se ha leído el artículo
array:19 [ "pii" => "X0211699504029688" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2004-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2004;24 Supl 1:27" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2029 "formatos" => array:3 [ "EPUB" => 225 "HTML" => 1376 "PDF" => 428 ] ] "itemSiguiente" => array:15 [ "pii" => "X021169950402967X" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2004-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2004;24 Supl 1:28" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2123 "formatos" => array:3 [ "EPUB" => 257 "HTML" => 1444 "PDF" => 422 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Progresión del sistema renina angiotensina, remisión y regresión de las nefropatías crónicas" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "28" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. REMUZZI" "autores" => array:1 [ 0 => array:1 [ "nombre" => "G. REMUZZI" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950402967X?idApp=UINPBA000064" "url" => "/02116995/00000024000000S1/v0_201502091335/X021169950402967X/v0_201502091335/en/main.assets" ] "itemAnterior" => array:15 [ "pii" => "X0211699504029696" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2004-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2004;24 Supl 1:26" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2629 "formatos" => array:3 [ "EPUB" => 248 "HTML" => 1928 "PDF" => 453 ] ] "es" => array:8 [ "idiomaDefecto" => true "titulo" => "Angiotensina II: auténtica citoquina en el daño vascular" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "26" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. EGIDO , M. RUIZ-ORTEGA , V. ESTEBAN , M. RUPEREZ , E. SANCHEZ LOPEZ , A. F. LOPEZ , J. RODRIGUEZ VITA" "autores" => array:1 [ 0 => array:1 [ "nombre" => "J. EGIDO , M. RUIZ-ORTEGA , V. ESTEBAN , M. RUPEREZ , E. SANCHEZ LOPEZ , A. F. LOPEZ , J. RODRIGUEZ VITA" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699504029696?idApp=UINPBA000064" "url" => "/02116995/00000024000000S1/v0_201502091335/X0211699504029696/v0_201502091335/es/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Efecto del bloqueo del sistema renina angiotensina sobre la progresión de la nefropatía diabética" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "27" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. SHAHINFAR" "autores" => array:1 [ 0 => array:1 [ "nombre" => "S. SHAHINFAR" ] ] ] ] "textoCompleto" => "NEFROLOGÍA. Vol. XXIV. Número Extraordinario (I). 2004 Efecto del bloqueo del sistema renina angiotensina sobre la progresión de la nefropatía diabética S. Shahinfar, M.D. Pennsylvania. USA. Diabetes mellitus is one of the most common diseases worldwide. It has been estimated that the total number of diabetic patients worldwide will increase from 123 million (1997) to 220 million by the Year 2010, with approximately 97% of all diabetics being type 2. Up to 40% of type 2 diabetics develop kidney disease, and in certain geographical regions, approximately 40% of new patients receiving renal replacement therapy have diabetic nephropathy. In the United States, the overall incidence of ESRD continues to increase, while the number of new ESRD cases attributed to diabetes