Cystatin-C and TGF-β levels in patients with diabetic nephropathy

array:23 ["pii" => "S0211699516301126" "issn" => "02116995" "doi" => "10.1016/j.nefro.2016.06.011" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "247" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2016;36:653-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5748 "formatos" => array:3 [ "EPUB" => 401 "HTML" => 4163 "PDF" => 1184 ] ] "itemSiguiente" => array:20 [ "pii" => "S0211699516300820" "issn" => "02116995" "doi" => "10.1016/j.nefro.2016.05.018" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "231" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2016;36:660-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 12111 "formatos" => array:3 [ "EPUB" => 409 "HTML" => 10521 "PDF" => 1181 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "Supervivencia del injerto renal según la categoría de Banff 2013 en biopsia por indicación" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "660" "paginaFinal" => "666" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Renal graft survival according to Banff 2013 classification in indication biopsies" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1427 "Ancho" => 2732 "Tamanyo" => 191029 ] ] "descripcion" => array:1 [ "es" => "Distribución de los diagnósticos histológicos según el tiempo postrasplante. Acs: anticuerpos; IF/TA: fibrosis intersticial/atrofia tubular; Mediado por T: rechazo mediado por linfocitos T." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Arias-Cabrales, Dolores Redondo-Pachón, María José Pérez-Sáez, Javier Gimeno, Ignacio Sánchez-Güerri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Arias-Cabrales" ] 1 => array:2 [ "nombre" => "Dolores" "apellidos" => "Redondo-Pachón" ] 2 => array:2 [ "nombre" => "María José" "apellidos" => "Pérez-Sáez" ] 3 => array:2 [ "nombre" => "Javier" "apellidos" => "Gimeno" ] 4 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Sánchez-Güerri" ] 5 => array:2 [ "nombre" => "Sheila" "apellidos" => "Bermejo" ] 6 => array:2 [ "nombre" => "Adriana" "apellidos" => "Sierra" ] 7 => array:2 [ "nombre" => "Carla" "apellidos" => "Burballa" ] 8 => array:2 [ "nombre" => "Marisa" "apellidos" => "Mir" ] 9 => array:2 [ "nombre" => "Marta" "apellidos" => "Crespo" ] 10 => array:2 [ "nombre" => "Julio" "apellidos" => "Pascual" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S201325141630147X" "doi" => "10.1016/j.nefroe.2016.05.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630147X?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300820?idApp=UINPBA000064" "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516300820/v1_201611240148/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0211699516300911" "issn" => "02116995" "doi" => "10.1016/j.nefro.2016.06.004" "estado" => "S300" "fechaPublicacion" => "2016-11-01" "aid" => "240" "copyright" => "Sociedad Española de Nefrología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Nefrologia. 2016;36:643-52" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6244 "formatos" => array:3 [ "EPUB" => 398 "HTML" => 4690 "PDF" => 1156 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "643" "paginaFinal" => "652" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos renoprotectores del propóleo sobre la toxicidad renal aguda inducida por gentamicina en ratones albinos suizos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0030" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 963 "Ancho" => 3000 "Tamanyo" => 327855 ] ] "descripcion" => array:1 [ "en" => "Malondialdehyde immunoreaction in control (a), Gm (b) and GmP (c) treated mice." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Badr Abdullah Aldahmash, Doaa Mohamed El-Nagar, Khalid Elfakki Ibrahim" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Badr Abdullah" "apellidos" => "Aldahmash" ] 1 => array:2 [ "nombre" => "Doaa Mohamed" "apellidos" => "El-Nagar" ] 2 => array:2 [ "nombre" => "Khalid Elfakki" "apellidos" => "Ibrahim" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300911?idApp=UINPBA000064" "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516300911/v1_201611240148/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Cystatin-C and TGF-β levels in patients with diabetic nephropathy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "653" "paginaFinal" => "659" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mumtaz Takir, Aslı Dogruk Unal, Osman Kostek, Nilufer Bayraktar, Nilgun Guvener Demirag" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Mumtaz" "apellidos" => "Takir" "email" => array:1 [ 0 => "mumtaztakir@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Aslı Dogruk" "apellidos" => "Unal" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Osman" "apellidos" => "Kostek" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Nilufer" "apellidos" => "Bayraktar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Nilgun Guvener" "apellidos" => "Demirag" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Division of Endocrinology and Metabolism, Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Division of Endocrinology and Metabolism, Department of Internal Medicine, Başkent University Hospital, İstanbul, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Concentración de cistatina C y TGF-β en pacientes con nefropatía diabética" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1420 "Ancho" => 1649 "Tamanyo" => 129789 ] ] "descripcion" => array:1 [ "en" => "Correlation of serum cystatin C with microalbuminuria in all four study groups." ] ] ] "textoCompleto" => "IntroductionDiabetic nephropathy (DN) is the leading cause of chronic kidney disease.<a class="elsevierStyleCrossRefs" href="#bib0165">1,2</a> Albumin excretion rate (AER) and glomerular filtration rate (GFR) are used to stage DN. However, these measurements are not sufficient in early diagnosis and monitoring the progression of DN. Therefore early markers should be devised for these purposes. Although microalbuminuria is accepted as a risk factor and marker for DN and progressive renal insufficiency,<a class="elsevierStyleCrossRef" href="#bib0175">3</a> some patients, especially type 2 diabetics, may have normoalbuminuric chronic kidney disease.<a class="elsevierStyleCrossRef" href="#bib0180">4</a>This shows that both normoalbuminuric and albuminuric pathways are at work.<a class="elsevierStyleCrossRef" href="#bib0185">5</a> While some patients with MA present with normal kidney structure, some other normoalbuminuric diabetics have well-determined nephropathic lesion.<a class="elsevierStyleCrossRefs" href="#bib0190">6,7</a>Cystatin C which is used for measurement of GFR, is produced in all nucleated cells and filtered freely from the glomerulus. It is reabsorbed totally and catabolised in the proximal tubules. Cystatin C is a suitable marker for GFR measurement owing to not being affected by age, weight, gender and protein intake.<a class="elsevierStyleCrossRefs" href="#bib0200">8–10</a>Transforming growth factor-beta (TGF-β1) is one of the growth factors which are implicated in DN pathogenesis. TGF-β1 causes mesangial extension by promoting renal cellular hypertrophy and by inducing the extracellular matrix expansion.<a class="elsevierStyleCrossRef" href="#bib0215">11</a> Urinary TGF-β1 levels are increased as proportional to the severity of the nephropathy.<a class="elsevierStyleCrossRef" href="#bib0220">12</a>We aimed to determine the value of serum Cystatin C and TGF-β1 in early detection of diabetic nephropathy in normoalbuminuric patients with type-2 diabetes mellitus.Material and methodsPatientsThis was a cross-sectional study which was conducted at the Department of Endocrinology in Baskent University School of Medicine, Istanbul, Turkey, during 2009–2011, who agreed to participate in the study. Baskent University Ethical Committee approved the study protocol (Approval no: KA09/308). Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. We tried to exclude apparent causes of nondiabetic renal disease based on data obtained with urinary system ultrasonography, urine microscopy and urine culture. Patients who have history of nondiabetic renal disease, uncontrolled hypertension, liver disease, NYHA stage 3–4 heart failure, thyroid disease, malignity and steroid usage were excluded from the study. All participants were included in the study after signing informed consent forms.Laboratory evaluationFollowing thorough medical history and detailed physical examination, blood samples were taken from all participants for measurement of fasting blood glucose, HbA1c, blood urea, creatinine and electrolytes, lipid profile, serum albumin, high sensitive C reactive protein (hsCRP). Freshly voided early morning urine samples were also collected for urinalysis. Patients also provided 24-h collected urine specimens for measurement of microalbumin.Serum glucose, creatinine, total cholesterol, HDL and LDL cholesterol, triglyceride were studied by enzymatic colorimetric; serum albumin; bromocresol green (BCG), ure; (BUN) urease, HbA1c; immune-examination (C4000, Abbott, USA), and hsCRP was studied with immunoturbidimetric methods (C8000, Abbott, USA). Microalbumin level in 24-h urine was determined with immunoturbidimetric method (C4000 system, Abbott, USA).Estimated GFR was calculated with 6 variable MDRD equation using age, race, gender, serum creatinine, blood urea nitrogen and albumin values.<a class="elsevierStyleCrossRef" href="#bib0225">13</a>The serums of patients were stored in −20°C until laboratory analysis. Serum cystathionine C, serum TGF-β1 and urine TGF-β1 levels were determined with enzyme linked immunosorbent assay (ELISA) method. BioVendor (Czech Republic) ELISA kit and eBioscience (North America) ELISA were used for Cystatin C and TGF-β1 measurements, respectively.Statistical analysisFor statistical evaluation, NCSS (Number Cruncher Statistical System) 2007 and PASS (Power Analysis and Sample Size) 2008 Statistical Software (Utah, USA) programs were used. Oneway Anova test was used in intergroup comparison of the parameters showing normal distribution and Tukey HDS test was used in the determination of the group causing the difference. Kruskal–Wallis test was used in intergroup comparison of the parameters not showing normal distribution and Mann–Whitney U test was used in the group causing the difference. In comparison of the qualitative data, Chi-square test was used. The significance was accepted as p<0.05.ResultsA total of 78 patients with type 2 DM were included in the study (mean age 57±8. Four groups were described; patients with GFR value <60ml/min/1.73m2 and MA <30mg/day as group 1; patients with GFR value <60ml/min/1.73m2 and MA between 30mg and 300mg/day as group 2; patients with GFR value >120ml/min/1.73m2 and MA <30mg/day as group 3, and patients with GFR value between 90 and 120ml/min/1.73m2 and MA <30mg/day as group 4. There were 10 men and 10 women in group 1 and 4 whereas 10 men and 11 women in group 2 and 15 men and 2 women in group 3. The laboratory parameters of the groups are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Significant difference was present among groups with regards to mean age, fasting blood glucose, HbA1c and serum creatinine level.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>No significant difference was found among groups in terms of the presence of HT which has a major role in DN pathogenesis. The evaluation of the groups in terms of micro and macrovascular complications of diabetes is depicted in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. Highest rate of coronary artery disease (CAD) was seen Groups 1 and 2. No significance difference was evident among the groups regarding prevalence of retinopathy, diabetic foot and neuropathy (p>0.05).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Results of GFR, cystatin C, serum and urine TGF-β1, MA measurements are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. Significant difference was present among the groups in terms of cystatin C, serum and urine TGF-β1 (p<0.05). Post Hoc Tukey HSD test which was performed to determine the intragroup significance, showed that cystatin C level of groups 1 and 2 was significantly higher compared with those of groups 3 and 4 (for Group 1; p=0.001, p=0.001; for Group 2; p=0.002, p=0.01). For the serum and urine TGF-β1, we found that the levels in group 2 were significantly higher than group 4 (p=0.012; p=0.012). No significant association was determined between TGF-β1 and any of the studied variables.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Cystatin C showed a significant and positive correlation with age, duration of diabetes, and serum uric acid in group 2 (for age: r=0.477, p=0.029; for duration of diabetes: r=0.437, p=0.048; for serum uric acid: r=0.465, p=0.039). As expected, serum cystatin C level was negatively associated with estimated GFR level (r=−0.892, p=0.001) only in group 2 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). In group 3, only a negative significant correlation was present between LDL and cystatin C (r=−0.72, p=0.002). In group 4, cystatin C had a positive correlation with duration of diabetes (r=0.453, p=0.045) and a negative correlation with MA (r=−0.520, p=0.019) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>When all the patients which are taken to the study are evaluated, statistically significant relation in negative direction and in % 72.6 level is detected (r=−0.726, p=0.001). Significant negative correlation is detected between GFR and creatinine (r=−0.806, p=0.001). Positive significant correlation is detected between age, hypertension and CAD and cystatin C levels (for age r=0.534, p=0.001; for hypertension r=0.347, p=0.002; for CAD r=0.382, p=0.001, respectively).When 60ml/min/1.73m2 is selected for GFR as the cut-off value, it is observed that the cystatin C levels are significantly different between the patients who have eGFR values over and below this cut-off point (GFR<60ml/min: 1548.6±613.8; GFR≥60ml/min mean: 816.8±310.8; p=0.001). ROC analysis for cystatin C, in the cases where cystatin C is C≥1064mg/L, catch-up sensitivity of GFR in <60ml/m was calculated as 80%, specificity as 86.21%; positive conjecture value as 66.67% and negative conjecture value is calculated as 92.59% (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The area under the curve in ROC analysis was found as 85.4% and standard error was calculated as 6%.<elsevierMultimedia ident="fig0015"></elsevierMultimedia>DiscussionThe albumin excretion rate (AER) which is used in staging of DN and GFR, is not sufficient for explaining the disease progress. While albumin excretion through urine is normal, GFR can decrease without any increase in AER. By considering that DN may have normoalbuminuric stage,<a class="elsevierStyleCrossRef" href="#bib0215">11</a> this situation is reported in type 1 diabetic patients who show typical specifications in favor of DN in renal biopsy.<a class="elsevierStyleCrossRef" href="#bib0215">11</a> In our study, when detecting the early stage diabetic nephropathy, cystatin C levels are detected as higher in the groups which have normoalbuminuric eGFR <60ml/m/1.73m2 and as independent from eGFR serum and urine TGF-β1 level is detected as higher in microalbuminuria group.In AER and GFR relation age is an important factor. GFR is type 2 diabetics over 70 years old, is approximately 60ml/m/1.73m2. In our study, eGFR was the lowest and the age was the oldest in normoalbuminuric group (average 62±5 years).Today, GFR is accepted as the best index reflecting kidney function.<a class="elsevierStyleCrossRef" href="#bib0225">13</a> GFR can be directly measured with the infusion of the exogenous markers such as inulin or 51Cr-EDTA. However these methods are not practical and not used in daily practice. Therefore, for the sake of practicality, American Diabetes Association (ADA) and National Kidney Foundation suggest the formula of Cockcroft-Gault (CG) and Modification of Diet in Renal Disease four-variable (MDRD) equations to estimate GFR.<a class="elsevierStyleCrossRefs" href="#bib0230">14,15</a> Particularly MDRD equation is accepted as superior than CG owing to not depend on body weight measurement.<a class="elsevierStyleCrossRef" href="#bib0225">13</a>Serum creatinine concentration is an imperfect measure of GFR. In our study, the creatinine level in the patient groups whose GFR was <60ml/m/1.73m2, has not increased yet and the patients were normoalbuminuric. Since serum creatinine level is affected by muscle mass and diet, it is not an ideal marker for GFR calculation. Novel methods are needed for early and accurate detection of DN.Cystatin C is an endogenic marker used for GFR determination because its serum level is dependent to almost whole of eGFR particularly it is seen more valuable in normal and mild decreased eGFR.<a class="elsevierStyleCrossRef" href="#bib0200">8</a>Laterza et al.<a class="elsevierStyleCrossRef" href="#bib0185">5</a> have attributed cystatin C to be an important reagent in early stage kidney damage to its stabile production, muscle mass, not being dependent to age and gender or not showing reverse tendency to kidney secretion or blood circulation.In our study, the difference in cystatin C levels showed that even in normoalbuminuria stage, the diabetic renal disease can be identified.In early diabetic kidney disease, there are contradictory results related to the role of cystatin C. As pursuant to our study, two studies show that cystatin C is not more sensitive than creatinine.<a class="elsevierStyleCrossRefs" href="#bib0240">16,17</a> Contrary to our results, in the study where cystatin C based equations and creatinine based equations like Schwartz, MDRD and CG formulas are compared and in a meta-analysis where 46 studies included, cystatin C is considered superior than creatinine in determination of decreased GFR.