array:21 [
  "pii" => "X2013251413002450"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2013;33:147-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4211
    "formatos" => array:3 [
      "EPUB" => 327
      "HTML" => 3213
      "PDF" => 671
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:17 [
      "pii" => "X0211699513002453"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
      "estado" => "S300"
      "fechaPublicacion" => "2013-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2013;33:147-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6325
        "formatos" => array:3 [
          "EPUB" => 355
          "HTML" => 5228
          "PDF" => 742
        ]
      ]
      "en" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "147"
            "paginaFinal" => "148"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Zafer Ercan, Mehmet E. Demir, Turgay Ulas, Muharrem Ingec, Mehmet Horoz"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Zafer"
                "apellidos" => "Ercan"
              ]
              1 => array:2 [
                "nombre" => "Mehmet E."
                "apellidos" => "Demir"
              ]
              2 => array:2 [
                "nombre" => "Turgay"
                "apellidos" => "Ulas"
              ]
              3 => array:2 [
                "nombre" => "Muharrem"
                "apellidos" => "Ingec"
              ]
              4 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Horoz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251413002450"
          "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002450?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002453?idApp=UINPBA000064"
      "url" => "/02116995/0000003300000001/v0_201502091331/X0211699513002453/v0_201502091334/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251413002442"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jun.11557"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2013;33:148-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5243
      "formatos" => array:3 [
        "EPUB" => 339
        "HTML" => 4126
        "PDF" => 778
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Adverse reaction to intravenous iron: hypersensitivity or secondary side effect?"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "148"
          "paginaFinal" => "149"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reacción adversa por la administración intravenosa de hierro: ¿hipersensibilidad o efecto secundario?"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana E. Sirvent-Pedreño, Ricardo Enríquez-Ascarza, M. Dolores Redondo-Pachón, Isabel Millán-del Valle, César González-Martinez, Francisco Amorós-Amorós"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Ana E."
              "apellidos" => "Sirvent-Pedreño"
            ]
            1 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Enríquez-Ascarza"
            ]
            2 => array:2 [
              "nombre" => "M. Dolores"
              "apellidos" => "Redondo-Pachón"
            ]
            3 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Millán-del Valle"
            ]
            4 => array:2 [
              "nombre" => "César"
              "apellidos" => "González-Martinez"
            ]
            5 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Amorós-Amorós"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699513002445"
        "doi" => "10.3265/Nefrologia.pre2012.Jun.11557"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002445?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002442?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002442/v0_201502091556/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251413002469"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jun.11512"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2013;33:146-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4728
      "formatos" => array:3 [
        "EPUB" => 331
        "HTML" => 3730
        "PDF" => 667
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Mycophenolate mofetil induced severe, life threatening lower gastrointestinal bleeding - Case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "146"
          "paginaFinal" => "147"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11512_16025_30726_en_f111512.jpg"
              "Alto" => 493
              "Ancho" => 652
              "Tamanyo" => 72455
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Goran Hauser, Ivan Bubic, Vera Vlahovic-Palcevski, Josip Spanjol, Davor Stimac"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Goran"
              "apellidos" => "Hauser"
            ]
            1 => array:2 [
              "nombre" => "Ivan"
              "apellidos" => "Bubic"
            ]
            2 => array:2 [
              "nombre" => "Vera"
              "apellidos" => "Vlahovic-Palcevski"
            ]
            3 => array:2 [
              "nombre" => "Josip"
              "apellidos" => "Spanjol"
            ]
            4 => array:2 [
              "nombre" => "Davor"
              "apellidos" => "Stimac"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X0211699513002461"
