Statistics

 array:21 [
  "pii" => "X2013251412001133"
  "issn" => "20132514"
  "doi" => "10.3265/Nefrologia.pre2011.Dec.11308"
  "estado" => "S300"
  "fechaPublicacion" => "2012-05-01"
  "documento" => "article"
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Nefrologia (English Version). 2012;32:403-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 6390
    "formatos" => array:3 [
      "EPUB" => 333
      "HTML" => 5369
      "PDF" => 688
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:17 [
      "pii" => "X0211699512001136"
      "issn" => "02116995"
      "doi" => "10.3265/Nefrologia.pre2011.Dec.11308"
      "estado" => "S300"
      "fechaPublicacion" => "2012-05-01"
      "documento" => "article"
      "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
      "subdocumento" => "fla"
      "cita" => "Nefrologia. 2012;32:403-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 8771
        "formatos" => array:3 [
          "EPUB" => 318
          "HTML" => 7569
          "PDF" => 884
        ]
      ]
      "es" => array:9 [
        "idiomaDefecto" => true
        "titulo" => "Acidosis metabólica inducida por topiramato: a propósito de un caso."
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "403"
            "paginaFinal" => "404"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Topiramate-induced metabolic acidosis: a case study"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Lucía Fernández-de Orueta, Javier Esteban-Fernández, Harald F.J. Aichner, Ángel Casillas-Villamor, Sergio Rodríguez-Álvarez"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "Lucía"
                "apellidos" => "Fernández-de Orueta"
              ]
              1 => array:2 [
                "nombre" => "Javier"
                "apellidos" => "Esteban-Fernández"
              ]
              2 => array:2 [
                "nombre" => "Harald F.J."
                "apellidos" => "Aichner"
              ]
              3 => array:2 [
                "nombre" => "Ángel"
                "apellidos" => "Casillas-Villamor"
              ]
              4 => array:2 [
                "nombre" => "Sergio"
                "apellidos" => "Rodríguez-Álvarez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "X2013251412001133"
          "doi" => "10.3265/Nefrologia.pre2011.Dec.11308"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001133?idApp=UINPBA000064"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001136?idApp=UINPBA000064"
      "url" => "/02116995/0000003200000003/v0_201502091350/X0211699512001136/v0_201502091351/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:17 [
    "pii" => "X2013251412001125"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Jan.11347"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:404-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 11927
      "formatos" => array:3 [
        "EPUB" => 314
        "HTML" => 11010
        "PDF" => 603
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Giant true aneurysm of the radial artery following ligation of an arteriovenous fistula for haemodialysis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "404"
          "paginaFinal" => "406"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Aneurisma verdadero gigante de la arteria radial tras ligadura de fístula arteriovenosa para hemodiálisis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Fig. 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11347_16025_30607_en_f1_811347.jpg"
              "Alto" => 472
              "Ancho" => 1386
              "Tamanyo" => 291973
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Physical examination"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => " Servicio de Angiología y Cirugía Vascular del Hospital Universitario Miguel Servet,  en nombre del Grupo Servicio de Angiología y Cirugía Vascular, Cristina Feijoo-Cano en nombre del grupo del Servicio de Angiología y Cirugía Vascular del Hospital Universitario Miguel Servet"
          "autores" => array:4 [
            0 => array:1 [
              "apellidos" => "Servicio de Angiología y Cirugía Vascular del Hospital Universitario Miguel Servet"
            ]
            1 => array:1 [
              "apellidos" => "en nombre del Grupo Servicio de Angiología y Cirugía Vascular"
            ]
            2 => array:2 [
              "nombre" => "Cristina"
              "apellidos" => "Feijoo-Cano en nombre del grupo del Servicio de Angiología y Cirugía Vascular del Hospital Universitario Miguel Servet"
            ]
            3 => array:2 [
              "nombre" => "Cristina"
              "apellidos" => "Feijoo-Cano"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512001128"
        "doi" => "10.3265/Nefrologia.pre2012.Jan.11347"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001128?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001125?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001125/v0_201502091614/en/main.assets"
  ]
  "itemAnterior" => array:17 [
    "pii" => "X2013251412001141"
    "issn" => "20132514"
    "doi" => "10.3265/Nefrologia.pre2012.Mar.11397"
    "estado" => "S300"
    "fechaPublicacion" => "2012-05-01"
    "documento" => "article"
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Nefrologia (English Version). 2012;32:402-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4281
      "formatos" => array:3 [
        "EPUB" => 287
        "HTML" => 3291
        "PDF" => 703
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Monitoring haemodialysis in the Cabueñes Hospital"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "402"
          "paginaFinal" => "403"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Monitorización en hemodiálisis en el Hospital de Cabueñes"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig1"
          "etiqueta" => "Tab.  1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "copyright" => "Elsevier España"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "11397_16025_30585_en_t1_611397.jpg"
