Letter to the Editor
Fibronectin glomerulopathy in a 88 year-old male with acute kidney injury on chronic kidney disease: A case report and a review of the literature
Glomerulopatía fibronectina en un anciano de 88 años de edad con lesión renal aguda en enfermedad renal crónica: reporte de un caso y revisión sistemática de la literatura
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Two case reports" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1485 "Ancho" => 1447 "Tamanyo" => 208937 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Arteriografía selectiva: A) Arterial humeral con un diámetro máximo de 6<span class="elsevierStyleHsp" style=""></span>cm. B) Reconstrucción tridimensional de la angiotomografía computarizada, donde se identifica una dilatación aneurismática de la arteria humeral, con un diámetro máximo de 4,5<span class="elsevierStyleHsp" style=""></span>cm y salida única por la arteria cubital.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlota Fernández Prendes, Ahmad Amer Zanabili Al-Sibbai, Mario González Gay, Jose Antonio Carreño Morrondo, Manuel Alonso Pérez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Carlota" "apellidos" => "Fernández Prendes" ] 1 => array:2 [ "nombre" => "Ahmad Amer" "apellidos" => "Zanabili Al-Sibbai" ] 2 => array:2 [ "nombre" => "Mario" "apellidos" => "González Gay" ] 3 => array:2 [ "nombre" => "Jose Antonio" "apellidos" => "Carreño Morrondo" ] 4 => array:2 [ "nombre" => "Manuel" "apellidos" => "Alonso Pérez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2013251417300275" "doi" => "10.1016/j.nefroe.2017.01.024" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251417300275?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516301448?idApp=UINPBA000064" "url" => "/02116995/0000003700000001/v3_201702240054/S0211699516301448/v3_201702240054/es/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0211699516300583" "issn" => "02116995" "doi" => "10.1016/j.nefro.2016.04.007" "estado" => "S300" "fechaPublicacion" => "2017-01-01" "aid" => "212" "copyright" => "Sociedad Española de Nefrología" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Nefrologia. 2017;37:87-92" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8125 "formatos" => array:3 [ "EPUB" => 387 "HTML" => 6705 "PDF" => 1033 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso clínico</span>" "titulo" => "Sangrado de angiomiolipoma renal en paciente con síndrome de genes contiguos (TSC2/PKD1) tras 17 años de tratamiento renal sustitutivo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "87" "paginaFinal" => "92" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Renal angiomyolipoma bleeding in a patient with TSC2/PKD1 contiguous gene syndrome after 17 years of renal replacement therapy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2150 "Ancho" => 2589 "Tamanyo" => 446378 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Deleción de genes contiguos <span class="elsevierStyleItalic">TSC2/PKD1</span>. Diagrama de resultados del análisis de deleciones/duplicaciones mediante la técnica de <span class="elsevierStyleItalic">Multiplex Ligation-dependent Probe Amplification</span> (MLPA) del paciente con SGC (panel superior) y de un individuo control (panel inferior). Las flechas rojas indican la deleción de los exones 43 al 46 del gen <span class="elsevierStyleItalic">PKD1</span> (secuencias de referencia de <span class="elsevierStyleItalic">GenBank</span>: NM_001009944.2; NP_001009944.2): c.11713-?_12909<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>?del; p.(Ser1555fs)) y los exones 37 al 42 del gen <span class="elsevierStyleItalic">TSC2</span> (NM_000548; NP_000539): c.4663-?_5421<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>?del; p.(Val3905fs)). Nomenclatura según la <span class="elsevierStyleItalic">Human Genome Variation Society</span> (<a class="elsevierStyleInterRef" id="intr0005" href="http://www.hgvs.org/mutnomen/">http://www.hgvs.org/mutnomen/</a>).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mónica Furlano, Yaima Barreiro, Teresa Martí, Carme Facundo, César Ruiz-García, Iara DaSilva, Nadia Ayasreh, Cristina Cabrera-López, José Ballarín, Elisabet Ars, Roser Torra" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Mónica" "apellidos" => "Furlano" ] 1 => array:2 [ "nombre" => "Yaima" "apellidos" => "Barreiro" ] 2 => array:2 [ "nombre" => "Teresa" "apellidos" => "Martí" ] 3 => array:2 [ "nombre" => "Carme" "apellidos" => "Facundo" ] 4 => array:2 [ "nombre" => "César" "apellidos" => "Ruiz-García" ] 5 => array:2 [ "nombre" => "Iara" "apellidos" => "DaSilva" ] 6 => array:2 [ "nombre" => "Nadia" "apellidos" => "Ayasreh" ] 7 => array:2 [ "nombre" => "Cristina" "apellidos" => "Cabrera-López" ] 8 => 