<a class="elsevierStyleCrossRefs" href="#bib0250">18,19</a> Although a negative weak relation is detected in cystatin C and eGFR in our study, it was not statistically significant. We think that this situation might be due to the limited number of cases in the patient group. In the study where Mussap and colleagues have examined 52 type 2 diabetic patients,<a class="elsevierStyleCrossRef" href="#bib0260">20</a> eGFR has decreased from 120ml/m/1.73m2 to 20ml/m/1.73m2 and cystatin C has increased more than the serum creatinine has. The association between Cystatin C and eGFR was detected stronger than the serum creatinine.In the study of Surendar et al. in Indians who have glucose intolerance, it was determined that cystatin C levels have increased as comparative with glucose intolerance and the highest cystatin C levels were found in the group which had microalbuminuria and retinopathy.<a class="elsevierStyleCrossRef" href="#bib0265">21</a> In our study, no difference was detected in terms of retinopathy among the groups and cystatin C levels were found highest in the normoalbuminuric group.In the previous study, ROC analysis made for identifying the diagnostic profile of serum cystatin C in predicting eGFR <60ml/dk/1.73m2 in the type 2 diabetic patients and as similar to our study, cut-off value is detected as 1.06mg/dl, the sensitivity of serum cystatin C level is 81% and the specificity is detected as.<a class="elsevierStyleCrossRef" href="#bib0270">22</a> As pursuant to our study, serum cystatin C level of the normoalbuminuric is detected as significantly higher than the patients with GFR of ≤60ml/dk/1.73m2. This makes us think that cystatin C levels of serum and urine are related with the subclinical failure and may be the kidney uptake reagents which are measurable in the period earlier than the onset of albuminuria. In the study of Yang and friends, serum cystatin C level showed correlation with MA level.<a class="elsevierStyleCrossRef" href="#bib0275">23</a>When we consider the relation between serum cystatin C and serum creatinine levels and MDRD in whole study population we determined that the predictive ability of serum creatinine for GFR was higher. This result, which is discordant with the majority of the literature, can be connected to the insufficiency of the cases in patient groups, selecting the case from the patients who have early period DN and formation of 25% of the total patient population by microalbuminuric patient group.In the microalbuminuric patient group and in the patient group with GFR <60ml/m/1.73m2 or >60ml/m/1.73m2, negative and significant association was found. This patient group was the sole patient group with MA. This group was made up from older patients than normoalbuminuric and two other patient groups with GFR >90ml/m/1.73m2. It is known that the serum cystatin C level increases with advancing age. The presence of significant difference among the patient groups in terms of age, can be seen as another factor which limits our study.In both studies, high serum cystatin C level is associated with the previous coronary heart disease.<a class="elsevierStyleCrossRefs" href="#bib0280">24,25</a> As similar to these studies, we have found positive significant correlation between CAD and serum cystatin C in the whole patient cohort.One of the cytokines which is responsible for DN initiation and progression is TGF-β. It is proven that TGF-β intervenes to all pathological changes which depend on the diabetic kidney disease.<a class="elsevierStyleCrossRef" href="#bib0290">26</a> TGF-β causes kidney cell hypertrophy and excessive extracellular matrix production in interstitial fibroblasts, glomerular and tubular cells.In experimental DM, glomerular and tubule-interstitial compartments, expresses TGF-β or TGF-β type II receptor. Although the kidney of the non-diabetic subject removes TGF-β1 from the blood, kidney of a diabetic patient releases TGF-β1 protein into the circulation. TGF-β1 level which has increased in urine is associated with adverse clinical outcomes.<a class="elsevierStyleCrossRef" href="#bib0295">27</a> In 3 patient groups which do not have MA in our study, we have found the serum and urine TGF-β1 levels were significantly higher in the groups with MA.Increased kidney TGF-β1 production in the diabetic patients was examined and renal vein TGF-β1 concentration was found positive in diabetic patients and negative in non-diabetic patients.<a class="elsevierStyleCrossRef" href="#bib0295">27</a> Urine TGF-β1 level in the diabetic patients increased fourfold than the non-diabetic patients and as contrary to our study, increased urine TGF-β1 excretion was present in all diabetic patients irrespective of MA status.There are some limitations of our study that need to be mentioned. The most important limitation of our study is the estimation of GFR measurements. All estimates of GFR based on serum creatinine will be affected from physiologic and/or pathologic limitations<a class="elsevierStyleCrossRef" href="#bib0300">28</a> and be far from ideal GFR. On the other hand, recent studies showed the CKD-EPI creatinine equation has similar GFR prediction in different patient population compared with the MDRD Study equation, even in the earlier CKD stages.<a class="elsevierStyleCrossRefs" href="#bib0305">29,30</a> In addition, the CKD-EPI creatinine-cystatin C equation is more suitable compared with standard reference for cystatin C and creatinine based equations.<a class="elsevierStyleCrossRef" href="#bib0315">31</a> However, the cost effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered. The second important limitation is the sample size of the study groups. But we wanted to be sure about patients with type 2 diabetes mellitus without known overt diabetic nephropathy. Larger new clinical trials are recommended to determine the role of serum cystatin C, serum and urine TGF-β1 level as an early biomarker of diabetic nephropathy. The third, diabetic foot ulcer with or without concomitant peripheral arterial disease is considered as two separate disease.<a class="elsevierStyleCrossRef" href="#bib0320">32</a> In our study, we did not exam the patients whether they have peripheral vascular disease.ConclusionAlthough urinary albumin excretion is suggested for detection of type 2 diabetic nephropathy, there is group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy. In addition, despite that serum and urine TGF-β1 levels were also significantly higher in patients with MA, only increased urine TGF-β1 excretion was present in all diabetic patients irrespective of MA status.Conflict of interestThe authors declare no conflict of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres761788" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec763346" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres761789" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec763347" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Laboratory evaluation" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conclusion" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-09-10" "fechaAceptado" => "2016-06-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec763346" "palabras" => array:5 [ 0 => "Diabetic nephropathy" 1 => "Cystatin C" 2 => "TGF-β1" 3 => "Microalbuminuria" 4 => "Normoalbuminuria" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec763347" "palabras" => array:5 [ 0 => "Nefropatía diabética" 1 => "Cistatina C" 2 => "TGF-β1" 3 => "Microalbuminuria" 4 => "Normoalbuminuria" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectiveTo evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-β levels. MethodsCross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine. Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study. Recruited patients were stratified into four groups, matched in terms of age, gender, microalbuminuria level and estimated GFR calculated with MDRD. Results78 patients were enrolled. They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate.Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients (p<0.01), but there were no differences in terms of other diabetic complications. Serum cystatin C level was significantly higher in normoalbuminuric group one patients, while serum and urinary TGF-β1 levels were higher in microalbuminuric group two patients. The serum level of cystatin C was found to negatively correlate with eGFR in group two patients (r=−0.892, p<0.001). Finally, there was a negative correlation between eGFR and cystatin C in all the patient groups (r=−0.726, p=0.001). ConclusionsAlthough urinary albumin excretion is recommended for the detection of type two diabetic nephropathy, there is a group of patients with decreased eGFR but without increased urinary albumin excretion, in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "ObjetivoEvaluar la insuficiencia renal en pacientes con diabetes tipo 2 con normoalbuminuria o microalbuminuria mediante la detección de la concentración de cistatina C en suero y de TGF-β en suero y orina. MétodosEstudio transversal realizado en el Departamento de Endocrinología de la Facultad de Medicina de la Universidad de Baskent. En el estudio, se incluyó a pacientes con diabetes mellitus tipo 2 sin nefropatía diabética manifiesta conocida. Los pacientes seleccionados se estratificaron en 4 grupos, agrupados en términos de edad, sexo, grado de microalbuminuria y filtración glomerular estimada (FGe) calculada mediante la fórmula MDRD. ResultadosSe incluyó a 78 pacientes. Se clasificaron en 4 grupos dependiendo de la excreción urinaria de albúmina y de la FGe.Se observó que la complicación macrovascular era mayor en los pacientes con microalbuminuria que en otros (p<0,01), pero no hubo diferencias con relación a otras complicaciones diabéticas. La concentración sérica de cistatina C fue significativamente mayor en los pacientes del grupo 1 con normoalbuminuria, mientras que las concentraciones de TGF-β1 en suero y orina fueron mayores en los pacientes del grupo 2 con microalbuminuria. Se observó una correlación negativa entre la concentración sérica de cistatina C y la FGe en los pacientes del grupo 2 (r=−0,892, p<0,001). Por último, se observó una correlación negativa entre la FGe y la cistatina C en todos los grupos de pacientes (r=−0,726, p=0,001). ConclusionesAunque se recomienda la excreción urinaria de albúmina para la detección de la nefropatía diabética tipo 2, hay un grupo de pacientes con disminución de la FGe, pero sin aumento de la excreción urinaria de albúmina, en los que estaba indicado usar la concentración de cistatina C en suero como un biomarcador temprano de nefropatía diabética." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1336 "Ancho" => 1603 "Tamanyo" => 134343 ] ] "descripcion" => array:1 [ "en" => "Correlation of serum cystatin C with eGFR in all four study groups." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1420 "Ancho" => 1649 "Tamanyo" => 129789 ] ] "descripcion" => array:1 [ "en" => "Correlation of serum cystatin C with microalbuminuria in all four study groups." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1523 "Ancho" => 1504 "Tamanyo" => 60542 ] ] "descripcion" => array:1 [ "en" => "ROC curve which is obtained for cystatin C." ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Body mass index (BMI), hemoglobin A1c (HbA1c), high density lipoprotein (HDL), low density lipoprotein (LDL), high sensitive c reactive protein (hsCRP).Mean (standard deviation)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 (n=21) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 (n=17) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62.9 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59.7 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49.0 (8.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53.7 (8.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of Diabetes Mellitus, months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">116.4 (100.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">127.4 (96.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">96.0 (71.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">78.0 (45.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.243 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI, kg/m2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.6 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.0 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.2 (6.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31.6 (5.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.430 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucose, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">118.8 (26.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">152.1 (62.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">143.9 (42.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">121.1 (32.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.043 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HbA1c, % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.9 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.3 (1.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.7 (1.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.9 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Albumin, g/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.2 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.2 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.3 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.3 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.559 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL-Cholesterol, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">41.2 (10.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38.4 (7.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.8 (10.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.5 (5.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.774 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL-Cholesterol, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">102.6 (35.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">115.3 (34.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">129.6 (30.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">105.9 (29.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.079 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglyceride, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">148.3 (91.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">174.8 (79.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">175.9 (50.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">184.6 (68.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sedimentation rate, mm/hour \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.3 (14.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.1 (10.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.4 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.2 (8.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.412 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hsCRP, mg/dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.1 (4.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.0 (7.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.5 (5.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.6 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.969 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1258386.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Laboratory parameters of the study groups." ] ] 4 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 (n=21) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 (n=17) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Coronary Artery Disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (45%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (47.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (5.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2(10%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Retinopathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (33.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (11.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (20%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.454 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetic Foot \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (%0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (4.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (%0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (%0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.432 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuropathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (45%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (42.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (11.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.096 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1258388.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Evaluation of micro and macro vascular complications according to groups." ] ] 5 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Estimated glomerular filtration rate (eGFR), serum transforming growth factor-beta 1 (sTGF-β1), urine transforming growth factor-beta 1 (uTGF-β1), microalbuminuria (MA).Mean (standard deviation)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 (n=21) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 (n=17) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 (n=20) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">eGFR, mL/m/1.73m2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54.7 (7.