se ha leído el artículo
array:19 [ "pii" => "X0211699500025928" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2000-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2000;20 Supl 1:6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1795 "formatos" => array:3 [ "EPUB" => 155 "HTML" => 1365 "PDF" => 275 ] ] "itemSiguiente" => array:15 [ "pii" => "X021169950002591X" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2000-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2000;20 Supl 1:7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9622 "formatos" => array:3 [ "EPUB" => 166 "HTML" => 8424 "PDF" => 1032 ] ] "es" => array:8 [ "idiomaDefecto" => true "titulo" => "«FISIOPATOLOGÍA VASCULAR EN LA HIPERTENSIÓN ARTERIAL» Disfunción endotelial y daño vascular" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "7" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. CEDIEL , S. VÁZQUEZ-PÉREZ , N. DE LAS HERAS , V. CACHOFEIRO , V. LAHERA , J. NAVARRO-CID" "autores" => array:1 [ 0 => array:1 [ "nombre" => "E. CEDIEL , S. VÁZQUEZ-PÉREZ , N. DE LAS HERAS , V. CACHOFEIRO , V. LAHERA , J. NAVARRO-CID" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X021169950002591X?idApp=UINPBA000064" "url" => "/02116995/00000020000000S1/v0_201502091333/X021169950002591X/v0_201502091333/es/main.assets" ] "itemAnterior" => array:15 [ "pii" => "X0211699500025936" "issn" => "02116995" "estado" => "S300" "fechaPublicacion" => "2000-02-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2000;20 Supl 1:5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1494 "formatos" => array:3 [ "EPUB" => 152 "HTML" => 1098 "PDF" => 244 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Nitric Oxide: Biological Relevance" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "5" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. MONCADA" "autores" => array:1 [ 0 => array:1 [ "nombre" => "S. MONCADA" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699500025936?idApp=UINPBA000064" "url" => "/02116995/00000020000000S1/v0_201502091333/X0211699500025936/v0_201502091333/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "Effects of Nitric Oxide Synthase (NOS), Blockers on Renal Function" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "6" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. B. GABBAI" "autores" => array:1 [ 0 => array:1 [ "nombre" => "F. B. GABBAI" ] ] ] ] "textoCompleto" => "NEFROLOGÍA. Vol. XX. Suplemento 1. 2000 Effects of Nitric Oxide Synthase (NOS) Blockers on Renal Function Francis B. Gabbai Over the past 10 years, NOS blockers have been utilized as a major tool to define the role of NO in renal physiology and pathophysiology. Three types of NOS isoforms, neuronal NOS (bNOS), inducible NOS (iNOS) and endothelial NOS (eNOS) are expressed in the different structures of the kidney. The use of more selective NOS blockers has helped our understanding of the function of each one of the three isoforms in various renal physiologic functions. Studies from our and other laboratories several years ago revealed that administration of non specific NOS blockers (LNMMA) increased systemic blood pressure and modified renal function. At the single nephron level, LNMMA produced a reduction in nephron filtration rate secondary to reductions in both the ultrafiltration coefficient and nephron plasma flow, the later due to increased afferent and efferent glomerular arteriolar resistances. Studies