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"es" 1 => "en" ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "DIABETIC KIDNEY DISEASE AND POLYMORPHISMS OF THE ELMO1 AND AGTR1 GENES: SYSTEMATIC REVIEW" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yuliana Martínez-Nava, María Camila Ogaz-Escarpita, Sandra Alicia Reza-López, Irene Leal-Berumen" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Yuliana" "apellidos" => "Martínez-Nava" ] 1 => array:2 [ "nombre" => "María Camila" "apellidos" => "Ogaz-Escarpita" ] 2 => array:2 [ "nombre" => "Sandra Alicia" "apellidos" => "Reza-López" ] 3 => array:2 [ "nombre" => "Irene" "apellidos" => "Leal-Berumen" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021169952400095X?idApp=UINPBA000064" "url" => "/02116995/unassign/S021169952400095X/v1_202410180432/es/main.assets" ] "itemAnterior" => array:16 [ "pii" => "S0211699521002150" "issn" => "02116995" "doi" => "10.1016/j.nefro.2021.09.007" "estado" => "S5" "fechaPublicacion" => "2022-10-28" "aid" => "976" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "ret" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "WITHDRAWN: Carta al editor: Factores de riesgo de lesión renal aguda en adultos con covid-19" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Xiaoyue Cai, Guiming Wu, Jie Zhang, Lichuan Yang" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Xiaoyue" "apellidos" => "Cai" ] 1 => array:2 [ "nombre" => "Guiming" "apellidos" => "Wu" ] 2 => array:2 [ "nombre" => "Jie" "apellidos" => "Zhang" ] 3 => array:2 [ "nombre" => "Lichuan" "apellidos" => "Yang" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699521002150?idApp=UINPBA000064" "url" => "/02116995/unassign/S0211699521002150/v2_202302211535/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "titulo" => "Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sebastián Mas-Fontao, Esther Civantos, Nisa Boukichou-Abdelkader, Manuel Soto-Catalan, Marta Romeo-Colas, Arantxa Marco, Carmen Gomez-Guerrero, Juan Antonio Moreno, Jaakko Tuomilehto, Rafael Gabriel, Jesús Egido" "autores" => array:12 [ 0 => array:4 [ "nombre" => "Sebastián" "apellidos" => "Mas-Fontao" "email" => array:1 [ 0 => "smas@fjd.es" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 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array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 11 => array:2 [ "colaborador" => "on behalf of ePREDICE investigators" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:10 [ 0 => array:3 [ "entidad" => "Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Faculty of Medicine and Biomedicine, Universidad Alfonso X el Sabio (UAX), Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "EVIDEM CONSULTORES, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Asociación para la Investigación y Prevención de la Diabetes y Enfermedades Cardiovasculares (PREDICOR), Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Hospital Universitario Reina Sofía, Cordoba, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "World Community for Prevention of Diabetes Foundation (WCPD), Madrid, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Finnish Institute for Health and Welfare, Helsinki, Finland" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Department of Public Health, University of Helsinki, Helsinki, Finland" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Departamento de Salud Internacional, Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-03-22" "fechaAceptado" => "2024-10-10" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1894121" "palabras" => array:5 [ 0 => "Type 2 diabetes" 1 => "Prediabetes" 2 => "Chronic kidney disease" 3 => "Oxidative stress" 4 => "Biomarkers" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Background: Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Methods: In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (Advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein-CRP; Interleukin 6-IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Results: Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Conclusion: These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggest that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Antecedentes: El estudio de los mecanismos implicados en la transición de la prediabetes a la diabetes y sus complicaciones asociadas, como la enfermedad renal, es un tema de gran interés. Este estudio se centra en la identificación de biomarcadores eficaces para la detección precoz de la afectación renal, evaluando moléculas asociadas a estrés oxidativo e inflamación en individuos prediabéticos de de varios países europeos..</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Métodos: En muestras de plasma de individuos prediabéticos, incluidos en el estudio ePREDICE, se determinaron biomarcadores de estrés oxidativo (AOPP) e inflamación (Proteína c-Reactiva, IL-6) y se correlacionaron con datos antropométricos y bioquímicos, evaluando su potencial en el diagnóstico precoz de la disfunción renal</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Resultados: Entre los 967 sujetos con prediabetes, 94 presentaban algún signo de afectación renal, como albuminuria, hiperfiltración o hipofiltración. Se identificaron variaciones significativas entre los biomarcadores de estrés oxidativo e inflamatorios (cuartiles superiores e inferior del AOPP, PCR y IL6) y parámetros relacionados como la presión arterial, el metabolismo glucémico, el perfil lipídico y el índice de hígado graso. En particular, ambos biomarcadores estaban bien relacionados con los componentes del síndrome metabólico. Existieron asociaciones significativas entre la AOPP y la PCR, y la presencia de albuminuria, pero no con la función renal. En general, la PCR fue mejor biomarcador que la IL-6 para la mayoría de los parámetros estudiados</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Conclusiones: Estos resultados subrayan las importantes conexiones entre estrés oxidativo e inflamación con las anomalías metabólicas ligadas al estado prediabético y sus complicaciones como el hígado graso y la afectación renal. Aunque es necesario confirmar estos datos, nuestro estudio sugiere que los AOPP y la PCR podrían ser biomarcadores de interés en la predicción del riesgo de pérdida de función renal en sujetos con prediabetes.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "⁎⁎" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">The list of the ePREDICE investigators at the end of the paper</p>" "identificador" => "fn0005" ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/unassign/S0211699524000973/v1_202410170446/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/02116995/unassign/S0211699524000973/v1_202410170446/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699524000973?idApp=UINPBA000064" ]
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