array:24 [
  "pii" => "S0211699515001897"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2015.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-01"
  "aid" => "122"
  "copyright" => "Sociedad Española de Nefrología"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2016;36:51-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6137
    "formatos" => array:3 [
      "EPUB" => 346
      "HTML" => 4946
      "PDF" => 845
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0211699515002313"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.11.002"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "143"
    "copyright" => "Sociedad Española de Nefrología"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2016;36:57-62"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9262
      "formatos" => array:3 [
        "EPUB" => 299
        "HTML" => 8072
        "PDF" => 891
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Comparaci&#243;n entre bioimpedancia espectrosc&#243;pica y f&#243;rmula de Watson para medici&#243;n de volumen corporal en pacientes en di&#225;lisis peritoneal"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "57"
          "paginaFinal" => "62"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comparison of bioimpedance spectroscopy and the Watson formula for measuring body volume in patients on peritoneal dialysis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 943
              "Ancho" => 1550
              "Tamanyo" => 29699
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Volumen &#40;l&#41; calculado por f&#243;rmula de Watson &#40;Vw&#41; y BIS &#40;Vbis&#41; &#40;p&#160;&#60;&#160;0&#44;01&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Gonzalo Mart&#237;nez Fern&#225;ndez, Agust&#237;n Ortega Cerrato, Lourdes de la Vara Iniesta, Eva Oliver Galera, Carmen G&#243;mez Rold&#225;n, Juan P&#233;rez Mart&#237;nez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Gonzalo"
              "apellidos" => "Mart&#237;nez Fern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "Agust&#237;n"
              "apellidos" => "Ortega Cerrato"
            ]
            2 => array:2 [
              "nombre" => "Lourdes"
              "apellidos" => "de la Vara Iniesta"
            ]
            3 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "Oliver Galera"
            ]
            4 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "G&#243;mez Rold&#225;n"
            ]
            5 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "P&#233;rez Mart&#237;nez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251416000225"
        "doi" => "10.1016/j.nefroe.2016.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000225?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515002313?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515002313/v1_201602110042/es/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699515001903"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "123"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2016;36:42-50"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 11925
      "formatos" => array:3 [
        "EPUB" => 326
        "HTML" => 10566
        "PDF" => 1033
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Hiponatremia&#44; mortalidad y hemodi&#225;lisis&#58; una asociaci&#243;n no explicada"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "42"
          "paginaFinal" => "50"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Hyponatraemia&#44; mortality and haemodialysis&#58; An unexplained association"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2833
              "Ancho" => 2594
              "Tamanyo" => 230032
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Curvas de supervivencia &#40;Kaplan-Meier&#41; seg&#250;n el cuartil de la natremia&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Las curvas de supervivencia muestran el ritmo de fallecimientos seg&#250;n el cuartil &#40;C&#41; de Na en el que estuviese cada paciente a los 6 meses de entrada en las cl&#237;nicas FMC&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">El tiempo medio de supervivencia del C1 fue de 3&#44;21 a&#241;os IC &#40;3&#44;10-3&#44;31&#41;&#44; el del C2 de 3&#44;42 a&#241;os IC &#40;3&#44;32-3&#44;51&#41;&#44; el del C3 3&#44;51 a&#241;os IC &#40;3&#44;42-3&#44;60&#41; y por &#250;ltimo el del C4 de 3&#44;53 IC &#40;3&#44;44-3&#44;61&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael P&#233;rez-Garc&#237;a, In&#233;s Palomares, Jos&#233; Ignacio Merello, Rosa Ramos, Francisco Maduell, Manolo Molina, Pedro Aljama, Daniele Marcelli"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "P&#233;rez-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "In&#233;s"
              "apellidos" => "Palomares"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Ignacio"
              "apellidos" => "Merello"
            ]
            3 => array:2 [
              "nombre" => "Rosa"
              "apellidos" => "Ramos"
            ]
            4 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            5 => array:2 [
              "nombre" => "Manolo"
              "apellidos" => "Molina"
            ]
            6 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Aljama"
            ]
            7 => array:2 [
              "nombre" => "Daniele"
              "apellidos" => "Marcelli"
            ]
            8 => array:1 [
              "colaborador" => "en representaci&#243;n del grupo ORD"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251416000262"
        "doi" => "10.1016/j.nefroe.2016.02.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000262?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001903?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515001903/v1_201602110042/es/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Creatine-kinase and dialysis patients&#44; a helpful tool for stratifying cardiovascular risk&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "51"
        "paginaFinal" => "56"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Borja Quiroga, Almudena Vega, Soraya Abad, Maite Villaverde, Javier Reque, Juan Manuel L&#243;pez-G&#243;mez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Borja"
            "apellidos" => "Quiroga"
            "email" => array:1 [
              0 => "borjaqg&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Almudena"
            "apellidos" => "Vega"
          ]
          2 => array:2 [
            "nombre" => "Soraya"
            "apellidos" => "Abad"
          ]
          3 => array:2 [
            "nombre" => "Maite"
            "apellidos" => "Villaverde"
          ]
          4 => array:2 [
            "nombre" => "Javier"
            "apellidos" => "Reque"
          ]
          5 => array:2 [
            "nombre" => "Juan Manuel"
            "apellidos" => "L&#243;pez-G&#243;mez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Creatincinasa y pacientes en di&#225;lisis&#44; &#191;una herramienta &#250;til para estratificar el riesgo cardiovascular&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 893
            "Ancho" => 1610
            "Tamanyo" => 84690
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier plot illustrating cardiovascular events and CKMB values&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic kidney disease &#40;CKD&#41; is a major cardiovascular risk factor similar to congestive heart failure&#44; and this risk increases with the decline of renal function&#44; being maximum in dialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Several strategies have been proposed in order to detect those patients at high risk for developing cardiovascular events and for detecting subclinical alterations to be treated&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a> Current guidelines recommend measuring cardiac biomarkers&#44; specifically troponins and natriuretic peptides&#44; as they are usually increased in our patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;4</span></a> If possible&#44; ecocardiography should be performed periodically although recommended intervals vary in function of the guideline&#46; Some studies have found a strong association between cardiac biomarkers&#44; ecocardiographic findings and prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">On one hand&#44; serum cardiac biomarkers are increased in virtually all CKD patients especially in dialysis and those who have higher values have poorer prognosis&#46; On the other hand&#44; when these biomarkers are adjusted by ecocardiographic findings &#40;for example&#44; diastolic and systolic dysfunction and left ventricular hypertrophy&#41; they lose their independent prediction value&#44; suggesting their role as observer of cardiac damage&#44; usually subclinically&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5&#44;6</span></a> Most importantly&#44; increased cardiac biomarkers seems to be universal with high sensitivity assays&#44; but those with higher values have a better association to postmortem cardiac damage or with coronary lesions demonstrated by angiography&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">However&#44; and although several authors have proposed different cut-offs for stratifying the cardiovascular risk&#44; lack of agreement has been reached&#44; suggesting that probably those markers must be interpreted as continuous variables&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">One important biomarker has not been widely studied in CKD patients until date&#44; creatine kinase MB isoenzyme &#40;CKMB&#41;&#46; In general population&#44; its sensitivity in acute coronary syndromes is inferior to troponins&#46; However&#44; due to its small half-life&#44; current guidelines recommend its use for monitoring cardiac damage after revascularization as they present a good correlation with re-infarction&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Many patients with CKD have been excluded from studies about CKMB due to its difficult interpretation when renal function is impaired&#46; Published series yield controversial data in terms of prevalence of raise serum values and their use in ischemic heart disease&#46; However&#44; it seems to have the same value as prognosis marker in re-infarction in patients with renal impairment&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">11&#44;12</span></a> The aim of the present study was to analyze the prognosis value of CKMB in a cohort of dialysis patients and also its related factors&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 211 patients on hemodialysis in a single center were enrolled in the restrospective study&#46; Stable patients with no cardiovascular events in the 4 weeks before serum determinations were included&#46; During the follow up &#91;39 &#40;19&#8211;56&#41; months&#93;&#44; patients with changes in hemodialysis parameters&#44; transferred to another center or transplanted were censored&#46; Investigations were in accordance with the Declaration of Helsinki&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Baseline characteristics and measurements</span><p id="par0035" class="elsevierStylePara elsevierViewall">Baseline characteristics were recorded&#44; including age&#44; sex&#44; presence of diabetes mellitus&#44; peripheral vascular disease&#44; previous cardiovascular disease &#40;congestive heart failure determined by echocardiography within the three previous months&#44; myocardial infarction&#44; cerebrovascular disease&#41;&#44; dialysis vintage and data regarding the vascular access&#46; Basally&#44; we measured C-reactive protein &#40;CRP&#41;&#44; high sensitivity troponin T &#40;hsTnT&#41;&#44; CK-MB and N-terminal prohormone of brain natriuretic peptide &#40;Nt-proBNP&#41;&#46; All included patients had the same hemodialysis therapy protocol&#58; 4<span class="elsevierStyleHsp" style=""></span>h&#44; three times per week&#46; Routine clinical and biochemical variables were measured by standardized methods on autoanalyzers&#46; CKMB and HsTnT were measured on a Roche&#47;Hitachi Cobas E411 analyzer&#46; Factors related to higher values of CKMB were analyzed&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Echocardiography</span><p id="par0040" class="elsevierStylePara elsevierViewall">Echocardiography was recorded in stable patients who had a less than 6-month one before obtaining the sample and within 24<span class="elsevierStyleHsp" style=""></span>h after the last hemodialysis on the day between mid-week dialysis sessions&#46; Diastolic dysfunction was defined as <span class="elsevierStyleItalic">e</span>&#8242; &#40;early mitral annulus velocity&#41; less than 8<span class="elsevierStyleHsp" style=""></span>cm&#47;s&#44; average <span class="elsevierStyleItalic">E</span> &#40;early mitral flow&#41;&#47;<span class="elsevierStyleItalic">e</span>&#8242; over 8&#44; LAVi &#40;left atrium volume index&#41; over 28<span class="elsevierStyleHsp" style=""></span>mL&#47;m<span class="elsevierStyleSup">2</span> or Ar<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>A &#40;time difference between duration of the pulmonary venous atrial reversal wave and duration of the A wave&#41; over 30<span class="elsevierStyleHsp" style=""></span>ms&#46; Systolic dysfunction in turn was defined as a left ventricle ejection fraction of under 45&#37;&#46; The left ventricular mass index &#40;LVMi&#41; was estimated by Devereux&#39;s formula&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Outcomes</span><p id="par0045" class="elsevierStylePara elsevierViewall">New cardiovascular events &#40;ischemic or hemorrhagic cerebrovascular accident&#44; cardiac event &#91;including myocardial infarction and&#47;or congestive heart failure&#93;&#44; peripheral vascular events and other ischemic events&#41; were recorded during follow-up&#46; We analyzed the predictor value of CKMB for cardiovascular events&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical procedures</span><p id="par0050" class="elsevierStylePara elsevierViewall">Values are expressed as the mean &#40;SD&#41; or median &#40;IQR&#41;&#46; We established linear regression models for evaluating the distribution of the studied variables according to CKMB levels&#46; To assess the diagnosis value of the different cardiac markers we used the receiving operator characteristics &#40;ROC&#41; curve for each one&#46; Correlations between cardiac markers were performed using Pearson test&#46; Multivariate analysis was performed by Cox regression&#46; Variables were analyzed and only those considered confounders were entered in the final Cox regression model&#46; Different models were used&#44; including CKMB for its different values&#44; in order to determine the best cut-off to assess cardiovascular risk&#46; Cardiovascular events were analyzed using Kaplan&#8211;Meier plots&#44; and survival curves were compared using the log-rank test&#46; We used the integrated discrimination improvement &#40;IDI&#41;&#44; as described by Pencina et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> to interpret the incremental value of CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL added to a risk prediction model including