utilizing angiotensin II receptor blockers revealed that AII blockade suppressed the effect of L-NMMA on efferent arteriolar resistance and ultrafiltration coefficient suggesting the presence of an important interaction between NO and AII in the control of renal hemodynamics. L-NMMA also decreased proximal tubular reabsorption, an effect also abrogated by AII blockade. Follow up studies in our laboratory looking at the interaction between NO and AII demonstrated that administration of non specific NOS blockers (L-NMMA or L-NAME) led to a dissociation between plasma and kidney tissue AII levels where LNMMA reduced significantly plasma AII levels without modifying kidney AII concentrations. The mechanism responsible for this dissociation remains ill defined but these findings explain the beneficial effects of AII blockade on renal function in the absence of an antihypertensive effect in L-NNMA treated rats. Studies in our laboratory went on to investigate the presence of an interaction between the renal adrenergic system and NO based on our previous findings of renal adrenergic system-AII interaction. Our results demonstrate that renal denervation prevents most of the effects of L-NMMA on glomerular hemodynamics (reduced ultrafiltration coefficient and increased efferent resistance) and tubular function (reduction in proximal reabsorption). Follow up studies in denervated rats revealed that administration of an 2adrenergic receptor agonist restored the glomerular and tubular response to L-NMMA suggesting the presence of an important interaction between AII, renal adrenergic system and NO in the control of normal renal function. Neuronal NOS is mainly located at the level of the macula densa where NO derived from this enzyme modulates activity of the tubuloglomerular feedback system. We recently investigated the role of neuronal NOS in diabetes-induced hyperfiltration using bNOS blockers. These agents selectively reduced GFR in diabetic rats suggesting that hyperfiltration and decreased tubuloglomerular feedback activity observed in experimental diabetes are mediated by increased bNOS activity. Interestingly, combining bNOS blockers and L-NMMA did not produce any further change in GFR implying that correction of diabetic hyperfiltration with L-NMMA depends on increased bNOS activity and not eNOS as previously suggested. Our group has also examined the role of iNOS in various renal disease models, including LPS and autoimmune tubulointerstitial nephritis. Both conditions are characterized by significant baseline reductions in GFR and improvement in GFR after administration of iNOS blockers. This unexpected finding where too much NO may be as deleterious as very little NO for kidney function seems rather peculiar to the kidney. It suggests however the presence of highly complex interactions between the three different NOS isoforms with potential autoinhibition phenomenom and between NO and the renal neurohumoral system. 6 " "pdfFichero" => "P7-E170-S140-A2005.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/02116995/00000020000000S1/v0_201502091333/X0211699500025928/v0_201502091333/en/main.assets" "Apartado" => array:4 [ "identificador" => "35407" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Suplementos" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/00000020000000S1/v0_201502091333/X0211699500025928/v0_201502091333/en/P7-E170-S140-A2005.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699500025928?idApp=UINPBA000064" ]
