534"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres767383"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Justificaci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Objetivo"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "M&#233;todos"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Discusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec768535"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methodology"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "General design"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Follow-up"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Methodology of the epidemiological studies"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-03-29"
    "fechaAceptado" => "2016-03-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec768534"
          "palabras" => array:5 [
            0 => "PrEFiNE Project"
            1 => "Fabry disease"
            2 => "Chronic kidney disease"
            3 => "Dialysis"
            4 => "Kidney transplant"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec768535"
          "palabras" => array:5 [
            0 => "Proyecto PrEFiNE"
            1 => "Enfermedad de Fabry"
            2 => "Enfermedad renal cr&#243;nica"
            3 => "Di&#225;lisis"
            4 => "Trasplante renal"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Renal failure is one of the main causes of death in patients with Fabry disease &#40;FD&#41;&#46; Due to the low prevalence of FD&#44; delayed diagnosis and misdiagnosis&#44; often the correct diagnosis is made when organ damage is already present&#46; Early recognition of the disease would allow the prevention of severe complications and the premature death of patients with FD&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present here the PrEFiNE project&#44; which includes a wide spectrum of activities with the aim of improve knowledge and diagnosis of FD&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The project is sponsored by Shire Iberia &#40;<a class="elsevierStyleInterRef" id="intr0010" href="http://shireiberica.com/">http&#58;&#47;&#47;shireiberica&#46;com&#47;</a>&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">From January 2016 to the end of 2017 several activities will be carried out&#44; starting with a survey to evaluate current FD knowledge among nephrologists&#59; in addition some studies to assess prevalence of this disease will be performed&#46; One study will include patients receiving dialysis&#44; another study will cover kidney transplant patients&#44; and a pilot study in chronic kidney disease in stage 3&#8211;5 predialysis&#46; Also planned is a pharmacoeconomic study to focus on burden of FD&#46; At the same time medical education activities will be conducted both on line and on site&#46; Plan for dissemination will include medical publications and diffusion to media&#46; PrEFiNE Project will finish with the publication of a compilation book on FD in Nephrology including all planned activities and proposing recommendations based on results and detected unmet needs&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PrEfiNE Plan will be coordinated by severa scientific committees&#44; one at national level and 10 other regionals committees&#44; that will be responsible to ensure the maximum scientific quality of proposed activities&#46; An advisory board will supervise the project&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">PrEfiNE project will evaluate an action plan focused on improving FD knowledge to make necessary recommendations for an early recognition of the disease&#46; In addition will generate a plan to improve previously undetected needs&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Discussion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Justificaci&#243;n</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La enfermedad renal es una de las principales causas de muerte entre los pacientes con enfermedad de Fabry &#40;EF&#41;&#46; Al tratarse de una enfermedad de baja prevalencia&#44; se realizan con frecuencia diagn&#243;sticos err&#243;neos y retrasados&#44; que a menudo se dan cuando ya se ha producido da&#241;o org&#225;nico&#46; El reconocimiento temprano de la enfermedad permitir&#237;a evitar las complicaciones graves y la muerte prematura en estos pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivo</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Presentamos en este art&#237;culo un resumen del plan PrEFiNE&#44; que incluye un abanico amplio de actividades con el objetivo de mejorar el conocimiento y reconocimiento de la EF entre los nefr&#243;logos&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Este proyecto est&#225; patrocinado por Shire Ib&#233;rica &#40;<a class="elsevierStyleInterRef" id="intr0015" href="http://shireiberica.com/">http&#58;&#47;&#47;shireiberica&#46;com&#47;</a>&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">M&#233;todos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Desde enero de 2016 y hasta finales del 2017 se iniciar&#225;n distintas actividades&#44; comenzando por una evaluaci&#243;n del grado de conocimiento que existe actualmente sobre la EF&#46; Se incluyen 3 estudios de prevalencia de la EF&#44; que abarcan el espectro de los pacientes con enfermedad renal cr&#243;nica &#40;pacientes en di&#225;lisis&#44; pacientes trasplantados renales y un estudio piloto en pacientes con enfermedad renal cr&#243;nica en estadio 3&#8211;5 predi&#225;lisis&#41; y un estudio farmacoecon&#243;mico&#44; centrado en el impacto de la carga de la enfermedad&#46; Paralelamente&#44; se realizar&#225;n actividades formativas tanto presenciales como <span class="elsevierStyleItalic">on line</span>&#44; y un amplio plan de comunicaci&#243;n mediante publicaciones y difusi&#243;n a medios&#46; El proyecto culminar&#225; con la publicaci&#243;n de un libro blanco de la EF en Nefrolog&#237;a&#44; que recoja el resultado de todas las actividades y que proponga recomendaciones en respuesta a los resultados y a las necesidades detectadas&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">El plan PrEFiNE estar&#225; coordinado por distintos comit&#233;s cient&#237;ficos&#44; uno nacional y 10 regionales que garantizar&#225;n el desarrollo de las acciones con el m&#225;ximo rigor cient&#237;fico y ser&#225; supervisado por un comit&#233; asesor&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discusi&#243;n</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">El plan PrEFiNE nos permitir&#225; evaluar la utilidad de un proyecto dirigido a mejorar el conocimiento de una enfermedad minoritaria como la EF a nivel nacional&#44; y a partir del cual se podr&#225;n establecer las recomendaciones necesarias para mejorar su reconocimiento&#44; adem&#225;s de planes enfocados a mejorar las necesidades no cubiertas detectadas durante su desarrollo&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Justificaci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Discusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; del Pino MD&#44; Ortiz A&#44; Torra R&#44; Hernandez D&#46; Plan PrEFiNE&#58; Plan estrat&#233;gico para la enfermedad de Fabry en Nefrolog&#237;a&#46; Nefrolog&#237;a&#46; 2016&#59;36&#58;376&#8211;380&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2638
