array:19 [
  "pii" => "X0211699505018440"
  "issn" => "02116995"
  "estado" => "S300"
  "fechaPublicacion" => "2005-08-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2005;25:407-11"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4632
    "formatos" => array:3 [
      "EPUB" => 254
      "HTML" => 3772
      "PDF" => 606
    ]
  ]
  "itemSiguiente" => array:15 [
    "pii" => "X0211699505018612"
    "issn" => "02116995"
    "estado" => "S300"
    "fechaPublicacion" => "2005-08-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2005;25:407-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10082
      "formatos" => array:3 [
        "EPUB" => 252
        "HTML" => 8533
        "PDF" => 1297
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Catéteres de tesio permanentes para realización de hemodiálisis crónica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "407"
          "paginaFinal" => "411"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018612?idApp=UINPBA000064"
    "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018612/v0_201502091335/es/main.assets"
  ]
  "itemAnterior" => array:15 [
    "pii" => "X0211699505018459"
    "issn" => "02116995"
    "estado" => "S300"
    "fechaPublicacion" => "2005-08-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2005;25:399-406"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5479
      "formatos" => array:3 [
        "EPUB" => 256
        "HTML" => 4546
        "PDF" => 677
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Incidence and risk factors for non traumatic lower extremity amputation inhemodialysis patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "399"
          "paginaFinal" => "406"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. C. Sánchez Perales, M. J. García Cortés, F. J. Borrego Utiel, G. Viedma, J. M. Gil, P. Pérez del Barrio, J. Borrego Hinojosa, A. Liébana, V. Pérez"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "M. C. Sánchez Perales, M. J. García Cortés, F. J. Borrego Utiel, G. Viedma, J. M. Gil, P. Pérez del Barrio, J. Borrego Hinojosa, A. Liébana, V. Pérez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018459?idApp=UINPBA000064"
    "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018459/v0_201502091335/en/main.assets"
  ]
  "en" => array:8 [
    "idiomaDefecto" => true
    "titulo" => "Tesio catheters for long-term hemodialysis: our experience in a comarcal hospital"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "407"
        "paginaFinal" => "411"
      ]
    ]
    "autores" => array:1 [
      0 => array:2 [
        "autoresLista" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
        "autores" => array:1 [
          0 => array:1 [
            "nombre" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
          ]
        ]
      ]
    ]
    "textoCompleto" => "NEFROLOGÍA. Volumen 25. Número 4. 2005 Permanent Tesio's catheters for chronic hemodialysis: our experience at a regional hospital R. Álvarez Navascués, L. Quiñones and J. Guerediaga Nephrology Department. San Agustín Hospital. Avilés. Asturias. SUMMARY Introduction: Good vascular access remains the cornerstone of effective hemodialysis treatment. The Tesio catheters has been proposed to be a reliable source of vascular access for the dialysis patients. Subjects and methods: We examined all Tesio catheters inserted over a 3-year period in our hospital. We obtained age, sex, dialysis duration, original nephropaty, vascular access history, complications, dialysis parameters, catheter function duration, confort level for patients and nurses, and death in all our cases. Results: 33 catheters were inserted in 30 patients, 14 male and 16 female. Age 73,92 ± 9,22 years. Dialysis duration, 25,64 ± 53,45 months. Diabetic nephropaty 26,66%, NAE 40%, others 33,33%. First vascular access in 13 patients (43,33%), one previously fistula, 5 patients (16,66%), and more of one FAV, 12 patients (40%). We observed two bleeding cases, eight parcial trombosis, one total trombosis (non-function), six tunneled infection and two systemic infection. Only 3 catheters were removal. We obteined good dialysis parameters. Confort state for patients and nurses were satisfactory. Death 12 patients. Catheter function at the moment of study 16,76 ± 12,99 months. Conclusions: We conclued that Tesio catheters can provide excellent long-term vascular access for hemodialysis patients, especially in the older people and with some previous failure fistulas, with low complication rates and acceptable dialysis parameters and tolerance. However, the arteriovenous fistula remains the gold standard for long-term hemodialysis access. Key words: Permanent Tesio catheter. Comarcal Hospital. Correspondence: Dr. Rafael Álvarez Navascués Servicio de Nefrología Hospital San Agustín Camino de los Heros, 4 33400 Avilés (Asturias) 407 R. ÁLVAREZ NAVASCUÉS y cols. CATÉTERES DE TESIO PERMANENTES PARA REALIZACIÓN DE HEMODIÁLISIS CRÓNICA: NUESTRA EXPERIENCIA EN UN HOSPITAL COMARCAL RESUMEN Introducción: La consecución y mantenimiento de un buen acceso vascular sigue siendo una de las piezas claves para la realización de un tratamiento dialítico adecuado. Los catéteres de Tesio están demostrando ser una opción válida de acceso vascular. Objetivos y métodos: Hemos examinado todos los catéteres de Tesio colocados en nuestra Unidad a lo largo de tres años. Hemos analizado la edad, sexo, tiempo en diálisis, nefropatía de base, accesos vasculares previos, complicaciones, parámetros dialíticos, tiempo de funcionamiento en el momento del estudio, nivel de confort de pacientes y enfermeras y fallecimientos en todos estos pacientes. Resultados: En este tiempo se han colocado 33 catéteres a 30 pacientes, 14 hombres y 16 mujeres. Edad media 73,92 ± 