Búsqueda avanzada
 array:21 [
  "pii" => "X0211699512002349"
  "issn" => "02116995"
  "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2012;32:724-30"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 23955
    "formatos" => array:3 [
      "EPUB" => 320
      "HTML" => 20187
      "PDF" => 3448
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:17 [
      "pii" => "X2013251412002346"
      "issn" => "20132514"
      "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia (English Version). 2012;32:724-30"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9283
        "formatos" => array:3 [
          "EPUB" => 300
          "HTML" => 7975
          "PDF" => 1008
        ]
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Metabolic acidosis and progression of chronic kidney disease: incidence, pathogenesis, and therapeutic options"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "724"
            "paginaFinal" => "730"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Acidosis metabólica y avance de la enfermedad renal crónica: incidencia, patogénesis y opciones terapéuticas"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier España"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11515_16025_38600_en_t211515i_copia.jpg"
                "Alto" => 2005
                "Ancho" => 2166
                "Tamanyo" => 927107
              ]
            ]
            "descripcion" => array:1 [
              "en" => "Randomized prospective trials in the use of oral bicarbonate in patients with CKD"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "WPAHS Division of Nephrology and Hypertension. Allegheny General Hospital, WPAHS, Temple University School of Medicine, wpahs division of nephrology and hypertension Allegheny general hospital, wpahs, temple university school of medicine, Luis M. Ortega, luis M Ortega, Swati Arora"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "WPAHS"
                "apellidos" => "Division of Nephrology and Hypertension. Allegheny General Hospital, WPAHS, Temple University School of Medicine"
              ]
              1 => array:2 [
                "nombre" => "wpahs"
                "apellidos" => "division of nephrology and hypertension Allegheny general hospital, wpahs, temple university school of medicine"
              ]
              2 => array:2 [
                "nombre" => "Luis M."
                "apellidos" => "Ortega"
              ]
              3 => array:2 [
                "nombre" => "luis M"
                "apellidos" => "Ortega"
              ]
              4 => array:2 [
                "nombre" => "Swati"
                "apellidos" => "Arora"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "X0211699512002349"
          "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002349?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002346?idApp=UINPBA000064"
      "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002346/v0_201502091603/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X0211699512002330"
    "issn" => "02116995"
    "doi" => "10.3265/Nefrologia.pre2012.Apr.11384"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2012;32:731-42"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 17852
      "formatos" => array:3 [
        "EPUB" => 338
        "HTML" => 16659
        "PDF" => 855
      ]
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Evaluación del bienestar espiritual en pacientes en hemodiálisis"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "731"
          "paginaFinal" => "742"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Evaluation of spiritual well-being in haemodialysis patients"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11384_16025_43513_es_11384_19759_29302_es_11384_t1.jpg"
              "Alto" => 1057
              "Ancho" => 600
              "Tamanyo" => 322128
            ]
          ]
          "descripcion" => array:1 [
            "es" => "Relación abreviada de los ítems de bienestar espiritual para cada una de las escalas"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Abilio Reig-Ferrer, M. Dolores Arenas, Rosario Ferrer-Cascales, M. Dolores Fernández-Pascual, Natalia Albaladejo-Blázquez, M. Teresa Gil, Vanesa de la Fuente"
          "autores" => array:8 [
            0 => null
            1 => array:2 [
              "nombre" => "Abilio"
              "apellidos" => "Reig-Ferrer"
            ]
            2 => array:2 [
              "nombre" => "M. Dolores"
              "apellidos" => "Arenas"
            ]
            3 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "Ferrer-Cascales"
            ]
            4 => array:2 [
              "nombre" => "M. Dolores"
              "apellidos" => "Fernández-Pascual"
            ]
            5 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Albaladejo-Blázquez"
            ]
            6 => array:2 [
              "nombre" => "M. Teresa"
              "apellidos" => "Gil"
            ]
            7 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "de la Fuente"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X2013251412002338"
        "doi" => "10.3265/Nefrologia.pre2012.Apr.11384"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002338?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002330?idApp=UINPBA000064"
    "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002330/v0_201502091339/es/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X0211699512002357"
    "issn" => "02116995"
    "doi" => "10.3265/Nefrologia.pre2012.Aug.11667"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2012;32:715-23"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7912
      "formatos" => array:3 [
        "EPUB" => 298
        "HTML" => 6911
        "PDF" => 703
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "La transcriptómica del fracaso renal agudo revela una relación entre inflamación y envejecimiento"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "715"
          "paginaFinal" => "723"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Acute kidney injury transcriptomics unveils a relationship between inflammation and ageing"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. Concepción Izquierdo, María Concepción Izquierdo, Ana B. Sanz, M. Dolores Sánchez-Niño, María Dolores Sánchez-Niño, M. Vanessa Pérez-Gómez, María Vanessa Perez-Gomez, Marta Ruiz-Ortega, Jonay Poveda, Olga Ruiz-Andrés, Olga Ruiz-Andres, Adrián M. Ramos, Juan A. Moreno, Jesús Egido, Alberto Ortiz"
          "autores" => array:19 [
            0 => array:2 [
              "nombre" => "M. Concepción"
              "apellidos" => "Izquierdo"
            ]
            1 => array:2 [
              "nombre" => "María Concepción"
              "apellidos" => "Izquierdo"
            ]
            2 => array:2 [
              "nombre" => "Ana B."
              "apellidos" => "Sanz"
            ]
            3 => array:2 [
              "nombre" => "Ana B."