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glomerulopathy in a 88 year-old male with acute kidney injury on chronic kidney disease: A case report and a review of the literature" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "93" "paginaFinal" => "96" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Genyang Cheng, Zheng Wang, Wenming Yuan, Yanna Dou, Dong Liu, Jing Xiao, Zhanzheng Zhao" "autores" => array:7 [ 0 => array:3 [ "nombre" => "Genyang" "apellidos" => "Cheng" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] 1 => array:3 [ "nombre" => "Zheng" "apellidos" => "Wang" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] 2 => array:3 [ "nombre" => "Wenming" "apellidos" => "Yuan" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Yanna" "apellidos" => "Dou" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Dong" "apellidos" => "Liu" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Jing" "apellidos" => "Xiao" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 6 => array:4 [ "nombre" => "Zhanzheng" "apellidos" => "Zhao" "email" => array:2 [ 0 => "13938525666@139.com" 1 => "zhanzhengzhao@zzu.edu.cn" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "The Nephrology Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Zhengzhou University Institute of Nephrology, Zhengzhou, China" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Glomerulopatía fibronectina en un anciano de 88 años de edad con lesión renal aguda en enfermedad renal crónica: reporte de un caso y revisión sistemática de la literatura" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1690 "Ancho" => 3333 "Tamanyo" => 606592 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Fibronectin glomerulopathy (FGP) was first recognized through direct staining in 1992 by Mazzucco et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> It was regarded as a rare autosomal dominant disease that tends to happen in various age groups and affects both sexes. The clinical features of this disease were proteinuria, typically nephrotic range, microscopic hematuria, hypertension and a slow decline in renal function.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1–11</span></a> However, some patients progress to end-stage renal disease (ESRD) and dialysis has been reported.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">5,12–14</span></a> Herein we reported a case of FGP that was diagnosed based on the classic ultrastructural features described above. This case was unique in that FGP presents in a male who was 88 years of age and has no known family history of FGP.</p><p id="par0010" class="elsevierStylePara elsevierViewall">An 88-year-old gentleman was admitted with anuria requiring dialysis for uremic encephalopathy and volume overload. He had an extensive past medical history including chronic renal failure (baseline Cr 200–240<span class="elsevierStyleHsp" style=""></span>μmol/L) one month ago, hypertension, obstructive sleep apnea, mild cognitive impairment, query previous congestive heart failure, diastolic dysfunction, COPD, macular degeneration, benign prostatic hypertrophy and an anemia that was being investigated as an outpatient. Baseline level of proteinuria was unknown. There was no family history of kidney disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Relevant initial blood work included a serum creatinine of 1148<span class="elsevierStyleHsp" style=""></span>μmol/L, urea 82.2<span class="elsevierStyleHsp" style=""></span>mmol/L and potassium 5.7<span class="elsevierStyleHsp" style=""></span>mmol/L. During his stay in hospital, a 24-h urine collection was done and only 100<span class="elsevierStyleHsp" style=""></span>mL of urine were collected with 100<span class="elsevierStyleHsp" style=""></span>mg of protein and a protein excretion of 1<span class="elsevierStyleHsp" style=""></span>g/L. The other results of blood examination are as follows: a normal ESR, C3 and C4 values, negative ANA, c-ANCA, p-ANCA, anti-GBM antibody, hepatitis B and C serology, renal ultrasound showed normal size of the kidney. The extranuclear antigen screen was negative except RNP. Immunofixation revealed a serum IgG M-protein with kappa light chain specificity. Bone marrow studies were unremarkable.