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"referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "Fernanda" "apellidos" => "Carvalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "Helena" "apellidos" => "Brito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 10 => array:3 [ "nombre" => "Mário" "apellidos" => "Lázaro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 11 => array:3 [ "nombre" => "Pedro" "apellidos" => "Leão Neves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Nephrology Department, Centro Hospitalar do Algarve – Faro Unit, Rua Leão Penedo, 8000-386 Faro, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Renal Pathology Laboratory, Nephrology Department, Hospital Curry Cabral, Rua da Beneficência, n.° 8, 1069-166 Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Internal Medicine Department, Centro Hospitalar do Algarve – Faro Unit, Rua Leão Penedo, 8000-386 Faro, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Gaucher y lupus: ¿una rara asociación?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gaucher disease (GD), is an autosomal recessive lysosomal storage disease that is due to mutations in the glucocerebrosidase (GC) gene, with a prevalence of 1/57,000 to 1/75,000 births worldwide<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and significantly more common among the Ashkenazi Jewish heritage.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> GD is categorized into three clinical types<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and the clinical manifestations result from the accumulation of the lipid-laden macrophages in the spleen, liver, bone, bone marrow,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> leading to impairment of central nervous system in the most severe cases.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although several reports are available related to the risk of GD patients developing other diseases like Parkinson's disease<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and increased rates of malignancies, particularly hematologic,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> systemic lupus erythematous (SLE) has not been described in association with GD.</p><p id="par0015" class="elsevierStylePara elsevierViewall">We report a case of a 32-year-old Caucasian woman diagnosed with GD type 1 at 17 years-old. She had a grandmother with GD, an uncle with SLE and a cousin with rheumatoid arthritis. There is no known Jewish heritage in her family. She was medicated with velaglucerase.</p><p id="par0020" class="elsevierStylePara elsevierViewall">With 30 years old, the patient developed malar-rash and chest eczema, associated with sun exposure. One year after she noticed worsening asthenia, anorexia, nausea, hair loss, myalgias, bilateral gonalgia, oral ulcers, Raynaud syndrome and arterial hypertension (TA 140/90<span class="elsevierStyleHsp" style=""></span>mmHg). The patient was referred to the nephrology unit with peripheral edema and the laboratory investigation showed parameters of ferropenic anemia (without signs of hemolysis), leukopenia, thrombocytopenia, elevated seric creatinine, hypoalbuminemia, active urinary sediment and nephrotic-range proteinuria observed in the 24<span class="elsevierStyleHsp" style=""></span>h urine sample (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The immune assays revealed positive antinuclear antibodies (ANA) and anti-Sjögren's-syndrome-related antigen A, elevated immunoglobulin (Ig) G (20.7<span class="elsevierStyleHsp" style=""></span>g/L) and IgA (4.64<span class="elsevierStyleHsp" style=""></span>g/L), circulating immunocomplexes (>100<span class="elsevierStyleHsp" style=""></span>μg<span class="elsevierStyleHsp" style=""></span>Eq/mL) and low serum complement (C3 0.16<span class="elsevierStyleHsp" style=""></span>g/L, C4 0.021<span class="elsevierStyleHsp" style=""></span>g/L, C1q 0.208<span class="elsevierStyleHsp" style=""></span>g/L). The complementary immunologic and serologic study was negative. Renal and abdominal ultrasounds showed normal sized kidneys, increased cortical echogenicity with maintained differentiation and mild/moderate homogeneous hepatosplenomegaly. Echocardiogram revealed thickened pericardium and nuclear magnetic resonance of the inferior members showed bone alterations and moderate intra-articular left knee and mild right knee effusion.