              "apellidos" => "Sanz"
            ]
            4 => array:2 [
              "nombre" => "M. Dolores"
              "apellidos" => "Sánchez-Niño"
            ]
            5 => array:2 [
              "nombre" => "María Dolores"
              "apellidos" => "Sánchez-Niño"
            ]
            6 => array:2 [
              "nombre" => "M. Vanessa"
              "apellidos" => "Pérez-Gómez"
            ]
            7 => array:2 [
              "nombre" => "María Vanessa"
              "apellidos" => "Perez-Gomez"
            ]
            8 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Ruiz-Ortega"
            ]
            9 => array:2 [
              "nombre" => "Jonay"
              "apellidos" => "Poveda"
            ]
            10 => array:2 [
              "nombre" => "Jonay"
              "apellidos" => "Poveda"
            ]
            11 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Ruiz-Andrés"
            ]
            12 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Ruiz-Andres"
            ]
            13 => array:2 [
              "nombre" => "Adrián M."
              "apellidos" => "Ramos"
            ]
            14 => array:2 [
              "nombre" => "Juan A."
              "apellidos" => "Moreno"
            ]
            15 => array:2 [
              "nombre" => "Jesús"
              "apellidos" => "Egido"
            ]
            16 => array:2 [
              "nombre" => "Jesús"
              "apellidos" => "Egido"
            ]
            17 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Ortiz"
            ]
            18 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Ortiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X2013251412002354"
        "doi" => "10.3265/Nefrologia.pre2012.Aug.11667"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002354?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002357?idApp=UINPBA000064"
    "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002357/v0_201502091339/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Acidosis metabólica y avance de la enfermedad renal crónica: incidencia, patogénesis y opciones terapéuticas"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "724"
        "paginaFinal" => "730"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "WPAHS Division of Nephrology and Hypertension. Allegheny General Hospital, WPAHS, Temple University School of Medicine, wpahs division of nephrology and hypertension Allegheny general hospital, wpahs, temple university school of medicine, Luis M. Ortega, luis M Ortega, Swati Arora"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "WPAHS"
            "apellidos" => "Division of Nephrology and Hypertension. Allegheny General Hospital, WPAHS, Temple University School of Medicine"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "wpahs"
            "apellidos" => "division of nephrology and hypertension Allegheny general hospital&#44; wpahs&#44; temple university school of medicine"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:4 [
            "nombre" => "Luis M&#46;"
            "apellidos" => "Ortega"
            "email" => array:1 [
              0 => "lortega&#64;wpahs&#46;0rg"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "luis M"
            "apellidos" => "Ortega"
            "email" => array:1 [
              0 => "lortega&#64;wpahs&#46;0rg"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Swati"
            "apellidos" => "Arora"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => " Allegheny General Hospital, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "nephrology and hypertension, allegheny general hospital, pittsburgh, pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "Nephrology and Hypertension, Allegheny General Hospital. WPAHS, Temple University School of Medicine, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
          3 => array:3 [
            "entidad" => "nephrology and hypertension, Allegheny general hosptial.WPAHS,Temple University School of Medicine, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "affd"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Metabolic acidosis and progression of chronic kidney disease&#58; incidence&#44; pathogenesis&#44; and therapeutic options"
      ]
    ]
    "pdfFichero" => "P1-E544-S3765-A11515.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431657"
          "palabras" => array:1 [
            0 => "Amoniaco"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431659"
          "palabras" => array:1 [
            0 => "Bicarbonato s&#243;dico"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431661"
          "palabras" => array:1 [
            0 => "ERC"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431663"
          "palabras" => array:1 [
            0 => "Acidosis metab&#243;lica"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431665"
          "palabras" => array:1 [
            0 => "Mortalidad"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431658"
          "palabras" => array:1 [
            0 => "Ammonium"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431660"
          "palabras" => array:1 [
            0 => "Sodium bicarbonate"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431662"
          "palabras" => array:1 [
            0 => "CKD"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431664"
          "palabras" => array:1 [
            0 => "Metabolic acidosis"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431666"
          "palabras" => array:1 [
            0 => "Mortality"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara">Hay una prevalencia importante de la acidosis metab&#243;lica en los pacientes que padecen enfermedad renal cr&#243;nica&#44; present&#225;ndose en niveles tempranos de p&#233;rdida de filtrado glomerular&#46; La patog&#233;nesis se basa en la falta de s&#237;ntesis de bicarbonato s&#233;rico con la acumulaci&#243;n de &#225;cidos de naturaleza org&#225;nica e inorg&#225;nica&#44; ocasionando da&#241;o tubulointersticial a trav&#233;s de la retenci&#243;n de amoniaco y el dep&#243;sito de complemento&#44; aunque esta &#250;ltima hip&#243;tesis se ha cuestionado en el pasado&#46; El uso emp&#237;rico de bicarbonato oral representa una opci&#243;n terap&#233;utica interesante&#160;que ha sido utilizada en estudios cl&#237;nicos recientes&#46; La disponibilidad de bicarbonato de sodio oral en sus diversas formas representa una opci&#243;n barata y simple de utilizar para decelerar la progresi&#243;n de la enfermedad renal&#44; sin mencionar las mejoras en el catabolismo proteico&#44; la osteodistrofia renal y la mortalidad&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara">In the chronic kidney disease population metabolic acidosis is prevalent presenting already in the early stages of renal dysfunction&#46; The pathogenesis associates the lack of bicarbonate production with the accumulation of organic&#47;inorganic acids and the development of tubulointerstitial damage through ammonium retention and complement deposition&#46; The empiric use of oral sodium bicarbonate represents an interesting therapeutic option that has been documented in a few clinical trials in human subjects&#46; The availability of oral sodium&#44; in its diverse forms&#44; represents an inexpensive and simple way of treating an entity that could hasten the progression of kidney disease&#44; as well as protein catabolism&#44; bone disease and mortality&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:45 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Kurtz I. Metabolic acidosis of CKD; diagnosis,clinical characteristics\u{A0}and treatment. Am J Kidney Dis 2005;45:978-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15957126" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007;298(17):2038-47. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17986697" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Madias NE. Consequences and therapy of the metabolic acidosis of chronic kidney disease. Pediatr Nephrol 2011;26:19-28. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20526632" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Di Iorio B, Aucella F, Conte G, Cupisti A, Santoro D. A prospective, multicenter, randomized, controlled study: The correction of metabolic acidosis with use of bicarbonate in chronic renal insufficiency (UBI0 study). J Nephrol 2012;25:437-40. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21928233" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Kurtz I. Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. Am J Kidney Dis 2005;45:978-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15957126" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12500213" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Frassetto L, Sebastian A. Age and systemic acid-base equilibrium: Analysis of published data. J Gerontol 1996;51:B91-B99."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hakim RM, Lazarus JM. Biochemical parameters in chronic renal failure. Am J Kidney Dis 1988;11:238-47. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3125741" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Relman AS. Renal acidosis and renal excretion of acid in health and disease. Adv Intern Med 1964;12:295-347. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14268281" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Caravaca F, Arrobas M, Pizarro JL, Esparrago JF. Metabolic acidosis in advanced renal failure:differences between diabetic and nondiabetic patients. Am J Kidney Dis 1999;5:892-8."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Widmer B, Gehardt RE, Harrington JT, Cohen JJ. Serum electrolytes and acid base composition. The influence of graded degrees of chronic renal failure. Arch Int Med 1979;139:1099-102."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Eustace JA, Astor B, Muntner PM, Ikizler A, Coresh J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 2004;65:1031-40. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14871424" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Shah SN, Abramowitz M, Hosletter TH, Melamed ML. Serum bicarbonate levels and the progression of kidney disease:a cohort study. Am J Kidney Dis 2009;54:270-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19394734" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD. Nephrol Dial Transplant 2009;24:1232-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19015169" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Raphael KL, Wei G, Baird BC, Greene T, Beddhu S. Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans. Kidney Int 2011;79:356-62. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20962743" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Dass PD, Kurtz I. Renal ammonia and bicarbonate production in chronic renal failure. Miner Electrolyte Metab 1990;16:308-14. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1980935" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2007;2:162-74. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17699401" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Sabatini S, Kutzman NA. Enzyme activity in obstructive uropathy: Basis for salt wastage and the acidification defect. Kidney Int 1990;37:79-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2153850" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Maclean AJ, Hayslett JP, Klein-Robbenhaar T, Myketey N. Adaptative change in ammonia excretion in renal insufficiency. Kidney Int 1980;17:595-606. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7401460" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tizianello A, Ferrari GD, Garibotto G, Gurreri G, Robaudo C. Renal metabolism of amino acids in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980;65:1162-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7364943" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lameire N, Matthys E. Influence of progressive salt restriction on urinary bicarbonate wasting in uremic acidosis. Am J Kidney Dis 1986;8:151-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3019127" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Battle DC. Segmental characterization of defects in collecting tubule acidification. Kidney Int 1986;30:546-54. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3784293" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Klahr S, Morrissey J. Progression of chronic renal disease. Am J Kidney Dis 2003;41:S3-S7(Suppl 1). <a href="http://www.ncbi.nlm.nih.gov/pubmed/12776302" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gadola L, Noboa O, Marquez MN, Rodriguez MJ, Nin N, Boggia J, et al. Calcium citrate ameliorates the progression of chronic renal injury. Kidney Int 2004;65:1224-30. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15086461" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Jara A, Felsenfeld AJ, Bover J, Kleeman CR. Chronic metabolic acidosis in azotemic rats on a high phosphate diet halts the progression of renal disease. Kidney Int 2000;58:1023-32. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10972667" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Agroyannis B, Tzanatos H, Kopelias I, Fourtounas K,\u{A0}Koutsikos D. Renal ammoniagenesis and tubulointerstitial injury in hypertension. Nephrol Dial Transplant 1995;10:2372-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8808249" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Chodanican MC, Julin C. Angiotensin II stimulates ammoniagensis in canine renal proximal tubular segments. Am J Physiol 1991;260:F16-F27."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nath KA, Hostetter MK, Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 1985;76:667-75. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2993363" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Halperin ML, Eithier JH, Kamel KS. Ammonium excretion in chronic metabolic acidosis: Benefits and risks. Am J Kidney Dis 1989;14:267-71. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2679056" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nath KA, Hostetter MK, Hostetter TH. Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis 1991;17:654-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2042643" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J. Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int 2010;78:1128-35. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20861823" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Mitch WE. Influence of metabolic acidosis on nutrition. Am J Kidney Dis 1997;29:xlvi-xlviii."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tsantoulas DC, McFarlane IG, Portman B, Eddelston ALWF, Williams R. Cell mediated immunity to human Tamm-Horsfall glycoprotein in autoimmune liver disease with renal tubular acidosis. Br Med J 1974;4:491-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/4611578" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wallia R, Greenberg A, Piraino B, Mitro R, Puschett JB. Serum electrolyte patterns in end-stage renal disease. Am J Kidney Dis 1986;8:98. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3090875" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Torres VE, Cowley BDJ, Branden MG, Yoshida I, Gattone VH. Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. Exp Nephrol 2001;9:171-80. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11340301" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Nathan T, Rose T, Simone J, Tran RM. Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. Kidney Int 2007;71:210-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17164833" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roderick P, Willis NS, Blakeley S, Jones C, Tomson P. Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Data Base Syst Rev(1):2007,CD001890."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Rustom R, Grime JS, Costigan M, Maltby P, Hughes A, Taylor W, et al. Oral sodium bicarbonate reduces proximal renal tubular peptide catabolism, ammoniogenesis, and tubular damage in renal patients. Ren Fail 1998;20:371-82. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9574465" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Brito-Ashurst ID, Varagunam M, Raftery MJ, Yaqoop MM. Bicarbonate supplementation slows progression of ckd and improves nutritional status. J Am Soc Nephrol 2009;20:2075-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19608703" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab MH, et al. Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR. Kidney Int 2010;77:617-23. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20072112" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE, et al. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 2010;78:303-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20445497" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J, Broglio K, Sheather SJ. Acid retention accompanies reduced GFR in humans and increase plasma levels of aldosterone and endothelin. Am J Physiol Renal Physiol 2011;300:F830-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21270096" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA. Effect of metabolic acidosis on progression of chronic kidney disease. Am J Physiol Renal Physiol 2011;300:F828-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21307127" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J. Increased tissue acid mediates progressive GFR decline in animals with reduced nephron mass. Kidney Int 2009;75:929-35. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19190678" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney Int 2008;73:192-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17978813" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002349/v0_201502091339/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35404"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisiones cortas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003200000006/v0_201502091338/X0211699512002349/v0_201502091339/es/P1-E544-S3765-A11515.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002349?idApp=UINPBA000064"
]
Compartir
Número actual
Información de la revista
Volver al artículo

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Acidosis metabólica y avance de la enfermedad renal crónica: incidencia, patogénesis y opciones terapéuticas
Metabolic acidosis and progression of chronic kidney disease: incidence, pathogenesis, and therapeutic options
WPAHS Division of Nephrology and Hypertension. Allegheny General Hospital, WPAHS, Temple University School of Medicinea, wpahs division of nephrology and hypertension Allegheny general hospital, wpahs, temple university school of medicineb, Luis M. Ortegac, luis M Ortegad, Swati Arorad
a Allegheny General Hospital, Pittsburgh, Pennsylvania, USA,
b nephrology and hypertension, allegheny general hospital, pittsburgh, pennsylvania, USA,
c Nephrology and Hypertension, Allegheny General Hospital. WPAHS, Temple University School of Medicine, Pittsburgh, Pennsylvania, USA,
d nephrology and hypertension, Allegheny general hosptial.WPAHS,Temple University School of Medicine, Pittsburgh, Pennsylvania, USA,
Leído
35233
Veces
se ha leído el artículo
7372
Total PDF
27861
Total HTML
Compartir estadísticas
 array:21 [
  "pii" => "X0211699512002349"
  "issn" => "02116995"
  "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2012;32:724-30"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 23955
    "formatos" => array:3 [
      "EPUB" => 320
      "HTML" => 20187
      "PDF" => 3448
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:17 [
      "pii" => "X2013251412002346"
      "issn" => "20132514"
      "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia &#40;English Version&#41;. 2012;32:724-30"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9283
        "formatos" => array:3 [
          "EPUB" => 300
          "HTML" => 7975
          "PDF" => 1008
        ]
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "titulo" => "Metabolic acidosis and progression of chronic kidney disease&#58; incidence&#44; pathogenesis&#44; and therapeutic options"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "724"
            "paginaFinal" => "730"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Acidosis metab&#243;lica y avance de la enfermedad renal cr&#243;nica&#58; incidencia&#44; patog&#233;nesis y opciones terap&#233;uticas"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:8 [
            "identificador" => "fig1"
            "etiqueta" => "Tab.  2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "copyright" => "Elsevier Espa&#241;a"
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "11515_16025_38600_en_t211515i_copia.jpg"
                "Alto" => 2005
                "Ancho" => 2166