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">78.2 (23.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">125.7 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">106.1 (29.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cystatin C, mg/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.4 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.7 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">sTGF-β1, ng/mL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.7 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.9 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.1 (6.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.2 (6.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">uTGF-β1, pg/mgcre \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">558.6 (23.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">633.2 (100.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">539.3 (204.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">442.2 (214.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MA, mg/24h \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.0 (5.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">89.8 (37.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.2 (8.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.3 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1258387.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Estimated GFR, cystatin C, serum and urine TGF-β1, and MA levels in study groups." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0165" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diabetic nephropathy: prevention and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.H. Parving" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2001.00020.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2001" "volumen" => "60" "paginaInicial" => "2041" "paginaFinal" => "2055" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11703631" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0170" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.C. Viberti" 1 => "R.D. Hill" 2 => "R.J. Jarrett" 3 => "A. Argyropoulos" 4 => "U. Mahmud" 5 => "H. Keen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1982" "volumen" => "1" "paginaInicial" => "1430" "paginaFinal" => "1432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2884516" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0175" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kidney complications: factors that protect the diabetic vasculature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Rask-Madsen" 1 => "G.L. King" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nm0110-40" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "2010" "volumen" => "16" "paginaInicial" => "40" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20057426" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0180" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diabetic nephropathy: diagnosis, prevention, and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. Gross" 1 => "M.J. de Azevedo" 2 => "S.P. Silveiro" 3 => "L.H. Canani" 4 => "M.L. Caramori" 5 => "T. Zelmanovitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "2005" "volumen" => "28" "paginaInicial" => "164" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15616252" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0185" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C: an improved estimator of glomerular filtration rate?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "O.F. Laterza" 1 => "C.P. Price" 2 => "M.G. Scott" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "2002" "volumen" => "48" "paginaInicial" => "699" "paginaFinal" => "707" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11978596" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0190" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microalbuminuria is not rare before 5 years of IDDM. EURODIAB IDDM Complications Study Group and the WHO Multinational Study of Vascular Disease in Diabetes Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Stephenson" 1 => "J.H. Fuller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Diabetes Complicat" "fecha" => "1994" "volumen" => "8" "paginaInicial" => "166" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8086653" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0195" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microalbuminuriauria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.J. Schultz" 1 => "T. Konopelska-Bahu" 2 => "R.N. Dalton" 3 => "T.A. Carroll" 4 => "I. Stratton" 5 => "E.A. Gale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes Care" "fecha" => "1999" "volumen" => "22" "paginaInicial" => "495" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10097935" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0200" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.P. Harmoinen" 1 => "T.T. Kouri" 2 => "O.R. Wirta" 3 => "T.J. Lehtimäki" 4 => "V. Rantalaiho" 5 => "V.M. Turjanmaa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Nephrol" "fecha" => "1999" "volumen" => "52" "paginaInicial" => "363" "paginaFinal" => "370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10604644" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0205" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C as a renal function estimator in advanced chronic renal failure stages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.V. Martin" 1 => "S. Barroso" 2 => "O. Herraez" 3 => "F. De Sande" 4 => "F. Caravaca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nefrologia" "fecha" => "2006" "volumen" => "26" "paginaInicial" => "433" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17058854" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0210" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.J. López" 1 => "E.B. Sacristán" 2 => "M. Micó" 3 => "M.F. Arias" 4 => "M.F. de Sande" 5 => "S. Alejo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3265/Nefrologia.pre2011.Jul.10834" "Revista" => array:6 [ "tituloSerie" => "Nefrologia" "fecha" => "2010" "volumen" => "31" "paginaInicial" => "560" "paginaFinal" => "566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21959722" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0215" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Albuminuric and non-albuminuric pathways to renal impairment in diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. Macisaac" 1 => "G. Jerums" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Minerva Endocrinol" "fecha" => "2005" "volumen" => "30" "paginaInicial" => "161" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16208306" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0220" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progressive decline in renal function in diabetic patients with and without albuminuria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Tsalamandris" 1 => "T.J. Allen" 2 => "R.E. Gilbert" 3 => "A. Sinha" 4 => "S. Panagiotopoulos" 5 => "M.E. Cooper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1994" "volumen" => "43" "paginaInicial" => "649" "paginaFinal" => "655" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8168641" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0225" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.S. Levey" 1 => "J.P. Bosch" 2 => "J.B. Lewis" 3 => "T. Greene" 4 => "N. Rogers" 5 => "D. Roth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1999" "volumen" => "130" "paginaInicial" => "461" "paginaFinal" => "470" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10075613" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0230" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "American Diabetes Association Clinical Practice Recommendations 2001" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Diabetes Care" "fecha" => "2001" "volumen" => "24" "numero" => "Suppl. 1" "paginaInicial" => "S1" "paginaFinal" => "S133" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11403001" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673607601111" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0235" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cockcroft–Gault formula is biased by body weight in diabetic patients with renal impairment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Rigalleau" 1 => "C. Lasseur" 2 => "C. Perlemoine" 3 => "N. Barthe" 4 => "C. Raffaitin" 5 => "P. Chauveau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.metabol.2005.07.014" "Revista" => array:7 [ "tituloSerie" => "Metabolism" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "108" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16324928" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022395613001751" "estado" => "S300" "issn" => "00223956" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0240" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interest of cystatin C in screening diabetic patients for early impairment of renal function" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Perlemoine" 1 => "M.C. Beauvieux" 2 => "V. Rigalleau" 3 => "L. Baillet" 4 => "N. Barthes" 5 => "P. Derache" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "2003" "volumen" => "52" "paginaInicial" => "1258" "paginaFinal" => "1264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14564676" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0245" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C is not more sensitive than creatinine for detecting early renal impairment in patients with diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Oddoze" 1 => "S. Morange" 2 => "H. Portugal" 3 => "Y. Berland" 4 => "B. Dussol" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/ajkd.2001.26096" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2001" "volumen" => "38" "paginaInicial" => "310" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11479157" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0250" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How to estimate GFR-serum creatinine, serum cystatin C or equations?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Herget-Rosenthal" 1 => "A. Bokenkamp" 2 => "W. Hofmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinbiochem.2006.10.014" "Revista" => array:6 [ "tituloSerie" => "Clin Biochem" "fecha" => "2007" "volumen" => "40" "paginaInicial" => "153" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17234172" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0255" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.R. Dharnidharka" 1 => "C. Kwon" 2 => "G. Stevens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/ajkd.2002.34487" "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2002" "volumen" => "40" "paginaInicial" => "221" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12148093" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0260" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Mussap" 1 => "M. Dalla Vestra" 2 => "P. Fioretto" 3 => "A. Saller" 4 => "M. Varagnolo" 5 => "R. Nosadini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2002.00253.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2002" "volumen" => "61" "paginaInicial" => "1453" "paginaFinal" => "1461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11918752" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0265" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance (CURES-32)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Surendar" 1 => "S. Anuradha" 2 => "B. Ashley" 3 => "M. Balasubramanyam" 4 => "V. Aravindhan" 5 => "M. Rema" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/met.2008.0084" "Revista" => array:6 [ "tituloSerie" => "Metab Syndr Relat Disord" "fecha" => "2009" "volumen" => "7" "paginaInicial" => "419" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19419268" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0270" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y.K. Jeon" 1 => "M.R. Kim" 2 => "J.E. Huh" 3 => "S.Y. Kang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3346/jkms.2011.26.2.258" "Revista" => array:6 [ "tituloSerie" => "J Korean Med Sci" "fecha" => "2011" "volumen" => "26" "paginaInicial" => "258" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21286018" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0275" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of serum cystatin C to detect early decline of glomerular filtration rate in type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y.S. Yang" 1 => "C.H. Peng" 2 => "C.K. Lin" 3 => "C.P. Wang" 4 => "C.N. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "801" "paginaFinal" => "806" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17575370" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0280" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystatin C and mortality risk in the elderly: the health, aging, and body composition study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.G. Shlipak" 1 => "C.L. Wassel Fyr" 2 => "G.M. Chertow" 3 => "T.B. Harris" 4 => "S.B. Kritchevsky" 5 => "F.A. Tylavsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "254" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8785395" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0285" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical correlates and heritability of cystatin C (from the Framingham Offspring Study)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.I. Parikh" 1 => "S.J. Hwang" 2 => "Q. Yang" 3 => "M.G. Larson" 4 => "C.Y. Guo" 5 => "S.J. Robins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2008.06.039" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2008" "volumen" => "102" "paginaInicial" => "1194" "paginaFinal" => "1198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18940290" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0290" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Chen" 1 => "B. Jim" 2 => "F.N. Ziyadeh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Nephrol" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "532" "paginaFinal" => "543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14631561" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0295" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased renal production of transforming growth factor-beta1 in patients with type II diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Sharma" 1 => "F.N. Ziyadeh" 2 => "B. Alzahabi" 3 => "T.A. McGowan" 4 => "S. Kapoor" 5 => "B.R. Kurnik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Diabetes" "fecha" => "1997" "volumen" => "46" "paginaInicial" => "854" "paginaFinal" => "859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9133555" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0300" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.D. Rule" 1 => "K.R. Bailey" 2 => "G.L. Schwartz" 3 => "S. Khosla" 4 => "J.C. Lieske" 5 => "L.J. Melton 3rd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.2008.698" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2009" "volumen" => "75" "paginaInicial" => "1071" "paginaFinal" => "1078" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19177154" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0305" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modification of Diet in Renal Disease versus Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in obese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Bouquegneau" 1 => "E. Vidal-Petiot" 2 => "F. Vrtonsnik" 3 => "E. Cavalier" 4 => "M. Rorive" 5 => "J.M. Krzesinski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gft329" "Revista" => array:7 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2013" "volumen" => "28" "numero" => "Suppl. 4" "paginaInicial" => "iv122" "paginaFinal" => "iv130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24026245" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0310" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Masson" 1 => "M. Flamant" 2 => "N. Maillard" 3 => "A.D. Rule" 4 => "F. Vrtovsnik" 5 => "M.N. Peraldi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TP.0b013e318288caa6" "Revista" => array:6 [ "tituloSerie" => "Transplantation" "fecha" => "2013" "volumen" => "95" "paginaInicial" => "1211" "paginaFinal" => "1217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23511243" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0315" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is the Chronic Kidney Disease epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X. Liu" 1 => "H. Ma" 2 => "H. Huang" 3 => "C. Wang" 4 => "H. Tang" 5 => "M. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/CIA.S52774" "Revista" => array:5 [ "tituloSerie" => "Clin Interv Aging" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "1387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24143084" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0320" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Prompers" 1 => "N. Schaper" 2 => "J. Apelqvist" 3 => "M. Edmonds" 4 => "E. Jude" 5 => "D. Mauricio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00125-008-0940-0" "Revista" => array:6 [ "tituloSerie" => "Diabetologia" "fecha" => "2008" "volumen" => "51" "paginaInicial" => "747" "paginaFinal" => "755" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18297261" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516301126/v1_201611240148/en/main.assets" "Apartado" => array:4 [ "identificador" => "42448" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003600000006/v1_201611240148/S0211699516301126/v1_201611240148/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516301126?idApp=UINPBA000064"]

