Selective immunoglobulin A deficit in a haemodialysis patient
Déficit selectivo de inmunoglobulina A en paciente en hemodiálisis
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Its clinical spectrum is broad and ranges from nondescript symptoms (recurring ear, respiratory or gastrointestinal conditions) to severe invasive complications or even autoimmune disease (20%-30% of all cases). Another class of common manifestations in these patients are food allergies, asthma or post-transfusion allergies (10%-15% of the total).<span class="elsevierStyleSup">1,2</span></p><p class="elsevierStylePara">In this singular pathogenic context (which has a variable incidence of 1:100-1:1000 individuals), we present the case of a 62-year-old patient with a history of advanced chronic kidney disease, who initiated urgent haemodialysis in the intensive care unit due to fluid overload, along with a cardiac tamponade that required evacuative pericardiocentesis. The patient’s medical history included: high blood pressure, asymmetrical renal ultrasound (right kidney: 117mm vs left kidney: 96mm), atrial fibrillation, chronic degenerative vascular encephalopathy with long-term thalamic haematoma caused by anticoagulation with dicoumarin derivatives, monoclonal gammopathy with mild anaemia and thrombocytopenia, urticaria-angiooedema with sensitivity to anisakis and intolerance to NSAIDs, recurrent respiratory infections with chronic bronchial disease, negative coagulopathy screening study, and unconfirmed findings of a weakly positive lupus anticoagulant. As for his clinical condition, uraemic symptoms upon hospitalisation – from the first dialysis session and despite meeting the quality standards of the dialysis fluid (ultrapure water: <0.1CFU/ml, <0.03EU/ml endotoxin) – were accompanied by frequent episodes of hypersensitivity (HPS) type A in the form of hypotension and angioedema with poor response to prophylactic steroid therapy, changes in heparin prescription, dialyser change (polysulfone 1.8m<span class="elsevierStyleSup">2</span> sterilised with in line steam, polyarylethersulfone-polyamide 2.1m<span class="elsevierStyleSup">2</span> sterilised with gamma rays, polyacrylonitrile 2.15m<span class="elsevierStyleSup">2</span> sterilised with gamma rays, heparinised Hephran 1.65m<span class="elsevierStyleSup">2</span> sterilised with gamma rays, etc.) and even transition from on-line haemodiafiltration to high-flow haemodialysis. This simultaneously hindered giving appropriate renal replacement therapy, and constituted an obstacle to the recovery of the patient, which was delayed for several weeks.</p><p class="elsevierStylePara">The additional tests required for the evaluation of the overall process and HPS were:</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Pre-dialysis biochemistry:</span> glucose: 70mg/dl; urea: 159mg/dl; creatinine: 7.9mg/dl; calcium: 8mg/dl; rheumatoid factor: 11.9IU/ml; total protein: 6.5g/dl; proteinuria in 24-hour urine sample: 835mg/l; and Bence-Jones proteinuria: negative.</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Haemogram:</span> leukocytes: 10030/μl (polymorphonuclear: 84.8%; lymphocytes: 6.6%; monocytes: 5.4%; eosinophils: 2%; basophils: 0.1%); haemoglobin: 8.6mg/dl (average cell volume: 91.7); platelets: 261,000/μl; direct Coombs: negative.</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Immunity:</span> antinuclear antibodies and antineutrophil cytoplasmic antibody: negative; C3/C4: 123/33.9mg/dl, lupus anticoagulant: (-).</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Serology:</span> HbsAc-HbcAc: (+); hepatitis C virus: (-); human immunodeficiency virus: (-); negative syphilis.</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Tumour markers:</span> negative.</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Electrophoresis:</span> albumin: 52.1% (↓); gamma-globulins: 19.7% (↑); albumin / globulin: 1.09%, with no monoclonal component.</p><p class="elsevierStylePara">- <span class="elsevierStyleBold">Immunoglobulin: </span>IgG: 1412mg/dl; IgM: 121mg/dl; and IgA: 0mg/dl.</p><p class="elsevierStylePara">As to <span class="elsevierStyleBold">specific allergy tests,</span> there was a very high total IgE (394KU/L), with negative tests for chloramines, latex of the extracorporeal circuit, and ethylene oxide/formaldehyde used as sterilisers.