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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#58;</span></p><p class="elsevierStylePara">Rhabdomyolysis &#40;RD&#41; is the process of cellular necrosis in striated muscle&#44; with the release of intracellular components into the blood stream&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Acute renal failure &#40;ARF&#41; appears in 15&#37;-50&#37; of cases of RD&#44; and can be associated with altered calcium metabolism with a biphasic pattern&#46; In the initial oliguric phase&#44; 60&#37; of patients with RD can develop hypocalcaemia&#46;<span class="elsevierStyleSup">2</span> In the recovery phase of ARF&#44; 20&#37;-30&#37; can develop hypercalcaemia&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The cases described in the literature of RD with hypercalcaemia equal to or greater than 15mg&#47;dl correspond to patients that initially suffered severe hypocalcaemia&#46;<span class="elsevierStyleSup">3-7</span></p><p class="elsevierStylePara">Here we present the case of RD secondary to intense exercise during grape harvest and associated with ARF&#44; in which&#44; following a mild initial bout of hypocalcaemia&#44; the patient developed severe hypercalcaemia at 15&#46;4mg&#47;dl&#46;</p><p class="elsevierStylePara">Our patient was a 21-year-old male with no relevant medical background&#46; Fifteen days prior to hospitalisation&#44; the patient started to suffer general malaise&#44; muscle pain&#44; vomiting&#44; swelling of the legs&#44; and dark urine followed by oligoanuria&#44; following intense exercise during grape harvest&#46; The patient&#8217;s primary physician started treatment with prokinetics&#44; muscle relaxants&#44; and antibiotics &#40;norfloxacin&#41;&#44; with no improvement&#46; A physical examination revealed skin and mucosae dehydration and bradypsychia&#46; The patient&#8217;s blood pressure was 150&#47;60mm Hg&#44; with a soft abdomen that produced slight pain upon deep palpation&#46; The muscles in the limbs were hardened&#44; and all other results were normal&#46;</p><p class="elsevierStylePara">A laboratory analysis revealed&#58; creatinine&#58; 16&#46;2mg&#47;dl&#59; urea&#58; 411mg&#47;dl&#59; maximum creatinine phosphokinase &#40;CPK&#41;&#58; 1000U&#47;l&#59; total protein&#58; 6&#46;3g&#47;dl&#59; albumin&#58; 3&#46;9g&#47;dl&#59; Na&#58; 134mEq&#47;l&#59; K&#58; 4mEq&#47;l&#59; Ca&#58; 7&#46;9mg&#47;dl&#59; P&#58; 9&#46;3mg&#47;dl&#46; A urine analysis revealed red blood cells &#43;&#43;&#43; and urinary sediment&#58; 7-8 red blood cells&#47;field &#40;Figure&#41;&#46; Viral serology &#40;for hepatitis B and C and human immunodeficiency virus&#41; was negative&#46; Chest x-ray and abdominal ultrasound results were normal&#46;</p><p class="elsevierStylePara">Given the patient&#8217;s severe state of nitrogen retention and symptoms indicative of uremic encephalopathy&#44; we administered two sessions of haemodialysis&#44; intense hydration therapy&#44; and urine alkalinisation&#46; This produced improvements in the clinical symptoms and laboratory results&#46; Despite this improvement&#44; the patient continued to suffer vomiting on the seventh day of treatment&#59; we performed more tests&#44; observing hypercalcaemia at 15&#46;4mg&#47;dl&#46; We administered intense hydration therapy&#44; diuretic treatment&#44; calcitonin&#44; and bisphosphonates&#46; Parathyroid hormone &#40;PTH&#41; levels were 7&#46;97pg&#47;ml&#44; and 25-dihydroxyvitamin D was at 22nmol&#47;l&#46; Upon discharge&#44; the patient&#8217;s creatinine level was 1&#46;8mg&#47;dl&#44; CPK was normal&#44; and serum Ca was at 8&#46;5mg&#47;dl&#46; In later follow-up sessions&#44; creatinine was at 0&#46;8mg&#47;dl and Ca and CPK values were with normal ranges &#40;Figure&#41;&#46;</p><p class="elsevierStylePara">Reviewing the medical literature&#44; we can observe more than 60 cases published since 1970 of hypercalcaemia associated with RD&#46;<span class="elsevierStyleSup">3-9</span> We