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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor</span>&#58;<span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">Autoimmune pancreatitis &#40;AIP&#41; is a form of chronic pancreatitis caused by an autoimmune inflammatory process with lymphocyte infiltration and fibrosis that lead to organ dysfunction&#44;1 related to high levels of IgG4 and anti-carbonic anhydrase II antibodies&#46;2&#44;3 This disease frequently produces extra-pancreatic manifestations as well&#44; such as sclerosing cholangitis and tubulointerstitial nephritis&#46;4</p><p class="elsevierStylePara">Sclerosing cholangitis associated with AIP produces imaging test results and a clinical presentation similar to that of primary sclerosing cholangitis &#40;PSC&#41;&#44; but has a dramatic response to steroid treatment&#46;5</p><p class="elsevierStylePara">Here&#44; we describe the case of a patient with repeated episodes of pancreatitis and cholangitis who was managed as a case of PSC with no response&#44; and who developed tubulointerstitial nephritis with renal biopsy findings suggestive of an autoimmune process&#44; with resolution of gastrointestinal and renal manifestations through the administration of steroids&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Our patient was a 37-year old male who sought treatment in March 2006 for jaundice&#44; fever&#44; and abdominal pain&#59; we first suspected an episode of cholangitis&#44; but an endoscopic retrograde cholangiopancreatography and p-ANCA tests due to suspected PSC were negative&#44; leading to the suspicion of microlithiasis&#46;</p><p class="elsevierStylePara">In May of 2006&#44; we performed an endoscopic sphincterotomy&#46; Eight days later&#44; the patient showed another episode of cholangitis&#46; We considered the possibility of acalculous gallbladder disease as the cause for the recurring cholangitis&#59; a cholecystokinin scintigraphy was compatible with this diagnosis&#44; and we performed a laparoscopic cholecystectomy&#44; but 15 days later the patient returned with yet another episode of cholangitis&#46;</p><p class="elsevierStylePara">We returned to the suspected diagnosis of PSC&#44; and performed a liver biopsy that revealed acute cholangitis with minimal foci of fibrosis&#46; In early 2007&#44; we administered a magnetic resonance cholangiography that revealed constrictions that were compatible with the diagnosis of PSC&#44; with no possibility of performing a surgical intervention&#46;</p><p class="elsevierStylePara">We managed the patient as a case of PSC&#44; administering ursodeoxycholic acid and low doses of antibiotics &#40;ciprofloxacin&#41;&#44; and yet the patient continued to suffer repeated episodes of cholangitis&#46;</p><p class="elsevierStylePara">In October 2007&#44; the patient sought treatment for fever and abdominal pain&#59; we started treatment with ciprofloxacin and requested an abdominal contrast tomography based on the patient&#8217;s creatinine value of 8&#46;7mg&#47;dl&#46; In May 2007&#44; the patient&#8217;s creatinine value was 1&#46;2mg&#47;dl&#46;</p><p class="elsevierStylePara">The patient was evaluated in nephrology&#44; and the only finding was paleness&#46;</p><p class="elsevierStylePara">Laboratory analyses revealed creatinine&#58; 7&#46;6mg&#47;dl&#44; blood urea nitrogen &#40;BUN&#41;&#58; 46&#44; normal sodium and potassium levels&#44; pH&#58; 7&#46;32&#44; bicarbonate&#58; 16&#44; Hb&#58; 9&#46;7g&#47;dl&#44; urinalysis with glycosuria &#40;50mg&#47;dl&#41; and no hyperglycaemia&#46;</p><p class="elsevierStylePara">A renal ultrasound revealed normally sized kidneys with increased bilateral echogenicity&#46;</p><p class="elsevierStylePara">The patient was diagnosed with acute renal failure secondary to tubulointerstitial nephritis due to the consumption of quinolones&#46;</p><p class="elsevierStylePara">After antibiotic treatment was removed and the patient was hydrated on the following day&#44; creatinine decreased to 5&#46;5mg&#47;dl and BUN to 36mg&#47;dl&#46; Serum complement was normal&#44; anti-nuclear antibodies &#40;ANA&#41; and serological tests for syphilis &#40;VDRL&#41; and human immunodeficiency virus &#40;HIB&#41; were negative&#59; 24-hour proteinuria was 580mg&#46; The patient was discharged with a creatinine