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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Content</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#58;</span></p><p class="elsevierStylePara">Sarcoidosis may induce interstitial granulomatous nephritis &#40;15&#37;-40&#37;&#41;&#44; abnormalities in the calcium-phosphorus balance &#40;hypercalciuria 50&#37;&#44; hypercalcaemia 10&#37;&#41;&#44; distal tubulopathy with diabetes insipidus&#44; obstructive uropathy and membranous glomerulonephritis &#40;GN&#41;&#59; to a lesser extent membranoproliferative&#44; mesangial or focal segmental glomerulonephritis &#40;FSGN&#41;&#46; We report a relevant case&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Our patient is a 35-year-old Moroccan male&#44; with no previous illnesses&#46; He sought consultation due to proteinuria&#46; Physical examination without findings&#46; Blood test plasma creatinine 1&#46;1mg&#47;dl&#44; creatinine clearance 97ml&#47;min&#47;1&#46;73m<span class="elsevierStyleSup">2</span>&#44; non-selective glomerular proteinuria 3&#46;67g&#47;d&#46; Albumin 3&#46;9mg&#47;dl&#44; cholesterol 239 mg&#47;dl&#44; urine analysis with proteinuria 300mg&#47;dl and microhaematuria&#46; Red blood cell sedimentation rate 8mmHg 1<span class="elsevierStyleSup">st</span> hour&#44; viral serology&#44; tumour markers&#44; thyroid profile&#44; immunology&#44; protein electrophoresis&#44; serum and urine protein immunoelectrophoresis&#44; hepatopancreatic profile and chest radiograph normal&#46; Renal ultrasound with kidneys of 110 and 114mm and conserved cortex&#46; Renal biopsy &#40;Figure 1&#41; showing 7 glomeruli&#58; 3 sclerotic&#44; 4 with hyaline segmental lesions&#44; cellular proliferation and synechia&#44; mesangial expansion&#44; fibrosis and grade I&#47;III tubular atrophy&#44; lymphoplasmacytic interstitial infiltrates&#46; Arteries and arterioles without lesions&#46; In the direct immunofluorescence&#58; IgM and C&#39;3 deposits in the mesangium&#46; Electron microscopy &#40;EM&#41; was not conducted&#46; When he was diagnosed with FSGN&#44; he was treated with angiotensin converting enzyme inhibitors &#40;ACEI&#41;&#46; At 3 months proteinuria had decreased to 1g&#47;d&#46; Dual blockade was started &#40;ACEI and angiotensin II receptor antagonists&#41;&#46; At 6 months&#44; the glomerular filtration rate &#40;GFR&#41; remained stable and proteinuria was at 0&#46;5-0&#46;7g&#47;day&#46; At 12 months&#44; he started to experience abdominal pain&#44; diarrhoea&#44; vomiting and increased amylase&#46; Computerised tomography &#40;CT&#41; of the chest and abdomen was performed&#44; revealing lateral cervical&#44; axillary&#44; hilar&#44; mediastinal and liver hilar lymphadenopathy and centrilobular nodules&#46; Bone series and thyroid profile normal&#44; serology for Epstein-Barr virus&#44; cytomegalovirus&#44; rubella&#44; brucellosis&#44; syphilis and toxoplasma and tumour markers negative&#44; angiotensin converting enzyme 46&#46;3U&#47;l &#40;range 20-70&#41;&#44; 25OH vitamin D<span class="elsevierStyleInf">3</span> 15&#46;3ng&#47;ml&#44; 1-25 di&#40;OH&#41; vitamin D<span class="elsevierStyleInf">3</span> 45&#46;4ng&#47;ml &#40;range 18-78&#41;&#44; intact parathyroid hormone 30pg&#47;ml &#40;range 15-60&#41;&#44; urinary calcium 40mg&#47;d&#44; phosphaturia 732mg&#47;d&#44; calcaemia 10mg&#47;dl&#44; phosphataemia 3&#46;0mg&#47;dl&#46; Bronchoscopy with bronchoalveolar lavage and needle aspiration of mediastinal lymph node cellularity showing macrophage predominance&#46; Transbronchial biopsy suggestive of non-necrotising granulomatous inflammatory