Estadísticas

Original article

Cystatin-C and TGF-β levels in patients with diabetic nephropathy

Concentración de cistatina C y TGF-β en pacientes con nefropatía diabética

Mumtaz Takira,

Autor para correspondencia

mumtaztakir@yahoo.com

Corresponding author.

, Aslı Dogruk Unalb, Osman Kostekc, Nilufer Bayraktarb, Nilgun Guvener Demiragb

a Division of Endocrinology and Metabolism, Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey

b Division of Endocrinology and Metabolism, Department of Internal Medicine, Başkent University Hospital, İstanbul, Turkey

c Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey

Leído

11821

Veces
se ha leído el artículo

3434

Total PDF

8387

Total HTML

Compartir estadísticas

 array:23 [
  "pii" => "S0211699516301126"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2016.06.011"
  "estado" => "S300"
  "fechaPublicacion" => "2016-11-01"
  "aid" => "247"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2016;36:653-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5748
    "formatos" => array:3 [
      "EPUB" => 401
      "HTML" => 4163
      "PDF" => 1184
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0211699516300820"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2016.05.018"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "231"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2016;36:660-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 12111
      "formatos" => array:3 [
        "EPUB" => 409
        "HTML" => 10521
        "PDF" => 1181
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Supervivencia del injerto renal seg&#250;n la categor&#237;a de Banff&#160;2013 en biopsia por indicaci&#243;n"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "660"
          "paginaFinal" => "666"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Renal graft survival according to Banff&#160;2013 classification in indication biopsies"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1427
              "Ancho" => 2732
              "Tamanyo" => 191029
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n de los diagn&#243;sticos histol&#243;gicos seg&#250;n el tiempo postrasplante&#46;</p> <p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Acs&#58; anticuerpos&#59; IF&#47;TA&#58; fibrosis intersticial&#47;atrofia tubular&#59; Mediado por T&#58; rechazo mediado por linfocitos T&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carlos Arias-Cabrales, Dolores Redondo-Pach&#243;n, Mar&#237;a Jos&#233; P&#233;rez-S&#225;ez, Javier Gimeno, Ignacio S&#225;nchez-G&#252;erri, Sheila Bermejo, Adriana Sierra, Carla Burballa, Marisa Mir, Marta Crespo, Julio Pascual"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Arias-Cabrales"
            ]
            1 => array:2 [
              "nombre" => "Dolores"
              "apellidos" => "Redondo-Pach&#243;n"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a Jos&#233;"
              "apellidos" => "P&#233;rez-S&#225;ez"
            ]
            3 => array:2 [
              "nombre" => "Javier"
              "apellidos" => "Gimeno"
            ]
            4 => array:2 [
              "nombre" => "Ignacio"
              "apellidos" => "S&#225;nchez-G&#252;erri"
            ]
            5 => array:2 [
              "nombre" => "Sheila"
              "apellidos" => "Bermejo"
            ]
            6 => array:2 [
              "nombre" => "Adriana"
              "apellidos" => "Sierra"
            ]
            7 => array:2 [
              "nombre" => "Carla"
              "apellidos" => "Burballa"
            ]
            8 => array:2 [
              "nombre" => "Marisa"
              "apellidos" => "Mir"
            ]
            9 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Crespo"
            ]
            10 => array:2 [
              "nombre" => "Julio"
              "apellidos" => "Pascual"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S201325141630147X"
        "doi" => "10.1016/j.nefroe.2016.05.012"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S201325141630147X?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300820?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516300820/v1_201611240148/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0211699516300911"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2016.06.004"
    "estado" => "S300"
    "fechaPublicacion" => "2016-11-01"
    "aid" => "240"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "ssu"
    "cita" => "Nefrologia. 2016;36:643-52"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 6244
      "formatos" => array:3 [
        "EPUB" => 398
        "HTML" => 4690
        "PDF" => 1156
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "643"
          "paginaFinal" => "652"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Efectos renoprotectores del prop&#243;leo sobre la toxicidad renal aguda inducida por gentamicina en ratones albinos suizos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0030"
          "etiqueta" => "Fig&#46; 6"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr6.jpeg"
              "Alto" => 963
              "Ancho" => 3000
              "Tamanyo" => 327855
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Malondialdehyde immunoreaction in control &#40;a&#41;&#44; Gm &#40;b&#41; and GmP &#40;c&#41; treated mice&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Badr Abdullah Aldahmash, Doaa Mohamed El-Nagar, Khalid Elfakki Ibrahim"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Badr Abdullah"
              "apellidos" => "Aldahmash"
            ]
            1 => array:2 [
              "nombre" => "Doaa Mohamed"
              "apellidos" => "El-Nagar"
            ]
            2 => array:2 [
              "nombre" => "Khalid Elfakki"
              "apellidos" => "Ibrahim"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516300911?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516300911/v1_201611240148/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Cystatin-C and TGF-&#946; levels in patients with diabetic nephropathy"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "653"
        "paginaFinal" => "659"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mumtaz Takir, Asl&#305; Dogruk Unal, Osman Kostek, Nilufer Bayraktar, Nilgun Guvener Demirag"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Mumtaz"
            "apellidos" => "Takir"
            "email" => array:1 [
              0 => "mumtaztakir&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Asl&#305; Dogruk"
            "apellidos" => "Unal"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Osman"
            "apellidos" => "Kostek"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Nilufer"
            "apellidos" => "Bayraktar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Nilgun Guvener"
            "apellidos" => "Demirag"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Division of Endocrinology and Metabolism&#44; Department of Internal Medicine&#44; Goztepe Training and Research Hospital&#44; Istanbul Medeniyet University&#44; Istanbul&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Division of Endocrinology and Metabolism&#44; Department of Internal Medicine&#44; Ba&#351;kent University Hospital&#44; &#304;stanbul&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Department of Internal Medicine&#44; Goztepe Training and Research Hospital&#44; Istanbul Medeniyet University&#44; Istanbul&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Concentraci&#243;n de cistatina C y TGF-&#946; en pacientes con nefropat&#237;a diab&#233;tica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1420
            "Ancho" => 1649
            "Tamanyo" => 129789
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Correlation of serum cystatin C with microalbuminuria in all four study groups&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Diabetic nephropathy &#40;DN&#41; is the leading cause of chronic kidney disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">1&#44;2</span></a> Albumin excretion rate &#40;AER&#41; and glomerular filtration rate &#40;GFR&#41; are used to stage DN&#46; However&#44; these measurements are not sufficient in early diagnosis and monitoring the progression of DN&#46; Therefore early markers should be devised for these purposes&#46; Although microalbuminuria is accepted as a risk factor and marker for DN and progressive renal insufficiency&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">3</span></a> some patients&#44; especially type 2 diabetics&#44; may have normoalbuminuric chronic kidney disease&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This shows that both normoalbuminuric and albuminuric pathways are at work&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> While some patients with MA present with normal kidney structure&#44; some other normoalbuminuric diabetics have well-determined nephropathic lesion&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Cystatin C which is used for measurement of GFR&#44; is produced in all nucleated cells and filtered freely from the glomerulus&#46; It is reabsorbed totally and catabolised in the proximal tubules&#46; Cystatin C is a suitable marker for GFR measurement owing to not being affected by age&#44; weight&#44; gender and protein intake&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Transforming growth factor-beta &#40;TGF-&#946;1&#41; is one of the growth factors which are implicated in DN pathogenesis&#46; TGF-&#946;1 causes mesangial extension by promoting renal cellular hypertrophy and by inducing the extracellular matrix expansion&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">11</span></a> Urinary TGF-&#946;1 levels are increased as proportional to the severity of the nephropathy&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">We aimed to determine the value of serum Cystatin C and TGF-&#946;1 in early detection of diabetic nephropathy in normoalbuminuric patients with type-2 diabetes mellitus&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">This was a cross-sectional study which was conducted at the Department of Endocrinology in Baskent University School of Medicine&#44; Istanbul&#44; Turkey&#44; during 2009&#8211;2011&#44; who agreed to participate in the study&#46; Baskent University Ethical Committee approved the study protocol &#40;Approval no&#58; KA09&#47;308&#41;&#46; Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study&#46; Recruited patients were stratified into four groups&#44; matched in terms of age&#44; gender&#44; microalbuminuria level and estimated GFR calculated with MDRD&#46; We tried to exclude apparent causes of nondiabetic renal disease based on data obtained with urinary system ultrasonography&#44; urine microscopy and urine culture&#46; Patients who have history of nondiabetic renal disease&#44; uncontrolled hypertension&#44; liver disease&#44; NYHA stage 3&#8211;4 heart failure&#44; thyroid disease&#44; malignity and steroid usage were excluded from the study&#46; All participants were included in the study after signing informed consent forms&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Laboratory evaluation</span><p id="par0035" class="elsevierStylePara elsevierViewall">Following thorough medical history and detailed physical examination&#44; blood samples were taken from all participants for measurement of fasting blood glucose&#44; HbA1c&#44; blood urea&#44; creatinine and electrolytes&#44; lipid profile&#44; serum albumin&#44; high sensitive C reactive protein &#40;hsCRP&#41;&#46; Freshly voided early morning urine samples were also collected for urinalysis&#46; Patients also provided 24-h collected urine specimens for measurement of microalbumin&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Serum glucose&#44; creatinine&#44; total cholesterol&#44; HDL and LDL cholesterol&#44; triglyceride were studied by enzymatic colorimetric&#59; serum albumin&#59; bromocresol green &#40;BCG&#41;&#44; ure&#59; &#40;BUN&#41; urease&#44; HbA1c&#59; immune-examination &#40;C4000&#44; Abbott&#44; USA&#41;&#44; and hsCRP was studied with immunoturbidimetric methods &#40;C8000&#44; Abbott&#44; USA&#41;&#46; Microalbumin level in 24-h urine was determined with immunoturbidimetric method &#40;C4000 system&#44; Abbott&#44; USA&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Estimated GFR was calculated with 6 variable MDRD equation using age&#44; race&#44; gender&#44; serum creatinine&#44; blood urea nitrogen and albumin values&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The serums of patients were stored in &#8722;20<span class="elsevierStyleHsp" style=""></span>&#176;C until laboratory analysis&#46; Serum cystathionine C&#44; serum TGF-&#946;1 and urine TGF-&#946;1 levels were determined with enzyme linked immunosorbent assay &#40;ELISA&#41; method&#46; BioVendor &#40;Czech Republic&#41; ELISA kit and eBioscience &#40;North America&#41; ELISA were used for Cystatin C and TGF-&#946;1 measurements&#44; respectively&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">For statistical evaluation&#44; NCSS &#40;Number Cruncher Statistical System&#41; 2007 and PASS &#40;Power Analysis and Sample Size&#41; 2008 Statistical Software &#40;Utah&#44; USA&#41; programs were used&#46; Oneway Anova test was used in intergroup comparison of the parameters showing normal distribution and Tukey HDS test was used in the determination of the group causing the difference&#46; Kruskal&#8211;Wallis test was used in intergroup comparison of the parameters not showing normal distribution and Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test was used in the group causing the difference&#46; In comparison of the qualitative data&#44; Chi-square test was used&#46; The significance was accepted as <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">A total of 78 patients with type 2 DM were included in the study &#40;mean age 57<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46; Four groups were described&#59; patients with GFR value &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and MA &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;day as group 1&#59; patients with GFR value &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and MA between 30<span class="elsevierStyleHsp" style=""></span>mg and 300<span class="elsevierStyleHsp" style=""></span>mg&#47;day as group 2&#59; patients with GFR value &#62;120<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and MA &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;day as group 3&#44; and patients with GFR value between 90 and 120<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and MA &#60;30<span class="elsevierStyleHsp" style=""></span>mg&#47;day as group 4&#46; There were 10 men and 10 women in group 1 and 4 whereas 10 men and 11 women in group 2 and 15 men and 2 women in group 3&#46; The laboratory parameters of the groups are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Significant difference was present among groups with regards to mean age&#44; fasting blood glucose&#44; HbA1c and serum creatinine level&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">No significant difference was found among groups in terms of the presence of HT which has a major role in DN pathogenesis&#46; The evaluation of the groups in terms of micro and macrovascular complications of diabetes is depicted in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; Highest rate of coronary artery disease &#40;CAD&#41; was seen Groups 1 and 2&#46; No significance difference was evident among the groups regarding prevalence of retinopathy&#44; diabetic foot and neuropathy &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Results of GFR&#44; cystatin C&#44; serum and urine TGF-&#946;1&#44; MA measurements are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; Significant difference was present among the groups in terms of cystatin C&#44; serum and urine TGF-&#946;1 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Post Hoc Tukey HSD test which was performed to determine the intragroup significance&#44; showed that cystatin C level of groups 1 and 2 was significantly higher compared with those of groups 3 and 4 &#40;for Group 1&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#59; for Group 2&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; For the serum and urine TGF-&#946;1&#44; we found that the levels in group 2 were significantly higher than group 4 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#41;&#46; No significant association was determined between TGF-&#946;1 and any of the studied variables&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Cystatin C showed a significant and positive correlation with age&#44; duration of diabetes&#44; and serum uric acid in group 2 &#40;for age&#58; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;477&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;029&#59; for duration of diabetes&#58; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;437&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;048&#59; for serum uric acid&#58; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;465&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;039&#41;&#46; As expected&#44; serum cystatin C level was