is projected to rise sevenfold by 2030. Both hemodynamic and non-hemodynamic mechanisms may contribute to the progression of diabetic nephropathy. Since angiotensin II (AII) plays a central role in these mechanisms, it therefore has been hypothesized that blockade of AII would be renal protective in patients with type 2 diabetes. In experimental models of both non-diabetic and diabetic renal disease, AII receptor antagonism with losartan has been shown to reduce intraglomerular pressure and glomerular sclerosis, and reduce urinary protein excretion. These findings were supported in non-diabetic patients where losartan lowered blood pressure, decreased urinary protein excretion, and elevated renal plasma flow. In type 1 diabetes, ACE inhibition was demonstrated to slow the progression of renal disease, however there was no definitive evidence of a benefit on ESRD in type 2 diabetes. The RENAAL study was initiated to investigate the long-term renal protective effects of losartan in pa- tients with type 2 diabetes and nephropathy. The study demonstrated that losartan compared to placebo (with or without conventional antihypertensive therapy) significantly reduced the incidence of and delayed the time to the composite outcome of doubling of serum creatinine, ESRD, or death. RENAAL also demonstrated for the first time that blockade of angiotensin II with losartan delayed ESRD and the composite endpoint of ESRD or death. Losartan compared to placebo also significantly reduced proteinuria over time. The RENAAL study also revealed the association between important risk factors and renal outcomes in this type 2 diabetic population with nephropathy. Baseline metabolic factors were shown to be associated with the composite endpoint as well as ESRD, while anemia was shown to be an independent risk factor for rate of glomerular filtration rate decline and ESRD. Baseline proteinuria also was shown to be an important predictor for renal outcomes in this population. Furthermore, from RENAAL we have learned that imbalances in distribution of baseline proteinuria between treatment groups may affect treatment outcomes in studies of renal diseases. In summary, the results from the RENAAL study have fulfilled an unmet medical need by providing evidence that AII receptor antagonism is effective in delaying the onset of ESRD in type 2 diabetes, and well-tolerated in this vulnerable population. This study also revealed important information on the predictive nature of certain risk factors for renal outcome in type 2 diabetic patients with nephropathy. 27 " "pdfFichero" => "P7-E232-S132-A2977.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/02116995/00000024000000S1/v0_201502091335/X0211699504029688/v0_201502091335/en/main.assets" "Apartado" => array:4 [ "identificador" => "35393" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Artículos Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/00000024000000S1/v0_201502091335/X0211699504029688/v0_201502091335/en/P7-E232-S132-A2977.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699504029688?idApp=UINPBA000064" ]
Idioma original: Inglés
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 3 | 11 | 14 |
2024 Octubre | 40 | 27 | 67 |
2024 Septiembre | 40 | 30 | 70 |