process&#44; accumulations of histiocytes and giant multinucleated cells&#46; Zhiel-Neelsen and Lowenstein culture negative&#46; Bronchoalveolar lavage with lymphocyte predominant cellularity and increased CD4&#47;CD8 ratio&#46; With sarcoidosis being diagnosed&#44; treatment with prednisone began and was maintained for 12 months&#46; He evolved favourably&#46; CT at 6 months revealed disappearance of mediastinal lymphadenopathy and parenchymal involvement&#46; After 24 months&#44; the GFR remained stable&#44; proteinuria of 0&#46;5g&#47;d was maintained and there were no relevant incidents&#46;</p><p class="elsevierStylePara">The association between sarcoidosis and FSGN dates back to 1978&#46;<span class="elsevierStyleSup">1</span> Only 7 cases are described in PubMed<span class="elsevierStyleSup">1-7 </span>&#40;Table 1&#41;&#46; They affect 50&#37; of males&#44; with a mean age of 37&#46;8 years&#46; In all&#44; proteinuria was in the nephrotic range&#46; Renal failure only occurred in 2 cases and both progressed to the end stage&#44; requiring haemodialysis and subsequently a kidney transplant&#46; In all cases&#44; the response to pulmonary symptoms was good&#44; however this was not the case for the evolution of proteinuria&#44; which remained in a nephrotic range in 4&#44; decreased quantitatively in 2 and was resolved in 2 others&#46; GN diagnosis after sarcoidosis diagnosis occurred in 50&#37; of cases&#46; In all biopsies there was glomerular sclerosis&#44; focal segmental lesions and hyalinosis&#46; There was only tubular atrophy in 5&#44; interstitial inflammatory infiltrates in 4&#44; synechiae and increased mesangial matrix in 3&#44; periglomerular fibrosis in 2 and negative direct immunofluorescence in 2 with deposits of IgG in 1&#44; C&#39;3 in 4&#44; IgM in 4 and C&#39;1q in 1 case located in the mesangium and subendothelium&#46; EM was only performed in 2 cases&#44; both revealed podocyte fusion and lack of immune complex&#46; In just one<span class="elsevierStyleSup">2</span> of the cases described&#44; renal interstitial granulomas were found with 12&#46;5&#37; involvement&#44; lower than that reported in literature &#40;15-40&#37;&#41;&#46; The good evolution of GFR and proteinuria with conservative treatment was notable and it did not improve by adding corticosteroids for their lung disease&#46;</p><p class="elsevierStylePara">This association can be paradoxical&#46; In sarcoidosis&#44; there is an immune imbalance with upregulation of the TH1 pathway&#44; and in FSGN upregulation of the TH2 pathway&#46;<span class="elsevierStyleSup">8&#44;9</span> However&#44; in late stages TH17 predominates&#44; inducing secretion of interleukin 17<span class="elsevierStyleSup">10</span> favouring the development of fibrosis&#46; Cardiotrophin-like cytokine 1&#44; involved in the development of FSGN&#44; is increased in pathway TH17&#44;<span class="elsevierStyleSup">11-13</span> which may be the link between both&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">We present the case of a patient with FSGN onset who that year was diagnosed with sarcoidosis&#44; with good pulmonary and renal evolution on treatment with corticosteroids and blockade of the renin&#8211;angiotensin-aldosterone system&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11753&#95;16025&#95;46874&#95;en&#95;11753&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11753_16025_46874_en_11753_t1.jpg" alt="Summary of published cases of focal segmental glomerulonephritis associated with sarcoidosis"></img></a></p><p class="elsevierStylePara">Table 1&#46; Summary of published cases of focal segmental glomerulonephritis associated with sarcoidosis</p><p class="elsevierStylePara"><a href="grande&#47;11753&#95;16025&#95;46875&#95;en&#95;11753&#95;f1&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11753_16025_46875_en_11753_f1_copy1.jpg" alt="Focal segmental glomerulosclerosis"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Focal segmental glomerulosclerosis</p>"