        "doi" => "10.3265/Nefrologia.pre2012.Jun.11512"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002461?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002469?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002469/v0_201502091556/en/main.assets"
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "147"
        "paginaFinal" => "148"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Zafer Ercan, Mehmet E. Demir, Turgay Ulas, Muharrem Ingec, Mehmet Horoz"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "Zafer"
            "apellidos" => "Ercan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Mehmet E&#46;"
            "apellidos" => "Demir"
            "email" => array:1 [
              0 => "demirmehmetemin&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Turgay"
            "apellidos" => "Ulas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Muharrem"
            "apellidos" => "Ingec"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mehmet"
            "apellidos" => "Horoz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Department of Nephrology, Yildirim Beyazid Training and Research Hospital, Ankara,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Department of Nephrology, Harran University, School of Medicine, Sanliurfa,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "Department of Internal Medicine, Harran University, School of Medicine, Sanliurfa,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">Imerslund-Grasbeck syndrome &#40;IGS&#41; is a rare autosomal recessive disorder characterized by megaloblastic anemia due to selective vitamin B<span class="elsevierStyleInf">12</span> malabsorption and asymptomatic proteinuria&#46;<span class="elsevierStyleSup">1</span> IGS occurs in the first 1-2 years of the life and megalablostic anemia is responsive to parenteral vitamin B<span class="elsevierStyleInf">12</span> treatment&#46;<span class="elsevierStyleSup">2</span> It is thought that proteinuria is benign in IGS&#59; however&#44; there is no sufficient number of follow-up series in IGS&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">A 22-year-old woman had been referred to our pediatric outpatient clinic with the complaints of pale skin&#44; loss of appetite&#44; ataxia and diarrhea-constipation periods when she was 2-year-old&#46; The clinical examination and laboratory studies revealed pallor of conjunctiva&#44; megaloblastic anemia with vitamin B12 deficiency &#40;serum vitamin B<span class="elsevierStyleInf">12</span> level &#60;150pg&#47;ml&#44; hemoglobin&#58; 6&#46;5g&#47;dl&#44; MCV&#58; 104fl and peripheral blood smear with hypersegmented neutrophils&#41; and mild proteinuria &#40;less than 0&#46;5g&#47;day&#41; with absence of kidney function abnormality&#46; Two renal biopsies were performed because of persistent proteinuria&#44; however&#44; there was no remarkable histologically changes&#46; She was diagnosed with IGS in the light of this clinical picture&#46; Anemia and neurological symptoms were improved with vitamin B12 therapy in the next few weeks&#46; Mild proteinuria remains persist with normal kidney function and she is being still followed-up with periodically for proteinuria&#46;</p><p class="elsevierStylePara">IGS was firstly described in 1960 by Olga Imerslund and more than 300 cases have been published to date&#46; In IGS&#44; vitamin B<span class="elsevierStyleInf">12</span> is completely abolished and if untreated with parenteral therapy the disease is fatal&#46; A recent study revealed a biallelic mutation either in cubulin or amnions less genes cause IGS&#46;<span class="elsevierStyleSup">3</span> Both proteins act as a receptor for intrinsic factor-vitamin B<span class="elsevierStyleInf">12</span> complexes as well as cubulin is an albumin binding protein important for renal tubular albumine reabsorption&#46;<span class="elsevierStyleSup">4</span> Because of absence of glomerular damage in kidney biopsies progressive kidney disease is not usual&#46; Broch et al enrolled 14 patients to a long term follow-up study and exhibited no deterioration in kidney function&#46;<span class="elsevierStyleSup">5</span> Limited numbers of cases have been observed almost 50 years and renal prognosis is excellent&#46; We aimed to announce our case with IGS who has a good renal prognosis over 20 years follow-up&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest<br></br></span>&#160;<br></br>The authors declare that there is no conflict of interest associated with this manuscript&#46;</p>"
    "pdfFichero" => "P1-E547-S3873-A11661-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Imerslund O. Idiopathic chronic megaloblastic anemia in children. Acta Paediatr Suppl 1960;49(Suppl 119):1-115. <a href="http://www.ncbi.nlm.nih.gov/pubmed/13852753" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bonfin C, Strapasson E, Dellê LA, Malvezzi M, Moreira VA, Netto AG, et al. [Imerslund-Gräsbeck syndrome: report of two cases]. J Pediatr (Rio J) 1999;75(6):477-80."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Fyfe JC, Madsen M, Højrup P, Christensen EI, Tanner SM, de la Chapelle A, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 2004;103(5):1573-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14576052" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000;105(10):1353-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10811843" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Broch H, Imerslund O, Monn E, Hovig T, Seip M. Imerslund-Gräsbeck\u{A0}anemia. A\u{A0}long-term follow-up study. Acta Paediatr Scand 1984;73(2):248-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6741523" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002450/v0_201502091556/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000001/v0_201502091555/X2013251413002450/v0_201502091556/en/P1-E547-S3873-A11661-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002450?idApp=UINPBA000064"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria
Zafer Ercana, Mehmet E. Demirb, Turgay Ulasc, Muharrem Ingecc, Mehmet Horozb
a Department of Nephrology, Yildirim Beyazid Training and Research Hospital, Ankara, Turkey,
b Department of Nephrology, Harran University, School of Medicine, Sanliurfa, Turkey,
c Department of Internal Medicine, Harran University, School of Medicine, Sanliurfa, Turkey,
Read
7960
Times
was read the article
2319
Total PDF
5641
Total HTML
Share statistics
 array:21 [
  "pii" => "X2013251413002450"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
  "estado" => "S300"
  "fechaPublicacion" => "2013-01-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:147-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 4211
    "formatos" => array:3 [
      "EPUB" => 327
      "HTML" => 3213
      "PDF" => 671
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:17 [
      "pii" => "X0211699513002453"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
      "estado" => "S300"
      "fechaPublicacion" => "2013-01-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2013;33:147-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 6325
        "formatos" => array:3 [
          "EPUB" => 355
          "HTML" => 5228
          "PDF" => 742
        ]
      ]
      "en" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "147"
            "paginaFinal" => "148"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Zafer Ercan, Mehmet E&#46; Demir, Turgay Ulas, Muharrem Ingec, Mehmet Horoz"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Zafer"
                "apellidos" => "Ercan"
              ]
              1 => array:2 [
                "nombre" => "Mehmet E&#46;"
                "apellidos" => "Demir"
              ]
              2 => array:2 [
                "nombre" => "Turgay"
                "apellidos" => "Ulas"
              ]
              3 => array:2 [
                "nombre" => "Muharrem"
                "apellidos" => "Ingec"
              ]
              4 => array:2 [
                "nombre" => "Mehmet"
                "apellidos" => "Horoz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251413002450"
          "doi" => "10.3265/Nefrologia.pre2012.Aug.11661"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002450?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002453?idApp=UINPBA000064"
      "url" => "/02116995/0000003300000001/v0_201502091331/X0211699513002453/v0_201502091334/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251413002442"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jun.11557"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:148-9"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 5243
      "formatos" => array:3 [
        "EPUB" => 339
        "HTML" => 4126
        "PDF" => 778
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Adverse reaction to intravenous iron&#58; hypersensitivity or secondary side effect&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "148"
          "paginaFinal" => "149"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Reacci&#243;n adversa por la administraci&#243;n intravenosa de hierro&#58; &#191;hipersensibilidad o efecto secundario&#63;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana E&#46; Sirvent-Pedre&#241;o, Ricardo Enr&#237;quez-Ascarza, M&#46; Dolores Redondo-Pach&#243;n, Isabel Mill&#225;n-del Valle, C&#233;sar Gonz&#225;lez-Martinez, Francisco Amor&#243;s-Amor&#243;s"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Ana E&#46;"
              "apellidos" => "Sirvent-Pedre&#241;o"
            ]
            1 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Enr&#237;quez-Ascarza"
            ]
            2 => array:2 [
              "nombre" => "M&#46; Dolores"
              "apellidos" => "Redondo-Pach&#243;n"
            ]
            3 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Mill&#225;n-del Valle"
            ]
            4 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Gonz&#225;lez-Martinez"
            ]
            5 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Amor&#243;s-Amor&#243;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699513002445"
        "doi" => "10.3265/Nefrologia.pre2012.Jun.11557"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002445?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002442?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002442/v0_201502091556/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251413002469"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jun.11512"
    "estado" => "S300"
    "fechaPublicacion" => "2013-01-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia &#40;English Version&#41;. 2013;33:146-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4728