                "Tamanyo" => 927107
              ]
            ]
            "descripcion" => array:1 [
              "en" => "Randomized prospective trials in the use of oral bicarbonate in patients with CKD"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "WPAHS Division of Nephrology and Hypertension&#46; Allegheny General Hospital&#44; WPAHS&#44; Temple University School of Medicine, wpahs division of nephrology and hypertension Allegheny general hospital&#44; wpahs&#44; temple university school of medicine, Luis M&#46; Ortega, luis M Ortega, Swati Arora"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "WPAHS"
                "apellidos" => "Division of Nephrology and Hypertension&#46; Allegheny General Hospital&#44; WPAHS&#44; Temple University School of Medicine"
              ]
              1 => array:2 [
                "nombre" => "wpahs"
                "apellidos" => "division of nephrology and hypertension Allegheny general hospital&#44; wpahs&#44; temple university school of medicine"
              ]
              2 => array:2 [
                "nombre" => "Luis M&#46;"
                "apellidos" => "Ortega"
              ]
              3 => array:2 [
                "nombre" => "luis M"
                "apellidos" => "Ortega"
              ]
              4 => array:2 [
                "nombre" => "Swati"
                "apellidos" => "Arora"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "X0211699512002349"
          "doi" => "10.3265/Nefrologia.pre2012.Jul.11515"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002349?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002346?idApp=UINPBA000064"
      "url" => "/20132514/0000003200000006/v0_201502091602/X2013251412002346/v0_201502091603/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X0211699512002330"
    "issn" => "02116995"
    "doi" => "10.3265/Nefrologia.pre2012.Apr.11384"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2012;32:731-42"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 17852
      "formatos" => array:3 [
        "EPUB" => 338
        "HTML" => 16659
        "PDF" => 855
      ]
    ]
    "es" => array:12 [
      "idiomaDefecto" => true
      "titulo" => "Evaluaci&#243;n del bienestar espiritual en pacientes en hemodi&#225;lisis"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "731"
          "paginaFinal" => "742"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Evaluation of spiritual well-being in haemodialysis patients"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11384_16025_43513_es_11384_19759_29302_es_11384_t1.jpg"
              "Alto" => 1057
              "Ancho" => 600
              "Tamanyo" => 322128
            ]
          ]
          "descripcion" => array:1 [
            "es" => "Relaci&#243;n abreviada de los &#237;tems de bienestar espiritual para cada una de las escalas"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Abilio Reig-Ferrer, M&#46; Dolores Arenas, Rosario Ferrer-Cascales, M&#46; Dolores Fern&#225;ndez-Pascual, Natalia Albaladejo-Bl&#225;zquez, M&#46; Teresa Gil, Vanesa de la Fuente"
          "autores" => array:8 [
            0 => null
            1 => array:2 [
              "nombre" => "Abilio"
              "apellidos" => "Reig-Ferrer"
            ]
            2 => array:2 [
              "nombre" => "M&#46; Dolores"
              "apellidos" => "Arenas"
            ]
            3 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "Ferrer-Cascales"
            ]
            4 => array:2 [
              "nombre" => "M&#46; Dolores"
              "apellidos" => "Fern&#225;ndez-Pascual"
            ]
            5 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Albaladejo-Bl&#225;zquez"
            ]
            6 => array:2 [
              "nombre" => "M&#46; Teresa"
              "apellidos" => "Gil"
            ]
            7 => array:2 [
              "nombre" => "Vanesa"
              "apellidos" => "de la Fuente"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X2013251412002338"
        "doi" => "10.3265/Nefrologia.pre2012.Apr.11384"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002338?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002330?idApp=UINPBA000064"
    "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002330/v0_201502091339/es/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X0211699512002357"
    "issn" => "02116995"
    "doi" => "10.3265/Nefrologia.pre2012.Aug.11667"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2012;32:715-23"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 7912
      "formatos" => array:3 [
        "EPUB" => 298
        "HTML" => 6911
        "PDF" => 703
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "La transcript&#243;mica del fracaso renal agudo revela una relaci&#243;n entre inflamaci&#243;n y envejecimiento"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "715"
          "paginaFinal" => "723"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Acute kidney injury transcriptomics unveils a relationship between inflammation and ageing"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Concepci&#243;n Izquierdo, Mar&#237;a Concepci&#243;n Izquierdo, Ana B&#46; Sanz, M&#46; Dolores S&#225;nchez-Ni&#241;o, Mar&#237;a Dolores S&#225;nchez-Ni&#241;o, M&#46; Vanessa P&#233;rez-G&#243;mez, Mar&#237;a Vanessa Perez-Gomez, Marta Ruiz-Ortega, Jonay Poveda, Olga Ruiz-Andr&#233;s, Olga Ruiz-Andres, Adri&#225;n M&#46; Ramos, Juan A&#46; Moreno, Jes&#250;s Egido, Alberto Ortiz"
          "autores" => array:19 [
            0 => array:2 [
              "nombre" => "M&#46; Concepci&#243;n"
              "apellidos" => "Izquierdo"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Concepci&#243;n"
              "apellidos" => "Izquierdo"
            ]
            2 => array:2 [
              "nombre" => "Ana B&#46;"
              "apellidos" => "Sanz"
            ]
            3 => array:2 [
              "nombre" => "Ana B&#46;"
              "apellidos" => "Sanz"
            ]
            4 => array:2 [
              "nombre" => "M&#46; Dolores"
              "apellidos" => "S&#225;nchez-Ni&#241;o"
            ]
            5 => array:2 [
              "nombre" => "Mar&#237;a Dolores"
              "apellidos" => "S&#225;nchez-Ni&#241;o"
            ]
            6 => array:2 [
              "nombre" => "M&#46; Vanessa"
              "apellidos" => "P&#233;rez-G&#243;mez"
            ]
            7 => array:2 [
              "nombre" => "Mar&#237;a Vanessa"
              "apellidos" => "Perez-Gomez"
            ]
            8 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Ruiz-Ortega"
            ]
            9 => array:2 [
              "nombre" => "Jonay"
              "apellidos" => "Poveda"
            ]
            10 => array:2 [
              "nombre" => "Jonay"
              "apellidos" => "Poveda"
            ]
            11 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Ruiz-Andr&#233;s"
            ]