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Focal segmental glomerulonephritis in patients with pulmonary sarcoidosis
Glomerulonefritis focal y segmentaria en paciente con sarcoidosis pulmonar
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non-selective glomerular proteinuria 3&#46;67g&#47;d&#46; Albumin 3&#46;9mg&#47;dl&#44; cholesterol 239 mg&#47;dl&#44; urine analysis with proteinuria 300mg&#47;dl and microhaematuria&#46; Red blood cell sedimentation rate 8mmHg 1<span class="elsevierStyleSup">st</span> hour&#44; viral serology&#44; tumour markers&#44; thyroid profile&#44; immunology&#44; protein electrophoresis&#44; serum and urine protein immunoelectrophoresis&#44; hepatopancreatic profile and chest radiograph normal&#46; Renal ultrasound with kidneys of 110 and 114mm and conserved cortex&#46; Renal biopsy &#40;Figure 1&#41; showing 7 glomeruli&#58; 3 sclerotic&#44; 4 with hyaline segmental lesions&#44; cellular proliferation and synechia&#44; mesangial expansion&#44; fibrosis and grade I&#47;III tubular atrophy&#44; lymphoplasmacytic interstitial infiltrates&#46; Arteries and arterioles without lesions&#46; In the direct immunofluorescence&#58; IgM and C&#39;3 deposits in the mesangium&#46; Electron microscopy &#40;EM&#41; was not conducted&#46; When he was diagnosed with FSGN&#44; he was treated with angiotensin converting enzyme inhibitors &#40;ACEI&#41;&#46; At 3 months proteinuria had decreased to 1g&#47;d&#46; Dual blockade was started &#40;ACEI and angiotensin II receptor antagonists&#41;&#46; At 6 months&#44; the glomerular filtration rate &#40;GFR&#41; remained stable and proteinuria was at 0&#46;5-0&#46;7g&#47;day&#46; At 12 months&#44; he started to experience abdominal pain&#44; diarrhoea&#44; vomiting and increased amylase&#46; Computerised tomography &#40;CT&#41; of the chest and abdomen was performed&#44; revealing lateral cervical&#44; axillary&#44; hilar&#44; mediastinal and liver hilar lymphadenopathy and centrilobular nodules&#46; Bone series and thyroid profile normal&#44; serology for Epstein-Barr virus&#44; cytomegalovirus&#44; rubella&#44; brucellosis&#44; syphilis and toxoplasma and tumour markers negative&#44; angiotensin converting enzyme 46&#46;3U&#47;l &#40;range 20-70&#41;&#44; 25OH vitamin D<span class="elsevierStyleInf">3</span> 15&#46;3ng&#47;ml&#44; 1-25 di&#40;OH&#41; vitamin D<span class="elsevierStyleInf">3</span> 45&#46;4ng&#47;ml &#40;range 18-78&#41;&#44; intact parathyroid hormone 30pg&#47;ml &#40;range 15-60&#41;&#44; urinary calcium 40mg&#47;d&#44; phosphaturia 732mg&#47;d&#44; calcaemia 10mg&#47;dl&#44; phosphataemia 3&#46;0mg&#47;dl&#46; Bronchoscopy with bronchoalveolar lavage and needle aspiration of mediastinal lymph node cellularity showing macrophage predominance&#46; Transbronchial biopsy suggestive of non-necrotising granulomatous inflammatory process&#44; accumulations of histiocytes and giant multinucleated cells&#46; Zhiel-Neelsen and Lowenstein culture negative&#46; Bronchoalveolar lavage with lymphocyte predominant cellularity and increased CD4&#47;CD8 ratio&#46; With sarcoidosis being diagnosed&#44; treatment with prednisone began and was maintained for 12 months&#46; He evolved favourably&#46; CT at 6 months revealed disappearance of mediastinal lymphadenopathy and parenchymal