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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction&#58;</span> The development of intradialytic hypotension during hemodialysis &#40;HD&#41; in which fluid removal is the primary goal&#44; contributes to the excessive morbidity that is associated with the dialysis procedure&#46;&#160;<span class="elsevierStyleBold">Materials and Methods&#58;</span> In a double blinded clinical trial&#44; we compared the possible effect of intranasal DDAVP with intranasal distilled water as a placebo in prevention of intradialytic hypotension &#40;IDH&#41; in patients with known symptomatic IDH&#46; In the first month of the study&#44; nasal spray of distill water were administrated 30 minutes before all HD session &#40;Placebo Group&#44; Group 1&#41; and then after a 30-day washout period we were used intranasal DDAVP 30 minutes before HD session &#40;Vasopressin Group&#44; Group 2&#41;&#46; Blood pressure was measured just before HD&#44; two hours later and after termination of HD&#46; A hypotensive episode was defined as a decline of systolic blood pressure of more than 10mm Hg&#46;&#160;<span class="elsevierStyleBold">Results&#58;</span> In overall Seventeen patients &#40;nine men&#44; eight women&#59; mean age&#44; 47&#46;5 years&#41; with known symptomatic IDH were enrolled in the study&#46; The kind of dialysis membranes&#44; mean of blood flow rate&#44; dialyzate flow rate and ultrafiltration rate were the same in both groups&#46; Each group has 204 HD session &#40;17 &#42; 12&#41;&#46; Hypotensive episode occurred 18 times &#40;8&#46;82&#37;&#41; in vasopressin group compared with 125 times &#40;61&#46;27&#37;&#41; in placebo group and there was a significant association between them &#40;p&#61;0&#46;0001&#41;&#46; In addition mean arterial blood pressure in vasopressin group was 80&#46;77 and in placebo group was 73&#46;92 and also there was a significant association &#40;p&#61;0&#46;0001&#41;&#46; The mean Kt&#47;v in group 1 and 2 were 1&#46;29 and 1&#46;28 without any differences between them &#40;p&#61;0&#46;896&#41;&#46;&#160;<span class="elsevierStyleBold">Conclusion&#58;</span> These results indicate that Compared with placebo&#44; Vasopressin is significantly associated with a decreased incidence of intradialytic hypotension episodes during hemodialysis&#46;</p>"
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Efecto de la DDVAP intranasal en la prevención de la hipotensión durante la hemodiálisis
Effect of Intranasal DDAVP in Prevention of Hypotension during Hemodialysis
Seyed S. Beladi-Mousavia, Marzieh Beladi-Mousavib, Fatemeh Hayatia, Mehdi Talebzadeha
a Department of internal medicine, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran,
b Science and Research Branch, Department of Chemistry, Islamic Azad University, Omidiyeh, Iran,
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introducci&#243;n&#58;</span><span class="elsevierStyleBold"> </span>La aparici&#243;n de hipotensi&#243;n intradial&#237;tica durante la hemodi&#225;lisis &#40;HD&#41; en la que el objetivo principal es la eliminaci&#243;n de fluidos&#44; contribuye a una morbilidad excesiva que se asocia con la di&#225;lisis<span class="elsevierStyleBold">&#46; Materiales y m&#233;todos&#58;</span><span class="elsevierStyleBold"> </span>Mediante un ensayo cl&#237;nico doble ciego&#44; comparamos los posibles efectos de la DDAVP intranasal con los del agua destilada intranasal como placebo en la prevenci&#243;n de la hipotensi&#243;n intradial&#237;tica &#40;HID&#41; en pacientes con HID sintom&#225;tica diagnosticada&#46; Durante el primer mes del estudio&#44; la pulverizaci&#243;n nasal de agua destilada se realizaba 30 minutos antes de todas las sesiones de HD &#40;grupo de placebo&#44; grupo 1&#41; y luego&#44; tras un periodo de reposo de 30 d&#237;as&#44; utilizamos DDVAP intranasal 30 minutos antes de las sesiones de HD &#40;grupo vasopresina&#44; grupo 2&#41;&#46; La presi&#243;n arterial se med&#237;a justo antes de la HD&#44; dos horas despu&#233;s y una vez finalizada la HD&#46; Se defini&#243; como episodio de hipotensi&#243;n la ca&#237;da de la presi&#243;n arterial sist&#243;lica del m&#225;s de 10 mmHg&#46; <span class="elsevierStyleBold">Resultados&#58;</span><span class="elsevierStyleBold"> </span>Se incluy&#243; en el estudio un total de 17 pacientes &#40;nueve hombres y ocho mujeres de 47&#44;5 a&#241;os de edad media&#41; con HID sintom&#225;tica diagnosticada&#46; En ambos grupos&#44; el tipo de membranas de di&#225;lisis&#44; la media del flujo sangu&#237;neo&#44; la tasa del flujo dializado y la tasa de ultrafiltraci&#243;n eran los mismos&#46; Ambos grupos se sometieron a 204 sesiones de HD &#40;17 x 12&#41;&#46; Los episodios de hipotensi&#243;n sucedieron en 18 ocasiones &#40;8&#44;82&#37;&#41; en el grupo de vasopresina en comparaci&#243;n con las 125 ocasiones &#40;61&#44;27&#37;&#41; del grupo de placebo y hubo una relaci&#243;n significativa entre ellos &#40;p&#61;0&#44;0001&#41;&#46; Adem&#225;s&#44; la presi&#243;n arterial media en el grupo de vasopresina era de 80&#46;77 y en el grupo de placebo era de 73&#44;92 e igualmente se observ&#243; una asociaci&#243;n significativa &#40;p&#61;0&#44;0001&#41;&#46; La media Kt&#47;v en el grupo 1 y el 2 fue de 1&#44;29 y 1&#44;28 sin diferencias entre ellos &#40;p&#61;0&#44;896&#41;&#46; <span class="elsevierStyleBold">Conclusi&#243;n&#58;</span><span class="elsevierStyleBold"> </span>Estos resultados indican que&#44; en comparaci&#243;n con el placebo&#44; la vasopresina est&#225; relacionada de forma significativa con una menor incidencia de los episodios de hipotensi&#243;n intradial&#237;tica durante la hemodi&#225;lisis&#46;</p>"
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