</p><p id="par0020" class="elsevierStylePara elsevierViewall">A renal biopsy was performed and light microscopy showed a lobular appearance with cellular mesangial nodules that were expanded by matrix. There was also prominent arteriolar fibrointimal hyperplasia and arteriolar hyalinosis. Congo red staining was negative for amyloid. Immunostaining was 2+ for C3 in a granular pattern in the glomerular capillary walls, however staining was negative for IgA, IgG, IgM, kappa, lambda, albumin, fibrin and C1. Electron microscopy showed prominent expansion of the mesangial and subendothelial regions with numerous randomly arranged fibrils seen under high power lens, measuring 10.7–16.8<span class="elsevierStyleHsp" style=""></span>nm in diameter. Polyclonal rabbit antibody (DAKO, A0245) was used in staining of fibronectin and there was positivity in the mesangium, mesangial nodules and capillary walls (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient received regular hemodialysis and other supportive treatment including anti-hypertension, improving anemia, and preventing renal osteopathy. Unfortunately, this patient died of heart attack half a year later.</p><p id="par0030" class="elsevierStylePara elsevierViewall">To our knowledge, most cases of FGP have presented and been diagnosed in patients under 65-year-old. As this patient was diagnosed with FGP at the age of 88, we reviewed the cases reported in literatures and attempted to explain how this patient's disease course fits within our understanding of FGP.</p><p id="par0035" class="elsevierStylePara elsevierViewall">A PubMed search using the terms “fibronectin glomerulopathy” yielded 16 articles reports in English of patients with biopsy and fibronectin staining proven FGP. This allowed us to compare the disease features of 64 patients, including the patient described in this paper (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). These patients received renal biopsy at the age of 3–88, which was a wide range. The majority of patients had proteinuria for more than 5 years before being diagnosed, which supported the idea that the onset of disease occurs at younger ages. Most of the reported cases were patients in European countries, and there were several cases reported in Asia in recent years.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">FGP is understood to present with nephrotic range proteinuria and we found 23 (35.9%) of the 64 cases that reported proteinuria were nephrotic range. 21(32.8%) patients had microhematuria at the time of biopsy. Slightly more than half of the cases had hypertension. There was no association between degree of proteinuria, microhematruia and hypertension. The degrees of renal impairment at the time of biopsy were variable. Most of them had slow decline in renal function. 22 (34.3%) patients’ serum creatinine was stable, and 24 (37.5%) patients progressed to ESRD or dead. What appears different was that our patient had severe renal impairment at the time of his diagnosis.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In general, the timing of disease seems to be the distinguishing feature of our patient. Our patient had a history of chronic kidney disease on the basis of hypertension, however he came to hospital with ESRD requiring dialysis and a renal biopsy led to the discovery of FGP. With the usual disease course of FGP being slowly progressive with proteinuria of several years’ duration, it is possible that our patient had FGP and hypertensive kidney disease for many years and that a third insult may have precipitated ESRD. In his case it may have been the concomitant pneumonia.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In conclusion, FGP is an autosomal dominant disease that has an indolent disease course after a typical presentation in adulthood. Here we reported a case of FGP diagnosed in an 88-year-old gentleman at the time of his progression to ESRD. This may suggest that he had an exceptionally long indolent course if the onset of disease was during middle age, or perhaps he had an atypically late onset of disease. Further studies are needed to characterize the disease course in FGP as well as the tendency of FGP to ESRD.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Yours sincerely,</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">These authors contributed equally to this work.</p>" "identificador" => "fn0005" ] ] "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1690 "Ancho" => 3333 "Tamanyo" => 606592 ] ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">HTN: hypertension.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Bx: biopsy.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Note: If a particular piece of information was not available, the space is filled with “N/A”.