      "formatos" => array:3 [
        "EPUB" => 331
        "HTML" => 3730
        "PDF" => 667
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Mycophenolate mofetil induced severe&#44; life threatening lower gastrointestinal bleeding - Case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "146"
          "paginaFinal" => "147"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier Espa&#241;a"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11512_16025_30726_en_f111512.jpg"
              "Alto" => 493
              "Ancho" => 652
              "Tamanyo" => 72455
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Goran Hauser, Ivan Bubic, Vera Vlahovic-Palcevski, Josip Spanjol, Davor Stimac"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Goran"
              "apellidos" => "Hauser"
            ]
            1 => array:2 [
              "nombre" => "Ivan"
              "apellidos" => "Bubic"
            ]
            2 => array:2 [
              "nombre" => "Vera"
              "apellidos" => "Vlahovic-Palcevski"
            ]
            3 => array:2 [
              "nombre" => "Josip"
              "apellidos" => "Spanjol"
            ]
            4 => array:2 [
              "nombre" => "Davor"
              "apellidos" => "Stimac"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "X0211699513002461"
        "doi" => "10.3265/Nefrologia.pre2012.Jun.11512"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002461?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002469?idApp=UINPBA000064"
    "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002469/v0_201502091556/en/main.assets"
  ]
  "en" => array:9 [
    "idiomaDefecto" => true
    "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "147"
        "paginaFinal" => "148"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Zafer Ercan, Mehmet E&#46; Demir, Turgay Ulas, Muharrem Ingec, Mehmet Horoz"
        "autores" => array:5 [
          0 => array:3 [
            "nombre" => "Zafer"
            "apellidos" => "Ercan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Mehmet E&#46;"
            "apellidos" => "Demir"
            "email" => array:1 [
              0 => "demirmehmetemin&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Turgay"
            "apellidos" => "Ulas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Muharrem"
            "apellidos" => "Ingec"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "affc"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mehmet"
            "apellidos" => "Horoz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "affb"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Department of Nephrology, Yildirim Beyazid Training and Research Hospital, Ankara,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
          1 => array:3 [
            "entidad" => "Department of Nephrology, Harran University, School of Medicine, Sanliurfa,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "affb"
          ]
          2 => array:3 [
            "entidad" => "Department of Internal Medicine, Harran University, School of Medicine, Sanliurfa,  Turkey, "
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "affc"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor&#44;</span></p><p class="elsevierStylePara">Imerslund-Grasbeck syndrome &#40;IGS&#41; is a rare autosomal recessive disorder characterized by megaloblastic anemia due to selective vitamin B<span class="elsevierStyleInf">12</span> malabsorption and asymptomatic proteinuria&#46;<span class="elsevierStyleSup">1</span> IGS occurs in the first 1-2 years of the life and megalablostic anemia is responsive to parenteral vitamin B<span class="elsevierStyleInf">12</span> treatment&#46;<span class="elsevierStyleSup">2</span> It is thought that proteinuria is benign in IGS&#59; however&#44; there is no sufficient number of follow-up series in IGS&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">A 22-year-old woman had been referred to our pediatric outpatient clinic with the complaints of pale skin&#44; loss of appetite&#44; ataxia and diarrhea-constipation periods when she was 2-year-old&#46; The clinical examination and laboratory studies revealed pallor of conjunctiva&#44; megaloblastic anemia with vitamin B12 deficiency &#40;serum vitamin B<span class="elsevierStyleInf">12</span> level &#60;150pg&#47;ml&#44; hemoglobin&#58; 6&#46;5g&#47;dl&#44; MCV&#58; 104fl and peripheral blood smear with hypersegmented neutrophils&#41; and mild proteinuria &#40;less than 0&#46;5g&#47;day&#41; with absence of kidney function abnormality&#46; Two renal biopsies were performed because of persistent proteinuria&#44; however&#44; there was no remarkable histologically changes&#46; She was diagnosed with IGS in the light of this clinical picture&#46; Anemia and neurological symptoms were improved with vitamin B12 therapy in the next few weeks&#46; Mild proteinuria remains persist with normal kidney function and she is being still followed-up with periodically for proteinuria&#46;</p><p class="elsevierStylePara">IGS was firstly described in 1960 by Olga Imerslund and more than 300 cases have been published to date&#46; In IGS&#44; vitamin B<span class="elsevierStyleInf">12</span> is completely abolished and if untreated with parenteral therapy the