Hypertension in the African American population: A succinct look at its epidemiology, pathogenesis, and therapy
Hipertensión en la población afroamericana: breve examen de su epidemiología, patogénesis y terapia
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Map shows the mortality rate due to diabetes mellitus (deaths/100,000 individuals per year, INEC [Instituto Nacional de Estadísticas y Censos - National Institute of Statistics and Census of Ecuador] 2011). This figure is part of a figure originally published by Neira-Mosquera et al.6, with minor modifications (authorised reproduction)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Katherine Carranza, Dolores Veron, Alicia Cercado, Noemi Bautista, Wilson Pozo, Alda Tufro, Delma Veron" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Katherine" "apellidos" => "Carranza" ] 1 => array:2 [ "nombre" => "Dolores" "apellidos" => "Veron" ] 2 => array:2 [ "nombre" => "Alicia" "apellidos" => "Cercado" ] 3 => array:2 [ "nombre" => "Noemi" "apellidos" => "Bautista" ] 4 => array:2 [ "nombre" => "Wilson" "apellidos" => "Pozo" ] 5 => array:2 [ "nombre" => "Alda" "apellidos" => "Tufro" ] 6 => array:2 [ "nombre" => "Delma" "apellidos" => "Veron" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251415119105?idApp=UINPBA000064" "url" => "/20132514/0000003500000002/v0_201504231604/X2013251415119105/v0_201504231605/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Hypertension in the African American population: A succinct look at its epidemiology, pathogenesis, and therapy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "139" "paginaFinal" => "145" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Luis M Ortega, Emad Sedki, Ali Nayer" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Luis M" "apellidos" => "Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Emad" "apellidos" => "Sedki" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Ali" "apellidos" => "Nayer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Division of Nephrology and Hypertension. Allegheny General Hospital/Temple University School of Medicine. Pittsburgh, Pennsylvania (Estados Unidos)" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Division of Nephrology and Hypertension. University of Miami Miller School of Medicine. Miami, Florida (Estados Unidos)" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hipertensión en la población afroamericana: breve examen de su epidemiología, patogénesis y terapia" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "498v35n02-90411918fig3.jpg" "Alto" => 1200 "Ancho" => 2037 "Tamanyo" => 210277 ] ] "descripcion" => array:1 [ "en" => "– Treatment of hypertension in African Americans vs Whites. a Albumin:creatinine >200 mg/g, eGFR <60 ml min 1 73 m2 left ventricular hypertrophy by electro-echocardiogram b heart failure cad peripheral arterial disease stroke tia abdominal aortic aneurysm c calcium channel antagonist d renin angiotensin or at1 receptor blocker e agents are used with compelling indications</60>" ] ] ] "textoCompleto" => "<p class="elsevierStylePara"> The prevalence of hypertension (HTN), particularly difficult to control blood pressure (BP) and earlier onset of hypertension, is significantly more common in African Americans (AA) than whites. Sub-clinical manifestations of pressure-related target organ injury are also more common in AA than whites, even at blood pressure levels well below conventional HTN thresholds. This translates in the disproportionate occur rence of adverse subclinical and clinical pressure-related complications in African Americans that are consequence of suboptimal levels of blood pressure control in those with established HTN coupled with longer duration of blood pressure over their life span. According to the most recent National Health and Nutrition Examination Survey (NHANES) data, the proportion of treated patients with controlled HTN among blacks were similar to those for Hispanics but significantly lower than whites.<span class="elsevierStyleSup">1</span> These racial differences in control rates cannot be attributed to differences of awareness and treatment (reportedly been higher among blacks), nor the use of nonpharmacological/behavioral management, availability of health-insurance, economic barriers, or access to healthcare.<span class="elsevierStyleSup">2</span> The pathogenesis involves multiple mechanisms with the interaction of different factors like obesity, salt sensitivity, renin angiotensin system, and endothelium vascular response among others. The International Society on Hypertension in Blacks recommends a blood pressure goal of <130/80 mmHg. The majority of AA hypertensive patients will require combination anti-hypertensive drug therapy to meet BP goals. Monotherapy with a thiazide diuretic or a calcium channel antagonist has consistently lowered BP in this population. Angiotensin converting inhibitors and angiotensin two blockers could be used in combination with diuretics for optimal BP control and renoprotection in patients with chronic diabetic and non-diabetic kidney disease. The final goal encompasses the optimal drug combination for the control of BP and protection of target-organs. With the influx in Spain of immigrants from the African continent and Caribbean countries of African ancestry, the present review will try to explore the epidemiology, pathogenesis and treatment options in our African American (AA) population that will helps us better understand and elaborate the best therapeutic options for our patients.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Epidemiology </span></p><p class="elsevierStylePara"> Hypertension in AA is a major clinical and public-health problem because of the high prevalence and premature onset of elevated blood pressure in this population. Moreover, the common occurrence of pressure related target organ injury and high prevalence of comorbidities such as diabetes mellitus and chronic kidney disease, markedly increases the likelihood of morbidity and mortality in this group at any given blood pressure level (Table 1).</p><p class="elsevierStylePara"><img alt="Table 1 – Epidemiology of hypertension in African Americans" src="498v35n02-90411918fig1.jpg"></img></p><p class="elsevierStylePara"> Studies have shown causality between HTN, increased Body Mass index (BMI), and Sodium intake in the general population. Hypertension in the United States (US) black population has been associated with obesity (especially in women). Excess dietary sodium intake coupled with salt sensitivity, lower dietary potassium intake, excess alcohol intake, and an inadequate intake of dietary fruits and vegetables correlate with this assertion.<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara"> Changes in vascular anatomy can have a deleterious effect in blood pressure control and increase the incidence of cardiovascular events. Risk factors such as arterial stiffening and increased peripheral resistance may contribute to the development of HTN and cardiovascular disease in the general population and particularly in AA.<span class="elsevierStyleSup">4</span> Cross sectional studies, demonstrate that healthy black men can present with an increased degree of carotid hypertrophy, stiffness of the central arteries, heightened resistance artery constriction/ blunted resistance artery dilation, and greater arterial wave reflection than their white counterparts.