negatively associated with estimated GFR level &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;892&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; only in group 2 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In group 3&#44; only a negative significant correlation was present between LDL and cystatin C &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;72&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46; In group 4&#44; cystatin C had a positive correlation with duration of diabetes &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;453&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;045&#41; and a negative correlation with MA &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;520&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;019&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">When all the patients which are taken to the study are evaluated&#44; statistically significant relation in negative direction and in &#37; 72&#46;6 level is detected &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;726&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Significant negative correlation is detected between GFR and creatinine &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;806&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Positive significant correlation is detected between age&#44; hypertension and CAD and cystatin C levels &#40;for age <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;534&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#59; for hypertension <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;347&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#59; for CAD <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;382&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; respectively&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">When 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> is selected for GFR as the cut-off value&#44; it is observed that the cystatin C levels are significantly different between the patients who have eGFR values over and below this cut-off point &#40;GFR<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#58; 1548&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>613&#46;8&#59; GFR<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>ml&#47;min mean&#58; 816&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>310&#46;8&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; ROC analysis for cystatin C&#44; in the cases where cystatin C is C<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>1064<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#44; catch-up sensitivity of GFR in &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;m was calculated as 80&#37;&#44; specificity as 86&#46;21&#37;&#59; positive conjecture value as 66&#46;67&#37; and negative conjecture value is calculated as 92&#46;59&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The area under the curve in ROC analysis was found as 85&#46;4&#37; and standard error was calculated as 6&#37;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The albumin excretion rate &#40;AER&#41; which is used in staging of DN and GFR&#44; is not sufficient for explaining the disease progress&#46; While albumin excretion through urine is normal&#44; GFR can decrease without any increase in AER&#46; By considering that DN may have normoalbuminuric stage&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">11</span></a> this situation is reported in type 1 diabetic patients who show typical specifications in favor of DN in renal biopsy&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">11</span></a> In our study&#44; when detecting the early stage diabetic nephropathy&#44; cystatin C levels are detected as higher in the groups which have normoalbuminuric eGFR &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and as independent from eGFR serum and urine TGF-&#946;1 level is detected as higher in microalbuminuria group&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In AER and GFR relation age is an important factor&#46; GFR is type 2 diabetics over 70 years old&#44; is approximately 60<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; In our study&#44; eGFR was the lowest and the age was the oldest in normoalbuminuric group &#40;average 62<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5 years&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Today&#44; GFR is accepted as the best index reflecting kidney function&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a> GFR can be directly measured with the infusion of the exogenous markers such as inulin or <span class="elsevierStyleSup">51</span>Cr-EDTA&#46; However these methods are not practical and not used in daily practice&#46; Therefore&#44; for the sake of practicality&#44; American Diabetes Association &#40;ADA&#41; and National Kidney Foundation suggest the formula of Cockcroft-Gault &#40;CG&#41; and Modification of Diet in Renal Disease four-variable &#40;MDRD&#41; equations to estimate GFR&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">14&#44;15</span></a> Particularly MDRD equation is accepted as superior than CG owing to not depend on body weight measurement&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Serum creatinine concentration is an imperfect measure of GFR&#46; In our study&#44; the creatinine level in the patient groups whose GFR was &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; has not increased yet and the patients were normoalbuminuric&#46; Since serum creatinine level is affected by muscle mass and diet&#44; it is not an ideal marker for GFR calculation&#46; Novel methods are needed for early and accurate detection of DN&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cystatin C is an endogenic marker used for GFR determination because its serum level is dependent to almost whole of eGFR particularly it is seen more valuable in normal and mild decreased eGFR&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">8</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Laterza et al&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> have attributed cystatin C to be an important reagent in early stage kidney damage to its stabile production&#44; muscle mass&#44; not being dependent to age and gender or not showing reverse tendency to kidney secretion or blood circulation&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In our study&#44; the difference in cystatin C levels showed that even in normoalbuminuria stage&#44; the diabetic renal disease can be identified&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In early diabetic kidney disease&#44; there are contradictory results related to the role of cystatin C&#46; As pursuant to our study&#44; two studies show that cystatin C is not more sensitive than creatinine&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">16&#44;17</span></a> Contrary to our results&#44; in the study where cystatin C based equations and creatinine based equations like Schwartz&#44; MDRD and CG formulas are compared and in a meta-analysis where 46 studies included&#44; cystatin C is considered superior than creatinine in determination of decreased GFR&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">18&#44;19</span></a> Although a negative weak relation is detected in cystatin C and eGFR in our study&#44; it was not statistically significant&#46; We think that this situation might be due to the limited number of cases in the patient group&#46; In the study where Mussap and colleagues have examined 52 type 2 diabetic patients&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">20</span></a> eGFR has decreased from 120<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> to 20<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> and cystatin C has increased more than the serum creatinine has&#46; The association between Cystatin C and eGFR was detected stronger than the serum creatinine&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In the study of Surendar et al&#46; in Indians who have glucose intolerance&#44; it was determined that cystatin C levels have increased as comparative with glucose intolerance and the highest cystatin C levels were found in the group which had microalbuminuria and retinopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">21</span></a> In our study&#44; no difference was detected in terms of retinopathy among the groups and cystatin C levels were found highest in the normoalbuminuric group&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In the previous study&#44; ROC analysis made for identifying the diagnostic profile of serum cystatin C in predicting eGFR &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;dk&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> in the type 2 diabetic patients and as similar to our study&#44; cut-off value is detected as 1&#46;06<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; the sensitivity of serum cystatin C level is 81&#37; and the specificity is detected as&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">22</span></a> As pursuant to our study&#44; serum cystatin C level of the normoalbuminuric is detected as significantly higher than the patients with GFR of &#8804;60<span class="elsevierStyleHsp" style=""></span>ml&#47;dk&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; This makes us think that cystatin C levels of serum and urine are related with the subclinical failure and may be the kidney uptake reagents which are measurable in the period earlier than the onset of albuminuria&#46; In the study of Yang and friends&#44; serum cystatin C level showed correlation with MA level&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">23</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">When we consider the relation between serum cystatin C and serum creatinine levels and MDRD in whole study population we determined that the predictive ability of serum creatinine for GFR was higher&#46; This result&#44; which is discordant with the majority of the literature&#44; can be connected to the insufficiency of the cases in patient groups&#44; selecting the case from the patients who have early period DN and formation of 25&#37; of the total patient population by microalbuminuric patient group&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In the microalbuminuric patient group and in the patient group with GFR &#60;60<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> or &#62;60<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#44; negative and significant association was found&#46; This patient group was the sole patient group with MA&#46; This group was made up from older patients than normoalbuminuric and two other patient groups with GFR &#62;90<span class="elsevierStyleHsp" style=""></span>ml&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&#46; It is known that the serum cystatin C level increases with advancing age&#46; The presence of significant difference among the patient groups in terms of age&#44; can be seen as another factor which limits our study&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In both studies&#44; high serum cystatin C level is associated with the previous coronary heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">24&#44;25</span></a> As similar to these studies&#44; we have found positive significant correlation between CAD and serum cystatin C in the whole patient cohort&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">One of the cytokines which is responsible for DN initiation and progression is TGF-&#946;&#46; It is proven that TGF-&#946; intervenes to all pathological changes which depend on the diabetic kidney disease&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> TGF-&#946; causes kidney cell hypertrophy and excessive extracellular matrix production in interstitial fibroblasts&#44; glomerular and tubular cells&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">In experimental DM&#44; glomerular and tubule-interstitial compartments&#44; expresses TGF-&#946; or TGF-&#946; type II receptor&#46; Although the kidney of the non-diabetic subject removes TGF-&#946;1 from the blood&#44; kidney of a diabetic patient releases TGF-&#946;1 protein into the circulation&#46; TGF-&#946;1 level which has increased in urine is associated with adverse clinical outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">27</span></a> In 3 patient groups which do not have MA in our study&#44; we have found the serum and urine TGF-&#946;1 levels were significantly higher in the groups with MA&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Increased kidney TGF-&#946;1 production in the diabetic patients was examined and renal vein TGF-&#946;1 concentration was found positive in diabetic patients and negative in non-diabetic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">27</span></a> Urine TGF-&#946;1 level in the diabetic patients increased fourfold than the non-diabetic patients and as contrary to our study&#44; increased urine TGF-&#946;1 excretion was present in all diabetic patients irrespective of MA status&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">There are some limitations of our study that need to be mentioned&#46; The most important limitation of our study is the estimation of GFR measurements&#46; All estimates of GFR based on serum creatinine will be affected from physiologic and&#47;or pathologic limitations<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">28</span></a> and be far from ideal GFR&#46; On the other hand&#44; recent studies showed the CKD-EPI creatinine equation has similar GFR prediction in different patient population compared with the MDRD Study equation&#44; even in the earlier CKD stages&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">29&#44;30</span></a> In addition&#44; the CKD-EPI creatinine-cystatin C equation is more suitable compared with standard reference for cystatin C and creatinine based equations&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">31</span></a> However&#44; the cost effectiveness of the CKD-EPI creatinine-cystatin C equation for clinical use should be considered&#46; The second important limitation is the sample size of the study groups&#46; But we wanted to be sure about patients with type 2 diabetes mellitus without known overt diabetic nephropathy&#46; Larger new clinical trials are recommended to determine the role of serum cystatin C&#44; serum and urine TGF-&#946;1 level as an early biomarker of diabetic nephropathy&#46; The third&#44; diabetic foot ulcer with or without concomitant peripheral arterial disease is considered as two separate disease&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">32</span></a> In our study&#44; we did not exam the patients whether they have peripheral vascular disease&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conclusion</span><p id="par0175" class="elsevierStylePara elsevierViewall">Although urinary albumin excretion is suggested for detection of type 2 diabetic nephropathy&#44; there is group of patients with decreased eGFR but without increased urinary albumin excretion&#44; in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy&#46; In addition&#44; despite that serum and urine TGF-&#946;1 levels were also significantly higher in patients with MA&#44; only increased urine TGF-&#946;1 excretion was present in all diabetic patients irrespective of MA status&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflict of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres761788"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec763346"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres761789"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec763347"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material and methods"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Laboratory evaluation"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conclusion"
        ]
        9 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Conflict of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-09-10"
    "fechaAceptado" => "2016-06-25"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec763346"
          "palabras" => array:5 [
            0 => "Diabetic nephropathy"
            1 => "Cystatin C"
            2 => "TGF-&#946;1"
            3 => "Microalbuminuria"
            4 => "Normoalbuminuria"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec763347"
          "palabras" => array:5 [
            0 => "Nefropat&#237;a diab&#233;tica"
            1 => "Cistatina C"
            2 => "TGF-&#946;1"
            3 => "Microalbuminuria"
