se ha leído el artículo
array:19 [ "pii" => "X0211699502027873" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2002-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2002;22 Supl 2:13" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2437 "formatos" => array:3 [ "EPUB" => 195 "HTML" => 1935 "PDF" => 307 ] ] "itemSiguiente" => array:15 [ "pii" => "X0211699502027865" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2002-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2002;22 Supl 2:14" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2870 "formatos" => array:3 [ "EPUB" => 188 "HTML" => 2226 "PDF" => 456 ] ] "es" => array:8 [ "idiomaDefecto" => true "titulo" => "Homocisteína, hipertensión arterial y genes" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "14" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. C. RODRIGUEZ PÉREZ" "autores" => array:1 [ 0 => array:1 [ "nombre" => "J. C. RODRIGUEZ PÉREZ" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699502027865?idApp=UINPBA000064" "url" => "/02116995/00000022000000S2/v0_201502091327/X0211699502027865/v0_201502091327/es/main.assets" ] "itemAnterior" => array:15 [ "pii" => "X0211699502027881" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2002-04-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2002;22 Supl 2:12" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1532 "formatos" => array:3 [ "EPUB" => 181 "HTML" => 1026 "PDF" => 325 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Effects of AT1 blockade on myocardial fibrosis in hypertensive heart disease. Beyond the control of blood pressure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "12" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. DÍEZ" "autores" => array:1 [ 0 => array:1 [ "nombre" => "J. DÍEZ" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699502027881?idApp=UINPBA000064" "url" => "/02116995/00000022000000S2/v0_201502091327/X0211699502027881/v0_201502091327/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Large artery damage and hypertension in end-stage renal failure (ESRD)" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "13" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "G. M. LONDON" "autores" => array:1 [ 0 => array:1 [ "nombre" => "G. M. LONDON" ] ] ] ] "textoCompleto" => "NEFROLOGÍA. Vol. XXII. Suplemento 2. 2002 Large artery damage and hypertension in end-stage renal failure (ESRD) G. M. London Hospital Manhes, Fleury Mérogis. France. The ill effects of hypertension are attributed to reduction in the caliber or the number of arterioles, resulting in increased total peripheral resistance (TPR). TPR is a determinant of mean arterial pressure (MBP) considered as constant over time. This does not take into account the fact that BP is an oscillatory phenomenon with systolic and diastolic BP being the limits of these oscillations. Moreover, while MBP and diastolic BP are almost constant along the arterial tree, systolic BP is amplified from the aorta to the brachial artery whose systolic BP only indirectly reflects the pressure in the aorta and LV1. The appropriate term to define the arterial factor(s) opposing LV ejection is aortic input impedance which depends on TPR, arterial compliance, wave reflections, and inertance of blood column in the arterial tree. Arterial compliance and wave reflections are major determinants of systolic and diastolic BP, and the pressure wave amplitude, i.e. pulse pressure (PP) which is an independent cardiovascular risk