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara"> Ethnicity has played a role in the prevalence of HTN in certain geographical areas. Data, demonstrating lower prevalence of HTN among populations of African descent from the Caribbean and rural continental Africa relative to those in the US, supports the hypotheses that environmental factors represent an important role in the development of HTN in blacks living in the US.<span class="elsevierStyleSup">6</span> This geographic variation in HTN prevalence could be attributed to differences in body mass index (BMI) and dietary sodium: potassium ratio. For example higher incidence of HTN have been seen in blacks born in southern versus northern states.</p><p class="elsevierStylePara"> In addition to environmental factors, genetic factors can contribute to HTN development and progression in blacks. Genetic underpinnings that may increase the tendency to retain sodium include: Epithelial sodium channel polymorphisms leading to cellular sodium transport defects, lower levels of renin and kinins and lower levels of natriuretic vasodilator prostaglandins amongst others.<span class="elsevierStyleSup">3</span> Multiple single nucleotide polymorphisms that may be significant in their relationship to systolic blood pressure have been also identified (SLC24A4 and CACANA1H) and are reasonable potential candidates for BP regulation involving sodium, potassium, and calcium exchanges.<span class="elsevierStyleSup">7</span></p><p class="elsevierStylePara"> Blacks in the US demonstrate excess cardiovascular morbidity and mortality relative to whites.<span class="elsevierStyleSup">8</span> In the recent coronar y ar ter y r isk development in young adults study (CARDIA),<span class="elsevierStyleSup">9</span> a long-term multicenter US study that enrolled young adults (ages 18-30), the cumulative incidence of systolic heart failure during 20 years of follow-up was greater among blacks (1.1% in black women and 0.9% in black men) that among whites (0.08% in white women and 0% in white men; P=0.001 for blacks versus whites) and was directly related to the increased burden of HTN. Specifically, 75% of blacks who developed systolic heart failure had HTN during the first 10 years of the study versus only 12% of blacks without HTN (P<0.001). Further, elevated BP remained a significant risk factor for systolic heart failure throughout the study (P<0.001). In the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) study, which included 1729 middle-age black subjects, echocardiography revealed a prevalence of left ventricular hypertrophy (LVH) of 37% in black man and 41% in black women.<span class="elsevierStyleSup">10</span> Racial causality was not feasible since there were no whites in the cohort. Other population-based studies have shown increased prevalence of LVH in blacks versus whites. Prevalence that persists even after adjustment for conventional demographics and clinical risk factors, including age, gender, height, and BMI.<span class="elsevierStyleSup">11</span> Left ventricular mass and its geometry are independent and strong risk factors for cardiovascular morbidity and death. The cohort study by Liao et al. evaluated 1089 black patients, who underwent both coronary angiography and M-mode echocardiography, and found that LVH without coexistent obstructive coronary artery disease was associated with lower survival rate than patients with single-vessel disease and similar survival rate as multiple vessel disease.<span class="elsevierStyleSup">12</span> Baseline data from the Multi-Ethnic Study of Atherosclerosis (MESA), which enrolled 6814 patients from four racial/ethnic subgroups (whites, blacks, Hispanics, and Asians) with no cardiovascular disease, revealed direct relationship between the ventricular mass and well establish risk factors such as systolic blood pressure, current smoking, exercise, BMI, and diabetes.<span class="elsevierStyleSup">13</span></p><p class="elsevierStylePara"> As described above. The cardiovascular and renal consequences of HTN are greater in blacks, relative to their white counterparts. Structural vascular abnormalities as well as genetic, geographic, and environmental factors may play an important role. The relationship between LVH and cardiovascular outcomes is particularly strong. These findings underscores the urgent need to successfully treat hypertension in the black population with agents that could reverse LVH.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Pathogenesis </span></p><p class="elsevierStylePara"> There are several pathophysiological mechanisms linked to the development of HTN and are disproportionately prevalent in selected racial/ethnic groups like AA (Table 2).</p><p class="elsevierStylePara"><img alt="Table 2 – Pathogenesis of Hypertension in African Americans37" src="498v35n02-90411918fig2.jpg"></img></p><p class="elsevierStylePara"> Obesity contributes significantly to HTN in all populations. Is more prevalent in both AA and Hispanics, particularly in women, compared with whites.<span class="elsevierStyleSup">14</span> One in six AA women are considered extremely obese (BMI>40 kg/m<span class="elsevierStyleSup">2</span>). This prevalence is almost fourfold higher than that of their white or Hispanic counterparts. Obesity related physiological effects that contribute to this BP phenotype include; enhanced sympathetic activity, altered salt sensitivity, and resistance to antihypertensive drug therapy, not to mention chronic renal injury due to glomerular hyperfiltration.<span class="elsevierStyleSup">15</span></p><p class="elsevierStylePara"> Salt sensitivity is prevalent in AA, particularly those with HTN. Conceptually defined as a rise in BP during salt administration and/or a fall in BP when it is restricted. Weight loss ameliorates salt sensitivity at least among overweight Caucasian adolescents.<span class="elsevierStyleSup">16</span> Salt sensitivity has also been linked to a lesser fall in nocturnal BP (no-dipping) as well as to microalbuminuria and other pressure-related target-organ injuries in AA.</p><p class="elsevierStylePara"> The role of the renin-angiotensin system (RAAS) in AA has not been clearly defined but the pattern of excessive RAAS dependent target-organ injury (LVH, CKD/proteinuria) in AA, showcases the importance of the RAAS in this population. This does not explain the lack of BP reduction with the use of ACE inhibitors compared with diuretics.<span class="elsevierStyleSup">17</span> A possible reason is that low renin levels increase the vascular production of angiotensin II promoting the fibrotic effects of aldosterone. Normotensive AA patients present with activation of the RAAS with higher aldosterone levels in comparison with whites. and AA with non-diabetic nephropathy experience less renal events when treated with an ACE inhibitor.<span class="elsevierStyleSup">18</span> Angiotensin two blockers in combination with a thiazide diuretic are as effective as calcium channel blockers (CCB) and thiazides in reducing BP in obese hypertensive AA.