age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; NtproBNP and HsTnT&#46; IDI is a measure of improvement in model performance and represents the difference between discrimination slopes of two competing models&#46; We calculated the relative IDI&#44; which expresses the relative increase in separation of events and non-events from the separation achieved in the base model &#40;i&#46;e&#46;&#44; the difference in discrimination slopes is expressed as a proportion of the discrimination slope of the base model&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> All statistical analyses were performed with the SPSS<span class="elsevierStyleSup">&#174;</span> 18&#46;0 statistical package &#40;Chicago&#44; IL&#44; USA&#41;&#46; A <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Baseline characteristics and factors associated with increased levels</span><p id="par0055" class="elsevierStylePara elsevierViewall">A total of 211 prevalent hemodialysis patients were included in this study to be followed for 39 &#40;19&#8211;56&#41; months&#46; One hundred and twenty-three patients &#40;58&#46;3&#37;&#41; were male&#44; with a median age of 73 &#40;60&#8211;80&#41;&#46; Baseline characteristic are showed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The median value of CKMB was 1 &#40;1&#8211;2&#41; ng&#47;mL&#44; with the following distribution&#58; 13 patients &#40;6&#46;3&#37;&#41; have basal levels of 0<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 121 &#40;58&#46;5&#41; have 1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 56 &#40;27&#46;1&#37;&#41; have 2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 13 &#40;6&#46;3&#37;&#41; have 3<span class="elsevierStyleHsp" style=""></span>ng&#47;dL and only 4 &#40;1&#46;9&#41; have 4<span class="elsevierStyleHsp" style=""></span>ng&#47;dL&#46; In <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; baseline characteristics are shown in the different strata according to CKMB values&#46; No patients exceeded the normal range of our laboratory &#40;0&#8211;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; Univariate analysis revealed that higher levels of CKMB were associated to previous heart disease&#44; diabetes mellitus&#44; peripheral vascular disease and systolic and diastolic dysfunction &#40;data shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Correlation with other cardiac biomarkers</span><p id="par0060" class="elsevierStylePara elsevierViewall">Correlation between cardiac biomarkers showed a positive and significant one between CKMB and NtproBNP &#40;0&#46;163&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;020&#41; and between NtproBNP and HsTnT &#40;0&#46;635&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; No significant correlation was established between CKMB and HsTnT&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Cardiovascular events and predictive value of CKMB</span><p id="par0065" class="elsevierStylePara elsevierViewall">A total of 94 cardiovascular events were recorded during the follow up&#46; Cardiac event was the most common event &#40;79&#46;8&#37;&#41;&#44; followed by peripheral vascular disease &#40;8&#46;5&#37;&#41;&#44; cerebrovascular event &#40;6&#46;4&#37;&#41;&#46; Diabetic patients did not show higher incidence of cardiovascular events in our cohort &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;3&#41;&#44; although they have a trend of higher prevalence of diastolic dysfunction &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;056&#41;&#46; The area under the ROC curve for cardiovascular events was greater for HsTnT &#40;0&#46;723&#41; and Nt-proBNP &#40;0&#46;688&#41; than CKMB &#40;0&#46;587&#41;&#46; CKMB levels were associated to the development of cardiovascular events during follow up &#91;HR 1&#46;46 95&#37; CI &#40;1&#46;15&#8211;1&#46;87&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#93; as well as the other factors shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; In <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; the survival curve shows the association between cardiovascular events and the different CKMB values confirming that higher levels condition worse prognosis &#40;logRank 8&#46;8&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; Multivariate Cox regression model adjusted for several cofounders and variables showed that CKMB levels &#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL independently increased cardiovascular risk in our cohort of hemodialysis patients&#46; A non-significant trend was observed if the CKMB cut-off was &#8805;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">IDI analysis was performed to assess the improvement in risk discrimination of adding CKMB &#40;&#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; to a cardiovascular event risk prediction model including age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; NtproBNP and HsTnT&#46; This analysis comprised all individuals and used NtproBNP and HsTnT as dichotomous variables&#46; Adding CKMB resulted in 17&#37; improved risk discrimination for cardiovascular events &#40;IDI 0&#46;026 &#91;0&#46;004&#8211;0&#46;053&#93;&#59; relative IDI 9&#46;9&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Our study demonstrates that CK-MB is a useful marker for stratifying cardiovascular risk in dialysis patients&#44; even in normal range values&#46; Importantly for acute situations&#44; hemodialysis patients do not have basally elevated higher levels&#44; so this marker could be useful in the differential diagnosis of chest pain as marker of acute ischemia&#46; Supporting this fact&#44; and different from other cardiac markers&#44; CKMB does not appear to be influenced by the dialysis&#44; so its levels remain stable after and before&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> However&#44; and although CKMB has a short half-life&#44; its levels are correlated to HsTnT and NtproBNP and their values are associated to other cardiovascular risk factors&#46; One study conducted by McCullong et al&#46; that included 817 consecutive patients with chest pain&#44; shown that those with confirmed acute myocardial infarction &#40;AMI&#41; suffer a CKMB rise irrespective of the renal function&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> Curiously&#44; in this study&#44; those patients without final diagnosis of AMI showed significant different basal levels of CKMB between groups &#40;inversely correlated with glomerular filtration and maximum in dialysis patients&#41;&#44; unlike those with final diagnosis of AMI&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The first report regarding the influence of hemodialysis in CKMB levels was published in 1984 by Jaffe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> In this study that included 88 patients&#44; authors demonstrated normal levels of CKMB for the most part of the studied sample&#46; Although some authors differ in their opinions on this regard&#44; the CHANCE study confirmed not only this situation but also that levels of CK-MB could be influenced by the presence of history of ischemic heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">19&#8211;22</span></a> Our results agree with this finding&#44; and with the association to age &#40;we could only demonstrate a trend with this value&#41; and troponins&#46; Cardiovascular risk factors as peripheral vascular disease&#44; diabetes mellitus and Nt-proBNP seem to be associated to CKMB&#44; above all with values &#8805;3<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We assessed the predictive value of CKMB for cardiovascular events&#46; Our data suggests that CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL give a poor cardiovascular prognosis in dialysis patients&#46; Results of CHANCE study agree with our results&#44; showing an increased risk of major cardiovascular events in those patients with CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; in a 2-year follow up&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">However&#44; CKMB is not the only marker but the less studied in this regard&#44; although it is cheap and easily applicable in routine clinical&#46; In adjusted multivariate analysis&#44; those patients with HsTnT and NtproBNP over the median and CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL enhanced its cardiovascular risk more than threefold&#44; in comparison to CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL alone&#46; Several studies have found an association between cardiac markers and prognosis&#44; and now we know that this situation reveals a true clinical or subclinical cardiac damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;23</span></a> In fact&#44; in our study&#44; CKMB demonstrated an association with previous heart disease and also with systolic and diastolic dysfunction&#46; Previous published data has only been able to remark an association to LVH in patients with renal function impairment&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The present study has some limitations&#46; Firstly&#44; the typical limitations of a retrospective design&#46; Secondly&#44; not all the patients had a echocardiograph image and they were performed by different specialists&#46; This bias was partially avoided by the use of the same criteria for the definitions of each entity &#40;systolic and diastolic dysfunction and LVH&#41;&#46; Thirdly&#44; vascular calcifications were not assessed as recommended in recent guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a> Lastly&#44; the study was performed in one center&#44; and results must be confirmed in bigger sample size&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In conclusion&#44; CKMB is a good marker for stratifying cardiovascular risk in hemodialysis patients even in the normal range of their values&#46; We recommend measuring several cardiac markers&#44; at least two&#44; in order to get better predictive values&#46; As basal levels of CKMB are not elevated in these patients&#44; further studies are required to confirm their value in acute coronary syndromes&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflict of interests</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres604096"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background and aims"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec618270"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres604097"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes y objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec618269"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Baseline characteristics and measurements"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Echocardiography"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Outcomes"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Statistical procedures"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0040"
          "titulo" => "Results"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Baseline characteristics and factors associated with increased levels"
            ]
            1 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Correlation with other cardiac biomarkers"
            ]
            2 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Cardiovascular events and predictive value of CKMB"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of interests"
        ]
        9 => array:2 [
          "identificador" => "xack203332"
          "titulo" => "Acknowledgment"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-12-10"
    "fechaAceptado" => "2015-03-06"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec618270"
          "palabras" => array:4 [
            0 => "Cardiac biomarkers"
            1 => "Cardiovascular"
            2 => "CKMB"
            3 => "Hemodialysis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec618269"
          "palabras" => array:4 [
            0 => "Biomarcadores cardiacos"
            1 => "Cardiovascular"
            2 => "CKMB"
            3 => "Hemodi&#225;lisis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and aims</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemodialysis patients have an enhanced risk for cardiovascular events&#46; Cardiac biomarkers provide useful information for stratifying their risk&#46; However the prognosis value of creatine kinase MB isoenzyme &#40;CKMB&#41; has not yet been validated in this population&#46; The aim of the present study is to determine the predictable value of CK-MB in hemodialysis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cohort of 211 hemodialysis patients &#40;58&#46;3&#37; male&#44; median age 73 &#40;60&#8211;80&#41; years&#41; were followed for 39 &#40;19&#8211;56&#41; months&#46; Cardiac biomarkers including CKMB were recorded at baseline&#46; Factors associated to CKMB and prognosis value of this biomarker was studied&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The median value of CKMB was 1 &#40;1&#8211;2&#41; ng&#47;mL with no patient exceeding normal laboratory values&#46; Previous heart disease&#44; diabetes mellitus&#44; peripheral vascular disease and systolic and diastolic dysfunction were associated with higher levels of CKMB&#46; Ninety-four patients &#40;44&#46;5&#37;&#41; cardiovascular events were recorded&#46; CKMB levels &#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL was independently associated to cardiovascular events during the follow up after adjusting&#46; Adding CKMB to a model including several variables for predicting cardiovascular events&#44; resulted in 17&#37; improvement in risk discrimination &#40;IDI&#41; with a relative IDI of 9&#46;9&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CKMB is a good marker for stratifying cardiovascular risk in hemodialysis patients and adds prognosis information to other well known independent predictors for cardiovascular events&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and aims"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los pacientes en hemodi&#225;lisis presentan un riesgo cardiovascular elevado&#46; Los biomarcadores cardiacos otorgan informaci&#243;n &#250;til para estratificar dicho riesgo cardiovascular&#46; Sin embargo&#44; el valor pron&#243;stico de la isoenzima MB de la creatincinasa &#40;CKMB&#41; no ha sido a&#250;n validado en esta poblaci&#243;n&#46; El objetivo del presente trabajo es evaluar el valor predictivo de CKMB en una poblaci&#243;n en hemodi&#225;lisis&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Una cohorte de 211 pacientes en hemodi&#225;lisis &#40;58&#44;3&#37; varones&#44; con una edad media de 73 &#91;60&#8211;80&#93; a&#241;os&#41; fueron seguidos durante 39 &#40;19&#8211;56&#41; meses&#46; Se recogieron basalmente los valores de diferentes biomarcadores cardiacos incluyendo CKMB&#46; Se evaluaron los factores asociados a niveles m&#225;s elevados de CKMB&#44; as&#237; como su valor predictivo independiente&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La mediana de CKMB fue de 1 &#40;1&#8211;2&#41; ng&#47;mL&#46; Todos los pacientes presentaron valores dentro de los establecidos de referencia en la poblaci&#243;n normal&#46; Los antecedentes de cardiopat&#237;a&#44; diabetes mellitus&#44; enfermedad perif&#233;rica y la disfunci&#243;n diast&#243;lica y sist&#243;lica se asociaron a niveles m&#225;s elevados de CKMB&#46; Un total de 94 pacientes &#40;44&#44;5&#37;&#41; presentaron un evento cardiovascular&#46; Los niveles de CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL se asociaron de manera independiente a presentar eventos cardiovasculares durante el seguimiento tras el ajuste para diferentes factores&#46; La adici&#243;n de CKMB a un modelo predictor con diferentes factores gener&#243; una mejor&#237;a del 17&#37; en la estimaci&#243;n de la probabilidad de forma lineal &#40;IDI&#41; con un IDI relativo del 9&#44;9&#37; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">CKMB es un buen marcador para estratificar el riesgo cardiovascular en los pacientes de hemodi&#225;lisis y a&#241;ade informaci&#243;n en cuanto al pron&#243;stico cuando se combina con otros predictores de eventos cardiovasculares&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 893
