Treatment with megestrol acetate increases muscle mass in uraemic patients
El tratamiento con acetato de megestrol aumenta la masa muscular en el enfermo urémico
Read
9885
Timeswas read the article
2136
Total PDF
7749
Total HTML
Share statistics
array:21 [ "pii" => "X2013251413003080" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Feb.11819" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:425-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4703 "formatos" => array:3 [ "EPUB" => 318 "HTML" => 3786 "PDF" => 599 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699513003083" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2013.Feb.11819" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2013;33:425-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 23202 "formatos" => array:3 [ "EPUB" => 311 "HTML" => 22064 "PDF" => 827 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "El tratamiento con acetato de megestrol aumenta la masa muscular en el enfermo urémico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "425" "paginaFinal" => "426" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Treatment with megestrol acetate increases muscle mass in uraemic patients" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11819_19904_38534_es_11819_t1.jpg" "Alto" => 469 "Ancho" => 900 "Tamanyo" => 229990 ] ] "descripcion" => array:1 [ "es" => "Análisis de la composición corporal por BIA, antes y después del tratamiento con acetato de megestrol" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Milagros Fernández-Lucas, Sandra Elías, Gloria Ruiz-Roso, Martha Díaz, José L. Teruel-Briones, Carlos Quereda" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Milagros" "apellidos" => "Fernández-Lucas" ] 1 => array:2 [ "nombre" => "Sandra" "apellidos" => "Elías" ] 2 => array:2 [ "nombre" => "Gloria" "apellidos" => "Ruiz-Roso" ] 3 => array:2 [ "nombre" => "Martha" "apellidos" => "Díaz" ] 4 => array:2 [ "nombre" => "José L." "apellidos" => "Teruel-Briones" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Quereda" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251413003080" "doi" => "10.3265/Nefrologia.pre2013.Feb.11819" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413003080?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513003083?idApp=UINPBA000064" "url" => "/02116995/0000003300000003/v0_201502091323/X0211699513003083/v0_201502091323/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251413003072" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.Feb.11892" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:426-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3805 "formatos" => array:3 [ "EPUB" => 318 "HTML" => 2899 "PDF" => 588 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Effectiveness of haemodiafiltration with ultrafiltrate regeneration in renal failure due to multiple myeloma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "426" "paginaFinal" => "428" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia de la hemodiafiltración con regeneración del ultrafiltrado en la insuficiencia renal por mieloma múltiple" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Tab. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11892_16025_46821_en_11892_t1.jpg" "Alto" => 481 "Ancho" => 1434 "Tamanyo" => 129344 ] ] "descripcion" => array:1 [ "en" => "Reduction rates in blood" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Victoria Pendón-Ruiz de Mier, Raquel Ojeda-López, M. Antonia Álvarez de Lara-Sánchez, Alejandro Martín-Malo, Pedro Aljama-García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M. Victoria" "apellidos" => "Pendón-Ruiz de Mier" ] 1 => array:2 [ "nombre" => "Raquel" "apellidos" => "Ojeda-López" ] 2 => array:2 [ "nombre" => "M. Antonia" "apellidos" => "Álvarez de Lara-Sánchez" ] 3 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Martín-Malo" ] 4 => array:2 [ "nombre" => "Pedro" "apellidos" => "Aljama-García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513003075" "doi" => "10.3265/Nefrologia.pre2013.Feb.11892" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513003075?