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Letter to the Editor
Reply to the Letter to the Editor: Is there any association between overhydration and inflammation in dialysis patients?
Respuesta a la carta al Editor: ¿Hay alguna asociación entre sobrehidratación e inflamación en los pacientes en diálisis?
Almudena Vega
Autor para correspondencia
vega.almudena@gmail.com

Corresponding author: Tel.: +34 91 5868047; fax: +34 91 5868047.
, Soraya Abad
Servicio de Nefrología. Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo, 46, CP: 28007, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We would like to thank Dr&#46; Agilli for the comments and suggestions&#59; we consider that they are interesting and in our opinion they improve the quality of our manuscript &#8220;Study of overhydration in dialysis patients and its association with inflammation&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In our study&#44; we have analyzed stable patients &#40;as explained in the Methods&#41; but it could have been explained with more detail&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Patient included had stable blood parameters to rule out other confounding factors&#46; We did not include patients with active malignancy&#44; major depression&#44; anorexia nervosa&#44; bulimia nervosa or any kind of inflammatory disorders&#46; We did not take into consideration if patients had Helicobacter pylori infection or thyroid diseases&#44; so we have to admit that this omission fact as a limitation in our study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We do not usually prescribe dietary supplements such as vitamin C&#44; vitamin A&#44; zinc or omega-3 fatty acids&#59; therefore in this study&#44; patients were not receiving this type of treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As we had excluded patients with inflammatory disorders&#44; we cannot find a reason why patients had to receive corticosteroids agents&#46; Progestational agents &#40;Megestrol&#41; are given to patients with anorexia to stimulate appetite in&#46; In our study those patients were excluded&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The use of alcohol was not recorded&#44; this is another limitation&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Blood parameters were taken before their dialysis sessions and after bioimpedance&#46; Patients had to remain supine position for at least 10<span class="elsevierStyleHsp" style=""></span>min to perform bioimpedance&#46; It is unlikely that patients are bedridden since they come from their home three times per week for dialysis&#46; Patients admitted at the hospital were not included in the study&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Serum transthyretin concentration is not necessary affected by hydration status&#46; However&#44; as shown in our manuscript&#44; patients with inflammation are overhydrated&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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