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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">Cholesterol crystal embolism &#40;CCE&#41; is characterized by multi-system organ dysfunction resulting from occlusion of arteries by atheromatous plaque&#46; Most CCE occur following vascular surgery or radiological procedures&#44; and the CCE which occur without history of interventional operation or surgery is often called &#8220;spontaneous CCE&#8221;&#46;<span class="elsevierStyleSup">1</span> However&#44; CCE is commonly accompanied by eosinophilia which is an important characteristic of allergy&#46; Although eosinophilia is generally considered as the secondary reaction after CCE occurring&#44; allergic disease has been proved to be the risk factor of atherosclerotic disease&#46;<span class="elsevierStyleSup">2-4</span> So the relationship between CCE and allergy is still deserved to discuss&#46; Here we describe a case of CCE which occurred after the attack of allergic disease&#46; The patient had a long history of allergic disease &#40;allergic asthma and eczema&#41; over 20 years and an acute attack of eczema and asthma before kidney function decreasing&#46; Satisfactory treatment was obtained with only corticosteroid&#46; This case is a direct proof that allergy is not only the secondary reaction&#44; but also be one of the important precipitating factors of CCE&#46;</p><p class="elsevierStylePara">One month before admission&#44; a 71-year-old male presented with asthma and eczema&#46; Then he had lower limb edema&#44; anorexia&#44; and toe pain&#46; He had a long history of eczema and asthma over 20 years&#44; with no history of chest pain&#44; anticoagulant therapy&#44; cardiac catheterization&#44; or angiography&#46; Urinary sediment showed BLD&#177;&#44; PRO&#177;&#46; Blood chemistry showed renal function insufficiency &#40;BUN&#58; 118&#46;8mg&#47;dL&#44; Cr&#58; 4&#46;28mg&#47;dL&#41;&#46; Blood routine showed anemia &#40;90g&#47;L&#41;&#44; thrombocytopenia &#40;81x10<span class="elsevierStyleSup">9</span>&#47;L&#59; normal range&#44; 100 to 300&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41; and eosinophilia &#40;absolute eosinophil count&#44; 1&#46;6&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#59; normal range&#44; 0 to 0&#46;5&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#46; Immunological examination showed increased IgE level &#40;3080IU&#47;mL&#59; normal range&#44; 0 to 165IU&#47;mL&#41;&#46; The symptoms got worse gradually and the serum Cr had increased to 6&#46;72mg&#47;dL before admission&#46; On admission&#44; the patient presented with marked lower-extremity pitting edema with bilateral pre-tibial skin eczema&#46; Feet pulses were preserved&#46; The skin temperature of the first one-third of the dorsal feet decreased&#46; Cyanosis was present in the toes with overt tenderness&#46;</p><p class="elsevierStylePara">On admission&#44; serum creatinine had increased to 7&#46;88mg&#47;dL&#46; Urinalysis showed slight proteinuria &#40;272mg&#47;24h&#41; and increased N-acetylglucosaminidase &#40;29&#46;9U&#47;gCr&#59; normal range&#44; 2-21&#46;6U&#47;gCr&#41;&#46; IgE level was very high &#40;3650IU&#47;mL&#41;&#46; Doppler ultrasonic imaging study of arteries revealed atherosclerosis and small mural plaques of bifurcations for the common carotid artery&#44; the internal carotid artery and the proximal and middle vertebral artery&#46;</p><p class="elsevierStylePara">Percutaneous kidney biopsy was performed&#46; The results revealed as follows &#40;Figure 1 A&#41;&#46; Among all 12 glomerulus&#44; 5 glomerulus showed ischemic global sclerosis and 2 glomerulus showed ischemic atrophy&#46; Others showed diffuse slight to mild proliferation of glomerular mesangial cells&#46; Multifocal tubular atrophy and interstitial fibrosis were present and accompanied by focal infiltration of mononuclear cells&#44; neutrophils and eosinophils in the interstitium&#46; The most noticeable changes were found within the small arteries&#44; arterioles and vascular pole of the glomeruli presenting with cholesterol crystal gaps&#46; On immunofluorescence&#44; mesangial deposits of FRA &#40;&#43;&#41; were present while IgA&#44; IgG&#44; IgM&#44; C3&#44; and C1q were weak or negative&#46;</p><p class="elsevierStylePara">Although the creatinine clearance rate &#40;Ccr&#41; was as low as 7&#46;3ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; hemodialysis was not administered immediately because of no