se ha leído el artículo
array:21 [ "pii" => "X0211699511052458" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2011.Jun.10942" "estado" => "S300" "fechaPublicacion" => "2011-09-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2011;31:608-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3938 "formatos" => array:3 [ "EPUB" => 300 "HTML" => 3056 "PDF" => 582 ] ] "Traduccion" => array:1 [ "en" => array:17 [ "pii" => "X2013251411052455" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2011.Jun.10942" "estado" => "S300" "fechaPublicacion" => "2011-09-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2011;31:608-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3429 "formatos" => array:3 [ "EPUB" => 303 "HTML" => 2579 "PDF" => 547 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Cyclophosphamide-induced lupus flare?: the role of C4 and interferon-gamma in lupus flare" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "608" "paginaFinal" => "609" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S.J. Park, J.H. Kim, T.S. Ha, J.I. Shin" "autores" => array:4 [ 0 => array:2 [ "Iniciales" => "S.J." "apellidos" => "Park" ] 1 => array:2 [ "Iniciales" => "J.H." "apellidos" => "Kim" ] 2 => array:2 [ "Iniciales" => "T.S." "apellidos" => "Ha" ] 3 => array:2 [ "Iniciales" => "J.I." "apellidos" => "Shin" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X0211699511052458" "doi" => "10.3265/Nefrologia.pre2011.Jun.10942" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511052458?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411052455?idApp=UINPBA000064" "url" => "/20132514/0000003100000005/v0_201502091634/X2013251411052455/v0_201502091634/en/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X021169951105244X" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2011.Jul.11029" "estado" => "S300" "fechaPublicacion" => "2011-09-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2011;31:609-10" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 7985 "formatos" => array:3 [ "EPUB" => 263 "HTML" => 7187 "PDF" => 535 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Brote lúpico durante la inducción con ciclofosfamida en la nefropatía lúpica proliferativa difusa" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "609" "paginaFinal" => "610" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cyclophosphamide-induced lupus flare in diffuse proliferative lupus nephropathy" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Heras, A. Saiz, M.J. Fernández-Reyes, R. Sánchez, P. Zurita, C. Urrego" "autores" => array:6 [ 0 => array:2 [ "Iniciales" => "M." "apellidos" => "Heras" ] 1 => array:2 [ "Iniciales" => "A." "apellidos" => "Saiz" ] 2 => array:2 [ "Iniciales" => "M.J." "apellidos" => "Fernández-Reyes" ] 3 => array:2 [ "Iniciales" => "R." "apellidos" => "Sánchez" ] 4 => array:2 [ "Iniciales" => "P." "apellidos" => "Zurita" ] 5 => array:2 [ "Iniciales" => "C." "apellidos" => "Urrego" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251411052447" "doi" => "10.3265/Nefrologia.pre2011.Jul.11029" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411052447?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169951105244X?idApp=UINPBA000064" "url" => "/02116995/0000003100000005/v0_201502091408/X021169951105244X/v0_201502091409/es/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X0211699511052466" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2011.Aug.11119" "estado" => "S300" "fechaPublicacion" => "2011-09-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2011;31:607-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5697 "formatos" => array:3 [ "EPUB" => 288 "HTML" => 4910 "PDF" => 499 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Respuesta al comentario sobre el Manejo de la infección por el virus de la hepatitis C en la enfermedad renal crónica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "607" "paginaFinal" => "608" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Response to the comment made on Treatment of HCV infection in chronic kidney disease" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rebeca García Agudo, R. García Agudo, Sami Aoufi Rabih, S. Aoufi Rabih" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Rebeca" "apellidos" => "García Agudo" ] 1 => array:2 [ "Iniciales" => "R." "apellidos" => "García Agudo" ] 2 => array:2 [ "nombre" => "Sami" "apellidos" => "Aoufi Rabih" ] 3 => array:2 [ "Iniciales" => "S." "apellidos" => "Aoufi Rabih" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251411052463" "doi" => "10.3265/Nefrologia.pre2011.Aug.11119" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251411052463?