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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La hipercalciuria &#40;HC&#41;&#44; bien de causa resortiva&#44; absortiva o excretora&#44; constituye una situaci&#243;n de riesgo para la aparici&#243;n de nefrolitiasis&#44; nefrocalcinosis e&#44; incluso&#44; osteoporosis<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">1&#8211;5</span></a>&#46; En la excretora&#44; el tratamiento con tiazidas disminuye la eliminaci&#243;n urinaria de calcio mediante reabsorci&#243;n en el t&#250;bulo proximal<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a>&#46; Una situaci&#243;n similar de la HC ocurre frecuentemente en el tratamiento del hipoparatiroidismo&#44; con el aporte ex&#243;geno de vitamina D y calcio&#59; el calcio se excreta libremente en el ri&#241;&#243;n&#44; ya que ante la ausencia de la parathormona &#40;PTH&#41; desaparece la reabsorci&#243;n tubular ejercida por esta hormona&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; la excreci&#243;n de calcio urinario est&#225; modulada por m&#250;ltiples factores nutricionales como la ingesta alta de prote&#237;nas animales y sal&#44; la calcemia y magnesemia&#44; y el equilibrio &#225;cido-base<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">4&#44;5&#44;7&#8211;12</span></a>&#46; Por tanto&#44; su tratamiento debe incluir modificaciones nutricionales<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">11&#44;12</span></a>&#44; adem&#225;s de la terapia con tiazidas&#46; La restricci&#243;n de la sal en la dieta es un elemento imprescindible en dichos procesos&#46; Queremos cuantificar la correlaci&#243;n entre la natriuria y la calciuria&#44; con una dieta artificial &#40;Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium&#41; e incrementos escalonados de ClNa v&#237;a oral y el tratamiento a&#241;adido de tiazidas con la m&#225;xima dosis de ClNa&#46; Adem&#225;s&#44; valoramos la respuesta aguda de los niveles de actividad renina plasm&#225;tica &#40;ARP&#41; y de aldosterona&#46; As&#237;&#44; pretendemos conocer las correlaciones entre la ingesta de sal&#44; la excreci&#243;n de Na y Ca y&#44; finalmente&#44; las modificaciones a&#241;adidas tras el tratamiento complementario con tiazidas&#44; lo que nos indicar&#225; si es imprescindible disminuir la sal en la dieta&#44; en qu&#233; cuant&#237;a&#44; o si con el tratamiento con tiazidas no es tan importante limitar su ingesta&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Objetivos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Pretendemos valorar la ingesta normal de sal en una poblaci&#243;n masculina&#44; joven&#44; sana&#44; y estudiar la correlaci&#243;n entre el Na y el Ca en orina con la dieta habitual y tras la manipulaci&#243;n de las cantidades de ClNa ingeridas y el tratamiento con tiazidas&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Material y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">A&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall">Sujetos Diecinueve varones sanos&#44; de entre 18 y 30 a&#241;os&#44; talla 178&#44;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;75<span class="elsevierStyleHsp" style=""></span>cm&#59; peso 81&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;8<span class="elsevierStyleHsp" style=""></span>kg e &#237;ndice de masa corporal 25&#44;56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Firmaron el consentimiento informado&#46; No padec&#237;an hipertensi&#243;n arterial&#44; nefrolitiasis&#44; insuficiencia renal&#44; dislipemia ni obesidad&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">B&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Protocolo El estudio se realiz&#243; durante 8 d&#237;as y&#44; en 12 de ellos se prolong&#243; hasta el d&#233;cimo&#46; Se sustituy&#243; su dieta habitual por 2<span class="elsevierStyleHsp" style=""></span>l de Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium&#44; que aporta diariamente 2&#46;000<span class="elsevierStyleHsp" style=""></span>kcal&#44; 1&#46;600<span class="elsevierStyleHsp" style=""></span>mg de calcio&#44; 500<span class="elsevierStyleHsp" style=""></span>mg de Na &#40;equivalentes a 1&#46;250<span class="elsevierStyleHsp" style=""></span>g de ClNa&#41; y cantidades conocidas de macro y micronutrientes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Adem&#225;s&#44; se recomend&#243; la ingesta de 1&#44;5-2<span class="elsevierStyleHsp" style=""></span>l de agua diarios&#46;Los d&#237;as 1&#46;&#176; y 2&#46;&#176; tomaron solamente Nutrison<span class="elsevierStyleSup">&#174;</span>&#46; Los d&#237;as 3&#46;&#176; y 4&#46;&#176; se a&#241;adieron 5<span class="elsevierStyleHsp" style=""></span>g de sal diarios en c&#225;psulas repartidas en 3 tomas&#44; aument&#225;ndose los d&#237;as 5&#46;&#176; y 6&#46;&#176; a 10<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a y los d&#237;as 7&#46;&#176; y 8&#46;&#176;&#44; 15<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#46; Doce prosiguieron el estudio los d&#237;as 9 y 10&#44; continuando diariamente con 2<span class="elsevierStyleHsp" style=""></span>l de Nutrison<span class="elsevierStyleSup">&#174;</span>&#44; 15<span class="elsevierStyleHsp" style=""></span>g de sal y se a&#241;adi&#243; una tiazida &#40;Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#44; 50<span class="elsevierStyleHsp" style=""></span>mg el d&#237;a 9&#46;&#176; y 100<span class="elsevierStyleHsp" style=""></span>mg el 10&#46;&#176; &#40;2 tomas de 50<span class="elsevierStyleHsp" style=""></span>mg&#41;&#46;Se