oliguria&#46; Intravenous methylprednisolone was administered at a dose of 40mg&#47;day&#46; Three days later&#44; the patient&#8217;s general condition improved dramatically&#46; Pain of toes was obviously relieved and no further cutaneous lesions appeared&#46; One week after treatment&#44; the skin temperature of feet increased and the cyanosis turned shallower than before&#46; Blood routine showed eosinophil count decreased to 0&#46;18&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#46; Serum creatinine and IgE decreased to 5&#46;57mg&#47;dL and 2970IU&#47;mL&#44; respectively&#46; Oral triamcinolone was given at a dose of 24mg&#47;day&#46; Three weeks after treatment&#44; serum creatinine decreased to 4&#46;26mg&#47;dL&#46; Pre-tibial skin eczema and pain of toes diminished&#46; The temperature of feet skin recovered&#46; Five weeks after treatment&#44; serum creatinine decreased to 2&#46;69mg&#47;dL&#46; Eosinophil count turned normal&#46; Steroids were tapered 10&#37; every 2-4 weeks&#46; Triamcinolone has been tapered to 4 mg&#47;day for maintenance treatment without CCE relapse so far&#46; The serum creatinine of the patient was 2&#46;81mg&#47;dL during last visit &#40;Figure 1 B&#41;&#46;</p><p class="elsevierStylePara">The relationship between CCE and autoimmunity is an interesting issue&#46; Details of the inflammatory response have been documented in animal models that cholesterol emboli could not only mechanically occlude the vessel but also trigger an inflammatory reaction&#46;<span class="elsevierStyleSup">5</span> Although the role of immune system in the pathogenesis of CCE was only considered to be an inflammatory response after embolism&#44; opposite proofs have also existed&#46; Recently&#44; there were two important studies which showed a significant correlation between allergic disease and atherosclerosis&#46; In the Bruneck study of 826 middle aged and elderly Italian subjects&#44; the risk for atherosclerosis development and progression increased significantly for 32 subjects with allergic disorders&#46; Furthermore&#44; serum IgE levels were significantly raised in subjects in whom atherosclerosis had developed or progressed&#46;<span class="elsevierStyleSup">2</span> In the ARMY study which took 141 male Austrian subjects aged 17 and 18 years&#44; the vascular intima-media thickness &#40;IMT&#41; measured by ultrasonography of the 34 subjects diagnosed as having allergic disease was higher than the healthy subjects&#46;<span class="elsevierStyleSup">2&#44;3</span> Although the exact mechanism is still not fully understood&#44; components of the allergic process such as leukotrienes and mast cells may be involved in atherogenesis&#46;<span class="elsevierStyleSup">2</span> Furthermore&#44; IgE has been proved to be able to promote atherogenesis in Apoe<span class="elsevierStyleSup">-&#47;-</span> mice&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">There has not been a definite consensus of the treatment of CCE by now&#46;<span class="elsevierStyleSup">6&#44;7</span> Although the use of corticosteroid is still controversial&#44; our patient received only corticosteroid treatment without other above drugs and satisfactory results were obtained&#46; Previous reports indicated that Anticoagulant therapy&#44; which is generally essential in hemodialysis&#44; was harmful to patients with CCE because it was a potent risk factor for plaque rupture and cholesterol embolism&#46;<span class="elsevierStyleSup">8</span> Since the present patient was cured successfully with corticosteroid&#44; hemodialysis was avoided and the renal function kept stable to date&#46; So we think treatment with corticosteroid should be a recommended alternative for patients with CCE&#44; especially for patients who had obvious allergic conditions&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest<br></br>&#160;</span></p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;<span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><a href="grande&#47;11652&#95;108&#95;34154&#95;en&#95;f114&#46;jpg" class="elsevierStyleCrossRefs"><img src="11652_108_34154_en_f114.jpg" alt="The kidney biopsy and clinical course of the patient"></img></a></p><p class="elsevierStylePara">Figure 1&#46; The kidney biopsy and clinical course of the patient</p>"
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Acute kidney injury induced by allergic conditions-associated renal cholesterol crystal embolism
Acute kidney injury induced by allergic conditions-associated renal cholesterol crystal embolism
