was read the article
array:21 [ "pii" => "X2013251413002442" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Jun.11557" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:148-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5243 "formatos" => array:3 [ "EPUB" => 339 "HTML" => 4126 "PDF" => 778 ] ] "Traduccion" => array:1 [ "es" => array:17 [ "pii" => "X0211699513002445" "issn" => "02116995" "doi" => "10.3265/Nefrologia.pre2012.Jun.11557" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia. 2013;33:148-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 124888 "formatos" => array:3 [ "EPUB" => 418 "HTML" => 123066 "PDF" => 1404 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Reacción adversa por la administración intravenosa de hierro: ¿hipersensibilidad o efecto secundario?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "148" "paginaFinal" => "149" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Adverse reaction to intravenous iron: hypersensitivity or secondary side effect?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana E. Sirvent-Pedreño, Ricardo Enríquez-Ascarza, M. Dolores Redondo-Pachón, Isabel Millán-del Valle, César González-Martinez, Francisco Amorós-Amorós" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Ana E." "apellidos" => "Sirvent-Pedreño" ] 1 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Enríquez-Ascarza" ] 2 => array:2 [ "nombre" => "M. Dolores" "apellidos" => "Redondo-Pachón" ] 3 => array:2 [ "nombre" => "Isabel" "apellidos" => "Millán-del Valle" ] 4 => array:2 [ "nombre" => "César" "apellidos" => "González-Martinez" ] 5 => array:2 [ "nombre" => "Francisco" "apellidos" => "Amorós-Amorós" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X2013251413002442" "doi" => "10.3265/Nefrologia.pre2012.Jun.11557" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002442?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002445?idApp=UINPBA000064" "url" => "/02116995/0000003300000001/v0_201502091331/X0211699513002445/v0_201502091334/es/main.assets" ] ] "itemSiguiente" => array:17 [ "pii" => "X2013251413002434" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Sep.11626" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:149-50" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5945 "formatos" => array:3 [ "EPUB" => 344 "HTML" => 4847 "PDF" => 754 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Emphysematous cystitis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "149" "paginaFinal" => "150" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cistitis enfisematosa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "11626_16025_42305_en_f1_11626.jpg" "Alto" => 805 "Ancho" => 1373 "Tamanyo" => 114220 ] ] "descripcion" => array:1 [ "en" => "Emphysematous cystitis" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristina Vega-Cabrera, Olga Costero-Fernández, Begoña Rivas-Becerra, David Menéndez-González, Rafael Selgas-Gutiérrez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Cristina" "apellidos" => "Vega-Cabrera" ] 1 => array:2 [ "nombre" => "Olga" "apellidos" => "Costero-Fernández" ] 2 => array:2 [ "nombre" => "Begoña" "apellidos" => "Rivas-Becerra" ] 3 => array:2 [ "nombre" => "David" "apellidos" => "Menéndez-González" ] 4 => array:2 [ "nombre" => "Rafael" "apellidos" => "Selgas-Gutiérrez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "X0211699513002437" "doi" => "10.3265/Nefrologia.pre2012.Sep.11626" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002437?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002434?idApp=UINPBA000064" "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002434/v0_201502091556/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "X2013251413002450" "issn" => "20132514" "doi" => "10.3265/Nefrologia.pre2012.Aug.11661" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "documento" => "article" "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Nefrologia (English Version). 2013;33:147-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4211 "formatos" => array:3 [ "EPUB" => 327 "HTML" => 3213 "PDF" => 671 ] ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "A long-term follow-up of an Imerslund-Grasbeck syndrome patient with proteinuria" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "147" "paginaFinal" => "148" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Zafer Ercan, Mehmet E. Demir, Turgay Ulas, Muharrem Ingec, Mehmet Horoz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Zafer" "apellidos" => "Ercan" ] 1 => array:2 [ "nombre" => "Mehmet E." "apellidos" => "Demir" ] 2 => array:2 [ "nombre" => "Turgay" "apellidos" => "Ulas" ] 3 => array:2 [ "nombre" => "Muharrem" "apellidos" => "Ingec" ] 4 => array:2 [ "nombre" => "Mehmet" "apellidos" => "Horoz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "X0211699513002453" "doi" => "10.3265/Nefrologia.pre2012.Aug.11661" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699513002453?idApp=UINPBA000064" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002450?idApp=UINPBA000064" "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002450/v0_201502091556/en/main.assets" ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "Adverse reaction to intravenous iron: hypersensitivity or secondary side effect?