            "Ancho" => 3167
            "Tamanyo" => 386114
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Actions&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:14 [
            0 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of lysosomal storage disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;J&#46; Meikle"
                            1 => "J&#46;J&#46; Hopwood"
                            2 => "A&#46;E&#46; Clague"
                            3 => "W&#46;F&#46; Carey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1999"
                        "volumen" => "281"
                        "paginaInicial" => "249"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9918480"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease&#44; an under-recognized multisystemic disorder&#58; expert recommendations for diagnosis&#46; management&#44; and enzyme replacement therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Desnick"
                            1 => "R&#46; Brady"
                            2 => "J&#46; Barranger"
                            3 => "A&#46;J&#46; Collins"
                            4 => "D&#46;P&#46; Germain"
                            5 => "M&#46; Goldman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2003"
                        "volumen" => "138"
                        "paginaInicial" => "338"
                        "paginaFinal" => "346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12585833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The frequency of lysosomal storage diseases in The Netherlands"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;J&#46; Poorthuis"
                            1 => "R&#46;A&#46; Wevers"
                            2 => "W&#46;J&#46; Kleijer"
                            3 => "J&#46;E&#46; Groener"
                            4 => "J&#46;G&#46; de Jong"
                            5 => "S&#46; van Weely"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genet"
                        "fecha" => "1999"
                        "volumen" => "105"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10480370"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The birth prevalence of lysosomal storage disorders in the Czech Republic&#58; comparison with data in different populations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Poupetov&#225;"
                            1 => "J&#46; Ledvinov&#225;"
                            2 => "L&#46; Bern&#225;"
                            3 => "L&#46; Dvor&#225;kov&#225;"
                            4 => "V&#46; Kozich"
                            5 => "M&#46; Elleder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10545-010-9093-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Inherit Metab Dis"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "387"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20490927"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatal screening f or lysosomal storage disorders&#58; feasibility and incidence from a nationwide study in Austria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;P&#46; Mechtler"
                            1 => "S&#46; Stary"
                            2 => "T&#46;F&#46; Metz"
                            3 => "V&#46;R&#46; de Jes&#250;s"
                            4 => "S&#46; Greber-Platzer"
                            5 => "A&#46; Pollak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(11)61266-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2012"
                        "volumen" => "379"
                        "paginaInicial" => "335"
                        "paginaFinal" => "341"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22133539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "&#91;Epub 2006 April 28&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High incidence of later-onset Fabry disease revealed by newborn screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Spada"
                            1 => "S&#46; Pagliardini"
                            2 => "M&#46; Yasuda"
                            3 => "T&#46; Tukel"
                            4 => "G&#46; Thiagarajan"
                            5 => "H&#46; Sakuraba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/504601"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2006"
                        "volumen" => "79"
                        "paginaInicial" => "31"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16773563"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for Fabry disease in high-risk populations&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;E&#46; Linthorst"
                            1 => "M&#46;G&#46; Bouwman"
                            2 => "F&#46;A&#46; Wijburg"
                            3 => "J&#46;M&#46; Aerts"
                            4 => "B&#46;J&#46; Poorthuis"
                            5 => "C&#46;E&#46; Hollak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jmg.2009.072116"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2010"
                        "volumen" => "47"
                        "paginaInicial" => "217"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797197"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anderson-Fabry disease&#58; clinical manifestations and impact of disease in a cohort of 98 hemizygous males"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;D&#46; MacDermot"
                            1 => "A&#46; Holmes"