value of 2&#46;2mg&#47;dl&#46;</p><p class="elsevierStylePara">Twenty days later&#44; the patient returned again for treatment for fever&#44; diarrhoea&#44; and oedema&#46; Upon hospitalisation the patient had a creatinine value of 15mg&#47;dl&#44; potassium at 5&#46;8mEq&#47;l&#44; and urine cytochemistry revealed leukocyturia&#44; proteinuria &#40;25mg&#47;dl&#41;&#44; glycosuria &#40;50mg&#47;dl&#41;&#44; and haematuria &#40;erythrocytes&#58; 6 per field&#41;&#46; A physical examination revealed no pathological findings&#46; We considered this to be an exacerbation of the previous case of renal failure&#59; due to the suspicion of tubulointerstitial nephritis&#44; we started treatment with prednisone and took a renal biopsy&#46;</p><p class="elsevierStylePara">The renal biopsy revealed&#58; acute tubulointerstitial nephritis&#59; immunofluorescence revealed&#58; IgG &#43;&#43; &#40;interstitial&#41;&#44; IgA and IgM &#43;&#43;&#43; &#40;interstitial&#41;&#44; k and lambda chains&#58; absent&#44; C3&#58; &#43;&#43;&#43; peripheral&#44; M and Bowman&#8217;s capsule&#44; and absence of C1q&#46; We interpreted these findings as histological changes corresponding to acute tubulointerstitial nephritis due to hypersensitivity to medications as opposed to autoimmune&#46;</p><p class="elsevierStylePara">We continued to treat the patient with steroids&#44; and upon discharge&#44; creatinine was at 3&#46;6mg&#47;dl&#46;</p><p class="elsevierStylePara">Since starting the patient on steroids&#44; no further episodes of cholangitis or pancreatitis were produced&#44; which led to the diagnosis of AIP with sclerosing cholangitis and tubulointerstitial nephritis as extra-pancreatic complications&#46;</p><p class="elsevierStylePara">We did not measure IgG4 levels&#44; since the patient had already received steroid treatment&#46;</p><p class="elsevierStylePara">The first outpatient follow-up consultation revealed creatinine at 1&#46;6mg&#47;dl&#46; The steroid treatment was progressively decreased&#44; and the patient is currently on a regimen of 5mg prednisone every other day indefinitely&#46; Follow-up measurements of creatinine revealed values ranging from 1&#46;4mg&#47;dl-1&#46;7mg&#47;dl&#46;</p><p class="elsevierStylePara">The last follow-up session in December 2010 showed the patient&#8217;s creatinine value to be 1&#46;43mg&#47;dl&#44; and no new episodes of cholangitis or pancreatitis have occurred&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">In 1961&#44; Starles made the first description of chronic pancreatitis with autoimmune manifestations&#59; later&#44; in 1995&#44; this form of pancreatitis was labelled by Yoshida as &#8220;autoimmune pancreatitits&#8221;&#46;6</p><p class="elsevierStylePara">Although the number of reports of this disease has recently increased&#44; and some studies report a prevalence of 5&#37; among patients with chronic pancreatitis&#44; the true incidence of AIP remains unknown&#46;7</p><p class="elsevierStylePara">AIP is frequently associated with rheumatoid arthritis&#44; Sj&#246;gren&#8217;s syndrome&#44; and inflammatory bowel disease&#59; it is also common to encounter hypergammaglobulinaemia and elevated IgG4 levels&#44; anti-carbonic anhydrase II&#44; and lactoferrin auto-antibodies&#44; which suggests an autoimmune disease&#44; although its pathogenesis is still unkown&#46;1-3</p><p class="elsevierStylePara">The extra-pancreatic autoimmune manifestations of AIP include sclerosing sialadenitis&#44; retroperitoneal fibrosis&#44; interstitial pneumonitis&#44; sclerosing cholangitis&#44; and tubulointerstitial nephritis&#46;4&#44;8</p><p class="elsevierStylePara">As regards sclerosing cholangitis associated with this type of pancreatitis&#44; diagnosis is hindered by the fact that this condition shares many imaging test&#44; cholangiography&#44; and clinical findings with PSC&#59; several authors have reported that the appearance of this disease in patients older than 60 years of age&#44; with elevated levels of IgG4&#44; and a dramatic response to steroid treatment all favour the diagnosis of AIP-associated sclerosing cholangitis as opposed to PSC&#46;5</p><p class="elsevierStylePara">Various diagnostic criteria have been suggested for AIP&#59; these include the revised Japan criteria&#44; which place special emphasis on imaging