9,22 años. Tiempo en diálisis 25,64 ± 53,45 meses. Nefropatía diabética 26,66 5, nefroangioesclerosis (NAE) 40%, otras causas 33,33%. Primer acceso vascular en 13 pacientes (43,33%), una FAV previa en 5 (16,66%) y más de una FAV previa en 12 (40%). Hemos tenido dos casos de sangrado, ocho de trombosis parcial, uno de obstrucción total (no funcionamiento), seis infecciones de tunel u orificio y dos infecciones sistémicas. Sólo en tres casos se precisó retirada del catéter. Los parámetros de diálisis analizados han sido satisfactorios. El grado de confort de pacientes y personal de enfermería ha sido bueno. Han fallecido 12 pacientes. El tiempo medio de funcionamiento en el momento del análisis era de 16,76 ± 12,99 meses. Conclusiones: Los catéteres de Tesio pueden constituir un buen acceso vascular permanente para la hemodiálisis, especialmente en pacientes mayores y con accesos vasculares previos fallidos. Presentan pocas complicaciones, buenos parámetros de diálisis y tolerancia. En cualquier caso, la fístula arteriovenosa autóloga todavía constituye la opción más deseable. Palabras clave: Catéteres de tesio permanentes. Hospital comarcal. INTRODUCTION The achievement and maintenance of a good vascular access for chronic hemodialysis performance still is one of the basic issues on which lies the health care staff responsibility working with renal patients. Aside from the preference for an autologous arterial-venous fistula, the choice of particular vascular access type for hemodialysis will depend on the urgency to initiate treatment, its life expectancy, patient's age, vascular anatomy, the patient's preference, as well as performance and functioning of previous vascular accesses1. 408 On the other hand, it is well known that we are facing a general and steady aging of our dialysis population, with the associated vascular issues2. There are basically three different types of vascular accesses for hemodialysis: the autologous arterial-venous fistula, reckoned as the most desirable in the general population and also with known drawbacks&#59; vascular grafts, of different materials and sites&#59; and catheters, either temporary (more used for hemodialysis in the acute patient) or the different modalities of funneled permanent catheters3. In recent years, several catheter types have been tried in dialysis, with particularities, advantages and drawbacks with each type. PERMANENT TESIO'S CATHETHERS.REGIONAL HOSPITAL Since their introduction at the beginning of the last decade, Tesio's funneled catheters have become one of the most well-known and used variants in hemodialysis units.4,5,6 OBJECTIVE The aim of our analysis has been to assess the efficacy, comfort and complications of Tesio's catheters, as well as the patient's profile receiving one of these catheters in our Unit for the last several years. MATERIAL AND METHODS We have followed 30 consecutive chronic renal patients in whom 33 pairs of funneled jugular Tesio's catheters were inserted in our Unit from January 2000 to February 2003. We have analyzed: 1. The profile of these patients: age, gender, baseline nephropathy, time on dialysis, and previous vascular accesses. 2. Immediate complications after insertion. 3. Further complications along time. 4. Efficacy: flows, dialysis dose (KtV), recirculation index and time from insertion to time on dialysis. 5. Mortality. 6. The degree of comfort of these patients and nursing staff caring for these patients. This parameter has been analyzed by direct questioning to patients and nursing staff. Catheters were inserted in our Unit under local anesthesia, with a single or double puncture technique as needed, with the collaboration of the nephrologist and an expert dialysis nurse. Preferably, both catheters were inserted with through a single venous puncture. The access route always was jugular (right or left, as needed). X-ray control was done after insertion, and the use started 214 hours later. An antibiotic prophylaxis with a single dose of vancomicina 500 mg was done. General asepsis precautions were taken in all patients with weekly topical application of ciprofloxacin (0.5 mL in each outlet opening). Two mL of 5% sodium heparin in each branch was used of anticoagulation. RESULTS 1. About our patients' profile: Table I: Baseline nephropathy Diabetic Nph. Num. of patients % 8,66 26,66 NAS 12 40 GN 4,33 13.33 Others 6 20 NAS: nephroangiosclerosis. GN = glomerulonephritis. Mean age of the patients was 73.92 _ 9.22 years, 46.6% (14) were males and 53.3% (16) females. Mean time from dialysis onset was 25.64 _ 53.45 months. Baseline nephropathies are shown in Table I: Previous vascular access of these patients are shown in Table II: Table II: Previous vascular accesses Num. of patients First access 1 previous AVF > 1 previous AVF 13 5 12 % 43.3 16.66 40 2. Immediate complications: With regards to complications occurred during catheter insertion, we had two cases of abundant bleeding. In one of them, we delayed insertion for 24 hours, and in the other one, once the catheters were inserted, surgical hemostasia was indicated with a good clinical course and catheter functioning. In none of the cases, catheter replacement was required. 3. Late complications: Late complications are shown in Table III: Table III: Delayed complications Num. of patients Partial thrombosis Total thrombosis Opening infection Bacteriemia 8 1 6 2 % 26.6 3.3 20 6.66 Partial thrombosis cases were resolved with urokinase fibrinolytic therapy (50,000 U with a 20-30 min IV infusion in the affected branch). For opening infections a supplemental dose of topical ciprofloxacin was used and a prophylactic dose of vancomi409 R. ÁLVAREZ NAVASCUÉS y cols. cin 500 mg. Only in two cases of catheter-attributable bacteriemia and in one non-functioning case we were obliged to remove the catheters. 