involvement&#46; After 24 months&#44; the GFR remained stable&#44; proteinuria of 0&#46;5g&#47;d was maintained and there were no relevant incidents&#46;</p><p class="elsevierStylePara">The association between sarcoidosis and FSGN dates back to 1978&#46;<span class="elsevierStyleSup">1</span> Only 7 cases are described in PubMed<span class="elsevierStyleSup">1-7 </span>&#40;Table 1&#41;&#46; They affect 50&#37; of males&#44; with a mean age of 37&#46;8 years&#46; In all&#44; proteinuria was in the nephrotic range&#46; Renal failure only occurred in 2 cases and both progressed to the end stage&#44; requiring haemodialysis and subsequently a kidney transplant&#46; In all cases&#44; the response to pulmonary symptoms was good&#44; however this was not the case for the evolution of proteinuria&#44; which remained in a nephrotic range in 4&#44; decreased quantitatively in 2 and was resolved in 2 others&#46; GN diagnosis after sarcoidosis diagnosis occurred in 50&#37; of cases&#46; In all biopsies there was glomerular sclerosis&#44; focal segmental lesions and hyalinosis&#46; There was only tubular atrophy in 5&#44; interstitial inflammatory infiltrates in 4&#44; synechiae and increased mesangial matrix in 3&#44; periglomerular fibrosis in 2 and negative direct immunofluorescence in 2 with deposits of IgG in 1&#44; C&#39;3 in 4&#44; IgM in 4 and C&#39;1q in 1 case located in the mesangium and subendothelium&#46; EM was only performed in 2 cases&#44; both revealed podocyte fusion and lack of immune complex&#46; In just one<span class="elsevierStyleSup">2</span> of the cases described&#44; renal interstitial granulomas were found with 12&#46;5&#37; involvement&#44; lower than that reported in literature &#40;15-40&#37;&#41;&#46; The good evolution of GFR and proteinuria with conservative treatment was notable and it did not improve by adding corticosteroids for their lung disease&#46;</p><p class="elsevierStylePara">This association can be paradoxical&#46; In sarcoidosis&#44; there is an immune imbalance with upregulation of the TH1 pathway&#44; and in FSGN upregulation of the TH2 pathway&#46;<span class="elsevierStyleSup">8&#44;9</span> However&#44; in late stages TH17 predominates&#44; inducing secretion of interleukin 17<span class="elsevierStyleSup">10</span> favouring the development of fibrosis&#46; Cardiotrophin-like cytokine 1&#44; involved in the development of FSGN&#44; is increased in pathway TH17&#44;<span class="elsevierStyleSup">11-13</span> which may be the link between both&#46;<span class="elsevierStyleSup">11</span></p><p class="elsevierStylePara">We present the case of a patient with FSGN onset who that year was diagnosed with sarcoidosis&#44; with good pulmonary and renal evolution on treatment with corticosteroids and blockade of the renin&#8211;angiotensin-aldosterone system&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11753&#95;16025&#95;46874&#95;en&#95;11753&#95;t1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11753_16025_46874_en_11753_t1.jpg" alt="Summary of published cases of focal segmental glomerulonephritis associated with sarcoidosis"></img></a></p><p class="elsevierStylePara">Table 1&#46; Summary of published cases of focal segmental glomerulonephritis associated with sarcoidosis</p><p class="elsevierStylePara"><a href="grande&#47;11753&#95;16025&#95;46875&#95;en&#95;11753&#95;f1&#95;copy1&#46;jpg" class="elsevierStyleCrossRefs"><img src="11753_16025_46875_en_11753_f1_copy1.jpg" alt="Focal segmental glomerulosclerosis"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Focal segmental glomerulosclerosis</p>"
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