Rapid response to high cut-off haemodialysis and bortezomib therapy in a patient with acute renal failure and plasma cells dyscrasia
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Electrochemical properties of abnormal light chains are responsible for histological renal pictures. Bortezomib is the first proteasome inhibitor approved for treatment of multiple myeloma and amyloidosis. It prevents the activation of NF-kB that controls the genes encoding IL-6, TNF-alpha and other cytokines and growth factors. Our experience: a 29-year-old woman, suffering from ulcerative colitis successfully treated with sulfasalazine, without renal disease history, was admitted to hospital for acute kidney injury (creatinine 10mg/dL) and anaemia without signs of thrombotic microangiopathy. Serum protein electrophoresis showed a beta-2-monoclonal peak; the serum immunofixation was positive for λ light chains; k- and λ-free light chains (FLC) levels were 37mg/L and 1750mg/L respectively with k/λ ratio=0.02. Microbiological, coagulation and other immunological investigations were unremarkable. The patient started haemodialysis treatment. Renal biopsy revealed a cast-nephropathy picture, negative Congo-red staining, without glomerular deposits; the immunofluorescence showed k light chains but not λ light chains in tubular basement membranes. Abdominal fat biopsy was positive for AL amyloid. Bone marrow biopsy showed 10% of plasma cells infiltration without morphological or cytometric clonality markers; total body CT scan was negative for bone lesions. Because of plasma cell dyscrasia and severe renal involvement, even in absence of a diagnostic definition, was performed a combination treatment of direct removal of FLCs and chemotherapy. Following Hutchison’s studies,<span class="elsevierStyleSup">1,2</span> we performed extended haemodialysis (HD) treatment with high cut-off (HCO) dialyzers (Theralite<span class="elsevierStyleSup">®</span>, Gambro) and bortezomib 1.3mg/m<span class="elsevierStyleSup">2</span> + dexamethasone 20mg/day (days 1-4-8-11) therapy with improvement of renal function (creatinine 1,6mg/dL) and normalization of FLC chains levels (k- and λ-FLC 5mg/dL and 6mg/dL respectively with k/λ ratio=0.85) after the first chemotherapy cycle and 7 HCO-HD. Later, we performed 3 additional cycles with bortezomib + dexamethasone at weekly administration (days 1-8-15-22 for a 35 days cycle) and a peripheral blood stem cells harvest for autologous transplantation program.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article.</p>" "pdfFichero" => "P1-E574-S4714-A12108-EN.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:4 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437686" "palabras" => array:1 [ 0 => "Bortezomib" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437688" "palabras" => array:1 [ 0 => "Acute renal failure" ] ] 2 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437690" "palabras" => array:1 [ 0 => "Plasma cell dyscrasia" ] ] 3 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec437692" "palabras" => array:1 [ 0 => "High cut-off dialysers" ] ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hutchison CA, Heyne N, Airia P, Schindler R, Zickler D, Cook M, et Al. Immunoglobulin free light chain levels and recovery from myeloma kidney on treatment with chemotherapy and high cut-off haemodialysis. Nephrol Dial Transplant 2012;27:3823-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/22273664" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:1 [ "itemHostRev" => array:3 [ "pii" => "S1525861013005057" "estado" => "S300" "issn" => "15258610" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Hutchison CA, Cockwell P, Stringer S, Bradwell A, Cook M, Gertz MA, et al. Early reduction of serum-free light chains associates with renal recovery in myeloma kidney. J Am Soc Nephrol 2011;22:1129-36. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21511832" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003400000005/v0_201502091605/X201325141405443X/v0_201502091606/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003400000005/v0_201502091605/X201325141405443X/v0_201502091606/en/P1-E574-S4714-A12108-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X201325141405443X?idApp=UINPBA000064" ]
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