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413003072?idApp=UINPBA000064" "url" => "/20132514/0000003300000003/v0_201502091549/X2013251413003072/v0_201502091550/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251413003099" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2013.May.12102" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:424-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3648 "formatos" => array:3 [ "EPUB" => 300 "HTML" => 2728 "PDF" => 620 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Response to the Comment 'Are the aims of the K/DOQI guidelines for mineral metabolism disorders in patients with stage 3-5 chronic kidney disease unachievable or inadequate?'" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "424" "paginaFinal" => "425" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Elvira Fernández-Giráldez, Elvira Fernández Giráldez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Elvira" "apellidos" => "Fernández-Giráldez" ] 1 => array:2 [ "nombre" => "Elvira" "apellidos" => "Fernández Giráldez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513003091" "doi" => "10.3265/Nefrologia.pre2013.May.12102" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513003091?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413003099?idApp=UINPBA000064" "url" => "/20132514/0000003300000003/v0_201502091549/X2013251413003099/v0_201502091550/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Treatment with megestrol acetate increases muscle mass in uraemic patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "425" "paginaFinal" => "426" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Milagros Fernández-Lucas, Sandra Elías, Gloria Ruiz-Roso, Martha Díaz, José L. Teruel-Briones, Carlos Quereda" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Milagros" "apellidos" => "Fernández-Lucas" "email" => array:1 [ 0 => "mfernandez.hrc@salud.madrid.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Sandra" "apellidos" => "Elías" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "Gloria" "apellidos" => "Ruiz-Roso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "Martha" "apellidos" => "Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "nombre" => "José L." "apellidos" => "Teruel-Briones" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "nombre" => "Carlos" "apellidos" => "Quereda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital Universitario Ramón y Cajal, Madrid, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El tratamiento con acetato de megestrol aumenta la masa muscular en el enfermo urémico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11819_16025_46809_en_11819t1.jpg" "Alto" => 717 "Ancho" => 1434 "Tamanyo" => 230457 ] ] "descripcion" => array:1 [ "en" => "Analysis of body composition by BIA before and after treatment with megestrol acetate." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor:</span></p><p class="elsevierStylePara">Megestrol acetate is an appetite stimulant used in the treatment of uraemic patients’ anorexia. When administered in appropriate doses, it achieves an increase in weight and the improvement of other nutritional parameters without significant side effects.<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">The body compartment responsible for weight gain induced by megestrol acetate is a subject of controversy. Very few studies have examined this issue and the results are conflicting. While the work by Golebiewska et al. observed a tendency to retain hydrosaline,<span class="elsevierStyleSup">2</span> other authors observed increased fat mass<span class="elsevierStyleSup">3,4</span> and increased fat free mass.<span class="elsevierStyleSup">5</span></p><p class="elsevierStylePara">We had the opportunity to analyse body composition with electrical bioimpedance techniques in 9 patients who experienced significant weight gain after treatment with megestrol acetate.