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Kidney biopsy established the diagnosis of class IV-G lupus nephritis (LN) and the treatment according to KDIGO (Kidney Disease: Improving Global Outcomes) guideline<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> was started. Hydroxychloroquine was redrawn due to gastric intolerance. She was discharged 1 month after admission with serum creatinine 1.5<span class="elsevierStyleHsp" style=""></span>mg/dL, proteinuria 4500<span class="elsevierStyleHsp" style=""></span>mg observed in the 24<span class="elsevierStyleHsp" style=""></span>h urine sample (mg/24<span class="elsevierStyleHsp" style=""></span>h), complement levels arose and albuminemia was at the normal range (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Six months after discharge the patient is clinically stable, with normal renal function, proteinuria of 341<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h and an amelioration of complement. Anti-double stranded DNA was positive for the first time 6 months after discharge (182<span class="elsevierStyleHsp" style=""></span>U/mL) and decreased to 83<span class="elsevierStyleHsp" style=""></span>U/mL in the following 6 months (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><p id="par0030" class="elsevierStylePara elsevierViewall">We describe this case of a patient with GD and SLE simultaneously with the purpose of highlighting a possible immunologic proximity between these two diseases. Although the presence of renal pathology in GD is rather rare, it consists of varying degrees of proteinuria with or without renal insufficiency and it has been described in some patients associated with the accumulation of GC in form of Gaucher bodies in glomerular, mesangial, endothelial and interstitial cells of the kidney.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> It has been suggested that progressive accumulation of GC may trigger macrophage activation leading to chronic stimulation of the immune system.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Increasing clinical evidence suggests that the pathophysiology of classic GD is more complex and involves system-wide dysfunction of cell types other than macrophages.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Therefore, the immunological disturbances that occur in GD may function as a trigger to the development of SLE, bringing up the already existing doubt that the defects in lipid metabolism could contribute to the development of autoimmunity. In this particular case, clinical and laboratory results could led to a diagnosis of SLE: presence of 4 or more criteria, at least one clinical and one laboratorial Systemic Lupus International Collaborating Clinic (SLICC) criteria. However, and besides the clinical manifestations of malar rash associated with sun exposure, other like arthralgia, pancytopenia and hepatosplenomegaly were easily confounded with GD manifestations and the SLE diagnosis was not achieved until the renal manifestations occurred. The kidney biopsy revealing LN with positive ANA was preponderant to the diagnosis of SLE, according to SLICC criteria. Determining the class of LN was also important to guide the treatment by the histologic subtype, as the clinical presentation may not accurately reflect the severity of the histologic findings, and there was a positive clinical and laboratorial response.</p><p id="par0035" class="elsevierStylePara elsevierViewall">However, the relationship between GD and SLE is not yet established. The involvement of immune cells has been implicated, but the underlying molecular defect is poorly understood. Further studies are necessary to highlight the possible immunologic proximity between these two rare conditions.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Declaration</span><p id="par0040" class="elsevierStylePara elsevierViewall">Informed consent to publish individual data was obtained from the patient.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Declaration" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ANA, antinuclear antibodies; anti-SSA, anti-Sjögren's-syndrome-related antigen A; anti-dsDNA, anti-double stranded DNA; C3, complement 3; C4, complement 4.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Admission \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Discharge \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">6 months \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">12 months \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hb (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leukcocytes (×10<span class="elsevierStyleSup">9</span>/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2900 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7400 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5900 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4500 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelets (×10<span class="elsevierStyleSup">9</span>/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">87,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">168,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">237,000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">367,000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.38<span