<span class="elsevierStyleSup">19</span> A combination of a CCB and a RAAS blockade in uncontrolled BP(>15/10 mmHg of baseline 130/80) is indicated in AA hypertensives, in the absence of compelling indications for another drug class. Paradoxically the hypothesis behind vitamin D deficiency and incidence of HTN has been linked to activation of the RAAS in this population and its supplementation could suppress its activity and maybe control blood pressure.<span class="elsevierStyleSup">20</span></p><p class="elsevierStylePara"> The endothelium presents as a target to the deleterious effects of RAAS activation. Endothelium-dependent and independent vascular responses are abnormal in AA compared with whites.<span class="elsevierStyleSup">21</span> There are also explanatory data suggesting that the bioavailability of nitric oxide is lower in AA than whites even though AA have much higher endothelial-derived nitric oxide synthase (eNOS) activity.<span class="elsevierStyleSup">22</span></p><p class="elsevierStylePara"> Resistant HTN is more prevalent in AA than in Whites.<span class="elsevierStyleSup">23</span> They manifest the characteristics comorbidities (albuminuria, depressed kidney function, obesity,target-organ injury, diabetes, and severe BP elevations) that have been linked to antihypertensive drug resistance and therefore lesser HTN control.<span class="elsevierStyleSup">23</span> Wether poor BP control reflects true resistance HTN or other contributory factors such us lack of compliance or low socioeconomic status remains to be determine.</p><p class="elsevierStylePara"> Obesity, salt sensitivity, RAAS, and endothelial activation represent different factors affecting the pathogenesis of HTN. The understanding of how this factors influence BP will guide the development of treatment protocols that will optimize the way we implement diet, physical activity and drug therapy. Elucidating this complex pathogenesis will also help guide therapies in the future.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Treatment </span></p><p class="elsevierStylePara"> Optimal treatment of HTN requires an approach that encompasses multifactorial lifestyle modifications (weight loss, salt,alcohol restriction, and increased physical activity) plus drug therapy. The consensus statement on the treatment of HTN in AA from the International Society on Hypertension in Blacks (ISHIB) recommends comprehensive lifestyle modification in all AA with a BP>115/75 mmHg.<span class="elsevierStyleSup">23</span> This is the BP level above which epidemiological cardiovascular disease risk begins its upward inflection. In contrast to the JNC 8 recommendations for the treatment of HTN,<span class="elsevierStyleSup">24</span> the ISHIB target BP goals remain lower (<130/80 mmHg), especially in certain risk groups (CKD,Diabetes,cardiovascular disease).<span class="elsevierStyleSup">25</span> The American Diabetes Association (ADA) recommends a target BP for diabetics of <140/90 mmHg.<span class="elsevierStyleSup">26</span> Data that correlates from previous studies that showed fewer strokes in cohorts with SBP control below 10 mmHg lower than baseline and <120 mmHg respectively.<span class="elsevierStyleSup">27</span></p><p class="elsevierStylePara"> There is also convincing data of renal outcomes for attaining mean arterial pressure (MAP) <92 mmHg compared to MAP of 102-107 amongst AA with HTN and non-diabetic nephropathy (urine protein/creatinine ratio >0.22).<span class="elsevierStyleSup">18</span></p><p class="elsevierStylePara"> We now present the different therapeutic options by order of importance and clinical efficacy. The focus of drug therapy in AA is centered on the BP lowering efficacy of single drug classes. Unfortunately the majority will not be controlled with a single agent. Monotherapy with a thiazide diuretic or a calcium channel antagonist has consistently lowered BP more effectively than β-blockers, ACE inhibitors, and angiotensin II type 1 receptor antagonists.<span class="elsevierStyleSup">28</span> As mentioned above, the majority of AA hypertensive will require combination anti-hypertensive drug therapy to control their BP and there are no discernable racial/ethnic differences in BP response to two-drug antihypertensive therapy if at least one of the drugs is either a diuretic or a calcium channel antagonist. Highly effective drug combinations contain either a diuretic or a calcium channel antagonist in conjunction with a RAS antagonist. In the ACCOMPLISH<span class="elsevierStyleSup">29</span> (avoiding cardiovascular events through combination therapy in patients living with systolic hypertension) study amlodipine plus benazepril showed superiority over hydrochlorothiazide (HCTZ) plus benazepril combination in the black cohort (n=1416) particularly in patients with cardiovascular risk factors and diabetes mellitus. Thus, there are a number of relatively ineffective anti-hypertensive drug combinations that should not be used as first line agents to control hypertension (ACE inhibitors or ARB alone, peripheral and central-acting adrenergic inhibitors) in this population, except if target organ damage is present (CKD, Diabetic nephropathy). It is important to understand that the attainment of a clinical benefit is somewhat dependent on patient adherence. This has prompted recommendations for the use of single-pill fixed dose combinations.</p><p class="elsevierStylePara"> Diuretics play a prominent role in AA with refractory HTN. The reason for this is not plasma volume expansion despite the prevalence of a salt sensitivity state, since the effect is transient in animal and human models of HTN.<span class="elsevierStyleSup">30</span> The use of more than one diuretic will be needed to control BP particularly in patients with estimated glomerular filtration rate <40 ml/ Min (eGFR). Hydroclorothiazide plus an aldosterone antagonist or amiloride are used in patients with eGFR>50 mL/min/1.73 m<span class="elsevierStyleSup">2</span> and have shown benefits when combine with loop diuretics, particularly in patients with advanced heart failure. In patients with eGFR of 30-45 mL/min/1.73 m<span class="elsevierStyleSup">2</span>, the combination of a thiazide and a loop diuretic represents and effective option.<span class="elsevierStyleSup">31</span></p><p class="elsevierStylePara"> In the recent revision of the ISHIB consensus statement on the management of hypertension in AA<span class="elsevierStyleSup">25,32</span> the use of chlorthalidone over HCTZ was favored due to the fact that it lowered BP more effectively than HCTZ on a mg per mg basis, especially at night (longer half-life). The downside being the pill burden, intravascular volume depletion and consequent pre-renal azotemia.</p><p class="elsevierStylePara"> Given the high level of pre-treatment salt sensitivity and the salt retaining effect of many antihypertensives (particularly vasodilators:minoxidil), coupled with the prevalence of obesity in this population, comprehensive lifestyle modification that entails dietary salt, higher intake of potassium and weight loss should be implemented. The ladder could lessen salt sensitivity and restore the “dipping” nocturnal effect of BP.