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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">We thank Dr&#46; Mubarak for his interest in and comment on our article &#8220;IgM nephropathy in children&#58; clinicopathologic analysis&#8221;<span class="elsevierStyleSup">1</span>&#46; We agree with Dr&#46; Mubarak that IgM nephropathy &#40;IgMN&#41; is a very controversial entity&#44; with variable definitions in the different case series published&#46; As in all series of glomerulopathy cases&#44; the percentage frequency variability depends largely on the subjectivity of diagnosis in many cases&#44; the characteristics of each study population and the denominator used to determine the percentage&#46; We decided use all renal biopsies because it gives us an idea of the total frequency of cases and permit to compare with other glomerulopathies frequencies&#46; In our series&#44; 138 children were biopsied due to nephrotic syndrome&#44; so IgMN percentage frequency in children with nephrotic syndrome was 9&#46;4&#37;&#46; With respect minimum threshold of IgM positivity used for us in order to define IgM Nephropaty was &#8220;&#43;&#43;&#8221;&#46;</p><p class="elsevierStylePara">The evolution time in ours patients was 1 year until 21 years &#40;diagnostic moment until last observation&#41;&#59; but&#44; we used the time between the first evaluation in this hospital and one year more like follow up&#46;</p><p class="elsevierStylePara">Dr&#46; Mubarak his appreciations about Table 1 is correct&#44; we mistake this information because at moment of diagnosis&#44; seven patients present hematuria and three hypertension&#46; About laboratory information&#44; ours creatine values are mg&#47;dL and for proteinuria mg&#47;m<span class="elsevierStyleSup">2</span>&#47;hours&#44; and for last&#44; those patients were classified like cortico-resistant or cortico-dependent in the last evaluations that we found&#46;</p><p class="elsevierStylePara">Thank you for his correction&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;</p>"
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Response to the comment on 'IgM nephropathy in children: clinicopathologic analysis'
Response to the comment on 'IgM nephropathy in children: clinicopathologic analysis'
Luis F. Ariasa, M. Claudia Pradab, Catalia Vélez-Echeverric, Lina M. Serna-Higuitac, Ana K. Serrano-Gayubob, Carolina L. Ochoac, Juan J. Vanegas-Ruizc
a Departamento de Patología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia,
b Servicio de Nefrología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia,
c Servicio de Nefrología, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">We thank Dr&#46; Mubarak for his interest in and comment on our article &#8220;IgM nephropathy in children&#58; clinicopathologic analysis&#8221;<span class="elsevierStyleSup">1</span>&#46; We agree with Dr&#46; Mubarak that IgM nephropathy &#40;IgMN&#41; is a very controversial entity&#44; with variable definitions in the different case series published&#46; As in all series of glomerulopathy cases&#44; the percentage frequency variability depends largely on the subjectivity of diagnosis in many cases&#44; the characteristics of each study population and the denominator used to determine the percentage&#46; We decided use all renal biopsies because it gives us an idea of the total frequency of cases and permit to compare with other glomerulopathies frequencies&#46; In our series&#44; 138 children were biopsied due to nephrotic syndrome&#44; so IgMN percentage frequency in children with nephrotic syndrome was 9&#46;4&#37;&#46; With respect minimum threshold of IgM positivity used for us in order to define IgM Nephropaty was &#8220;&#43;&#43;&#8221;&#46;</p><p class="elsevierStylePara">The evolution time in ours patients was 1 year until 21 years &#40;diagnostic moment until last observation&#41;&#59; but&#44; we used the time between the first evaluation in this hospital and one year more like follow up&#46;</p><p class="elsevierStylePara">Dr&#46; Mubarak his appreciations about Table 1 is correct&#44; we mistake this information because at moment of diagnosis&#44; seven patients present hematuria and three hypertension&#46; About laboratory information&#44; ours creatine values are mg&#47;dL and for proteinuria mg&#47;m<span class="elsevierStyleSup">2</span>&#47;hours&#44; and for last&#44; those patients were classified like cortico-resistant or cortico-dependent in the last evaluations that we found&#46;</p><p class="elsevierStylePara">Thank you for his correction&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;</p>"
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2020 Junio 26 17 43
2020 Mayo 30 28 58
2020 Abril 28 23 51
2020 Marzo 36 10 46
2020 Febrero 36 27 63
2020 Enero 28 23 51
2019 Diciembre 46 23 69
2019 Noviembre 36 18 54
2019 Octubre 16 10 26
2019 Septiembre 27 25 52
2019 Agosto 18 16 34
2019 Julio 35 25 60
2019 Junio 24 13 37
2019 Mayo 31 24 55
2019 Abril 48 26 74
2019 Marzo 40 26 66
2019 Febrero 29 28 57
2019 Enero 26 18 44
2018 Diciembre 101 69 170
2018 Noviembre 166 24 190
2018 Octubre 119 23 142
2018 Septiembre 67 29 96
2018 Agosto 48 20 68
2018 Julio 53 17 70
2018 Junio 57 24 81
2018 Mayo 57 15 72
2018 Abril 74 17 91
2018 Marzo 64 15 79
2018 Febrero 49 9 58
2018 Enero 44 9 53
2017 Diciembre 59 9 68
2017 Noviembre 38 9 47
2017 Octubre 29 10 39
2017 Septiembre 44 9 53
2017 Agosto 40 12 52
2017 Julio 45 13 58
2017 Junio 45 15 60
2017 Mayo 42 13 55
2017 Abril 44 13 57
2017 Marzo 40 8 48
2017 Febrero 31 7 38
2017 Enero 29 6 35
2016 Diciembre 44 10 54
2016 Noviembre 55 15 70
2016 Octubre 74 16 90
2016 Septiembre 100 3 103
2016 Agosto 173 5 178
2016 Julio 185 4 189
2016 Junio 105 0 105
2016 Mayo 140 0 140
2016 Abril 117 0 117
2016 Marzo 86 0 86
2016 Febrero 120 0 120
2016 Enero 122 0 122
2015 Diciembre 123 0 123
2015 Noviembre 101 0 101
2015 Octubre 116 0 116
2015 Septiembre 95 0 95
2015 Agosto 96 0 96
2015 Julio 108 0 108
2015 Junio 50 0 50
2015 Mayo 81 0 81
2015 Abril 40 0 40
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