can also note that the majority of cases described of hypercalcaemia &#62;15mg&#47;dl&#44; such as in our case&#44; initially present severe hypocalcaemia&#46;<span class="elsevierStyleSup">3-7</span> Our patient had mild hypocalcaemia at 7&#46;9mg&#47;dl during the oligoanuric phase&#44; and later developed hypercalcaemia at 15&#46;4mg&#47;dl&#46; In a similar manner&#44; Grobety et al&#46; described two cases of patients with mild hypocalcaemia during initial phases of RD&#44; at 7&#46;4mg&#47;dl and 7&#46;6mg&#47;dl&#44; who later developed severe hypercalcaemia at 15&#46;6mg&#47;dl and 15mg&#47;dl&#44; respectively&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">Hypocalcaemia in RD tends to appear in the oliguric phase of ARF&#44; is normally temporary&#44; and can occasionally be severe and symptomatic&#46; Treatment with calcium salts and&#47;or vitamin D derivatives should be avoided&#44; since this could aggravate the state of hypercalcaemia produced in the recovery phase of RD&#46;<span class="elsevierStyleSup">9</span> Our patient did not require treatment&#44; since the hypocalcaemia was mild and asymptomatic&#46;</p><p class="elsevierStylePara">Hypercalcaemia in RD tends to occur in the phase of recovery of diuresis in the associated ARF&#59; this is primarily due to the release of calcium deposited in the muscles into the bloodstream&#44; along with mild hyperparathyroidism caused by renal failure&#46;<span class="elsevierStyleSup">4&#44;9</span> The majority of cases of hypercalcaemia are self-limiting&#44; and may only need observation and adequate hydration&#46;<span class="elsevierStyleSup">2</span> However&#44; certain patients require treatment with bisphosphonates&#44; calcitonin&#44; and loop diuretics&#44;<span class="elsevierStyleSup">2 </span>as in our case&#46;</p><p class="elsevierStylePara">Our patient did not require sequential PTH measurements during hospitalisation&#44; but during the phase of recovery from diuresis&#44; he did develop severe hypercalcaemia with suppressed PTH&#44; as in the majority of described cases&#46; However&#44; calcitriol levels were normal&#44; in contrast with the low levels described by other authors&#46;<span class="elsevierStyleSup">3&#44;4</span></p><p class="elsevierStylePara">To conclude&#44; the majority of cases of ARF associated with RD and severe hypercalcaemia initially present the form of severe hypocalcaemia&#44; and occasionally mild hypocalcaemia&#46; We described a case of severe hypercalcaemia in a patient with an initial mild decrease in calcium levels&#46; This suggests that severe hypercalcaemia following mild hypocalcaemia might be the result of approaching the case of RD when it was already substantially progressed&#44; or due to outside factors&#46; Our case may have been one of late RD&#44; although we cannot confirm this&#44; since we do not have laboratory analyses from before the patient was hospitalised&#46; However&#44; when presented with a patient with ARF and RD&#44; we must monitor calcium kinetics alterations&#44; even when serum calcium levels in the initial phase are normal or only slightly low&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11577&#95;16025&#95;35738&#95;en&#95;f111577&#46;jpg" class="elsevierStyleCrossRefs"><img src="11577_16025_35738_en_f111577.jpg" alt="Evolution of calcium&#44; 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Massive hypercalcaemia in rhabdomyolysis associated with acute renal failure
Hipercalcemia masiva en la rabdomiólisis asociada a insuficiencia renal aguda
Eliana Olazoa, M. Dolores Sánchez-de la Nietaa, Francisco Riveraa, Sara Anayaa, Minerva Arambarria, Isabel Ferrerasa
a Servicio de Nefrología, Hospital General Universitario de Ciudad Real, Ciudad Real,
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        "titulo" => "Hipercalcemia masiva en la rabdomi&#243;lisis asociada a insuficiencia renal aguda"