              "Alto" => 384
              "Ancho" => 1440
              "Tamanyo" => 182074
            ]
          ]
          "descripcion" => array:1 [
            "en" => "Prevalence during 2011"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Suárez-Laurés, Luis Quiñones-Ortiz, Miguel de la Torre-Fernández, Adolfo Torres-Lacalle, Montse de Pablos-Pablo, Susana Puccini, Ramón Forascepi-Roza"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Suárez-Laurés"
            ]
            1 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Quiñones-Ortiz"
            ]
            2 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "de la Torre-Fernández"
            ]
            3 => array:2 [
              "nombre" => "Adolfo"
              "apellidos" => "Torres-Lacalle"
            ]
            4 => array:2 [
              "nombre" => "Montse"
              "apellidos" => "de Pablos-Pablo"
            ]
            5 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Puccini"
            ]
            6 => array:2 [
              "nombre" => "Ramón"
              "apellidos" => "Forascepi-Roza"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "X0211699512001144"
        "doi" => "10.3265/Nefrologia.pre2012.Mar.11397"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X0211699512001144?idApp=UINPBA000064"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001141?idApp=UINPBA000064"
    "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001141/v0_201502091614/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Topiramate-induced metabolic acidosis: a case study"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "403"
        "paginaFinal" => "404"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Lucía Fernández-de Orueta, Javier Esteban-Fernández, Harald F.J. Aichner, Ángel Casillas-Villamor, Sergio Rodríguez-Álvarez"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Lucía"
            "apellidos" => "Fernández-de Orueta"
            "email" => array:1 [
              0 => "luciafdezdeorueta@gmail.com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Javier"
            "apellidos" => "Esteban-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Harald F&#46;J&#46;"
            "apellidos" => "Aichner"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "&#193;ngel"
            "apellidos" => "Casillas-Villamor"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Sergio"
            "apellidos" => "Rodr&#237;guez-&#193;lvarez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Interna, Hospital Universitario de Getafe, Getafe, Madrid,  "
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Acidosis metab&#243;lica inducida por topiramato&#58; a prop&#243;sito de un caso&#46;"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara">We present the case of a 75 year-old male with hypertension and chronic obstructive pulmonary disease who was diagnosed with chronic delusional disorder and mixed personality disorder&#44; along with partial epilepsy due to a left parietal haematoma from several years prior&#46; The patient was under treatment with topiramate&#44; levetiracetam&#44; quetiapine&#44; sertraline&#44; clobazam&#44; and bronchodilators&#46; He sought treatment for a respiratory infection and functional deterioration consisting of apathy&#44; drowsiness&#44; and periods of aggressive behaviour&#46; A physical examination revealed that the patient had no fever&#44; although he did suffer from disorientation and slurred speech&#44; and would drift off to sleep&#44; but with no apparent focal loss of motor function&#46; The patient also had shallow tachypnoea&#44; widespread rhonchi&#44; and crackles in the left base&#44; with radiological images indicative of superinfection of the abnormally widened bronchial tubes&#46; We performed a laboratory analysis&#44; revealing mildly elevated chlorine &#40;114mEq&#47;l&#41;&#44; with normal renal function and all other ion parameters &#40;sodium&#58; 138mEq&#47;l&#59; potassium&#58; 4&#46;2mEq&#47;l&#41;&#44; and baseline arterial gasses compatible with a diagnosis of metabolic acidosis &#40;pH&#58; 7&#46;24&#59; pCO<span class="elsevierStyleInf">2</span>&#58; 33mm Hg&#59; pO<span class="elsevierStyleInf">2</span>&#58; 67mm Hg&#59; bicarbonate&#58; 17mmol&#47;l&#59; base excess &#91;BE&#93;&#58; -9&#46;1mmol&#47;l&#41;&#46; The anion GAP value &#40;difference between serum sodium and the sum of chlorine and bicarbonate&#41; was 7mEq&#47;l&#46; The patient received treatment with systemic steroids and quinolones&#44; with rapid clinical improvement until reaching a normal baseline levels&#46; However&#44; later controls revealed persistent hyperchloremic metabolic acidosis&#59; after ruling out other possibilities&#44; we attributed this fact to the chronic treatment with topiramate&#44; which was suspended and replaced with phenytoin&#44; which completely resolved the altered laboratory values by the time the patient was discharged&#46;</p><p class="elsevierStylePara">Topiramate is a sulphamate with anti-epileptic effects&#44; and is indicated in preventative treatment of migrane&#44;<span class="elsevierStyleSup">1&#44;2</span> the treatment of neuropathic pain<span class="elsevierStyleSup">3</span>&#44; bipolar disorder&#44;<span class="elsevierStyleSup">3</span> tobacco dependence&#44; and bulimia nervosa&#44;<span class="elsevierStyleSup">4</span> among other pathologies&#46; Its most common secondary side effects<span class="elsevierStyleSup">2&#44;5</span> are asthenia&#44; dizziness&#44; drowsiness&#44; emotional lability&#44; and weight loss&#46; The development of urolithiasis and hyperchloremic metabolic acidosis with a normal anion GAP is much less common&#44; but has been reported&#46; Topiramate has a molecular structure very similar to acetazolamide<span class="elsevierStyleSup">2&#44;6</span> and