4. Efficacy: Mean flows were 268 ± 40.32 mL/min. Kt/V was 1.2 ± 0.4. Mean duration per dialysis session and dialyzers have been highly variable depending on each patient characteristics. Analyzed recirculation indexes were 4.5 ± 2.8%. Mean time from catheter insertion until analysis was 16.76 ± 12.99 months. 5. Mortality: During this period, 12 (40%) patients died, similarly to other patients with the same age and other vascular access types. None of them was included in the renal transplantation waiting list. 6. Degree of comfort: When we asked our patients about the degree of comfort of catheters, the general feeling was good, particularly in those patients that had had previous arterial-venous fistulae and that avoided repeated vascular punctures. Similarly, the feeling of the nurse staff attending our patients has been satisfactory. DISCUSSION As discussed above, the achievement and maintenance of a good vascular access represents one of the major concerns of any health care staff attending renal patients submitted to chronic hemodialysis. The approach to vascular access in these patients must be multidisciplinary and must basically include the patient and the hemodialysis nursing staff, since they are the ones that better know the difficulties, discomforts and functioning, and the nephrologist who is must warrant the achievement of good dialysis parameters with the less possible complications, as well as the vascular surgeon and many times the interventional radiologist7. The profile of patients submitted to chronic hemodialysis in our units has substantially changed in the last decades, facing a generalized aging and an increase in life expectancy, with an increasing number of patients with several previous failed vascular accesses, and the presence of multiple associated comorbid conditions. During this time, several types of catheters for hemodialysis have emerged, more recommended in acute patients in which renal replacement therapy is 410 presumed to be short lived, although they are being used more and more in chronic patients, to a great extent due to theses patients characterisitics8-10. On the other hand, in many hospitals, as it is our case, there is a lack of vascular surgery, interventional radiology departments or endoscopic imaging. This represents a limitation and dependence level that may limit to a greater or lesser extent that our patients may benefit from the same opportunities than others that depend on reference hospitals. In our Unit, we have analyzed Tesio's catheters inserted during a three-year period. In our case, we have chosen this type of catheters based on the literature and on reported series with acceptable results4,8. They have been inserted in patients that had previous failed vascular accesses, or in other patients with advanced age, multiple associated conditions with a short life expectancy (myeloma, metastatic cancer, etc.) or with apparent poor vascular beds. As it can be observed from the outcomes, complications have been few (only in three patients catheter replacement was necessary) and easily overcome. In no case patient death was attributed to catheter-derived complications, in spite of the importance that a vascular access may have on renal patients morbidity and mortality11-13. On the other hand, and similarly to some published series,6,8,13-15 analyzed dialysis parameters (Kt/V, flows achieved, an recirculation indexes, have been satisfactory. Similarly, and contrary to what may seem, patients showed a high comfort level, especially those with multiple previous vascular accesses that, in this way, avoided repeated venous punctures. The high rate of deceased patients (40%) may be surprising. This is easily explained by the fact the patients were old and presented multiple associated conditions. One should considerer the high percentage of nephroangiosclerosis (40%) and diabetic nephropathy (26.66%), or the fact that none of them was in the renal transplantation waiting list. As well, there were patients with associated tumoral disease that worsened their life expectancy. All are poor prognosis data when entering into renal replacement therapy programs16-19. This high mortality rate would also explain that mean functioning time at the time of dialysis was only 16.76 months. The use of this type of catheters in elderly patients, with a short life expectancy at the time of starting on hemodialysis, may be a highly valid alternative from a clinical and financial point of view if we analyze the cost of performing arterial-venous fistulae for which, in our case, we must refer patients to other reference centers, and the cost PERMANENT TESIO'S CATHETHERS.REGIONAL HOSPITAL derived from the use of other temporary catheters, hospital admissions for catheter-related sepsis, or other related costs. We have no experience with the use of these catheters in young patients that will presumably receive soon a renal transplantation. The analysis of series that use them as temporary catheters may encourage its future usage20,21. In any case, the preference for an autologous arterial-venous fistula is still clear, if it is possible. Obviously, catheter use may have negative connotations in intermediate and long terms, even if these patients would be susceptible to transplantation. We have not compare the clinical course of our patients with Tesio's catheters with that of other patients with different vascular accesses. This would require a high number of patients as well as a prospective analysis. In any case, we do want to highlight the good result we are obtaining with this type of catheters, easily inserted at a regional hospital, without dependence on other departments, in a certain type of patients. It remains to be known the future implications with regards to vascular accesses for chronic hemodialysis. REFERENCES 1. NKF-K/DOQI Clinical practice guidelines for vascular access: Am J Kidney Dis 30 (Supl. 3): 157-158, 1997. 