factor. ALTERATIONS OF AORTIC INPUT IMPEDANCE IN ESRD AND ITS CONSEQUENCES Due to anemia or arteriovenous shunts, TPR is usually within normal values in ESRD patients. The aortic impedance is increased principally due to decreased arterial compliance (arterial stiffening), increased wave reflections and higher inertance 2, 3. In ESRD changes in compliance are associated with arterial remodelling, pricipally intima-media thickening and the enlargement of arterial lumen 3. The enlargement of the arteries increases the volume and mass of blood contained in the arterial tree and is responsible for increased inertance. The increased stiffness ins renal failure is due to alterations of biomaterials characterized by increased elastic modulus (Einc) 4 associated with arterial mediacalcosis, and low-grade inflammation. Besides arterial sitffness, early wave reflections represents major contribution to LV afterload and compromised coronary perfusion 1. Wave reflections are frequently increased in es- sential hypertension and almost constantly increased in ESRD 2, 3. The arterial stiffening estimated by changes in aortic pulse wave velocity is an independent predictor of survival in ESRD and general population5-6. Increased wave reflections independently from changes in arterial stiffness are also a strong predictor of survival in ESRD patients 7. Improvement of arterial compliance and decrease in the effect of wave reflections could be obtained by antihypertensive treatment as observed with the calcium-channel blocker and ACE inhibitors 8. It has been shown that improvement of aortic compliance and use of ACE inhibitors had favorable independent effect on survival in hypertensive patients with ESRD 9. REFERENCES 1. Nichols WW, O'Rourke MF: McDonald's blood flow in arteries: theoretical, experimental and clinical principles (4th edn.). Edward Arnold, London, 1998. 2. Safar ME, London GM: The arterial system in human hypertension. In: Textbook of Hypertension (ed. Swales JD). London: Blackwell Scientific. 1994. p. 85-102. 3. London GM, Guérin AP, Marchais SJ y cols.: Cardiac and arterial interactions in end-stage renal disease. Kidney Int 50: 600-8, 1996. 4. Mourad JJ, Girerd X, Boutouyrie P y cols.: Increases stiffness of radial artery wall material in end-stage renal disease. Hypertesion 30: 1425-30, 1997. 5. Blacher J, Guérin AP, Pannier B y cols.: Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99: 2434-2439, 1999. 6. Laurent S, Boutouyrie P, Asmar R y cols.: Aortic sitffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236-41, 2001. 7. London GM, Blacher J, Pannier B y cols.: Arterial wave reflections and survival in end-stage renal failure. Hypertension 38: 434-438, 2001. 8. London GM, Pannier B, Guerin AP y cols.: Cardiac hypertrophy, aortic compliance, peripheral resistance and wave reflection in end-stage renal disease: comparative effects of ACE inhibition and calcium channel blockade. Circulation 90: 2786-96, 1994. 9. Guérin AP, Blacher J, Pannier B y cols.: Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 103: 987-92, 2001. 13 " "pdfFichero" => "P7-E193-S140-A3681.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/02116995/00000022000000S2/v0_201502091327/X0211699502027873/v0_201502091327/en/main.assets" "Apartado" => array:4 [ "identificador" => "35407" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Suplementos" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/00000022000000S2/v0_201502091327/X0211699502027873/v0_201502091327/en/P7-E193-S140-A3681.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699502027873?idApp=UINPBA000064" ]