<span class="elsevierStyleSup">33</span></p><p class="elsevierStylePara"> There are multiple side effects that need to be taken in consideration when using different antihypertensives agents. As previously stated before angiotensin converting enzyme inhibitors and angiotensin two blockers could be used in combination with diuretics for optimal BP control and renoprotection in patients with diabetic and non-diabetic kidney disease. The clinician should be aware that angioedema occurs more in A A than whites dur ing ACE inhibition treatment. Angioedema is less frequent with the use of ARB or direct renin inhibitors agents.<span class="elsevierStyleSup">34</span></p><p class="elsevierStylePara"> Hypertension treatment in AA has evolved during the years. The goal is to use the most effective drug combination for the control of BP and protection of target-organs. In order to comply with the ISHIB recommendations for reduction of BP, optimal management of HTN in AA will require the use of comprehensive life style modifications and individualized drug combinations.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conclusion </span></p><p class="elsevierStylePara"> The prevalence of HTN is higher in blacks than in other race/ ethnic groups, with environmental and genetic risk factors playing an important role.<span class="elsevierStyleSup">35</span> The cardiovascular and renal complications of HTN are also greater in blacks relative to their white counterparts. Target organ damage such as LVH and renal failure are more common in blacks than whites, even after comparable levels of BP.<span class="elsevierStyleSup">31</span> The pathogenesis is multifactorial in nature, complicating therapeutic options and requiring a multidisciplinary approach. Emphasis should be placed on utilizing the most effective drug combination for the control of BP and protection of target-organs in this high risk population. The ISHIB consensus statement (Fig. 1) recommends a reduction in the BP target, even for the lowest risk AA population (<135/85 mmHg) for primary prevention and <130/80 mmHg for secondary prevention with target-organ damage present. As previously stated, this will require the use of comprehensive life-style modifications coupled with drug therapies tailored to different comorbidities.<span class="elsevierStyleSup">36</span></p><p class="elsevierStylePara"><img alt="Figure 1 – Treatment of hypertension in African Americans vs Whites. a Albumin:creatinine >200 mg/g, eGFR <60 mL/min 1.73 m2, left ventricular hypertrophy by electro-echocardiogram. b Heart Failure, CAD, peripheral arterial disease, stroke, TIA,abdominal aortic aneurysm. c Calcium channel antagonist. d Renin angiotensin or AT1 receptor blocker. e Agents are used with compelling indications." src="498v35n02-90411918fig3.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 1 – Treatment of hypertension in African Americans vs Whites. <span class="elsevierStyleSup">a</span> Albumin:creatinine >200 mg/g, eGFR <60 mL/min 1.73 m<span class="elsevierStyleSup">2</span>, left ventricular hypertrophy by electro-echocardiogram. <span class="elsevierStyleSup">b</span> Heart Failure, CAD, peripheral arterial disease, stroke, TIA,abdominal aortic aneurysm. <span class="elsevierStyleSup">c</span> Calcium channel antagonist. <span class="elsevierStyleSup">d</span> Renin angiotensin or AT1 receptor blocker. e Agents are used with compelling indications.</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Key points </span></p><p class="elsevierStylePara"> • Hypertension is prevalent in the African American population.</p><p class="elsevierStylePara"> • Epidemiology is influenced by ethnicity and genetics.</p><p class="elsevierStylePara"> • Multifactorial pathogenesis influenced by obesity, salt sensitivity, activation of the RAAS, among other causes.</p><p class="elsevierStylePara"> • Therapeutic antihypertensive options similar to whites with slight variations in blood pressure goals based on recommendat ions from the Inter nat ional Societ y of Hypertension in Blacks.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Funding </span></p><p class="elsevierStylePara"> None.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interests </span></p><p class="elsevierStylePara"> The authors declare that they have no conflicto of interests.</p><hr></hr><p class="elsevierStylePara"> * <span class="elsevierStyleItalic">Corresponding author</span>.<br></br> Luis M Ortega, Division of Nephrology and Hypertension, <br></br> Allegheny General Hospital/Temple University School of Medicine, 320 East North Ave, 15212, <br></br> Pittsburgh, Pennsylvania, USA. <br></br> Tel: (412)359-3319.<br></br><span class="elsevierStyleItalic">E-mail:</span><a href="mailto:lortega@wpahs.org" class="elsevierStyleCrossRefs">lortega@wpahs.org</a></p>" "pdfFichero" => "498v35n02a90411918pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec503477" "palabras" => array:5 [ 0 => "Hipertensión" 1 => "Afroamericanos" 2 => "Epidemiología de la hipertensión" 3 => "Patogénesis de la hipertensión" 4 => "Antihipertensivos para afroamericanos" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec503478" "palabras" => array:6 [ 0 => "Hypertension" 1 => "African American" 2 => "Epidemiology of hypertension" 3 => "Pathogenesis of hypertension" 4 => "Antihypertensives for African" 5 => "Americans" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<p class="elsevierStylePara"> La hipertensión arterial es prevalente en la población de raza negra en los EEUU. Presenta una relación directa con el daño cardiovascular y renal. Su patogenia es compleja e incluye la alta incidencia de obesidad, sensibilidad a la sal, y la consecuente activación del sistema de la renina, angiotensina y aldosterona. Eso hace que requiera una combinación terapéutica que incluye cambios dietéticos y regímenes antihipertensivos adecuados. La Sociedad internacional de la hipertensión en pacientes de raza negra recomienda iniciar dietas de control para valores de tensión arterial sistólica/diastólica por encima de los 115/75 mmHg y mantener una tensión arterial por debajo de 135/85 mmHg con el uso de medicación antihipertensiva idónea. El fármaco antihipertensivo adecuado está por determinar en esta población.</p>" ] "en" => array:1 [ "resumen" => "<p class="elsevierStylePara"> Arterial hypertension is prevalent in the black population in the United States. It is directly related to cardiovascular and kidney damage. Its pathogenesis is complex and includes the high incidence of obesity, salt sensitivity and the activation of the renin-angiotensin-aldosterone system. This complexity requires a therapeutic combination that includes changes in dietary habits and appropriate antihypertensive regimes. The International Society of Hypertension in Blacks recommends initiating dietary intervention for values of systolic/ diastolic arterial blood pressure above 115/75 mmHg and maintaining arterial blood pressure below 135/85 mmHg using appropiate antihypertensive medication. The most adequate antihypertensive drug for this population has yet to be determined.