Catheter-related relapsing peritonitis due to Kocuria varians in a patient undergoing Continuous Ambulatory Peritoneal Dialysis
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Hospital, Veroia, Greece, " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] 1 => array:3 [ "entidad" => "Nephrology Department, Veroia G. Hospital, Veroia, Greece, " "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "affb" ] ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Dear Editor,</span></p><p class="elsevierStylePara"><span class="elsevierStyleItalic">Kocuria varians</span> is a Gram positive non-pathogenic commensal of the mammalian skin that can be present also in soil and water. <span class="elsevierStyleItalic">Kocuria</span> spp. was previously classified in the genus Micrococcus<span class="elsevierStyleSup">1</span> and identification of the species by automated systems has been reported to be problematic.<span class="elsevierStyleSup">2</span> Published cases of infections caused by <span class="elsevierStyleItalic">Kocuria varians</span> in the English literature are rare and consider patients with serious underlying disease.<span class="elsevierStyleSup">3</span> We report here a case of relapsing peritonitis in a patient undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) that was resolved after catheter removal.</p><p class="elsevierStylePara">The patient, a 70-year-old man with chronic renal failure and class III heart failure was admitted to the hospital on 26 July 2010 with turbid peritoneal dialysate, non febrile, having mild abdominal pain and positive Rebound sign at the physical examination. Leucocyte cell count showed the presence of 1200 leucocytes/μl (neutrophil count of 90%) in the peritoneal dialysate but subsequent culture of the fluid resulted negative. Treatment started with vancomycin 15mg/kg/5 days i.p. and aztreonam 2gr/d i.p. for a total of 20 days. On 30 July 2010 cell count was 50 leucocytes/μl and the patient was discharged.</p><p class="elsevierStylePara">3 days later however, at the first control visit, the peritoneal dialysate was turbid anew, the patient presented the same clinical findings and cell count revealed the presence of 300 leucocytes/μl. A Gram positive, spherical microorganism that occurred in tetrads with circular, smooth, glistering and yellow colonies was recovered from the peritoneal dialysate. The microorganism was identified as <span class="elsevierStyleItalic">Kocuria varians</span> by the VITEK 2 system. The isolate was susceptible to gentamycin, erythromycin, clindamycin, tetracycline, glycopeptides and linezolid while it was resistant to levofloxacin by the disc diffusion method. Following laboratory report, the patient was treated with vancomycin alone (15mg/kg/5 days i.p. for a total of 20 days).</p><p class="elsevierStylePara">Turbidity of the peritoneal dialysate did not reappear until 27 August 2010 when the patient was admitted to the hospital with generalized abdominal pain, positive Rebound sign and cell count of 550 leucocytes/μl. <span class="elsevierStyleItalic">K. varians</span> was isolated for the second time and removal of the peritoneal catheter followed by insertion of a new one in a different position was considered. Culture of the removed catheter was positive for <span class="elsevierStyleItalic">K. varians</span>. Vancomycin i.p. was administered, subsequent cultures were negative and the patient remained in good clinical condition since then.</p><p class="elsevierStylePara">Infections related to <span class="elsevierStyleItalic">K. varians</span> are uncommon but this species may act as opportunistic pathogen in immunocompromised patients with underlying diseases. Furthermore, <span class="elsevierStyleItalic">K. varians</span> is a biofilm forming bacterium<span class="elsevierStyleSup">4</span> thus probably complicating the antimicrobial treatment of catheter related infections. Erroneous identification of coagulase-negative Staphylococci as <span class="elsevierStyleItalic">Kocuria </span>spp. is possible and can be excluded with certainty only with the application of genotypic assays such as 16S RNA.<span class="elsevierStyleSup">1</span> In the present case the Vitek 2 system using the new GP identification card<span class="elsevierStyleSup">5</span> reported a “very good identification” for all three isolations. This case report aims on emphasizing the importance of careful consideration of the laboratory and clinical procedures when rarely pathogenic microorganisms are isolated in the peritoneal dialysate of patients undergoing CAPD.</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> </span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors declare that there is no conflict of interest associated with this manuscript.</p>" "pdfFichero" => "P1-E541-S3640-A11471-EN.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Stackebrandt E, Koch C, Gvozdiak O, Schumann P. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend. Int J Syst Bacteriol 1995;45:682-92." "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Ben-Ami R, Navon-Venezia S, Schwartz D, Schlezinger Y, Mekuzas Y, Carmeli Y. Erroneous reporting of coagulase-negative Staphylococci as Kocuria spp. by the Vitek 2 system. J Clin Microbiol 2005;43:1448-50. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15750130" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Tsai CY, Su SH, Cheng YH, Chou YL, Tsai TH, Lieu AS. Kocuria varians infection associated with brain abscess: A case report. BMC Infect Dis 2010;10:102. <a href="http://www.ncbi.nlm.nih.gov/pubmed/20423506" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Midelet G, Kobilinsky A, Carpentier B. Construction and analysis of fractional multifactorial designs to study attachment strength and transfer of Listeria monocytogenes from pure or mixed biofilms after contact with a solid model food. Appl Environ Microbiol 2006;72:2313-21. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16597925" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Boudewijns M, Vandeven J, Verhaegen J, Ben-Ami R, Carmeli Y. Vitek 2 automated identification system and Kocuria kristinae. J Clin Microbiol 2005;43:5832. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16272536" target="_blank">[Pubmed]</a>" "contribucion" => array:1 [ 0 => null ] "host" => array:1 [ 0 => null ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/20132514/0000003200000004/v0_201502091610/X2013251412001454/v0_201502091610/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000004/v0_201502091610/X2013251412001454/v0_201502091610/en/P1-E541-S3640-A11471-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001454?idApp=UINPBA000064" ]
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| 2015 July | 48 | 0 | 48 |
| 2015 June | 38 | 0 | 38 |
| 2015 May | 28 | 0 | 28 |
| 2015 April | 5 | 0 | 5 |
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