recogi&#243; orina de 24<span class="elsevierStyleHsp" style=""></span>h los d&#237;as &#8722;1&#44; 2&#44; 4&#44; 6&#44; 8&#44; 9 y 10&#44; determin&#225;ndose Na&#44; Ca i&#243;nico&#44; Cl&#44; K y Mg&#46;Se extrajo sangre venosa en ayunas los d&#237;as 1&#44; 3&#44; 5&#44; 7&#44; 9 y 11&#46; Se determin&#243; Na&#44; Ca&#43;&#43;&#44; Cl&#44; P&#44; Mg&#44; K&#44; Cr&#44; ARP y aldosterona&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">C&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">Estad&#237;stica Se calcul&#243; la media y desviaci&#243;n est&#225;ndar de los grupos&#46; Para comparar las diferentes medias se utiliz&#243; la prueba de Wilcoxon y para estudiar la asociaci&#243;n entre pares de variables se us&#243; la correlaci&#243;n lineal de Pearson&#46; Se fij&#243; un nivel de significaci&#243;n estad&#237;stica del 95&#37;&#46;</p></li></ul></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0040" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">a&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Excreci&#243;n urinaria los d&#237;as &#8722;1 &#40;&#171;B&#187;&#58; dieta libre&#44; previa al estudio&#41;&#59; 2&#46;&#176; &#40;1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; &#171;0&#187;&#41;&#44; 4&#46;&#176; &#40;6&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; &#171;5&#187;&#41;&#44; 6&#46;&#176; &#40;11&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; &#171;10&#187;&#41; y 8&#46;&#176; &#40;16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; &#171;15&#187;&#41;&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;Na &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Respecto a la basal&#44; la natriuria disminuye en &#171;0&#187; y &#171;5&#187;&#44; alcanzando el nivel m&#225;s bajo&#46; Con el incremento de la ingesta de sal&#44; aumenta la natriuria&#46; La diferencia de excreci&#243;n es estad&#237;sticamente significativa &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41; entre todos los valores&#44; excepto entre la basal con &#171;15&#187; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Teniendo en cuenta la cantidad de Na&#44; puesto que el Nutrison<span class="elsevierStyleSup">&#174;</span> contiene 500<span class="elsevierStyleHsp" style=""></span>mg de Na&#44; equivalentes a 1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; asumimos que la ingesti&#243;n es de 1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa con Nutrison<span class="elsevierStyleSup">&#174;</span>&#46; Con estos datos obtenemos la cantidad de sal ingerida &#40;c&#225;lculo respecto al sodio ingerido&#41;&#58; desconocida &#40;&#171;B&#187;&#41;&#59; 1&#44;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#171;0&#187;&#41;&#59; 6&#44;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#171;5&#187;&#41;&#59; 11&#44;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#171;10&#187;&#41;&#59; 16&#44;25<span class="elsevierStyleHsp" style=""></span>g &#40;&#171;15&#187;&#41;&#46; La excreci&#243;n de Na corresponde&#44; respecto a la ingesta de sal&#58; desconocida &#40;&#171;B&#187;&#41;&#59; 276<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>144&#37; &#40;&#171;0&#187;&#41;&#59; 39&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;7&#37; &#40;&#171;5&#187;&#41;&#59; 69&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>25&#44;7&#37; &#40;&#171;10&#187;&#41;&#59; 79&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#37; &#40;&#171;15&#187;&#41;&#46; A partir de estos datos&#44; se puede concluir que la ingesta de sal con la dieta basal es del orden de 15&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;33<span class="elsevierStyleHsp" style=""></span>g&#46;Ca &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Hay aumento estad&#237;sticamente significativo entre &#171;0&#187; y &#171;15&#187;&#44; &#171;5&#187; y &#171;10&#187;&#44; &#171;5&#187; y &#171;15&#187;&#44; y &#171;10&#187; y &#171;15&#187; &#40;todas con p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;Correlaci&#243;n entre Ca y Na en orina de 24<span class="elsevierStyleHsp" style=""></span>h&#46; No hay correlaci&#243;n de estos 2 par&#225;metros con la dieta libre &#171;B&#187; ni en &#171;0&#187; ni en &#171;5&#187;&#46; Hay correlaci&#243;n en &#171;10&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;47&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41; y en &#171;15&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;67&#59; p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Un aumento de ClNa en la dieta de 10<span class="elsevierStyleHsp" style=""></span>g&#44; desde los 6&#44;25<span class="elsevierStyleHsp" style=""></span>g hasta los 16&#44;25<span class="elsevierStyleHsp" style=""></span>g&#44; incrementa la natriuria 182&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>66&#44;4 mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h y la calciuria 54&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>39&#44;4<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;1<span class="elsevierStyleHsp" style=""></span>g de ClNa incrementa 5&#44;46<span class="elsevierStyleHsp" style=""></span>mg de calciuria&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;Cl &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Con el incremento de la ingesta de sal&#44; aumenta la excreci&#243;n de Cl&#46; La diferencia es significativa entre todos los valores&#44; excepto entre la basal con 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal&#46;Las modificaciones en la