</p><p class="elsevierStylePara">Our patients are 4 males and 5 females, between 40 and 80 years of age. None had residual renal function and they were treated with three weekly sessions of haemodialysis. All received a daily dose of 160mg megestrol acetate.</p><p class="elsevierStylePara">The baseline electrical bioimpedance analysis was performed immediately before the start of treatment with megestrol acetate and it was repeated before withdrawal of the treatment when the patients were considered to have overcome a state of malnutrition and experienced a significant increase in weight. We used a single frequency bioimpedance model with the standard tetrapolar technique (EFG ElectroFluidGraph analyzer, Akern SRL, Florence, Italy). Bioimpedance studies were performed after the haemodialysis session, following a five minute rest period in the supine position, using a current of 300 microA a 50kHz.</p><p class="elsevierStylePara">The duration of treatment with megestrol acetate ranged between 2 and 12 months (6.5±3.8, mean ± standard deviation). The dose of dialysis did not change during this time period (Daurgidas unicompartmental Kt/V: baseline 1.48 end 1.50). After the treatment, patients experienced an increase in weight which varied between 2 and 9kg associated with an increase in the protein catabolic rate (1.25 compared with 0.97g/kg/day, <span class="elsevierStyleItalic">P</span><.05) , albumin concentration (3.9 compared with 3.50g/dl, <span class="elsevierStyleItalic">P</span><.05), serum creatinine (10.1 compared with 8.34mg/dl, <span class="elsevierStyleItalic">P</span><.05) and urea (198 compared with 175mg/dl, <span class="elsevierStyleItalic">P</span><.05), without there being variations in the concentration of phosphorus (4.9 compared with 4.8mg/dl) and the dialysis dose (Daurgidas spKt/V 1.47 compared with 1.49). Table 1 shows the body composition data provided by the bioimpedance analysis before and after treatment with megestrol acetate.</p><p class="elsevierStylePara">Treatment with megestrol acetate leads to a better distribution of total body water with increased intracellular water component. Increased intracellular water is consistent with the increase observed in total cell mass. There was an increase in muscle mass and a small increase, not statistically significant, in fat mass. This increase in muscle mass would explain the increase in creatinine concentration observed in our patients.</p><p class="elsevierStylePara">Our results correspond to those of a study performed on a group of patients selected due to having experienced a significant weight increase after the administration of megestrol acetate. We can conclude that in this group of patients the increase in weight is not due to hydrosaline retention but rather, it is produced at the expense of an increase in lean mass, both of the cellular and muscular component. This finding is very significant if we take into account the association described between the increase in muscle mass and the better survival rate of the uraemic patient.<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article.</p><p class="elsevierStylePara"><a href="grande/11819_16025_46809_en_11819t1.jpg" class="elsevierStyleCrossRefs"><img src="11819_16025_46809_en_11819t1.jpg" alt="Analysis of body composition by BIA before and after treatment with megestrol acetate."></img></a></p><p class="elsevierStylePara">Table 1. Analysis of body composition by BIA before and after treatment with megestrol acetate.</p>" "pdfFichero" => "P1-E550-S4090-A11819-EN.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11819_16025_46809_en_11819t1.jpg" "Alto" => 717 "Ancho" => 1434 "Tamanyo" => 230457 ] ] "descripcion" => array:1 [ "en" => "Analysis of body composition by BIA before and after treatment with megestrol acetate." ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003300000003/v0_201502091549/X2013251413003080/v0_201502091550/en/main.assets" "Apartado" => array:4 [ "identificador" => "35438" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief papers about basic research or clinical experiences" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000003/v0_201502091549/X2013251413003080/v0_201502091550/en/P1-E550-S4090-A11819-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413003080?idApp=UINPBA000064" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 8 | 18 |