            "Ancho" => 1610
            "Tamanyo" => 84690
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier plot illustrating cardiovascular events and CKMB values&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;60-80&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex male&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123 &#40;58&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">History of heart disease&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;42&#46;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;32&#46;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64 &#40;30&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous echocardiogram&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">166 &#40;78&#46;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Left ventricular hypertrophy&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;63&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Systolic dysfunction&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;14&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Diastolic dysfunction&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60 &#40;36&#46;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous dialysis vintage &#40;months&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;43-128&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Vascular access</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- Autologous</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- PTFE</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- Permanent catheter</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">116 &#40;55&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>65 &#40;31&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>30 &#40;14&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;35-90&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#40;ng&#47;mL&#41;</span><span class="elsevierStyleBold">- 0 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 1 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 2 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 3 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 4 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1-2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>13 &#40;6&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>121 &#40;58&#46;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>56 &#40;27&#46;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>13 &#40;6&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>4 &#40;1&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4994 &#40;2237-15036&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;0 &#40;4&#46;0-15&#46;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989330.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mean &#40;standart deviation&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Median &#40;interquartile range&#41;&#46; High sentivity troponin T &#40;hsTnT&#41;&#44; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 0 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;13&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 1 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;121&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 2 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;56&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#8805; 3 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;17&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P for trend</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;62-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75 &#40;56-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73 &#40;63-78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;70-64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex male &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous heart disease &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Left ventricular hypertrophy &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;181&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Systolic dysfunction &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diastolic dysfunction &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous dialysis vintage &#40;months&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">107 &#40;38-132&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82 &#40;46-128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85 &#40;31-148&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62 &#40;40-122&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#40;ng&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71 &#40;39-88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;30-74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67 &#40;42-128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89 &#40;44-144&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;ng&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6814 &#40;3894-12466&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4112 &#40;2159-14244&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7293 &#40;2506-17008&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10524 &#40;4265-20146&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;0 &#40;6&#46;5-27&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;0 &#40;3&#46;0-14&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;0 &#40;4&#46;0-12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;0 &#40;6&#46;0-22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989331.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Median &#40;interquartile range&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Percentage over the patients with a previous echocardiogram &#40;166&#41;&#46; Abbrev&#46;&#58; High sentivity troponin T &#40;hsTnT&#41;&#44; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Descriptive of baseline characteristics according to CKMB values&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HR &#40;95&#37; CI&#41; &#61; Hazard ratio &#40;95&#37; Confidence interval&#41;&#46; &#40;F&#47;M&#41;&#61;&#40;female&#47;male&#41;&#46; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44;High sentivity troponin T &#40;hsTnT&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;02 &#40;1&#46;01-1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex &#40;male&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;11 &#40;0&#46;73-1&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;619&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous Heart Disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;99 &#40;3&#46;16-7&#46;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes Mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;23 &#40;0&#46;81-1&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;53 &#40;1&#46;01-2&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Dialysis Vintage &#40;per month&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;00 &#40;0&#46;99-1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;825&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Vascular access &#40;autologus fistualae&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;96 &#40;0&#46;64-1&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;860&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Left ventricular hypertrophy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;64 &#40;0&#46;94-2&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;080&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Systolic dysfunction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;72 &#40;1&#46;52-4&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diastolic dysfunction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;59 &#40;1&#46;52-4&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CK-MB &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;46 &#40;1&#46;15-1&#46;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#8805; 56 ng&#47;L &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;52 &#40;1&#46;47-4&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;mcg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;01 &#40;1&#46;01-1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;01 &#40;0&#46;96-1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;578&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989332.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Autologous vascular access has been codified as 0 and non-autologous as 1&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Factors associated with cardiovascular events during follow up &#40;unadjusted Cox regression&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#61; 0 &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ref</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ref</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#8805; 1 ng&#47;mL</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;20 &#40;0&#46;88-5&#46;51&#41;2&#46;84 &#40;1&#46;79-4&#46;53&#41;1&#46;98 &#40;1&#46;23-3&#46;17&#41;2&#46;71 &#40;1&#46;74-4&#46;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;092&#60;0&#46;0010&#46;005&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#8805; 2 &#40;ng&#47;mL&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;63 &#40;1&#46;06-2&#46;53&#41;3&#46;01 &#40;1&#46;90-4&#46;81&#41;1&#46;82 &#40;1&#46;11-2&#46;99&#41;3&#46;24 &#40;1&#46;92-5&#46;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;027&#60;0&#46;0010&#46;016&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989333.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Cox regression model adjusted for age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide</span> and high sentivity troponin T&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Cox regression model adjusted for age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Predictor value of the different values of CK-MB for cardiovascular events during follow up &#40;adjusted Cox regression&#41; alone and in combination with the other cardiac biomarkers&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T predicts mortality in patients with end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Dierkes"
                            1 => "U&#46; Domrose"
                            2 => "S&#46; Westphal"
                            3 => "A&#46; Ambrosch"
                            4 => "H&#46;P&#46; Bosselmann"
                            5 => "K&#46;H&#46; Neumann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2000"
                        "volumen" => "102"
                        "paginaInicial" => "1964"
                        "paginaFinal" => "1969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11034946"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606692908"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence-based cardiology in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Allon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2013060632"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2013"
                        "volumen" => "24"
                        "paginaInicial" => "1934"
                        "paginaFinal" => "1943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24136920"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic utility of cardiac biomarkers in dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;Y&#46; Wang"
                            1 => "C&#46; Wai-Kei Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-139X.2012.01099.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "388"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22748194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponins and chronic kidney disease&#44; what do we know&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Quiroga"
                            1 => "D&#46; Arroyo"
                            2 => "M&#46; Goicoechea"
                            3 => "S&#46; Garcia de Vinuesa"
                            4 => "J&#46; Lu&#241;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Cardiovasc Res"
                        "fecha" => "2013"
                        "volumen" => "2"
                        "paginaInicial" => "5"
                        "itemHostRev" => array:3 [
                          "pii" => "S014067361160874X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic dysfunction and high levels of new cardiac biomarkers as risk factors for cardiovascular events and mortality in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Quiroga"
                            1 => "M&#46; Villaverde"
                            2 => "S&#46; Abad"
                            3 => "A&#46; Vega"
                            4 => "J&#46; Reque"
                            5 => "J&#46;M&#46; L&#243;pez-G&#243;mez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000354080"
                      "Revista" => array:7 [
                        "tituloSerie" => "Blood Purif"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "98"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24051551"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674909015383"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of echocardiography in observational clinical trials&#58; the EURECA-m registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Sicari"
                            1 => "L&#46; Gargani"
                            2 => "A&#46; Wiecek"
                            3 => "A&#46; Covic"
                            4 => "D&#46; Goldsmith"
                            5 => "G&#46; Suleymanlar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs399"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "19"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23048175"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602116795"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T in hemodialyzed patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Ooi"
                            1 => "A&#46;A&#46; House"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1998"
                        "volumen" => "44"
                        "paginaInicial" => "1410"