Idioma original: Inglés
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 5 | 10 | 15 |
2024 Octubre | 41 | 34 | 75 |
2024 Septiembre | 40 | 34 | 74 |
2024 Agosto | 43 | 51 | 94 |
2024 Julio | 39 | 30 | 69 |
2024 Junio | 50 | 30 | 80 |
2024 Mayo | 78 | 32 | 110 |
2024 Abril | 36 | 24 | 60 |
2024 Marzo | 44 | 26 | 70 |
2024 Febrero | 62 | 36 | 98 |
2024 Enero | 37 | 19 | 56 |
2023 Diciembre | 42 | 20 | 62 |
2023 Noviembre | 45 | 28 | 73 |
2023 Octubre | 22 | 32 | 54 |
2023 Septiembre | 26 | 19 | 45 |
2023 Agosto | 30 | 22 | 52 |
2023 Julio | 32 | 20 | 52 |
2023 Junio | 30 | 18 | 48 |
2023 Mayo | 43 | 27 | 70 |
2023 Abril | 18 | 16 | 34 |
2023 Marzo | 16 | 15 | 31 |
2023 Febrero | 16 | 24 | 40 |
2023 Enero | 25 | 22 | 47 |
2022 Diciembre | 30 | 27 | 57 |
2022 Noviembre | 24 | 23 | 47 |
2022 Octubre | 26 | 32 | 58 |
2022 Septiembre | 33 | 26 | 59 |
2022 Agosto | 34 | 36 | 70 |
2022 Julio | 27 | 37 | 64 |
2022 Junio | 24 | 29 | 53 |
2022 Mayo | 20 | 26 | 46 |
2022 Abril | 36 | 42 | 78 |
2022 Marzo | 29 | 41 | 70 |
2022 Febrero | 36 | 29 | 65 |
2022 Enero | 37 | 25 | 62 |
2021 Diciembre | 22 | 34 | 56 |
2021 Noviembre | 27 | 19 | 46 |
2021 Octubre | 32 | 40 | 72 |
2021 Septiembre | 19 | 30 | 49 |
2021 Agosto | 31 | 35 | 66 |
2021 Julio | 22 | 26 | 48 |
2021 Junio | 19 | 18 | 37 |
2021 Mayo | 23 | 24 | 47 |
2021 Abril | 26 | 70 | 96 |
2021 Marzo | 29 | 14 | 43 |
2021 Febrero | 39 | 16 | 55 |
2021 Enero | 15 | 12 | 27 |
2020 Diciembre | 23 | 14 | 37 |
2020 Noviembre | 23 | 10 | 33 |
2020 Octubre | 12 | 8 | 20 |
2020 Septiembre | 11 | 3 | 14 |
2020 Agosto | 24 | 9 | 33 |
2020 Julio | 28 | 10 | 38 |
2020 Junio | 20 | 9 | 29 |
2020 Mayo | 27 | 10 | 37 |
2020 Abril | 25 | 9 | 34 |
2020 Marzo | 16 | 10 | 26 |
2020 Febrero | 27 | 11 | 38 |
2020 Enero | 47 | 12 | 59 |
2019 Diciembre | 22 | 9 | 31 |
2019 Noviembre | 18 | 3 | 21 |
2019 Octubre | 13 | 9 | 22 |
2019 Septiembre | 11 | 10 | 21 |
2019 Agosto | 7 | 11 | 18 |
2019 Julio | 18 | 11 | 29 |
2019 Junio | 14 | 4 | 18 |
2019 Mayo | 14 | 5 | 19 |
2019 Abril | 29 | 21 | 50 |
2019 Marzo | 30 | 11 | 41 |
2019 Febrero | 9 | 12 | 21 |
2019 Enero | 12 | 10 | 22 |
2018 Diciembre | 24 | 16 | 40 |
2018 Noviembre | 26 | 7 | 33 |
2018 Octubre | 23 | 10 | 33 |
2018 Septiembre | 18 | 4 | 22 |
2018 Agosto | 18 | 9 | 27 |
2018 Julio | 15 | 7 | 22 |
2018 Junio | 18 | 6 | 24 |
2018 Mayo | 19 | 5 | 24 |
2018 Abril | 19 | 6 | 25 |
2018 Marzo | 15 | 3 | 18 |
2018 Febrero | 21 | 4 | 25 |
2018 Enero | 8 | 6 | 14 |
2017 Diciembre | 23 | 4 | 27 |
2017 Noviembre | 17 | 3 | 20 |
2017 Octubre | 16 | 6 | 22 |
2017 Septiembre | 4 | 0 | 4 |
2017 Agosto | 22 | 9 | 31 |
2017 Julio | 12 | 5 | 17 |
2017 Junio | 12 | 10 | 22 |
2017 Mayo | 13 | 1 | 14 |
2017 Abril | 10 | 2 | 12 |
2017 Marzo | 8 | 1 | 9 |
2017 Febrero | 4 | 0 | 4 |
2017 Enero | 0 | 1 | 1 |
2016 Diciembre | 16 | 4 | 20 |
2016 Noviembre | 23 | 1 | 24 |
2016 Octubre | 39 | 6 | 45 |
2016 Septiembre | 37 | 2 | 39 |
2016 Agosto | 54 | 3 | 57 |
2016 Julio | 63 | 4 | 67 |
2016 Junio | 45 | 0 | 45 |
2016 Mayo | 69 | 0 | 69 |
2016 Abril | 53 | 0 | 53 |
2016 Marzo | 27 | 0 | 27 |
2016 Febrero | 29 | 0 | 29 |
2016 Enero | 39 | 0 | 39 |
2015 Diciembre | 53 | 0 | 53 |
2015 Noviembre | 38 | 0 | 38 |
2015 Octubre | 27 | 0 | 27 |
2015 Septiembre | 37 | 0 | 37 |
2015 Agosto | 44 | 0 | 44 |
2015 Julio | 25 | 0 | 25 |
2015 Junio | 13 | 0 | 13 |
2015 Mayo | 13 | 0 | 13 |