Baclofen-associated encephalopathy in a hemodialysis patient with hiccups

, L.F. Quintana , A. Lladó , M. Butjosa, J. Santamaría, E. Poch

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Aunque el uso del baclofeno en pacientes en hemodiálisis con hipo intratable se ha descrito como seguro y exitoso a dosis de 5 mg/día, su farmacodinámica y farmacocinética en la insuficiencia renal avanzada es poco conocida. Presentamos el caso de un paciente en hemodiálisis que desarrolló un cuadro de encefalopatía asociado a baclofeno con esta dosis recomendada de la medicación." ] "en" => array:1 [ "resumen" => "Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. 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Nefrología (English Edition)

ISSN: 2013-2514

Nefrología is the official publication of the Spanish Society of Nephrology. The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages. Nefrología follows the publication requirements of the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE).

Indexed in:

MEDLINE, EMBASE, IME , IBECs, Scopus and SCIE/JCR

El baclofeno es un agonista del ácido gamma-amino-butírico (GABA) que se utiliza como relajante muscular de acción central en patologías caracterizadas por espasticidad o en el hipo refractario a otros tratamientos. Aunque el uso del baclofeno en pacientes en hemodiálisis con hipo intratable se ha descrito como seguro y exitoso a dosis de 5 mg/día, su farmacodinámica y farmacocinética en la insuficiencia renal avanzada es poco conocida. Presentamos el caso de un paciente en hemodiálisis que desarrolló un cuadro de encefalopatía asociado a baclofeno con esta dosis recomendada de la medicación.

Palabras clave:

Baclofeno, hipo, encefalopatía, hemodiálisis

Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups. Although encouraging and safe results were provided 5 mg/day in hemodialysis patients, his pharmacokinetic and pharmacodinamic properties are not well known in end stage renal disease. We present here the case of a hemodialysis patient with intractable hiccups who developed baclofen-associated encephalopathy with this recommended dose.

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