2. Gómez Campderá FJ, Polo JR, Sanabia J, Tejedor A: Primer acceso vascular para hemodiálisis en el anciano. Nefrología 15: 183-5, 1995. 3. Hassan HA, Frenchie DL, Bastani B: Effect of reversal of catheter ports on recirculation: comparison the PermCath with Tesio Twin Catheter. ASAIO J 48: 316-19, 2002. 4. Tesio F, Panarello G: Long-term vascular access: the Tesio catheter. Contrib Nephrol 142: 153-8, 2004. 5. Webb A, Abdalla M, Harden PN, Russell GI: Use of the Tesio catheter for hemodialysis in patients with end-stage renal failure: a 2-year prospective study. Clin Nephrol 58: 128-33, 2002. 6. Tesio F, Panarello G, De Baz H, Canzi M, De Mattia T, Pasut R: Central vascular access: rational and results. G Ital Nefrol 20 (22): 30-34, 2003. 7. Vassalotti JA, Falk A, Teodorescu V, Urribarri J: The multidisciplinary approach to hemodialysis vascular access in the Mount Sinai Hospital. Mt Sinai J Med 71: 94-102, 2004. 8. Prabhu PN, kerns SR, Sabatelli FW, Hawkins IF, Ross EA: Long-term performance and complications of the Tesio twin catheter system for hemodialysis access. Am J Kidney Dis 30: 213-8, 1997. 9. Kairaitis LK, Gottlieb T: Outcome and complications of temporary hemodialysis catheters. Nephrol Dial Transplant 14: 1710-1714, 1999. 10. Schwab SJ, Weiss MA, Rushton F, Ross JP, Jackson J, Kapoian T, Yeg Rosenblatt M, Reese WJ, Soundararajan R, Work J, Ross J, Stainken B, Pedan A, Moran JA. Multicenter clinical trial results with LifeSite hemodialysis access system. Kidney Int 62: 1026-1033, 2002. 11. Polkinghorne KR, McDonald SP, Atkins RC, Kerr PG. Vascular access and all-cause mortality: a propensity score analysis. J Am Soc Nephrol 15: 477-86, 2004. 12. Cardelli R, D'Amicone M, Gurioli L, Biselli L, Priasca GC, Grott G, Manzione A: Permanent vascular catheters for extracorporeal dialysis. Preliminaty study: Canaud and Tesio catheters. Minerva Urol Nefrol 50: 51-54, 1998. 13. Mannesse P, Bosch FH: Percutaneous jugular Tesio catheter useful for long-term Hemodialysis: experiences in 26 patients. Ned Tijdschr Geneeskd 142: 247-51, 1998. 14. Ferrari G, Talassi E, Baraldi C, Lombertini D, Tarchini R: Vascular access validity and treatment efficiency in hemodiálysis. G Ital Nefrol 20: 22-29, 2003. 15. Wivell W, Bettmann MA, Baxter B, Langdon DR, Remilliard B, Choba M: Outcomes and performance of the Tesio twin catheter system placed for hemodialysis access. Radiology 221: 697-703, 2001. 16. Perunicic-Pekovic G, Rasic-Milutinovic Z, Pljesa S: Predictors of mortality in dialysis patients-association between malnutrition, inflammation and atherosclerosis (MIA Syndrome). Med Pregl 57: 149-152, 2004. 17. Locatelli F, Manzoni C, Pozzoni P, Pontoriero G, Di Filippo L: Clinical dialysis:New problems and new prospects. G Ital Nefrol 21: 156-164, 2004. 18. Vonesh EF, Snyder JJ, Foley RN, Collins AJ. The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis. Kidney Int 66: 2389-2401, 2004. 19. Goodkin DA, Young EW, Kurokawa K, Prutz KG, Levin NW: Mortality among hemodialysis patients in Europe, Japan and the United States: case-mix effects. Am J Kidney Dis 44: 16-21, 2004. 20. Sheth RD, Kale AS, Brewer ED, Brandt ML, Nuchtern JG, Goldstein S: Successful use of Tesio catheters in pediatric patients receiving chronic hemodialysis. Am J Kidney Dis 38: 553-559, 2001. 21. Sharma A, Zilleruelo G, Abitbol C, Montane B, Strauss J. Survival and complications of cuffed catheters in children on chronic hemodialysis. Pediatr Nephrol 13: 245-248, 1999. 411 "
    "pdfFichero" => "P1-E244-S132-A3307.pdf"
    "tienePdf" => true
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018440/v0_201502091335/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35393"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Artículos Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000002500000004/v0_201502091335/X0211699505018440/v0_201502091335/en/P1-E244-S132-A3307.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018440?idApp=UINPBA000064"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Tesio catheters for long-term hemodialysis: our experience in a comarcal hospital
R. Álvarez Navascués, L. Quiñones, J. Guerediaga
Leído
8856
Veces
se ha leído el artículo
2333
Total PDF
6523
Total HTML
Compartir estadísticas
 array:19 [
  "pii" => "X0211699505018440"
  "issn" => "02116995"
  "estado" => "S300"
  "fechaPublicacion" => "2005-08-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2005;25:407-11"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4632
    "formatos" => array:3 [
      "EPUB" => 254
      "HTML" => 3772
      "PDF" => 606
    ]
  ]
  "itemSiguiente" => array:15 [
    "pii" => "X0211699505018612"
    "issn" => "02116995"
    "estado" => "S300"
    "fechaPublicacion" => "2005-08-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2005;25:407-11"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 10082
      "formatos" => array:3 [
        "EPUB" => 252
        "HTML" => 8533
        "PDF" => 1297
      ]
    ]
    "es" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Catéteres de tesio permanentes para realización de hemodiálisis crónica"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "407"
          "paginaFinal" => "411"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018612?idApp=UINPBA000064"
    "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018612/v0_201502091335/es/main.assets"
  ]
  "itemAnterior" => array:15 [
    "pii" => "X0211699505018459"
    "issn" => "02116995"
    "estado" => "S300"