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "498v35n02-90411918fig1.jpg" "imagenAlto" => 362 "imagenAncho" => 2112 "imagenTamanyo" => 102934 ] ] ] ] ] "descripcion" => array:1 [ "en" => "– Epidemiology of hypertension in African Americans" ] ] 1 => array:8 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "498v35n02-90411918fig2.jpg" "imagenAlto" => 362 "imagenAncho" => 2112 "imagenTamanyo" => 82175 ] ] ] ] ] "descripcion" => array:1 [ "en" => "– Pathogenesis of Hypertension in African Americans37" ] ] 2 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "498v35n02-90411918fig3.jpg" "Alto" => 1200 "Ancho" => 2037 "Tamanyo" => 210277 ] ] "descripcion" => array:1 [ "en" => "– Treatment of hypertension in African Americans vs Whites. a Albumin:creatinine >200 mg/g, eGFR <60 ml min 1 73 m2 left ventricular hypertrophy by electro-echocardiogram b heart failure cad peripheral arterial disease stroke tia abdominal aortic aneurysm c calcium channel antagonist d renin angiotensin or at1 receptor blocker e agents are used with compelling indications</60>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA. 2010;303:2043-50. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Egan BM" 1 => "Zhao Y" 2 => "Axon RN." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2010.650" "Revista" => array:6 [ "tituloSerie" => "JAMA. " "fecha" => "2010" "volumen" => "303" "paginaInicial" => "2043" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20501926" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Racial differences in blood pressure control: potential explanatory factors. Am J Med. 2006;119;e9-70. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Racial differences in blood pressure control: potential explanatory factors." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Bosworth HB" 1 => "Dudley T" 2 => "Olsen MK" 3 => "Voils CI" 4 => "Powers B" 5 => "Goldstein" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2006.02.028" "Revista" => array:6 [ "tituloSerie" => "Am J Med. " "fecha" => "2006" "volumen" => "119" "paginaInicial" => "e9" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17145255" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Race-based therapy for hypertension: Possible benefits and potential pitfalls. Expert Rev Cardiovasc Ther. 2008;6:1357-66. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19018689" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Race-based therapy for hypertension: Possible benefits and potential pitfalls." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Ferdinand KC" 1 => "Ferdinand DP." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1586/14779072.6.10.1357" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Cardiovasc Ther. " "fecha" => "2008" "volumen" => "6" "paginaInicial" => "1357" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19018689" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Function and structure of resistance vessels in black and white people. J Clin Hypertens. 2010;12:431-8. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Function and structure of resistance vessels in black and white people." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Taherzadeh Z" 1 => "Brewster LM" 2 => "Van Montfrans GA" 3 => "Van Bavel E." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Hypertens. " "fecha" => "2010" "volumen" => "12" "paginaInicial" => "431" "paginaFinal" => "8" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Racial differences in central blood pressure and vascular function in young man. Am J Physiol Heart Circ Physiol. 2008;295:H2380-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18849329" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Racial differences in central blood pressure and vascular function in young man." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Heffernan KS" 1 => "Jae SY" 2 => "Wilund KR" 3 => "Woods JA" 4 => "Fernhall B." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpheart.00902.2008" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Heart Circ Physiol. " "fecha" => "2008" "volumen" => "295" "paginaInicial" => "H2380" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18849329" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The prevalence of hypertension in seven populations of West African origin. Am J Public Health. 1997;87:160-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9103091" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The prevalence of hypertension in seven populations of West African origin." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Cooper R" 1 => "Rotimi C" 2 => "Ataman S" 3 => "McGee D" 4 => "Osotimehin B" 5 => "Kadiri S" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Public Health. " "fecha" => "1997" "volumen" => "87" "paginaInicial" => "160" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9103091" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "A genome-wide association study of hypertension and blood pressure in African Americans. PloS Genet. 2009; 5:e1000564. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19609347" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "A genome-wide association study of hypertension and blood pressure in African Americans." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Adeyemo A" 1 => "Gerry N" 2 => "Chen G" 3 => "Herbert A" 4 => "Doumatey A" 5 => "Huang H" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pgen.1000564" "Revista" => array:5 [ "tituloSerie" => "PloS Genet. " "fecha" => "2009" "volumen" => "5" "paginaInicial" => "e1000564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19609347" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Pathophysiology and treatment implications of hypertension in the African American population. Endocrinol Metab Clin North Am. 1997;26;125-44. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9074856" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Pathophysiology and treatment implications of hypertension in the African American population." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Rahman M" 1 => "Douglas JG" 2 => "Wright Jr JT." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Endocrinol Metab Clin North Am. " "fecha" => "1997" "volumen" => "26" "paginaInicial" => "125" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9074856" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Racial differences in incident heart failure among young adults. N Engl J Med. 2009;360:1179-90. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19297571" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Racial differences in incident heart failure among young adults." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Bibbins-Domingo K" 1 => "Pletcher MJ" 2 => "Lin F" 3 => "Vittinhoff E" 4 => "Gardin JM" 5 => "Arynchyn A" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0807265" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med. " "fecha" => "2009" "volumen" => "360" "paginaInicial" => "1179" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19297571" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Body mass index and blood pressure influences on left ventricular mass and geometry in African Americans: The Atherosclerotic Risk In Communities (ARIC) Study. Hypertension. 2004;44:55-60. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Body mass index and blood pressure influences on left ventricular mass and geometry in African Americans: The Atherosclerotic Risk In Communities (ARIC) Study." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Fox E" 1 => "Taylor H" 2 => "Andrew M" 3 => "Han H" 4 => "Mohamed E" 5 => "Garrison R" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000132373.26489.58" "Revista" => array:6 [ "tituloSerie" => "Hypertension. " "fecha" => "2004" "volumen" => "44" "paginaInicial" => "55" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15184348" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Differences in left ventricular structure between black and white hypertensive adults: The Hypertension Genetic Epidemiology Network study. Hypertension. 2004;43;1182-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15123573" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Differences in left ventricular structure between black and white hypertensive adults: The Hypertension Genetic Epidemiology Network study." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Kuizer JR" 1 => "Arnett DK" 2 => "Bella JN" 3 => "Paranicas M" 4 => "Rao DC" 5 => "Province MA" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000128738.94190.9f" "Revista" => array:6 [ "tituloSerie" => "Hypertension. " "fecha" => "2004" "volumen" => "43" "paginaInicial" => "1182" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15123573" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The relative effect of left ventricular hypertrophy, coronary activity disease, and ventricular dysfunction on survival among black adults. JAMA. 1995;273:1592-7. <a href="http://www.ncbi.nlm.nih.gov/pubmed/7745772" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The relative effect of left ventricular hypertrophy, coronary activity disease, and ventricular dysfunction on survival among black adults." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Liao Y" 1 => "Cooper RS" 2 => "McGee DL" 3 => "Mensah GA" 4 => "Ghali JK." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA. " "fecha" => "1995" "volumen" => "273" "paginaInicial" => "1592" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7745772" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: The Multi-ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2006;48:2285-92. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17161261" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: The Multi-ethnic Study of Atherosclerosis." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Heckbert SR" 1 => "Post W" 2 => "Pearson GD" 3 => "Arnett DK" 4 => "Gomes AS" 5 => "Jerosch-Herold M" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2006.03.072" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol. " "fecha" => "2006" "volumen" => "48" "paginaInicial" => "2285" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17161261" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Overweight and obesity in the United States: prevalence and trends, 1960/1994. Int J Obes Relat Metab Disord. 1998;22:39-47. <a href="http://www.ncbi.nlm.nih.gov/pubmed/9481598" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Overweight and obesity in the United States: prevalence and trends, 1960/1994." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Flegal KM" 1 => "Carroll MD" 2 => "Kuczmerski RJ" 3 => "Johnson CL." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Obes Relat Metab Disord. " "fecha" => "1998" "volumen" => "22" "paginaInicial" => "39" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9481598" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Obesity, hypertension, salt sensitivity and insulin resistance. Nutr Metab Cardiovasc Dis. 2000;10:287-94. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11213538" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Obesity, hypertension, salt sensitivity and insulin resistance." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Rocchini AP." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nutr Metab Cardiovasc Dis. " "fecha" => "2000" "volumen" => "10" "paginaInicial" => "287" "paginaFinal" => "94" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11213538" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "New salt-sensitivity metrics: variability-adjusted blood pressure change and urinary sodium to creatinine ratio. Ethn Dis. 2002;12:10-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11913598" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "New salt-sensitivity metrics: variability-adjusted blood pressure change and urinary sodium to creatinine ratio." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Flack JM" 1 => "Grimm RH Jr" 2 => "Staffileno B" 3 => "Dnsc" 4 => "Elmer P" 5 => "Hedquist L" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ethn Dis. " "fecha" => "2002" "volumen" => "12" "paginaInicial" => "10" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11913598" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Renal perfusion and function in healthy African Americans. Kidney Int. 2001;59:1037-43. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11231358" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Renal perfusion and function in healthy African Americans." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Price DA" 1 => "Fisher ND" 2 => "Osei SY" 3 => "Lansang MC" 4 => "Hollenberg MK." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2001.0590031037.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int. " "fecha" => "2001" "volumen" => "59" "paginaInicial" => "1037" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11231358" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease. Results from the AASK trial. JAMA. 2002;288:2421-3. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease. Results from the AASK trial." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Wright JT" 1 => "Brakis G" 2 => "Greene T" 3 => "Agodoa LY" 4 => "Appel LJ" 5 => "Charleston J" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA. " "fecha" => "2002" "volumen" => "288" "paginaInicial" => "2421" "paginaFinal" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12435255" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Antihypertensive and metabolic effects of angiotensin receptor blocker/diuretic combination therapy in obese hypertensive African Americans and White patients. Am J Ther. 2013;20:2-12. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22248871" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Antihypertensive and metabolic effects of angiotensin receptor blocker/diuretic combination therapy in obese hypertensive African Americans and White patients." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Ofili EO" 1 => "Zappe DH" 2 => "Purkayastha D" 3 => "Samuel R" 4 => "Sowers JR." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MJT.0b013e318230ae66" "Revista" => array:6 [ "tituloSerie" => "Am J Ther. " "fecha" => "2013" "volumen" => "20" "paginaInicial" => "2" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22248871" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Vitamin D, blood pressure, and African Americans: Toward a unifying hypotheis. Cjasn. 2010;5:1697-703. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20651156" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Vitamin D, blood pressure, and African Americans: Toward a unifying hypotheis." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Rostand SG." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2215/CJN.02960410" "Revista" => array:6 [ "tituloSerie" => "Cjasn. " "fecha" => "2010" "volumen" => "5" "paginaInicial" => "1697" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20651156" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The presence of African American race predicts improvement in coronary endothelial function after suplemmentary L-arginine. J Am Coll Cardiol. 2002;39:1314-22. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11955849" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The presence of African American race predicts improvement in coronary endothelial function after suplemmentary L-arginine." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Houghton JL" 1 => "Philbin EF" 2 => "Strogatz DS" 3 => "Torosoff MT" 4 => "Fein SA" 5 => "Kunher PA" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol. " "fecha" => "2002" "volumen" => "39" "paginaInicial" => "1314" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11955849" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Understanding nitric oxide physiology in the heart: a nanomedical approach. Am J Cardiol. 2005;96 Suppl:13i-24i. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Understanding nitric oxide physiology in the heart: a nanomedical approach." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Malinski T." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Cardiol. " "fecha" => "2005" "volumen" => "96 Suppl" "paginaInicial" => "13i" "paginaFinal" => "24i" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. International Society on Hypertension in Blacks. Hypertension. 2010;56:780-800. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Management of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statement. International Society on Hypertension in Blacks." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Flack JM" 1 => "Sica DA" 2 => "Bakris G" 3 => "Brown Al" 4 => "Ferdinand KC" 5 => "Grimm RH Jr" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/HYPERTENSIONAHA.110.152892" "Revista" => array:6 [ "tituloSerie" => "Hypertension. " "fecha" => "2010" "volumen" => "56" "paginaInicial" => "780" "paginaFinal" => "800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20921433" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "2014 evidence guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee(JNC8). JAMA. 2014;311:507-20. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24352797" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "2014 evidence guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee(JNC8)." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "James P" 1 => "Oparil S" 2 => "Carter BL" 3 => "Cushman WC" 4 => "Dennison-Himmelfarb C" 5 => "Handler J" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2013.284427" "Revista" => array:6 [ "tituloSerie" => "JAMA. " "fecha" => "2014" "volumen" => "311" "paginaInicial" => "507" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24352797" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Does earlier attaintment of blood pressure goal translate into fewer cardiovascular events? Curr Hypertens Resp. 2008;10:398-404. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Does earlier attaintment of blood pressure goal translate into fewer cardiovascular events? Curr Hypertens Resp." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Nasser SA" 1 => "Lai Z" 2 => "O’Connor S" 3 => "Liu X" 4 => "Flack JM." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "2008" "volumen" => "10" "paginaInicial" => "398" "paginaFinal" => "404" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Standards of medical care in diabetes-2013. Diabetes Care. 2013;36:S11-S66. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Standards of medical care in diabetes-2013." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Diabetes Association." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/dc13-S011" "Revista" => array:6 [ "tituloSerie" => "Diabetes Care. " "fecha" => "2013" "volumen" => "36" "paginaInicial" => "S11" "paginaFinal" => "S66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23264422" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int. 2002;61:1086-97. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11849464" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Schrier RW" 1 => "Estacio RO" 2 => "Esler A" 3 => "Mehler P." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2002.00213.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int. " "fecha" => "2002" "volumen" => "61" "paginaInicial" => "1086" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11849464" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and Lisinopril. JAMA. 2005;293;1595-608. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and Lisinopril." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Wright JT" 1 => "Dunn JK" 2 => "Cutler JA" 3 => "Davis BR" 4 => "Cushman WC" 5 => "Ford CE" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.293.13.1595" "Revista" => array:6 [ "tituloSerie" => "JAMA. " "fecha" => "2005" "volumen" => "293" "paginaInicial" => "1595" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15811979" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Benazepril and amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359: 2417-28. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19052124" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Benazepril and amlodipine or hydrochlorothiazide for hypertension in high-risk patients." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Jameson K" 1 => "Weber MA" 2 => "Bakris GL" 3 => "Dahlof V" 4 => "Pitt B" 5 => "Sih V" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0806182" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med. " "fecha" => "2008" "volumen" => "359" "paginaInicial" => "2417" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19052124" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Diuretics, arteriolar resistance and arteriolar compliance in human hypertension. Eur Heart J. 1992;13:48-52. <a href="http://www.ncbi.nlm.nih.gov/pubmed/1486905" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Diuretics, arteriolar resistance and arteriolar compliance in human hypertension." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Levenson J" 1 => "Gariepy J" 2 => "Megnien JL" 3 => "Merli IP" 4 => "Simon A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Heart J. " "fecha" => "1992" "volumen" => "13" "paginaInicial" => "48" "paginaFinal" => "52" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1486905" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Therapy of hypertension in African Americans. Am J Cardiovasc Drugs. 2011;11:83-92. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21446775" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Therapy of hypertension in African Americans." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Flack JM" 1 => "Nasser SA" 2 => "Levy PD." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2165/11586930-000000000-00000" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiovasc Drugs. " "fecha" => "2011" "volumen" => "11" "paginaInicial" => "83" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21446775" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Comparative antihypertensive effects of hydroclorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension. 