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1&#47;2056&#44; respectively&#93;&#41;&#46; Hypergammaglobulinaemia was observed with an IgG kappa monoclonal component&#44; and serologies were read as false positives in the context of hypergammaglobulinaemia&#44; which is why patient was not treated&#46; The patient developed apparent purpura in the lower limbs soon after and cryoglobulins containing polyclonal Ig and monoclonal IgG kappa &#40;essential mixed cryoglobulinaemia&#41; were positive&#46; After ruling out haematological neoplasia &#40;a bone marrow biopsy revealed no signs of multiple myeloma&#41; and HBV&#47;HCV as potential causes&#44; serology tests for <span class="elsevierStyleItalic">Coxiella</span> were requested&#44; and the results &#8211; IgG &#40;phase 2&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;4092&#44; IgM &#40;phase 1&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;64&#44; IgG &#40;phase 1&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;4092 &#8211; were consistent with chronic Q fever&#46; Endocarditis was ruled out and treatment with doxycycline 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day and hydroxychloroquine 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day was initiated&#46; The fever abated and the patient had a favourable outcome&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Symptomatic Q fever is common among adult male patients such as ours&#46; Despite the sudden onset of fever without a focus&#44; which is typical of acute forms&#44; recurrence of symptoms following withdrawal of doxycycline was rather suggestive of chronic Q fever&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Endocarditis is the most common presentation&#44; particularly among immunocompromised patients or patients with valvular heart disease&#46; And yet&#44; surprisingly&#44; endocarditis was ruled out in our patient&#44; who was immunocompromised as a result of his baseline comorbidity &#40;ESCRD undergoing haemodialysis&#41; and neutropenia&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Hepatitis and cirrhosis are also common&#46; In our patient&#44; who had a history of moderate alcoholism&#44; transaminasaemia had remained normal before he developed his condition&#46; Liver cirrhosis and splenomegaly were observed in the CT scan&#44; and Q fever may have been a contributing factor&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Anaemia and thrombocytopenia may also occur&#46; Our patient already had nephropathy-related anaemia which was initially refractory to EEAs&#44; probably as a result of Q fever&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Finally&#44; the diagnosis of Q fever was reinforced by the finding of type II cryoglobulinaemia &#40;mono-polyclonal&#41; in the absence of the hepatitis C virus or haematologic neoplasia&#44; as it is one of its potential manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Our patient started treatment with doxycycline and hydroxychloroquine and so far&#44; after 18 months of treatment&#44; the fever has not recurred and the anaemia has resolved&#44; even without EEAs&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; the patient described here is a case of chronic Q fever with blood&#44; liver&#44; and skin involvement&#44; together with secondary cryoglobulinaemia&#46;</p></span>"
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Q fever"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46; Raoult"
                            1 => "T&#46; Marrie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1995"
                        "volumen" => "20"
                        "paginaInicial" => "489"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7756465"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Q fever a review and issues for the next century"
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                            0 => "T&#46;J&#46; Marrie"
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                        "tituloSerie" => "Int J Antimicrob Agents"
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                        "paginaInicial" => "145"
                        "paginaFinal" => "161"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18611796"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Mixed cryoglobulinemia associated with chronic Q fever"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Enzenauer"
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                      ]
                    ]
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                        "tituloSerie" => "J Rheumatol"
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                        "volumen" => "18"
                        "paginaInicial" => "76"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                      "titulo" => "Q fever endocarditis masquerading as mixed cryoglobulinemia type II&#46; A case report and review of the literature"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                        ]
                      ]
                    ]
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                        "volumen" => "6"
                        "paginaInicial" => "32"
                        "link" => array:1 [
                          0 => array:2 [
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Letter to the Editor – Brief Case Reports
Resistant anaemia and mixed cryoglobulinaemia in a patient on haemodialysis in the context of Q fever
Anemia resistente y crioglobulinemia mixta en paciente en hemodiálisis en contexto de fiebre Q
Natalia Allende Burgos
Corresponding author
, Jordi Calls Ginesta
Servicio de Nefrología, Hospital de Manacor, Manacor, Palma de Mallorca, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Q fever caused by <span class="elsevierStyleItalic">Coxiella burnetti</span> may produce acute or chronic clinical manifestation&#44; although most cases are asymptomatic or mild&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Acute presentation of Q fever is characterised by a sudden flu-like syndrome and high-grade fever&#46; Nearly 1&#8211;5&#37; of infected patients develop a chronic form&#44; which can take place months or years after an acute infection&#46; The most common manifestation is endocarditis&#44; especially in immunocompromised patients or in patients with valvular heart disease&#46; Mixed cryoglobulinaemia is rare<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#44;3</span></a> and can be diagnosed using an immunoassay&#46; Seroconversion is usually detected 7&#8211;15 days after the onset of symptoms&#46; Titres of anti-phase II antigens IgG greater than 200 or Titres of anti-phase II antigens IgM greater than 50 are indicative of a recent infection&#44; whereas titres of anti-phase I antigens IgG greater than 800 are suggestive of chronic infection&#46; Mild forms are commonly self-limiting&#46; Doxycycline is the drug of choice if treatment is needed&#46; Hydroxychloroquine and doxycycline are recommended for at least 18 months for the treatment of chronic forms of endocarditis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our patient is a 64-year-old man from Germany who has been living in Mallorca since 2011&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">History</span>&#58; HTN&#44; ischaemic