            4 => "Normoalbuminuria"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate renal impairment in type 2 diabetic patients with normoalbuminuria or microalbuminuria by detection of serum cystatin C and serum and urinary TGF-&#946; levels&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study conducted at the Department of Endocrinology in Baskent University School of Medicine&#46; Patients with type 2 diabetes mellitus without known overt diabetic nephropathy were included in the study&#46; Recruited patients were stratified into four groups&#44; matched in terms of age&#44; gender&#44; microalbuminuria level and estimated GFR calculated with MDRD&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">78 patients were enrolled&#46; They were categorized into four groups depending on their urinary albumin excretion and estimated glomerular filtration rate&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Macrovascular complication was found to be higher in patients with microalbuminuria than in other patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; but there were no differences in terms of other diabetic complications&#46; Serum cystatin C level was significantly higher in normoalbuminuric group one patients&#44; while serum and urinary TGF-&#946;1 levels were higher in microalbuminuric group two patients&#46; The serum level of cystatin C was found to negatively correlate with eGFR in group two patients &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;892&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Finally&#44; there was a negative correlation between eGFR and cystatin C in all the patient groups &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;726&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Although urinary albumin excretion is recommended for the detection of type two diabetic nephropathy&#44; there is a group of patients with decreased eGFR but without increased urinary albumin excretion&#44; in which serum cystatin C level was indicated to be used as an early biomarker of diabetic nephropathy&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Evaluar la insuficiencia renal en pacientes con diabetes tipo 2 con normoalbuminuria o microalbuminuria mediante la detecci&#243;n de la concentraci&#243;n de cistatina C en suero y de TGF-&#946; en suero y orina&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio transversal realizado en el Departamento de Endocrinolog&#237;a de la Facultad de Medicina de la Universidad de Baskent&#46; En el estudio&#44; se incluy&#243; a pacientes con diabetes mellitus tipo 2 sin nefropat&#237;a diab&#233;tica manifiesta conocida&#46; Los pacientes seleccionados se estratificaron en 4 grupos&#44; agrupados en t&#233;rminos de edad&#44; sexo&#44; grado de microalbuminuria y filtraci&#243;n glomerular estimada &#40;FGe&#41; calculada mediante la f&#243;rmula MDRD&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 78 pacientes&#46; Se clasificaron en 4 grupos dependiendo de la excreci&#243;n urinaria de alb&#250;mina y de la FGe&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se observ&#243; que la complicaci&#243;n macrovascular era mayor en los pacientes con microalbuminuria que en otros &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#44; pero no hubo diferencias con relaci&#243;n a otras complicaciones diab&#233;ticas&#46; La concentraci&#243;n s&#233;rica de cistatina C fue significativamente mayor en los pacientes del grupo 1 con normoalbuminuria&#44; mientras que las concentraciones de TGF-&#946;1 en suero y orina fueron mayores en los pacientes del grupo 2 con microalbuminuria&#46; Se observ&#243; una correlaci&#243;n negativa entre la concentraci&#243;n s&#233;rica de cistatina C y la FGe en los pacientes del grupo 2 &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#44;892&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Por &#250;ltimo&#44; se observ&#243; una correlaci&#243;n negativa entre la FGe y la cistatina C en todos los grupos de pacientes &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#44;726&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Aunque se recomienda la excreci&#243;n urinaria de alb&#250;mina para la detecci&#243;n de la nefropat&#237;a diab&#233;tica tipo 2&#44; hay un grupo de pacientes con disminuci&#243;n de la FGe&#44; pero sin aumento de la excreci&#243;n urinaria de alb&#250;mina&#44; en los que estaba indicado usar la concentraci&#243;n de cistatina C en suero como un biomarcador temprano de nefropat&#237;a diab&#233;tica&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1336
            "Ancho" => 1603
            "Tamanyo" => 134343
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation of serum cystatin C with eGFR in all four study groups&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1420
            "Ancho" => 1649
            "Tamanyo" => 129789
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Correlation of serum cystatin C with microalbuminuria in all four study groups&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1523
            "Ancho" => 1504
            "Tamanyo" => 60542
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ROC curve which is obtained for cystatin C&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Body mass index &#40;BMI&#41;&#44; hemoglobin A1c &#40;HbA1c&#41;&#44; high density lipoprotein &#40;HDL&#41;&#44; low density lipoprotein &#40;LDL&#41;&#44; high sensitive c reactive protein &#40;hsCRP&#41;&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Mean &#40;standard deviation&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;9 &#40;5&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;7 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;0 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;7 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of Diabetes Mellitus&#44; months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116&#46;4 &#40;100&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127&#46;4 &#40;96&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">96&#46;0 &#40;71&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#46;0 &#40;45&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;243&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI&#44; kg&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;6 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;0 &#40;5&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;2 &#40;6&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;6 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;430&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glucose&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">118&#46;8 &#40;26&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152&#46;1 &#40;62&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">143&#46;9 &#40;42&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">121&#46;1 &#40;32&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;043</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HbA1c&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;1 &#40;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;9 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;3 &#40;1&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;7 &#40;1&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;028</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2 &#40;0&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;9 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;6 &#40;0&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;6 &#40;0&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Albumin&#44; g&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2 &#40;0&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;3 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;3 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;559&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL-Cholesterol&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;2 &#40;10&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;8 &#40;10&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;5 &#40;5&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;774&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL-Cholesterol&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">102&#46;6 &#40;35&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">115&#46;3 &#40;34&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">129&#46;6 &#40;30&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">105&#46;9 &#40;29&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;079&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglyceride&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">148&#46;3 &#40;91&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">174&#46;8 &#40;79&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">175&#46;9 &#40;50&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">184&#46;6 &#40;68&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;074&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sedimentation rate&#44; mm&#47;hour&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;3 &#40;14&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;1 &#40;10&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;4 &#40;5&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;2 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">hsCRP&#44; mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;1 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;0 &#40;7&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;5 &#40;5&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;6 &#40;5&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;969&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1258386.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Laboratory parameters of the study groups&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Coronary Artery Disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;47&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;5&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Retinopathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;11&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;454&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetic Foot&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;&#37;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;4&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;&#37;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;&#37;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;432&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuropathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;42&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;11&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1258388.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Evaluation of micro and macro vascular complications according to groups&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Estimated glomerular filtration rate &#40;eGFR&#41;&#44; serum transforming growth factor-beta 1 &#40;sTGF-&#946;1&#41;&#44; urine transforming growth factor-beta 1 &#40;uTGF-&#946;1&#41;&#44; microalbuminuria &#40;MA&#41;&#46;</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Mean &#40;standard deviation&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 3 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Group 4 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">eGFR&#44; mL&#47;m&#47;1&#46;73<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;7 &#40;7&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#46;2 &#40;23&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">125&#46;7 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">106&#46;1 &#40;29&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cystatin C&#44; mg&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;4 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;6 &#40;0&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;7 &#40;0&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">sTGF-&#946;1&#44; ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;7 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;9 &#40;3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;1 &#40;6&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;2 &#40;6&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;022</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">uTGF-&#946;1&#44; pg&#47;mg<span class="elsevierStyleHsp" style=""></span>cre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">558&#46;6 &#40;23&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">633&#46;2 &#40;100&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">539&#46;3 &#40;204&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">442&#46;2 &#40;214&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;022</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MA&#44; mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;0 &#40;5&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89&#46;8 &#40;37&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#46;2 &#40;8&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;3 &#40;5&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1258387.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Estimated GFR&#44; cystatin C&#44; serum and urine TGF-&#946;1&#44; and MA levels in study groups&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetic nephropathy&#58; prevention and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;H&#46; Parving"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.2001.00020.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2001"
                        "volumen" => "60"
                        "paginaInicial" => "2041"
                        "paginaFinal" => "2055"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11703631"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;C&#46; Viberti"
                            1 => "R&#46;D&#46; Hill"
                            2 => "R&#46;J&#46; Jarrett"
                            3 => "A&#46; Argyropoulos"
                            4 => "U&#46; Mahmud"
                            5 => "H&#46; Keen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1982"
                        "volumen" => "1"
                        "paginaInicial" => "1430"
                        "paginaFinal" => "1432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2884516"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Kidney complications&#58; factors that protect the diabetic vasculature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Rask-Madsen"
                            1 => "G&#46;L&#46; King"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nm0110-40"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Med"
                        "fecha" => "2010"
                        "volumen" => "16"
                        "paginaInicial" => "40"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20057426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetic nephropathy&#58; diagnosis&#44; prevention&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Gross"
                            1 => "M&#46;J&#46; de Azevedo"
                            2 => "S&#46;P&#46; Silveiro"
                            3 => "L&#46;H&#46; Canani"
                            4 => "M&#46;L&#46; Caramori"
                            5 => "T&#46; Zelmanovitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2005"
                        "volumen" => "28"
                        "paginaInicial" => "164"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15616252"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C&#58; an improved estimator of glomerular filtration rate&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "O&#46;F&#46; Laterza"
                            1 => "C&#46;P&#46; Price"
                            2 => "M&#46;G&#46; Scott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2002"
                        "volumen" => "48"
                        "paginaInicial" => "699"
                        "paginaFinal" => "707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11978596"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microalbuminuria is not rare before 5 years of IDDM&#46; EURODIAB IDDM Complications Study Group and the WHO Multinational Study of Vascular Disease in Diabetes Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Stephenson"
                            1 => "J&#46;H&#46; Fuller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Diabetes Complicat"
                        "fecha" => "1994"
                        "volumen" => "8"
                        "paginaInicial" => "166"
                        "paginaFinal" => "173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8086653"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microalbuminuriauria prevalence varies with age&#44; sex&#44; and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study&#46; Oxford Regional Prospective Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;J&#46; Schultz"
                            1 => "T&#46; Konopelska-Bahu"
                            2 => "R&#46;N&#46; Dalton"
                            3 => "T&#46;A&#46; Carroll"
                            4 => "I&#46; Stratton"
                            5 => "E&#46;A&#46; Gale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "1999"
                        "volumen" => "22"
                        "paginaInicial" => "495"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10097935"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of plasma cystatin C as a marker for glomerular filtration rate in patients with type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;P&#46; Harmoinen"
                            1 => "T&#46;T&#46; Kouri"
                            2 => "O&#46;R&#46; Wirta"