2024 Agosto | 55 | 48 | 103 |
2024 Julio | 36 | 21 | 57 |
2024 Junio | 50 | 36 | 86 |
2024 Mayo | 48 | 25 | 73 |
2024 Abril | 38 | 26 | 64 |
2024 Marzo | 28 | 23 | 51 |
2024 Febrero | 28 | 34 | 62 |
2024 Enero | 28 | 22 | 50 |
2023 Diciembre | 24 | 20 | 44 |
2023 Noviembre | 34 | 22 | 56 |
2023 Octubre | 21 | 24 | 45 |
2023 Septiembre | 24 | 31 | 55 |
2023 Agosto | 38 | 25 | 63 |
2023 Julio | 28 | 20 | 48 |
2023 Junio | 32 | 14 | 46 |
2023 Mayo | 35 | 29 | 64 |
2023 Abril | 23 | 16 | 39 |
2023 Marzo | 18 | 21 | 39 |
2023 Febrero | 28 | 22 | 50 |
2023 Enero | 36 | 27 | 63 |
2022 Diciembre | 39 | 33 | 72 |
2022 Noviembre | 38 | 27 | 65 |
2022 Octubre | 34 | 46 | 80 |
2022 Septiembre | 28 | 25 | 53 |
2022 Agosto | 35 | 34 | 69 |
2022 Julio | 31 | 59 | 90 |
2022 Junio | 23 | 32 | 55 |
2022 Mayo | 31 | 33 | 64 |
2022 Abril | 35 | 45 | 80 |
2022 Marzo | 40 | 32 | 72 |
2022 Febrero | 35 | 28 | 63 |
2022 Enero | 26 | 33 | 59 |
2021 Diciembre | 45 | 33 | 78 |
2021 Noviembre | 29 | 38 | 67 |
2021 Octubre | 25 | 34 | 59 |
2021 Septiembre | 30 | 38 | 68 |
2021 Agosto | 20 | 36 | 56 |
2021 Julio | 26 | 23 | 49 |
2021 Junio | 17 | 13 | 30 |
2021 Mayo | 24 | 36 | 60 |
2021 Abril | 65 | 50 | 115 |
2021 Marzo | 30 | 28 | 58 |
2021 Febrero | 36 | 14 | 50 |
2021 Enero | 18 | 12 | 30 |
2020 Diciembre | 16 | 14 | 30 |
2020 Noviembre | 18 | 3 | 21 |
2020 Octubre | 11 | 13 | 24 |
2020 Septiembre | 7 | 6 | 13 |
2020 Agosto | 26 | 6 | 32 |
2020 Julio | 34 | 11 | 45 |
2020 Junio | 15 | 11 | 26 |
2020 Mayo | 35 | 17 | 52 |
2020 Abril | 32 | 16 | 48 |
2020 Marzo | 17 | 11 | 28 |
2020 Febrero | 30 | 18 | 48 |
2020 Enero | 29 | 22 | 51 |
2019 Diciembre | 21 | 14 | 35 |
2019 Noviembre | 26 | 16 | 42 |
2019 Octubre | 14 | 7 | 21 |
2019 Septiembre | 21 | 16 | 37 |
2019 Agosto | 3 | 10 | 13 |
2019 Julio | 21 | 23 | 44 |
2019 Junio | 18 | 15 | 33 |
2019 Mayo | 15 | 23 | 38 |
2019 Abril | 38 | 27 | 65 |
2019 Marzo | 12 | 15 | 27 |
2019 Febrero | 12 | 10 | 22 |
2019 Enero | 12 | 13 | 25 |
2018 Diciembre | 34 | 25 | 59 |
2018 Noviembre | 45 | 9 | 54 |
2018 Octubre | 44 | 14 | 58 |
2018 Septiembre | 26 | 10 | 36 |
2018 Agosto | 17 | 8 | 25 |
2018 Julio | 17 | 11 | 28 |
2018 Junio | 13 | 8 | 21 |
2018 Mayo | 23 | 12 | 35 |
2018 Abril | 16 | 8 | 24 |
2018 Marzo | 17 | 7 | 24 |
2018 Febrero | 17 | 5 | 22 |
2018 Enero | 17 | 5 | 22 |
2017 Diciembre | 19 | 4 | 23 |
2017 Noviembre | 14 | 6 | 20 |
2017 Octubre | 17 | 4 | 21 |
2017 Septiembre | 9 | 8 | 17 |
2017 Agosto | 11 | 5 | 16 |
2017 Julio | 12 | 5 | 17 |
2017 Junio | 12 | 6 | 18 |
2017 Mayo | 15 | 4 | 19 |
2017 Abril | 21 | 6 | 27 |
2017 Marzo | 12 | 3 | 15 |
2017 Febrero | 13 | 5 | 18 |
2017 Enero | 9 | 10 | 19 |
2016 Diciembre | 9 | 5 | 14 |
2016 Noviembre | 10 | 3 | 13 |
2016 Octubre | 14 | 5 | 19 |
2016 Septiembre | 26 | 2 | 28 |
2016 Agosto | 41 | 0 | 41 |
2016 Julio | 52 | 1 | 53 |
2016 Junio | 50 | 0 | 50 |
2016 Mayo | 51 | 0 | 51 |
2016 Abril | 32 | 0 | 32 |
2016 Marzo | 28 | 0 | 28 |
2016 Febrero | 39 | 0 | 39 |
2016 Enero | 38 | 0 | 38 |
2015 Diciembre | 51 | 0 | 51 |
2015 Noviembre | 46 | 0 | 46 |
2015 Octubre | 39 | 0 | 39 |
2015 Septiembre | 27 | 0 | 27 |
2015 Agosto | 52 | 0 | 52 |
2015 Julio | 21 | 0 | 21 |
2015 Junio | 22 | 0 | 22 |
2015 Mayo | 16 | 0 | 16 |
2015 Abril | 6 | 0 | 6 |