Hemofagocitosis asociada con el lupus: caso clínico
Acute lupus hemophagocytic syndrome: report of a case
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"apellidos" => "Carreira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Nephrology, Centro Hospitalar de Coimbra, Coimbra, Portugal, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Department Hematology, Centro Hospitalar de Coimbra, Coimbra, Portugal, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Acute lupus hemophagocytic syndrome: report of a case" ] ] "pdfFichero" => "P1-E47-S1883-A10121.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec431278" "palabras" => array:1 [ 0 => "Hemofagocitosis" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec431280" "palabras" => array:1 [ 0 => "Lupus eritematoso sistémico" ] ] ] "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec431279" "palabras" => array:1 [ 0 => "Hemophagocytic síndrome" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec431281" "palabras" => array:1 [ 0 => "Systemic lupus erythematosus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "La hemofagocitosis es un cuadro clínico caracterizado por la activación de los macrófagos y histiocitos, con intensa actividad fagocítica en la médula ósea e otras localizaciones del sistema reticuloendotelial, lo que provoca la fagocitosis de los eritrocitos, leucocitos, plaquetas y sus precursores. Su presencia puede estar asociada con infecciones, neoplasias, enfermedades autoinmunitarias, drogas y una variedad de otras condiciones médicas. En este caso clínico, presentamos a una mujer de 36 años, previamente sana, que desarrolló hemofagocitosis, al mismo tiempo que completó los criterios de diagnóstico de lupus eritematoso sistémico. La hemofagocitosis asociada con el lupus es una entidad rara, potencialmente mortal, de diagnóstico diferencial complicado y, que requiere una intervención terapéutica urgente. Hay muy pocos casos comunicados en la literatura, y es necesaria una mejor comprensión de los aspectos clínicos, causas, fisiopatología, criterios de diagnóstico y tratamiento de este síndrome." ] "en" => array:1 [ "resumen" => "<p class="elsevierStylePara">Hemophagocytic Syndrome is a clinical condition characterized by the activation of either macrophages or histiocytes with a prominent hemophagocytosis feature in the bone marrow and other reticuloendothelial systems. It leads to the phagocytosis of erythrocytes, leukocytes, platelets and their precursors. The presence of hemophagocytosis can be associated to infections, malignancies, autoimmune diseases, drugs and a variety of other medical conditions. We report a case of a previously healthy 36 year-old woman that developed hemophagocytosis at the same time that fulfilled diagnostic criteria for systemic lupus erythematosus. Lupus related hemophagocytic syndrome is a rare and potentially fatal entity. It offers significant differential diagnosis challenges and requires urgent therapeutic intervention. There are only few cases reported in the literature. However, much is still needed in order to better understand its causes, all the immunopathogenic mechanisms, as well as its clinical and therapeutic aspects.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Imashuku S. Advances in the management of hemophagocytic lymphohistiocytosis. Int J Hematol. 2000;72:1-11. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10979202" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Papo T, Andre MH, Amoura Z, et al. The spectrum of reactive hemophagocytic syndrome in systemic lupus erythematosus. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 7 | 13 |
| 2024 Octubre | 60 | 50 | 110 |
| 2024 Septiembre | 87 | 47 | 134 |
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| 2023 Noviembre | 187 | 48 | 235 |
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| 2023 Septiembre | 115 | 36 | 151 |
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| 2023 Julio | 181 | 39 | 220 |
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| 2023 Enero | 129 | 36 | 165 |
| 2022 Diciembre | 119 | 52 | 171 |
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| 2022 Septiembre | 120 | 46 | 166 |
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| 2022 Febrero | 77 | 47 | 124 |
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| 2021 Diciembre | 47 | 69 | 116 |
| 2021 Noviembre | 55 | 42 | 97 |
| 2021 Octubre | 65 | 66 | 131 |
| 2021 Septiembre | 62 | 46 | 108 |
| 2021 Agosto | 74 | 43 | 117 |
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| 2021 Febrero | 56 | 29 | 85 |
| 2021 Enero | 52 | 22 | 74 |
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| 2020 Octubre | 68 | 9 | 77 |
| 2020 Septiembre | 65 | 11 | 76 |
| 2020 Agosto | 53 | 14 | 67 |
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| 2020 Marzo | 42 | 31 | 73 |
| 2020 Febrero | 56 | 18 | 74 |
| 2020 Enero | 44 | 26 | 70 |
| 2019 Diciembre | 42 | 27 | 69 |
| 2019 Noviembre | 45 | 20 | 65 |
| 2019 Octubre | 39 | 25 | 64 |
| 2019 Septiembre | 52 | 35 | 87 |
| 2019 Agosto | 42 | 23 | 65 |
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| 2018 Diciembre | 64 | 47 | 111 |
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| 2018 Octubre | 60 | 40 | 100 |
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| 2018 Agosto | 41 | 18 | 59 |
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| 2018 Junio | 39 | 19 | 58 |
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| 2018 Marzo | 41 | 13 | 54 |
| 2018 Febrero | 22 | 11 | 33 |
| 2018 Enero | 31 | 8 | 39 |
| 2017 Diciembre | 38 | 18 | 56 |
| 2017 Noviembre | 22 | 13 | 35 |
| 2017 Octubre | 27 | 10 | 37 |
| 2017 Septiembre | 40 | 21 | 61 |
| 2017 Agosto | 49 | 11 | 60 |
| 2017 Julio | 46 | 15 | 61 |
| 2017 Junio | 48 | 15 | 63 |
| 2017 Mayo | 50 | 15 | 65 |
| 2017 Abril | 33 | 9 | 42 |
| 2017 Marzo | 29 | 21 | 50 |
| 2017 Febrero | 24 | 8 | 32 |
| 2017 Enero | 14 | 18 | 32 |
| 2016 Diciembre | 71 | 5 | 76 |
| 2016 Noviembre | 78 | 12 | 90 |
| 2016 Octubre | 110 | 16 | 126 |
| 2016 Septiembre | 159 | 13 | 172 |
| 2016 Agosto | 222 | 7 | 229 |
| 2016 Julio | 184 | 11 | 195 |
| 2016 Junio | 152 | 0 | 152 |
| 2016 Mayo | 187 | 0 | 187 |
| 2016 Abril | 115 | 0 | 115 |
| 2016 Marzo | 114 | 0 | 114 |
| 2016 Febrero | 119 | 0 | 119 |
| 2016 Enero | 133 | 0 | 133 |
| 2015 Diciembre | 130 | 0 | 130 |
| 2015 Noviembre | 105 | 0 | 105 |
| 2015 Octubre | 103 | 0 | 103 |
| 2015 Septiembre | 109 | 0 | 109 |
| 2015 Agosto | 74 | 0 | 74 |
| 2015 Julio | 83 | 0 | 83 |
| 2015 Junio | 43 | 0 | 43 |
| 2015 Mayo | 98 | 0 | 98 |
| 2015 Abril | 27 | 0 | 27 |
| 2015 Febrero | 3457 | 0 | 3457 |
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