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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Introducci&#243;n&#58;</span> El objetivo del presente estudio ha sido evaluar la relaci&#243;n entre la leptina s&#233;rica y el cociente leptina&#47;&#237;ndice de masa corporal &#40;IMC&#41; con la enfermedad cardiovascular &#40;ECV&#41; prevalente y su influencia en la mortalidad global y en la mortalidad por ECV en pacientes en hemodi&#225;lisis &#40;HD&#41;&#46; <span class="elsevierStyleBold">M&#233;todos&#58; </span>Se estudiaron 118 pacientes estables en HD &#40;50 mujeres&#44; edad mediana &#91;recorrido intercuart&#237;lico&#93;&#44; 65&#44;1 &#91;54&#44;7-72&#44;2&#93; a&#241;os&#41;&#46; En todos los pacientes se cuantific&#243; la concentraci&#243;n basal de leptina&#46; La relaci&#243;n entre leptina y la mortalidad se evalu&#243; mediante an&#225;lisis de supervivencia y an&#225;lisis de regresi&#243;n de Cox&#46; <span class="elsevierStyleBold">Resultados&#58;</span> El cociente leptina&#47;IMC fue similar en pacientes con y sin ECV prevalente &#40;0&#44;65 &#91;0&#44;29-2&#44;23&#93; frente a 0&#44;68 &#91;0&#44;29-1&#44;49&#93; ng&#183;m<span class="elsevierStyleSup">2</span>&#47;ml&#183;kg&#44; respectivamente&#44; NS&#41;&#46; El an&#225;lisis de regresi&#243;n log&#237;stica mostr&#243; que no exist&#237;a una asociaci&#243;n independiente entre el cociente leptina&#47;IMC y la enfermedad cardiovascular prevalente&#46; Durante el seguimiento 52 pacientes fallecieron&#160;&#40;44&#44;1&#37;&#41;&#46; La ECV fue causa de muerte en 27 de 52 pacientes fallecidos &#40;51&#44;9&#37;&#41;&#46; El an&#225;lisis de supervivencia y el an&#225;lisis multivariante de Cox mostraron que no hubo relaci&#243;n significativa entre los niveles de leptina o el cociente leptina&#47;IMC y la mortalidad global o por causa de ECV&#46; <span class="elsevierStyleBold">Conclusi&#243;n&#58;</span> Estos resultados no apoyan la hip&#243;tesis de que&#44; en pacientes estables en HD&#44; las concentraciones de leptina y el cociente leptina&#47;IMC est&#233;n relacionados con la ECV prevalente&#46; M&#225;s a&#250;n&#44; el cociente leptina&#47;IMC no parece ser un factor de riesgo de mortalidad en estos pacientes&#46;</span></p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58; </span>We aimed to evaluate the relationship between serum leptin and the leptin&#47;body mass index &#40;BMI&#41; ratio with prevalent cardiovascular disease &#40;CVD&#41;&#44; and their influence on all-cause and CVD-related mortality in patients on hemodialysis &#40;HD&#41;&#46; <span class="elsevierStyleBold">Methods&#58;</span> 118 stable HD patients &#40;50 women&#44; median &#91;interquartile range&#93; age&#44; 65&#46;1 &#91;54&#46;7-72&#46;2&#93; years&#41; were studied&#46; All patients had baseline measurement of serum leptin concentrations&#46; Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis&#46;<span class="elsevierStyleBold"> Results&#58; </span>The leptin&#47;BMI ratio was similar in patients with and without CVD at baseline &#40;0&#46;65 &#91;0&#46;29-2&#46;23&#93; vs&#46; 0&#46;68 &#91;0&#46;29-1&#46;49&#93; ng&#183;m<span class="elsevierStyleSup">2</span>&#47;ml&#183;kg&#44; respectively&#44; NS&#41;&#46; Multiple logistic regression analysis showed that there was not an independent association between leptin&#47;BMI ratio and prevalent CVD&#46; During the follow-up time&#44; 52 &#40;44&#46;1&#37;&#41; patients died&#46; CVD was the cause of death in 27 out of 52 &#40;51&#46;9&#37;&#41; deceased patients&#46; Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin&#47;BMI ratio and all-cause and CVD-related mortality&#46; <span class="elsevierStyleBold">Conclusion&#58;</span> These results do not support that&#44; in stable HD patients&#44; serum leptin concentrations and the leptin&#47;BMI ratio are related with prevalent CVD&#46; Leptin&#47;BMI ratio seems not to be a risk factor for mortality in these patients&#46;</p>"