                        "paginaFinal" => "1416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9665417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T and C-reactive protein for predicting prognosis&#44; coronary atherosclerosis&#44; and cardiomyopathy in patients undergoing long-term hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; deFilippi"
                            1 => "S&#46; Wasserman"
                            2 => "S&#46; Rosanio"
                            3 => "E&#46; Tiblier"
                            4 => "H&#46; Sperger"
                            5 => "M&#46; Tocchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.290.3.353"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2003"
                        "volumen" => "290"
                        "paginaInicial" => "353"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12865376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2012 ACCF&#47;AHA focused update incorporated into the ACCF&#47;AHA 2007 guidelines for the management of patients with unstable angina&#47;non-ST-elevation myocardial infarction&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Anderson"
                            1 => "C&#46;D&#46; Adams"
                            2 => "E&#46;M&#46; Antman"
                            3 => "C&#46;R&#46; Bridges"
                            4 => "R&#46;M&#46; Califf"
                            5 => "D&#46;E&#46; Casey Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.01.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2012"
                        "volumen" => "61"
                        "paginaInicial" => "e179"
                        "paginaFinal" => "e347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23639841"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ACCF&#47;AHA guideline for the management of ST-elevation myocardial infarction&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;T&#46; O&#8217;Gara"
                            1 => "F&#46;G&#46; Kushner"
                            2 => "D&#46;D&#46; Ascheim"
                            3 => "D&#46;E&#46; Casey Jr&#46;"
                            4 => "M&#46;K&#46; Chung"
                            5 => "J&#46;A&#46; de Lemos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIR.0b013e3182742cf6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2013"
                        "volumen" => "127"
                        "paginaInicial" => "e362"
                        "paginaFinal" => "e425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23247304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic value of cardiac markers in ESRD&#58; Chronic Hemodialysis and New Cardiac Markers Evaluation &#40;CHANCE&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Iliou"
                            1 => "C&#46; Fumeron"
                            2 => "M&#46;O&#46; Benoit"
                            3 => "P&#46; Tuppin"
                            4 => "V&#46;M&#46; Calonge"
                            5 => "N&#46; Moatti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "513"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12955679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparison of cardiac biomarkers positivities in hemodialysis patients without acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Korkmaz"
                            1 => "G&#46; Sasak"
                            2 => "A&#46; Celik"
                            3 => "E&#46; Kurto&#287;lu"
                            4 => "M&#46; G&#252;rger"
                            5 => "K&#46;B&#46; Bursal&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.585264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "578"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular hypertrophy and function in high&#44; normal&#44; and low-renin forms of essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;B&#46; Devereux"
                            1 => "D&#46;D&#46; Savage"
                            2 => "J&#46;I&#46; Drayer"
                            3 => "J&#46;H&#46; Laragh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1982"
                        "volumen" => "4"
                        "paginaInicial" => "524"
                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6218079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Pencina"
                            1 => "R&#46;B&#46; D&#8217;Agostino Sr&#46;"
                            2 => "E&#46;W&#46; Steyerberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/sim.4085"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "2011"
                        "volumen" => "30"
                        "paginaInicial" => "11"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21204120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpreting incremental value of markers added to risk prediction models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Pencina"
                            1 => "R&#46;B&#46; D&#8217;Agostino"
                            2 => "K&#46;M&#46; Pencina"
                            3 => "A&#46;C&#46; Janssens"
                            4 => "P&#46; Greenland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kws207"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2012"
                        "volumen" => "176"
                        "paginaInicial" => "473"
                        "paginaFinal" => "481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22875755"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067360861452X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of hemodialysis on cardiac enzyme levels and echocardiographic parameters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ingec"
                            1 => "E&#46;G&#46; Oguz"
                            2 => "T&#46; Yildirim"
                            3 => "T&#46; Ulas"
                            4 => "M&#46; Horoz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5301/ijao.5000333"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Artif Organs"
                        "fecha" => "2014"
                        "volumen" => "37"
                        "paginaInicial" => "513"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24970560"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674910002897"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of multiple cardiac biomarkers measured in the emergency department in patients with chronic kidney disease and chest pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; McCullough"
                            1 => "R&#46;M&#46; Nowak"
                            2 => "C&#46; Foreback"
                            3 => "G&#46; Tokarski"
                            4 => "M&#46;C&#46; Tomlanovich"
                            5 => "N&#46;E&#46; Khoury"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acad Emerg Med"
                        "fecha" => "2002"
                        "volumen" => "9"
                        "paginaInicial" => "1389"
                        "paginaFinal" => "1396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unmasking artifactual increases in creatine kinase isoenzymes in patients with renal failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;S&#46; Jaffe"
                            1 => "C&#46; Ritter"
                            2 => "V&#46; Meltzer"
                            3 => "H&#46; Harter"
                            4 => "R&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lab Clin Med"
                        "fecha" => "1984"
                        "volumen" => "104"
                        "paginaInicial" => "193"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6747438"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum enzyme levels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;D&#46; Vaziri"
                            1 => "D&#46; Kayichian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Handbook of dialysis"
                        "paginaInicial" => "482"
                        "paginaFinal" => "489"
                        "edicion" => "4th ed&#46;"
                        "serieFecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparison of cardiac biomarkers positivities in hemodialysis patients without acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Korkmaz"
                            1 => "G&#46; Sa&#351;ak"
                            2 => "A&#46; Celik"
                            3 => "E&#46; Kurto&#287;lu"
                            4 => "M&#46; G&#252;rger"
                            5 => "K&#46;B&#46; Bursal&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.585264"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "578"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663388"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674912005234"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do cardiac troponins provide prognostic insight in hemodialysis patients&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;B&#46; Choy"
                            1 => "P&#46;W&#46; Armstrong"
                            2 => "R&#46;A&#46; Ulan"
                            3 => "P&#46;M&#46; Campbell"
                            4 => "S&#46; Gourishankar"
                            5 => "C&#46;I&#46; Prosser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Cardiol"
                        "fecha" => "2003"
                        "volumen" => "19"
                        "paginaInicial" => "907"
                        "paginaFinal" => "911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12876611"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients&#58; Chronic Haemodialysis and New Cardiac Markers Evaluation &#40;CHANCE&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Iliou"
                            1 => "C&#46; Fumeron"
                            2 => "M&#46;O&#46; Benoit"
                            3 => "P&#46; Tuppin"
                            4 => "C&#46;L&#46; Courvoisier"
                            5 => "V&#46;M&#46; Calonge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "1452"
                        "paginaFinal" => "1458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11427640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac markers in different degrees of chronic kidney disease&#58; influence of inflammation and previous heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Quiroga"
                            1 => "M&#46; Goicoechea"
                            2 => "S&#46; Garc&#237;a de Vinuesa"
                            3 => "E&#46; Verde"
                            4 => "U&#46; Verdalles"
                            5 => "C&#46; Yuste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2012"
                        "volumen" => "139"
                        "paginaInicial" => "98"
                        "paginaFinal" => "102"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674909003479"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular calcification in chronic kidney disease&#58; are biomarkers useful for probing the pathobiology and the health risks of this process in the clinical scenario&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Liabeuf"
                            1 => "H&#46; Okazaki"
                            2 => "L&#46; Desjardins"
                            3 => "D&#46; Fliser"
                            4 => "D&#46; Goldsmith"
                            5 => "A&#46; Covic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "1275"
                        "paginaFinal" => "1284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24009287"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack203332"
        "titulo" => "Acknowledgment"
        "texto" => "<p id="par0110" class="elsevierStylePara elsevierViewall">We would like to thank Vilma E&#46; Pacheco for proofreading the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515001897/v1_201602110042/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003600000001/v1_201602110042/S0211699515001897/v1_201602110042/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001897?idApp=UINPBA000064"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Original article
Creatine-kinase and dialysis patients, a helpful tool for stratifying cardiovascular risk?
Creatincinasa y pacientes en diálisis, ¿una herramienta útil para estratificar el riesgo cardiovascular?
Borja Quiroga
Autor para correspondencia
borjaqg@gmail.com

Corresponding author.
, Almudena Vega, Soraya Abad, Maite Villaverde, Javier Reque, Juan Manuel López-Gómez
Servicio de Nefrología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Leído
11340
Veces
se ha leído el artículo
2790
Total PDF
8550
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0211699515001897"
  "issn" => "02116995"
  "doi" => "10.1016/j.nefro.2015.10.004"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-01"
  "aid" => "122"
  "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia. 2016;36:51-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6137
    "formatos" => array:3 [
      "EPUB" => 346
      "HTML" => 4946
      "PDF" => 845
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S0211699515002313"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.11.002"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "143"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2016;36:57-62"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 9262
      "formatos" => array:3 [
        "EPUB" => 299
        "HTML" => 8072
        "PDF" => 891
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Comparaci&#243;n entre bioimpedancia espectrosc&#243;pica y f&#243;rmula de Watson para medici&#243;n de volumen corporal en pacientes en di&#225;lisis peritoneal"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "57"
          "paginaFinal" => "62"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comparison of bioimpedance spectroscopy and the Watson formula for measuring body volume in patients on peritoneal dialysis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 943
              "Ancho" => 1550
              "Tamanyo" => 29699
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Volumen &#40;l&#41; calculado por f&#243;rmula de Watson &#40;Vw&#41; y BIS &#40;Vbis&#41; &#40;p&#160;&#60;&#160;0&#44;01&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Gonzalo Mart&#237;nez Fern&#225;ndez, Agust&#237;n Ortega Cerrato, Lourdes de la Vara Iniesta, Eva Oliver Galera, Carmen G&#243;mez Rold&#225;n, Juan P&#233;rez Mart&#237;nez"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Gonzalo"
              "apellidos" => "Mart&#237;nez Fern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "Agust&#237;n"
              "apellidos" => "Ortega Cerrato"
            ]
            2 => array:2 [
              "nombre" => "Lourdes"
              "apellidos" => "de la Vara Iniesta"
            ]
            3 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "Oliver Galera"
            ]
            4 => array:2 [
              "nombre" => "Carmen"
              "apellidos" => "G&#243;mez Rold&#225;n"
            ]
