Response to the comment on 'IgM nephropathy in children: clinicopathologic analysis'
Luis F. Ariasa, M. Claudia Pradab, Catalia Vélez-Echeverric, Lina M. Serna-Higuitac, Ana K. Serrano-Gayubob, Carolina L. Ochoac, Juan J. Vanegas-Ruizc
a Departamento de Patología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia,
b Servicio de Nefrología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia,
c Servicio de Nefrología, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia,
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Arias, M. Claudia Prada, Catalia Vélez-Echeverri, Lina M. Serna-Higuita, Ana K. Serrano-Gayubo, Carolina L. Ochoa, Juan J. Vanegas-Ruiz" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Luis F." "apellidos" => "Arias" "email" => array:1 [ 0 => "lm.serna@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "M. Claudia" "apellidos" => "Prada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 2 => array:3 [ "nombre" => "Catalia" "apellidos" => "Vélez-Echeverri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 3 => array:3 [ "nombre" => "Lina M." "apellidos" => "Serna-Higuita" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 4 => array:3 [ "nombre" => "Ana K." "apellidos" => "Serrano-Gayubo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] 5 => array:3 [ "nombre" => "Carolina L." "apellidos" => "Ochoa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] 6 => array:3 [ "nombre" => "Juan J." "apellidos" => "Vanegas-Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Patología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Servicio de Nefrología, Facultad de Medicina, Universidad de Antioquia y Hospital Universitario San Vicente de Paúl, Medellín, Antioquia, Colombia, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] 2 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia, " "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "affc" ] ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara">We thank Dr. Mubarak for his interest in and comment on our article “IgM nephropathy in children: clinicopathologic analysis”<span class="elsevierStyleSup">1</span>. We agree with Dr. Mubarak that IgM nephropathy (IgMN) is a very controversial entity, with variable definitions in the different case series published. As in all series of glomerulopathy cases, the percentage frequency variability depends largely on the subjectivity of diagnosis in many cases, the characteristics of each study population and the denominator used to determine the percentage. We decided use all renal biopsies because it gives us an idea of the total frequency of cases and permit to compare with other glomerulopathies frequencies. In our series, 138 children were biopsied due to nephrotic syndrome, so IgMN percentage frequency in children with nephrotic syndrome was 9.4%. With respect minimum threshold of IgM positivity used for us in order to define IgM Nephropaty was “++”.</p><p class="elsevierStylePara">The evolution time in ours patients was 1 year until 21 years (diagnostic moment until last observation); but, we used the time between the first evaluation in this hospital and one year more like follow up.</p><p class="elsevierStylePara">Dr. Mubarak his appreciations about Table 1 is correct, we mistake this information because at moment of diagnosis, seven patients present hematuria and three hypertension. About laboratory information, ours creatine values are mg/dL and for proteinuria mg/m<span class="elsevierStyleSup">2</span>/hours, and for last, those patients were classified like cortico-resistant or cortico-dependent in the last evaluations that we found.</p><p class="elsevierStylePara">Thank you for his correction.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript.</p>" "pdfFichero" => "P1-E565-S4506-A12404-EN.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "<p class="elsevierStylePara">Reply to: Mubarak M.</p> <p class="elsevierStylePara">Comment on: Nefrologia 2014;34(1):xxx-xxx.</p> <p class="elsevierStylePara">Nefrologia 2013;33(4):532-8. PMID: 23897185 [PubMed - in process]</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Arias LF, Prada MC, Vélez-Echeverri C, Serna-Higuita LM, Serrano-Gayubo AK, Ochoa CL, et al. IgM nephropathy in children: clinicopathological analysis. Nefrologia 2013;33:532-8. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23897185" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003400000001/v0_201502091619/X2013251414053548/v0_201502091620/en/main.assets" "Apartado" => array:4 [ "identificador" => "35439" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Comments on published articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003400000001/v0_201502091619/X2013251414053548/v0_201502091620/en/P1-E565-S4506-A12404-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251414053548?idApp=UINPBA000064" ]
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