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                  "referenciaCompleta" => "Heimbürger O, Lönnqvist F, Danielsson A, Nordenström J, Stenvinkel P. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 1997;8:1423-30.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/9294834" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Bossola M, Muscaritoli M, Valenza V, Panocchia N, Tazza L, Cascino A, et al. Anorexia and serum leptin levels in hemodialysis patients. Nephron Clin Pract 2004;97:c76-82.\u{A0} <a href="http://www.ncbi.nlm.nih.gov/pubmed/15292683" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "12.\u{A0}Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/8532024" target="_blank">[Pubmed]</a>"
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                0 => array:3 [
                  "referenciaCompleta" => "13.\u{A0}Eikelis N, Lambert G, Wiesner G, Kaye D, Schlaich M, Morris M, et al. Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function. Am J Physiol Endocrinol Metab 2004;286:E744-52.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/14722031" target="_blank">[Pubmed]</a>"
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                0 => array:3 [
                  "referenciaCompleta" => "14.\u{A0}Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, et al. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab 2004;89:3872-8.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/15292320" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "15.\u{A0}Singhal A, Farooqi IS, Cole TJ, O¿Rahilly S, Fewtrell M, Kattenhorn M, et al. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002;106:1919-24.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/12370213" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "25.\u{A0}Iglesias P, Díez JJ, Fernández-Reyes MJ, Bajo MA, Aguilera A, Méndez J, et al. Effects of short-term recombinant human growth hormone therapy on plasma leptin concentrations in dialysis patients. Nephrol Dial Transplant 2002;17:260-4.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/11812876" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "26.\u{A0}Aquilera A, Bajo MA, Rebollo F, Díez JJ, Díaz C, Paiva A, et al. Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. Adv Perit Dial 2002;18:212-7.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/12402621" target="_blank">[Pubmed]</a>"
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Relación entre leptina y mortalidad global y cardiovascular en pacientes en hemodiálisis
Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients
, Juan José Díezb, Maurizio Bossolac, María José Fernández-Reyesd, Enrico Di Stasioc, Luigi Tazzac, Giovanna Lucianic, Rosa Codoceoe, Pedro Iglesiasb, Astrid Rodríguezd, Elena Gonzálezf, Rafael Selgasf
b Endocrinología, Hospital Ramón y Cajal, Madrid, Madrid, España,
c Servizio Emodialisi, Università Cattolica del Sacro Cuore, Roma, Italia,
d Nefrología, Hospital General de Segovia, Segovia, Segovia, España,
e Bioquímica, Hospital La Paz, Madrid, Madrid, España,
f Nefrología, Hospital La Paz, Madrid, Madrid, España,
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        "titulo" => "Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">Introducci&#243;n&#58;</span> El objetivo del presente estudio ha sido evaluar la relaci&#243;n entre la leptina s&#233;rica y el cociente leptina&#47;&#237;ndice de masa corporal &#40;IMC&#41; con la enfermedad cardiovascular &#40;ECV&#41; prevalente y su influencia en la mortalidad global y en la mortalidad por ECV en pacientes en hemodi&#225;lisis &#40;HD&#41;&#46; <span class="elsevierStyleBold">M&#233;todos&#58; </span>Se estudiaron 118 pacientes estables en HD &#40;50 mujeres&#44; edad mediana &#91;recorrido intercuart&#237;lico&#93;&#44; 65&#44;1 &#91;54&#44;7-72&#44;2&#93; a&#241;os&#41;&#46; En