excreci&#243;n de ClNa&#44; Mg y K se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">b&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Excreci&#243;n urinaria el d&#237;a 9&#46;&#176;&#44; con ingesta de 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal &#40;&#171;15bis&#187;&#41; y 50<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a de Higrotona<span class="elsevierStyleSup">&#174;</span> &#40;&#171;T1&#187;&#41; y el d&#237;a 10&#46;&#176;&#44; con 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal y 50<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#47;12<span class="elsevierStyleHsp" style=""></span>h &#40;&#171;T2&#187;&#41;&#44; n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;Se objetiva un aumento de la excreci&#243;n de Na&#44; Cl&#44; ClNa y Mg con el tratamiento diur&#233;tico&#44; sin diferencias entre las dosis de Higrotona<span class="elsevierStyleSup">&#174;</span>&#46; Con respecto a la calciuria&#44; con 50<span class="elsevierStyleHsp" style=""></span>mg de tiazida &#40;&#171;T1&#187;&#41; no hay cambios respecto a &#171;15bis&#187; y con 100<span class="elsevierStyleHsp" style=""></span>mg hay una disminuci&#243;n significativa&#44; tanto desde &#171;15bis&#187; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41; como desde &#171;T1&#187; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; El decremento tras 100<span class="elsevierStyleHsp" style=""></span>mg de tiazida es de 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> se refleja c&#243;mo con la restricci&#243;n de sal en la dieta disminuye la natriuria y la calciuria&#44; observ&#225;ndose los pacientes en la zona inferior e izquierda del gr&#225;fico&#44; y tras la adici&#243;n de la tiazida disminuye la calciuria aumentando el sodio en orina&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">c&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Modificaci&#243;n de los niveles plasm&#225;ticos de iones con la ingesta de sal y el tratamiento con tiazidas &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;El sodio plasm&#225;tico es normal en todas las determinaciones&#46; El valor m&#225;s bajo de calcio i&#243;nico se obtiene en &#171;5&#187;&#44; con diferencia estad&#237;sticamente significativa con el basal &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41; y &#171;10&#187; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#46; Entre el resto de muestras no hay diferencias significativas&#46;Tras la administraci&#243;n de 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; se objetiva una disminuci&#243;n de Na &#40;p0&#44;001&#41;&#44; Cl &#40;p0&#44;00001&#41; y K &#40;p0&#44;01&#41;&#44; con aumento de p &#40;p0&#44;004&#41;&#44; sin diferencias en los niveles de calcio i&#243;nico y Mg&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">d&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Niveles plasm&#225;ticos de ARP y aldosterona&#46;ARP &#40;ng&#47;ml&#47;h&#41;&#46; Hay un considerable incremento desde &#171;B&#187; hasta &#171;5&#187;&#44; fren&#225;ndose su secreci&#243;n con las dosis crecientes de ClNa&#46; Tras administrar 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span> se observa un considerable incremento &#40;p0&#44;0006&#41; comparado con la ingesta de 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal &#40;&#171;15bis&#187;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;Aldosterona &#40;pg&#47;ml&#41;&#46; Con 10<span class="elsevierStyleHsp" style=""></span>g los valores son similares a los basales y con 15<span class="elsevierStyleHsp" style=""></span>g disminuyen&#44; con un notable aumento tras tiazida &#40;p0&#44;0007&#41;&#46;En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se representa la evoluci&#243;n de la natriuria y de la aldosteronemia&#44; con una perfecta imagen especular&#46; Se aprecia que cuando la natriuria baja&#44; por ingesta escasa de Na&#44; se incrementa la secreci&#243;n de aldosterona&#44; y con las dosis altas de sal aumenta la natriuria y se frena la aldosterona&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discusi&#243;n</span><p id="par0065" class="elsevierStylePara elsevierViewall">Uno de los par&#225;metros m&#225;s importantes en la regulaci&#243;n de la calciuria es la excreci&#243;n de Na<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2&#44;5</span></a> que&#44; a su vez&#44; depende estrechamente de la ingesta de sal&#46; El Na y el Ca se reabsorben conjuntamente en la nefrona proximal&#44; en la porci&#243;n ascendente del asa de Henle y en la nefrona distal&#44; de manera que si aumenta la natriuria&#44; tambi&#233;n la calciuria<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Hay estudios en los que se ha analizado la correlaci&#243;n entre el Na y el Ca&#44; durante la ingesta de la dieta habitual de los sujetos incluidos<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">14&#44;15</span></a>&#44; y otros en los que se ha modificado la ingesta de sal para evaluar su influencia sobre la calciuria<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#44;16</span></a>&#44; pero solamente con una dosis muy baja de Na y otra muy alta&#46; Nuestro estudio es el primero en el que&#44; partiendo de 1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa se eval&#250;a la respuesta con dosis crecientes de sal&#44; introduciendo a continuaci&#243;n la variable de la tiazida&#46; Tambi&#233;n se ha estudiado el problema con modificaciones de las cantidades ingeridas de calcio&#46; La ingesta baja de calcio incrementa la PTH&#44; lo que