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"tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "200" "paginaFinal" => "201" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mehmet Agilli, Tolga Dogan, Mustafa Ilker Inan, Gonca Fidan" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Mehmet" "apellidos" => "Agilli" "email" => array:1 [ 0 => "mehmetagilli@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Tolga" "apellidos" => "Dogan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mustafa Ilker" "apellidos" => "Inan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Gonca" "apellidos" => "Fidan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Biochemistry, Agri Military Hospital, Agri, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Chest Diseases, Girne Military Hospital, Girne, Cyprus" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Infectious Diseases and Clinical Microbiology, Agri Military Hospital, Agri, Turkey" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Hay alguna relación entre la sobrehidratación y la inflamación en pacientes en diálisis?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In a recent issue of <span class="elsevierStyleItalic">Nefrologia</span>, we read the paper of Dr Vega and colleagues entitled “Study on overhydration in dialysis patients and its association with inflammation”.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> We thank for their valuable research evaluating hydration status and body composition in patients on haemodialysis and its relation to inflammation. They found an association between hydration status and low prealbumin (transthyretin) levels. We want to make some comments on transthyretin (TTR) which was assessed in their study.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Serum TTR has been reported to be a reliable outcome predictor in patients with kidney disease.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Previous studies suggested that several factors can affect serum TTR levels. Disorders such as anorexia nervosa, bulimia nervosa, rheumatoid arthritis, ankylosing spondylitis, major depression, trauma, malignancy, protein losing enteropathy, Kawasaki disease, liver diseases, <span class="elsevierStyleItalic">Helicobacter pylori</span> infection and thyroid diseases were shown to alter serum TTR levels.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,4</span></a> Vega et al. did not mention these contributing diseases in their paper.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Several drugs such as anabolic steroids, corticosteroids, progestational agents, estrogens, antithyroid drugs and nonsteroidal antinflammatory drugs can alter serum TTR levels.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a> Also, dietary supplements such as vitamin A, vitamin C, zinc and omega-3 fatty acids can alter these levels.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7,8</span></a> In this respect, the authors should define whether the participants use any of these drugs and dietary supplements. In addition, alcohol usage is another confounder that should be described whether the participants use.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Lastly, we think that body position is essential to state while taking blood specimen. It is recommended that blood specimens for measuring plasma proteins be taken after nearly 15–20<span class="elsevierStyleHsp" style=""></span>min in the sitting position.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Otherwise, concentrations should be evaluated with consideration of position. Lower levels are to be expected in bedridden patients.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Therefore, interpretation of results with its current form seems problematic.