| 2024 October | 76 | 30 | 106 |
| 2024 September | 117 | 30 | 147 |
| 2024 August | 94 | 45 | 139 |
| 2024 July | 85 | 23 | 108 |
| 2024 June | 91 | 45 | 136 |
| 2024 May | 81 | 36 | 117 |
| 2024 April | 49 | 27 | 76 |
| 2024 March | 62 | 30 | 92 |
| 2024 February | 63 | 29 | 92 |
| 2024 January | 51 | 27 | 78 |
| 2023 December | 54 | 27 | 81 |
| 2023 November | 61 | 29 | 90 |
| 2023 October | 75 | 37 | 112 |
| 2023 September | 72 | 41 | 113 |
| 2023 August | 73 | 22 | 95 |
| 2023 July | 98 | 25 | 123 |
| 2023 June | 104 | 20 | 124 |
| 2023 May | 91 | 33 | 124 |
| 2023 April | 65 | 30 | 95 |
| 2023 March | 67 | 15 | 82 |
| 2023 February | 52 | 16 | 68 |
| 2023 January | 63 | 13 | 76 |
| 2022 December | 68 | 27 | 95 |
| 2022 November | 58 | 35 | 93 |
| 2022 October | 65 | 31 | 96 |
| 2022 September | 72 | 23 | 95 |
| 2022 August | 65 | 34 | 99 |
| 2022 July | 58 | 39 | 97 |
| 2022 June | 63 | 24 | 87 |
| 2022 May | 80 | 34 | 114 |
| 2022 April | 57 | 51 | 108 |
| 2022 March | 79 | 47 | 126 |
| 2022 February | 65 | 34 | 99 |
| 2022 January | 70 | 31 | 101 |
| 2021 December | 53 | 38 | 91 |
| 2021 November | 46 | 29 | 75 |
| 2021 October | 82 | 39 | 121 |
| 2021 September | 59 | 32 | 91 |
| 2021 August | 77 | 37 | 114 |
| 2021 July | 75 | 32 | 107 |
| 2021 June | 58 | 14 | 72 |
| 2021 May | 83 | 30 | 113 |
| 2021 April | 186 | 48 | 234 |
| 2021 March | 104 | 31 | 135 |
| 2021 February | 56 | 18 | 74 |
| 2021 January | 75 | 14 | 89 |
| 2020 December | 64 | 17 | 81 |
| 2020 November | 49 | 13 | 62 |
| 2020 October | 39 | 10 | 49 |
| 2020 September | 49 | 6 | 55 |
| 2020 August | 61 | 9 | 70 |
| 2020 July | 60 | 8 | 68 |
| 2020 June | 54 | 20 | 74 |
| 2020 May | 54 | 11 | 65 |
| 2020 April | 61 | 13 | 74 |
| 2020 March | 45 | 10 | 55 |
| 2020 February | 53 | 19 | 72 |
| 2020 January | 71 | 15 | 86 |
| 2019 December | 59 | 16 | 75 |
| 2019 November | 45 | 19 | 64 |
| 2019 October | 39 | 6 | 45 |
| 2019 September | 37 | 13 | 50 |
| 2019 August | 36 | 14 | 50 |
| 2019 July | 62 | 20 | 82 |
| 2019 June | 38 | 11 | 49 |
| 2019 May | 55 | 11 | 66 |
| 2019 April | 76 | 35 | 111 |
| 2019 March | 55 | 15 | 70 |
| 2019 February | 50 | 22 | 72 |
| 2019 January | 39 | 13 | 52 |
| 2018 December | 139 | 35 | 174 |
| 2018 November | 97 | 23 | 120 |
| 2018 October | 113 | 14 | 127 |
| 2018 September | 77 | 10 | 87 |
| 2018 August | 71 | 24 | 95 |
| 2018 July | 46 | 13 | 59 |
| 2018 June | 53 | 15 | 68 |
| 2018 May | 56 | 18 | 74 |
| 2018 April | 49 | 4 | 53 |
| 2018 March | 57 | 8 | 65 |
| 2018 February | 54 | 9 | 63 |
| 2018 January | 55 | 5 | 60 |
| 2017 December | 62 | 13 | 75 |
| 2017 November | 48 | 15 | 63 |
| 2017 October | 47 | 13 | 60 |
| 2017 September | 53 | 15 | 68 |
| 2017 August | 44 | 12 | 56 |
| 2017 July | 47 | 16 | 63 |
| 2017 June | 39 | 7 | 46 |
| 2017 May | 39 | 7 | 46 |
| 2017 April | 37 | 13 | 50 |
| 2017 March | 15 | 6 | 21 |
| 2017 February | 25 | 16 | 41 |
| 2017 January | 32 | 19 | 51 |
| 2016 December | 38 | 6 | 44 |
| 2016 November | 54 | 11 | 65 |
| 2016 October | 68 | 7 | 75 |
| 2016 September | 71 | 3 | 74 |
| 2016 August | 131 | 7 | 138 |
| 2016 July | 175 | 16 | 191 |
| 2016 June | 117 | 0 | 117 |
| 2016 May | 137 | 0 | 137 |
| 2016 April | 97 | 0 | 97 |
| 2016 March | 67 | 0 | 67 |
| 2016 February | 104 | 0 | 104 |
| 2016 January | 86 | 0 | 86 |
| 2015 December | 136 | 0 | 136 |
| 2015 November | 85 | 0 | 85 |
| 2015 October | 81 | 0 | 81 |
| 2015 September | 62 | 0 | 62 |
| 2015 August | 61 | 0 | 61 |
| 2015 July | 70 | 0 | 70 |
| 2015 June | 34 | 0 | 34 |
| 2015 May | 56 | 0 | 56 |
| 2015 April | 5 | 0 | 5 |
Show all