puede disminuir la masa &#243;sea y mantener o incrementar la calciuria<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a>&#46; Por tanto&#44; lo ideal en la realizaci&#243;n de estos estudios es que la ingesta de calcio no sea deficitaria&#46; En nuestra opini&#243;n&#44; los estudios realizados tienen ciertas limitaciones&#44; por varias razones&#46; En primer lugar&#44; en los estudios con la dieta habitual&#44; ocurre una gran heterogeneidad en los h&#225;bitos nutricionales entre los sujetos&#46; Incluso cuando se ha administrado una dieta elaborada en cuanto a calor&#237;as y contenidos conocidos de macro y micronutrientes<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">17&#44;18</span></a>&#44; sigue existiendo la variabilidad de los alimentos seg&#250;n su procedencia&#44; manipulaci&#243;n&#44; elaboraci&#243;n&#8230; Nuestro m&#233;todo de suministrar una dieta artificial oral l&#237;quida&#44; hace que las cantidades ingeridas sean conocidas y siempre iguales&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En la mayor&#237;a de estudios transversales hay correlaci&#243;n entre la natriuria y la calciuria<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">2&#44;10&#44;19</span></a>&#44; aunque otros no encuentran esa correlaci&#243;n en pacientes hiper ni normocalci&#250;ricos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> o con ingestas altas de calcio<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a>&#46; Probablemente no se deba solamente a las diferencias de ingesta de sal&#44; sino que la complejidad de inter-relaciones con el calcio diet&#233;tico y las prote&#237;nas animales deben de ser responsables de la p&#233;rdida de correlaci&#243;n&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">En nuestro estudio la natriuria disminuye desde la dieta libre a la primera fase con Nutrison<span class="elsevierStyleSup">&#174;</span>&#44; sin aporte extra de ClNa&#46; En un estudio en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a>&#44; con una dieta de menos de 2&#44;5<span class="elsevierStyleHsp" style=""></span>g de sal&#44; la natriuria es de 25&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;04<span class="elsevierStyleHsp" style=""></span>mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h y con una ingesta de 17&#44;5<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; asciende a 340&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;6<span class="elsevierStyleHsp" style=""></span>mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; En nuestros sujetos&#44; al empezar a aportar sal con la dosis de 6&#44;25<span class="elsevierStyleHsp" style=""></span>g&#44; sigue disminuyendo la natriuria con relaci&#243;n a &#171;0&#187;&#44; ya que con 1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa se produce un notable incremento de ARP y aldosterona ante la baja ingesta de sal&#46; En &#171;5&#187; los niveles de estas hormonas permanecen elevados&#44; por lo que la excreci&#243;n de Na es similar a la obtenida en esa fase &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; Estos datos nos aportan informaci&#243;n epidemiol&#243;gica de la ingesta normal de sal que es muy superior a 6&#44;25<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a en nuestra muestra&#46; Con 11&#44;25 y 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal aumenta claramente la natriuria&#46; En comparaci&#243;n con la dieta libre&#44; en &#171;10&#187; los valores son menores y en &#171;15&#187; similares&#46; Nuestros resultados respecto a la cantidad de Na excretada en gramos nos han permitido calcular en qu&#233; cantidad de ClNa est&#225;n contenidos estos valores&#46; Hemos podido comprobar que la excreci&#243;n de Na&#44; respecto a la cantidad de sal a la que corresponde&#44; es m&#225;s baja con ingestas bajas o normales y&#44; al incrementar la ingesta&#44; aumenta&#46; As&#237;&#44; con una ingesta total de 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; se excreta el 79&#44;4&#37;&#44; mientras que con 6&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa es del 39&#44;2&#37;&#46; De manera que&#44; puesto que los resultados de la natriuria con la dieta basal no tienen diferencias estad&#237;sticas con &#171;15&#187;&#44; asumiendo que en &#171;B&#187; se ha excretado un 79&#44;4&#37;&#44; obtenemos el dato de la ingesta con la dieta libre de los sujetos estudiados&#58; 15&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;33<span class="elsevierStyleHsp" style=""></span>g de ClNa&#47;d&#237;a&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Con la calciuria se reproduce la din&#225;mica de la natriuria&#44; ya que al disminuir la excreci&#243;n de Na entre &#171;0&#187; y &#171;5&#187; en esa fase de readaptaci&#243;n&#44; no aumenta la calciuria&#44; a pesar de la mayor ingesta de ClNa&#46; Entre &#171;5&#187; y &#171;15&#187;&#44; es decir&#44; con un incremento de 10<span class="elsevierStyleHsp" style=""></span>g de ClNa &#40;desde 6&#44;25 a 16&#44;25<span class="elsevierStyleHsp" style=""></span>g&#41;&#44; aumenta la calciuria 54&#44;6<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; por lo que 1<span class="elsevierStyleHsp" style=""></span>g de sal en la dieta aumenta 5&#44;46<span class="elsevierStyleHsp" style=""></span>mg la calciuria &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; El mecanismo inductor es el aumento de la natriuria que inhibe la reabsorci&#243;n de calcio en el t&#250;bulo proximal<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a>&#46; Otra posibilidad