    "fechaPublicacion" => "2005-08-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2005;25:399-406"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5479
      "formatos" => array:3 [
        "EPUB" => 256
        "HTML" => 4546
        "PDF" => 677
      ]
    ]
    "en" => array:8 [
      "idiomaDefecto" => true
      "titulo" => "Incidence and risk factors for non traumatic lower extremity amputation inhemodialysis patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "399"
          "paginaFinal" => "406"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. C. Sánchez Perales, M. J. García Cortés, F. J. Borrego Utiel, G. Viedma, J. M. Gil, P. Pérez del Barrio, J. Borrego Hinojosa, A. Liébana, V. Pérez"
          "autores" => array:1 [
            0 => array:1 [
              "nombre" => "M. C. Sánchez Perales, M. J. García Cortés, F. J. Borrego Utiel, G. Viedma, J. M. Gil, P. Pérez del Barrio, J. Borrego Hinojosa, A. Liébana, V. Pérez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018459?idApp=UINPBA000064"
    "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018459/v0_201502091335/en/main.assets"
  ]
  "en" => array:8 [
    "idiomaDefecto" => true
    "titulo" => "Tesio catheters for long-term hemodialysis: our experience in a comarcal hospital"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "407"
        "paginaFinal" => "411"
      ]
    ]
    "autores" => array:1 [
      0 => array:2 [
        "autoresLista" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
        "autores" => array:1 [
          0 => array:1 [
            "nombre" => "R. Álvarez Navascués, L. Quiñones, J. Guerediaga"
          ]
        ]
      ]
    ]
    "textoCompleto" => "NEFROLOGÍA. Volumen 25. Número 4. 2005 Permanent Tesio's catheters for chronic hemodialysis: our experience at a regional hospital R. Álvarez Navascués, L. Quiñones and J. Guerediaga Nephrology Department. San Agustín Hospital. Avilés. Asturias. SUMMARY Introduction: Good vascular access remains the cornerstone of effective hemodialysis treatment. The Tesio catheters has been proposed to be a reliable source of vascular access for the dialysis patients. Subjects and methods: We examined all Tesio catheters inserted over a 3-year period in our hospital. We obtained age, sex, dialysis duration, original nephropaty, vascular access history, complications, dialysis parameters, catheter function duration, confort level for patients and nurses, and death in all our cases. Results: 33 catheters were inserted in 30 patients, 14 male and 16 female. Age 73,92 ± 9,22 years. Dialysis duration, 25,64 ± 53,45 months. Diabetic nephropaty 26,66%, NAE 40%, others 33,33%. First vascular access in 13 patients (43,33%), one previously fistula, 5 patients (16,66%), and more of one FAV, 12 patients (40%). We observed two bleeding cases, eight parcial trombosis, one total trombosis (non-function), six tunneled infection and two systemic infection. Only 3 catheters were removal. We obteined good dialysis parameters. Confort state for patients and nurses were satisfactory. Death 12 patients. Catheter function at the moment of study 16,76 ± 12,99 months. Conclusions: We conclued that Tesio catheters can provide excellent long-term vascular access for hemodialysis patients, especially in the older people and with some previous failure fistulas, with low complication rates and acceptable dialysis parameters and tolerance. However, the arteriovenous fistula remains the gold standard for long-term hemodialysis access. Key words: Permanent Tesio catheter. Comarcal Hospital. Correspondence: Dr. Rafael Álvarez Navascués Servicio de Nefrología Hospital San Agustín Camino de los Heros, 4 33400 Avilés (Asturias) 407 R. ÁLVAREZ NAVASCUÉS y cols. CATÉTERES DE TESIO PERMANENTES PARA REALIZACIÓN DE HEMODIÁLISIS CRÓNICA: NUESTRA EXPERIENCIA EN UN HOSPITAL COMARCAL RESUMEN Introducción: La consecución y mantenimiento de un buen acceso vascular sigue siendo una de las piezas claves para la realización de un tratamiento dialítico adecuado. Los catéteres de Tesio están demostrando ser una opción válida de acceso vascular. Objetivos y métodos: Hemos examinado todos los catéteres de Tesio colocados en nuestra Unidad a lo largo de tres años. Hemos analizado la edad, sexo, tiempo en diálisis, nefropatía de base, accesos vasculares previos, complicaciones, parámetros dialíticos, tiempo de funcionamiento en el momento del estudio, nivel de confort de pacientes y enfermeras y fallecimientos en todos estos pacientes. Resultados: En este tiempo se han colocado 33 catéteres a 30 pacientes, 14 hombres y 16 mujeres. Edad media 73,92 ± 9,22 años. Tiempo en diálisis 25,64 ± 53,45 meses. Nefropatía diabética 26,66 5, nefroangioesclerosis (NAE) 40%, otras causas 33,33%. Primer acceso vascular en 13 pacientes (43,33%), una FAV previa en 5 (16,66%) y más de una FAV previa en 12 (40%). Hemos tenido dos casos de sangrado, ocho de trombosis parcial, uno de obstrucción total (no funcionamiento), seis infecciones de tunel u orificio y dos infecciones sistémicas. Sólo en tres casos se precisó retirada del catéter. Los parámetros de diálisis analizados han sido satisfactorios. El grado de confort de pacientes y personal de enfermería ha sido bueno. Han fallecido 12 pacientes. El tiempo medio de funcionamiento en el momento del análisis era de 16,76 ± 12,99 meses. Conclusiones: Los catéteres de Tesio pueden constituir un buen acceso vascular permanente para la hemodiálisis, especialmente en pacientes mayores y con accesos vasculares previos fallidos. Presentan pocas complicaciones, buenos parámetros de diálisis y tolerancia. En cualquier caso, la fístula arteriovenosa autóloga todavía constituye la opción más deseable. Palabras clave: Catéteres de tesio permanentes. Hospital comarcal. INTRODUCTION The achievement and maintenance of a good vascular access for chronic hemodialysis performance still is one of the basic issues on which lies the health care staff responsibility working with renal patients. Aside from the preference for an autologous arterial-venous fistula, the choice of particular vascular access type for hemodialysis will depend on the urgency to initiate treatment, its life expectancy, patient's age, vascular anatomy, the patient's preference, as well as performance and functioning of previous vascular accesses1. 