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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span> Bone metabolism disorders in hemodialysed patients &#40;HD&#41; involve several humoral factors&#44; of which PTH plays the central role&#46; Leptin is usually found increased in renal failure and its link with bone metabolism&#160; has not been elucidated&#46; We investigated the BMD and bone metabolism&#160; in association with serum&#160; PTH&#44; 25OHD3 and leptin in HD patients&#46; <span class="elsevierStyleBold">Methods&#58; </span>We measured bone alkaline phosphatase &#40;bSAP&#41;&#44; cross linked N telopeptide of type 1 collagen &#40;NTx&#41;&#44; PTH&#44; 25OHD3 and leptin in 37 HD patients&#46; We also evaluated BMI and BMD in lumbar spine &#40;LS&#41; and in femoral neck &#40;FN&#41; by DXA&#46; Statistical evaluations were based on simple regression analysis&#46; <span class="elsevierStyleBold">Results&#58; </span>1&#41; Osteopenia was found in 32&#44;1&#37; in LS and 50&#37; in FN and osteoporosis in 14&#46;3&#37; and 21&#46;4&#37; of our patients&#44; respectively&#46; LS or FN Z score was not related&#160; to HD duration&#46; 2&#41; Bone markers&#44; PTH&#44; phosphorus and leptin levels were increased&#46; 3&#41; 25OHD3 was low and was not related to NTx&#44; bSAP or PTH&#46; 4&#41; PTH correlated with bone markers and Z score in LS and FN&#46; 5&#41; Leptin had no correlation with bone markers or Z score &#40;except BMI&#41;&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>In our hemodialysed patients bone metabolism markers were increased in relation with high serum&#160; PTH levels&#46; The observed high serum leptin was not associated with bone metabolism&#46; Additionally the duration of hemodialysis did not appear to affect bone density&#46;<span class="elsevierStyleBold"></span></p>"
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Densidad mineral y metabolismo óseo en pacientes en hemodiálisis. Correlación con la hormona paratifoidea, el 25(OH)D3 y la leptina
Bone mineral density and bone metabolism in hemodialysis patients. Correlation with PTH, 25OHD3 and leptin
A.. Polymerisa, K.. Doumouchtsisa, E.. Grapsab
a Second Division of Endocrinology, Alexandra Hospital, Athens, Greece,
b Renal Unit, Alexandra Hospital, Athens, Greece,
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Antecedentes&#58; </span>Los trastornos del metabolismo &#243;seo en pacientes en hemodi&#225;lisis &#40;HD&#41; implican varios factores humorales&#44; de los cuales la funci&#243;n central recae sobre la hormona paratiroidea&#46; Cuando hay insuficiencia renal normalmente se detectan niveles elevados de leptina y su relaci&#243;n con el metabolismo &#243;seo est&#225; a&#250;n por esclarecer&#46; Investigamos la densidad mineral &#243;sea &#40;DMO&#41; y el metabolismo &#243;seo en relaci&#243;n con la hormona paratiroidea s&#233;rica&#44; el 25&#40;OH&#41;D3 y la leptina en pacientes en HD&#46; <span class="elsevierStyleBold">M&#233;todos&#58; </span>Medimos la fosfatasa alcalina &#243;sea &#40;FAO&#41;&#44; el telop&#233;ptido N&#44; la hormona paratiroidea&#44; el 25&#40;OH&#41;D3 y la leptina en 37 pacientes en HD&#46; Asimismo&#44; evaluamos el IMC y la DMO en la columna lumbar &#40;CL&#41; y en el cuello femoral &#40;CF&#41; mediante DXA&#46; Las evaluaciones estad&#237;sticas se basaron en an&#225;lisis de regresi&#243;n simples&#46; Entrecruzamiento del telop&#233;ptido N del col&#225;geno &#243;seo tipo I&#46; <span class="elsevierStyleBold">Resultados&#58;</span> 1&#41; De nuestros pacientes&#44; el 32&#44;1&#37; presentaba osteopenia en CL y 50&#37; en CF y el 14&#44;3&#37; y el 21&#44;4&#37; osteoporosis&#44; respectivamente&#46; El puntaje Z en CL o CF no estaba relacionado con la duraci&#243;n de la HD&#46; 2&#41; Los marcadores &#243;seos&#44; la hormona paratiroidea&#44; y los niveles de f&#243;sforo y leptina se vieron incrementados&#46; 3&#41; El 25&#40;OH&#41;D3 era bajo y no estaba relacionado con el telop&#233;ptido N&#44; la FAO o la hormona paratiroidea&#46; 4&#41; La hormona paratiroidea estaba correlacionada con los marcadores &#243;seos y con el puntaje Z en CL y CF&#46; 5&#41; La leptina no presentaba correlaci&#243;n con los marcadores &#243;seos o con el puntaje Z &#40;con excepci&#243;n del IMC&#41;&#46; <span class="elsevierStyleBold">Conclusiones&#58; </span>En nuestros pacientes en hemodi&#225;lisis&#44; los marcadores del metabolismo &#243;seo se vieron incrementados en relaci&#243;n con los niveles elevados de hormona paratiroidea s&#233;rica&#46; La elevada leptina s&#233;rica observada no estaba asociada al metabolismo &#243;seo&#46; Adem&#225;s&#44; la duraci&#243;n de la hemodi&#225;lisis no pareci&#243; afectar a la densidad &#243;sea&#46;<br /><br /></p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58;</span> Bone metabolism disorders in hemodialysed patients &#40;HD&#41; involve several humoral factors&#44; of which PTH plays the central role&#46; Leptin is usually found increased in renal failure and its link with bone metabolism&#160; has not been elucidated&#46; We investigated the BMD and bone metabolism&#160; in association with serum&#160; PTH&#44; 25OHD3 and leptin in HD patients&#46; <span class="elsevierStyleBold">Methods&#58; </span>We measured bone alkaline phosphatase &#40;bSAP&#41;&#44; cross linked N telopeptide of type 1 collagen &#40;NTx&#41;&#44; PTH&#44; 25OHD3 and leptin in 37 HD patients&#46; We also evaluated BMI and BMD in lumbar spine &#40;LS&#41; and in femoral neck &#40;FN&#41; by DXA&#46; Statistical evaluations were based on simple regression analysis&#46; <span class="elsevierStyleBold">Results&#58; </span>1&#41; Osteopenia was found in 32&#44;1&#37; in LS and 50&#37; in FN and osteoporosis in 14&#46;3&#37; and 21&#46;4&#37; of our patients&#44; respectively&#46; LS or FN Z score was not related&#160; to HD duration&#46; 2&#41; Bone markers&#44; PTH&#44; phosphorus and leptin levels were increased&#46; 3&#41; 25OHD3 was low and was not related to NTx&#44; bSAP or PTH&#46; 4&#41; PTH correlated with bone markers and Z score in LS and FN&#46; 5&#41; Leptin had no correlation with bone markers or Z score &#40;except BMI&#41;&#46; <span class="elsevierStyleBold">Conclusions&#58; </span>In our hemodialysed patients bone metabolism markers were increased in relation with high serum&#160; PTH levels&#46; The observed high serum leptin was not associated with bone metabolism&#46; Additionally the duration of hemodialysis did not appear to affect bone density&#46;<span class="elsevierStyleBold"></span></p>"
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Información del artículo
ISSN: 02116995
Idioma original: Español
DOI:10.3265/Nefrologia.pre2011.Jul.10916
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