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "148" "paginaFinal" => "149" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Ana E. Sirvent-Pedreño, Ricardo Enríquez-Ascarza, M. Dolores Redondo-Pachón, Isabel Millán-del Valle, César González-Martinez, Francisco Amorós-Amorós" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Ana E." "apellidos" => "Sirvent-Pedreño" "email" => array:1 [ 0 => "anaesipe@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Enríquez-Ascarza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "nombre" => "M. Dolores" "apellidos" => "Redondo-Pachón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "nombre" => "Isabel" "apellidos" => "Millán-del Valle" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "nombre" => "César" "apellidos" => "González-Martinez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "nombre" => "Francisco" "apellidos" => "Amorós-Amorós" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Nefrología, Hospital General Universitario de Elche, Elche, Alicante, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Reacción adversa por la administración intravenosa de hierro: ¿hipersensibilidad o efecto secundario?" ] ] "textoCompleto" => "<p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor:</span></p><p class="elsevierStylePara"> The replacement of iron is necessary in patients on haemodialysis due to the chronic blood loss that occurs when this technique is employed.<span class="elsevierStyleSup">1</span> The intravenous administration of iron is not, however, free from adverse effects. Amongst these, we distinguish certain predictable reactions (an undesired consequence of the pharmacological actions of iron, such as side effects) from unpredictable reactions (in subjects with sensitivity of the immune system or susceptible to reactions such as hypersensitive and anaphylactoid reactions).<span class="elsevierStyleSup">2</span> The latter are less common and more serious, and may require suspension of the drug. We describe the case of an adverse reaction to the intravenous administration of iron that manifested as a burning sensation of the tongue, an inadequately defined sensation of peribuccal hyperaesthesia and generalised pruritus.</p><p class="elsevierStylePara">The patient is a 42-year-old woman who began a haemodialysis programme by right jugular tunnelled catheter following bilateral nephrectomy due to hypernephroma. In the postoperative period, the patient required a transfusion of 2 units of packed red blood cells. Ten days later a test showed: haemoglobin: 9.6g/dl, haematocrit 28.4, mean corpuscular volume: 87.1fl; iron: 56µg/dl, ferritin 233ng/ml; transferrin saturation index: 18%; folic acid: 22ng/ml vitamin B<span class="elsevierStyleInf">12</span>: 921pg/ml; C-reactive protein: <5mg/l; Kt/V: 1.7. She was treated with omeprazole, vitamin B complex, folic acid and 30µg of darbepoetin weekly. 100mg of iron sucrose (Venofer<span class="elsevierStyleSup">®</span>) was administered intravenously an hour after haemodialysis. 15 minutes after starting infusion, the patient complained of generalised pruritus, a burning sensation of the tongue and peribuccal hyperaesthesia. Physical examination: blood pressure 100/60mmHg, heart and lung auscultation normal, no lesions of the skin. Iron administration was discontinued and the symptoms gradually disappeared. In the following attempt, the patient was premedicated with dexchlorpheniramine and paracetamol. The reaction was identical and also it occurred with ferric carboxymaltose (Ferinject<span class="elsevierStyleSup">®</span>). The Allergology Service was consulted: the patch test was negative for both iron preparations; the episode was compatible with the side effect. Clinical manifestations reappeared in a weaker form with the successive administrations of iron without major implications.</p><p class="elsevierStylePara">The rate of adverse effects associated with the administration of various preparations of intravenous iron (high and low molecular weight iron dextran, ferrous gluconate, iron sucrose) is approximately 38 per million.<span class="elsevierStyleSup">3</span> The pruritus associated with ferric carboxymaltose is described as isolated and infrequent (1/100-1000 of patients);<span class="elsevierStyleSup">4</span> it seems to be present upon the first administrations and subsequently dissapears.<span class="elsevierStyleSup">5</span> The symptoms described by the patient as a burning sensation of the tongue and peribuccal hyperaesthesia, although subject to subjective assessments, did not correspond to the neurological disorders commonly described as paraesthesia or taste disorders<span class="elsevierStyleSup">4</span>. The clinical profile that our patient presented seemed to signal an anaphylactoid reaction which was not confirmed. Generally speaking, reactions secondary to intravenous iron have been attributed to rapid infusion with an oversaturation of transferrin and the release of free iron, which is responsible for toxicity and vasomotor reactions.