408 On the other hand, it is well known that we are facing a general and steady aging of our dialysis population, with the associated vascular issues2. There are basically three different types of vascular accesses for hemodialysis: the autologous arterial-venous fistula, reckoned as the most desirable in the general population and also with known drawbacks&#59; vascular grafts, of different materials and sites&#59; and catheters, either temporary (more used for hemodialysis in the acute patient) or the different modalities of funneled permanent catheters3. In recent years, several catheter types have been tried in dialysis, with particularities, advantages and drawbacks with each type. PERMANENT TESIO'S CATHETHERS.REGIONAL HOSPITAL Since their introduction at the beginning of the last decade, Tesio's funneled catheters have become one of the most well-known and used variants in hemodialysis units.4,5,6 OBJECTIVE The aim of our analysis has been to assess the efficacy, comfort and complications of Tesio's catheters, as well as the patient's profile receiving one of these catheters in our Unit for the last several years. MATERIAL AND METHODS We have followed 30 consecutive chronic renal patients in whom 33 pairs of funneled jugular Tesio's catheters were inserted in our Unit from January 2000 to February 2003. We have analyzed: 1. The profile of these patients: age, gender, baseline nephropathy, time on dialysis, and previous vascular accesses. 2. Immediate complications after insertion. 3. Further complications along time. 4. Efficacy: flows, dialysis dose (KtV), recirculation index and time from insertion to time on dialysis. 5. Mortality. 6. The degree of comfort of these patients and nursing staff caring for these patients. This parameter has been analyzed by direct questioning to patients and nursing staff. Catheters were inserted in our Unit under local anesthesia, with a single or double puncture technique as needed, with the collaboration of the nephrologist and an expert dialysis nurse. Preferably, both catheters were inserted with through a single venous puncture. The access route always was jugular (right or left, as needed). X-ray control was done after insertion, and the use started 214 hours later. An antibiotic prophylaxis with a single dose of vancomicina 500 mg was done. General asepsis precautions were taken in all patients with weekly topical application of ciprofloxacin (0.5 mL in each outlet opening). Two mL of 5% sodium heparin in each branch was used of anticoagulation. RESULTS 1. About our patients' profile: Table I: Baseline nephropathy Diabetic Nph. Num. of patients % 8,66 26,66 NAS 12 40 GN 4,33 13.33 Others 6 20 NAS: nephroangiosclerosis. GN = glomerulonephritis. Mean age of the patients was 73.92 _ 9.22 years, 46.6% (14) were males and 53.3% (16) females. Mean time from dialysis onset was 25.64 _ 53.45 months. Baseline nephropathies are shown in Table I: Previous vascular access of these patients are shown in Table II: Table II: Previous vascular accesses Num. of patients First access 1 previous AVF > 1 previous AVF 13 5 12 % 43.3 16.66 40 2. Immediate complications: With regards to complications occurred during catheter insertion, we had two cases of abundant bleeding. In one of them, we delayed insertion for 24 hours, and in the other one, once the catheters were inserted, surgical hemostasia was indicated with a good clinical course and catheter functioning. In none of the cases, catheter replacement was required. 3. Late complications: Late complications are shown in Table III: Table III: Delayed complications Num. of patients Partial thrombosis Total thrombosis Opening infection Bacteriemia 8 1 6 2 % 26.6 3.3 20 6.66 Partial thrombosis cases were resolved with urokinase fibrinolytic therapy (50,000 U with a 20-30 min IV infusion in the affected branch). For opening infections a supplemental dose of topical ciprofloxacin was used and a prophylactic dose of vancomi409 R. ÁLVAREZ NAVASCUÉS y cols. cin 500 mg. Only in two cases of catheter-attributable bacteriemia and in one non-functioning case we were obliged to remove the catheters. 4. Efficacy: Mean flows were 268 ± 40.32 mL/min. Kt/V was 1.2 ± 0.4. Mean duration per dialysis session and dialyzers have been highly variable depending on each patient characteristics. Analyzed recirculation indexes were 4.5 ± 2.8%. Mean time from catheter insertion until analysis was 16.76 ± 12.99 months. 