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reporter \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">No. \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age at Bx \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Femal:male \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Hypertension \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Proteinuria (g/24<span class="elsevierStyleHsp" style=""></span>h) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Micro-hematuria \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Cr (μmol/l) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Time of last outcome \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Last renal outcome \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mazzucco et al. (1992)<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14, 33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2:0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 patients: nephrotic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">53,141 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 patient: 4 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 patient: Cr was stable \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Strom et al. (1995)<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14–59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7:16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 patients: YES<br>8 patient: NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 patients: positive<br>(9 patients: nephritic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 patients: positive<br>7 patients: negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">45.8–137 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1–15 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9 patients: Cr was stable<br>4 patients: dialysis<br>4 patients: transplant<br>4 patients: dead<br>1 patient: normal Cr, renal cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Assmann et al. (1995)<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">12</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">19, 46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 patient: YES<br>1 patient: NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.8,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">76, 100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gemperle et al. (1996)<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">13</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20–46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3:6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 patients: YES<br>1 patient: NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 patients: positive<br>(1 patient: nephrotic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6–21 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 patients: hemodalysis<br>2 patients: CAPD<br>3 patients: dead \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fujigaki et al. (1997)<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1:0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.82 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sato et al. (1998)<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1–2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Niimi et al. (2002)<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">>8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cr was stable \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Castelletti et al. (2008)<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12–59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1:7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 patients: YES<br>4 patient: NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 patients: positive<br>(4 patient: nephrotic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 patients: positive<br>1 patients: negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><194.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2–23 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 patients: Cr was stable<br>2 patients: dialysis<br>1 patients: transplant<br>1 patients: dead<br>1 patient: normal Cr, renal cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yong et al. (2009)<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nephrotic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">150 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Brcic et al. (2010)<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cr was stable \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nadamuni et al. (2012)<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1:0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nephrotic range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Otsuka et al. (2012)<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><0.5<span class="elsevierStyleHsp" style=""></span>g/d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.54 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ertoy et al. (2013)<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0:1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">72.