fisiopatol&#243;gica que explique el incremento de calciuria&#44; podr&#237;a deberse al incremento de volumen extracelular por el aumento de la ingesta de sal<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a>&#46; Nuestros resultados son similares a los publicados en la mayor&#237;a de los estudios din&#225;micos con modificaci&#243;n de las cantidades ingeridas de sal &#40;1<span class="elsevierStyleHsp" style=""></span>g de ClNa en la dieta incrementa la calciuria 4&#44;19<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Las tiazidas producen la disminuci&#243;n de la calciuria por un mecanismo tubular distal independiente de la natriuria&#44; que aumenta&#44; tanto en hipercalci&#250;ricos como en normales&#46; Doce de los sujetos prosiguieron el estudio a&#241;adiendo 50<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span> el d&#237;a 9&#46;&#176; y 100<span class="elsevierStyleHsp" style=""></span>mg el 10&#46;&#176;&#46; No hemos recogido en la literatura esta metodolog&#237;a&#46; Tras la Higrotona<span class="elsevierStyleSup">&#174;</span> se incrementa la natriuria&#44; sin que hayamos registrado diferencias entre las 2 dosis y se produce un decremento de la calciuria de 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h con 100<span class="elsevierStyleHsp" style=""></span>mg&#44; no observada con 50<span class="elsevierStyleHsp" style=""></span>mg &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Partiendo de unos niveles de ingesta de sal de entre 11&#44;25 y 16&#44;25<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a &#40;asumiendo que es la cantidad usual de ClNa en la dieta libre&#41; podemos cuantificar la disminuci&#243;n de la calciuria sumando el efecto de la Higrotona<span class="elsevierStyleSup">&#174;</span> al de la restricci&#243;n de sal &#40;diferencia entre &#171;15&#187; y &#171;5&#187;&#41;&#46; Con una ingesta de sal de 6&#44;25<span class="elsevierStyleHsp" style=""></span>g &#40;respecto a 16&#44;25<span class="elsevierStyleHsp" style=""></span>g&#41; e Higrotona<span class="elsevierStyleSup">&#174;</span> 100<span class="elsevierStyleHsp" style=""></span>mg&#44; se obtiene una disminuci&#243;n de la calciuria de 105&#44;3<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h &#40;54&#44;6<span class="elsevierStyleHsp" style=""></span>mg por la disminuci&#243;n de ClNa y 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg por la Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#44; magnitud importante con relaci&#243;n al riesgo de nefrolitiasis o nefrocalcinosis&#46; Aunque hemos empleado la tiazida con una dosis de 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal&#44; creemos que su efecto&#44; con ingestas menores&#44; se mantenga&#44; al tratarse de un mecanismo independiente de la natriuria&#46; El incremento de la natriuria por las tiazidas se acompa&#241;a de una disminuci&#243;n de la natremia&#44; sin observar modificaciones de la calcemia&#46; Adem&#225;s&#44; produce un descenso evidente de potasio por aumento de su excreci&#243;n urinaria&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">El sistema renina-angiotensina-aldosterona se estimula con ingestas bajas de sodio&#44; y se frena con altas<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">20&#44;21&#8211;23</span></a>&#46; La restricci&#243;n de ClNa produce incremento de ARP y aldosterona&#44; alcanz&#225;ndose los niveles m&#225;s altos en &#171;0&#187; y &#171;5&#187;&#44; con una progresiva disminuci&#243;n posteriormente&#46; En &#171;5&#187;&#44; a pesar de ingerir 6&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#44; los niveles de ARP y aldosterona son superiores al basal&#44; lo que explica que en esa muestra la natriuria no haya aumentado todav&#237;a&#46; El nivel de la aldosterona &#171;15&#187; es inferior a &#171;B&#187;&#44; dato que vuelve a confirmar que la ingesta basal de los sujetos estudiados es inferior a 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#46; Tras el tratamiento con Higrotona<span class="elsevierStyleSup">&#174;</span> se produce un gran incremento de ARP y de aldosterona&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Concluimos que&#44; seg&#250;n nuestro estudio&#44; la ingesta de sal en la poblaci&#243;n estudiada es superior a la recomendada por la OMS y se puede cifrar en 14&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;9<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#46; Con un incremento de ingesta de 6&#44;25 a 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal&#44; la calciuria se incrementa en 54&#44;6<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h y tras la tiazida disminuye 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Los datos obtenidos podr&#237;an ser de utilidad en el manejo diet&#233;tico y terap&#233;utico de los pacientes con HC excretora o hipoparatiroidismo&#46; La elecci&#243;n de restricci&#243;n de sal en la dieta o utilizaci&#243;n de tiazidas vendr&#225; condicionada por factores como la severidad de la HC&#44; el grado de adherencia al tratamiento diet&#233;tico y farmacol&#243;gico&#44; la disponibilidad econ&#243;mica&#44; la presencia de efectos secundarios como hipotensi&#243;n o hipopotasemia y la elecci&#243;n del paciente&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Probablemente ser&#237;a recomendable iniciar en primer lugar medidas de reducci&#243;n de aporte de sal en la dieta en todos los pacientes hipercalci&#250;ricos y&#44; dado su diferente mecanismo de acci&#243;n&#44; en caso de no cumplirse los