<span class="elsevierStyleSup">6</span> This limited the total dose of iron administered and the rate of infusion in older formulations. Although ferric carboxymaltose is in this sense better tolerated, there are few studies comparing it to the rest of the formulacions.<span class="elsevierStyleSup">7</span> Furthermore, the potential development of severe, even fatal adverse effects remains a source of concern. Many of these reactions have been associated with high molecular weight iron dextran preparations and seem to have an immunological base<span class="elsevierStyleSup">1,7</span>. However, controlled clinical trials for different intravenous iron preparations are limited by design to detect rare adverse effects as they are conducted in a small number of patients over short follow-up periods.<span class="elsevierStyleSup">1,2</span></p><p class="elsevierStylePara"><br></br> Given the manifestation of infrequent side effects, it is vitally important that the intensity and seriousness of the reaction be established since this may require the permanent suspension of the drug, with the resulting limitation of the therapeutic arsenal available.</p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">The authors declare that they have no conflicts of interest related to the contents of this article.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p>" "pdfFichero" => "P1-E547-S3873-A11557-EN.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/20132514/0000003300000001/v0_201502091555/X2013251413002442/v0_201502091556/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003300000001/v0_201502091555/X2013251413002442/v0_201502091556/en/P1-E547-S3873-A11557-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251413002442?idApp=UINPBA000064" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 23 | 7 | 30 |
2024 October | 147 | 26 | 173 |
2024 September | 123 | 32 | 155 |
2024 August | 119 | 53 | 172 |
2024 July | 140 | 30 | 170 |
2024 June | 157 | 40 | 197 |
2024 May | 164 | 48 | 212 |
2024 April | 154 | 33 | 187 |
2024 March | 151 | 31 | 182 |
2024 February | 99 | 30 | 129 |
2024 January | 103 | 24 | 127 |
2023 December | 117 | 23 | 140 |
2023 November | 133 | 40 | 173 |
2023 October | 121 | 27 | 148 |
2023 September | 151 | 33 | 184 |
2023 August | 135 | 20 | 155 |
2023 July | 167 | 37 | 204 |
2023 June | 117 | 36 | 153 |
2023 May | 155 | 62 | 217 |
2023 April | 77 | 26 | 103 |
2023 March | 91 | 27 | 118 |
2023 February | 90 | 19 | 109 |
2023 January | 96 | 25 | 121 |
2022 December | 84 | 30 | 114 |
2022 November | 69 | 43 | 112 |
2022 October | 70 | 53 | 123 |
2022 September | 56 | 34 | 90 |
2022 August | 76 | 51 | 127 |
2022 July | 64 | 45 | 109 |
2022 June | 68 | 41 | 109 |
2022 May | 76 | 49 | 125 |
2022 April | 92 | 48 | 140 |
2022 March | 77 | 50 | 127 |
2022 February | 80 | 50 | 130 |
2022 January | 51 | 36 | 87 |
2021 December | 53 | 38 | 91 |
2021 November | 58 | 35 | 93 |
2021 October | 53 | 49 | 102 |
2021 September | 53 | 49 | 102 |
2021 August | 58 | 35 | 93 |
2021 July | 43 | 30 | 73 |
2021 June | 44 | 31 | 75 |
2021 May | 52 | 28 | 80 |
2021 April | 97 | 33 | 130 |
2021 March | 90 | 39 | 129 |
2021 February | 83 | 37 | 120 |
2021 January | 44 | 29 | 73 |
2020 December | 75 | 17 | 92 |
2020 November | 66 | 28 | 94 |
2020 October | 44 | 30 | 74 |
2020 September | 53 | 13 | 66 |
2020 August | 65 | 17 | 82 |
2020 July | 51 | 16 | 67 |
2020 June | 46 | 23 | 69 |
2020 May | 62 | 19 | 81 |
2020 April | 59 | 17 | 76 |
2020 March | 59 | 21 | 80 |
2020 February | 63 | 23 | 86 |
2020 January | 70 | 17 | 87 |
2019 December | 87 | 34 | 121 |
2019 November | 60 | 18 | 78 |
2019 October | 57 | 15 | 72 |
2019 September | 60 | 17 | 77 |
2019 August | 59 | 8 | 67 |
2019 July | 59 | 25 | 84 |
2019 June | 60 | 19 | 79 |
2019 May | 50 | 22 | 72 |
2019 April | 63 | 49 | 112 |
2019 March | 48 | 22 | 70 |
2019 February | 32 | 22 | 54 |
2019 January | 27 | 24 | 51 |
2018 December | 67 | 38 | 105 |
2018 November | 121 | 32 | 153 |
2018 October | 106 | 24 | 130 |
2018 September | 70 | 24 | 94 |
2018 August | 70 | 27 | 97 |
2018 July | 62 | 16 | 78 |
2018 June | 57 | 17 | 74 |
2018 May | 70 | 17 | 87 |
2018 April | 63 | 14 | 77 |
2018 March | 63 | 12 | 75 |
2018 February | 63 | 13 | 76 |
2018 January | 51 | 10 | 61 |
2017 December | 55 | 9 | 64 |
2017 November | 46 | 12 | 58 |
2017 October | 36 | 14 | 50 |
2017 September | 42 | 9 | 51 |
2017 August | 34 | 12 | 46 |
2017 July | 37 | 19 | 56 |
2017 June | 40 | 6 | 46 |
2017 May | 42 | 14 | 56 |
2017 April | 30 | 15 | 45 |
2017 March | 41 | 25 | 66 |
2017 February | 28 | 12 | 40 |
2017 January | 21 | 19 | 40 |
2016 December | 46 | 6 | 52 |
2016 November | 54 | 14 | 68 |
2016 October | 82 | 10 | 92 |
2016 September | 116 | 4 | 120 |
2016 August | 157 | 9 | 166 |
2016 July | 193 | 16 | 209 |
2016 June | 110 | 0 | 110 |
2016 May | 156 | 0 | 156 |
2016 April | 120 | 0 | 120 |
2016 March | 79 | 0 | 79 |
2016 February | 124 | 0 | 124 |
2016 January | 115 | 0 | 115 |
2015 December | 115 | 0 | 115 |
2015 November | 110 | 0 | 110 |
2015 October | 118 | 0 | 118 |
2015 September | 74 | 0 | 74 |
2015 August | 81 | 0 | 81 |
2015 July | 80 | 0 | 80 |
2015 June | 48 | 0 | 48 |
2015 May | 58 | 0 | 58 |
2015 April | 7 | 0 | 7 |