class="elsevierStyleHsp" style=""></span>→<span class="elsevierStyleHsp" style=""></span>2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Albumin (g/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary sediment – erythrocyts (μL<span class="elsevierStyleSup">−1</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">225 (15% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (8% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 (4% dysmorphic) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary proteins (mg/24<span class="elsevierStyleHsp" style=""></span>h) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7600 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4500 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">283 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ANA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-SSA (UA/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">786 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Positive \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-dsDNA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">182 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">83 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C3 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C4 (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.021 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.052 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.085 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1258440.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Laboratory parameters.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of lysosomal storage disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.J. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 4 | 0 | 4 |
2024 Octubre | 59 | 57 | 116 |
2024 Septiembre | 53 | 23 | 76 |
2024 Agosto | 74 | 67 | 141 |
2024 Julio | 61 | 24 | 85 |
2024 Junio | 56 | 44 | 100 |
2024 Mayo | 69 | 34 | 103 |
2024 Abril | 57 | 34 | 91 |
2024 Marzo | 52 | 30 | 82 |
2024 Febrero | 34 | 30 | 64 |
2024 Enero | 34 | 25 | 59 |
2023 Diciembre | 27 | 27 | 54 |
2023 Noviembre | 52 | 26 | 78 |
2023 Octubre | 49 | 26 | 75 |
2023 Septiembre | 35 | 29 | 64 |
2023 Agosto | 42 | 29 | 71 |
2023 Julio | 44 | 27 | 71 |
2023 Junio | 38 | 18 | 56 |
2023 Mayo | 51 | 34 | 85 |
2023 Abril | 37 | 17 | 54 |
2023 Marzo | 59 | 24 | 83 |
2023 Febrero | 53 | 32 | 85 |
2023 Enero | 34 | 25 | 59 |
2022 Diciembre | 60 | 46 | 106 |
2022 Noviembre | 70 | 33 | 103 |
2022 Octubre | 58 | 48 | 106 |
2022 Septiembre | 43 | 33 | 76 |
2022 Agosto | 69 | 47 | 116 |
2022 Julio | 38 | 43 | 81 |
2022 Junio | 53 | 33 | 86 |
2022 Mayo | 51 | 49 | 100 |
2022 Abril | 46 | 53 | 99 |
2022 Marzo | 56 | 48 | 104 |
2022 Febrero | 54 | 38 | 92 |
2022 Enero | 44 | 36 | 80 |
2021 Diciembre | 47 | 46 | 93 |
2021 Noviembre | 52 | 39 | 91 |
2021 Octubre | 54 | 60 | 114 |
2021 Septiembre | 41 | 51 | 92 |
2021 Agosto | 34 | 40 | 74 |
2021 Julio | 38 | 29 | 67 |
2021 Junio | 33 | 41 | 74 |
2021 Mayo | 45 | 42 | 87 |
2021 Abril | 96 | 100 | 196 |
2021 Marzo | 54 | 32 | 86 |
2021 Febrero | 52 | 39 | 91 |
2021 Enero | 46 | 23 | 69 |
2020 Diciembre | 26 | 13 | 39 |
2020 Noviembre | 36 | 22 | 58 |
2020 Octubre | 28 | 25 | 53 |
2020 Septiembre | 41 | 28 | 69 |
2020 Agosto | 42 | 23 | 65 |
2020 Julio | 26 | 23 | 49 |
2020 Junio | 28 | 52 | 80 |
2020 Mayo | 54 | 44 | 98 |
2020 Abril | 21 | 48 | 69 |
2020 Marzo | 38 | 40 | 78 |
2020 Febrero | 29 | 29 | 58 |
2020 Enero | 39 | 27 | 66 |
2019 Diciembre | 52 | 41 | 93 |
2019 Noviembre | 50 | 48 | 98 |
2019 Octubre | 33 | 13 | 46 |
2019 Septiembre | 43 | 25 | 68 |
2019 Agosto | 26 | 24 | 50 |
2019 Julio | 26 | 30 | 56 |
2019 Junio | 41 | 16 | 57 |
2019 Mayo | 30 | 34 | 64 |
2019 Abril | 64 | 38 | 102 |
2019 Marzo | 45 | 32 | 77 |
2019 Febrero | 31 | 22 | 53 |
2019 Enero | 22 | 23 | 45 |
2018 Diciembre | 185 | 54 | 239 |
2018 Noviembre | 366 | 39 | 405 |
2018 Octubre | 296 | 32 | 328 |
2018 Septiembre | 164 | 19 | 183 |
2018 Agosto | 125 | 21 | 146 |
2018 Julio | 116 | 17 | 133 |
2018 Junio | 122 | 22 | 144 |
2018 Mayo | 125 | 16 | 141 |
2018 Abril | 126 | 16 | 142 |
2018 Marzo | 106 | 15 | 121 |
2018 Febrero | 104 | 15 | 119 |
2018 Enero | 77 | 15 | 92 |
2017 Diciembre | 107 | 13 | 120 |
2017 Noviembre | 65 | 13 | 78 |
2017 Octubre | 55 | 18 | 73 |
2017 Septiembre | 69 | 10 | 79 |
2017 Agosto | 89 | 12 | 101 |
2017 Julio | 90 | 13 | 103 |
2017 Junio | 67 | 8 | 75 |
2017 Mayo | 81 | 23 | 104 |
2017 Abril | 69 | 12 | 81 |
2017 Marzo | 58 | 15 | 73 |
2017 Febrero | 85 | 12 | 97 |
2017 Enero | 85 | 14 | 99 |
2016 Diciembre | 104 | 12 | 116 |
2016 Noviembre | 103 | 12 | 115 |
2016 Octubre | 142 | 10 | 152 |
2016 Septiembre | 130 | 14 | 144 |
2016 Agosto | 6 | 1 | 7 |