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">16 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ishimoto et al. (2013)<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1:0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Nephrotic range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">101 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 mo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dialysis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yoshino et al. (2013)<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">11</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">YES \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">88.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 yr \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.54 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Chen et al. (2015)<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">19–46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4:6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 patients: YES<br>6 patient: NO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 patients: positive<br>(2 patient: nephrotic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 patients: positive<br>6 patients: negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47–312 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N/A \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1352180.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Reported cases of fibronectin glomerulopathy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0085" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glomerulonephritis with organized deposits: a mesangiopathic, not immune complex-mediated disease? 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 11 | 11 | 22 |
| 2024 Octubre | 75 | 55 | 130 |
| 2024 Septiembre | 86 | 39 | 125 |
| 2024 Agosto | 86 | 67 | 153 |
| 2024 Julio | 43 | 31 | 74 |
| 2024 Junio | 73 | 39 | 112 |
| 2024 Mayo | 64 | 32 | 96 |
| 2024 Abril | 56 | 52 | 108 |
| 2024 Marzo | 65 | 34 | 99 |
| 2024 Febrero | 33 | 41 | 74 |
| 2024 Enero | 43 | 25 | 68 |
| 2023 Diciembre | 29 | 26 | 55 |
| 2023 Noviembre | 65 | 28 | 93 |
| 2023 Octubre | 47 | 31 | 78 |
| 2023 Septiembre | 35 | 28 | 63 |
| 2023 Agosto | 35 | 27 | 62 |
| 2023 Julio | 52 | 30 | 82 |
| 2023 Junio | 40 | 27 | 67 |
| 2023 Mayo | 80 | 37 | 117 |
| 2023 Abril | 74 | 22 | 96 |
| 2023 Marzo | 66 | 27 | 93 |
| 2023 Febrero | 57 | 31 | 88 |
| 2023 Enero | 39 | 40 | 79 |
| 2022 Diciembre | 65 | 38 | 103 |
| 2022 Noviembre | 65 | 32 | 97 |
| 2022 Octubre | 61 | 62 | 123 |
| 2022 Septiembre | 47 | 32 | 79 |
| 2022 Agosto | 58 | 55 | 113 |
| 2022 Julio | 38 | 44 | 82 |
| 2022 Junio | 49 | 44 | 93 |
| 2022 Mayo | 51 | 35 | 86 |
| 2022 Abril | 55 | 55 | 110 |
| 2022 Marzo | 63 | 55 | 118 |
| 2022 Febrero | 47 | 59 | 106 |
| 2022 Enero | 45 | 48 | 93 |
| 2021 Diciembre | 54 | 52 | 106 |
| 2021 Noviembre | 33 | 45 | 78 |
| 2021 Octubre | 55 | 44 | 99 |
| 2021 Septiembre | 29 | 50 | 79 |
| 2021 Agosto | 31 | 44 | 75 |
| 2021 Julio | 37 | 38 | 75 |
| 2021 Junio | 34 | 42 | 76 |
| 2021 Mayo | 44 | 44 | 88 |
| 2021 Abril | 108 | 70 | 178 |
| 2021 Marzo | 52 | 46 | 98 |
| 2021 Febrero | 45 | 15 | 60 |
| 2021 Enero | 49 | 24 | 73 |
| 2020 Diciembre | 31 | 15 | 46 |
| 2020 Noviembre | 38 | 25 | 63 |
| 2020 Octubre | 42 | 32 | 74 |
| 2020 Septiembre | 43 | 33 | 76 |
| 2020 Agosto | 49 | 23 | 72 |
| 2020 Julio | 44 | 18 | 62 |
| 2020 Junio | 38 | 22 | 60 |
| 2020 Mayo | 66 | 18 | 84 |
| 2020 Abril | 43 | 25 | 68 |
| 2020 Marzo | 29 | 25 | 54 |
| 2020 Febrero | 44 | 21 | 65 |
| 2020 Enero | 48 | 32 | 80 |
| 2019 Diciembre | 45 | 30 | 75 |
| 2019 Noviembre | 39 | 26 | 65 |
| 2019 Octubre | 24 | 30 | 54 |
| 2019 Septiembre | 16 | 18 | 34 |
| 2019 Agosto | 27 | 23 | 50 |
| 2019 Julio | 22 | 24 | 46 |
| 2019 Junio | 31 | 37 | 68 |
| 2019 Mayo | 28 | 28 | 56 |
| 2019 Abril | 56 | 25 | 81 |
| 2019 Marzo | 38 | 24 | 62 |
| 2019 Febrero | 32 | 17 | 49 |
| 2019 Enero | 19 | 30 | 49 |
| 2018 Diciembre | 131 | 56 | 187 |
| 2018 Noviembre | 296 | 28 | 324 |
| 2018 Octubre | 241 | 21 | 262 |
| 2018 Septiembre | 91 | 15 | 106 |
| 2018 Agosto | 62 | 16 | 78 |
| 2018 Julio | 79 | 14 | 93 |
| 2018 Junio | 83 | 15 | 98 |
| 2018 Mayo | 97 | 18 | 115 |
| 2018 Abril | 159 | 14 | 173 |
| 2018 Marzo | 148 | 15 | 163 |
| 2018 Febrero | 124 | 14 | 138 |
| 2018 Enero | 165 | 6 | 171 |
| 2017 Diciembre | 155 | 13 | 168 |
| 2017 Noviembre | 144 | 13 | 157 |
| 2017 Octubre | 48 | 7 | 55 |
| 2017 Septiembre | 64 | 16 | 80 |
| 2017 Agosto | 95 | 12 | 107 |
| 2017 Julio | 87 | 13 | 100 |
| 2017 Junio | 58 | 20 | 78 |
| 2017 Mayo | 94 | 30 | 124 |
| 2017 Abril | 129 | 18 | 147 |
| 2017 Marzo | 89 | 39 | 128 |
| 2017 Febrero | 66 | 10 | 76 |
| 2017 Enero | 33 | 17 | 50 |
| 2016 Diciembre | 29 | 6 | 35 |
| 2016 Noviembre | 42 | 9 | 51 |
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