test findings&#44; the Mayo Clinic criteria &#40;HISORT&#41;&#44; which involve the use of histological&#44; imaging test&#44; and serology findings&#44; as well as the manifestations in other organs and response to steroids&#44; and the Italian criteria&#44; which give greater importance to histological findings&#59; however&#44; no unified international consensus exists regarding which diagnostic criteria to use&#46;9</p><p class="elsevierStylePara">As yet&#44; few cases of tubulointerstitial nephritis have been reported in association with AIP&#59; generally&#44; these are observed in male patients older than 50 years of age&#44; with mononuclear cell infiltrates that are positive for IgG4 in the renal interstitium&#44; and with clinical and serological &#40;decreased IgG4 levels&#41; evidence of response to steroid treatment&#46;8&#44;10</p><p class="elsevierStylePara">Despite the lack of information regarding IgG4 levels in our patient&#44; there were elements to suggest sclerosing cholangitis and tubulointerstitial nephritis associated with AIP&#58; frequent episodes of cholangitis with magnetic resonance cholangiography findings that initially produced the suspicion of PSC&#44; but the patient showed little response to normal treatment and had no auto-antibodies &#40;p-ANCA&#44; ANA&#41;&#44; which are present in 85&#37; of all patients with this pathology&#59; this was supported by the repeated episodes of pancreatitis with evidence of diffuse growth of the pancreas&#44; and resolution of symptoms through treatment with steroids&#46;</p><p class="elsevierStylePara">The renal biopsy findings&#44; 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                  "referenciaCompleta" => "Ohara H, Nakazawa T, Ando T, Joh T. Systemic extrapancreatic lesions associated with autoimmune pancreatitis. J Gastroenterol 2007;42 Suppl 18:15-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17520218" target="_blank">[Pubmed]</a>"
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                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
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                    0 => null
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                  "contribucion" => array:1 [
                    0 => null
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Tubulointerstitial nephritis and sclerosing cholangitis associated with autoimmune pancreatitis
Nefritis tubulointersticial y colangitis esclerosante asociadas a pancreatitis autoinmune
Arbey Aristizabal-Alzatea, Carolina Muñoz-Grajalesa, Catalina Ocampo-Kohna, John F. Nieto-Ríosa, Gustavo A. Zuluaga-Valenciaa
a Sección de Nefrología, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia,
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor</span>&#58;<span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara">Autoimmune pancreatitis &#40;AIP&#41; is a form of chronic pancreatitis caused by an autoimmune inflammatory process with lymphocyte infiltration and fibrosis that lead to organ dysfunction&#44;1 related to high levels of IgG4 and anti-carbonic anhydrase II antibodies&#46;2&#44;3 This disease frequently produces extra-pancreatic manifestations as well&#44; such as sclerosing cholangitis and tubulointerstitial nephritis&#46;4</p><p class="elsevierStylePara">Sclerosing cholangitis associated with AIP produces imaging test results and a clinical presentation similar to that of primary sclerosing cholangitis &#40;PSC&#41;&#44; but has a dramatic response to steroid treatment&#46;5</p><p class="elsevierStylePara">Here&#44; we describe the case of a patient with repeated episodes of pancreatitis and cholangitis who was managed as a case of PSC with no response&#44; and who developed tubulointerstitial nephritis with renal biopsy findings suggestive of an autoimmune process&#44; with resolution of gastrointestinal and renal manifestations through the administration of steroids&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">CASE REPORT</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">Our patient was a 37-year old male who sought treatment in March 2006 for jaundice&#44; fever&#44; and abdominal pain&#59; we first suspected an episode of cholangitis&#44; but an endoscopic retrograde cholangiopancreatography and p-ANCA tests due to suspected