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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58; </span>Contrast-induced nephropathy &#40;CIN&#41; is a prominent cause of in-hospital acute kidney injury occurring after the administration of intravenous radiocontrast medium&#46; Oxidative stress has been proposed as one of the more important mechanisms in the pathogenesis of CIN&#46; The aim of the present study has been to determine the effect of alpha tocopherol on the reduction of renal damage in a rat model of CIN&#46; <span class="elsevierStyleBold">Methods&#58;</span> Male Sprague Dawley rats were<span class="elsevierStyleBold"> </span>subjected into six groups pretreated with alpha-tocopherol &#40;250 or 500mg&#47;kg&#47;day&#41; or the vehicle tweeen80 for 5 days before the induction of CIN&#46; Renal function and oxidative stress markers&#59; level of malondialdehyde &#40;MDA&#41;&#44; total antioxidant capacity &#40;TAC&#41;&#44; superoxide dismutase &#40;SOD&#41; activity were determined&#46; Kidney tissues were sectioned for pathohistological examination&#46; <span class="elsevierStyleBold">Results&#58; </span>In the contrast media &#40;CM&#41; group&#44; an increase in serum urea and creatinine was found&#46; Tubular necrosis and peritubular capillary congestion were demonstrated in this group&#46; Also&#44; an imbalance of oxidative stress markers&#59; an increase in MDA and a decreased SOD activity in kidney were shown&#46; On the contrary&#44; in CIN-induced rats administrated with alpha-tocopherol group&#44; a significant reduction of renal function and renal MDA&#44; together with a significant increase of renal SOD&#44; were observed&#46; Interestingly&#44; a reduction in MDA and an increase of TAC in serum&#44; along with prevention of tubular injury&#44; were demonstrated in this group&#44; as compared to the CM group&#46; <span class="elsevierStyleBold">Conclusion&#58;</span> This present study demonstrated that alpha tocopherol showed protective effect on the rat renal damage induced CIN&#46; Therefore&#44; this vitamin could be used as an antioxidant to attenuate the radiocontrast oxidative damage&#46;</p>"
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