todos los pacientes se cuantific&#243; la concentraci&#243;n basal de leptina&#46; La relaci&#243;n entre leptina y la mortalidad se evalu&#243; mediante an&#225;lisis de supervivencia y an&#225;lisis de regresi&#243;n de Cox&#46; <span class="elsevierStyleBold">Resultados&#58;</span> El cociente leptina&#47;IMC fue similar en pacientes con y sin ECV prevalente &#40;0&#44;65 &#91;0&#44;29-2&#44;23&#93; frente a 0&#44;68 &#91;0&#44;29-1&#44;49&#93; ng&#183;m<span class="elsevierStyleSup">2</span>&#47;ml&#183;kg&#44; respectivamente&#44; NS&#41;&#46; El an&#225;lisis de regresi&#243;n log&#237;stica mostr&#243; que no exist&#237;a una asociaci&#243;n independiente entre el cociente leptina&#47;IMC y la enfermedad cardiovascular prevalente&#46; Durante el seguimiento 52 pacientes fallecieron&#160;&#40;44&#44;1&#37;&#41;&#46; La ECV fue causa de muerte en 27 de 52 pacientes fallecidos &#40;51&#44;9&#37;&#41;&#46; El an&#225;lisis de supervivencia y el an&#225;lisis multivariante de Cox mostraron que no hubo relaci&#243;n significativa entre los niveles de leptina o el cociente leptina&#47;IMC y la mortalidad global o por causa de ECV&#46; <span class="elsevierStyleBold">Conclusi&#243;n&#58;</span> Estos resultados no apoyan la hip&#243;tesis de que&#44; en pacientes estables en HD&#44; las concentraciones de leptina y el cociente leptina&#47;IMC est&#233;n relacionados con la ECV prevalente&#46; M&#225;s a&#250;n&#44; el cociente leptina&#47;IMC no parece ser un factor de riesgo de mortalidad en estos pacientes&#46;</span></p>"
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        "resumen" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Background&#58; </span>We aimed to evaluate the relationship between serum leptin and the leptin&#47;body mass index &#40;BMI&#41; ratio with prevalent cardiovascular disease &#40;CVD&#41;&#44; and their influence on all-cause and CVD-related mortality in patients on hemodialysis &#40;HD&#41;&#46; <span class="elsevierStyleBold">Methods&#58;</span> 118 stable HD patients &#40;50 women&#44; median &#91;interquartile range&#93; age&#44; 65&#46;1 &#91;54&#46;7-72&#46;2&#93; years&#41; were studied&#46; All patients had baseline measurement of serum leptin concentrations&#46; Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis&#46;<span class="elsevierStyleBold"> Results&#58; </span>The leptin&#47;BMI ratio was similar in patients with and without CVD at baseline &#40;0&#46;65 &#91;0&#46;29-2&#46;23&#93; vs&#46; 0&#46;68 &#91;0&#46;29-1&#46;49&#93; ng&#183;m<span class="elsevierStyleSup">2</span>&#47;ml&#183;kg&#44; respectively&#44; NS&#41;&#46; Multiple logistic regression analysis showed that there was not an independent association between leptin&#47;BMI ratio and prevalent CVD&#46; During the follow-up time&#44; 52 &#40;44&#46;1&#37;&#41; patients died&#46; CVD was the cause of death in 27 out of 52 &#40;51&#46;9&#37;&#41; deceased patients&#46; Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin&#47;BMI ratio and all-cause and CVD-related mortality&#46; <span class="elsevierStyleBold">Conclusion&#58;</span> These results do not support that&#44; in stable HD patients&#44; serum leptin concentrations and the leptin&#47;BMI ratio are related with prevalent CVD&#46; Leptin&#47;BMI ratio seems not to be a risk factor for mortality in these patients&#46;</p>"
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                  "referenciaCompleta" => "26.\u{A0}Aquilera A, Bajo MA, Rebollo F, Díez JJ, Díaz C, Paiva A, et al. Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients. Adv Perit Dial 2002;18:212-7.  <a href="http://www.ncbi.nlm.nih.gov/pubmed/12402621" target="_blank">[Pubmed]</a>"
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Información del artículo
ISSN: 02116995
Idioma original: Español
DOI:10.3265/Nefrologia.pre2010.Dec.10629
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