2006;47:352-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16432050" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Comparative antihypertensive effects of hydroclorothiazide and chlorthalidone on ambulatory and office blood pressure." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Ernst ME" 1 => "Carter BL" 2 => "Goerdt CJ" 3 => "Steffensmeir JJ" 4 => "PhilLips BB" 5 => "Zimmerman MM" 6 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000203309.07140.d3" "Revista" => array:6 [ "tituloSerie" => "Hypertension. " "fecha" => "2006" "volumen" => "47" "paginaInicial" => "352" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16432050" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Effects of potassium on blood pressure in salt-sensitive and salt-resistant black adolescents. Hypertension. 1999;34:181-9. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Effects of potassium on blood pressure in salt-sensitive and salt-resistant black adolescents." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Wilson DK" 1 => "Sica DA" 2 => "Miller SB." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension. " "fecha" => "1999" "volumen" => "34" "paginaInicial" => "181" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10454438" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema. Clin Pharmacol Ther. 1996;60:8-13. <a href="http://www.ncbi.nlm.nih.gov/pubmed/8689816" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Brown NJ" 1 => "Ray WA" 2 => "Snowden M" 3 => "Griffin MR." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0009-9236(96)90161-7" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther. " "fecha" => "1996" "volumen" => "60" "paginaInicial" => "8" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8689816" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hypertension in the US population: risk factors, complications, and potential impact of central aortic pressure on effective treatment. Cardiovasc Drugs. 2012;26:157-65. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Hypertension in the US population: risk factors, complications, and potential impact of central aortic pressure on effective treatment." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Ferdinand KC" 1 => "Townsend RR." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cardiovasc Drugs. " "fecha" => "2012" "volumen" => "26" "paginaInicial" => "157" "paginaFinal" => "65" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Should African Americans with hypertension be treated differently than non-African Americans? Curr Hypertens Rep. 2014;16:409. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Should African Americans with hypertension be treated differently than non-African Americans? Curr Hypertens Rep." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Flack JM" 1 => "Ference BA" 2 => "Levy P." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "fecha" => "2014" "volumen" => "16" "paginaInicial" => "409" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003500000002/v0_201504231604/X2013251415119180/v0_201504231605/en/main.assets" "Apartado" => array:4 [ "identificador" => "38707" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Brief reviews" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003500000002/v0_201504231604/X2013251415119180/v0_201504231605/en/498v35n02a90411918pdf001.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251415119180?idApp=UINPBA000064" ]
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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 5 | 12 |
| 2024 October | 74 | 29 | 103 |
| 2024 September | 91 | 29 | 120 |
| 2024 August | 79 | 45 | 124 |
| 2024 July | 61 | 24 | 85 |
| 2024 June | 80 | 52 | 132 |
| 2024 May | 57 | 31 | 88 |
| 2024 April | 43 | 29 | 72 |
| 2024 March | 34 | 26 | 60 |
| 2024 February | 49 | 36 | 85 |
| 2024 January | 46 | 29 | 75 |
| 2023 December | 39 | 27 | 66 |
| 2023 November | 50 | 39 | 89 |
| 2023 October | 65 | 15 | 80 |
| 2023 September | 48 | 21 | 69 |
| 2023 August | 27 | 19 | 46 |
| 2023 July | 37 | 28 | 65 |
| 2023 June | 35 | 23 | 58 |
| 2023 May | 45 | 49 | 94 |
| 2023 April | 28 | 12 | 40 |
| 2023 March | 32 | 17 | 49 |
| 2023 February | 24 | 21 | 45 |
| 2023 January | 36 | 26 | 62 |
| 2022 December | 49 | 20 | 69 |
| 2022 November | 36 | 21 | 57 |
| 2022 October | 40 | 43 | 83 |
| 2022 September | 42 | 26 | 68 |
| 2022 August | 40 | 36 | 76 |
| 2022 July | 33 | 43 | 76 |
| 2022 June | 35 | 27 | 62 |
| 2022 May | 28 | 34 | 62 |
| 2022 April | 42 | 45 | 87 |
| 2022 March | 39 | 49 | 88 |
| 2022 February | 37 | 36 | 73 |
| 2022 January | 39 | 37 | 76 |
| 2021 December | 33 | 36 | 69 |
| 2021 November | 34 | 32 | 66 |
| 2021 October | 47 | 38 | 85 |
| 2021 September | 34 | 31 | 65 |
| 2021 August | 34 | 34 | 68 |
| 2021 July | 35 | 30 | 65 |
| 2021 June | 30 | 15 | 45 |
| 2021 May | 38 | 38 | 76 |
| 2021 April | 59 | 33 | 92 |
| 2021 March | 40 | 33 | 73 |
| 2021 February | 20 | 13 | 33 |
| 2021 January | 48 | 14 | 62 |
| 2020 December | 31 | 12 | 43 |
| 2020 November | 31 | 7 | 38 |
| 2020 October | 32 | 20 | 52 |
| 2020 September | 33 | 14 | 47 |
| 2020 August | 42 | 9 | 51 |
| 2020 July | 33 | 10 | 43 |
| 2020 June | 28 | 4 | 32 |
| 2020 May | 48 | 16 | 64 |
| 2020 April | 53 | 24 | 77 |
| 2020 March | 44 | 16 | 60 |
| 2020 February | 55 | 21 | 76 |
| 2020 January | 54 | 18 | 72 |
| 2019 December | 99 | 23 | 122 |
| 2019 November | 67 | 23 | 90 |
| 2019 October | 47 | 9 | 56 |
| 2019 September | 60 | 19 | 79 |
| 2019 August | 44 | 18 | 62 |
| 2019 July | 35 | 19 | 54 |
| 2019 June | 42 | 18 | 60 |
| 2019 May | 24 | 11 | 35 |
| 2019 April | 62 | 19 | 81 |
| 2019 March | 32 | 18 | 50 |
| 2019 February | 15 | 10 | 25 |
| 2019 January | 36 | 21 | 57 |
| 2018 December | 78 | 40 | 118 |
| 2018 November | 99 | 14 | 113 |
| 2018 October | 91 | 15 | 106 |
| 2018 September | 63 | 11 | 74 |
| 2018 August | 57 | 20 | 77 |
| 2018 July | 40 | 13 | 53 |
| 2018 June | 43 | 12 | 55 |
| 2018 May | 45 | 13 | 58 |
| 2018 April | 37 | 5 | 42 |
| 2018 March | 45 | 10 | 55 |
| 2018 February | 29 | 3 | 32 |
| 2018 January | 27 | 5 | 32 |
| 2017 December | 30 | 8 | 38 |
| 2017 November | 38 | 9 | 47 |
| 2017 October | 38 | 5 | 43 |
| 2017 September | 45 | 5 | 50 |
| 2017 August | 45 | 6 | 51 |
| 2017 July | 60 | 20 | 80 |
| 2017 June | 55 | 21 | 76 |
| 2017 May | 76 | 21 | 97 |
| 2017 April | 73 | 13 | 86 |
| 2017 March | 54 | 15 | 69 |
| 2017 February | 49 | 11 | 60 |
| 2017 January | 49 | 11 | 60 |
| 2016 December | 80 | 14 | 94 |
| 2016 November | 107 | 11 | 118 |
| 2016 October | 123 | 15 | 138 |
| 2016 September | 162 | 3 | 165 |
| 2016 August | 232 | 0 | 232 |
| 2016 July | 236 | 0 | 236 |
| 2016 June | 170 | 0 | 170 |
| 2016 May | 156 | 0 | 156 |
| 2016 April | 131 | 0 | 131 |
| 2016 March | 148 | 0 | 148 |
| 2016 February | 181 | 0 | 181 |
| 2016 January | 161 | 0 | 161 |
| 2015 December | 146 | 1 | 147 |
| 2015 November | 97 | 1 | 98 |
| 2015 October | 166 | 5 | 171 |
| 2015 September | 198 | 2 | 200 |
| 2015 August | 214 | 29 | 243 |
| 2015 July | 153 | 0 | 153 |
| 2015 June | 111 | 0 | 111 |
| 2015 May | 188 | 19 | 207 |
| 2015 April | 30 | 0 | 30 |
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