            5 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "P&#233;rez Mart&#237;nez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251416000225"
        "doi" => "10.1016/j.nefroe.2016.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000225?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515002313?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515002313/v1_201602110042/es/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S0211699515001903"
    "issn" => "02116995"
    "doi" => "10.1016/j.nefro.2015.10.005"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "123"
    "copyright" => "Sociedad Espa&#241;ola de Nefrolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia. 2016;36:42-50"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 11925
      "formatos" => array:3 [
        "EPUB" => 326
        "HTML" => 10566
        "PDF" => 1033
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Hiponatremia&#44; mortalidad y hemodi&#225;lisis&#58; una asociaci&#243;n no explicada"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "42"
          "paginaFinal" => "50"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Hyponatraemia&#44; mortality and haemodialysis&#58; An unexplained association"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figura 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 2833
              "Ancho" => 2594
              "Tamanyo" => 230032
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Curvas de supervivencia &#40;Kaplan-Meier&#41; seg&#250;n el cuartil de la natremia&#46;</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Las curvas de supervivencia muestran el ritmo de fallecimientos seg&#250;n el cuartil &#40;C&#41; de Na en el que estuviese cada paciente a los 6 meses de entrada en las cl&#237;nicas FMC&#46;</p> <p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">El tiempo medio de supervivencia del C1 fue de 3&#44;21 a&#241;os IC &#40;3&#44;10-3&#44;31&#41;&#44; el del C2 de 3&#44;42 a&#241;os IC &#40;3&#44;32-3&#44;51&#41;&#44; el del C3 3&#44;51 a&#241;os IC &#40;3&#44;42-3&#44;60&#41; y por &#250;ltimo el del C4 de 3&#44;53 IC &#40;3&#44;44-3&#44;61&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Rafael P&#233;rez-Garc&#237;a, In&#233;s Palomares, Jos&#233; Ignacio Merello, Rosa Ramos, Francisco Maduell, Manolo Molina, Pedro Aljama, Daniele Marcelli"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "Rafael"
              "apellidos" => "P&#233;rez-Garc&#237;a"
            ]
            1 => array:2 [
              "nombre" => "In&#233;s"
              "apellidos" => "Palomares"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Ignacio"
              "apellidos" => "Merello"
            ]
            3 => array:2 [
              "nombre" => "Rosa"
              "apellidos" => "Ramos"
            ]
            4 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Maduell"
            ]
            5 => array:2 [
              "nombre" => "Manolo"
              "apellidos" => "Molina"
            ]
            6 => array:2 [
              "nombre" => "Pedro"
              "apellidos" => "Aljama"
            ]
            7 => array:2 [
              "nombre" => "Daniele"
              "apellidos" => "Marcelli"
            ]
            8 => array:1 [
              "colaborador" => "en representaci&#243;n del grupo ORD"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2013251416000262"
        "doi" => "10.1016/j.nefroe.2016.02.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2013251416000262?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001903?idApp=UINPBA000064"
    "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515001903/v1_201602110042/es/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Creatine-kinase and dialysis patients&#44; a helpful tool for stratifying cardiovascular risk&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "51"
        "paginaFinal" => "56"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Borja Quiroga, Almudena Vega, Soraya Abad, Maite Villaverde, Javier Reque, Juan Manuel L&#243;pez-G&#243;mez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Borja"
            "apellidos" => "Quiroga"
            "email" => array:1 [
              0 => "borjaqg&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Almudena"
            "apellidos" => "Vega"
          ]
          2 => array:2 [
            "nombre" => "Soraya"
            "apellidos" => "Abad"
          ]
          3 => array:2 [
            "nombre" => "Maite"
            "apellidos" => "Villaverde"
          ]
          4 => array:2 [
            "nombre" => "Javier"
            "apellidos" => "Reque"
          ]
          5 => array:2 [
            "nombre" => "Juan Manuel"
            "apellidos" => "L&#243;pez-G&#243;mez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Nefrolog&#237;a&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Creatincinasa y pacientes en di&#225;lisis&#44; &#191;una herramienta &#250;til para estratificar el riesgo cardiovascular&#63;"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 893
            "Ancho" => 1610
            "Tamanyo" => 84690
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier plot illustrating cardiovascular events and CKMB values&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chronic kidney disease &#40;CKD&#41; is a major cardiovascular risk factor similar to congestive heart failure&#44; and this risk increases with the decline of renal function&#44; being maximum in dialysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Several strategies have been proposed in order to detect those patients at high risk for developing cardiovascular events and for detecting subclinical alterations to be treated&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">3</span></a> Current guidelines recommend measuring cardiac biomarkers&#44; specifically troponins and natriuretic peptides&#44; as they are usually increased in our patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;4</span></a> If possible&#44; ecocardiography should be performed periodically although recommended intervals vary in function of the guideline&#46; Some studies have found a strong association between cardiac biomarkers&#44; ecocardiographic findings and prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">On one hand&#44; serum cardiac biomarkers are increased in virtually all CKD patients especially in dialysis and those who have higher values have poorer prognosis&#46; On the other hand&#44; when these biomarkers are adjusted by ecocardiographic findings &#40;for example&#44; diastolic and systolic dysfunction and left ventricular hypertrophy&#41; they lose their independent prediction value&#44; suggesting their role as observer of cardiac damage&#44; usually subclinically&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5&#44;6</span></a> Most importantly&#44; increased cardiac biomarkers seems to be universal with high sensitivity assays&#44; but those with higher values have a better association to postmortem cardiac damage or with coronary lesions demonstrated by angiography&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">However&#44; and although several authors have proposed different cut-offs for stratifying the cardiovascular risk&#44; lack of agreement has been reached&#44; suggesting that probably those markers must be interpreted as continuous variables&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">One important biomarker has not been widely studied in CKD patients until date&#44; creatine kinase MB isoenzyme &#40;CKMB&#41;&#46; In general population&#44; its sensitivity in acute coronary syndromes is inferior to troponins&#46; However&#44; due to its small half-life&#44; current guidelines recommend its use for monitoring cardiac damage after revascularization as they present a good correlation with re-infarction&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9&#44;10</span></a> Many patients with CKD have been excluded from studies about CKMB due to its difficult interpretation when renal function is impaired&#46; Published series yield controversial data in terms of prevalence of raise serum values and their use in ischemic heart disease&#46; However&#44; it seems to have the same value as prognosis marker in re-infarction in patients with renal impairment&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">11&#44;12</span></a> The aim of the present study was to analyze the prognosis value of CKMB in a cohort of dialysis patients and also its related factors&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 211 patients on hemodialysis in a single center were enrolled in the restrospective study&#46; Stable patients with no cardiovascular events in the 4 weeks before serum determinations were included&#46; During the follow up &#91;39 &#40;19&#8211;56&#41; months&#93;&#44; patients with changes in hemodialysis parameters&#44; transferred to another center or transplanted were censored&#46; Investigations were in accordance with the Declaration of Helsinki&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Baseline characteristics and measurements</span><p id="par0035" class="elsevierStylePara elsevierViewall">Baseline characteristics were recorded&#44; including age&#44; sex&#44; presence of diabetes mellitus&#44; peripheral vascular disease&#44; previous cardiovascular disease &#40;congestive heart failure determined by echocardiography within the three previous months&#44; myocardial infarction&#44; cerebrovascular disease&#41;&#44; dialysis vintage and data regarding the vascular access&#46; Basally&#44; we measured C-reactive protein &#40;CRP&#41;&#44; high sensitivity troponin T &#40;hsTnT&#41;&#44; CK-MB and N-terminal prohormone of brain natriuretic peptide &#40;Nt-proBNP&#41;&#46; All included patients had the same hemodialysis therapy protocol&#58; 4<span class="elsevierStyleHsp" style=""></span>h&#44; three times per week&#46; Routine clinical and biochemical variables were measured by standardized methods on autoanalyzers&#46; CKMB and HsTnT were measured on a Roche&#47;Hitachi Cobas E411 analyzer&#46; Factors related to higher values of CKMB were analyzed&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Echocardiography</span><p id="par0040" class="elsevierStylePara elsevierViewall">Echocardiography was recorded in stable patients who had a less than 6-month one before obtaining the sample and within 24<span class="elsevierStyleHsp" style=""></span>h after the last hemodialysis on the day between mid-week dialysis sessions&#46; Diastolic dysfunction was defined as <span class="elsevierStyleItalic">e</span>&#8242; &#40;early mitral annulus velocity&#41; less than 8<span class="elsevierStyleHsp" style=""></span>cm&#47;s&#44; average <span class="elsevierStyleItalic">E</span> &#40;early mitral flow&#41;&#47;<span class="elsevierStyleItalic">e</span>&#8242; over 8&#44; LAVi &#40;left atrium volume index&#41; over 28<span class="elsevierStyleHsp" style=""></span>mL&#47;m<span class="elsevierStyleSup">2</span> or Ar<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>A &#40;time difference between duration of the pulmonary venous atrial reversal wave and duration of the A wave&#41; over 30<span class="elsevierStyleHsp" style=""></span>ms&#46; Systolic dysfunction in turn was defined as a left ventricle ejection fraction of under 45&#37;&#46; The left ventricular mass index &#40;LVMi&#41; was estimated by Devereux&#39;s formula&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Outcomes</span><p id="par0045" class="elsevierStylePara elsevierViewall">New cardiovascular events &#40;ischemic or hemorrhagic cerebrovascular accident&#44; cardiac event &#91;including myocardial infarction and&#47;or congestive heart failure&#93;&#44; peripheral vascular events and other ischemic events&#41; were recorded during follow-up&#46; We analyzed the predictor value of CKMB for cardiovascular events&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical procedures</span><p id="par0050" class="elsevierStylePara elsevierViewall">Values are expressed as the mean &#40;SD&#41; or median &#40;IQR&#41;&#46; We established linear regression models for evaluating the distribution of the studied variables according to CKMB levels&#46; To assess the diagnosis value of the different cardiac markers we used the receiving operator characteristics &#40;ROC&#41; curve for each one&#46; Correlations between cardiac markers were performed using Pearson test&#46; Multivariate analysis was performed by Cox regression&#46; Variables were analyzed and only those considered confounders were entered in the final Cox regression model&#46; Different models were used&#44; including CKMB for its different values&#44; in order to determine the best cut-off to assess cardiovascular risk&#46; Cardiovascular events were analyzed using Kaplan&#8211;Meier plots&#44; and survival curves were compared using the log-rank test&#46; We used the integrated discrimination improvement &#40;IDI&#41;&#44; as described by Pencina et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> to interpret the incremental value of CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL added to a risk prediction model including age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; NtproBNP and HsTnT&#46; IDI is a measure of improvement in model performance and represents the difference between discrimination slopes of two competing models&#46; We calculated the relative IDI&#44; which expresses the relative increase in separation of events and non-events from the separation achieved in the base model &#40;i&#46;e&#46;&#44; the difference in discrimination slopes is expressed as a proportion of the discrimination slope of the base model&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> All statistical analyses were performed with the SPSS<span class="elsevierStyleSup">&#174;</span> 18&#46;0 statistical package &#40;Chicago&#44; IL&#44; USA&#41;&#46; A <span class="elsevierStyleItalic">p</span>-value &#60;0&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Baseline characteristics and factors associated with increased levels</span><p id="par0055" class="elsevierStylePara elsevierViewall">A total of 211 prevalent hemodialysis patients were included in this study to be followed for 39 &#40;19&#8211;56&#41; months&#46; One hundred and twenty-three patients &#40;58&#46;3&#37;&#41; were male&#44; with a median age of 73 &#40;60&#8211;80&#41;&#46; Baseline characteristic are showed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The median value of CKMB was 1 &#40;1&#8211;2&#41; ng&#47;mL&#44; with the following distribution&#58; 13 patients &#40;6&#46;3&#37;&#41; have basal levels of 0<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 121 &#40;58&#46;5&#41; have 1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 56 &#40;27&#46;1&#37;&#41; have 2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; 13 &#40;6&#46;3&#37;&#41; have 3<span class="elsevierStyleHsp" style=""></span>ng&#47;dL and only 4 &#40;1&#46;9&#41; have 4<span class="elsevierStyleHsp" style=""></span>ng&#47;dL&#46; In <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#44; baseline characteristics are shown in the