</p><p class="elsevierStylePara">Finally, and due to the suspected link between the allergic/thrombogenic tendency of the patient, the selective IgA humoral immunodeficiency and HPS manifested during dialysis, it was decided to also request specialised assessment from the haematology department, which excluded any spinal or immunological process different from that observed. However, ambulatory analysis of lymphocyte subpopulations provided new results: total lymphocyte count: 1172/μl (0.9 to 5.2x10<span class="elsevierStyleSup">3</span>/µl); CD3-T: 889 cells/µl 75% (58%-87%); CD3-CD4+: 52% (32%-62%); CD3-CD8+: 19% (12%-45%); CD4/CD8 ratio: 2.7 (0.8 to 4.5); CD19-B: 92 cells/ml 7% (7%-23%); and CD16-NK: 15% (4%-27%).</p><p class="elsevierStylePara">Thus, having excluded other causes of combined or secondary immunodeficiency, the final diagnosis was established: selective IgA deficiency linked to an allergic substrate with a tendency towards lymphocytopenia, normal CD4/CD8 ratio, and relative decline in B lymphocytes. The clinical expression of the patient’s condition was not consistent with a reaction to latex, bio-incompatible membranes, or bradykinin release due to ethylene oxide.<span class="elsevierStyleSup">3-5 </span>In contrast, its relationship with the IgE-mediated HPS was obvious. For that reason, the most plausible pathophysiological hypothesis for the manifestation of these symptoms was: 1) IgA deficiency caused initial antigenic overstimulation of CD4 T-cells, responsible for the activation of C3-CD8 and CD19-B lymphocytes, and as a result, the activation of cellular and humoral immunity<span class="elsevierStyleSup">6</span>; 2) there was an abnormal maturation of B clones, responsible for the synthesis of IgA, hence the relative deficit of CD19-B in our patient; however, this was not the case of other immunoglobulins such as IgE, which promote immediate mast cell degranulation when coming into contact with the antigenic factor<span class="elsevierStyleSup">7,8</span>; and 3) there was a tendency to develop infections and autoimmune mechanisms in these patients, where the uncontrolled external antigenaemia by IgA dimers was capable of inducing a direct cytotoxic response or a response mediated by Ag-Ac complexes.<span class="elsevierStyleSup">6</span></p><p class="elsevierStylePara">In this area of immunopathology, the proposed treatment was directed primarily at inhibiting the reaction of the extracorporeal blood-circuit interface, for which clinical experiences in the literature on pH-metric modulation of intradialytic anaphylaxis were reviewed.<span class="elsevierStyleSup">9 </span>This was used to establish a screening protocol for patients with 1/6M-bicarbonate bloodlines (prior to connection during each session) resulting from the onset in an alkalising effect that resolved the episodes of angioedema and haemodynamic instability. Secondly, we also adopted other therapeutic and hygiene measures for the prevention of infectious complications in the patient, such as the creation of an arteriovenous fistula, which was preferable over the central venous catheter that was being used, or even the early administration of antibiotic therapy in the case of respiratory infection. However, we did not consider correcting the IgA deficiency with exogenous immunotherapy, as severe cases of HPS secondary to the formation of anti-IgA antibodies have been described.<span class="elsevierStyleSup">10</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara"> </p><p class="elsevierStylePara">The authors declare no conflict of interest related to the content of this article.</p>" "pdfFichero" => "P1-E541-S3640-A11416-EN.pdf" "tienePdf" => true ] "idiomaDefecto" => "en" "url" => "/20132514/0000003200000004/v0_201502091610/X2013251412001438/v0_201502091610/en/main.assets" "Apartado" => array:4 [ "identificador" => "35437" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor - Brief Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000004/v0_201502091610/X2013251412001438/v0_201502091610/en/P1-E541-S3640-A11416-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001438?idApp=UINPBA000064" ]
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