5. Mortality: During this period, 12 (40%) patients died, similarly to other patients with the same age and other vascular access types. None of them was included in the renal transplantation waiting list. 6. Degree of comfort: When we asked our patients about the degree of comfort of catheters, the general feeling was good, particularly in those patients that had had previous arterial-venous fistulae and that avoided repeated vascular punctures. Similarly, the feeling of the nurse staff attending our patients has been satisfactory. DISCUSSION As discussed above, the achievement and maintenance of a good vascular access represents one of the major concerns of any health care staff attending renal patients submitted to chronic hemodialysis. The approach to vascular access in these patients must be multidisciplinary and must basically include the patient and the hemodialysis nursing staff, since they are the ones that better know the difficulties, discomforts and functioning, and the nephrologist who is must warrant the achievement of good dialysis parameters with the less possible complications, as well as the vascular surgeon and many times the interventional radiologist7. The profile of patients submitted to chronic hemodialysis in our units has substantially changed in the last decades, facing a generalized aging and an increase in life expectancy, with an increasing number of patients with several previous failed vascular accesses, and the presence of multiple associated comorbid conditions. During this time, several types of catheters for hemodialysis have emerged, more recommended in acute patients in which renal replacement therapy is 410 presumed to be short lived, although they are being used more and more in chronic patients, to a great extent due to theses patients characterisitics8-10. On the other hand, in many hospitals, as it is our case, there is a lack of vascular surgery, interventional radiology departments or endoscopic imaging. This represents a limitation and dependence level that may limit to a greater or lesser extent that our patients may benefit from the same opportunities than others that depend on reference hospitals. In our Unit, we have analyzed Tesio's catheters inserted during a three-year period. In our case, we have chosen this type of catheters based on the literature and on reported series with acceptable results4,8. They have been inserted in patients that had previous failed vascular accesses, or in other patients with advanced age, multiple associated conditions with a short life expectancy (myeloma, metastatic cancer, etc.) or with apparent poor vascular beds. As it can be observed from the outcomes, complications have been few (only in three patients catheter replacement was necessary) and easily overcome. In no case patient death was attributed to catheter-derived complications, in spite of the importance that a vascular access may have on renal patients morbidity and mortality11-13. On the other hand, and similarly to some published series,6,8,13-15 analyzed dialysis parameters (Kt/V, flows achieved, an recirculation indexes, have been satisfactory. Similarly, and contrary to what may seem, patients showed a high comfort level, especially those with multiple previous vascular accesses that, in this way, avoided repeated venous punctures. The high rate of deceased patients (40%) may be surprising. This is easily explained by the fact the patients were old and presented multiple associated conditions. One should considerer the high percentage of nephroangiosclerosis (40%) and diabetic nephropathy (26.66%), or the fact that none of them was in the renal transplantation waiting list. As well, there were patients with associated tumoral disease that worsened their life expectancy. All are poor prognosis data when entering into renal replacement therapy programs16-19. This high mortality rate would also explain that mean functioning time at the time of dialysis was only 16.76 months. The use of this type of catheters in elderly patients, with a short life expectancy at the time of starting on hemodialysis, may be a highly valid alternative from a clinical and financial point of view if we analyze the cost of performing arterial-venous fistulae for which, in our case, we must refer patients to other reference centers, and the cost PERMANENT TESIO'S CATHETHERS.REGIONAL HOSPITAL derived from the use of other temporary catheters, hospital admissions for catheter-related sepsis, or other related costs. We have no experience with the use of these catheters in young patients that will presumably receive soon a renal transplantation. The analysis of series that use them as temporary catheters may encourage its future usage20,21. In any case, the preference for an autologous arterial-venous fistula is still clear, if it is possible. Obviously, catheter use may have negative connotations in intermediate and long terms, even if these patients would be susceptible to transplantation. We have not compare the clinical course of our patients with Tesio's catheters with that of other patients with different vascular accesses. This would require a high number of patients as well as a prospective analysis. In any case, we do want to highlight the good result we are obtaining with this type of catheters, easily inserted at a regional hospital, without dependence on other departments, in a certain type of patients. It remains to be known the future implications with regards to vascular accesses for chronic hemodialysis. REFERENCES 1. NKF-K/DOQI Clinical practice guidelines for vascular access: Am J Kidney Dis 30 (Supl. 3): 157-158, 1997. 2. Gómez Campderá FJ, Polo JR, Sanabia J, Tejedor A: Primer acceso vascular para hemodiálisis en el anciano. Nefrología 15: 183-5, 1995. 3. Hassan HA, Frenchie DL, Bastani B: Effect of reversal of catheter ports on recirculation: comparison the PermCath with Tesio Twin Catheter. ASAIO J 48: 316-19, 2002. 4. Tesio F, Panarello G: Long-term vascular access: the Tesio catheter. Contrib Nephrol 142: 153-8, 2004. 5. Webb A, Abdalla M, Harden PN, Russell GI: Use of the Tesio catheter for hemodialysis in patients with end-stage renal failure: a 2-year prospective study. Clin Nephrol 58: 128-33, 2002. 6. Tesio F, Panarello G, De Baz H, Canzi M, De Mattia T, Pasut R: Central vascular access: rational and results. G Ital Nefrol 20 (22): 30-34, 2003. 7. Vassalotti JA, Falk A, Teodorescu V, Urribarri J: The multidisciplinary approach to hemodialysis vascular access in the Mount Sinai Hospital. Mt Sinai J Med 71: 94-102, 2004. 