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">To the Editor&#58;</span></p><p class="elsevierStylePara">Rhabdomyolysis &#40;RD&#41; is the process of cellular necrosis in striated muscle&#44; with the release of intracellular components into the blood stream&#46;<span class="elsevierStyleSup">1</span></p><p class="elsevierStylePara">Acute renal failure &#40;ARF&#41; appears in 15&#37;-50&#37; of cases of RD&#44; and can be associated with altered calcium metabolism with a biphasic pattern&#46; In the initial oliguric phase&#44; 60&#37; of patients with RD can develop hypocalcaemia&#46;<span class="elsevierStyleSup">2</span> In the recovery phase of ARF&#44; 20&#37;-30&#37; can develop hypercalcaemia&#46;<span class="elsevierStyleSup">3</span></p><p class="elsevierStylePara">The cases described in the literature of RD with hypercalcaemia equal to or greater than 15mg&#47;dl correspond to patients that initially suffered severe hypocalcaemia&#46;<span class="elsevierStyleSup">3-7</span></p><p class="elsevierStylePara">Here we present the case of RD secondary to intense exercise during grape harvest and associated with ARF&#44; in which&#44; following a mild initial bout of hypocalcaemia&#44; the patient developed severe hypercalcaemia at 15&#46;4mg&#47;dl&#46;</p><p class="elsevierStylePara">Our patient was a 21-year-old male with no relevant medical background&#46; Fifteen days prior to hospitalisation&#44; the patient started to suffer general malaise&#44; muscle pain&#44; vomiting&#44; swelling of the legs&#44; and dark urine followed by oligoanuria&#44; following intense exercise during grape harvest&#46; The patient&#8217;s primary physician started treatment with prokinetics&#44; muscle relaxants&#44; and antibiotics &#40;norfloxacin&#41;&#44; with no improvement&#46; A physical examination revealed skin and mucosae dehydration and bradypsychia&#46; The patient&#8217;s blood pressure was 150&#47;60mm Hg&#44; with a soft abdomen that produced slight pain upon deep palpation&#46; The muscles in the limbs were hardened&#44; and all other results were normal&#46;</p><p class="elsevierStylePara">A laboratory analysis revealed&#58; creatinine&#58; 16&#46;2mg&#47;dl&#59; urea&#58; 411mg&#47;dl&#59; maximum creatinine phosphokinase &#40;CPK&#41;&#58; 1000U&#47;l&#59; total protein&#58; 6&#46;3g&#47;dl&#59; albumin&#58; 3&#46;9g&#47;dl&#59; Na&#58; 134mEq&#47;l&#59; K&#58; 4mEq&#47;l&#59; Ca&#58; 7&#46;9mg&#47;dl&#59; P&#58; 9&#46;3mg&#47;dl&#46; A urine analysis revealed red blood cells &#43;&#43;&#43; and urinary sediment&#58; 7-8 red blood cells&#47;field &#40;Figure&#41;&#46; Viral serology &#40;for hepatitis B and C and human immunodeficiency virus&#41; was negative&#46; Chest x-ray and abdominal ultrasound results were normal&#46;</p><p class="elsevierStylePara">Given the patient&#8217;s severe state of nitrogen retention and symptoms indicative of uremic encephalopathy&#44; we administered two sessions of haemodialysis&#44; intense hydration therapy&#44; and urine alkalinisation&#46; This produced improvements in the clinical symptoms and laboratory results&#46; Despite this improvement&#44; the patient continued to suffer vomiting on the seventh day of treatment&#59; we performed more tests&#44; observing hypercalcaemia at 15&#46;4mg&#47;dl&#46; We administered intense hydration therapy&#44; diuretic treatment&#44; calcitonin&#44; and bisphosphonates&#46; Parathyroid hormone &#40;PTH&#41; levels were 7&#46;97pg&#47;ml&#44; and 25-dihydroxyvitamin D was at 22nmol&#47;l&#46; Upon discharge&#44; the patient&#8217;s creatinine level was 1&#46;8mg&#47;dl&#44; CPK was normal&#44; and serum Ca was at 8&#46;5mg&#47;dl&#46; In later follow-up sessions&#44; creatinine was at 0&#46;8mg&#47;dl and Ca and CPK values were with normal ranges &#40;Figure&#41;&#46;</p><p class="elsevierStylePara">Reviewing the medical literature&#44; we can observe more than 60 cases published since 1970 of hypercalcaemia associated with RD&#46;<span class="elsevierStyleSup">3-9</span> We can also note that the majority of cases described of hypercalcaemia &#62;15mg&#47;dl&#44; such as in our case&#44; initially present severe hypocalcaemia&#46;<span class="elsevierStyleSup">3-7</span> Our patient had mild hypocalcaemia at 7&#46;9mg&#47;dl during the oligoanuric phase&#44; and later developed hypercalcaemia at 15&#46;4mg&#47;dl&#46; In a similar manner&#44; Grobety et al&#46; described two cases of patients with mild hypocalcaemia during initial phases of RD&#44; at 7&#46;4mg&#47;dl and 7&#46;6mg&#47;dl&#44; who later developed severe hypercalcaemia at 15&#46;6mg&#47;dl and 15mg&#47;dl&#44; respectively&#46;<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara">Hypocalcaemia in RD tends to appear in the oliguric phase of ARF&#44; is normally temporary&#44; and can occasionally be severe and symptomatic&#46; Treatment with calcium salts and&#47;or vitamin D derivatives should be avoided&#44; since this could aggravate the state of hypercalcaemia produced in the recovery phase of RD&#46;<span class="elsevierStyleSup">9</span> Our patient did not require treatment&#44; since the hypocalcaemia was mild and asymptomatic&#46;</p><p class="elsevierStylePara">Hypercalcaemia in RD tends to occur in the phase of recovery of diuresis in the associated ARF&#59; this is primarily due to the release of calcium deposited in the muscles into the bloodstream&#44; along with mild hyperparathyroidism caused by renal failure&#46;<span class="elsevierStyleSup">4&#44;9</span> The majority of cases of hypercalcaemia are self-limiting&#44; and may only need observation and adequate hydration&#46;<span class="elsevierStyleSup">2</span> However&#44; certain patients require treatment with bisphosphonates&#44; calcitonin&#44; and loop diuretics&#44;<span class="elsevierStyleSup">2 </span>as in our case&#46;</p><p class="elsevierStylePara">Our patient did not require sequential PTH measurements during hospitalisation&#44; but during the phase of recovery from diuresis&#44; he did develop severe hypercalcaemia with suppressed PTH&#44; as in the majority of described cases&#46; However&#44; calcitriol levels were normal&#44; in contrast with the low levels described by other authors&#46;<span class="elsevierStyleSup">3&#44;4</span></p><p class="elsevierStylePara">To conclude&#44; the majority of cases of ARF associated with RD and severe hypercalcaemia initially present the form of severe hypocalcaemia&#44; and occasionally mild hypocalcaemia&#46; We described a case of severe hypercalcaemia in a patient with an initial mild decrease in calcium levels&#46; This suggests that severe hypercalcaemia following mild hypocalcaemia might be the result of approaching the case of RD when it was already substantially progressed&#44; or due to outside factors&#46; Our case may have been one of late RD&#44; although we cannot confirm this&#44; since we do not have laboratory analyses from before the patient was hospitalised&#46; However&#44; when presented with a patient with ARF and RD&#44; we must monitor calcium kinetics alterations&#44; even when serum calcium levels in the initial phase are normal or only slightly low&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara">The authors have no conflicts of interest to declare&#46;</p><p class="elsevierStylePara"><a href="grande&#47;11577&#95;16025&#95;35738&#95;en&#95;f111577&#46;jpg" class="elsevierStyleCrossRefs"><img src="11577_16025_35738_en_f111577.jpg" alt="Evolution of calcium&#44; phosphorous&#44; and creatinine levels during hospitalisation and after discharge"></img></a></p><p class="elsevierStylePara">Figure 1&#46; Evolution of calcium&#44; phosphorous&#44; and creatinine levels during hospitalisation and after discharge</p>"
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                  "referenciaCompleta" => "Cetinkaya R,\u{A0}Uyanik A,\u{A0}Keles M, Bilen Y. The rhabdomyolysis related acute renal failure and biphasic calcium metabolism. Pak J Med Sci 2009;25(1):152-4."
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Idiomas
Nefrología (English Edition)