objetivos terap&#233;uticos establecidos&#44; asociar posteriormente una tiazida a la dosis indicada&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La restricci&#243;n de ClNa en la dieta y el tratamiento con tiazidas han sido utilizados en pacientes hipercalci&#250;ricos&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Conocer la ingesta habitual de sal y la correlaci&#243;n entre natriuria y calciuria con la dieta habitual &#40;B&#41; y tras la modificaci&#243;n de la cantidad de ClNa y la administraci&#243;n de tiazidas&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diecinueve j&#243;venes sanos&#44; a los que se les sustituy&#243; su dieta por 2<span class="elsevierStyleHsp" style=""></span>l diarios de Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium &#40;500<span class="elsevierStyleHsp" style=""></span>mg de Na&#41; durante 2 d&#237;as&#46; Posteriormente se a&#241;adieron cada 2 d&#237;as 5<span class="elsevierStyleHsp" style=""></span>g de ClNa &#40;&#171;5&#187;&#44; &#171;10&#187; y &#171;15&#187;&#41; y durante los 2 &#250;ltimos d&#237;as 50 y 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span> &#40;H50&#41; y &#40;H100&#41;&#46; Se determinaron iones&#44; ARP y aldosterona en sangre venosa&#44; as&#237; como la natriuria y calciuria&#46; <span class="elsevierStyleItalic">Valoraci&#243;n estad&#237;stica&#58;</span> se calcula la t de Wilcoxon y la correlaci&#243;n lineal de Pearson&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Natriuria &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 210&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#44;6 &#40;&#171;B&#187;&#41;&#59; 42&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;4 &#40;&#171;5&#187;&#41;&#59; 135&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#44;6 &#40;&#171;10&#187;&#41;&#59; 225&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#44;7 &#40;&#171;15&#187;&#41;&#46; Calciuria &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 207&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>93&#44;6 &#40;&#171;B&#187;&#41;&#59; 172&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#44;1 &#40;&#171;5&#187;&#41;&#59; 206&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#44;7 &#40;&#171;10&#187;&#41;&#59; 227&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#44;1 &#40;&#171;15&#187;&#41;&#46; Correlaci&#243;n positiva entre natriuria y calciuria en &#171;10&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;47&#41; y en &#171;15&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;67&#41;&#46; Tras Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; natriuria&#58; 232&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#44;7&#59; 377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 &#40;H50&#41;&#59; 341&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#44;4 &#40;H100&#41;&#59; Ca en orina&#58; 209&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>57&#44;4&#59; 213&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#44;6 &#40;H50&#41;&#59; 159&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#44;2 &#40;H100&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La ingesta de sal en la poblaci&#243;n estudiada es de 14&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;9<span class="elsevierStyleHsp" style=""></span>g&#47;d&#237;a&#46; Encontramos correlaci&#243;n entre natriuria y calciuria con ingestas de 11&#44;25 y 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal&#46; Con la ingesta habitual&#44; por cada gramo de sal aumenta la calciuria 5&#44;46<span class="elsevierStyleHsp" style=""></span>mg y con 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#44; la calciuria disminuye 50&#44;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Los datos podr&#237;an ser de utilidad para el manejo de pacientes con hipercalciuria excretora o hipoparatiroidismo&#46;</p></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Both dietary restriction of sodium chloride &#40;NaCl&#41; and treatment with thiazides have been used in hypercalciuric patients&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To calculate regular salt intake and investigate the correlation between natriuresis and urinary calcium with usual diet &#40;B&#41; and after changing the amount of NaCl intake and administration of thiazides&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nineteen healthy young individuals had their diet replaced by 2<span class="elsevierStyleHsp" style=""></span>l of Nutrison<span class="elsevierStyleSup">&#174;</span> Low Sodium &#40;500<span class="elsevierStyleHsp" style=""></span>mg sodium&#47;day&#41; daily for two days&#46; Then&#44; 5<span class="elsevierStyleHsp" style=""></span>g of NaCl were added every two days &#40;&#171;5&#187;&#44; &#171;10&#187; and &#171;15&#187;&#41;&#44; administering 50<span class="elsevierStyleHsp" style=""></span>mg &#40;H50&#41; and 100<span class="elsevierStyleHsp" style=""></span>mg &#40;H100&#41; of Higroton<span class="elsevierStyleSup">&#174;</span> on the last two days&#46; Blood sodium&#44; plasma renin activity &#40;PRA&#41; and aldosterone were determined in venous blood samples&#44; as were urinary sodium and calcium&#46; <span class="elsevierStyleItalic">Statistical analysis&#58;</span> Wilcoxon t-test and the Pearson linear correlation were calculated&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Urinary Na &#40;mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 210&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;6 &#40;&#171;B&#187;&#41;&#59; 