Idioma original: Inglés
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 5 | 6 | 11 |
2024 Octubre | 29 | 37 | 66 |
2024 Septiembre | 25 | 30 | 55 |
2024 Agosto | 39 | 68 | 107 |
2024 Julio | 32 | 32 | 64 |
2024 Junio | 49 | 39 | 88 |
2024 Mayo | 47 | 29 | 76 |
2024 Abril | 35 | 25 | 60 |
2024 Marzo | 24 | 24 | 48 |
2024 Febrero | 31 | 45 | 76 |
2024 Enero | 20 | 31 | 51 |
2023 Diciembre | 31 | 25 | 56 |
2023 Noviembre | 39 | 36 | 75 |
2023 Octubre | 55 | 44 | 99 |
2023 Septiembre | 48 | 29 | 77 |
2023 Agosto | 26 | 10 | 36 |
2023 Julio | 19 | 46 | 65 |
2023 Junio | 30 | 16 | 46 |
2023 Mayo | 34 | 27 | 61 |
2023 Abril | 20 | 18 | 38 |
2023 Marzo | 16 | 17 | 33 |
2023 Febrero | 25 | 26 | 51 |
2023 Enero | 29 | 22 | 51 |
2022 Diciembre | 42 | 34 | 76 |
2022 Noviembre | 35 | 29 | 64 |
2022 Octubre | 34 | 36 | 70 |
2022 Septiembre | 43 | 23 | 66 |
2022 Agosto | 38 | 39 | 77 |
2022 Julio | 43 | 38 | 81 |
2022 Junio | 32 | 19 | 51 |
2022 Mayo | 37 | 31 | 68 |
2022 Abril | 21 | 33 | 54 |
2022 Marzo | 24 | 27 | 51 |
2022 Febrero | 23 | 26 | 49 |
2022 Enero | 31 | 26 | 57 |
2021 Diciembre | 21 | 29 | 50 |
2021 Noviembre | 30 | 28 | 58 |
2021 Octubre | 26 | 39 | 65 |
2021 Septiembre | 20 | 20 | 40 |
2021 Agosto | 22 | 30 | 52 |
2021 Julio | 25 | 31 | 56 |
2021 Junio | 12 | 15 | 27 |
2021 Mayo | 21 | 27 | 48 |
2021 Abril | 41 | 38 | 79 |
2021 Marzo | 31 | 14 | 45 |
2021 Febrero | 10 | 24 | 34 |
2021 Enero | 17 | 11 | 28 |
2020 Diciembre | 18 | 9 | 27 |
2020 Noviembre | 18 | 11 | 29 |
2020 Octubre | 14 | 9 | 23 |
2020 Septiembre | 7 | 3 | 10 |
2020 Agosto | 23 | 10 | 33 |
2020 Julio | 13 | 12 | 25 |
2020 Junio | 23 | 17 | 40 |
2020 Mayo | 22 | 10 | 32 |
2020 Abril | 22 | 14 | 36 |
2020 Marzo | 33 | 10 | 43 |
2020 Febrero | 25 | 18 | 43 |
2020 Enero | 30 | 18 | 48 |
2019 Diciembre | 16 | 11 | 27 |
2019 Noviembre | 16 | 7 | 23 |
2019 Octubre | 686 | 7 | 693 |
2019 Septiembre | 19 | 8 | 27 |
2019 Agosto | 4 | 8 | 12 |
2019 Julio | 12 | 9 | 21 |
2019 Junio | 16 | 8 | 24 |
2019 Mayo | 6 | 8 | 14 |
2019 Abril | 27 | 24 | 51 |
2019 Marzo | 11 | 11 | 22 |
2019 Febrero | 7 | 11 | 18 |
2019 Enero | 17 | 6 | 23 |
2018 Diciembre | 24 | 24 | 48 |
2018 Noviembre | 47 | 7 | 54 |
2018 Octubre | 38 | 11 | 49 |
2018 Septiembre | 19 | 5 | 24 |
2018 Agosto | 10 | 7 | 17 |
2018 Julio | 12 | 5 | 17 |
2018 Junio | 18 | 6 | 24 |
2018 Mayo | 17 | 9 | 26 |
2018 Abril | 14 | 4 | 18 |
2018 Marzo | 8 | 4 | 12 |
2018 Febrero | 12 | 3 | 15 |
2018 Enero | 7 | 6 | 13 |
2017 Diciembre | 12 | 5 | 17 |
2017 Noviembre | 9 | 4 | 13 |
2017 Octubre | 13 | 3 | 16 |
2017 Septiembre | 5 | 1 | 6 |
2017 Agosto | 16 | 6 | 22 |
2017 Julio | 13 | 4 | 17 |
2017 Junio | 20 | 13 | 33 |
2017 Mayo | 18 | 4 | 22 |
2017 Abril | 15 | 1 | 16 |
2017 Marzo | 12 | 1 | 13 |
2017 Febrero | 5 | 2 | 7 |
2017 Enero | 6 | 4 | 10 |
2016 Diciembre | 18 | 6 | 24 |
2016 Noviembre | 19 | 7 | 26 |
2016 Octubre | 37 | 5 | 42 |
2016 Septiembre | 33 | 5 | 38 |
2016 Agosto | 84 | 1 | 85 |
2016 Julio | 62 | 0 | 62 |
2016 Junio | 80 | 0 | 80 |
2016 Mayo | 70 | 0 | 70 |
2016 Abril | 30 | 0 | 30 |
2016 Marzo | 24 | 0 | 24 |
2016 Febrero | 34 | 0 | 34 |
2016 Enero | 21 | 0 | 21 |
2015 Diciembre | 30 | 0 | 30 |
2015 Noviembre | 20 | 0 | 20 |
2015 Octubre | 32 | 0 | 32 |
2015 Septiembre | 29 | 0 | 29 |
2015 Agosto | 19 | 0 | 19 |
2015 Julio | 26 | 0 | 26 |
2015 Junio | 7 | 0 | 7 |
2015 Mayo | 12 | 0 | 12 |