Estadísticas

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      "titulo" => "Interrelaciones entre angiotensina II, catecolaminas, tromboxano A2, y endotelina-1 en la regulación de la resistencia renal en ratas hipertensas"
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          "autoresLista" => "E. CEDIEL , S. VÁZQUEZ-PÉREZ , N. DE LAS HERAS , D. SANZ-ROSA , V. CACHOFEIRO , V. LAHERA"
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    "titulo" => "Comparative effects of ACE inhibition of angiotensin II receptor blockade in prevention of renal damage"
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    "textoCompleto" => "NEFROLOG&#205;A&#46; Vol&#46; XXII&#46; Suplemento 2&#46; 2002 Comparative effects of ACE inhibition and angiotensin II receptor blockade in prevention of renal damage S&#46; Klahr&#44; M&#46;D&#46; Washington University in St&#46; Louis&#46; Missouri&#46; USA&#46; Intrarenal angiotensin II has important effects on renal function and urinary sodium excretion and&#44; via these local actions&#44; on blood pressure regulation&#46; Angiotensin-converting enzyme inhibitor &#40;ACE I&#41; treatment has been found to be renoprotective in patients with a variety of chronic renal diseases and also in diabetic patients with nephropathy&#46; Although both ACE I and angiotensin subtype 1 receptor antagonists &#40;AT1 RA&#41; are effective in inhibiting renin-angiotensin system &#40;RAS&#41;&#44; they differ in their effects on the components of the system&#46; Inhibition of ACE results in decreased conversiion of Ang I to Ang II and a compensatory rise in renin levels due to loss of negative feedback inhibition by juxtaglomerular apparatus cells &#40;JGA&#41;&#46; In contrast AT1 RA produce elevation in both renin and Ang II because normal feedback inhibition of JGA cells through stimulation of angiotensin II type 1 &#40;AT1&#41; receptors in blocked&#46; These differences in the level of inhibition may have impli- cations for the therapeutic effects of AT1 RA as compared to ACE I&#46; ACE I reduces only ACE dependent Ang II production&#44; whereas AT1 RA blocks the effect of Ang II from any source at the receptor level&#46; In the presence of ACE inhibition Ang II may be produced by other proteases&#44; including chymese and other serine proteases&#46; It is known that there are at least two subtypes of AT receptors&#46; Blockade of the AT1 receptors in the presence of Ang II levels may result in stimulation of subtype 2 &#40;AT2&#41; receptors&#46; AT1 receptors mediate most of the known effects of Ang II such as vasoconstriction&#44; upregulation of aldosterone synthesis and its release&#44; and renal tubule sodium and water reabsorption&#46; Most of the studies in models of chronic renal disease indicate that treatment with AT1 RA affords renal protection that is comparable to that observed with ACE inhibition&#46; 4 "
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