42&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;4 &#40;&#171;5&#187;&#41;&#59; 135&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;6 &#40;&#171;10&#187;&#41;&#59; 225&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#46;7 &#40;&#171;15&#187;&#41;&#46; Urinary calcium &#40;mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#58; 207&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>93&#46;6 &#40;&#171;B&#187;&#41;&#59; 172&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#46;1 &#40;&#171;5&#187;&#41;&#59; 206&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#46;7 &#40;&#171;10&#187;&#41;&#59; 227&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#46;1 &#40;&#171;15&#187;&#41;&#46; A positive correlation was observed between natriuresis and urinary calcium in &#171;10&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;47&#41; and &#171;15&#187; &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;67&#41;&#46; After Higroton<span class="elsevierStyleSup">&#174;</span>&#44; natriuresis&#58; 232&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#46;7&#59; 377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 &#40;H50&#41;&#59; 341&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>68&#46;4 &#40;H100&#41;&#59; Ca in urine&#58; 209&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>57&#46;4&#59; 213&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>67&#46;6 &#40;H50&#41;&#59; 159&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#46;2 &#40;H100&#41;&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Salt intake in the population studied was estimated to be 14&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;day with a positive correlation found between sodium and calcium urine output with daily intakes of 11&#46;25 and 16&#46;25<span class="elsevierStyleHsp" style=""></span>g of salt&#46; With the usual intake&#44; for each gram of salt&#44; urinary calcium increased by 5&#46;46 mg&#47;24 h and with 100<span class="elsevierStyleHsp" style=""></span>mg of Higroton<span class="elsevierStyleSup">&#174;</span> it decreased by 50&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; These data could be useful for the management of patients with excretory hypercalciuria or hypoparathyroidism&#46;</p></span>"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlaci&#243;n entre natriuria y calciuria en &#171;0&#187;&#58; &#40;1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#41;&#59; &#171;5&#187;&#58; &#40;6&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#41;&#59; &#171;10&#187;&#58; &#40;11&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#41;&#59; &#171;15&#187;&#58; &#40;16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#41;&#59; &#171;T1&#187;&#58; &#40;16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa y 50<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#41; y &#171;T2&#187;&#58; &#40;16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa y 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#41;&#46; p&#58; nivel de significaci&#243;n&#59; r&#58; coeficiente de correlaci&#243;n&#46;</p>"
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Curva superior&#44; aldosterona plasm&#225;tica &#40;pg&#47;ml&#41;&#46; Curva inferior&#44; Na en mEq en orina&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">100 ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&#46;000<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">100<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&#46;000<span class="elsevierStyleHsp" style=""></span>ml&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Calor&#237;as&#44; kcal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Na &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Prote&#237;nas&#44; g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">K &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hidratos de carbono&#44; g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">246&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cl &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Az&#250;cares&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ca &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lactosa&#44; g&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;025&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">P &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;440&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Grasas&#44; g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mg &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">460&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Saturadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fe &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monoinsaturadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Zn &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Poliinsaturadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cu &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">180&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; A&#44; &#956;g-RE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mn &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; D</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">3</span></span><span class="elsevierStyleItalic">&#44; &#956;g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Se &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; E&#44; mg-o-TE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cr &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; K&#44; &#956;g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">I &#40;&#956;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">260&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; B</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#44; mg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Carotenoides &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; B</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#44; mg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colina &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">740&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Niacina&#44; mg NG</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">mOsm&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">A&#46; pantot&#44; mg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">H<span class="elsevierStyleInf">2</span>O &#40;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;700&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; B</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">6</span></span><span class="elsevierStyleItalic">&#44; mg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">A&#46; f&#243;lico&#44; &#956;g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">540&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; B</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">12</span></span><span class="elsevierStyleItalic">&#44; &#956;g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Biotina&#44; &#956;g</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vit&#46; C&#44; mg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Basal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;0&#187;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;5&#187;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;10&#187;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;15&#187;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Na&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>31&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>50&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">225&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">191&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>66&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">172&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>63&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">206&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>87&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">227&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">209&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>81&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">225&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>53&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">115&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">263&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>92&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">102&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">135&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">149&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Excreci&#243;n urinaria de iones con la modificaci&#243;n en la ingesta de sal</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">377<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">159&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>52&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">233&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">397&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>84&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">351&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>65&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ClNa&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">466<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>95&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">775&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mg&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">K&#44; mEq&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Excreci&#243;n urinaria de iones con 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de sal &#40;&#171;15bis&#187;&#41; y tras a&#241;adir 50 &#40;&#171;T1&#187;&#41; y 100<span class="elsevierStyleHsp" style=""></span>mg &#40;&#171;T2&#187;&#41; de Higrotona<span class="elsevierStyleSup">&#174;</span></p>"
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Basal&#58; dieta libre&#44; previa al estudio&#59; &#171;0&#187;&#58; 1&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#59; &#171;5&#187;&#58; 6&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#59; &#171;10&#187;&#58; 11&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#59; &#171;15&#187;&#58; 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#59; &#171;15bis&#187;&#58; 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa&#59; &#171;T2&#187;&#58; 16&#44;25<span class="elsevierStyleHsp" style=""></span>g de ClNa y 100<span class="elsevierStyleHsp" style=""></span>mg de Higrotona<span class="elsevierStyleSup">&#174;</span>&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;15&#187;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#171;15bis&#187;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">139&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ca&#43;&#43;&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cl&#44; mEq&#47;l&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">108&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;45&nbsp;\t\t\t\t\t\t\n
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