disease is fatal&#46; A recent study revealed a biallelic mutation either in cubulin or amnions less genes cause IGS&#46;<span class="elsevierStyleSup">3</span> Both proteins act as a receptor for intrinsic factor-vitamin B<span class="elsevierStyleInf">12</span> complexes as well as cubulin is an albumin binding protein important for renal tubular albumine reabsorption&#46;<span class="elsevierStyleSup">4</span> Because of absence of glomerular damage in kidney biopsies progressive kidney disease is not usual&#46; Broch et al enrolled 14 patients to a long term follow-up study and exhibited no deterioration in kidney function&#46;<span class="elsevierStyleSup">5</span> Limited numbers of cases have been observed almost 50 years and renal prognosis is excellent&#46; We aimed to announce our case with IGS who has a good renal prognosis over 20 years follow-up&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflict of interest<br></br></span>&#160;<br></br>The authors declare that there is no conflict of interest associated with this manuscript&#46;</p>"
    "pdfFichero" => "P1-E547-S3873-A11661-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Imerslund O. Idiopathic chronic megaloblastic anemia in children. Acta Paediatr Suppl 1960;49(Suppl 119):1-115. <a href="http://www.ncbi.nlm.nih.gov/pubmed/13852753" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Bonfin C, Strapasson E, Dellê LA, Malvezzi M, Moreira VA, Netto AG, et al. [Imerslund-Gräsbeck syndrome: report of two cases]. J Pediatr (Rio J) 1999;75(6):477-80."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Fyfe JC, Madsen M, Højrup P, Christensen EI, Tanner SM, de la Chapelle A, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood 2004;103(5):1573-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/14576052" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Birn H, Fyfe JC, Jacobsen C, Mounier F, Verroust PJ, Orskov H, et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000;105(10):1353-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10811843" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Broch H, Imerslund O, Monn E, Hovig T, Seip M. Imerslund-Gräsbeck\u{A0}anemia. A\u{A0}long-term follow-up study. Acta Paediatr Scand 1984;73(2):248-53. <a href="http://www.ncbi.nlm.nih.gov/pubmed/6741523" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "\u{A0}"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002450/v0_201502091556/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000001/v0_201502091555/X2013251413002450/v0_201502091556/en/P1-E547-S3873-A11661-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002450?idApp=UINPBA000064"
]
Article information
ISSN: 20132514
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 11 17
2024 October 39 35 74
2024 September 52 35 87
2024 August 57 60 117
2024 July 32 29 61
2024 June 63 32 95
2024 May 63 29 92
2024 April 61 30 91
2024 March 42 28 70
2024 February 48 36 84
2024 January 51 22 73
2023 December 59 29 88
2023 November 36 29 65
2023 October 65 26 91
2023 September 89 30 119
2023 August 27 25 52
2023 July 61 18 79
2023 June 82 27 109
2023 May 90 48 138
2023 April 64 35 99
2023 March 51 24 75
2023 February 44 21 65
2023 January 41 23 64
2022 December 48 29 77
2022 November 48 46 94
2022 October 43 40 83
2022 September 56 23 79
2022 August 39 38 77
2022 July 24 48 72
2022 June 26 37 63
2022 May 31 40 71
2022 April 34 41 75
2022 March 45 46 91
2022 February 35 41 76
2022 January 45 33 78
2021 December 49 44 93
2021 November 44 27 71
2021 October 34 45 79
2021 September 23 33 56
2021 August 23 38 61
2021 July 34 23 57
2021 June 19 20 39
2021 May 42 27 69
2021 April 60 42 102
2021 March 52 31 83
2021 February 38 14 52
2021 January 27 19 46
2020 December 26 11 37
2020 November 26 13 39
2020 October 13 19 32
2020 September 22 11 33
2020 August 37 12 49
2020 July 25 11 36
2020 June 23 13 36
2020 May 30 19 49
2020 April 25 11 36
2020 March 33 17 50
2020 February 55 15 70
2020 January 71 16 87
2019 December 50 26 76
2019 November 28 14 42
2019 October 8 12 20
2019 September 14 17 31
2019 August 10 5 15
2019 July 15 18 33
2019 June 24 18 42
2019 May 11 16 27
2019 April 21 31 52
2019 March 31 18 49
2019 February 22 15 37
2019 January 25 27 52
2018 December 66 34 100
2018 November 140 34 174
2018 October 97 17 114
2018 September 78 20 98
2018 August 46 24 70
2018 July 55 14 69
2018 June 68 21 89
2018 May 53 14 67
2018 April 65 12 77
2018 March 63 10 73
2018 February 63 8 71
2018 January 50 7 57
2017 December 58 12 70
2017 November 33 15 48
2017 October 31 5 36
2017 September 43 16 59
2017 August 30 9 39
2017 July 37 15 52
2017 June 31 9 40
2017 May 31 11 42
2017 April 37 17 54
2017 March 26 30 56
2017 February 31 10 41
2017 January 22 10 32
2016 December 39 14 53
2016 November 58 10 68
2016 October 80 12 92
2016 September 89 3 92
2016 August 96 4 100
2016 July 140 10 150
2016 June 114 0 114
2016 May 114 0 114
2016 April 90 0 90
2016 March 61 0 61
2016 February 78 0 78
2016 January 100 0 100
2015 December 122 0 122
2015 November 88 0 88
2015 October 86 0 86
2015 September 46 0 46
2015 August 50 0 50
2015 July 66 0 66
2015 June 36 0 36
2015 May 42 0 42
2015 April 5 0 5
Show all

Follow this link to access the full text of the article

Idiomas
Nefrología (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?