8. Prabhu PN, kerns SR, Sabatelli FW, Hawkins IF, Ross EA: Long-term performance and complications of the Tesio twin catheter system for hemodialysis access. Am J Kidney Dis 30: 213-8, 1997. 9. Kairaitis LK, Gottlieb T: Outcome and complications of temporary hemodialysis catheters. Nephrol Dial Transplant 14: 1710-1714, 1999. 10. Schwab SJ, Weiss MA, Rushton F, Ross JP, Jackson J, Kapoian T, Yeg Rosenblatt M, Reese WJ, Soundararajan R, Work J, Ross J, Stainken B, Pedan A, Moran JA. Multicenter clinical trial results with LifeSite hemodialysis access system. Kidney Int 62: 1026-1033, 2002. 11. Polkinghorne KR, McDonald SP, Atkins RC, Kerr PG. Vascular access and all-cause mortality: a propensity score analysis. J Am Soc Nephrol 15: 477-86, 2004. 12. Cardelli R, D'Amicone M, Gurioli L, Biselli L, Priasca GC, Grott G, Manzione A: Permanent vascular catheters for extracorporeal dialysis. Preliminaty study: Canaud and Tesio catheters. Minerva Urol Nefrol 50: 51-54, 1998. 13. Mannesse P, Bosch FH: Percutaneous jugular Tesio catheter useful for long-term Hemodialysis: experiences in 26 patients. Ned Tijdschr Geneeskd 142: 247-51, 1998. 14. Ferrari G, Talassi E, Baraldi C, Lombertini D, Tarchini R: Vascular access validity and treatment efficiency in hemodiálysis. G Ital Nefrol 20: 22-29, 2003. 15. Wivell W, Bettmann MA, Baxter B, Langdon DR, Remilliard B, Choba M: Outcomes and performance of the Tesio twin catheter system placed for hemodialysis access. Radiology 221: 697-703, 2001. 16. Perunicic-Pekovic G, Rasic-Milutinovic Z, Pljesa S: Predictors of mortality in dialysis patients-association between malnutrition, inflammation and atherosclerosis (MIA Syndrome). Med Pregl 57: 149-152, 2004. 17. Locatelli F, Manzoni C, Pozzoni P, Pontoriero G, Di Filippo L: Clinical dialysis:New problems and new prospects. G Ital Nefrol 21: 156-164, 2004. 18. Vonesh EF, Snyder JJ, Foley RN, Collins AJ. The differential impact of risk factors on mortality in hemodialysis and peritoneal dialysis. Kidney Int 66: 2389-2401, 2004. 19. Goodkin DA, Young EW, Kurokawa K, Prutz KG, Levin NW: Mortality among hemodialysis patients in Europe, Japan and the United States: case-mix effects. Am J Kidney Dis 44: 16-21, 2004. 20. Sheth RD, Kale AS, Brewer ED, Brandt ML, Nuchtern JG, Goldstein S: Successful use of Tesio catheters in pediatric patients receiving chronic hemodialysis. Am J Kidney Dis 38: 553-559, 2001. 21. Sharma A, Zilleruelo G, Abitbol C, Montane B, Strauss J. Survival and complications of cuffed catheters in children on chronic hemodialysis. Pediatr Nephrol 13: 245-248, 1999. 411 "
    "pdfFichero" => "P1-E244-S132-A3307.pdf"
    "tienePdf" => true
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000002500000004/v0_201502091335/X0211699505018440/v0_201502091335/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35393"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Artículos Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000002500000004/v0_201502091335/X0211699505018440/v0_201502091335/en/P1-E244-S132-A3307.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699505018440?idApp=UINPBA000064"
]
Información del artículo
ISSN: 02116995
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 3 4 7
2024 Octubre 49 60 109
2024 Septiembre 59 44 103
2024 Agosto 82 66 148
2024 Julio 42 25 67
2024 Junio 59 35 94
2024 Mayo 61 28 89
2024 Abril 55 28 83
2024 Marzo 32 21 53
2024 Febrero 42 29 71
2024 Enero 30 32 62
2023 Diciembre 31 22 53
2023 Noviembre 58 28 86
2023 Octubre 54 30 84
2023 Septiembre 68 30 98
2023 Agosto 43 23 66
2023 Julio 72 28 100
2023 Junio 47 18 65
2023 Mayo 66 32 98
2023 Abril 45 21 66
2023 Marzo 36 22 58
2023 Febrero 58 29 87
2023 Enero 37 26 63
2022 Diciembre 49 39 88
2022 Noviembre 45 32 77
2022 Octubre 51 43 94
2022 Septiembre 51 41 92
2022 Agosto 68 40 108
2022 Julio 37 48 85
2022 Junio 50 40 90
2022 Mayo 41 43 84
2022 Abril 43 37 80
2022 Marzo 51 41 92
2022 Febrero 46 40 86
2022 Enero 40 31 71
2021 Diciembre 58 54 112
2021 Noviembre 47 34 81
2021 Octubre 55 53 108
2021 Septiembre 38 29 67
2021 Agosto 33 34 67
2021 Julio 49 35 84
2021 Junio 28 21 49
2021 Mayo 33 27 60
2021 Abril 69 43 112
2021 Marzo 47 30 77
2021 Febrero 79 28 107
2021 Enero 53 24 77
2020 Diciembre 34 18 52
2020 Noviembre 41 12 53
2020 Octubre 34 11 45
2020 Septiembre 32 12 44
2020 Agosto 53 15 68
2020 Julio 44 16 60
2020 Junio 39 21 60
2020 Mayo 73 23 96
2020 Abril 44 16 60
2020 Marzo 44 14 58
2020 Febrero 48 8 56
2020 Enero 74 23 97
2019 Diciembre 67 21 88
2019 Noviembre 79 14 93
2019 Octubre 75 8 83
2019 Septiembre 78 20 98
2019 Agosto 55 17 72
2019 Julio 47 20 67
2019 Junio 40 15 55
2019 Mayo 46 30 76
2019 Abril 92 39 131
2019 Marzo 43 17 60
2019 Febrero 31 13 44
2019 Enero 32 11 43
2018 Diciembre 74 31 105
2018 Noviembre 62 19 81
2018 Octubre 52 12 64
2018 Septiembre 51 20 71
2018 Agosto 51 17 68
2018 Julio 36 16 52
2018 Junio 48 20 68
2018 Mayo 28 14 42
2018 Abril 43 11 54
2018 Marzo 35 14 49
2018 Febrero 41 3 44
2018 Enero 52 9 61
2017 Diciembre 47 6 53
2017 Noviembre 36 9 45
2017 Octubre 46 8 54
2017 Septiembre 37 5 42
2017 Agosto 53 9 62
2017 Julio 49 15 64
2017 Junio 67 13 80
2017 Mayo 43 16 59
2017 Abril 51 6 57
2017 Marzo 41 11 52
2017 Febrero 35 8 43
2017 Enero 29 10 39
2016 Diciembre 55 9 64
2016 Noviembre 72 12 84
2016 Octubre 74 12 86
2016 Septiembre 97 7 104
2016 Agosto 190 4 194
2016 Julio 143 5 148
2016 Junio 93 0 93
2016 Mayo 150 0 150
2016 Abril 93 0 93
2016 Marzo 72 0 72
2016 Febrero 98 0 98
2016 Enero 112 0 112
2015 Diciembre 118 0 118
2015 Noviembre 93 0 93
2015 Octubre 97 0 97
2015 Septiembre 95 0 95
2015 Agosto 70 0 70
2015 Julio 65 0 65
2015 Junio 24 0 24
2015 Mayo 61 0 61
2015 Abril 8 0 8
2015 Febrero 1 0 1
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Nefrología
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?