different strata according to CKMB values&#46; No patients exceeded the normal range of our laboratory &#40;0&#8211;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#46; Univariate analysis revealed that higher levels of CKMB were associated to previous heart disease&#44; diabetes mellitus&#44; peripheral vascular disease and systolic and diastolic dysfunction &#40;data shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Correlation with other cardiac biomarkers</span><p id="par0060" class="elsevierStylePara elsevierViewall">Correlation between cardiac biomarkers showed a positive and significant one between CKMB and NtproBNP &#40;0&#46;163&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;020&#41; and between NtproBNP and HsTnT &#40;0&#46;635&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; No significant correlation was established between CKMB and HsTnT&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Cardiovascular events and predictive value of CKMB</span><p id="par0065" class="elsevierStylePara elsevierViewall">A total of 94 cardiovascular events were recorded during the follow up&#46; Cardiac event was the most common event &#40;79&#46;8&#37;&#41;&#44; followed by peripheral vascular disease &#40;8&#46;5&#37;&#41;&#44; cerebrovascular event &#40;6&#46;4&#37;&#41;&#46; Diabetic patients did not show higher incidence of cardiovascular events in our cohort &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;3&#41;&#44; although they have a trend of higher prevalence of diastolic dysfunction &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;056&#41;&#46; The area under the ROC curve for cardiovascular events was greater for HsTnT &#40;0&#46;723&#41; and Nt-proBNP &#40;0&#46;688&#41; than CKMB &#40;0&#46;587&#41;&#46; CKMB levels were associated to the development of cardiovascular events during follow up &#91;HR 1&#46;46 95&#37; CI &#40;1&#46;15&#8211;1&#46;87&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#93; as well as the other factors shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; In <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; the survival curve shows the association between cardiovascular events and the different CKMB values confirming that higher levels condition worse prognosis &#40;logRank 8&#46;8&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; Multivariate Cox regression model adjusted for several cofounders and variables showed that CKMB levels &#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL independently increased cardiovascular risk in our cohort of hemodialysis patients&#46; A non-significant trend was observed if the CKMB cut-off was &#8805;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">IDI analysis was performed to assess the improvement in risk discrimination of adding CKMB &#40;&#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41; to a cardiovascular event risk prediction model including age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; NtproBNP and HsTnT&#46; This analysis comprised all individuals and used NtproBNP and HsTnT as dichotomous variables&#46; Adding CKMB resulted in 17&#37; improved risk discrimination for cardiovascular events &#40;IDI 0&#46;026 &#91;0&#46;004&#8211;0&#46;053&#93;&#59; relative IDI 9&#46;9&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Our study demonstrates that CK-MB is a useful marker for stratifying cardiovascular risk in dialysis patients&#44; even in normal range values&#46; Importantly for acute situations&#44; hemodialysis patients do not have basally elevated higher levels&#44; so this marker could be useful in the differential diagnosis of chest pain as marker of acute ischemia&#46; Supporting this fact&#44; and different from other cardiac markers&#44; CKMB does not appear to be influenced by the dialysis&#44; so its levels remain stable after and before&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> However&#44; and although CKMB has a short half-life&#44; its levels are correlated to HsTnT and NtproBNP and their values are associated to other cardiovascular risk factors&#46; One study conducted by McCullong et al&#46; that included 817 consecutive patients with chest pain&#44; shown that those with confirmed acute myocardial infarction &#40;AMI&#41; suffer a CKMB rise irrespective of the renal function&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> Curiously&#44; in this study&#44; those patients without final diagnosis of AMI showed significant different basal levels of CKMB between groups &#40;inversely correlated with glomerular filtration and maximum in dialysis patients&#41;&#44; unlike those with final diagnosis of AMI&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The first report regarding the influence of hemodialysis in CKMB levels was published in 1984 by Jaffe et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> In this study that included 88 patients&#44; authors demonstrated normal levels of CKMB for the most part of the studied sample&#46; Although some authors differ in their opinions on this regard&#44; the CHANCE study confirmed not only this situation but also that levels of CK-MB could be influenced by the presence of history of ischemic heart disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">19&#8211;22</span></a> Our results agree with this finding&#44; and with the association to age &#40;we could only demonstrate a trend with this value&#41; and troponins&#46; Cardiovascular risk factors as peripheral vascular disease&#44; diabetes mellitus and Nt-proBNP seem to be associated to CKMB&#44; above all with values &#8805;3<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We assessed the predictive value of CKMB for cardiovascular events&#46; Our data suggests that CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL give a poor cardiovascular prognosis in dialysis patients&#46; Results of CHANCE study agree with our results&#44; showing an increased risk of major cardiovascular events in those patients with CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#44; in a 2-year follow up&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">However&#44; CKMB is not the only marker but the less studied in this regard&#44; although it is cheap and easily applicable in routine clinical&#46; In adjusted multivariate analysis&#44; those patients with HsTnT and NtproBNP over the median and CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL enhanced its cardiovascular risk more than threefold&#44; in comparison to CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL alone&#46; Several studies have found an association between cardiac markers and prognosis&#44; and now we know that this situation reveals a true clinical or subclinical cardiac damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">7&#44;23</span></a> In fact&#44; in our study&#44; CKMB demonstrated an association with previous heart disease and also with systolic and diastolic dysfunction&#46; Previous published data has only been able to remark an association to LVH in patients with renal function impairment&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The present study has some limitations&#46; Firstly&#44; the typical limitations of a retrospective design&#46; Secondly&#44; not all the patients had a echocardiograph image and they were performed by different specialists&#46; This bias was partially avoided by the use of the same criteria for the definitions of each entity &#40;systolic and diastolic dysfunction and LVH&#41;&#46; Thirdly&#44; vascular calcifications were not assessed as recommended in recent guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a> Lastly&#44; the study was performed in one center&#44; and results must be confirmed in bigger sample size&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In conclusion&#44; CKMB is a good marker for stratifying cardiovascular risk in hemodialysis patients even in the normal range of their values&#46; We recommend measuring several cardiac markers&#44; at least two&#44; in order to get better predictive values&#46; As basal levels of CKMB are not elevated in these patients&#44; further studies are required to confirm their value in acute coronary syndromes&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflict of interests</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres604096"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Background and aims"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec618270"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres604097"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Antecedentes y objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec618269"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Baseline characteristics and measurements"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Echocardiography"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Outcomes"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Statistical procedures"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0040"
          "titulo" => "Results"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Baseline characteristics and factors associated with increased levels"
            ]
            1 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Correlation with other cardiac biomarkers"
            ]
            2 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Cardiovascular events and predictive value of CKMB"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of interests"
        ]
        9 => array:2 [
          "identificador" => "xack203332"
          "titulo" => "Acknowledgment"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-12-10"
    "fechaAceptado" => "2015-03-06"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec618270"
          "palabras" => array:4 [
            0 => "Cardiac biomarkers"
            1 => "Cardiovascular"
            2 => "CKMB"
            3 => "Hemodialysis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec618269"
          "palabras" => array:4 [
            0 => "Biomarcadores cardiacos"
            1 => "Cardiovascular"
            2 => "CKMB"
            3 => "Hemodi&#225;lisis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and aims</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hemodialysis patients have an enhanced risk for cardiovascular events&#46; Cardiac biomarkers provide useful information for stratifying their risk&#46; However the prognosis value of creatine kinase MB isoenzyme &#40;CKMB&#41; has not yet been validated in this population&#46; The aim of the present study is to determine the predictable value of CK-MB in hemodialysis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cohort of 211 hemodialysis patients &#40;58&#46;3&#37; male&#44; median age 73 &#40;60&#8211;80&#41; years&#41; were followed for 39 &#40;19&#8211;56&#41; months&#46; Cardiac biomarkers including CKMB were recorded at baseline&#46; Factors associated to CKMB and prognosis value of this biomarker was studied&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The median value of CKMB was 1 &#40;1&#8211;2&#41; ng&#47;mL with no patient exceeding normal laboratory values&#46; Previous heart disease&#44; diabetes mellitus&#44; peripheral vascular disease and systolic and diastolic dysfunction were associated with higher levels of CKMB&#46; Ninety-four patients &#40;44&#46;5&#37;&#41; cardiovascular events were recorded&#46; CKMB levels &#8805;2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL was independently associated to cardiovascular events during the follow up after adjusting&#46; Adding CKMB to a model including several variables for predicting cardiovascular events&#44; resulted in 17&#37; improvement in risk discrimination &#40;IDI&#41; with a relative IDI of 9&#46;9&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">CKMB is a good marker for stratifying cardiovascular risk in hemodialysis patients and adds prognosis information to other well known independent predictors for cardiovascular events&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background and aims"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los pacientes en hemodi&#225;lisis presentan un riesgo cardiovascular elevado&#46; Los biomarcadores cardiacos otorgan informaci&#243;n &#250;til para estratificar dicho riesgo cardiovascular&#46; Sin embargo&#44; el valor pron&#243;stico de la isoenzima MB de la creatincinasa &#40;CKMB&#41; no ha sido a&#250;n validado en esta poblaci&#243;n&#46; El objetivo del presente trabajo es evaluar el valor predictivo de CKMB en una poblaci&#243;n en hemodi&#225;lisis&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Una cohorte de 211 pacientes en hemodi&#225;lisis &#40;58&#44;3&#37; varones&#44; con una edad media de 73 &#91;60&#8211;80&#93; a&#241;os&#41; fueron seguidos durante 39 &#40;19&#8211;56&#41; meses&#46; Se recogieron basalmente los valores de diferentes biomarcadores cardiacos incluyendo CKMB&#46; Se evaluaron los factores asociados a niveles m&#225;s elevados de CKMB&#44; as&#237; como su valor predictivo independiente&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La mediana de CKMB fue de 1 &#40;1&#8211;2&#41; ng&#47;mL&#46; Todos los pacientes presentaron valores dentro de los establecidos de referencia en la poblaci&#243;n normal&#46; Los antecedentes de cardiopat&#237;a&#44; diabetes mellitus&#44; enfermedad perif&#233;rica y la disfunci&#243;n diast&#243;lica y sist&#243;lica se asociaron a niveles m&#225;s elevados de CKMB&#46; Un total de 94 pacientes &#40;44&#44;5&#37;&#41; presentaron un evento cardiovascular&#46; Los niveles de CKMB<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>ng&#47;mL se asociaron de manera independiente a presentar eventos cardiovasculares durante el seguimiento tras el ajuste para diferentes factores&#46; La adici&#243;n de CKMB a un modelo predictor con diferentes factores gener&#243; una mejor&#237;a del 17&#37; en la estimaci&#243;n de la probabilidad de forma lineal &#40;IDI&#41; con un IDI relativo del 9&#44;9&#37; &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">CKMB es un buen marcador para estratificar el riesgo cardiovascular en los pacientes de hemodi&#225;lisis y a&#241;ade informaci&#243;n en cuanto al pron&#243;stico cuando se combina con otros predictores de eventos cardiovasculares&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 893
            "Ancho" => 1610
            "Tamanyo" => 84690