Tie-kun Yana, Xiao-li Lia, Yang Xuea, Li Weia, Shan Lina
a Department of Nephrology, General Hospital of Tianjin Medical University, Tianjin, China,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">Cholesterol crystal embolism &#40;CCE&#41; is characterized by multi-system organ dysfunction resulting from occlusion of arteries by atheromatous plaque&#46; Most CCE occur following vascular surgery or radiological procedures&#44; and the CCE which occur without history of interventional operation or surgery is often called &#8220;spontaneous CCE&#8221;&#46;<span class="elsevierStyleSup">1</span> However&#44; CCE is commonly accompanied by eosinophilia which is an important characteristic of allergy&#46; Although eosinophilia is generally considered as the secondary reaction after CCE occurring&#44; allergic disease has been proved to be the risk factor of atherosclerotic disease&#46;<span class="elsevierStyleSup">2-4</span> So the relationship between CCE and allergy is still deserved to discuss&#46; Here we describe a case of CCE which occurred after the attack of allergic disease&#46; The patient had a long history of allergic disease &#40;allergic asthma and eczema&#41; over 20 years and an acute attack of eczema and asthma before kidney function decreasing&#46; Satisfactory treatment was obtained with only corticosteroid&#46; This case is a direct proof that allergy is not only the secondary reaction&#44; but also be one of the important precipitating factors of CCE&#46;</p><p class="elsevierStylePara">One month before admission&#44; a 71-year-old male presented with asthma and eczema&#46; Then he had lower limb edema&#44; anorexia&#44; and toe pain&#46; He had a long history of eczema and asthma over 20 years&#44; with no history of chest pain&#44; anticoagulant therapy&#44; cardiac catheterization&#44; or angiography&#46; Urinary sediment showed BLD&#177;&#44; PRO&#177;&#46; Blood chemistry showed renal function insufficiency &#40;BUN&#58; 118&#46;8mg&#47;dL&#44; Cr&#58; 4&#46;28mg&#47;dL&#41;&#46; Blood routine showed anemia &#40;90g&#47;L&#41;&#44; thrombocytopenia &#40;81x10<span class="elsevierStyleSup">9</span>&#47;L&#59; normal range&#44; 100 to 300&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41; and eosinophilia &#40;absolute eosinophil count&#44; 1&#46;6&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#59; normal range&#44; 0 to 0&#46;5&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#46; Immunological examination showed increased IgE level &#40;3080IU&#47;mL&#59; normal range&#44; 0 to 165IU&#47;mL&#41;&#46; The symptoms got worse gradually and the serum Cr had increased to 6&#46;72mg&#47;dL before admission&#46; On admission&#44; the patient presented with marked lower-extremity pitting edema with bilateral pre-tibial skin eczema&#46; Feet pulses were preserved&#46; The skin temperature of the first one-third of the dorsal feet decreased&#46; Cyanosis was present in the toes with overt tenderness&#46;</p><p class="elsevierStylePara">On admission&#44; serum creatinine had increased to 7&#46;88mg&#47;dL&#46; Urinalysis showed slight proteinuria &#40;272mg&#47;24h&#41; and increased N-acetylglucosaminidase &#40;29&#46;9U&#47;gCr&#59; normal range&#44; 2-21&#46;6U&#47;gCr&#41;&#46; IgE level was very high &#40;3650IU&#47;mL&#41;&#46; Doppler ultrasonic imaging study of arteries revealed atherosclerosis and small mural plaques of bifurcations for the common carotid artery&#44; the internal carotid artery and the proximal and middle vertebral artery&#46;</p><p class="elsevierStylePara">Percutaneous kidney biopsy was performed&#46; The results revealed as follows &#40;Figure 1 A&#41;&#46; Among all 12 glomerulus&#44; 5 glomerulus showed ischemic global sclerosis and 2 glomerulus showed ischemic atrophy&#46; Others showed diffuse slight to mild proliferation of glomerular mesangial cells&#46; Multifocal tubular atrophy and interstitial fibrosis were present and accompanied by focal infiltration of mononuclear cells&#44; neutrophils and eosinophils in the interstitium&#46; The most noticeable changes were found within the small arteries&#44; arterioles and vascular pole of the glomeruli presenting with cholesterol crystal gaps&#46; On immunofluorescence&#44; mesangial deposits of FRA &#40;&#43;&#41; were present while IgA&#44; IgG&#44; IgM&#44; C3&#44; and C1q were weak or negative&#46;</p><p class="elsevierStylePara">Although the creatinine clearance rate &#40;Ccr&#41; was as low as 