                            2 => "A&#46;H&#46; Miners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "750"
                        "paginaFinal" => "760"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11694547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anderson-Fabry disease&#58; clinical manifestations and impact of disease in a cohort of 60 obligate carrier females"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;D&#46; MacDermot"
                            1 => "A&#46; Holmes"
                            2 => "A&#46;H&#46; Miners"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Genet"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "769"
                        "paginaFinal" => "775"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11732485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease&#58; guidelines for the evaluation and management of multi-organ system involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;M&#46; Eng"
                            1 => "D&#46;P&#46; Germain"
                            2 => "M&#46; Banikazemi"
                            3 => "D&#46;G&#46; Warnock"
                            4 => "C&#46; Wanner"
                            5 => "R&#46;J&#46; Hopkin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.109701.gim.0000237866.70357.c6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Med"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "539"
                        "paginaFinal" => "548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16980809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal pathological changes in Fabry disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Sessa"
                            1 => "M&#46; Meroni"
                            2 => "G&#46; Battini"
                            3 => "A&#46; Maglio"
                            4 => "P&#46;L&#46; Brambilla"
                            5 => "M&#46; Bertella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Inherit Metab Dis"
                        "fecha" => "2001"
                        "volumen" => "24"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "66"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11758681"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry disease defined&#58; baseline clinical manifestations of 366 patients in the Fabry Outcome Survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Mehta"
                            1 => "R&#46; Ricci"
                            2 => "U&#46; Widmer"
                            3 => "F&#46; Dehout"
                            4 => "A&#46; Garcia de Lorenzo"
                            5 => "C&#46; Kampmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2362.2004.01309.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Invest"
                        "fecha" => "2004"
                        "volumen" => "34"
                        "paginaInicial" => "236"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15025684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "Mehta&#46; Hosp Med&#46; 2002&#59;63&#58;347&#8211;350"
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Beck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Fabry disease&#58; perspectives from 5 years of FOS"
                        "paginaInicial" => "4"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fabry nephropathy&#58; a review &#8211; how can we optimize the management of Fabry nephropathy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Waldek"
                            1 => "S&#46; Feriozzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2369-15-72"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Nephrol"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "72"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24886109"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003600000004/v1_201612030031/S201325141630089X/v1_201612030031/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "60960"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Special articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003600000004/v1_201612030031/S201325141630089X/v1_201612030031/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630089X?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 2 6 8
2024 October 59 33 92
2024 September 39 18 57
2024 August 52 48 100
2024 July 36 24 60
2024 June 48 39 87
2024 May 57 33 90
2024 April 49 35 84
2024 March 37 25 62
2024 February 38 37 75
2024 January 37 21 58
2023 December 30 19 49
2023 November 38 28 66
2023 October 27 29 56
2023 September 27 22 49
2023 August 28 20 48
2023 July 33 19 52
2023 June 39 16 55
2023 May 46 29 75
2023 April 24 11 35
2023 March 51 21 72
2023 February 28 18 46
2023 January 31 23 54
2022 December 85 21 106
2022 November 54 19 73
2022 October 57 42 99
2022 September 44 24 68
2022 August 49 45 94
2022 July 48 42 90
2022 June 60 37 97
2022 May 62 33 95
2022 April 83 43 126
2022 March 103 31 134
2022 February 90 40 130
2022 January 75 33 108
2021 December 61 37 98
2021 November 66 36 102
2021 October 71 41 112
2021 September 36 28 64
2021 August 48 43 91
2021 July 82 26 108
2021 June 50 34 84
2021 May 48 56 104
2021 April 136 66 202
2021 March 49 55 104
2021 February 54 20 74
2021 January 36 22 58
2020 December 49 13 62
2020 November 50 12 62
2020 October 33 21 54
2020 September 31 20 51
2020 August 39 14 53
2020 July 41 24 65
2020 June 30 14 44
2020 May 37 12 49
2020 April 39 14 53
2020 March 36 19 55
2020 February 31 18 49
2020 January 37 23 60
2019 December 49 18 67
2019 November 38 23 61
2019 October 46 31 77
2019 September 32 16 48
2019 August 29 14 43
2019 July 30 21 51
2019 June 28 26 54
2019 May 34 21 55
2019 April 50 29 79
2019 March 43 17 60
2019 February 27 17 44
2019 January 43 23 66
2018 December 180 45 225
2018 November 280 20 300
2018 October 271 19 290
2018 September 107 14 121
2018 August 51 15 66
2018 July 63 12 75
2018 June 66 12 78
2018 May 93 15 108
2018 April 136 12 148
2018 March 89 5 94
2018 February 165 5 170
2018 January 69 6 75
2017 December 169 8 177
2017 November 90 14 104
2017 October 32 4 36
2017 September 57 16 73
2017 August 83 12 95
2017 July 81 10 91
2017 June 88 7 95
2017 May 81 15 96
2017 April 54 13 67
2017 March 57 6 63
2017 February 27 13 40
2017 January 21 10 31
2016 December 34 11 45
2016 November 19 7 26
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?