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier plot illustrating cardiovascular events and CKMB values&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;60-80&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex male&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123 &#40;58&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">History of heart disease&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;42&#46;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;32&#46;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64 &#40;30&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous echocardiogram&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">166 &#40;78&#46;7&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Left ventricular hypertrophy&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;63&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Systolic dysfunction&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;14&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">- Diastolic dysfunction&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60 &#40;36&#46;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous dialysis vintage &#40;months&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;43-128&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Vascular access</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- Autologous</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- PTFE</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">- Permanent catheter</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">116 &#40;55&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>65 &#40;31&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>30 &#40;14&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;35-90&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#40;ng&#47;mL&#41;</span><span class="elsevierStyleBold">- 0 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 1 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 2 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 3 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span><span class="elsevierStyleBold">- 4 ng&#47;mL</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">&#44;n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1-2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>13 &#40;6&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>121 &#40;58&#46;5&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>56 &#40;27&#46;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>13 &#40;6&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>4 &#40;1&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4994 &#40;2237-15036&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;0 &#40;4&#46;0-15&#46;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989330.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mean &#40;standart deviation&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Median &#40;interquartile range&#41;&#46; High sentivity troponin T &#40;hsTnT&#41;&#44; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 0 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;13&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 1 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;121&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#61; 2 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;56&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">CKMB &#8805; 3 ng&#47;mL</span><span class="elsevierStyleItalic">&#40;n&#61;17&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P for trend</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;62-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">75 &#40;56-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73 &#40;63-78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;70-64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex male &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous heart disease &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes mellitus &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease&#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Left ventricular hypertrophy &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;181&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Systolic dysfunction &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diastolic dysfunction &#40;&#37;&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous dialysis vintage &#40;months&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">107 &#40;38-132&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82 &#40;46-128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85 &#40;31-148&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62 &#40;40-122&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#40;ng&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71 &#40;39-88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;30-74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67 &#40;42-128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89 &#40;44-144&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;ng&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6814 &#40;3894-12466&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4112 &#40;2159-14244&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7293 &#40;2506-17008&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10524 &#40;4265-20146&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;L&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;0 &#40;6&#46;5-27&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;0 &#40;3&#46;0-14&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;0 &#40;4&#46;0-12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;0 &#40;6&#46;0-22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989331.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Median &#40;interquartile range&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Percentage over the patients with a previous echocardiogram &#40;166&#41;&#46; Abbrev&#46;&#58; High sentivity troponin T &#40;hsTnT&#41;&#44; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span></p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Descriptive of baseline characteristics according to CKMB values&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; HR &#40;95&#37; CI&#41; &#61; Hazard ratio &#40;95&#37; Confidence interval&#41;&#46; &#40;F&#47;M&#41;&#61;&#40;female&#47;male&#41;&#46; <span class="elsevierStyleItalic">Creatinekinase-MB&#40;CK</span>-<span class="elsevierStyleItalic">MB</span>&#41;&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide &#40;</span>NT-proBNP&#41;&#44;High sentivity troponin T &#40;hsTnT&#41;&#44; C- reactive protein &#40;CRP&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;02 &#40;1&#46;01-1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Sex &#40;male&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;11 &#40;0&#46;73-1&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;619&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Previous Heart Disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;99 &#40;3&#46;16-7&#46;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diabetes Mellitus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;23 &#40;0&#46;81-1&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Peripheral vascular disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;53 &#40;1&#46;01-2&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Dialysis Vintage &#40;per month&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;00 &#40;0&#46;99-1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;825&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Vascular access &#40;autologus fistualae&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup"><span class="elsevierStyleBold">&#42;</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;96 &#40;0&#46;64-1&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;860&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Left ventricular hypertrophy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;64 &#40;0&#46;94-2&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;080&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Systolic dysfunction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;72 &#40;1&#46;52-4&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Diastolic dysfunction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;59 &#40;1&#46;52-4&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CK-MB &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;46 &#40;1&#46;15-1&#46;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">HsTnT &#8805; 56 ng&#47;L &#40;ng&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;52 &#40;1&#46;47-4&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Nt-proBNP &#40;mcg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;01 &#40;1&#46;01-1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CRP &#40;mg&#47;dL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;01 &#40;0&#46;96-1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;578&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989332.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Autologous vascular access has been codified as 0 and non-autologous as 1&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Factors associated with cardiovascular events during follow up &#40;unadjusted Cox regression&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#61; 0 &#40;ng&#47;mL&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ref</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ref</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#8805; 1 ng&#47;mL</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span></a><span class="elsevierStyleBold">- CKMB &#8805; 1 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;20 &#40;0&#46;88-5&#46;51&#41;2&#46;84 &#40;1&#46;79-4&#46;53&#41;1&#46;98 &#40;1&#46;23-3&#46;17&#41;2&#46;71 &#40;1&#46;74-4&#46;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;092&#60;0&#46;0010&#46;005&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">CKMB &#8805; 2 &#40;ng&#47;mL&#41;</span><a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a><span class="elsevierStyleBold">- CKMB &#8805; 2 ng&#47;mL &#42; NtproBNP &#8805; 4994 ng&#47;L &#42; HsTnT &#8805; 56 ng&#47;L</span><a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;63 &#40;1&#46;06-2&#46;53&#41;3&#46;01 &#40;1&#46;90-4&#46;81&#41;1&#46;82 &#40;1&#46;11-2&#46;99&#41;3&#46;24 &#40;1&#46;92-5&#46;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;027&#60;0&#46;0010&#46;016&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab989333.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Cox regression model adjusted for age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#44; N-terminal prohormone of brain <span class="elsevierStyleItalic">natriureticpeptide</span> and high sentivity troponin T&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Cox regression model adjusted for age&#44; sex&#44; previous heart disease&#44; peripheral vascular disease&#44; diabetes mellitus&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Predictor value of the different values of CK-MB for cardiovascular events during follow up &#40;adjusted Cox regression&#41; alone and in combination with the other cardiac biomarkers&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T predicts mortality in patients with end-stage renal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Dierkes"
                            1 => "U&#46; Domrose"
                            2 => "S&#46; Westphal"
                            3 => "A&#46; Ambrosch"
                            4 => "H&#46;P&#46; Bosselmann"
                            5 => "K&#46;H&#46; Neumann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2000"
                        "volumen" => "102"
                        "paginaInicial" => "1964"
                        "paginaFinal" => "1969"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11034946"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606692908"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence-based cardiology in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Allon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1681/ASN.2013060632"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Nephrol"
                        "fecha" => "2013"
                        "volumen" => "24"
                        "paginaInicial" => "1934"
                        "paginaFinal" => "1943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24136920"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic utility of cardiac biomarkers in dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;Y&#46; Wang"
                            1 => "C&#46; Wai-Kei Lam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-139X.2012.01099.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2012"
                        "volumen" => "25"
                        "paginaInicial" => "388"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22748194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponins and chronic kidney disease&#44; what do we know&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Quiroga"
                            1 => "D&#46; Arroyo"
                            2 => "M&#46; Goicoechea"
                            3 => "S&#46; Garcia de Vinuesa"
                            4 => "J&#46; Lu&#241;o"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Cardiovasc Res"
                        "fecha" => "2013"
                        "volumen" => "2"
                        "paginaInicial" => "5"
                        "itemHostRev" => array:3 [
                          "pii" => "S014067361160874X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diastolic dysfunction and high levels of new cardiac biomarkers as risk factors for cardiovascular events and mortality in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Quiroga"
                            1 => "M&#46; Villaverde"
                            2 => "S&#46; Abad"
                            3 => "A&#46; Vega"
                            4 => "J&#46; Reque"
                            5 => "J&#46;M&#46; L&#243;pez-G&#243;mez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000354080"
                      "Revista" => array:7 [
                        "tituloSerie" => "Blood Purif"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "98"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24051551"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674909015383"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of echocardiography in observational clinical trials&#58; the EURECA-m registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Sicari"
                            1 => "L&#46; Gargani"
                            2 => "A&#46; Wiecek"
                            3 => "A&#46; Covic"
                            4 => "D&#46; Goldsmith"
                            5 => "G&#46; Suleymanlar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfs399"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2013"
                        "volumen" => "28"
                        "paginaInicial" => "19"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23048175"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673602116795"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T in hemodialyzed patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Ooi"
                            1 => "A&#46;A&#46; House"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1998"
                        "volumen" => "44"
                        "paginaInicial" => "1410"
                        "paginaFinal" => "1416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9665417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac troponin T and C-reactive protein for predicting prognosis&#44; coronary atherosclerosis&#44; and cardiomyopathy in patients undergoing long-term hemodialysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; deFilippi"