inhibits the carbonic anhydrase enzyme&#44;<span class="elsevierStyleSup">3&#44;6</span> especially the type II isoenzyme that predominates in human kidneys&#46;<span class="elsevierStyleSup">1&#44;2&#44;6</span> This can lead to mixed renal tubular acidosis<span class="elsevierStyleSup">1</span> &#40;type 3&#41; as a result of ultrafiltration and reabsorption of bicarbonate in both proximal and distal tubules&#44;<span class="elsevierStyleSup">4</span> thus altering urine acidification and provoking a decrease in serum bicarbonate and CO<span class="elsevierStyleInf">2</span> concentrations&#44;<span class="elsevierStyleSup">4</span> which is usually mild and asymptomatic&#44;<span class="elsevierStyleSup">7&#44;8</span> although can produce hyperventilation&#44;<span class="elsevierStyleSup">3&#44;4</span> neurological symptoms&#44;<span class="elsevierStyleSup">3</span> nephrolithiasis&#44; osteoporosis&#44; and osteomalacia in the long term&#46; The circumstances that predispose patients to developing this complication are not well established&#44; but patients are more likely to develop it if they have other conditions that cause acidosis&#44; such as infections&#44; diabetic ketoacidosis&#44; chronic renal failure&#44; or surgery&#46;<span class="elsevierStyleSup">4&#44;5</span> Certain genetic polymorphisms in the involved carbonic anhydrase isoenzymes may explain a greater or lesser susceptibility of certain patients to develop this complication&#46;<span class="elsevierStyleSup">3&#44;9</span> Some authors have suggested the possibility of monitoring bicarbonate<span class="elsevierStyleSup">1&#44;6</span> or CO<span class="elsevierStyleInf">2</span><span class="elsevierStyleSup">3&#44;5</span> levels to predict these cases&#44; although this is not a completely validated method&#46; The development of metabolic acidosis during chronic treatment with topiramate is a reversible condition&#44; regardless of the dosage<span class="elsevierStyleSup">3&#44;9</span> and duration of treatment&#46;9 The only treatment is to suspend the use of the drug10 &#40;there is no antidote&#41; and replace it with a substitute&#46; When the withdrawal of the drug is not possible&#44; and the patient maintains acceptable levels of pH and serum bicarbonate&#44; with no symptoms&#44; indefinite treatment with oral alkaline supplements can be administered &#40;sodium citrate or citric acid1&#41;&#46;</p><p class="elsevierStylePara">&#160;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest</span></p><p class="elsevierStylePara">The authors affirm that they have no conflicts of interest related to the content of this article&#46;</p>"
    "pdfFichero" => "P1-E536-S3514-A11308-EN.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "1.\u{A0}Mirza N, Marson AG, Pirmohamed M. Effect of topiramate on acid-base balance: extent, mechanism and effects. Br J Clin Pharmacol 2009;68:655-61. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19916989" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Sacré A, Jouret F, Manicourt D, Devuyst O. Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. Nephrol Dial Transplant 2006;21:2995-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16735391" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Burmeister JE, Pereira RR, Hartke EM, Kreuz M. Topiramate and severe metabolic acidosis: case report. Arq Neuropsiquiatr 2005;63:532-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16059613" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "García Gil D, Pérez V, Asencio C, García-Torrejón J. Acute topiramete toxicity to suicidal attempt. Med Clin (Barc) 2009;133:766-7."
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "5.\u{A0}Montenegro MA, Guerreiro MM, Scotoni AE, Guerreiro CA. Predisposition to metabolic acidosis induced by topiramate. Arq Neuropsiquiatr 2000;58:1021-4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/11105067" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Sujan S, Torres de Rueda A, Montero L, Toledo R, Ros S, Martín Reyes G. Topiramate-induced renal tubular acidosis. A case report. Nefrologia. 2008;28(6):656-7. "
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Garris SS, Oles KS. Impact of topiramate on serum bicarbonate concentrations in adults. Ann Pharmacother 2005;39:424-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15701764" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Groeper K, McCann ME. Topiramate and metabolic acidosis: a case series and review of the literature. Paediatr Anaesth 2005;15:167-70. <a href="http://www.ncbi.nlm.nih.gov/pubmed/15675937" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "9.\u{A0}Mirza NS, Alfirevic A, Jorgensen A, Marson AG, Pirmohamed M. Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. Pharmacogenet Genomics 2011;21:297-302. <a href="http://www.ncbi.nlm.nih.gov/pubmed/21278619" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:3 [
                  "referenciaCompleta" => "Shiber JR. Severe non-anion gap metabolic acidosis induced by topiramate: a case report. J Emerg Med 2010;38:494-6. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19232874" target="_blank">[Pubmed]</a>"
                  "contribucion" => array:1 [
                    0 => null
                  ]
                  "host" => array:1 [
                    0 => null
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/20132514/0000003200000003/v0_201502091613/X2013251412001133/v0_201502091614/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "35437"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor - Brief Case Reports"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/20132514/0000003200000003/v0_201502091613/X2013251412001133/v0_201502091614/en/P1-E536-S3514-A11308-EN.pdf?idApp=UINPBA000064&text.app=https://revistanefrologia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X2013251412001133?idApp=UINPBA000064"
]