PSC were negative&#44; leading to the suspicion of microlithiasis&#46;</p><p class="elsevierStylePara">In May of 2006&#44; we performed an endoscopic sphincterotomy&#46; Eight days later&#44; the patient showed another episode of cholangitis&#46; We considered the possibility of acalculous gallbladder disease as the cause for the recurring cholangitis&#59; a cholecystokinin scintigraphy was compatible with this diagnosis&#44; and we performed a laparoscopic cholecystectomy&#44; but 15 days later the patient returned with yet another episode of cholangitis&#46;</p><p class="elsevierStylePara">We returned to the suspected diagnosis of PSC&#44; and performed a liver biopsy that revealed acute cholangitis with minimal foci of fibrosis&#46; In early 2007&#44; we administered a magnetic resonance cholangiography that revealed constrictions that were compatible with the diagnosis of PSC&#44; with no possibility of performing a surgical intervention&#46;</p><p class="elsevierStylePara">We managed the patient as a case of PSC&#44; administering ursodeoxycholic acid and low doses of antibiotics &#40;ciprofloxacin&#41;&#44; and yet the patient continued to suffer repeated episodes of cholangitis&#46;</p><p class="elsevierStylePara">In October 2007&#44; the patient sought treatment for fever and abdominal pain&#59; we started treatment with ciprofloxacin and requested an abdominal contrast tomography based on the patient&#8217;s creatinine value of 8&#46;7mg&#47;dl&#46; In May 2007&#44; the patient&#8217;s creatinine value was 1&#46;2mg&#47;dl&#46;</p><p class="elsevierStylePara">The patient was evaluated in nephrology&#44; and the only finding was paleness&#46;</p><p class="elsevierStylePara">Laboratory analyses revealed creatinine&#58; 7&#46;6mg&#47;dl&#44; blood urea nitrogen &#40;BUN&#41;&#58; 46&#44; normal sodium and potassium levels&#44; pH&#58; 7&#46;32&#44; bicarbonate&#58; 16&#44; Hb&#58; 9&#46;7g&#47;dl&#44; urinalysis with glycosuria &#40;50mg&#47;dl&#41; and no hyperglycaemia&#46;</p><p class="elsevierStylePara">A renal ultrasound revealed normally sized kidneys with increased bilateral echogenicity&#46;</p><p class="elsevierStylePara">The patient was diagnosed with acute renal failure secondary to tubulointerstitial nephritis due to the consumption of quinolones&#46;</p><p class="elsevierStylePara">After antibiotic treatment was removed and the patient was hydrated on the following day&#44; creatinine decreased to 5&#46;5mg&#47;dl and BUN to 36mg&#47;dl&#46; Serum complement was normal&#44; anti-nuclear antibodies &#40;ANA&#41; and serological tests for syphilis &#40;VDRL&#41; and human immunodeficiency virus &#40;HIB&#41; were negative&#59; 24-hour proteinuria was 580mg&#46; The patient was discharged with a creatinine value of 2&#46;2mg&#47;dl&#46;</p><p class="elsevierStylePara">Twenty days later&#44; the patient returned again for treatment for fever&#44; diarrhoea&#44; and oedema&#46; Upon hospitalisation the patient had a creatinine value of 15mg&#47;dl&#44; potassium at 5&#46;8mEq&#47;l&#44; and urine cytochemistry revealed leukocyturia&#44; proteinuria &#40;25mg&#47;dl&#41;&#44; glycosuria &#40;50mg&#47;dl&#41;&#44; and haematuria &#40;erythrocytes&#58; 6 per field&#41;&#46; A physical examination revealed no pathological findings&#46; We considered this to be an exacerbation of the previous case of renal failure&#59; due to the suspicion of tubulointerstitial nephritis&#44; we started treatment with prednisone and took a renal biopsy&#46;</p><p class="elsevierStylePara">The renal biopsy revealed&#58; acute tubulointerstitial nephritis&#59; immunofluorescence revealed&#58; IgG &#43;&#43; &#40;interstitial&#41;&#44; IgA and IgM &#43;&#43;&#43; &#40;interstitial&#41;&#44; k and lambda chains&#58; absent&#44; C3&#58; &#43;&#43;&#43; peripheral&#44; M and Bowman&#8217;s capsule&#44; and absence of C1q&#46; We interpreted these findings as histological changes corresponding to acute tubulointerstitial nephritis due to hypersensitivity to medications as opposed to autoimmune&#46;</p><p class="elsevierStylePara">We continued to treat the patient with steroids&#44; and upon discharge&#44; creatinine was at 3&#46;6mg&#47;dl&#46;</p><p class="elsevierStylePara">Since starting the patient on steroids&#44; no further episodes of cholangitis or pancreatitis were produced&#44; which