                            1 => "S&#46; Wasserman"
                            2 => "S&#46; Rosanio"
                            3 => "E&#46; Tiblier"
                            4 => "H&#46; Sperger"
                            5 => "M&#46; Tocchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.290.3.353"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2003"
                        "volumen" => "290"
                        "paginaInicial" => "353"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12865376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2012 ACCF&#47;AHA focused update incorporated into the ACCF&#47;AHA 2007 guidelines for the management of patients with unstable angina&#47;non-ST-elevation myocardial infarction&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Anderson"
                            1 => "C&#46;D&#46; Adams"
                            2 => "E&#46;M&#46; Antman"
                            3 => "C&#46;R&#46; Bridges"
                            4 => "R&#46;M&#46; Califf"
                            5 => "D&#46;E&#46; Casey Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2013.01.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2012"
                        "volumen" => "61"
                        "paginaInicial" => "e179"
                        "paginaFinal" => "e347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23639841"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ACCF&#47;AHA guideline for the management of ST-elevation myocardial infarction&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;T&#46; O&#8217;Gara"
                            1 => "F&#46;G&#46; Kushner"
                            2 => "D&#46;D&#46; Ascheim"
                            3 => "D&#46;E&#46; Casey Jr&#46;"
                            4 => "M&#46;K&#46; Chung"
                            5 => "J&#46;A&#46; de Lemos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIR.0b013e3182742cf6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2013"
                        "volumen" => "127"
                        "paginaInicial" => "e362"
                        "paginaFinal" => "e425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23247304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic value of cardiac markers in ESRD&#58; Chronic Hemodialysis and New Cardiac Markers Evaluation &#40;CHANCE&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Iliou"
                            1 => "C&#46; Fumeron"
                            2 => "M&#46;O&#46; Benoit"
                            3 => "P&#46; Tuppin"
                            4 => "V&#46;M&#46; Calonge"
                            5 => "N&#46; Moatti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "paginaInicial" => "513"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12955679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparison of cardiac biomarkers positivities in hemodialysis patients without acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Korkmaz"
                            1 => "G&#46; Sasak"
                            2 => "A&#46; Celik"
                            3 => "E&#46; Kurto&#287;lu"
                            4 => "M&#46; G&#252;rger"
                            5 => "K&#46;B&#46; Bursal&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.585264"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "578"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular hypertrophy and function in high&#44; normal&#44; and low-renin forms of essential hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;B&#46; Devereux"
                            1 => "D&#46;D&#46; Savage"
                            2 => "J&#46;I&#46; Drayer"
                            3 => "J&#46;H&#46; Laragh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1982"
                        "volumen" => "4"
                        "paginaInicial" => "524"
                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6218079"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;J&#46; Pencina"
                            1 => "R&#46;B&#46; D&#8217;Agostino Sr&#46;"
                            2 => "E&#46;W&#46; Steyerberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/sim.4085"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stat Med"
                        "fecha" => "2011"
                        "volumen" => "30"
                        "paginaInicial" => "11"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21204120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpreting incremental value of markers added to risk prediction models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;J&#46; Pencina"
                            1 => "R&#46;B&#46; D&#8217;Agostino"
                            2 => "K&#46;M&#46; Pencina"
                            3 => "A&#46;C&#46; Janssens"
                            4 => "P&#46; Greenland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kws207"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2012"
                        "volumen" => "176"
                        "paginaInicial" => "473"
                        "paginaFinal" => "481"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22875755"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S014067360861452X"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of hemodialysis on cardiac enzyme levels and echocardiographic parameters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ingec"
                            1 => "E&#46;G&#46; Oguz"
                            2 => "T&#46; Yildirim"
                            3 => "T&#46; Ulas"
                            4 => "M&#46; Horoz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5301/ijao.5000333"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Artif Organs"
                        "fecha" => "2014"
                        "volumen" => "37"
                        "paginaInicial" => "513"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24970560"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674910002897"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of multiple cardiac biomarkers measured in the emergency department in patients with chronic kidney disease and chest pain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;A&#46; McCullough"
                            1 => "R&#46;M&#46; Nowak"
                            2 => "C&#46; Foreback"
                            3 => "G&#46; Tokarski"
                            4 => "M&#46;C&#46; Tomlanovich"
                            5 => "N&#46;E&#46; Khoury"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acad Emerg Med"
                        "fecha" => "2002"
                        "volumen" => "9"
                        "paginaInicial" => "1389"
                        "paginaFinal" => "1396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unmasking artifactual increases in creatine kinase isoenzymes in patients with renal failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;S&#46; Jaffe"
                            1 => "C&#46; Ritter"
                            2 => "V&#46; Meltzer"
                            3 => "H&#46; Harter"
                            4 => "R&#46; Roberts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lab Clin Med"
                        "fecha" => "1984"
                        "volumen" => "104"
                        "paginaInicial" => "193"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6747438"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serum enzyme levels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;D&#46; Vaziri"
                            1 => "D&#46; Kayichian"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "titulo" => "Handbook of dialysis"
                        "paginaInicial" => "482"
                        "paginaFinal" => "489"
                        "edicion" => "4th ed&#46;"
                        "serieFecha" => "2007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The comparison of cardiac biomarkers positivities in hemodialysis patients without acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Korkmaz"
                            1 => "G&#46; Sa&#351;ak"
                            2 => "A&#46; Celik"
                            3 => "E&#46; Kurto&#287;lu"
                            4 => "M&#46; G&#252;rger"
                            5 => "K&#46;B&#46; Bursal&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/0886022X.2011.585264"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ren Fail"
                        "fecha" => "2011"
                        "volumen" => "33"
                        "paginaInicial" => "578"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21663388"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674912005234"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do cardiac troponins provide prognostic insight in hemodialysis patients&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;B&#46; Choy"
                            1 => "P&#46;W&#46; Armstrong"
                            2 => "R&#46;A&#46; Ulan"
                            3 => "P&#46;M&#46; Campbell"
                            4 => "S&#46; Gourishankar"
                            5 => "C&#46;I&#46; Prosser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Cardiol"
                        "fecha" => "2003"
                        "volumen" => "19"
                        "paginaInicial" => "907"
                        "paginaFinal" => "911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12876611"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients&#58; Chronic Haemodialysis and New Cardiac Markers Evaluation &#40;CHANCE&#41; study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Iliou"
                            1 => "C&#46; Fumeron"
                            2 => "M&#46;O&#46; Benoit"
                            3 => "P&#46; Tuppin"
                            4 => "C&#46;L&#46; Courvoisier"
                            5 => "V&#46;M&#46; Calonge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "1452"
                        "paginaFinal" => "1458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11427640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac markers in different degrees of chronic kidney disease&#58; influence of inflammation and previous heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Quiroga"
                            1 => "M&#46; Goicoechea"
                            2 => "S&#46; Garc&#237;a de Vinuesa"
                            3 => "E&#46; Verde"
                            4 => "U&#46; Verdalles"
                            5 => "C&#46; Yuste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2012"
                        "volumen" => "139"
                        "paginaInicial" => "98"
                        "paginaFinal" => "102"
                        "itemHostRev" => array:3 [
                          "pii" => "S0091674909003479"
                          "estado" => "S300"
                          "issn" => "00916749"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vascular calcification in chronic kidney disease&#58; are biomarkers useful for probing the pathobiology and the health risks of this process in the clinical scenario&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Liabeuf"
                            1 => "H&#46; Okazaki"
                            2 => "L&#46; Desjardins"
                            3 => "D&#46; Fliser"
                            4 => "D&#46; Goldsmith"
                            5 => "A&#46; Covic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gft368"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "1275"
                        "paginaFinal" => "1284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24009287"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack203332"
        "titulo" => "Acknowledgment"
        "texto" => "<p id="par0110" class="elsevierStylePara elsevierViewall">We would like to thank Vilma E&#46; Pacheco for proofreading the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/02116995/0000003600000001/v1_201602110042/S0211699515001897/v1_201602110042/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "42448"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02116995/0000003600000001/v1_201602110042/S0211699515001897/v1_201602110042/en/main.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0211699515001897?idApp=UINPBA000064"
]
Información del artículo
ISSN: 02116995
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 8 5 13
2024 Octubre 53 30 83
2024 Septiembre 73 22 95
2024 Agosto 77 65 142
2024 Julio 58 31 89
2024 Junio 69 36 105
2024 Mayo 56 35 91
2024 Abril 68 51 119
2024 Marzo 46 28 74
2024 Febrero 38 32 70
2024 Enero 45 29 74
2023 Diciembre 38 20 58
2023 Noviembre 72 38 110
2023 Octubre 83 39 122
2023 Septiembre 55 25 80
2023 Agosto 58 33 91
2023 Julio 64 32 96
2023 Junio 103 18 121
2023 Mayo 102 27 129
2023 Abril 80 11 91
2023 Marzo 92 26 118
2023 Febrero 84 18 102
2023 Enero 41 34 75
2022 Diciembre 73 27 100
2022 Noviembre 69 53 122
2022 Octubre 73 43 116
2022 Septiembre 56 33 89
2022 Agosto 67 55 122
2022 Julio 38 59 97
2022 Junio 62 46 108
2022 Mayo 65 47 112
2022 Abril 59 60 119
2022 Marzo 70 56 126
2022 Febrero 61 44 105
2022 Enero 47 51 98
2021 Diciembre 72 49 121
2021 Noviembre 63 48 111
2021 Octubre 76 46 122
2021 Septiembre 59 49 108
2021 Agosto 115 30 145
2021 Julio 49 42 91
2021 Junio 54 32 86
2021 Mayo 63 37 100
2021 Abril 96 58 154
2021 Marzo 79 54 133
2021 Febrero 75 11 86
2021 Enero 58 18 76
2020 Diciembre 59 19 78
2020 Noviembre 58 16 74
2020 Octubre 28 30 58
2020 Septiembre 49 14 63
2020 Agosto 60 15 75
2020 Julio 49 14 63
2020 Junio 33 28 61
2020 Mayo 77 28 105
2020 Abril 54 23 77
2020 Marzo 45 22 67
2020 Febrero 64 20 84
2020 Enero 69 48 117
2019 Diciembre 53 36 89
2019 Noviembre 53 31 84
2019 Octubre 26 25 51
2019 Septiembre 33 23 56
2019 Agosto 30 23 53
2019 Julio 15 21 36
2019 Junio 32 30 62
2019 Mayo 38 20 58
2019 Abril 88 38 126
2019 Marzo 51 31 82
2019 Febrero 32 18 50
2019 Enero 20 27 47
2018 Diciembre 229 40 269
2018 Noviembre 472 25 497
2018 Octubre 366 31 397
2018 Septiembre 97 19 116
2018 Agosto 66 15 81
2018 Julio 50 16 66
2018 Junio 62 19 81
2018 Mayo 118 8 126
2018 Abril 132 20 152
2018 Marzo 147 15 162
2018 Febrero 141 13 154
2018 Enero 86 10 96
2017 Diciembre 123 9 132
2017 Noviembre 73 12 85
2017 Octubre 62 9 71
2017 Septiembre 41 11 52
2017 Agosto 42 11 53
2017 Julio 62 14 76
2017 Junio 64 15 79
2017 Mayo 77 10 87
2017 Abril 58 13 71
2017 Marzo 43 17 60
2017 Febrero 38 17 55
2017 Enero 17 15 32
2016 Diciembre 73 7 80
2016 Noviembre 84 23 107
2016 Octubre 119 15 134
2016 Septiembre 128 11 139
2016 Agosto 149 5 154
2016 Julio 217 12 229
2016 Junio 115 0 115
2016 Mayo 202 0 202
2016 Abril 165 0 165
2016 Marzo 179 0 179
2016 Febrero 195 0 195
2016 Enero 59 0 59
2015 Diciembre 21 0 21
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Nefrología
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?