cardiomyopathy that underwent revascularisation &#40;3 stents&#41;&#46; Atrial fibrillation treated with anticoagulation&#46; Moderate alcoholism&#46; End-stage chronic renal disease &#40;ESCRD&#41; receiving haemodialysis with vascular graft access&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In April 2013&#44; the patient started with fever&#44; elevated transaminases &#40;GPT 124&#44; GOT 114&#44; and GGT 100&#41;&#44; and positive CMV IgM&#46; Following 2 weeks of treatment with ganciclovir&#44; the fever abated but the inflammatory parameters remained high &#40;CRP 9&#46;24 and PCT 12&#46;48&#41;&#46; Fever recurred subsequently and neutropenia &#40;up to 1150<span class="elsevierStyleHsp" style=""></span>mcl&#41;&#44; anaemia refractory to erythropoiesis-stimulating agents &#40;ESA&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and thrombocytopenia were associated&#46; Ganciclovir was administered for 3 weeks with <span class="elsevierStyleItalic">Rickettsia</span>- and <span class="elsevierStyleItalic">Coxiella</span>-positive serologies &#40;IgG using IIF&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Although the patient denied any animal or tick bites&#44; treatment with doxycycline &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h&#41; was initiated due to a suspected <span class="elsevierStyleItalic">Coxiella&#47;Rickettsia</span> infection and after ruling out endocarditis using a transthoracic echocardiogram&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient still had fever and neutropenia seven days after treatment began&#46; A CT scan of the abdomen and chest revealed liver cirrhosis and splenomegaly&#46; HCV and HBV serologies were negative&#46; Finally&#44; <span class="elsevierStyleItalic">Serratia marcescens</span> was isolated in a sputum culture&#44; and fever subsided following 5 days of treatment with ceftazidime&#46; The patient remained without fever after 2 weeks of treatment with ceftazidime and doxycycline&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Fever recurred one month later &#40;June 2013&#41;&#46; The sputum culture and haemocultures were negative&#44; while <span class="elsevierStyleItalic">Rickettsia</span> and <span class="elsevierStyleItalic">Coxiella</span> serologies remained positive &#40;phase 1 IgM and IgG and phase 2 IgM and IgG &#91;1&#47;512&#59; 1&#47;2056&#44; respectively&#93;&#41;&#46; Hypergammaglobulinaemia was observed with an IgG kappa monoclonal component&#44; and serologies were read as false positives in the context of hypergammaglobulinaemia&#44; which is why patient was not treated&#46; The patient developed apparent purpura in the lower limbs soon after and cryoglobulins containing polyclonal Ig and monoclonal IgG kappa &#40;essential mixed cryoglobulinaemia&#41; were positive&#46; After ruling out haematological neoplasia &#40;a bone marrow biopsy revealed no signs of multiple myeloma&#41; and HBV&#47;HCV as potential causes&#44; serology tests for <span class="elsevierStyleItalic">Coxiella</span> were requested&#44; and the results &#8211; IgG &#40;phase 2&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;4092&#44; IgM &#40;phase 1&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;64&#44; IgG &#40;phase 1&#41;<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1&#47;4092 &#8211; were consistent with chronic Q fever&#46; Endocarditis was ruled out and treatment with doxycycline 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day and hydroxychloroquine 200<span class="elsevierStyleHsp" style=""></span>mg&#47;day was initiated&#46; The fever abated and the patient had a favourable outcome&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Symptomatic Q fever is common among adult male patients such as ours&#46; Despite the sudden onset of fever without a focus&#44; which is typical of acute forms&#44; recurrence of symptoms following withdrawal of doxycycline was rather suggestive of chronic Q fever&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Endocarditis is the most common presentation&#44; particularly among immunocompromised patients or patients with valvular heart disease&#46; And yet&#44; surprisingly&#44; endocarditis was ruled out in our patient&#44; who was immunocompromised as a result of his baseline comorbidity &#40;ESCRD undergoing haemodialysis&#41; and neutropenia&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Hepatitis and cirrhosis are also common&#46; In our patient&#44; who had a history of moderate alcoholism&#44; transaminasaemia had remained normal before he developed his condition&#46; Liver cirrhosis and splenomegaly were observed in the CT scan&#44; and Q fever may have been a contributing factor&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Anaemia and thrombocytopenia may also occur&#46; Our patient already had nephropathy-related anaemia which was initially refractory to EEAs&#44; probably as a result of Q fever&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Finally&#44; the diagnosis of Q fever was reinforced by the finding of type II cryoglobulinaemia &#40;mono-polyclonal&#41; in the absence of the hepatitis C virus or haematologic neoplasia&#44; as it is one of its potential manifestations&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Our patient started treatment with doxycycline and hydroxychloroquine and so far&#44; after 18 months of treatment&#44; the fever has not recurred and the anaemia has resolved&#44; even without EEAs&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; the patient described here is a case of chronic Q fever with blood&#44; liver&#44; and skin involvement&#44; together with secondary cryoglobulinaemia&#46;</p></span>"
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                          "autores" => array:4 [
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                            3 => "R&#46;F&#46; Trotta"
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                        "paginaFinal" => "579"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1995"
                        "volumen" => "20"
                        "paginaInicial" => "489"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:1 [
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                        "tituloSerie" => "Int J Antimicrob Agents"
                        "fecha" => "1997"
                        "volumen" => "8"
                        "paginaInicial" => "145"
                        "paginaFinal" => "161"
                        "link" => array:1 [
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                            0 => "R&#46;J&#46; Enzenauer"
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                    ]
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                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1991"
                        "volumen" => "18"
                        "paginaInicial" => "76"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2023203"
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                        0 => array:2 [
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                          "autores" => array:3 [
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                        "volumen" => "6"
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