                            3 => "T&#46;J&#46; Lehtim&#228;ki"
                            4 => "V&#46; Rantalaiho"
                            5 => "V&#46;M&#46; Turjanmaa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Nephrol"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "363"
                        "paginaFinal" => "370"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10604644"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C as a renal function estimator in advanced chronic renal failure stages"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;V&#46; Martin"
                            1 => "S&#46; Barroso"
                            2 => "O&#46; Herraez"
                            3 => "F&#46; De Sande"
                            4 => "F&#46; Caravaca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2006"
                        "volumen" => "26"
                        "paginaInicial" => "433"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17058854"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;J&#46; L&#243;pez"
                            1 => "E&#46;B&#46; Sacrist&#225;n"
                            2 => "M&#46; Mic&#243;"
                            3 => "M&#46;F&#46; Arias"
                            4 => "M&#46;F&#46; de Sande"
                            5 => "S&#46; Alejo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3265/Nefrologia.pre2011.Jul.10834"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nefrologia"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "560"
                        "paginaFinal" => "566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21959722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Albuminuric and non-albuminuric pathways to renal impairment in diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;J&#46; Macisaac"
                            1 => "G&#46; Jerums"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Endocrinol"
                        "fecha" => "2005"
                        "volumen" => "30"
                        "paginaInicial" => "161"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16208306"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive decline in renal function in diabetic patients with and without albuminuria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Tsalamandris"
                            1 => "T&#46;J&#46; Allen"
                            2 => "R&#46;E&#46; Gilbert"
                            3 => "A&#46; Sinha"
                            4 => "S&#46; Panagiotopoulos"
                            5 => "M&#46;E&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "1994"
                        "volumen" => "43"
                        "paginaInicial" => "649"
                        "paginaFinal" => "655"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8168641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A more accurate method to estimate glomerular filtration rate from serum creatinine&#58; a new prediction equation&#46; Modification of Diet in Renal Disease Study Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Levey"
                            1 => "J&#46;P&#46; Bosch"
                            2 => "J&#46;B&#46; Lewis"
                            3 => "T&#46; Greene"
                            4 => "N&#46; Rogers"
                            5 => "D&#46; Roth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1999"
                        "volumen" => "130"
                        "paginaInicial" => "461"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10075613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "American Diabetes Association Clinical Practice Recommendations 2001"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:8 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2001"
                        "volumen" => "24"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "S133"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11403001"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673607601111"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cockcroft&#8211;Gault formula is biased by body weight in diabetic patients with renal impairment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Rigalleau"
                            1 => "C&#46; Lasseur"
                            2 => "C&#46; Perlemoine"
                            3 => "N&#46; Barthe"
                            4 => "C&#46; Raffaitin"
                            5 => "P&#46; Chauveau"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.metabol.2005.07.014"
                      "Revista" => array:7 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "108"
                        "paginaFinal" => "112"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16324928"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022395613001751"
                          "estado" => "S300"
                          "issn" => "00223956"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interest of cystatin C in screening diabetic patients for early impairment of renal function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Perlemoine"
                            1 => "M&#46;C&#46; Beauvieux"
                            2 => "V&#46; Rigalleau"
                            3 => "L&#46; Baillet"
                            4 => "N&#46; Barthes"
                            5 => "P&#46; Derache"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Metabolism"
                        "fecha" => "2003"
                        "volumen" => "52"
                        "paginaInicial" => "1258"
                        "paginaFinal" => "1264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14564676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C is not more sensitive than creatinine for detecting early renal impairment in patients with diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Oddoze"
                            1 => "S&#46; Morange"
                            2 => "H&#46; Portugal"
                            3 => "Y&#46; Berland"
                            4 => "B&#46; Dussol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.2001.26096"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2001"
                        "volumen" => "38"
                        "paginaInicial" => "310"
                        "paginaFinal" => "316"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11479157"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "How to estimate GFR-serum creatinine&#44; serum cystatin C or equations&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Herget-Rosenthal"
                            1 => "A&#46; Bokenkamp"
                            2 => "W&#46; Hofmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinbiochem.2006.10.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Biochem"
                        "fecha" => "2007"
                        "volumen" => "40"
                        "paginaInicial" => "153"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17234172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum cystatin C is superior to serum creatinine as a marker of kidney function&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46;R&#46; Dharnidharka"
                            1 => "C&#46; Kwon"
                            2 => "G&#46; Stevens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.2002.34487"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2002"
                        "volumen" => "40"
                        "paginaInicial" => "221"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12148093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Mussap"
                            1 => "M&#46; Dalla Vestra"
                            2 => "P&#46; Fioretto"
                            3 => "A&#46; Saller"
                            4 => "M&#46; Varagnolo"
                            5 => "R&#46; Nosadini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.2002.00253.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2002"
                        "volumen" => "61"
                        "paginaInicial" => "1453"
                        "paginaFinal" => "1461"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11918752"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C and cystatin glomerular filtration rate as markers of early renal disease in Asian Indian subjects with glucose intolerance &#40;CURES-32&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Surendar"
                            1 => "S&#46; Anuradha"
                            2 => "B&#46; Ashley"
                            3 => "M&#46; Balasubramanyam"
                            4 => "V&#46; Aravindhan"
                            5 => "M&#46; Rema"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/met.2008.0084"
                      "Revista" => array:6 [
                        "tituloSerie" => "Metab Syndr Relat Disord"
                        "fecha" => "2009"
                        "volumen" => "7"
                        "paginaInicial" => "419"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19419268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Y&#46;K&#46; Jeon"
                            1 => "M&#46;R&#46; Kim"
                            2 => "J&#46;E&#46; Huh"
                            3 => "S&#46;Y&#46; Kang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3346/jkms.2011.26.2.258"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Korean Med Sci"
                        "fecha" => "2011"
                        "volumen" => "26"
                        "paginaInicial" => "258"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21286018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of serum cystatin C to detect early decline of glomerular filtration rate in type 2 diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;S&#46; Yang"
                            1 => "C&#46;H&#46; Peng"
                            2 => "C&#46;K&#46; Lin"
                            3 => "C&#46;P&#46; Wang"
                            4 => "C&#46;N&#46; Huang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2007"
                        "volumen" => "46"
                        "paginaInicial" => "801"
                        "paginaFinal" => "806"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17575370"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystatin C and mortality risk in the elderly&#58; the health&#44; aging&#44; and body composition study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;G&#46; Shlipak"
                            1 => "C&#46;L&#46; Wassel Fyr"
                            2 => "G&#46;M&#46; Chertow"
                            3 => "T&#46;B&#46; Harris"
                            4 => "S&#46;B&#46; Kritchevsky"
                            5 => "F&#46;A&#46; Tylavsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2006"
                        "volumen" => "7"
                        "paginaInicial" => "254"
                        "paginaFinal" => "261"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8785395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical correlates and heritability of cystatin C &#40;from the Framingham Offspring Study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;I&#46; Parikh"
                            1 => "S&#46;J&#46; Hwang"
                            2 => "Q&#46; Yang"
                            3 => "M&#46;G&#46; Larson"
                            4 => "C&#46;Y&#46; Guo"
                            5 => "S&#46;J&#46; Robins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2008.06.039"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "1194"
                        "paginaFinal" => "1198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18940290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetic nephropathy and transforming growth factor-beta&#58; transforming our view of glomerulosclerosis and fibrosis build-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Chen"
                            1 => "B&#46; Jim"
                            2 => "F&#46;N&#46; Ziyadeh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Nephrol"
                        "fecha" => "2003"
                        "volumen" => "23"
                        "paginaInicial" => "532"
                        "paginaFinal" => "543"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14631561"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased renal production of transforming growth factor-beta1 in patients with type II diabetes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Sharma"
                            1 => "F&#46;N&#46; Ziyadeh"
                            2 => "B&#46; Alzahabi"
                            3 => "T&#46;A&#46; McGowan"
                            4 => "S&#46; Kapoor"
                            5 => "B&#46;R&#46; Kurnik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "1997"
                        "volumen" => "46"
                        "paginaInicial" => "854"
                        "paginaFinal" => "859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9133555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;D&#46; Rule"
                            1 => "K&#46;R&#46; Bailey"
                            2 => "G&#46;L&#46; Schwartz"
                            3 => "S&#46; Khosla"
                            4 => "J&#46;C&#46; Lieske"
                            5 => "L&#46;J&#46; Melton 3rd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ki.2008.698"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2009"
                        "volumen" => "75"
                        "paginaInicial" => "1071"
                        "paginaFinal" => "1078"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19177154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modification of Diet in Renal Disease versus Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in obese patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Bouquegneau"
                            1 => "E&#46; Vidal-Petiot"
                            2 => "F&#46; Vrtonsnik"
                            3 => "E&#46; Cavalier"
                            4 => "M&#46; Rorive"
                            5 => "J&#46;M&#46; Krzesinski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft329"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "numero" => "Suppl&#46; 4"
                        "paginaInicial" => "iv122"
                        "paginaFinal" => "iv130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24026245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Masson"
                            1 => "M&#46; Flamant"
                            2 => "N&#46; Maillard"
                            3 => "A&#46;D&#46; Rule"
                            4 => "F&#46; Vrtovsnik"
                            5 => "M&#46;N&#46; Peraldi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/TP.0b013e318288caa6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Transplantation"
                        "fecha" => "2013"
                        "volumen" => "95"
                        "paginaInicial" => "1211"
                        "paginaFinal" => "1217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23511243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is the Chronic Kidney Disease epidemiology Collaboration creatinine&#8211;cystatin C equation useful for glomerular filtration rate estimation in the elderly&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Liu"
                            1 => "H&#46; Ma"
                            2 => "H&#46; Huang"
                            3 => "C&#46; Wang"
                            4 => "H&#46; Tang"
                            5 => "M&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/CIA.S52774"
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Interv Aging"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "1387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24143084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of outcome in individuals with diabetic foot ulcers&#58; focus on the differences between individuals with and without peripheral arterial disease&#46; The EURODIALE Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Prompers"
                            1 => "N&#46; Schaper"
                            2 => "J&#46; Apelqvist"
                            3 => "M&#46; Edmonds"
                            4 => "E&#46; Jude"
                            5 => "D&#46; Mauricio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00125-008-0940-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetologia"
                        "fecha" => "2008"
                        "volumen" => "51"
                        "paginaInicial" => "747"
                        "paginaFinal" => "755"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18297261"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000003600000006/v1_201611240148/S0211699516301126/v1_201611240148/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003600000006/v1_201611240148/S0211699516301126/v1_201611240148/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699516301126?idApp=UINPBA000064"
]