led to the diagnosis of AIP with sclerosing cholangitis and tubulointerstitial nephritis as extra-pancreatic complications&#46;</p><p class="elsevierStylePara">We did not measure IgG4 levels&#44; since the patient had already received steroid treatment&#46;</p><p class="elsevierStylePara">The first outpatient follow-up consultation revealed creatinine at 1&#46;6mg&#47;dl&#46; The steroid treatment was progressively decreased&#44; and the patient is currently on a regimen of 5mg prednisone every other day indefinitely&#46; Follow-up measurements of creatinine revealed values ranging from 1&#46;4mg&#47;dl-1&#46;7mg&#47;dl&#46;</p><p class="elsevierStylePara">The last follow-up session in December 2010 showed the patient&#8217;s creatinine value to be 1&#46;43mg&#47;dl&#44; and no new episodes of cholangitis or pancreatitis have occurred&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">DISCUSSION</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">In 1961&#44; Starles made the first description of chronic pancreatitis with autoimmune manifestations&#59; later&#44; in 1995&#44; this form of pancreatitis was labelled by Yoshida as &#8220;autoimmune pancreatitits&#8221;&#46;6</p><p class="elsevierStylePara">Although the number of reports of this disease has recently increased&#44; and some studies report a prevalence of 5&#37; among patients with chronic pancreatitis&#44; the true incidence of AIP remains unknown&#46;7</p><p class="elsevierStylePara">AIP is frequently associated with rheumatoid arthritis&#44; Sj&#246;gren&#8217;s syndrome&#44; and inflammatory bowel disease&#59; it is also common to encounter hypergammaglobulinaemia and elevated IgG4 levels&#44; anti-carbonic anhydrase II&#44; and lactoferrin auto-antibodies&#44; which suggests an autoimmune disease&#44; although its pathogenesis is still unkown&#46;1-3</p><p class="elsevierStylePara">The extra-pancreatic autoimmune manifestations of AIP include sclerosing sialadenitis&#44; retroperitoneal fibrosis&#44; interstitial pneumonitis&#44; sclerosing cholangitis&#44; and tubulointerstitial nephritis&#46;4&#44;8</p><p class="elsevierStylePara">As regards sclerosing cholangitis associated with this type of pancreatitis&#44; diagnosis is hindered by the fact that this condition shares many imaging test&#44; cholangiography&#44; and clinical findings with PSC&#59; several authors have reported that the appearance of this disease in patients older than 60 years of age&#44; with elevated levels of IgG4&#44; and a dramatic response to steroid treatment all favour the diagnosis of AIP-associated sclerosing cholangitis as opposed to PSC&#46;5</p><p class="elsevierStylePara">Various diagnostic criteria have been suggested for AIP&#59; these include the revised Japan criteria&#44; which place special emphasis on imaging test findings&#44; the Mayo Clinic criteria &#40;HISORT&#41;&#44; which involve the use of histological&#44; imaging test&#44; and serology findings&#44; as well as the manifestations in other organs and response to steroids&#44; and the Italian criteria&#44; which give greater importance to histological findings&#59; however&#44; no unified international consensus exists regarding which diagnostic criteria to use&#46;9</p><p class="elsevierStylePara">As yet&#44; few cases of tubulointerstitial nephritis have been reported in association with AIP&#59; generally&#44; these are observed in male patients older than 50 years of age&#44; with mononuclear cell infiltrates that are positive for IgG4 in the renal interstitium&#44; and with clinical and serological &#40;decreased IgG4 levels&#41; evidence of response to steroid treatment&#46;8&#44;10</p><p class="elsevierStylePara">Despite the lack of information regarding IgG4 levels in our patient&#44; there were elements to suggest sclerosing cholangitis and tubulointerstitial nephritis associated with AIP&#58; frequent episodes of cholangitis with magnetic resonance cholangiography findings that initially produced the suspicion of PSC&#44; but the patient showed little response to normal treatment and had no auto-antibodies &#40;p-ANCA&#44; ANA&#41;&#44; which are present in 85&#37; of all patients with this pathology&#59; this was supported by the repeated episodes of pancreatitis with evidence of diffuse growth of the pancreas&#44; and resolution of symptoms through treatment with steroids&#46;</p><p class="elsevierStylePara">The renal biopsy findings&#44; specifically those from immunofluorescence testing&#44; favoured the diagnosis of an autoimmune mechanism responsible for producing the tubulointerstitial nephritis observed in this patient&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">&#160;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors state that they have no potential conflicts of interest related to the content of this article&#46;</p><p class="elsevierStylePara">&#160;</p>"