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511052466?idApp=UINPBA000064" "url" => "/02116995/0000003100000005/v0_201502091408/X0211699511052466/v0_201502091409/es/main.assets" ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Cyclophosphamide-induced lupus flare?: the role of C4 and interferon-gamma in lupus flare" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "608" "paginaFinal" => "609" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "S.J. Park, J.H. Kim, T.S. Ha, J.I. Shin" "autores" => array:4 [ 0 => array:3 [ "Iniciales" => "S.J." "apellidos" => "Park" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "J.H." "apellidos" => "Kim" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "Iniciales" => "T.S." "apellidos" => "Ha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 3 => array:4 [ "Iniciales" => "J.I." "apellidos" => "Shin" "email" => array:1 [ 0 => "shinji@yuhs.ac" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Pediatrics Department, Ajou University School of Medicine, Suwon, Republic of Korea, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Pediatrics Department, Yonsei University College of Medicine, Seoul, Republic of Korea, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Pediatrics Department, Chungbuk National University College of Medicine, Cheongju, Republic of Korea, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cyclophosphamide-induced lupus flare?: the role of C4 and interferon-gamma in lupus flare" ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor:</span></p><p class="elsevierStylePara">We read with great interest the contribution by Heras, et al.<span class="elsevierStyleSup">1</span>. They reported a significant case that seemed not to respond to intravenous (IV) cyclophosphamide (CPM) induction treatment at 1 g but to respond to increased CPM dose to 1.5 g. Reading the case report, we wondered whether CPM certainly induced the lupus flare or other mechanisms were involved in the pathogenesis. They speculated that the lupus flare might have been due to the initial underdosing of cyclophosphamide. This explanation is plausible, but we would like to say that lupus flares can occur during or after stopping CPM treatment, suggesting the possible pathomechanisms of lupus flare.</p><p class="elsevierStylePara">In the immunological test after the first treatment of IV CPM, the patient had increased C3 level, but C4 was decreased. According to a previous study by Ho, et al.<span class="elsevierStyleSup">2</span>, a decrease in C4 was associated with a concurrent increase in renal disease activity (p = 0.02). A decrease in C4 was especially associated with concurrent decreases in the hematocrit levels (p = 0.009), and previous increases in C3 were also associated with a higher frequency of decrease in platelet counts (p = 0.02). These data show that the renal and hematologic systemic lupus erythematosus (SLE) activity and flares are strongly associated with decreased C4.</p><p class="elsevierStylePara">Recently, Finke, et al.<span class="elsevierStyleSup">3</span> demonstrated that complement C4-deficient mice result in elevated intravascular levels of apoptotic DNA, targeted to the splenic marginal zone where it accumulates and induces type I interferon-gamma (IFN-γ). Type I IFN-γ is important for the initiation and potentiation of SLE activity and correlated with the renal disease and the presence of cutaneous manifestations<span class="elsevierStyleSup">4</span>.</p><p class="elsevierStylePara">Therefore, we suggest that CPM is not an inducer but an inhibitor of lupus flare, and decreases in C4 and increased type I IFN-γ might play the central role in the development of lupus activity and flares. However, further studies are necessary to elucidate the exact molecular roles of complement deficiency and elevated levels of IFN-γ. The potential therapeutic antibodies directed to either type I IFN-γ or IFN α chain of the receptor 1 (IFNAR1)/IFNAR2 should also be further evaluated in the future.</p>" "pdfFichero" => "P1-E524-S3252-A10942.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Heras M, Saiz A, Fernández-Reyes MJ, Sánchez R, Zurita P, Urrego C. Cyclophosphamide-induced lupus flare in diffuse proliferative lupus nephropathy. Nefrologia 2011;22;31." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ho A, Barr SG, Magder LS, Petri M. A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:2350-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11665976" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Finke D, Randers K, Hoerster R, Hennig H, Zawatzky R, Marion T, et al. Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus. Eur J Immunol 2007;37:1702-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17506029" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Dall'era MC, Cardarelli PM, Preston BT, Witte A, Davis JC Jr. Type I interferon correlates with serological and clinical manifestations of SLE. Ann Rheum Dis 2005;64:1692-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15843451" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/0000003100000005/v0_201502091408/X0211699511052458/v0_201502091409/en/main.assets" "Apartado" => array:4 [ "identificador" => "35348" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas al Director - Comentarios a artículos publicados" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003100000005/v0_201502091408/X0211699511052458/v0_201502091409/en/P1-E524-S3252-A10942.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699511052458?idApp=UINPBA000064" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 6 | 11 | 17 |
2024 Octubre | 47 | 40 | 87 |
2024 Septiembre | 45 | 30 | 75 |
2024 Agosto | 57 | 60 | 117 |
2024 Julio | 48 | 25 | 73 |
2024 Junio | 51 | 27 | 78 |
2024 Mayo | 65 | 37 | 102 |
2024 Abril | 51 | 33 | 84 |
2024 Marzo | 52 | 22 | 74 |
2024 Febrero | 36 | 41 | 77 |
2024 Enero | 36 | 18 | 54 |
2023 Diciembre | 24 | 20 | 44 |
2023 Noviembre | 29 | 31 | 60 |
2023 Octubre | 33 | 28 | 61 |
2023 Septiembre | 34 | 31 | 65 |
2023 Agosto | 23 | 27 | 50 |
2023 Julio | 56 | 29 | 85 |
2023 Junio | 35 | 24 | 59 |
2023 Mayo | 37 | 33 | 70 |
2023 Abril | 24 | 16 | 40 |
2023 Marzo | 21 | 21 | 42 |
2023 Febrero | 24 | 29 | 53 |
2023 Enero | 26 | 26 | 52 |
2022 Diciembre | 35 | 42 | 77 |
2022 Noviembre | 34 | 28 | 62 |
2022 Octubre | 44 | 59 | 103 |
2022 Septiembre | 42 | 33 | 75 |
2022 Agosto | 34 | 54 | 88 |
2022 Julio | 34 | 50 | 84 |
2022 Junio | 30 | 38 | 68 |
2022 Mayo | 31 | 44 | 75 |
2022 Abril | 42 | 51 | 93 |
2022 Marzo | 39 | 60 | 99 |
2022 Febrero | 33 | 50 | 83 |
2022 Enero | 35 | 38 | 73 |
2021 Diciembre | 35 | 42 | 77 |
2021 Noviembre | 26 | 33 | 59 |
2021 Octubre | 32 | 45 | 77 |
2021 Septiembre | 31 | 39 | 70 |
2021 Agosto | 24 | 42 | 66 |
2021 Julio | 33 | 24 | 57 |
2021 Junio | 20 | 25 | 45 |
2021 Mayo | 31 | 42 | 73 |
2021 Abril | 44 | 35 | 79 |
2021 Marzo | 35 | 27 | 62 |
2021 Febrero | 38 | 15 | 53 |
2021 Enero | 18 | 22 | 40 |
2020 Diciembre | 18 | 15 | 33 |
2020 Noviembre | 23 | 16 | 39 |
2020 Octubre | 11 | 14 | 25 |
2020 Septiembre | 22 | 4 | 26 |
2020 Agosto | 35 | 14 | 49 |
2020 Julio | 36 | 10 | 46 |
2020 Junio | 23 | 15 | 38 |
2020 Mayo | 45 | 14 | 59 |
2020 Abril | 44 | 22 | 66 |
2020 Marzo | 30 | 14 | 44 |
2020 Febrero | 27 | 17 | 44 |
2020 Enero | 30 | 20 | 50 |
2019 Diciembre | 27 | 22 | 49 |
2019 Noviembre | 29 | 16 | 45 |
2019 Octubre | 10 | 11 | 21 |
2019 Septiembre | 21 | 22 | 43 |
2019 Agosto | 9 | 17 | 26 |
2019 Julio | 25 | 25 | 50 |
2019 Junio | 19 | 11 | 30 |
2019 Mayo | 15 | 12 | 27 |
2019 Abril | 42 | 38 | 80 |
2019 Marzo | 24 | 16 | 40 |
2019 Febrero | 15 | 13 | 28 |
2019 Enero | 30 | 25 | 55 |
2018 Diciembre | 74 | 41 | 115 |
2018 Noviembre | 178 | 25 | 203 |
2018 Octubre | 98 | 11 | 109 |
2018 Septiembre | 66 | 16 | 82 |
2018 Agosto | 36 | 24 | 60 |
2018 Julio | 51 | 14 | 65 |
2018 Junio | 46 | 15 | 61 |
2018 Mayo | 59 | 12 | 71 |
2018 Abril | 56 | 14 | 70 |
2018 Marzo | 79 | 9 | 88 |
2018 Febrero | 77 | 7 | 84 |
2018 Enero | 50 | 12 | 62 |
2017 Diciembre | 56 | 8 | 64 |
2017 Noviembre | 32 | 5 | 37 |
2017 Octubre | 30 | 4 | 34 |
2017 Septiembre | 33 | 10 | 43 |
2017 Agosto | 29 | 9 | 38 |
2017 Julio | 42 | 12 | 54 |
2017 Junio | 32 | 8 | 40 |
2017 Mayo | 41 | 11 | 52 |
2017 Abril | 31 | 5 | 36 |
2017 Marzo | 20 | 4 | 24 |
2017 Febrero | 13 | 7 | 20 |
2017 Enero | 17 | 9 | 26 |
2016 Diciembre | 44 | 7 | 51 |
2016 Noviembre | 28 | 8 | 36 |
2016 Octubre | 67 | 8 | 75 |
2016 Septiembre | 92 | 3 | 95 |
2016 Agosto | 166 | 4 | 170 |
2016 Julio | 101 | 3 | 104 |
2016 Junio | 116 | 0 | 116 |
2016 Mayo | 115 | 0 | 115 |
2016 Abril | 72 | 0 | 72 |
2016 Marzo | 59 | 0 | 59 |
2016 Febrero | 82 | 0 | 82 |
2016 Enero | 68 | 0 | 68 |
2015 Diciembre | 98 | 0 | 98 |
2015 Noviembre | 68 | 0 | 68 |
2015 Octubre | 71 | 0 | 71 |
2015 Septiembre | 39 | 0 | 39 |
2015 Agosto | 56 | 0 | 56 |
2015 Julio | 65 | 0 | 65 |
2015 Junio | 35 | 0 | 35 |
2015 Mayo | 50 | 0 | 50 |
2015 Abril | 8 | 0 | 8 |