Información del artículo

ISSN: 02116995
Idioma original: Inglés

DOI:10.1016/j.nefro.2016.06.011

Datos actualizados diariamente

año/Mes	Html	Pdf	Total

2024 Noviembre	10	12	22
2024 Octubre	77	39	116
2024 Septiembre	75	30	105
2024 Agosto	113	59	172
2024 Julio	79	30	109
2024 Junio	94	49	143
2024 Mayo	91	40	131
2024 Abril	110	56	166
2024 Marzo	69	38	107
2024 Febrero	56	36	92
2024 Enero	52	23	75
2023 Diciembre	56	24	80
2023 Noviembre	71	41	112
2023 Octubre	60	30	90
2023 Septiembre	61	33	94
2023 Agosto	67	15	82
2023 Julio	65	27	92
2023 Junio	57	23	80
2023 Mayo	76	36	112
2023 Abril	48	20	68
2023 Marzo	96	33	129
2023 Febrero	91	23	114
2023 Enero	54	32	86
2022 Diciembre	92	41	133
2022 Noviembre	87	43	130
2022 Octubre	72	46	118
2022 Septiembre	90	40	130
2022 Agosto	68	60	128
2022 Julio	62	55	117
2022 Junio	72	53	125
2022 Mayo	67	36	103
2022 Abril	141	57	198
2022 Marzo	91	55	146
2022 Febrero	50	60	110
2022 Enero	63	47	110
2021 Diciembre	70	48	118
2021 Noviembre	99	55	154
2021 Octubre	69	60	129
2021 Septiembre	52	57	109
2021 Agosto	56	65	121
2021 Julio	66	44	110
2021 Junio	77	49	126
2021 Mayo	69	47	116
2021 Abril	104	89	193
2021 Marzo	75	35	110
2021 Febrero	66	28	94
2021 Enero	54	25	79
2020 Diciembre	49	31	80
2020 Noviembre	72	27	99
2020 Octubre	60	23	83
2020 Septiembre	76	45	121
2020 Agosto	75	21	96
2020 Julio	76	23	99
2020 Junio	81	30	111
2020 Mayo	92	27	119
2020 Abril	79	39	118
2020 Marzo	83	30	113
2020 Febrero	96	33	129
2020 Enero	112	40	152
2019 Diciembre	134	44	178
2019 Noviembre	83	45	128
2019 Octubre	94	43	137
2019 Septiembre	32	26	58
2019 Agosto	48	41	89
2019 Julio	66	62	128
2019 Junio	58	36	94
2019 Mayo	48	40	88
2019 Abril	76	47	123
2019 Marzo	75	40	115
2019 Febrero	52	28	80
2019 Enero	51	42	93
2018 Diciembre	250	51	301
2018 Noviembre	526	21	547
2018 Octubre	353	29	382
2018 Septiembre	137	11	148
2018 Agosto	66	22	88
2018 Julio	58	12	70
2018 Junio	56	17	73
2018 Mayo	53	21	74
2018 Abril	86	18	104
2018 Marzo	67	21	88
2018 Febrero	60	12	72
2018 Enero	75	18	93
2017 Diciembre	61	14	75
2017 Noviembre	118	20	138
2017 Octubre	78	17	95
2017 Septiembre	85	21	106
2017 Agosto	89	35	124
2017 Julio	120	48	168
2017 Junio	122	29	151
2017 Mayo	109	33	142
2017 Abril	85	38	123
2017 Marzo	88	24	112
2017 Febrero	82	26	108
2017 Enero	92	17	109
2016 Diciembre	93	21	114
2016 Noviembre	104	18	122
2016 Octubre	66	13	79

Mostrar todo

Indexada en:

Síguenos:

Estadísticas

Indexada en:

Síguenos:

Estadísticas

Suscríbase a la newsletter