7&#46;3ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; hemodialysis was not administered immediately because of no oliguria&#46; Intravenous methylprednisolone was administered at a dose of 40mg&#47;day&#46; Three days later&#44; the patient&#8217;s general condition improved dramatically&#46; Pain of toes was obviously relieved and no further cutaneous lesions appeared&#46; One week after treatment&#44; the skin temperature of feet increased and the cyanosis turned shallower than before&#46; Blood routine showed eosinophil count decreased to 0&#46;18&#215;10<span class="elsevierStyleSup">9</span>&#47;L&#46; Serum creatinine and IgE decreased to 5&#46;57mg&#47;dL and 2970IU&#47;mL&#44; respectively&#46; Oral triamcinolone was given at a dose of 24mg&#47;day&#46; Three weeks after treatment&#44; serum creatinine decreased to 4&#46;26mg&#47;dL&#46; Pre-tibial skin eczema and pain of toes diminished&#46; The temperature of feet skin recovered&#46; Five weeks after treatment&#44; serum creatinine decreased to 2&#46;69mg&#47;dL&#46; Eosinophil count turned normal&#46; Steroids were tapered 10&#37; every 2-4 weeks&#46; Triamcinolone has been tapered to 4 mg&#47;day for maintenance treatment without CCE relapse so far&#46; The serum creatinine of the patient was 2&#46;81mg&#47;dL during last visit &#40;Figure 1 B&#41;&#46;</p><p class="elsevierStylePara">The relationship between CCE and autoimmunity is an interesting issue&#46; Details of the inflammatory response have been documented in animal models that cholesterol emboli could not only mechanically occlude the vessel but also trigger an inflammatory reaction&#46;<span class="elsevierStyleSup">5</span> Although the role of immune system in the pathogenesis of CCE was only considered to be an inflammatory response after embolism&#44; opposite proofs have also existed&#46; Recently&#44; there were two important studies which showed a significant correlation between allergic disease and atherosclerosis&#46; In the Bruneck study of 826 middle aged and elderly Italian subjects&#44; the risk for atherosclerosis development and progression increased significantly for 32 subjects with allergic disorders&#46; Furthermore&#44; serum IgE levels were significantly raised in subjects in whom atherosclerosis had developed or progressed&#46;<span class="elsevierStyleSup">2</span> In the ARMY study which took 141 male Austrian subjects aged 17 and 18 years&#44; the vascular intima-media thickness &#40;IMT&#41; measured by ultrasonography of the 34 subjects diagnosed as having allergic disease was higher than the healthy subjects&#46;<span class="elsevierStyleSup">2&#44;3</span> Although the exact mechanism is still not fully understood&#44; components of the allergic process such as leukotrienes and mast cells may be involved in atherogenesis&#46;<span class="elsevierStyleSup">2</span> Furthermore&#44; IgE has been proved to be able to promote atherogenesis in Apoe<span class="elsevierStyleSup">-&#47;-</span> mice&#46;<span class="elsevierStyleSup">4</span></p><p class="elsevierStylePara">There has not been a definite consensus of the treatment of CCE by now&#46;<span class="elsevierStyleSup">6&#44;7</span> Although the use of corticosteroid is still controversial&#44; our patient received only corticosteroid treatment without other above drugs and satisfactory results were obtained&#46; Previous reports indicated that Anticoagulant therapy&#44; which is generally essential in hemodialysis&#44; was harmful to patients with CCE because it was a potent risk factor for plaque rupture and cholesterol embolism&#46;<span class="elsevierStyleSup">8</span> Since the present patient was cured successfully with corticosteroid&#44; hemodialysis was avoided and the renal function kept stable to date&#46; So we think treatment with corticosteroid should be a recommended alternative for patients with CCE&#44; especially for patients who had obvious allergic conditions&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest<br></br>&#160;</span></p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript&#46;<span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><a href="grande&#47;11652&#95;108&#95;34154&#95;en&#95;f114&#46;jpg" class="elsevierStyleCrossRefs"><img src="11652_108_34154_en_f114.jpg" alt="The kidney biopsy and clinical course of the patient"></img></a></p><p class="elsevierStylePara">Figure 1&#46; The kidney biopsy and clinical course of the patient</p>"
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