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                  "referenciaCompleta" => "Finkelberg DL, Sahani D, Deshpande V, Brugge WR. Current concepts Autoimmune pancreatitis. N Engl J Med 2006;355:2670-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17182992" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Okazaki K, Uchida K, Ohana M,\u{A0}Nakase H, Uose S, Inai M,\u{A0}et al. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2- type cellular immune response. Gastroenterology 2000;118:573-81. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10702209" target="_blank">[Pubmed]</a>"
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                  "referenciaCompleta" => "Aparisi L, Farre A, Gomez-Cambronero L, Martinez J, De Las Heras G, Corts J, et al. Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis. Gut 2005;54:703-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15831920" target="_blank">[Pubmed]</a>"
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                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Ohara H, Nakazawa T, Ando T, Joh T. Systemic extrapancreatic lesions associated with autoimmune pancreatitis. J Gastroenterol 2007;42 Suppl 18:15-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17520218" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
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                  "referenciaCompleta" => "5.\u{A0}Nishino T,\u{A0}Oyama H,\u{A0}Hashimoto E,\u{A0}Toki F,\u{A0}Oi I,\u{A0}Kobayashi M,\u{A0}et al. Clinicopathological differentiation between sclerosing cholangitis with autoimmune pancreatitis and primary sclerosing cholangitis. J Gastroenterol 2007;42:550-9. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17653651" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
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                0 => array:3 [
                  "referenciaCompleta" => "Song Y, Liu QD, Zhou NX, Zhang WZ, Wang DJ. Diagnosis and management of autoimmune pancreatitis: Experience from China. World J Gastroenterol 2008;14(4):601-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18203294" target="_blank">[Pubmed]</a>"
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                0 => array:3 [
                  "referenciaCompleta" => "Lin LF, Huang PT, Ho KS, Tung JN. Autoimmune Chronic Pancreatitis. J Chin Med Assoc 2008;71(1):14-22."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                  "referenciaCompleta" => "8.\u{A0}Uchiyama-Tanaka Y,\u{A0}Mori Y,\u{A0}Kimura T,\u{A0}Sonomura K, et al. Acute Tubulointerstitial Nephritis Associated With Autoimmune-Related Pancreatitis. Am J Kidney Dis 2004;43(3):18-25."
                  "contribucion" => array:1 [
                    0 => null
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                  "host" => array:1 [
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              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Nishimori I,\u{A0}Onishi S,\u{A0}Otsuki M. Review of diagnostic criteria for autoimmune pancreatitis; for establishment of international criteria. Clin J Gastroenterol 2008;1:7-17."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
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                0 => array:3 [
                  "referenciaCompleta" => "Yoneda K, Murata K, Katayama K, Ishikawa E, Fuke H, Yamamoto N, et al. Tubulointerstitial nephritis associated with IgG4-related autoimmune disease. Am J Kidney Dis 2007;50(3):455-62. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17720525" target="_blank">[Pubmed]</a>"
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                    0 => null
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