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Mears and many researchers suggested that serum TTR concentration was not affected by hydration status.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> In this respect, authors’ claim as association between hydration status and low TTR levels seems suspicious irrespective of taking into account above contributing factors. Clarifying these concerns will provide clearer picture to the readers.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study on overhydration in dialysis patients and its association with inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 5 | 11 | 16 |
2024 Octubre | 41 | 49 | 90 |
2024 Septiembre | 42 | 30 | 72 |
2024 Agosto | 56 | 62 | 118 |
2024 Julio | 36 | 25 | 61 |
2024 Junio | 53 | 37 | 90 |
2024 Mayo | 50 | 37 | 87 |
2024 Abril | 45 | 32 | 77 |
2024 Marzo | 35 | 32 | 67 |
2024 Febrero | 32 | 34 | 66 |
2024 Enero | 43 | 27 | 70 |
2023 Diciembre | 42 | 26 | 68 |
2023 Noviembre | 53 | 31 | 84 |
2023 Octubre | 62 | 26 | 88 |
2023 Septiembre | 64 | 25 | 89 |
2023 Agosto | 62 | 24 | 86 |
2023 Julio | 35 | 28 | 63 |
2023 Junio | 55 | 19 | 74 |
2023 Mayo | 71 | 31 | 102 |
2023 Abril | 46 | 17 | 63 |
2023 Marzo | 48 | 22 | 70 |
2023 Febrero | 37 | 29 | 66 |
2023 Enero | 30 | 33 | 63 |
2022 Diciembre | 54 | 32 | 86 |
2022 Noviembre | 61 | 34 | 95 |
2022 Octubre | 38 | 54 | 92 |
2022 Septiembre | 44 | 35 | 79 |
2022 Agosto | 51 | 44 | 95 |
2022 Julio | 31 | 54 | 85 |
2022 Junio | 36 | 37 | 73 |
2022 Mayo | 38 | 40 | 78 |
2022 Abril | 38 | 60 | 98 |
2022 Marzo | 38 | 62 | 100 |
2022 Febrero | 33 | 36 | 69 |
2022 Enero | 34 | 42 | 76 |
2021 Diciembre | 41 | 48 | 89 |
2021 Noviembre | 34 | 40 | 74 |
2021 Octubre | 28 | 54 | 82 |
2021 Septiembre | 33 | 48 | 81 |
2021 Agosto | 40 | 45 | 85 |
2021 Julio | 38 | 37 | 75 |
2021 Junio | 27 | 36 | 63 |
2021 Mayo | 40 | 36 | 76 |
2021 Abril | 60 | 52 | 112 |
2021 Marzo | 39 | 37 | 76 |
2021 Febrero | 35 | 19 | 54 |
2021 Enero | 31 | 23 | 54 |
2020 Diciembre | 26 | 16 | 42 |
2020 Noviembre | 39 | 20 | 59 |
2020 Octubre | 31 | 31 | 62 |
2020 Septiembre | 25 | 19 | 44 |
2020 Agosto | 38 | 16 | 54 |
2020 Julio | 24 | 18 | 42 |
2020 Junio | 21 | 25 | 46 |
2020 Mayo | 35 | 20 | 55 |
2020 Abril | 31 | 26 | 57 |
2020 Marzo | 30 | 16 | 46 |
2020 Febrero | 37 | 25 | 62 |
2020 Enero | 34 | 28 | 62 |
2019 Diciembre | 35 | 25 | 60 |
2019 Noviembre | 28 | 19 | 47 |
2019 Octubre | 15 | 12 | 27 |
2019 Septiembre | 27 | 17 | 44 |
2019 Agosto | 19 | 22 | 41 |
2019 Julio | 26 | 21 | 47 |
2019 Junio | 25 | 17 | 42 |
2019 Mayo | 21 | 24 | 45 |
2019 Abril | 42 | 35 | 77 |
2019 Marzo | 31 | 23 | 54 |
2019 Febrero | 24 | 19 | 43 |
2019 Enero | 26 | 23 | 49 |
2018 Diciembre | 144 | 41 | 185 |
2018 Noviembre | 309 | 18 | 327 |
2018 Octubre | 267 | 15 | 282 |
2018 Septiembre | 108 | 13 | 121 |
2018 Agosto | 65 | 12 | 77 |
2018 Julio | 66 | 9 | 75 |
2018 Junio | 74 | 11 | 85 |
2018 Mayo | 82 | 12 | 94 |
2018 Abril | 97 | 15 | 112 |
2018 Marzo | 62 | 11 | 73 |
2018 Febrero | 103 | 12 | 115 |
2018 Enero | 43 | 8 | 51 |
2017 Diciembre | 92 | 7 | 99 |
2017 Noviembre | 42 | 7 | 49 |
2017 Octubre | 39 | 8 | 47 |
2017 Septiembre | 44 | 27 | 71 |
2017 Agosto | 45 | 4 | 49 |
2017 Julio | 58 | 7 | 65 |
2017 Junio | 72 | 12 | 84 |
2017 Mayo | 56 | 14 | 70 |
2017 Abril | 39 | 15 | 54 |
2017 Marzo | 33 | 7 | 40 |
2017 Febrero | 24 | 3 | 27 |
2017 Enero | 25 | 9 | 34 |
2016 Diciembre | 29 | 7 | 36 |
2016 Noviembre | 51 | 14 | 65 |
2016 Octubre | 73 | 14 | 87 |
2016 Septiembre | 105 | 8 | 113 |
2016 Agosto | 124 | 4 | 128 |
2016 Julio | 160 | 16 | 176 |
2016 Junio | 110 | 0 | 110 |
2016 Mayo | 190 | 0 | 190 |
2016 Abril | 159 | 0 | 159 |
2016 Marzo | 87 | 0 | 87 |
2016 Febrero | 42 | 0 | 42 |
2016 Enero | 38 | 0 | 38 |
2015 Diciembre | 32 | 0 | 32 |
2015 Noviembre | 29 | 0 | 29 |
2015 Octubre | 33 | 0 | 33 |
2015 Septiembre | 20 | 0 | 20 |
2015 Agosto | 13 | 0 | 13 |