            12 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Ruiz-Andres"
            ]
            13 => array:2 [
              "nombre" => "Adri&#225;n M&#46;"
              "apellidos" => "Ramos"
            ]
            14 => array:2 [
              "nombre" => "Juan A&#46;"
              "apellidos" => "Moreno"
            ]
            15 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Egido"
            ]
            16 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Egido"
            ]
            17 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Ortiz"
            ]
            18 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Ortiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X2013251412002354"
        "doi" => "10.3265/Nefrologia.pre2012.Aug.11667"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412002354?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002357?idApp=UINPBA000064"
    "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002357/v0_201502091339/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Acidosis metab&#243;lica y avance de la enfermedad renal cr&#243;nica&#58; incidencia&#44; patog&#233;nesis y opciones terap&#233;uticas"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "724"
        "paginaFinal" => "730"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "WPAHS Division of Nephrology and Hypertension&#46; Allegheny General Hospital&#44; WPAHS&#44; Temple University School of Medicine, wpahs division of nephrology and hypertension Allegheny general hospital&#44; wpahs&#44; temple university school of medicine, Luis M&#46; Ortega, luis M Ortega, Swati Arora"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "WPAHS"
            "apellidos" => "Division of Nephrology and Hypertension&#46; Allegheny General Hospital&#44; WPAHS&#44; Temple University School of Medicine"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "wpahs"
            "apellidos" => "division of nephrology and hypertension Allegheny general hospital&#44; wpahs&#44; temple university school of medicine"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:4 [
            "nombre" => "Luis M&#46;"
            "apellidos" => "Ortega"
            "email" => array:1 [
              0 => "lortega&#64;wpahs&#46;0rg"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "luis M"
            "apellidos" => "Ortega"
            "email" => array:1 [
              0 => "lortega&#64;wpahs&#46;0rg"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Swati"
            "apellidos" => "Arora"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "affd"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => " Allegheny General Hospital, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "nephrology and hypertension, allegheny general hospital, pittsburgh, pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "Nephrology and Hypertension, Allegheny General Hospital. WPAHS, Temple University School of Medicine, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
          3 => array:3 [
            "entidad" => "nephrology and hypertension, Allegheny general hosptial.WPAHS,Temple University School of Medicine, Pittsburgh, Pennsylvania, USA, "
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "affd"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Metabolic acidosis and progression of chronic kidney disease&#58; incidence&#44; pathogenesis&#44; and therapeutic options"
      ]
    ]
    "pdfFichero" => "P1-E544-S3765-A11515.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431657"
          "palabras" => array:1 [
            0 => "Amoniaco"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431659"
          "palabras" => array:1 [
            0 => "Bicarbonato s&#243;dico"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431661"
          "palabras" => array:1 [
            0 => "ERC"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431663"
          "palabras" => array:1 [
            0 => "Acidosis metab&#243;lica"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec431665"
          "palabras" => array:1 [
            0 => "Mortalidad"
          ]
        ]
      ]
      "en" => array:5 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431658"
          "palabras" => array:1 [
            0 => "Ammonium"
          ]
        ]
        1 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431660"
          "palabras" => array:1 [
            0 => "Sodium bicarbonate"
          ]
        ]
        2 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431662"
          "palabras" => array:1 [
            0 => "CKD"
          ]
        ]
        3 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431664"
          "palabras" => array:1 [
            0 => "Metabolic acidosis"
          ]
        ]
        4 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec431666"
          "palabras" => array:1 [
            0 => "Mortality"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<p class="elsevierStylePara">Hay una prevalencia importante de la acidosis metab&#243;lica en los pacientes que padecen enfermedad renal cr&#243;nica&#44; present&#225;ndose en niveles tempranos de p&#233;rdida de filtrado glomerular&#46; La patog&#233;nesis se basa en la falta de s&#237;ntesis de bicarbonato s&#233;rico con la acumulaci&#243;n de &#225;cidos de naturaleza org&#225;nica e inorg&#225;nica&#44; ocasionando da&#241;o tubulointersticial a trav&#233;s de la retenci&#243;n de amoniaco y el dep&#243;sito de complemento&#44; aunque esta &#250;ltima hip&#243;tesis se ha cuestionado en el pasado&#46; El uso emp&#237;rico de bicarbonato oral representa una opci&#243;n terap&#233;utica interesante&#160;que ha sido utilizada en estudios cl&#237;nicos recientes&#46; La disponibilidad de bicarbonato de sodio oral en sus diversas formas representa una opci&#243;n barata y simple de utilizar para decelerar la progresi&#243;n de la enfermedad renal&#44; sin mencionar las mejoras en el catabolismo proteico&#44; la osteodistrofia renal y la mortalidad&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<p class="elsevierStylePara">In the chronic kidney disease population metabolic acidosis is prevalent presenting already in the early stages of renal dysfunction&#46; The pathogenesis associates the lack of bicarbonate production with the accumulation of organic&#47;inorganic acids and the development of tubulointerstitial damage through ammonium retention and complement deposition&#46; The empiric use of oral sodium bicarbonate represents an interesting therapeutic option that has been documented in a few clinical trials in human subjects&#46; The availability of oral sodium&#44; in its diverse forms&#44; represents an inexpensive and simple way of treating an entity that could hasten the progression of kidney disease&#44; as well as protein catabolism&#44; bone disease and mortality&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:45 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Kurtz I. Metabolic acidosis of CKD; diagnosis,clinical characteristics\u{A0}and treatment. Am J Kidney Dis 2005;45:978-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15957126" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007;298(17):2038-47. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17986697" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Madias NE. Consequences and therapy of the metabolic acidosis of chronic kidney disease. Pediatr Nephrol 2011;26:19-28. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20526632" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Di Iorio B, Aucella F, Conte G, Cupisti A, Santoro D. A prospective, multicenter, randomized, controlled study: The correction of metabolic acidosis with use of bicarbonate in chronic renal insufficiency (UBI0 study). J Nephrol 2012;25:437-40. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21928233" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Kurtz I. Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. Am J Kidney Dis 2005;45:978-93. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15957126" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12. <a href="http://www.ncbi.nlm.nih.gov/pubmed/12500213" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Frassetto L, Sebastian A. Age and systemic acid-base equilibrium: Analysis of published data. J Gerontol 1996;51:B91-B99."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Hakim RM, Lazarus JM. Biochemical parameters in chronic renal failure. Am J Kidney Dis 1988;11:238-47. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3125741" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Relman AS. Renal acidosis and renal excretion of acid in health and disease. Adv Intern Med 1964;12:295-347. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14268281" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Caravaca F, Arrobas M, Pizarro JL, Esparrago JF. Metabolic acidosis in advanced renal failure:differences between diabetic and nondiabetic patients. Am J Kidney Dis 1999;5:892-8."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Widmer B, Gehardt RE, Harrington JT, Cohen JJ. Serum electrolytes and acid base composition. The influence of graded degrees of chronic renal failure. Arch Int Med 1979;139:1099-102."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Eustace JA, Astor B, Muntner PM, Ikizler A, Coresh J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 2004;65:1031-40. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14871424" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Shah SN, Abramowitz M, Hosletter TH, Melamed ML. Serum bicarbonate levels and the progression of kidney disease:a cohort study. Am J Kidney Dis 2009;54:270-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19394734" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD. Nephrol Dial Transplant 2009;24:1232-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19015169" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Raphael KL, Wei G, Baird BC, Greene T, Beddhu S. Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans. Kidney Int 2011;79:356-62. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20962743" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Dass PD, Kurtz I. Renal ammonia and bicarbonate production in chronic renal failure. Miner Electrolyte Metab 1990;16:308-14. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1980935" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2007;2:162-74. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17699401" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Sabatini S, Kutzman NA. Enzyme activity in obstructive uropathy: Basis for salt wastage and the acidification defect. Kidney Int 1990;37:79-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2153850" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Maclean AJ, Hayslett JP, Klein-Robbenhaar T, Myketey N. Adaptative change in ammonia excretion in renal insufficiency. Kidney Int 1980;17:595-606. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7401460" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tizianello A, Ferrari GD, Garibotto G, Gurreri G, Robaudo C. Renal metabolism of amino acids in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980;65:1162-73. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7364943" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Lameire N, Matthys E. Influence of progressive salt restriction on urinary bicarbonate wasting in uremic acidosis. Am J Kidney Dis 1986;8:151-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3019127" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Battle DC. Segmental characterization of defects in collecting tubule acidification. Kidney Int 1986;30:546-54. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3784293" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Klahr S, Morrissey J. Progression of chronic renal disease. Am J Kidney Dis 2003;41:S3-S7(Suppl 1). <a href="http://www.ncbi.nlm.nih.gov/pubmed/12776302" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Gadola L, Noboa O, Marquez MN, Rodriguez MJ, Nin N, Boggia J, et al. Calcium citrate ameliorates the progression of chronic renal injury. Kidney Int 2004;65:1224-30. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15086461" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Jara A, Felsenfeld AJ, Bover J, Kleeman CR. Chronic metabolic acidosis in azotemic rats on a high phosphate diet halts the progression of renal disease. Kidney Int 2000;58:1023-32. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10972667" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Agroyannis B, Tzanatos H, Kopelias I, Fourtounas K,\u{A0}Koutsikos D. Renal ammoniagenesis and tubulointerstitial injury in hypertension. Nephrol Dial Transplant 1995;10:2372-3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8808249" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Chodanican MC, Julin C. Angiotensin II stimulates ammoniagensis in canine renal proximal tubular segments. Am J Physiol 1991;260:F16-F27."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nath KA, Hostetter MK, Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 1985;76:667-75. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2993363" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Halperin ML, Eithier JH, Kamel KS. Ammonium excretion in chronic metabolic acidosis: Benefits and risks. Am J Kidney Dis 1989;14:267-71. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2679056" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nath KA, Hostetter MK, Hostetter TH. Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis 1991;17:654-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/2042643" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J. Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int 2010;78:1128-35. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20861823" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Mitch WE. Influence of metabolic acidosis on nutrition. Am J Kidney Dis 1997;29:xlvi-xlviii."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Tsantoulas DC, McFarlane IG, Portman B, Eddelston ALWF, Williams R. Cell mediated immunity to human Tamm-Horsfall glycoprotein in autoimmune liver disease with renal tubular acidosis. Br Med J 1974;4:491-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/4611578" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wallia R, Greenberg A, Piraino B, Mitro R, Puschett JB. Serum electrolyte patterns in end-stage renal disease. Am J Kidney Dis 1986;8:98. <a href="http://www.ncbi.nlm.nih.gov/pubmed/3090875" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Torres VE, Cowley BDJ, Branden MG, Yoshida I, Gattone VH. Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. Exp Nephrol 2001;9:171-80. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11340301" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Nathan T, Rose T, Simone J, Tran RM. Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. Kidney Int 2007;71:210-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17164833" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Roderick P, Willis NS, Blakeley S, Jones C, Tomson P. Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Data Base Syst Rev(1):2007,CD001890."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Rustom R, Grime JS, Costigan M, Maltby P, Hughes A, Taylor W, et al. Oral sodium bicarbonate reduces proximal renal tubular peptide catabolism, ammoniogenesis, and tubular damage in renal patients. Ren Fail 1998;20:371-82. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9574465" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Brito-Ashurst ID, Varagunam M, Raftery MJ, Yaqoop MM. Bicarbonate supplementation slows progression of ckd and improves nutritional status. J Am Soc Nephrol 2009;20:2075-84. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19608703" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab MH, et al. Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR. Kidney Int 2010;77:617-23. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20072112" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE, et al. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 2010;78:303-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20445497" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J, Broglio K, Sheather SJ. Acid retention accompanies reduced GFR in humans and increase plasma levels of aldosterone and endothelin. Am J Physiol Renal Physiol 2011;300:F830-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21270096" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Kraut JA. Effect of metabolic acidosis on progression of chronic kidney disease. Am J Physiol Renal Physiol 2011;300:F828-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21307127" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Wesson DE, Simoni J. Increased tissue acid mediates progressive GFR decline in animals with reduced nephron mass. Kidney Int 2009;75:929-35. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19190678" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney Int 2008;73:192-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17978813" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02116995/0000003200000006/v0_201502091338/X0211699512002349/v0_201502091339/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35404"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Revisiones cortas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003200000006/v0_201502091338/X0211699512002349/v0_201502091339/es/P1-E544-S3765-A11515.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512002349?idApp=UINPBA000064"
]
Información del artículo
ISSN: 02116995
Idioma original: Español
DOI:10.3265/Nefrologia.pre2012.Jul.11515
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 9 13 22
2024 Octubre 102 38 140
2024 Septiembre 94 35 129
2024 Agosto 103 73 176
2024 Julio 91 37 128
2024 Junio 96 95 191
2024 Mayo 78 49 127
2024 Abril 88 57 145
2024 Marzo 71 39 110
2024 Febrero 72 44 116
2024 Enero 59 29 88
2023 Diciembre 69 59 128
2023 Noviembre 90 40 130
2023 Octubre 78 45 123
2023 Septiembre 86 38 124
2023 Agosto 98 33 131
2023 Julio 99 48 147
2023 Junio 109 27 136
2023 Mayo 96 57 153
2023 Abril 50 27 77
2023 Marzo 87 37 124
2023 Febrero 46 30 76
2023 Enero 84 49 133
2022 Diciembre 91 36 127
2022 Noviembre 78 37 115
2022 Octubre 140 55 195
2022 Septiembre 108 66 174
2022 Agosto 74 66 140
2022 Julio 84 73 157
2022 Junio 85 83 168
2022 Mayo 107 71 178
2022 Abril 101 68 169
2022 Marzo 73 68 141
2022 Febrero 113 60 173
2022 Enero 116 74 190
2021 Diciembre 53 75 128
2021 Noviembre 111 70 181
2021 Octubre 115 84 199
2021 Septiembre 113 71 184
2021 Agosto 114 71 185
2021 Julio 78 47 125
2021 Junio 103 44 147
2021 Mayo 113 76 189
2021 Abril 183 94 277
2021 Marzo 210 63 273
2021 Febrero 113 28 141
2021 Enero 105 42 147
2020 Diciembre 140 51 191
2020 Noviembre 207 114 321
2020 Octubre 214 110 324
2020 Septiembre 247 104 351
2020 Agosto 197 81 278
2020 Julio 367 110 477
2020 Junio 293 169 462
2020 Mayo 439 202 641
2020 Abril 486 194 680
2020 Marzo 467 172 639
2020 Febrero 477 197 674
2020 Enero 605 196 801
2019 Diciembre 604 159 763
2019 Noviembre 869 271 1140
2019 Octubre 533 308 841
2019 Septiembre 817 290 1107
2019 Agosto 639 247 886
2019 Julio 592 204 796
2019 Junio 622 259 881
2019 Mayo 695 266 961
2019 Abril 633 225 858
2019 Marzo 367 195 562
2019 Febrero 202 84 286
2019 Enero 184 121 305
2018 Diciembre 307 76 383
2018 Noviembre 431 29 460
2018 Octubre 404 20 424
2018 Septiembre 312 23 335
2018 Agosto 333 23 356
2018 Julio 287 27 314
2018 Junio 460 22 482
2018 Mayo 523 26 549
2018 Abril 291 15 306
2018 Marzo 200 13 213
2018 Febrero 122 8 130
2018 Enero 91 14 105
2017 Diciembre 108 12 120
2017 Noviembre 98 18 116
2017 Octubre 100 18 118
2017 Septiembre 100 13 113
2017 Agosto 96 14 110
2017 Julio 90 15 105
2017 Junio 121 18 139
2017 Mayo 125 14 139
2017 Abril 94 11 105
2017 Marzo 62 7 69
2017 Febrero 63 13 76
2017 Enero 46 7 53
2016 Diciembre 87 11 98
2016 Noviembre 123 12 135
2016 Octubre 138 13 151
2016 Septiembre 195 12 207
2016 Agosto 264 8 272
2016 Julio 222 10 232
2016 Junio 173 0 173
2016 Mayo 159 0 159
2016 Abril 159 0 159
2016 Marzo 177 0 177
2016 Febrero 200 0 200
2016 Enero 171 0 171
2015 Diciembre 191 0 191
2015 Noviembre 161 0 161
2015 Octubre 207 0 207
2015 Septiembre 138 0 138
2015 Agosto 183 0 183
2015 Julio 181 0 181
2015 Junio 149 0 149
2015 Mayo 312 0 312
2015 Abril 83 0 83
2015 Febrero 3992 0 3992
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Suscríbase a la newsletter

Open access
Esta obra está licenciada por una Licencia Creative Commons Attribution 4.0 International License.
Creative Commons License
Publique en
Nefrología
NEFROLOGÍA
AL DÍA
Idiomas
Nefrología
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?